BMP7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lateral sprouting from an epithelium (GO:0060601)5.68498853
2planar cell polarity pathway involved in neural tube closure (GO:0090179)4.68361471
3desmosome organization (GO:0002934)4.58752605
4establishment of planar polarity (GO:0001736)4.53841102
5establishment of tissue polarity (GO:0007164)4.53841102
6* regulation of mesenchymal cell apoptotic process (GO:2001053)4.43829094
7regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.38883819
8glomerular basement membrane development (GO:0032836)4.25826455
9pattern specification involved in kidney development (GO:0061004)4.17044078
10* mesenchyme morphogenesis (GO:0072132)4.15821775
11endocardial cushion morphogenesis (GO:0003203)4.15240611
12outflow tract septum morphogenesis (GO:0003148)4.06067709
13* negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.04456650
14G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.03235987
15negative regulation of axon guidance (GO:1902668)3.96726894
16ribosomal small subunit biogenesis (GO:0042274)3.93865587
17* mesenchymal cell proliferation (GO:0010463)3.91146553
18regulation of somitogenesis (GO:0014807)3.89399671
19ear development (GO:0043583)3.82683869
20epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.76096372
21cochlea morphogenesis (GO:0090103)3.72994937
22viral transcription (GO:0019083)3.71145562
23* cell proliferation involved in kidney development (GO:0072111)3.71061996
24hemidesmosome assembly (GO:0031581)3.69034948
25regulation of cardioblast differentiation (GO:0051890)3.68625794
26negative regulation of axon extension involved in axon guidance (GO:0048843)3.63737090
27outer ear morphogenesis (GO:0042473)3.62708125
28Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.62152685
29paraxial mesoderm development (GO:0048339)3.61702297
30non-canonical Wnt signaling pathway (GO:0035567)3.60863461
31glomerular epithelial cell development (GO:0072310)3.59050120
32exocrine pancreas development (GO:0031017)3.58626447
33regulation of transforming growth factor beta2 production (GO:0032909)3.57360361
34hepatocyte apoptotic process (GO:0097284)3.56320942
35regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.54518852
36mesenchymal cell differentiation involved in kidney development (GO:0072161)3.51641660
37mesenchymal cell differentiation involved in renal system development (GO:2001012)3.51641660
38translational termination (GO:0006415)3.50598305
39* cell proliferation involved in metanephros development (GO:0072203)3.49685449
40regulation of establishment of planar polarity (GO:0090175)3.48827540
41kidney mesenchyme development (GO:0072074)3.48756987
42regulation of non-canonical Wnt signaling pathway (GO:2000050)3.47253367
43cell surface receptor signaling pathway involved in heart development (GO:0061311)3.45758307
44glomerulus development (GO:0032835)3.39198284
45face development (GO:0060324)3.37715357
46cardiac right ventricle morphogenesis (GO:0003215)3.36255451
47bone trabecula formation (GO:0060346)3.35639577
48neuron projection extension involved in neuron projection guidance (GO:1902284)3.34515207
49axon extension involved in axon guidance (GO:0048846)3.34515207
50dorsal/ventral neural tube patterning (GO:0021904)3.33311168
51positive regulation of gastrulation (GO:2000543)3.32022309
52mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.31122996
53maturation of SSU-rRNA (GO:0030490)3.29985601
54atrioventricular valve morphogenesis (GO:0003181)3.29284430
55regulation of cardioblast proliferation (GO:0003264)3.27568728
56regulation of secondary heart field cardioblast proliferation (GO:0003266)3.27568728
57regulation of heart morphogenesis (GO:2000826)3.23445876
58daunorubicin metabolic process (GO:0044597)3.22578655
59polyketide metabolic process (GO:0030638)3.22578655
60doxorubicin metabolic process (GO:0044598)3.22578655
61heart valve formation (GO:0003188)3.20853318
62translational elongation (GO:0006414)3.20005618
63* mesonephros development (GO:0001823)3.17125862
64* regulation of organ formation (GO:0003156)3.15888287
65aminoglycoside antibiotic metabolic process (GO:0030647)3.15805892
66neurotransmitter catabolic process (GO:0042135)3.15240076
67cardiac myofibril assembly (GO:0055003)3.13341134
68glomerular visceral epithelial cell development (GO:0072015)3.13286276
69positive regulation of protein kinase C signaling (GO:0090037)3.12790908
70negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.10870631
71head development (GO:0060322)3.10783367
72negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.10607064
73dopaminergic neuron differentiation (GO:0071542)3.10239674
74regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.09786003
75lung-associated mesenchyme development (GO:0060484)3.07346460
76limb bud formation (GO:0060174)3.06289311
77asymmetric protein localization (GO:0008105)3.03100420
78bundle of His cell to Purkinje myocyte communication (GO:0086069)3.00959860
79nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.00125636
80hindlimb morphogenesis (GO:0035137)2.98109691
81peptidyl-arginine omega-N-methylation (GO:0035247)2.98056830
82positive regulation of interleukin-8 secretion (GO:2000484)2.97428607
83midbrain development (GO:0030901)2.97228998
84negative chemotaxis (GO:0050919)2.97000808
85cardiac epithelial to mesenchymal transition (GO:0060317)2.96814976
86negative regulation of stem cell proliferation (GO:2000647)2.93339099
87apical protein localization (GO:0045176)2.92252964
88negative regulation of cell fate specification (GO:0009996)2.91866854
89regulation of centriole replication (GO:0046599)2.91179040
90embryonic forelimb morphogenesis (GO:0035115)2.90731814
91mesenchymal cell development (GO:0014031)2.88616476
92neural crest cell development (GO:0014032)2.88012225
93ribosomal small subunit assembly (GO:0000028)2.87302281
94heart valve morphogenesis (GO:0003179)2.86410763
95SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.86311585
