BMP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Differential expression of this gene may be associated with progression of breast and prostate cancer. Mutations in this gene may be associated with iron overload in human patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endothelium development (GO:0003158)7.81770162
2angiogenesis involved in wound healing (GO:0060055)5.51981309
3thrombin receptor signaling pathway (GO:0070493)5.15133590
4regulation of acrosome reaction (GO:0060046)4.89308183
5cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.67362444
6negative regulation of adherens junction organization (GO:1903392)4.62752842
7negative regulation of focal adhesion assembly (GO:0051895)4.62752842
8negative regulation of cell junction assembly (GO:1901889)4.62752842
9cartilage condensation (GO:0001502)4.49901207
10cell aggregation (GO:0098743)4.49901207
11negative regulation of homotypic cell-cell adhesion (GO:0034111)4.41855567
12protein kinase C signaling (GO:0070528)4.41698290
13keratan sulfate catabolic process (GO:0042340)4.41456245
14regulation of DNA methylation (GO:0044030)4.39003655
15negative regulation of platelet activation (GO:0010544)4.34784540
16notochord development (GO:0030903)4.23641391
17multicellular organism reproduction (GO:0032504)4.14132304
18regulation of platelet activation (GO:0010543)4.02968518
19positive regulation of receptor recycling (GO:0001921)3.95084629
20oocyte development (GO:0048599)3.94713371
21* positive regulation of endothelial cell differentiation (GO:0045603)3.94447409
22neutrophil activation involved in immune response (GO:0002283)3.91934172
23wound healing, spreading of epidermal cells (GO:0035313)3.89498753
24regulation of integrin activation (GO:0033623)3.82337474
25chondrocyte development (GO:0002063)3.77992699
26negative regulation of blood vessel endothelial cell migration (GO:0043537)3.70462408
27regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.65761920
28regulation of lipoprotein metabolic process (GO:0050746)3.65592784
29blood coagulation, intrinsic pathway (GO:0007597)3.64628740
30regulation of histone H3-K9 methylation (GO:0051570)3.59441163
31regulation of phospholipid biosynthetic process (GO:0071071)3.59234793
32citrulline biosynthetic process (GO:0019240)3.57275797
33platelet degranulation (GO:0002576)3.52139241
34adenosine receptor signaling pathway (GO:0001973)3.49652672
35regulation of platelet aggregation (GO:0090330)3.44312948
36positive regulation of endothelial cell apoptotic process (GO:2000353)3.43198591
37surfactant homeostasis (GO:0043129)3.42705920
38positive regulation of blood coagulation (GO:0030194)3.39651513
39positive regulation of hemostasis (GO:1900048)3.39651513
40negative regulation of histone methylation (GO:0031061)3.38727291
41positive regulation of humoral immune response (GO:0002922)3.32561889
42endothelial cell morphogenesis (GO:0001886)3.31059196
43regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.26523968
44positive regulation of coagulation (GO:0050820)3.24263190
45positive regulation of extracellular matrix organization (GO:1903055)3.23943635
46negative regulation of reproductive process (GO:2000242)3.23091156
47substrate-dependent cell migration (GO:0006929)3.22532731
48positive regulation of blood vessel endothelial cell migration (GO:0043536)3.22333435
49negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.20435093
50collagen fibril organization (GO:0030199)3.19152385
51regulation of blood vessel endothelial cell migration (GO:0043535)3.12600584
52lung epithelium development (GO:0060428)3.11985779
53negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.11937260
54regulation of extracellular matrix disassembly (GO:0010715)3.11035617
55platelet aggregation (GO:0070527)3.08202004
56positive regulation of endothelial cell migration (GO:0010595)3.04354707
57cardiac myofibril assembly (GO:0055003)3.03921879
58regulation of early endosome to late endosome transport (GO:2000641)3.03765988
59endocardial cushion morphogenesis (GO:0003203)3.02854625
60regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.99617993
61negative regulation of vascular permeability (GO:0043116)2.99414920
62mesodermal cell differentiation (GO:0048333)2.91960680
63urate metabolic process (GO:0046415)2.90683246
64sprouting angiogenesis (GO:0002040)2.90623074
65platelet activation (GO:0030168)2.89848707
66neuron remodeling (GO:0016322)2.89615582
67branching involved in salivary gland morphogenesis (GO:0060445)2.88956190
68growth hormone receptor signaling pathway (GO:0060396)2.88437685
69positive regulation of fibroblast migration (GO:0010763)2.88401061
70negative regulation of cell-matrix adhesion (GO:0001953)2.86552286
71phagocytosis, engulfment (GO:0006911)2.84187505
72lysine catabolic process (GO:0006554)2.83885010
73lysine metabolic process (GO:0006553)2.83885010
74positive regulation of isotype switching (GO:0045830)2.83253124
75wound healing, spreading of cells (GO:0044319)2.82970758
76peptide catabolic process (GO:0043171)2.82863624
77hyaluronan catabolic process (GO:0030214)2.82457965
78pathway-restricted SMAD protein phosphorylation (GO:0060389)2.81276613
79* replacement ossification (GO:0036075)2.80943306
80* endochondral ossification (GO:0001958)2.80943306
81viral entry into host cell (GO:0046718)2.80316301
82negative regulation of stress fiber assembly (GO:0051497)2.79418883
83negative regulation of smooth muscle cell differentiation (GO:0051151)2.78936134
84regulation of cardioblast differentiation (GO:0051890)2.77961554
85reproduction (GO:0000003)2.77912795
86lipoxygenase pathway (GO:0019372)2.77105142
87meiotic cell cycle (GO:0051321)2.75844190
88positive regulation of urine volume (GO:0035810)2.75610824
89lymph vessel development (GO:0001945)2.72988901
90blood vessel maturation (GO:0001955)2.72786900
91negative regulation of potassium ion transmembrane transport (GO:1901380)2.72096462
92chemical homeostasis within a tissue (GO:0048875)2.72010373
93vascular endothelial growth factor signaling pathway (GO:0038084)2.71912198
94positive regulation of odontogenesis (GO:0042482)2.70244512
95patterning of blood vessels (GO:0001569)2.69547777
96regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.69215596
97* regulation of endothelial cell differentiation (GO:0045601)2.67897846
98hypotonic response (GO:0006971)2.66708798
99renal filtration (GO:0097205)2.65899091
100regulation of female gonad development (GO:2000194)2.63738484
101regulation of macrophage chemotaxis (GO:0010758)2.62513212
102regulation of integrin-mediated signaling pathway (GO:2001044)2.61628290
103collagen metabolic process (GO:0032963)2.61612778
104morphogenesis of an endothelium (GO:0003159)2.60839708
105endothelial tube morphogenesis (GO:0061154)2.60839708
106vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.60832423
107positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.60779069
108collagen catabolic process (GO:0030574)2.60373559
109keratan sulfate biosynthetic process (GO:0018146)2.59955205
110interleukin-6-mediated signaling pathway (GO:0070102)2.59898244
111glomerular filtration (GO:0003094)2.59710776
112lymphangiogenesis (GO:0001946)2.59599896
113regulation of endothelial cell migration (GO:0010594)2.58135054
114regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.57696046
115regulation of hippo signaling (GO:0035330)2.57268054
116basement membrane organization (GO:0071711)2.56691752
117multicellular organismal macromolecule metabolic process (GO:0044259)2.56042851
118positive regulation of fatty acid oxidation (GO:0046321)2.55636324
119positive regulation of wound healing (GO:0090303)2.55483656
120amino-acid betaine transport (GO:0015838)2.55101638
121carnitine transport (GO:0015879)2.55101638
122positive regulation of systemic arterial blood pressure (GO:0003084)2.54283298
123myoblast migration (GO:0051451)2.53213701
124heart trabecula formation (GO:0060347)2.53100934
125mesenchyme morphogenesis (GO:0072132)2.52600091
126SMAD protein complex assembly (GO:0007183)2.52285680
127regulation of fibroblast migration (GO:0010762)2.52063296
128regulation of blood coagulation (GO:0030193)2.51354465
129regulation of hemostasis (GO:1900046)2.51354465
130retina vasculature morphogenesis in camera-type eye (GO:0061299)2.50870774
131leukocyte migration involved in inflammatory response (GO:0002523)2.50352298
132substrate adhesion-dependent cell spreading (GO:0034446)2.50151529
133female gamete generation (GO:0007292)2.50132510
134drug catabolic process (GO:0042737)2.50079940
135hippo signaling (GO:0035329)2.49755509
136regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.49748372
137multicellular organismal metabolic process (GO:0044236)2.49634089
138positive regulation of mast cell activation (GO:0033005)2.49341625
139* positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.48580824
140regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.48209101
141negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.47917591
142negative regulation of norepinephrine secretion (GO:0010700)2.47822842
143cell volume homeostasis (GO:0006884)2.47331084
144multicellular organismal catabolic process (GO:0044243)2.47074021
145piRNA metabolic process (GO:0034587)2.46580946
146limb bud formation (GO:0060174)2.46475537
147phosphate ion transport (GO:0006817)2.46145719
148positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)2.45837249
149regulation of extracellular matrix organization (GO:1903053)2.45688170
150regulation of cell-substrate junction assembly (GO:0090109)2.44343575
151regulation of focal adhesion assembly (GO:0051893)2.44343575
152fibroblast migration (GO:0010761)2.43427422
153regulation of homotypic cell-cell adhesion (GO:0034110)2.42341930
154cellular response to growth hormone stimulus (GO:0071378)2.41959864
155fatty acid transmembrane transport (GO:1902001)2.41681144
156carnitine shuttle (GO:0006853)2.41448808
157myofibril assembly (GO:0030239)2.41246490
158negative regulation of fatty acid transport (GO:2000192)2.40937011
159glomerular epithelial cell development (GO:0072310)2.40204754
160regulation of vasculogenesis (GO:2001212)2.40173892
161type B pancreatic cell proliferation (GO:0044342)2.39216464
162protein targeting to plasma membrane (GO:0072661)2.38655795
163negative regulation of catenin import into nucleus (GO:0035414)2.38588975
164lung vasculature development (GO:0060426)2.35381924
165phosphate ion transmembrane transport (GO:0035435)2.35203329
166exogenous drug catabolic process (GO:0042738)2.33963004
167regulation of oxidative stress-induced neuron death (GO:1903203)2.33904320
168artery development (GO:0060840)2.33640099
169positive regulation of p38MAPK cascade (GO:1900745)2.33453247
170hyperosmotic salinity response (GO:0042538)2.33187952
171* cartilage development (GO:0051216)2.32936873
172regulation of sequestering of triglyceride (GO:0010889)2.31473978
173quaternary ammonium group transport (GO:0015697)2.31393492
174sarcomere organization (GO:0045214)2.31380663
175carnitine transmembrane transport (GO:1902603)2.30717295
176response to mercury ion (GO:0046689)2.30089173
177positive regulation of focal adhesion assembly (GO:0051894)2.29999052
178positive regulation of cell junction assembly (GO:1901890)2.29999052
179glomerular basement membrane development (GO:0032836)2.29320573
180cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.29115702
181protein localization to endosome (GO:0036010)2.28937706
182cellular response to osmotic stress (GO:0071470)2.26812636
183chondrocyte differentiation (GO:0002062)2.26235806
184atrioventricular valve morphogenesis (GO:0003181)2.25811460
185regulation of transforming growth factor beta2 production (GO:0032909)2.25575872
186extracellular matrix disassembly (GO:0022617)2.25495604
187cGMP-mediated signaling (GO:0019934)2.25230074
188plasma membrane repair (GO:0001778)2.25187580
189regulation of alkaline phosphatase activity (GO:0010692)2.24934674

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.55089814
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.42269591
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.89716909
4SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.19428115
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.85894755
6SCL_19346495_ChIP-Seq_HPC-7_Human2.85068861
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.64885281
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.55626284
9CLOCK_20551151_ChIP-Seq_293T_Human2.54906828
10MYB_21317192_ChIP-Seq_ERMYB_Mouse2.54300437
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.44056926