96cotranslational protein targeting to membrane (GO:0006613)2.85701783
97embryonic hindlimb morphogenesis (GO:0035116)2.85568146
98negative regulation of chondrocyte differentiation (GO:0032331)2.84861719
99cell differentiation involved in metanephros development (GO:0072202)2.84486768
100positive regulation of embryonic development (GO:0040019)2.83625639
101negative regulation of keratinocyte proliferation (GO:0010839)2.83194794
102cranial nerve morphogenesis (GO:0021602)2.83077273
103cell migration in hindbrain (GO:0021535)2.82868897
104negative regulation of cell fate commitment (GO:0010454)2.82825286
105convergent extension (GO:0060026)2.82174912
106glomerular filtration (GO:0003094)2.81722479
107protein targeting to ER (GO:0045047)2.79433946
108notochord development (GO:0030903)2.79338777
109forelimb morphogenesis (GO:0035136)2.78551761
110regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.76705551
111stem cell development (GO:0048864)2.75234136
112cell migration involved in heart development (GO:0060973)2.73996871
113regulation of chemokine-mediated signaling pathway (GO:0070099)2.73706404
114* mesenchyme development (GO:0060485)2.72974035
115cellular protein complex disassembly (GO:0043624)2.72477768
116regulation of mesoderm development (GO:2000380)2.71480580
117renal filtration (GO:0097205)2.71155769
118viral life cycle (GO:0019058)2.70882593
119ectodermal placode formation (GO:0060788)2.70359371
120regulation of male gonad development (GO:2000018)2.69297368
121somatic stem cell division (GO:0048103)2.69232142
122mesenchymal to epithelial transition (GO:0060231)2.68860628
123* regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.68763106
124postsynaptic membrane organization (GO:0001941)2.68189727
125establishment of protein localization to endoplasmic reticulum (GO:0072599)2.67620614
126* mesenchymal cell differentiation (GO:0048762)2.67270631
127hair cycle (GO:0042633)2.66720532
128molting cycle (GO:0042303)2.66720532
129protein complex disassembly (GO:0043241)2.65522201
130chondrocyte development (GO:0002063)2.63965018
131branching involved in ureteric bud morphogenesis (GO:0001658)2.63433255
132lens fiber cell development (GO:0070307)2.63068190
133hair follicle development (GO:0001942)2.61205239
134embryonic foregut morphogenesis (GO:0048617)2.57791219
135protein localization to endoplasmic reticulum (GO:0070972)2.57404796
136peptidyl-arginine methylation (GO:0018216)2.57102581
137peptidyl-arginine N-methylation (GO:0035246)2.57102581
138adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.55278513
139negative regulation of catenin import into nucleus (GO:0035414)2.51476495
140cell differentiation involved in embryonic placenta development (GO:0060706)2.48677999
141protein-DNA complex disassembly (GO:0032986)2.45326758
142nucleosome disassembly (GO:0006337)2.45326758
143macromolecular complex disassembly (GO:0032984)2.44922253
144behavioral response to cocaine (GO:0048148)2.44321202
145response to parathyroid hormone (GO:0071107)2.43487368
146translational initiation (GO:0006413)2.42663640
147presynaptic membrane assembly (GO:0097105)2.42113372
148response to water (GO:0009415)2.41823416
149transmission of nerve impulse (GO:0019226)2.36614760
150histone arginine methylation (GO:0034969)2.35692321
151epithelial tube branching involved in lung morphogenesis (GO:0060441)2.33721440
152dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.32818818
153positive regulation of catenin import into nucleus (GO:0035413)2.29386755
154negative regulation of epidermis development (GO:0045683)2.28834000
155chaperone-mediated protein complex assembly (GO:0051131)2.28026879
156regulation of catenin import into nucleus (GO:0035412)2.27099712
157RNA localization (GO:0006403)2.26901560
158ephrin receptor signaling pathway (GO:0048013)2.24569295
159maternal placenta development (GO:0001893)2.23929001
160cell-cell signaling involved in cell fate commitment (GO:0045168)2.22373906
161neuronal stem cell maintenance (GO:0097150)2.22307681
162negative regulation of organelle assembly (GO:1902116)2.21518220
163vagina development (GO:0060068)2.21499479
164regulation of axon guidance (GO:1902667)2.20450748
165norepinephrine metabolic process (GO:0042415)2.18555986
166cell proliferation in forebrain (GO:0021846)2.18243467
167* branching involved in salivary gland morphogenesis (GO:0060445)2.18139176
168mammary gland epithelial cell differentiation (GO:0060644)2.17328398

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* TP63_17297297_ChIP-ChIP_HaCaT_Human5.09098693
2ESR1_15608294_ChIP-ChIP_MCF-7_Human3.64239032
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.54679556
4* EED_16625203_ChIP-ChIP_MESCs_Mouse3.46002914
5* PHC1_16625203_ChIP-ChIP_MESCs_Mouse3.18213169
6* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.01849787
7* EZH2_27304074_Chip-Seq_ESCs_Mouse2.85109118
8TP63_19390658_ChIP-ChIP_HaCaT_Human2.79364871
9* ESR2_21235772_ChIP-Seq_MCF-7_Human2.77875850
10* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.74613120
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.72344423
12* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.72181813
13* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.72181813
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.71524623
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.68568251
16* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.66309509
17* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.63823237
18* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.61822046
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.57443374
20BMI1_23680149_ChIP-Seq_NPCS_Mouse2.45585833
21* CBX2_27304074_Chip-Seq_ESCs_Mouse2.45152040
22TRIM28_21343339_ChIP-Seq_HEK293_Human2.36906231
23BP1_19119308_ChIP-ChIP_Hs578T_Human2.33849021
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.31776530
25MYC_18555785_ChIP-Seq_MESCs_Mouse2.31181193