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.40285634
13EP300_21415370_ChIP-Seq_HL-1_Mouse2.38741530
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.29048319
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.28897361
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.24532730
17GATA1_19941826_ChIP-Seq_K562_Human2.23675335
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.16857386
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.16062684
20GATA1_19941827_ChIP-Seq_MEL_Mouse2.06344246
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.97850727
22ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.95168292
23TBX20_22080862_ChIP-Seq_HEART_Mouse1.92730934
24TBX20_22328084_ChIP-Seq_HEART_Mouse1.92730934
25SPI1_23127762_ChIP-Seq_K562_Human1.90214956
26TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.83166964
27GATA1_19941827_ChIP-Seq_MEL86_Mouse1.82579042
28GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.81745829
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.81482163
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.80117556
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79476675
32GATA2_19941826_ChIP-Seq_K562_Human1.77020175
33ZNF217_24962896_ChIP-Seq_MCF-7_Human1.76444479
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.74691897
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.73897976
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.73699152
37LXR_22158963_ChIP-Seq_LIVER_Mouse1.71965274
38IRF8_21731497_ChIP-ChIP_J774_Mouse1.70520611
39RXR_22158963_ChIP-Seq_LIVER_Mouse1.69993054
40ELK4_26923725_Chip-Seq_MESODERM_Mouse1.69722247
41IRF8_27001747_Chip-Seq_BMDM_Mouse1.68196685
42TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.67096363
43ESR1_20079471_ChIP-ChIP_T-47D_Human1.64196493
44* CJUN_26792858_Chip-Seq_BT549_Human1.64135736
45* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.63131206
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.60137964
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.59597309
48ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.59035086
49AR_21572438_ChIP-Seq_LNCaP_Human1.58566249
50GATA1_22383799_ChIP-Seq_G1ME_Mouse1.56873866
51PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.52573988
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.51494157
53GATA1_22025678_ChIP-Seq_K562_Human1.49442719
54GATA2_21666600_ChIP-Seq_HMVEC_Human1.49121609
55KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.49100965
56KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.49100965
57KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.49100965
58PPAR_26484153_Chip-Seq_NCI-H1993_Human1.48963581
59BRD4_27068464_Chip-Seq_AML-cells_Mouse1.47453478
60FOXO3_23340844_ChIP-Seq_DLD1_Human1.46716600
61RUNX_20019798_ChIP-Seq_JUKART_Human1.44950923
62EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.44877829
63* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.42756091
64* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.42756091
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42475853
66TP63_17297297_ChIP-ChIP_HaCaT_Human1.39978137
67KDM2B_26808549_Chip-Seq_K562_Human1.36995411
68RXR_22108803_ChIP-Seq_LS180_Human1.36341827
69ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.35103513
70RUNX1_22412390_ChIP-Seq_EML_Mouse1.34746781
71HIF1A_21447827_ChIP-Seq_MCF-7_Human1.34693282
72WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32282560
73TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32085686
74TCF7_22412390_ChIP-Seq_EML_Mouse1.32085379
75ZNF263_19887448_ChIP-Seq_K562_Human1.30616898
76MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30024404
77CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.29562379
78SALL4_18804426_ChIP-ChIP_XEN_Mouse1.29163901
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28263075
80* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.24615990
81PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24499139
82LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23415069
83NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.23015552
84TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.22993790
85FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.22501689
86FOXA2_19822575_ChIP-Seq_HepG2_Human1.22412490
87RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21890765
88* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21237251
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.20531401
90PPARA_22158963_ChIP-Seq_LIVER_Mouse1.20111839
91SOX9_24532713_ChIP-Seq_HFSC_Mouse1.20037915
92TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.19895541
93GF1_26923725_Chip-Seq_HPCs_Mouse1.16512346
94KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16322182
95RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14913620
96KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14320768
97P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13664088
98ISL1_27105846_Chip-Seq_CPCs_Mouse1.13639086
99PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.13280756
100* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12557180
101CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11859728
102RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.10889309
103WT1_19549856_ChIP-ChIP_CCG9911_Human1.10885924
104ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08766273
105* EED_16625203_ChIP-ChIP_MESCs_Mouse1.07702735
106SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.07071077
107SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.07071077
108PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07017227
109* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.05660438
110AHR_22903824_ChIP-Seq_MCF-7_Human1.05608529
111JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05145664
112FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05138394
113SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04609415
114SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.04522020
115SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02738369
116STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02303114
117VDR_24763502_ChIP-Seq_THP-1_Human1.01862585
118NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.01771270
119* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.00594527
120RUNX1_27514584_Chip-Seq_MCF-7_Human1.00094118
121NCOR1_26117541_ChIP-Seq_K562_Human0.99363326
122SALL1_21062744_ChIP-ChIP_HESCs_Human0.98484576
123SMAD3_21741376_ChIP-Seq_HESCs_Human0.98074504
124PIAS1_25552417_ChIP-Seq_VCAP_Human0.97221357
125GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96649120
126* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.96608326
127ARNT_22903824_ChIP-Seq_MCF-7_Human0.96455488
128* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.96128342
129* RNF2_27304074_Chip-Seq_ESCs_Mouse0.95304617
130KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.94927848
131* SMAD4_21741376_ChIP-Seq_HESCs_Human0.94468524
132TP63_23658742_ChIP-Seq_EP156T_Human0.94105640
133TCF4_18268006_ChIP-ChIP_LS174T_Human0.93446201
134* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.93076207
135SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.92631893
136NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92288715
137* KDM2B_26808549_Chip-Seq_JURKAT_Human0.92112522
138AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91738924
139* JARID2_20064375_ChIP-Seq_MESCs_Mouse0.91538396
140BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91493611
141RACK7_27058665_Chip-Seq_MCF-7_Human0.91411781
142LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91397609
143NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91109316
144SOX2_20726797_ChIP-Seq_SW620_Human0.91012375
145FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.90931141
146* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.90448183
147HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.88524905
148* EZH2_27304074_Chip-Seq_ESCs_Mouse0.88380248
149JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88268895
150BRD4_25478319_ChIP-Seq_HGPS_Human0.87939190
151GATA3_24758297_ChIP-Seq_MCF-7_Human0.87504102
152FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86915160
153CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.86880947
154SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.86375989
155* ELK3_25401928_ChIP-Seq_HUVEC_Human0.84850874
156STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.84557643
157UBF1/2_26484160_Chip-Seq_HMECs_Human0.84053995
158SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.79408444
159VDR_24787735_ChIP-Seq_THP-1_Human0.77218973
160VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.76233636

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.76657761
2MP0005464_abnormal_platelet_physiology4.46160619
3MP0000465_gastrointestinal_hemorrhage4.14555786
4MP0003303_peritoneal_inflammation3.87583621
5MP0008004_abnormal_stomach_pH3.73921548
6MP0003724_increased_susceptibility_to3.43199269
7MP0003718_maternal_effect3.39087730
8MP0010368_abnormal_lymphatic_system3.30368486
9MP0000751_myopathy3.00585755
10MP0003828_pulmonary_edema2.84003182
11MP0004272_abnormal_basement_membrane2.82592074
12MP0004084_abnormal_cardiac_muscle2.79202573
13MP0001958_emphysema2.69133434
14MP0005503_abnormal_tendon_morphology2.50483925
15MP0003705_abnormal_hypodermis_morpholog2.39235199
16MP0002282_abnormal_trachea_morphology2.26469767
17MP0004510_myositis2.21121947
18MP0005167_abnormal_blood-brain_barrier2.19357028
19MP0009384_cardiac_valve_regurgitation2.15069956
20MP0009780_abnormal_chondrocyte_physiolo2.13331105
21MP0003300_gastrointestinal_ulcer2.09599631
22MP0002877_abnormal_melanocyte_morpholog2.06688492
23MP0002837_dystrophic_cardiac_calcinosis2.05818229
24MP0010352_gastrointestinal_tract_polyps2.03556177
25MP0009250_abnormal_appendicular_skeleto2.03102295
26MP0000163_abnormal_cartilage_morphology2.01701749
27MP0004036_abnormal_muscle_relaxation2.00359654
28MP0005409_darkened_coat_color1.97900451
29MP0004134_abnormal_chest_morphology1.94071176
30MP0001879_abnormal_lymphatic_vessel1.82303897
31MP0005360_urolithiasis1.81213395
32MP0005395_other_phenotype1.75730021
33MP0004185_abnormal_adipocyte_glucose1.74207727
34MP0002933_joint_inflammation1.73668732
35MP0003950_abnormal_plasma_membrane1.73261712
36MP0001299_abnormal_eye_distance/1.72414011
37MP0004130_abnormal_muscle_cell1.72093476
38MP0008438_abnormal_cutaneous_collagen1.71953812
39MP0005670_abnormal_white_adipose1.71634646
40MP0002115_abnormal_skeleton_extremities1.65243299
41MP0002138_abnormal_hepatobiliary_system1.65044614
42MP0003279_aneurysm1.59009974
43MP0004233_abnormal_muscle_weight1.57625954
44MP0003566_abnormal_cell_adhesion1.56904140
45MP0008775_abnormal_heart_ventricle1.56888963
46MP0002896_abnormal_bone_mineralization1.56291765
47MP0006138_congestive_heart_failure1.54982944
48MP0004087_abnormal_muscle_fiber1.54663246
49MP0005666_abnormal_adipose_tissue1.53187143
50MP0005508_abnormal_skeleton_morphology1.52707809
51MP0002139_abnormal_hepatobiliary_system1.50889513
52MP0004215_abnormal_myocardial_fiber1.48864439
53MP0000767_abnormal_smooth_muscle1.44634334
54MP0006054_spinal_hemorrhage1.44414573
55MP0005023_abnormal_wound_healing1.44069520
56MP0002295_abnormal_pulmonary_circulatio1.43229876
57MP0004484_altered_response_of1.42744532
58MP0005623_abnormal_meninges_morphology1.41430114
59MP0002972_abnormal_cardiac_muscle1.39619030
60MP0000249_abnormal_blood_vessel1.36572232
61MP0005385_cardiovascular_system_phenoty1.36110441
62MP0001544_abnormal_cardiovascular_syste1.36110441
63MP0005275_abnormal_skin_tensile1.35931600
64MP0005620_abnormal_muscle_contractility1.33810978
65MP0000343_altered_response_to1.32195139
66MP0002089_abnormal_postnatal_growth/wei1.28137291
67MP0005187_abnormal_penis_morphology1.27002866
68MP0005330_cardiomyopathy1.23472781
69* MP0002113_abnormal_skeleton_development1.20745943
70MP0000750_abnormal_muscle_regeneration1.17987552
71MP0010630_abnormal_cardiac_muscle1.17293816
72MP0003091_abnormal_cell_migration1.17193588
73MP0002108_abnormal_muscle_morphology1.13976063
74MP0003941_abnormal_skin_development1.13755552
75MP0003283_abnormal_digestive_organ1.12018171
76MP0008961_abnormal_basal_metabolism1.11919114
77MP0002168_other_aberrant_phenotype1.11450206
78MP0000762_abnormal_tongue_morphology1.11165416
79MP0002269_muscular_atrophy1.08868237
80MP0003453_abnormal_keratinocyte_physiol1.08249140
81MP0003448_altered_tumor_morphology1.05868503
82MP0005058_abnormal_lysosome_morphology1.03124069
83MP0003252_abnormal_bile_duct1.03068058
84MP0005595_abnormal_vascular_smooth1.01946776