26* RNF2_27304074_Chip-Seq_ESCs_Mouse2.27595851
27* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.27116805
28* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.25300232
29TP53_20018659_ChIP-ChIP_R1E_Mouse2.21738737
30* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.15174599
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.12731953
32EP300_21415370_ChIP-Seq_HL-1_Mouse2.08788461
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05702094
34* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.05324311
35* POU5F1_16153702_ChIP-ChIP_HESCs_Human2.04672116
36EZH2_22144423_ChIP-Seq_EOC_Human2.02139828
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97570130
38HIF1A_21447827_ChIP-Seq_MCF-7_Human1.96095691
39* EZH2_27294783_Chip-Seq_ESCs_Mouse1.94514594
40E2F7_22180533_ChIP-Seq_HELA_Human1.91704135
41* RUNX1_27514584_Chip-Seq_MCF-7_Human1.86908058
42ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.85489235
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.85483068
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.85009518
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.83423638
46* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.80737845
47WT1_19549856_ChIP-ChIP_CCG9911_Human1.80292761
48XRN2_22483619_ChIP-Seq_HELA_Human1.75541053
49GBX2_23144817_ChIP-Seq_PC3_Human1.70245175
50ZNF263_19887448_ChIP-Seq_K562_Human1.69819272
51* ESR1_21235772_ChIP-Seq_MCF-7_Human1.69135502
52* ISL1_27105846_Chip-Seq_CPCs_Mouse1.67262056
53KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.66631540
54* RACK7_27058665_Chip-Seq_MCF-7_Human1.65241353
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.64858639
56* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.61864775
57ZNF217_24962896_ChIP-Seq_MCF-7_Human1.60658603
58* RING1B_27294783_Chip-Seq_NPCs_Mouse1.60043331
59MYC_19079543_ChIP-ChIP_MESCs_Mouse1.59248507
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.56070892
61* RING1B_27294783_Chip-Seq_ESCs_Mouse1.53436407
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.52876168
63* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.52719381
64SOX9_24532713_ChIP-Seq_HFSC_Mouse1.51840321
65* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.51406003
66CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.50316887
67RNF2_27304074_Chip-Seq_NSC_Mouse1.49515691
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46104255
69ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.43648694
70STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43589518
71PKCTHETA_26484144_Chip-Seq_BREAST_Human1.42427244
72* TP53_18474530_ChIP-ChIP_U2OS_Human1.41814329
73* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.41155664
74AHR_22903824_ChIP-Seq_MCF-7_Human1.40744671
75E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.37657556
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.34558906
77* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33457016
78RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.33422579
79EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32855768
80KDM5A_27292631_Chip-Seq_BREAST_Human1.32593007
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31590101
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30450143
83NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.28763940
84TDRD3_21172665_ChIP-Seq_MCF-7_Human1.27085905
85* ARNT_22903824_ChIP-Seq_MCF-7_Human1.26284003
86* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25943218
87* SMAD3_21741376_ChIP-Seq_EPCs_Human1.22469114
88POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22258247
89CJUN_26792858_Chip-Seq_BT549_Human1.21629423
90CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18845895
91MYC_18358816_ChIP-ChIP_MESCs_Mouse1.17746875
92AR_21572438_ChIP-Seq_LNCaP_Human1.16498981
93KDM2B_26808549_Chip-Seq_K562_Human1.15886058
94* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.15575398
95* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.14487845
96MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.14141402
97* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.13611389
98POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.11755748
99EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.11082317
100ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10741151
101* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10703737
102ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10011546
103P300_19829295_ChIP-Seq_ESCs_Human1.09385308
104ESR1_20079471_ChIP-ChIP_T-47D_Human1.08595229
105* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07460615
106THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06810637
107POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05873588
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05873588
109CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.05365041
110SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04934570
111ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04921910
112CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03349945
113NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01847135
114VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01525590
115* SMAD3_21741376_ChIP-Seq_HESCs_Human1.01505733
116* ER_23166858_ChIP-Seq_MCF-7_Human1.01008158
117DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00249286
118AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99954299
119* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99920837
120TCF4_18268006_ChIP-ChIP_LS174T_Human0.99357041
121CDX2_20551321_ChIP-Seq_CACO-2_Human0.98171308
122MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.97859809
123FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97817635
124* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97268279
125CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96538397
126VDR_24787735_ChIP-Seq_THP-1_Human0.96423021
127EWS_26573619_Chip-Seq_HEK293_Human0.96126933
128TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95983248
129TET1_21451524_ChIP-Seq_MESCs_Mouse0.95526673
130SOX3_22085726_ChIP-Seq_NPCs_Mouse0.95490169
131* GATA3_24758297_ChIP-Seq_MCF-7_Human0.95414852
132POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94954000
133LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94612036
134TTF2_22483619_ChIP-Seq_HELA_Human0.94536809
135AR_21909140_ChIP-Seq_LNCAP_Human0.94168241
136THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93467553
137RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92495196
138* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91891327
139CTCF_18555785_ChIP-Seq_MESCs_Mouse0.91864276
140IGF1R_20145208_ChIP-Seq_DFB_Human0.91341628
141* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90380602
142* RXR_22108803_ChIP-Seq_LS180_Human0.90234259
143NELFA_20434984_ChIP-Seq_ESCs_Mouse0.90023500
144* SOX2_16153702_ChIP-ChIP_HESCs_Human0.89962472
145* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89913355
146FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89147852
147SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.87988112
148CTCF_27219007_Chip-Seq_Bcells_Human0.87469420
149LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87434627
150TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87338151
151* SMAD4_21741376_ChIP-Seq_HESCs_Human0.86051741
152* SOX2_20726797_ChIP-Seq_SW620_Human0.86020375
153DROSHA_22980978_ChIP-Seq_HELA_Human0.85681261
154CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.85587309
155* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.84555063
156SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.81763973
157* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.80503911
158* E2F1_18555785_Chip-Seq_ESCs_Mouse0.79393860
159SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79386489
160TBL1_22424771_ChIP-Seq_293T_Human0.78334466
161* NANOG_18555785_Chip-Seq_ESCs_Mouse0.78237518
162TAF15_26573619_Chip-Seq_HEK293_Human0.78138924

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis3.91723248
2MP0003941_abnormal_skin_development3.69985848
3MP0010030_abnormal_orbit_morphology3.56336555
4MP0009053_abnormal_anal_canal2.96695046
5MP0000383_abnormal_hair_follicle2.76862136
6MP0000579_abnormal_nail_morphology2.76081701
7MP0003122_maternal_imprinting2.74838204
8MP0000762_abnormal_tongue_morphology2.67020172
9MP0005377_hearing/vestibular/ear_phenot2.59657352
10MP0003878_abnormal_ear_physiology2.59657352
11MP0000537_abnormal_urethra_morphology2.55157468
12MP0003385_abnormal_body_wall2.45219253
13* MP0003942_abnormal_urinary_system2.44168767
14MP0002938_white_spotting2.43901127
15MP0002234_abnormal_pharynx_morphology2.41377569
16MP0009379_abnormal_foot_pigmentation2.26538318
17* MP0002098_abnormal_vibrissa_morphology2.23405737
18* MP0009250_abnormal_appendicular_skeleto2.23181551
19* MP0000049_abnormal_middle_ear2.07414736
20MP0010678_abnormal_skin_adnexa2.00696276
21MP0004381_abnormal_hair_follicle1.95811085
22* MP0000534_abnormal_ureter_morphology1.95368849
23MP0001346_abnormal_lacrimal_gland1.92253693
24MP0000678_abnormal_parathyroid_gland1.85214582
25MP0002653_abnormal_ependyma_morphology1.83870468
26MP0005503_abnormal_tendon_morphology1.82670944
27* MP0002249_abnormal_larynx_morphology1.78648961
28MP0005076_abnormal_cell_differentiation1.75727850
29MP0005423_abnormal_somatic_nervous1.75607043
30MP0000647_abnormal_sebaceous_gland1.74696354
31MP0004272_abnormal_basement_membrane1.74111422
32* MP0003937_abnormal_limbs/digits/tail_de1.70630287
33MP0000467_abnormal_esophagus_morphology1.70591745
34MP0002282_abnormal_trachea_morphology1.70278352
35MP0000516_abnormal_urinary_system1.69699467
36MP0005367_renal/urinary_system_phenotyp1.69699467
37MP0003880_abnormal_central_pattern1.67642664
38MP0004084_abnormal_cardiac_muscle1.59418971
39* MP0002932_abnormal_joint_morphology1.59376663
40MP0001529_abnormal_vocalization1.57386578
41MP0003315_abnormal_perineum_morphology1.55365531
42* MP0002233_abnormal_nose_morphology1.50501439
43MP0001485_abnormal_pinna_reflex1.47804736
44* MP0002116_abnormal_craniofacial_bone1.45993239
45MP0003705_abnormal_hypodermis_morpholog1.44499473
46* MP0003755_abnormal_palate_morphology1.40399969
47* MP0003935_abnormal_craniofacial_develop1.39780984
48MP0005451_abnormal_body_composition1.37162802
49MP0003938_abnormal_ear_development1.35721179
50MP0004264_abnormal_extraembryonic_tissu1.35207325
51MP0008789_abnormal_olfactory_epithelium1.34332350
52MP0002751_abnormal_autonomic_nervous1.29887056
53* MP0002109_abnormal_limb_morphology1.28454077
54MP0003121_genomic_imprinting1.26552807
55MP0002184_abnormal_innervation1.26538249
56* MP0003861_abnormal_nervous_system1.26241252
57MP0000613_abnormal_salivary_gland1.25303073
58MP0003115_abnormal_respiratory_system1.25208240
59MP0005171_absent_coat_pigmentation1.24642188
60* MP0000432_abnormal_head_morphology1.23473807
61MP0002796_impaired_skin_barrier1.23186538
62MP0002736_abnormal_nociception_after1.20972060
63MP0009384_cardiac_valve_regurgitation1.20887661
64MP0009672_abnormal_birth_weight1.19057465
65MP0004133_heterotaxia1.18976325
66MP0005248_abnormal_Harderian_gland1.18032469
67* MP0001286_abnormal_eye_development1.16876758
68* MP0001293_anophthalmia1.16475103
69MP0002177_abnormal_outer_ear1.16270941
70* MP0000163_abnormal_cartilage_morphology1.15905373
71* MP0000026_abnormal_inner_ear1.15606493
72MP0005623_abnormal_meninges_morphology1.15351696
73MP0005499_abnormal_olfactory_system1.15271799
74MP0005394_taste/olfaction_phenotype1.15271799
75* MP0000428_abnormal_craniofacial_morphol1.14653716
76MP0010234_abnormal_vibrissa_follicle1.14620288
77* MP0002092_abnormal_eye_morphology1.14377143
78MP0003890_abnormal_embryonic-extraembry1.13863197
79MP0003693_abnormal_embryo_hatching1.13762377
80* MP0000377_abnormal_hair_follicle1.13286110
81MP0004134_abnormal_chest_morphology1.12981857
82MP0005646_abnormal_pituitary_gland1.12424764
83MP0003119_abnormal_digestive_system1.12084385
84MP0003136_yellow_coat_color1.08914514
85MP0002277_abnormal_respiratory_mucosa1.06235584
86MP0000955_abnormal_spinal_cord1.05812694
87* MP0002085_abnormal_embryonic_tissue1.05335690
88MP0005275_abnormal_skin_tensile1.04096193
89MP0003567_abnormal_fetal_cardiomyocyte1.03787420
90* MP0005508_abnormal_skeleton_morphology1.03653963
91* MP0002697_abnormal_eye_size1.02367556
92MP0002060_abnormal_skin_morphology1.02113388
93MP0002102_abnormal_ear_morphology0.99999317
94* MP0002115_abnormal_skeleton_extremities0.97134455
95* MP0002111_abnormal_tail_morphology0.95604232
96MP0003787_abnormal_imprinting0.95305824
97MP0006292_abnormal_olfactory_placode0.94560143
98MP0004742_abnormal_vestibular_system0.94275191
99MP0002254_reproductive_system_inflammat0.93990809
100MP0001299_abnormal_eye_distance/0.93944864
101* MP0002152_abnormal_brain_morphology0.92918342
102MP0000538_abnormal_urinary_bladder0.91426691
103MP0001216_abnormal_epidermal_layer0.91280950
104* MP0002113_abnormal_skeleton_development0.90735209
105MP0000462_abnormal_digestive_system0.90540382
106MP0001968_abnormal_touch/_nociception0.90101691
107MP0002127_abnormal_cardiovascular_syste0.88764444
108MP0002909_abnormal_adrenal_gland0.88486340
109* MP0001340_abnormal_eyelid_morphology0.87819424
110MP0008932_abnormal_embryonic_tissue0.87037745
111MP0000733_abnormal_muscle_development0.85357189
112MP0009703_decreased_birth_body0.85270405
113MP0003123_paternal_imprinting0.85226706
114MP0003453_abnormal_keratinocyte_physiol0.85111569
115MP0000427_abnormal_hair_cycle0.84816017
116MP0005220_abnormal_exocrine_pancreas0.83564175
117MP0010094_abnormal_chromosome_stability0.83180835
118MP0002972_abnormal_cardiac_muscle0.81225009
119* MP0002084_abnormal_developmental_patter0.80529193
120* MP0002114_abnormal_axial_skeleton0.79021689
121* MP0005391_vision/eye_phenotype0.78835690
122MP0001270_distended_abdomen0.78559561
123MP0002089_abnormal_postnatal_growth/wei0.77639385
124MP0010771_integument_phenotype0.76836175
125MP0000778_abnormal_nervous_system0.76190243
126MP0002752_abnormal_somatic_nervous0.75926665
127MP0001963_abnormal_hearing_physiology0.74275454
128MP0002822_catalepsy0.73786792
129* MP0002081_perinatal_lethality0.73627617
130MP0000631_abnormal_neuroendocrine_gland0.73240046
131MP0003077_abnormal_cell_cycle0.73172962
132MP0004036_abnormal_muscle_relaxation0.72208805
133MP0004957_abnormal_blastocyst_morpholog0.71051389
134MP0001849_ear_inflammation0.70974641
135MP0000767_abnormal_smooth_muscle0.70356738
136MP0004885_abnormal_endolymph0.69126692
137MP0005501_abnormal_skin_physiology0.68819193
138MP0003828_pulmonary_edema0.68659171
139MP0003936_abnormal_reproductive_system0.68593967
140MP0003283_abnormal_digestive_organ0.68084520

Predicted human phenotypes

RankGene SetZ-score
1Aplasia cutis congenita (HP:0001057)3.54688154
2Onycholysis (HP:0001806)3.49273980
3Milia (HP:0001056)3.44837019
4Abnormality of the parietal bone (HP:0002696)3.38904974
5Septate vagina (HP:0001153)3.25665636
6Short middle phalanx of the 5th finger (HP:0004220)3.15034651
7Microglossia (HP:0000171)3.03587461
8Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.90530877
9Midline defect of the nose (HP:0004122)2.90243424
10Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.87689365
11Reticulocytopenia (HP:0001896)2.86105108
12Absent eyebrow (HP:0002223)2.84848112
13Absent eyelashes (HP:0000561)2.79629034
14Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.79397591
15Renal duplication (HP:0000075)2.79279363
16Hyperacusis (HP:0010780)2.78378745
17Abnormality of the phalanges of the 5th finger (HP:0004213)2.77757244
18Micronodular cirrhosis (HP:0001413)2.73827607
19Abnormality of the phalanges of the 2nd finger (HP:0009541)2.72341482
20Hypotrichosis (HP:0001006)2.71662057
21Morphological abnormality of the middle ear (HP:0008609)2.71069772
22Amelogenesis imperfecta (HP:0000705)2.69425868
23J-shaped sella turcica (HP:0002680)2.69389750
24Follicular hyperkeratosis (HP:0007502)2.65040655
25Atrophic scars (HP:0001075)2.63389337
26Absent frontal sinuses (HP:0002688)2.62524487
27Aplasia/Hypoplasia of the sacrum (HP:0008517)2.59239164
28Abnormality of the nasolacrimal system (HP:0000614)2.58094331
29Abnormality of cochlea (HP:0000375)2.54581435
30Overriding aorta (HP:0002623)2.54258656
31Ridged nail (HP:0001807)2.51501709
32Abnormality of the lacrimal duct (HP:0011481)2.51391252
33Partial duplication of thumb phalanx (HP:0009944)2.51055466
34Cutaneous finger syndactyly (HP:0010554)2.49493346
35Epiphyseal dysplasia (HP:0002656)2.49311518
36Preauricular pit (HP:0004467)2.48863225
37Periauricular skin pits (HP:0100277)2.48863225
38Fragile nails (HP:0001808)2.47351493
39High anterior hairline (HP:0009890)2.44947887
40Oligodactyly (HP:0012165)2.44626846
41Parakeratosis (HP:0001036)2.42915514
42Pterygium (HP:0001059)2.42771240
43Concave nail (HP:0001598)2.41369805
44Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.40531378
45Short 4th metacarpal (HP:0010044)2.40531378
46Asymmetry of the thorax (HP:0001555)2.39610648
47Anophthalmia (HP:0000528)2.39499294
48Renal dysplasia (HP:0000110)2.38342190
49Down-sloping shoulders (HP:0200021)2.38077317
50Septo-optic dysplasia (HP:0100842)2.37994130
51Maternal diabetes (HP:0009800)2.33379708
52Broad distal phalanx of finger (HP:0009836)2.31981289
53Woolly hair (HP:0002224)2.30369978
54Morphological abnormality of the inner ear (HP:0011390)2.30140939
55Aplasia of the musculature (HP:0100854)2.29781205
56Cutaneous syndactyly (HP:0012725)2.28653865
57Unilateral renal agenesis (HP:0000122)2.28399724
58Abnormality of the diencephalon (HP:0010662)2.27731691
59Chromosomal breakage induced by crosslinking agents (HP:0003221)2.27385764
60Vitreoretinal degeneration (HP:0000655)2.27108841
61Bifid tongue (HP:0010297)2.25802487
62Split foot (HP:0001839)2.25793964
63Broad toe (HP:0001837)2.24686832
64Abnormality of the middle phalanges of the toes (HP:0010183)2.23565742
65Deformed sella turcica (HP:0002681)2.23537378