85MP0002116_abnormal_craniofacial_bone1.01692023
86MP0010155_abnormal_intestine_physiology1.01568025
87MP0002332_abnormal_exercise_endurance1.00982626
88MP0002109_abnormal_limb_morphology1.00651447
89MP0003935_abnormal_craniofacial_develop1.00474782
90MP0000749_muscle_degeneration0.99678609
91MP0003868_abnormal_feces_composition0.99594347
92MP0003879_abnormal_hair_cell0.99530829
93MP0005332_abnormal_amino_acid0.96486675
94MP0003942_abnormal_urinary_system0.96262323
95MP0004808_abnormal_hematopoietic_stem0.95139339
96MP0002106_abnormal_muscle_physiology0.94988736
97MP0000747_muscle_weakness0.94488523
98MP0000534_abnormal_ureter_morphology0.94172774
99MP0010030_abnormal_orbit_morphology0.94112449
100MP0000733_abnormal_muscle_development0.93996527
101MP0002998_abnormal_bone_remodeling0.92410047
102MP0002128_abnormal_blood_circulation0.92289611
103MP0005165_increased_susceptibility_to0.91892658
104MP0004085_abnormal_heartbeat0.89190813
105MP0005397_hematopoietic_system_phenotyp0.87551014
106MP0001545_abnormal_hematopoietic_system0.87551014
107MP0002932_abnormal_joint_morphology0.87516315
108MP0000230_abnormal_systemic_arterial0.87300312
109MP0005369_muscle_phenotype0.87266968
110MP0009643_abnormal_urine_homeostasis0.86993423
111MP0002909_abnormal_adrenal_gland0.86925463
112MP0003699_abnormal_female_reproductive0.86424736
113MP0002127_abnormal_cardiovascular_syste0.85152892
114MP0003075_altered_response_to0.84827028
115MP0005377_hearing/vestibular/ear_phenot0.84689416
116MP0003878_abnormal_ear_physiology0.84689416
117MP0009840_abnormal_foam_cell0.84451770
118MP0003183_abnormal_peptide_metabolism0.83772586
119MP0005390_skeleton_phenotype0.83700499
120MP0005375_adipose_tissue_phenotype0.83544082
121MP0002925_abnormal_cardiovascular_devel0.81817285
122MP0000759_abnormal_skeletal_muscle0.81779202
123MP0001765_abnormal_ion_homeostasis0.81051061
124MP0001915_intracranial_hemorrhage0.80988413
125MP0001270_distended_abdomen0.80793912
126MP0000432_abnormal_head_morphology0.80306264
127MP0005248_abnormal_Harderian_gland0.80219780
128MP0001730_embryonic_growth_arrest0.80007009
129MP0004782_abnormal_surfactant_physiolog0.79652630
130MP0001614_abnormal_blood_vessel0.79392059
131MP0009764_decreased_sensitivity_to0.76454237
132MP0000266_abnormal_heart_morphology0.76451312
133MP0005164_abnormal_response_to0.75811660
134MP0005621_abnormal_cell_physiology0.75357957
135MP0005501_abnormal_skin_physiology0.74823345
136MP0005410_abnormal_fertilization0.74821743
137MP0002133_abnormal_respiratory_system0.74656396
138MP0005388_respiratory_system_phenotype0.74656396
139MP0001851_eye_inflammation0.74159377
140MP0003191_abnormal_cellular_cholesterol0.74061357
141MP0001533_abnormal_skeleton_physiology0.73248350
142MP0002148_abnormal_hypersensitivity_rea0.73191022
143MP0001849_ear_inflammation0.72099552
144MP0000858_altered_metastatic_potential0.71887830
145MP0005000_abnormal_immune_tolerance0.71157096
146MP0001784_abnormal_fluid_regulation0.69856763
147MP0004947_skin_inflammation0.69744509
148MP0003436_decreased_susceptibility_to0.69387153
149MP0002419_abnormal_innate_immunity0.68897530
150MP0002086_abnormal_extraembryonic_tissu0.68695156
151MP0005380_embryogenesis_phenotype0.68070857
152MP0001672_abnormal_embryogenesis/_devel0.68070857
153MP0003984_embryonic_growth_retardation0.66521655
154MP0001835_abnormal_antigen_presentation0.66284097
155MP0008874_decreased_physiological_sensi0.63491452
156MP0005166_decreased_susceptibility_to0.63343775
157MP0002398_abnormal_bone_marrow0.60478917
158MP0005084_abnormal_gallbladder_morpholo0.59376999
159MP0002088_abnormal_embryonic_growth/wei0.58698080
160MP0005076_abnormal_cell_differentiation0.54285708
161MP0003045_fibrosis0.52139459
162MP0003656_abnormal_erythrocyte_physiolo0.49770714

Predicted human phenotypes

RankGene SetZ-score
1Menorrhagia (HP:0000132)8.08700391
2Increased mean platelet volume (HP:0011877)7.71687143
3Prolonged bleeding time (HP:0003010)7.48969918
4Abnormal platelet volume (HP:0011876)7.22522013
5Epiphyseal dysplasia (HP:0002656)7.10081253
6Spontaneous hematomas (HP:0007420)7.04570619
7Conjunctival telangiectasia (HP:0000524)5.93893293
8Petechiae (HP:0000967)5.91248309
9Irregular epiphyses (HP:0010582)5.79059013
10Purpura (HP:0000979)5.52697165
11Hypoplastic ischia (HP:0003175)5.44908924
12Vitreoretinal degeneration (HP:0000655)5.35314971
13Epistaxis (HP:0000421)5.32539846
14Metaphyseal cupping (HP:0003021)5.08224803
15Abnormality of the vasculature of the conjunctiva (HP:0008054)5.03837308
16Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.97064940
17Abnormal platelet function (HP:0011869)4.92321972
18Impaired platelet aggregation (HP:0003540)4.92321972
19Abnormality of the ischium (HP:0003174)4.85878618
20Delayed epiphyseal ossification (HP:0002663)4.49783885
21Flat capital femoral epiphysis (HP:0003370)4.48254566
22Hematochezia (HP:0002573)4.44702462
23Abnormal tarsal ossification (HP:0008369)4.36877354
24Small epiphyses (HP:0010585)4.10671089
25Cupped ribs (HP:0000887)4.03897122
26Genu varum (HP:0002970)4.00145087
27Flat acetabular roof (HP:0003180)3.97057535
28Metaphyseal dysplasia (HP:0100255)3.96940919
29Gingival bleeding (HP:0000225)3.82548044
30Wrist flexion contracture (HP:0001239)3.68251775
31Mild short stature (HP:0003502)3.65859633
32Esophageal varix (HP:0002040)3.49200464
33Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.48339857
34Abnormality of femoral epiphyses (HP:0006499)3.48339857
35Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.41981633
36Enlarged epiphyses (HP:0010580)3.33090964
37Cerebral hemorrhage (HP:0001342)3.28958768
38Abnormality of the epiphysis of the femoral head (HP:0010574)3.24649576
39Muscle fiber splitting (HP:0003555)3.20924986
40Abnormal foot bone ossification (HP:0010675)3.08255575
41Osteoarthritis (HP:0002758)3.07063398
42Exostoses (HP:0100777)3.02802957
43Portal hypertension (HP:0001409)2.96995605
44Abnormality of the femoral head (HP:0003368)2.95632541
45Abnormality of the pubic bones (HP:0003172)2.90969413
46Abnormality of the vertebral endplates (HP:0005106)2.89375603
47Neonatal short-limb short stature (HP:0008921)2.84747516
48Hyperlipoproteinemia (HP:0010980)2.79956264
49Hip contracture (HP:0003273)2.77771775
50Abnormality of the hepatic vasculature (HP:0006707)2.75556024