66Plantar hyperkeratosis (HP:0007556)2.22568940
67Enlarged penis (HP:0000040)2.20800193
68Recurrent corneal erosions (HP:0000495)2.19492958
69Duplication of thumb phalanx (HP:0009942)2.19294507
70Abnormality of the aortic arch (HP:0012303)2.17224240
71Bilateral microphthalmos (HP:0007633)2.16958368
72Absent septum pellucidum (HP:0001331)2.16255122
73Double outlet right ventricle (HP:0001719)2.15118257
74Congenital malformation of the right heart (HP:0011723)2.15118257
75Pulmonary artery stenosis (HP:0004415)2.14487684
76Triphalangeal thumb (HP:0001199)2.14091668
77Abnormality of incisor morphology (HP:0011063)2.12141412
78Skin pits (HP:0100276)2.11415495
79Patellar aplasia (HP:0006443)2.11206362
80Abnormality of cells of the erythroid lineage (HP:0012130)2.07923627
81Nasolacrimal duct obstruction (HP:0000579)2.05983175
82Elfin facies (HP:0004428)2.05667051
83Abnormality of the septum pellucidum (HP:0007375)2.05652893
84Oligodactyly (hands) (HP:0001180)2.03952545
85Esophageal atresia (HP:0002032)2.02702190
86Bicornuate uterus (HP:0000813)2.02631321
87Hypoplastic left heart (HP:0004383)2.01936475
88Abnormal pancreas size (HP:0012094)2.01376097
89Myelomeningocele (HP:0002475)1.99642339
90Mesomelia (HP:0003027)1.96743945
91Aplasia/Hypoplasia of the patella (HP:0006498)1.95635151
92Short middle phalanx of finger (HP:0005819)1.95598240
93Chromsome breakage (HP:0040012)1.94214879
94Abnormality of the incisor (HP:0000676)1.94009980
95Hypoplastic labia majora (HP:0000059)1.93799326
96Abnormality of the 2nd finger (HP:0004100)1.93639455
97Short 5th finger (HP:0009237)1.93440803
98Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.92946059
99Abnormal number of incisors (HP:0011064)1.91917200
100Abnormal number of erythroid precursors (HP:0012131)1.90948326
101Coronal craniosynostosis (HP:0004440)1.90766965
102Sprengel anomaly (HP:0000912)1.90472890
103Delayed epiphyseal ossification (HP:0002663)1.90214888
104Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.89965576
105Increased nuchal translucency (HP:0010880)1.89857835
106Lip pit (HP:0100267)1.89252019
107Esophageal varix (HP:0002040)1.89063676
108Alopecia of scalp (HP:0002293)1.88804649
109Natal tooth (HP:0000695)1.88558130
110Missing ribs (HP:0000921)1.88323597
111Abnormality of the frontal sinuses (HP:0002687)1.86544195
112Abdominal distention (HP:0003270)1.85800829
113Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.85671182
114White forelock (HP:0002211)1.84927016
115Keratoconus (HP:0000563)1.84018463
116Increased corneal curvature (HP:0100692)1.84018463
117Rib fusion (HP:0000902)1.83782504
118Right ventricular cardiomyopathy (HP:0011663)1.82707349
119Ectopic kidney (HP:0000086)1.80910774
120Ulnar claw (HP:0001178)1.79889743
121Hemivertebrae (HP:0002937)1.79837362
122Abnormality of the right ventricle (HP:0001707)1.77623679
123Abnormality of the labia majora (HP:0012881)1.76754643
124Abnormality of the pubic bones (HP:0003172)1.76672455
125Bifid scrotum (HP:0000048)1.76533982
126Corneal erosion (HP:0200020)1.75591283
127Aplasia involving bones of the upper limbs (HP:0009823)1.74458166
128Aplasia of the phalanges of the hand (HP:0009802)1.74458166
129Aplasia involving bones of the extremities (HP:0009825)1.74458166
130Renovascular hypertension (HP:0100817)1.74289575
131Abnormality of the distal phalanx of the thumb (HP:0009617)1.73946191
132Congenital sensorineural hearing impairment (HP:0008527)1.73932415
133Abnormality of the renal collecting system (HP:0004742)1.73154196
134Abnormality of the carotid arteries (HP:0005344)1.72977855
135Abnormal ventriculo-arterial connection (HP:0011563)1.71924615
136Transposition of the great arteries (HP:0001669)1.71924615
137Abnormal connection of the cardiac segments (HP:0011545)1.71924615
138Preaxial foot polydactyly (HP:0001841)1.71296701
139Absent hair (HP:0002298)1.71046102
140Renal hypoplasia (HP:0000089)1.70898790
141Advanced eruption of teeth (HP:0006288)1.70622391
142Partial duplication of the phalanx of hand (HP:0009999)1.69556283
143True hermaphroditism (HP:0010459)1.69480770
144Abnormality of the sella turcica (HP:0002679)1.69329823
145Insomnia (HP:0100785)1.69057054
146Synostosis involving the elbow (HP:0003938)1.69019466
147Humeroradial synostosis (HP:0003041)1.69019466
148Patellar dislocation (HP:0002999)1.68705778
149Optic nerve hypoplasia (HP:0000609)1.68527804
150Hypoplastic heart (HP:0001961)1.68364873
151Aplasia involving forearm bones (HP:0009822)1.68158449
152Absent forearm bone (HP:0003953)1.68158449
153Myokymia (HP:0002411)1.66920041
154Buphthalmos (HP:0000557)1.66248140
155Germ cell neoplasia (HP:0100728)1.65350781
156Abnormality of the phalanges of the hallux (HP:0010057)1.64624021
157Hypoplastic pelvis (HP:0008839)1.64069799
158Abnormality of the 4th metacarpal (HP:0010012)1.63293539
159Vertebral hypoplasia (HP:0008417)1.62254780
160Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.62254780
161Macroorchidism (HP:0000053)1.60589435
162Bell-shaped thorax (HP:0001591)1.59498961
163Atresia of the external auditory canal (HP:0000413)1.56990083
164Tracheal stenosis (HP:0002777)1.56711027
165Preaxial hand polydactyly (HP:0001177)1.56147416
166Hypoplastic ischia (HP:0003175)1.55291447
167Exostoses (HP:0100777)1.54455833
168Bronchomalacia (HP:0002780)1.54016805
169Megalencephaly (HP:0001355)1.53083251
170Absent radius (HP:0003974)1.52394371
171Coarctation of aorta (HP:0001680)1.52253849
172Arnold-Chiari malformation (HP:0002308)1.52009861
173Choanal stenosis (HP:0000452)1.51229815

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.30300478
2SIK35.23623061
3EPHB24.97201266
4PKN23.51082570
5STK38L3.12853139
6LATS13.02722980
7MUSK2.92129806
8OBSCN2.85675053
9MAP3K102.70139544
10BCR2.64462723
11STK392.63974220
12SIK12.46305853
13PBK2.44535342
14WNK42.39104498
15SMG12.34861800
16ZAK2.13708821
17PNCK2.11364679
18VRK21.95296099
19STK241.93262352
20MYLK1.74990138
21BMPR1B1.72998263
22PRPF4B1.71242963
23CDK81.66185442
24CASK1.63576148
25OXSR11.55272570
26MST41.53550109
27WEE11.49726766
28ERBB21.48006715
29EEF2K1.45956025
30NTRK21.40409014
31DMPK1.39178568
32CAMK2B1.37013170
33MKNK11.35544418
34DDR21.34202505
35SCYL21.34026053
36CLK11.27099669
37TRPM71.26046042
38TAF11.25829188
39YES11.24522199
40EPHA41.21975209
41CDC71.21180498
42TNIK1.16339220
43CAMK2D1.15734280
44ERBB31.12779470
45CAMK2G1.12698226
46NEK61.12692895
47ROCK11.07518544
48PRKD31.05762665
49KSR11.05190003
50STK31.04781449
51TAOK21.04377844
52WNK11.02944622
53AKT30.99349348
54FGFR10.97918637
55MKNK20.97345070
56NME20.96718743
57MARK30.96161227
58ROCK20.95951137
59TSSK60.95905104
60LRRK20.94442953
61NUAK10.93999552
62FER0.92937512
63TYRO30.88012521
64PIK3CA0.87297419
65MET0.87117813
66CDK30.86926783
67BUB10.85190183
68NME10.81282339
69TRIM280.79871645
70MAP2K10.79831745
71RPS6KB10.78419324
72MTOR0.76978192
73NLK0.76388312
74MAPK150.74717357
75TGFBR10.74309961
76AURKB0.67740958
77TESK10.67057919
78CHEK20.67012938
79ILK0.66272320
80ADRBK20.66240201
81BRSK10.65638358
82CDC42BPA0.65490347
83TTK0.64370480
84IRAK20.60501460
85MAP2K20.60332425
86MARK10.59807990
87ATR0.59707620
88EIF2AK30.59408720
89FGFR20.58923356
90RPS6KA40.58431614
91CHUK0.58155362
92AURKA0.58000863
93MAP3K90.57317878
94MAP3K30.57125767
95PKN10.56929108
96DYRK20.56610667
97PASK0.56488144
98VRK10.55565150
99CDK90.55170033
100TXK0.53880366
101RET0.53448726
102MINK10.53374112
103NEK10.53236549
104PRKCE0.52829897
105MELK0.51878605
106CDK70.51013700
107TTN0.50345136
108PTK60.49810881
109PRKCI0.49153884
110RPS6KB20.48506666
111PAK40.47579957
112MAPKAPK20.47124656
113CSNK1A1L0.46757829
114STK160.44730847
115EPHA20.44616772
116MAPKAPK30.44445211
117WNK30.44380036
118RPS6KA20.44103065
119ICK0.44041447
120CAMK10.43856320
121CAMK40.43535792
122BRD40.43435985
123SGK4940.43431693
124SGK2230.43431693
125BCKDK0.42820303
126DYRK1A0.42495740
127DYRK1B0.41659651
128PAK20.41170596
129PDGFRA0.41153987
130PRKCZ0.40936521
131LATS20.40338997
132PRKG10.40185409
133EIF2AK20.39687207
134LMTK20.39686984
135AKT20.38986854
136SRPK10.38745229
137PLK10.38714471
138STK100.37443224
139NTRK30.37112770
140IRAK10.36848603
141RPS6KA10.36744316
142UHMK10.35952831
143RPS6KC10.35304919
144RPS6KL10.35304919
145CSNK1E0.35094960
146BTK0.35019298
147CDK10.34844506
148CSNK1A10.34511115
149MAPK70.34493175
150PTK20.34339066
151LIMK10.33352934
152RPS6KA60.32758616
153MAPK30.32456382
154IRAK30.31716268
155CHEK10.31577491
156EPHA30.30679686
157AKT10.29757343
158SGK20.27800920
159TGFBR20.27127866
160ADRBK10.26775815

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052175.13341277
2Hedgehog signaling pathway_Homo sapiens_hsa043403.76454071
3Protein digestion and absorption_Homo sapiens_hsa049743.44467833
4Ribosome_Homo sapiens_hsa030103.39215062
5ECM-receptor interaction_Homo sapiens_hsa045122.79001111
6* Hippo signaling pathway_Homo sapiens_hsa043902.69093170
7Notch signaling pathway_Homo sapiens_hsa043302.38897017
8Wnt signaling pathway_Homo sapiens_hsa043102.13129776
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.97921446
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.93737072
11Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.90882239
12Axon guidance_Homo sapiens_hsa043601.88837516
13Pancreatic secretion_Homo sapiens_hsa049721.86822885
14Vitamin B6 metabolism_Homo sapiens_hsa007501.69044308
15DNA replication_Homo sapiens_hsa030301.61484877
16Thyroid hormone signaling pathway_Homo sapiens_hsa049191.57156708
17Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.54726754
18Dilated cardiomyopathy_Homo sapiens_hsa054141.53144362
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.51802366
20Tight junction_Homo sapiens_hsa045301.50992673
21Adherens junction_Homo sapiens_hsa045201.50485800
22Thyroid cancer_Homo sapiens_hsa052161.47520686
23Pathways in cancer_Homo sapiens_hsa052001.46206754
24Small cell lung cancer_Homo sapiens_hsa052221.45503929
25* TGF-beta signaling pathway_Homo sapiens_hsa043501.43393735
26Melanogenesis_Homo sapiens_hsa049161.43111798
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.43106388
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.41064581
29Proteoglycans in cancer_Homo sapiens_hsa052051.41057727
30Focal adhesion_Homo sapiens_hsa045101.36798020
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.35005583
32Cardiac muscle contraction_Homo sapiens_hsa042601.34634018
33Prostate cancer_Homo sapiens_hsa052151.34565957
34Oxidative phosphorylation_Homo sapiens_hsa001901.27700158
35Protein export_Homo sapiens_hsa030601.25112958
36MicroRNAs in cancer_Homo sapiens_hsa052061.24683899
37Endometrial cancer_Homo sapiens_hsa052131.22432213
38Sulfur relay system_Homo sapiens_hsa041221.21605398
39Longevity regulating pathway - mammal_Homo sapiens_hsa042111.16020975
40RNA transport_Homo sapiens_hsa030131.15962169
41Base excision repair_Homo sapiens_hsa034101.15131479
42Arachidonic acid metabolism_Homo sapiens_hsa005901.14833820
43Melanoma_Homo sapiens_hsa052181.14452402
44mRNA surveillance pathway_Homo sapiens_hsa030151.13933269
45PI3K-Akt signaling pathway_Homo sapiens_hsa041511.13575790
46Parkinsons disease_Homo sapiens_hsa050121.12522996
47Huntingtons disease_Homo sapiens_hsa050161.10701914
48HTLV-I infection_Homo sapiens_hsa051661.10434042
49Sphingolipid metabolism_Homo sapiens_hsa006001.08888613
50Mismatch repair_Homo sapiens_hsa034301.07491117
51Mineral absorption_Homo sapiens_hsa049781.05107662
52Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.04316693
53Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.02671328
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02383792
55* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01203007
56Central carbon metabolism in cancer_Homo sapiens_hsa052301.01202343
57AMPK signaling pathway_Homo sapiens_hsa041521.00601515
58Asthma_Homo sapiens_hsa053100.98506702
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.97985004
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95920338