51Limited hip movement (HP:0008800)2.73481679
52Abnormal vertebral ossification (HP:0100569)2.73179930
53Papillary thyroid carcinoma (HP:0002895)2.71552774
54Coxa vara (HP:0002812)2.70543254
55Platyspondyly (HP:0000926)2.66831606
56Mucosal telangiectasiae (HP:0100579)2.65785128
57Waddling gait (HP:0002515)2.64568473
58Absent epiphyses (HP:0010577)2.62815470
59Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.62815470
60Protuberant abdomen (HP:0001538)2.61469793
61Irregular vertebral endplates (HP:0003301)2.60318653
62Flattened epiphyses (HP:0003071)2.50917132
63Joint hemorrhage (HP:0005261)2.50862660
64Abnormality of carpal bone ossification (HP:0006257)2.49820466
65Male infertility (HP:0003251)2.46215406
66Short femoral neck (HP:0100864)2.45746450
67Cervical subluxation (HP:0003308)2.45143367
68Apathy (HP:0000741)2.40084618
69Metaphyseal irregularity (HP:0003025)2.39435407
70Abnormality of the proximal phalanges of the hand (HP:0009834)2.38477504
71Ovoid vertebral bodies (HP:0003300)2.38102317
72Anterior segment dysgenesis (HP:0007700)2.35600758
73Bruising susceptibility (HP:0000978)2.32470924
74Myocardial infarction (HP:0001658)2.30945554
75Vertebral clefting (HP:0008428)2.30724911
76Tetraparesis (HP:0002273)2.28518097
77Abnormality of the nasal mucosa (HP:0000433)2.27595386
78Neonatal death (HP:0003811)2.26024788
79Abnormal hand bone ossification (HP:0010660)2.25989345
80Limited elbow extension (HP:0001377)2.25468219
81Abnormal ossification of hand bones (HP:0005921)2.24858646
82Broad metatarsal (HP:0001783)2.23627189
83Hemorrhage of the eye (HP:0011885)2.23398959
84Toxemia of pregnancy (HP:0100603)2.22012720
85Lumbar hyperlordosis (HP:0002938)2.21871526
86Diminished motivation (HP:0000745)2.20582161
87Stroke (HP:0001297)2.20218339
88Abnormality of the common coagulation pathway (HP:0010990)2.20084641
89Spinal rigidity (HP:0003306)2.19597034
90Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.18624381
91Abnormality of the phalanges of the 2nd finger (HP:0009541)2.16496380
92Barrel-shaped chest (HP:0001552)2.15699049
93Skull defect (HP:0001362)2.13710391
94Absent hand (HP:0004050)2.10919045
95Hypoplasia of the odontoid process (HP:0003311)2.07269310
96Hypophosphatemic rickets (HP:0004912)2.05823784
97Abnormality of macrophages (HP:0004311)2.04932228
98Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.04614677
99Capillary hemangiomas (HP:0005306)2.03598222
100Mixed hearing impairment (HP:0000410)2.02143178
101Arthropathy (HP:0003040)2.00670778
102Beaking of vertebral bodies (HP:0004568)2.00555711
103Striae distensae (HP:0001065)1.99649274
104Exercise-induced myalgia (HP:0003738)1.99094503
105Increased connective tissue (HP:0009025)1.98904505
106Carpal bone hypoplasia (HP:0001498)1.97789807
107Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.97569727
108Visceral angiomatosis (HP:0100761)1.97274579
109Leiomyosarcoma (HP:0100243)1.95453732
110Uterine leiomyosarcoma (HP:0002891)1.95453732
111Arterial tortuosity (HP:0005116)1.94779556
112Abnormal auditory evoked potentials (HP:0006958)1.94277636
113Shallow orbits (HP:0000586)1.91394903
114Lymphangioma (HP:0100764)1.91014793
115Hydroxyprolinuria (HP:0003080)1.90754283
116Abnormality of proline metabolism (HP:0010907)1.90754283
117Polycythemia (HP:0001901)1.89897337
118Subcapsular cataract (HP:0000523)1.89524358
119Hypoplasia of the iris (HP:0007676)1.89197380
120Premature rupture of membranes (HP:0001788)1.88506378
121Thin ribs (HP:0000883)1.87357265
122Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.86973318
123Hemangiomatosis (HP:0007461)1.86705466
124Short middle phalanx of finger (HP:0005819)1.86247395
125Increased density of long bones (HP:0006392)1.86132667
126Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.85377259
127Aplasia/hypoplasia of the femur (HP:0005613)1.85213786
128Vascular tortuosity (HP:0004948)1.84585701
129Abnormality of the middle phalanges of the toes (HP:0010183)1.84549367
130Sudden death (HP:0001699)1.82766810
131Protrusio acetabuli (HP:0003179)1.80630690
132Broad phalanx (HP:0006009)1.79830111
133Spinal cord compression (HP:0002176)1.79297009
134Cerebral aneurysm (HP:0004944)1.78699945
135Hyporeflexia of lower limbs (HP:0002600)1.78385985
136Overgrowth (HP:0001548)1.77228283
137Aortic valve stenosis (HP:0001650)1.77147259
138Distal lower limb amyotrophy (HP:0008944)1.76855400
139Mesomelia (HP:0003027)1.75904883
140Hyperactive renin-angiotensin system (HP:0000841)1.74987313
141Hyperuricemia (HP:0002149)1.74425421
142Increased purine levels (HP:0004368)1.74425421
143Abnormality of the middle phalanges of the hand (HP:0009833)1.73581429
144Abnormality of the intrinsic pathway (HP:0010989)1.73222778
145Mitral valve prolapse (HP:0001634)1.73191717
146Distal lower limb muscle weakness (HP:0009053)1.72845621
147Stillbirth (HP:0003826)1.71962925
148Abnormality of the acetabulum (HP:0003170)1.69574701
149Thoracolumbar scoliosis (HP:0002944)1.69547005
150Dyschromatopsia (HP:0007641)1.69394290
151Hypoplasia of the fovea (HP:0007750)1.69301958
152Aplasia/Hypoplasia of the fovea (HP:0008060)1.69301958
153Ankyloglossia (HP:0010296)1.68995614
154Abnormal cartilage morphology (HP:0002763)1.68984459
155Aortic aneurysm (HP:0004942)1.68612074
156Gout (HP:0001997)1.68020334
157Micromelia (HP:0002983)1.67092245
158Abnormality of the anterior chamber (HP:0000593)1.66865027
159Abnormality of the vitreous humor (HP:0004327)1.66614744
160Abnormality of the 2nd finger (HP:0004100)1.66453323
161Broad long bones (HP:0005622)1.66345265
162Deep venous thrombosis (HP:0002625)1.66061736
163Wormian bones (HP:0002645)1.65695260
164Rhizomelia (HP:0008905)1.65565848
165Flared metaphyses (HP:0003015)1.64848405
166Porencephaly (HP:0002132)1.63625752
167Reduced subcutaneous adipose tissue (HP:0003758)1.63568280
168Facial hemangioma (HP:0000329)1.61127193
169Transitional cell carcinoma of the bladder (HP:0006740)1.60808890
170Poikilocytosis (HP:0004447)1.60636005
171Hypercortisolism (HP:0001578)1.60609704
172Dysostosis multiplex (HP:0000943)1.59828844
173Hydroureter (HP:0000072)1.59731368
174Osteomalacia (HP:0002749)1.58733413
175Infertility (HP:0000789)1.58584586
176Cholecystitis (HP:0001082)1.58338493
177Abnormal gallbladder physiology (HP:0012438)1.58338493
178Abnormality of oral frenula (HP:0000190)1.55553217