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95023336
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93239329
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92333452
64Biosynthesis of amino acids_Homo sapiens_hsa012300.89801337
65Steroid biosynthesis_Homo sapiens_hsa001000.88768566
66Estrogen signaling pathway_Homo sapiens_hsa049150.88687985
67Nucleotide excision repair_Homo sapiens_hsa034200.87676316
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.87490314
69Vibrio cholerae infection_Homo sapiens_hsa051100.87375484
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87144081
71Renin-angiotensin system_Homo sapiens_hsa046140.87093089
72Autoimmune thyroid disease_Homo sapiens_hsa053200.86677089
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85671009
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.85334424
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.85214742
76Glioma_Homo sapiens_hsa052140.83308211
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81450668
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80955355
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79288405
80Circadian entrainment_Homo sapiens_hsa047130.79258097
81Viral myocarditis_Homo sapiens_hsa054160.78875727
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78434362
83RNA polymerase_Homo sapiens_hsa030200.76273104
84Allograft rejection_Homo sapiens_hsa053300.74896875
852-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74412933
86Thyroid hormone synthesis_Homo sapiens_hsa049180.73903271
87Proteasome_Homo sapiens_hsa030500.73474718
88Fatty acid elongation_Homo sapiens_hsa000620.73424480
89Ether lipid metabolism_Homo sapiens_hsa005650.72692212
90Dopaminergic synapse_Homo sapiens_hsa047280.70819407
91Non-small cell lung cancer_Homo sapiens_hsa052230.70721042
92Alzheimers disease_Homo sapiens_hsa050100.70660091
93Cocaine addiction_Homo sapiens_hsa050300.70333972
94Amoebiasis_Homo sapiens_hsa051460.69979270
95Colorectal cancer_Homo sapiens_hsa052100.68887186
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68614156
97Pentose phosphate pathway_Homo sapiens_hsa000300.68488511
98Graft-versus-host disease_Homo sapiens_hsa053320.67235174
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67224384
100mTOR signaling pathway_Homo sapiens_hsa041500.65198708
101Butanoate metabolism_Homo sapiens_hsa006500.65078010
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64936273
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64758620
104VEGF signaling pathway_Homo sapiens_hsa043700.64686579
105Choline metabolism in cancer_Homo sapiens_hsa052310.64520419
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62541221
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62418532
108Glutamatergic synapse_Homo sapiens_hsa047240.61211441
109Toxoplasmosis_Homo sapiens_hsa051450.60969816
110One carbon pool by folate_Homo sapiens_hsa006700.60451221
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60287631
112Linoleic acid metabolism_Homo sapiens_hsa005910.59781504
113Rap1 signaling pathway_Homo sapiens_hsa040150.57712691
114Gap junction_Homo sapiens_hsa045400.57316712
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56724871
116Folate biosynthesis_Homo sapiens_hsa007900.56669389
117Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.54051803
118Inositol phosphate metabolism_Homo sapiens_hsa005620.54036675
119Lysine degradation_Homo sapiens_hsa003100.53507234
120Herpes simplex infection_Homo sapiens_hsa051680.53299541
121Alcoholism_Homo sapiens_hsa050340.52984080
122Insulin signaling pathway_Homo sapiens_hsa049100.52155844
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51349962
124Bladder cancer_Homo sapiens_hsa052190.50831220
125Vitamin digestion and absorption_Homo sapiens_hsa049770.50693402
126Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50588472
127Pancreatic cancer_Homo sapiens_hsa052120.50387839
128Gastric acid secretion_Homo sapiens_hsa049710.50000711
129Measles_Homo sapiens_hsa051620.49904676
130Amphetamine addiction_Homo sapiens_hsa050310.49807249
131Cholinergic synapse_Homo sapiens_hsa047250.49752830
132Influenza A_Homo sapiens_hsa051640.49554208
133Fanconi anemia pathway_Homo sapiens_hsa034600.49187166
134Basal transcription factors_Homo sapiens_hsa030220.48836703
135Cell cycle_Homo sapiens_hsa041100.48533328
136Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47638487
137Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46249908
138Insulin secretion_Homo sapiens_hsa049110.45226881
139cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44753447
140Cysteine and methionine metabolism_Homo sapiens_hsa002700.44428798
141Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43080127
142Jak-STAT signaling pathway_Homo sapiens_hsa046300.42394578
143Homologous recombination_Homo sapiens_hsa034400.42360657
144Pyrimidine metabolism_Homo sapiens_hsa002400.42216514
145Hematopoietic cell lineage_Homo sapiens_hsa046400.40908692
146Cyanoamino acid metabolism_Homo sapiens_hsa004600.40765831
147TNF signaling pathway_Homo sapiens_hsa046680.40143384
148Hepatitis B_Homo sapiens_hsa051610.39713457
149Chronic myeloid leukemia_Homo sapiens_hsa052200.38686233
150ErbB signaling pathway_Homo sapiens_hsa040120.38367873
151Rheumatoid arthritis_Homo sapiens_hsa053230.37497157
152Ras signaling pathway_Homo sapiens_hsa040140.36084341
153N-Glycan biosynthesis_Homo sapiens_hsa005100.34354664
154Spliceosome_Homo sapiens_hsa030400.33890960
155Hepatitis C_Homo sapiens_hsa051600.33874420
156Circadian rhythm_Homo sapiens_hsa047100.33197306
157Malaria_Homo sapiens_hsa051440.33182128
158Legionellosis_Homo sapiens_hsa051340.33160574
159Renal cell carcinoma_Homo sapiens_hsa052110.32072238
160NF-kappa B signaling pathway_Homo sapiens_hsa040640.30998628
161RNA degradation_Homo sapiens_hsa030180.30881399
162Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30158947

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