179Aplasia/Hypoplasia of the macula (HP:0008059)1.53167193
180Aortic dissection (HP:0002647)1.53143792
181Lip pit (HP:0100267)1.52666792
182Cavernous hemangioma (HP:0001048)1.50881339
183Loss of speech (HP:0002371)1.49937213
184Bladder carcinoma (HP:0002862)1.49638862
185Bladder neoplasm (HP:0009725)1.49638862
186Renal cell carcinoma (HP:0005584)1.49457366

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.23722813
2DDR24.02142588
3STK38L3.64449563
4BMPR23.48447198
5TIE13.29258784
6TRIB33.20203689
7LATS23.17210140
8DMPK2.97704099
9ARAF2.64543910
10FES2.46215400
11MAP3K132.30645390
12TEC2.28999394
13IRAK32.18231228
14MAP3K32.18178056
15WNK42.07448563
16STK242.01192052
17RIPK41.99781102
18EPHB21.95640639
19TAOK11.92435982
20BMX1.85047575
21TTN1.84406140
22TGFBR21.83517449
23CDK121.78436052
24PHKG21.59237422
25PHKG11.59237422
26MAP3K61.53837498
27RIPK11.52920061
28ZAP701.52832029
29PRKD31.49373206
30LMTK21.45412048
31STK31.42651345
32KSR21.35024476
33CSK1.31509092
34FGFR41.25108757
35BTK1.20032818
36EPHA31.17973323
37MOS1.16765047
38EPHB11.15264364
39EIF2AK11.15247349
40BRAF1.11888187
41PDGFRA1.11625467
42EEF2K1.10234777
43GSK3A1.10184541
44PKN21.08774649
45HCK1.07026652
46PAK31.06439286
47ERBB41.01688105
48SIK11.00106975
49MST40.98109847
50PIK3CA0.97446651
51ROCK10.97357767
52FER0.95791509
53RET0.95116886
54PRKG20.93905296
55PINK10.92089688
56NEK60.92008993
57JAK30.90314488
58AURKA0.90156418
59PAK60.88658020
60PDK10.87408772
61STK380.87355005
62PAK40.85282071
63TGFBR10.83101129
64PDK20.82221153
65MAPK150.81811223
66GRK50.80268608
67PTK60.80144470
68PRKD20.79892677
69PRKD10.79569080
70FGFR30.78487759
71NUAK10.77839195
72PRKAA10.77510934
73PDGFRB0.76475689
74TAOK20.75573481
75PIK3CG0.72484186
76LRRK20.71561260
77ERN10.70809100
78STK100.70799296
79PAK10.69948470
80MAP3K90.69201998
81FGR0.68994160
82STK390.68934856
83PRPF4B0.67494413
84MARK20.66429752
85SGK30.66310666
86PRKCH0.66304483
87CDK90.65559704
88ITK0.65352020
89MAP3K50.64856026
90MAP3K10.64843244
91PTK2B0.64254480
92PLK20.64061794
93PDK30.62921364
94PDK40.62921364
95SYK0.62777792
96ILK0.61897004
97IRAK20.61595537
98MAP2K10.61374044
99FGFR20.61240646
100MAPK120.61188823
101MYLK0.61097122
102OXSR10.59597512
103PTK20.59511674
104ROCK20.58951244
105KSR10.58431796
106MTOR0.57257327
107IRAK10.56129142
108WNK10.55515038
109FGFR10.55229483
110MAP3K80.52944865
111NTRK10.52686734
112CDK80.52474365
113PRKAA20.52190712
114IRAK40.51215056
115CSF1R0.50897374
116MAPKAPK30.49906334
117PIM10.48510483
118TYRO30.47877511
119PIM20.47430853
120MAP3K70.47034823
121CAMK1G0.46954313
122BCKDK0.46593222
123TRPM70.45757968
124NEK90.44581762
125MAP3K140.44103733
126OBSCN0.41455283
127TAOK30.41449634
128RAF10.38321468
129MUSK0.37733404
130MET0.36461332
131SGK2230.36134848
132SGK4940.36134848
133WNK30.36112787
134MELK0.35655589
135KDR0.35626112
136MAP3K20.35332909
137MAPK110.34898279
138PDPK10.34691176
139MAP2K30.33721970
140IKBKB0.33241286
141CDC42BPA0.32774611
142MAP3K110.31901646
143MARK30.31234788
144BLK0.30429130
145LYN0.29292665
146DAPK30.28235605
147LCK0.26663882
148SRC0.25971813

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.26029022
2Protein digestion and absorption_Homo sapiens_hsa049742.54415758
3Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.47126332
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.46540042
5Focal adhesion_Homo sapiens_hsa045101.99811612
6Fatty acid degradation_Homo sapiens_hsa000711.97110117
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.94716526
8Malaria_Homo sapiens_hsa051441.92710909
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.88215211
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.80578409
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.79865876
12Dilated cardiomyopathy_Homo sapiens_hsa054141.74485502
13Propanoate metabolism_Homo sapiens_hsa006401.69146344
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.67948907
15Fatty acid metabolism_Homo sapiens_hsa012121.60368828
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.58781374
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.55101144
18Nitrogen metabolism_Homo sapiens_hsa009101.54038523
19Hematopoietic cell lineage_Homo sapiens_hsa046401.51030160
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.46459060
21PPAR signaling pathway_Homo sapiens_hsa033201.44890466
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40351557
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.39284866
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.37035227
25Shigellosis_Homo sapiens_hsa051311.33265580
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.32423365
27Chemokine signaling pathway_Homo sapiens_hsa040621.30887146
28Phospholipase D signaling pathway_Homo sapiens_hsa040721.28382982
29* Hippo signaling pathway_Homo sapiens_hsa043901.27858244
30Osteoclast differentiation_Homo sapiens_hsa043801.27788531
31Butanoate metabolism_Homo sapiens_hsa006501.26056624
32Bile secretion_Homo sapiens_hsa049761.23480097
33Chronic myeloid leukemia_Homo sapiens_hsa052201.22279415
34* TGF-beta signaling pathway_Homo sapiens_hsa043501.21092602
35Adherens junction_Homo sapiens_hsa045201.18243089
36Lysine degradation_Homo sapiens_hsa003101.17908381
37Dorso-ventral axis formation_Homo sapiens_hsa043201.17675453
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.16316817
39Thyroid cancer_Homo sapiens_hsa052161.14058063
40Cell cycle_Homo sapiens_hsa041101.13738747
41Endocytosis_Homo sapiens_hsa041441.13481197
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13455637
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12685517
44Proteoglycans in cancer_Homo sapiens_hsa052051.11624795
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08681892
46Tryptophan metabolism_Homo sapiens_hsa003801.08646003
47Basal cell carcinoma_Homo sapiens_hsa052171.08611784
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08196077
49Phagosome_Homo sapiens_hsa041451.06947041
50Pancreatic cancer_Homo sapiens_hsa052121.06798770
51Hedgehog signaling pathway_Homo sapiens_hsa043401.06710906
52Toxoplasmosis_Homo sapiens_hsa051451.05931686
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04845456
54TNF signaling pathway_Homo sapiens_hsa046681.04188688
55B cell receptor signaling pathway_Homo sapiens_hsa046621.02603134
56Fatty acid biosynthesis_Homo sapiens_hsa000611.02434604
57PI3K-Akt signaling pathway_Homo sapiens_hsa041511.01169509
58Circadian rhythm_Homo sapiens_hsa047101.01069687
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00081990
60Arginine biosynthesis_Homo sapiens_hsa002200.99759837
61* Ovarian steroidogenesis_Homo sapiens_hsa049130.99073603
62Insulin resistance_Homo sapiens_hsa049310.98784773
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.98768183
64HIF-1 signaling pathway_Homo sapiens_hsa040660.98018526
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.97382458
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94895275
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93997987
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.93049301
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92670657
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92606730
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91227809
72Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.89596002
73Renal cell carcinoma_Homo sapiens_hsa052110.88607376
74Small cell lung cancer_Homo sapiens_hsa052220.88009074
75beta-Alanine metabolism_Homo sapiens_hsa004100.87657497
76Non-small cell lung cancer_Homo sapiens_hsa052230.87567458
77Pyruvate metabolism_Homo sapiens_hsa006200.87546648
78Inositol phosphate metabolism_Homo sapiens_hsa005620.86545858
79FoxO signaling pathway_Homo sapiens_hsa040680.84781598
80Amoebiasis_Homo sapiens_hsa051460.84684816
81AMPK signaling pathway_Homo sapiens_hsa041520.84284987
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83329129
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83322507
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.83219615
85Starch and sucrose metabolism_Homo sapiens_hsa005000.83190136
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82994124
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82862750
88Olfactory transduction_Homo sapiens_hsa047400.82186236
89Hepatitis B_Homo sapiens_hsa051610.81836149
90Long-term depression_Homo sapiens_hsa047300.81394832
91Viral carcinogenesis_Homo sapiens_hsa052030.80701055
92p53 signaling pathway_Homo sapiens_hsa041150.79643985
93Ras signaling pathway_Homo sapiens_hsa040140.79228772
94Vitamin digestion and absorption_Homo sapiens_hsa049770.78489757
95Salmonella infection_Homo sapiens_hsa051320.77932399
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77052399
97Leishmaniasis_Homo sapiens_hsa051400.76107599
98Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.75908717
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.75417881
100Gastric acid secretion_Homo sapiens_hsa049710.73625744
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.73362555
102African trypanosomiasis_Homo sapiens_hsa051430.73125774
103Arginine and proline metabolism_Homo sapiens_hsa003300.72736766
104Influenza A_Homo sapiens_hsa051640.72459328
105Serotonergic synapse_Homo sapiens_hsa047260.71958432
106Acute myeloid leukemia_Homo sapiens_hsa052210.70431658
107NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70116713
108Endometrial cancer_Homo sapiens_hsa052130.68420533
109Apoptosis_Homo sapiens_hsa042100.67869319
110VEGF signaling pathway_Homo sapiens_hsa043700.67812331
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67755312
112GnRH signaling pathway_Homo sapiens_hsa049120.67152157
113Pertussis_Homo sapiens_hsa051330.67087444
114Tight junction_Homo sapiens_hsa045300.66600864
115MicroRNAs in cancer_Homo sapiens_hsa052060.66479751
116Notch signaling pathway_Homo sapiens_hsa043300.66074673
117Carbon metabolism_Homo sapiens_hsa012000.64205493
118Wnt signaling pathway_Homo sapiens_hsa043100.63523258
119NF-kappa B signaling pathway_Homo sapiens_hsa040640.63346293
120ErbB signaling pathway_Homo sapiens_hsa040120.63341835
121Rap1 signaling pathway_Homo sapiens_hsa040150.62771069
122T cell receptor signaling pathway_Homo sapiens_hsa046600.62748925
123cAMP signaling pathway_Homo sapiens_hsa040240.62711376
124Prostate cancer_Homo sapiens_hsa052150.62608151
125Glucagon signaling pathway_Homo sapiens_hsa049220.61107152
126mTOR signaling pathway_Homo sapiens_hsa041500.60667701
127Insulin signaling pathway_Homo sapiens_hsa049100.60660465
128Viral myocarditis_Homo sapiens_hsa054160.60625737
129Peroxisome_Homo sapiens_hsa041460.60457412
130Alcoholism_Homo sapiens_hsa050340.59593522
131Systemic lupus erythematosus_Homo sapiens_hsa053220.58663591
132Axon guidance_Homo sapiens_hsa043600.58372126
133Complement and coagulation cascades_Homo sapiens_hsa046100.58028660
134Oxytocin signaling pathway_Homo sapiens_hsa049210.57205273
135Renin secretion_Homo sapiens_hsa049240.56940817
136Estrogen signaling pathway_Homo sapiens_hsa049150.56625548
137Oocyte meiosis_Homo sapiens_hsa041140.56484398
138RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56252399
139Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56193011
140Glioma_Homo sapiens_hsa052140.55686256
141Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54768475
142Vascular smooth muscle contraction_Homo sapiens_hsa042700.54207127
143Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54055031
144Thyroid hormone synthesis_Homo sapiens_hsa049180.54051424
145MAPK signaling pathway_Homo sapiens_hsa040100.53936247
146Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53656214
147Prion diseases_Homo sapiens_hsa050200.53595842
148Choline metabolism in cancer_Homo sapiens_hsa052310.53075131
149Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52966308
150Measles_Homo sapiens_hsa051620.52609829
151Tuberculosis_Homo sapiens_hsa051520.52389105
152Legionellosis_Homo sapiens_hsa051340.52293888
153Jak-STAT signaling pathway_Homo sapiens_hsa046300.52007521
154Primary bile acid biosynthesis_Homo sapiens_hsa001200.51800062
155Gap junction_Homo sapiens_hsa045400.51702939
156Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51562771
157Colorectal cancer_Homo sapiens_hsa052100.50653324
158Platelet activation_Homo sapiens_hsa046110.50106012
159Bladder cancer_Homo sapiens_hsa052190.49701784
160Melanogenesis_Homo sapiens_hsa049160.49628456
161Pathways in cancer_Homo sapiens_hsa052000.49540577
162HTLV-I infection_Homo sapiens_hsa051660.48666602
163Leukocyte transendothelial migration_Homo sapiens_hsa046700.48663297

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »