BMPER

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted protein that interacts with, and inhibits bone morphogenetic protein (BMP) function. It has been shown to inhibit BMP2- and BMP4-dependent osteoblast differentiation and BMP-dependent differentiation of the chondrogenic cells. Mutations in this gene are associated with a lethal skeletal disorder, diaphanospondylodysostosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)6.29923900
2extracellular fibril organization (GO:0043206)6.08163457
3collagen fibril organization (GO:0030199)5.85072705
4dermatan sulfate biosynthetic process (GO:0030208)5.57072767
5bone trabecula formation (GO:0060346)5.55655516
6chondrocyte proliferation (GO:0035988)5.32003876
7pericardium development (GO:0060039)5.27691568
8fibril organization (GO:0097435)5.16219774
9peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)5.08237355
10sequestering of extracellular ligand from receptor (GO:0035581)5.07082489
11dermatan sulfate metabolic process (GO:0030205)5.04127566
12endocardial cushion development (GO:0003197)4.90538815
13regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901214.53252432
14extracellular matrix assembly (GO:0085029)4.51142173
15positive regulation of cardiac muscle cell differentiation (GO:2000727)4.35288572
16endodermal cell differentiation (GO:0035987)4.24551425
17regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.07751012
18negative regulation of hormone biosynthetic process (GO:0032353)4.06115858
19regulation of cardiac muscle cell differentiation (GO:2000725)4.05468014
20retina vasculature morphogenesis in camera-type eye (GO:0061299)4.03016333
21peptidyl-proline hydroxylation (GO:0019511)3.96012895
22regulation of axon extension involved in axon guidance (GO:0048841)3.90856592
23respiratory tube development (GO:0030323)3.88021976
24craniofacial suture morphogenesis (GO:0097094)3.86631017
25negative regulation of chondrocyte differentiation (GO:0032331)3.80906581
26neuron projection extension involved in neuron projection guidance (GO:1902284)3.78737571
27axon extension involved in axon guidance (GO:0048846)3.78737571
28collagen metabolic process (GO:0032963)3.77250006
29negative regulation of axon extension involved in axon guidance (GO:0048843)3.76402530
30collagen catabolic process (GO:0030574)3.68801641
31basement membrane organization (GO:0071711)3.68675757
32positive regulation of cardiac muscle tissue development (GO:0055025)3.61540802
33regulation of axon guidance (GO:1902667)3.58275449
34multicellular organismal macromolecule metabolic process (GO:0044259)3.54571113
35negative regulation of hormone metabolic process (GO:0032351)3.46614207
36mesenchymal-epithelial cell signaling (GO:0060638)3.45203659
37regulation of tight junction assembly (GO:2000810)3.44071181
38cranial suture morphogenesis (GO:0060363)3.43872385
39negative regulation of cartilage development (GO:0061037)3.43379501
40vascular endothelial growth factor signaling pathway (GO:0038084)3.40836577
41extracellular matrix disassembly (GO:0022617)3.39451936
42negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.39084113
43positive regulation of osteoblast proliferation (GO:0033690)3.37847308
44regulation of glucocorticoid metabolic process (GO:0031943)3.37335915
45negative regulation of catenin import into nucleus (GO:0035414)3.36724697
46multicellular organismal catabolic process (GO:0044243)3.34384909
47skin morphogenesis (GO:0043589)3.34098986
48multicellular organismal metabolic process (GO:0044236)3.34065569
49chondrocyte development (GO:0002063)3.32894768
50negative regulation of axon guidance (GO:1902668)3.28677866
51protein hydroxylation (GO:0018126)3.26763946
52regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.23764219
53metanephric mesenchyme development (GO:0072075)3.23356222
54negative regulation of embryonic development (GO:0045992)3.22379725
55regulation of cardiac muscle tissue development (GO:0055024)3.20317133
56chondroitin sulfate biosynthetic process (GO:0030206)3.18011170
57mesenchymal cell differentiation involved in kidney development (GO:0072161)3.17645597
58mesenchymal cell differentiation involved in renal system development (GO:2001012)3.17645597
59negative regulation of activin receptor signaling pathway (GO:0032926)3.17312673
60glomerular basement membrane development (GO:0032836)3.16003045
61insulin-like growth factor receptor signaling pathway (GO:0048009)3.13589782
62cell migration involved in heart development (GO:0060973)3.13296311
63protein localization to cell surface (GO:0034394)3.12223844
64polarized epithelial cell differentiation (GO:0030859)3.11765145
65negative regulation of cardiac muscle tissue development (GO:0055026)3.09845338
66negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.08840852
67positive regulation of cardiac muscle cell proliferation (GO:0060045)3.08783933
68presynaptic membrane organization (GO:0097090)3.08040240
69regulation of transforming growth factor beta2 production (GO:0032909)3.07501984
70tooth mineralization (GO:0034505)3.07309181
71cell adhesion mediated by integrin (GO:0033627)3.06218414
72chondroitin sulfate catabolic process (GO:0030207)3.05144308
73organ formation (GO:0048645)3.04695646
74outflow tract septum morphogenesis (GO:0003148)3.04598841
75wound healing, spreading of epidermal cells (GO:0035313)3.03607652
76venous blood vessel morphogenesis (GO:0048845)3.01456211
77negative regulation of stem cell proliferation (GO:2000647)3.01034636
78cell migration involved in sprouting angiogenesis (GO:0002042)3.00054689
79kidney mesenchyme development (GO:0072074)2.97926517
80extracellular matrix organization (GO:0030198)2.97489710
81extracellular structure organization (GO:0043062)2.95936431
82extracellular negative regulation of signal transduction (GO:1900116)2.95702079
83extracellular regulation of signal transduction (GO:1900115)2.95702079
84cartilage morphogenesis (GO:0060536)2.95213862
85positive regulation of fatty acid oxidation (GO:0046321)2.93233569
86cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.92916781
87* negative regulation of BMP signaling pathway (GO:0030514)2.92562171
88locomotory exploration behavior (GO:0035641)2.89184792
89regulation of chondrocyte differentiation (GO:0032330)2.88491164
90cardiac myofibril assembly (GO:0055003)2.87592780
91regulation of mesoderm development (GO:2000380)2.85222767
92positive regulation of astrocyte differentiation (GO:0048711)2.84923942
93blood vessel maturation (GO:0001955)2.84826068
94uterus development (GO:0060065)2.84263017
95regulation of cartilage development (GO:0061035)2.83066040
96atrioventricular valve morphogenesis (GO:0003181)2.82438887
97positive regulation of cardiac muscle tissue growth (GO:0055023)2.82280933
98cellular response to fluid shear stress (GO:0071498)2.79705703
99substrate adhesion-dependent cell spreading (GO:0034446)2.79650600
100lung vasculature development (GO:0060426)2.78394174
101regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.77710983
102organ induction (GO:0001759)2.77708290
103type B pancreatic cell proliferation (GO:0044342)2.77676972
104hippo signaling (GO:0035329)2.75686958
105positive regulation of epithelial to mesenchymal transition (GO:0010718)2.74915187
106positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.74857409
107anterior/posterior axis specification, embryo (GO:0008595)2.74318006
108endoderm formation (GO:0001706)2.74047227
109neural crest cell development (GO:0014032)2.73608733
110protein retention in ER lumen (GO:0006621)2.71617932
111apoptotic cell clearance (GO:0043277)2.71579898
112smooth muscle tissue development (GO:0048745)2.71299796
113primitive streak formation (GO:0090009)2.70735343
114positive regulation of glycogen biosynthetic process (GO:0045725)2.70510707
115regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.70261243
116* regulation of pathway-restricted SMAD protein phosphorylation (GO:0060393)2.69813965
117planar cell polarity pathway involved in neural tube closure (GO:0090179)2.69797248
118regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.66792269
119regulation of plasminogen activation (GO:0010755)2.65967527
120trabecula formation (GO:0060343)2.65617049
121positive regulation of stem cell differentiation (GO:2000738)2.65240116
122negative chemotaxis (GO:0050919)2.64121338
123maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.63906413
124epithelial cell-cell adhesion (GO:0090136)2.63176338
125positive regulation of protein autophosphorylation (GO:0031954)2.63068151
126outer ear morphogenesis (GO:0042473)2.63006531
127synaptic vesicle docking involved in exocytosis (GO:0016081)2.62773944
128regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.62691906
129response to follicle-stimulating hormone (GO:0032354)2.61171532
130positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.60762450
131plasma membrane repair (GO:0001778)2.60153723
132positive regulation of endothelial cell apoptotic process (GO:2000353)2.60114774
133epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.58405523
134mesenchymal cell differentiation (GO:0048762)2.58381931
135cardiac epithelial to mesenchymal transition (GO:0060317)2.57790861
136myelination in peripheral nervous system (GO:0022011)2.57505676
137peripheral nervous system axon ensheathment (GO:0032292)2.57505676
138positive regulation of synapse assembly (GO:0051965)2.57265544
139embryonic foregut morphogenesis (GO:0048617)2.57208030
140embryonic cranial skeleton morphogenesis (GO:0048701)2.57151867
141response to redox state (GO:0051775)2.54642733
142cellular response to vitamin (GO:0071295)2.54608645
143lung morphogenesis (GO:0060425)2.54573168
144diaphragm development (GO:0060539)2.54293865
145atrial septum morphogenesis (GO:0060413)2.54211400
146mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.54201832
147mesenchyme development (GO:0060485)2.52402387
148keratan sulfate catabolic process (GO:0042340)2.51770744
149regulation of cardioblast differentiation (GO:0051890)2.50963593
150cardiac chamber formation (GO:0003207)2.50608000
151glomerulus development (GO:0032835)2.49674415
152cellular response to amino acid stimulus (GO:0071230)2.49576077
153epithelial to mesenchymal transition (GO:0001837)2.49474472
154skeletal muscle organ development (GO:0060538)2.49011223
155regulation of cardiac muscle cell proliferation (GO:0060043)2.48374686
156dorsal/ventral axis specification (GO:0009950)2.48367680
157embryonic viscerocranium morphogenesis (GO:0048703)2.47749054
158virion attachment to host cell (GO:0019062)2.46885812
159adhesion of symbiont to host cell (GO:0044650)2.46885812
160positive regulation of axon extension (GO:0045773)2.46650640
161cell migration involved in gastrulation (GO:0042074)2.46368186
162lymphangiogenesis (GO:0001946)2.45912341
163ventricular cardiac muscle cell development (GO:0055015)2.44629490
164cell proliferation involved in kidney development (GO:0072111)2.43853411
165SMAD protein complex assembly (GO:0007183)2.43436695
166positive regulation of heart growth (GO:0060421)2.43357834
167mesoderm formation (GO:0001707)2.42737347

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.11453186
2PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.32609503
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.12904143
4WT1_19549856_ChIP-ChIP_CCG9911_Human2.82117546
5* EED_16625203_ChIP-ChIP_MESCs_Mouse2.76535848
6CLOCK_20551151_ChIP-Seq_293T_Human2.74822919
7* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.57819330
8* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.54697433
9* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.49008640
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.47513956
11* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.47513956
12* EP300_21415370_ChIP-Seq_HL-1_Mouse2.47389379
13* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.37786035
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37736511
15* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.36765373
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35894764
17* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.26496672
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.25195629
19* CJUN_26792858_Chip-Seq_BT549_Human2.19748465
20* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.16772635
21PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.09202611
22JARID2_20075857_ChIP-Seq_MESCs_Mouse2.06612171
23* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.01233929
24* NRF2_20460467_ChIP-Seq_MEFs_Mouse2.00149375
25* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.00149375
26GBX2_23144817_ChIP-Seq_PC3_Human1.98521128
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.97586989
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.95219710
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92271464
30* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.91249465
31AR_21572438_ChIP-Seq_LNCaP_Human1.89939042
32* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.89177316
33TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.87718745
34* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.85763118
35HIF1A_21447827_ChIP-Seq_MCF-7_Human1.85122658
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.82974915
37* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.77664674
38EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.74307758
39* TP53_20018659_ChIP-ChIP_R1E_Mouse1.73399279
40* BRD4_25478319_ChIP-Seq_HGPS_Human1.70054680
41* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.69823253
42SMAD3_21741376_ChIP-Seq_HESCs_Human1.68514151
43CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.67430273
44EZH2_22144423_ChIP-Seq_EOC_Human1.64818462
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63937293
46RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.63568861
47* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58140760
48* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56017661
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.53951405
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.51590692
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51360200
52* TP53_18474530_ChIP-ChIP_U2OS_Human1.47450196
53* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.41739134
54* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41630780
55* PIAS1_25552417_ChIP-Seq_VCAP_Human1.40135729
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.36039765
57* ISL1_27105846_Chip-Seq_CPCs_Mouse1.34647544
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34527728
59TP53_16413492_ChIP-PET_HCT116_Human1.31549524
60HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.30761106
61* SMAD4_21741376_ChIP-Seq_HESCs_Human1.30661382
62* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.30493371
63TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.30079104
64TAF15_26573619_Chip-Seq_HEK293_Human1.29511930
65TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29172457
66LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28170533
67* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25517834
68TP63_17297297_ChIP-ChIP_HaCaT_Human1.24879041
69* STAT3_23295773_ChIP-Seq_U87_Human1.24291007
70NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.23817036
71NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.22972741
72* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22634433
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22266214
74CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.21924031
75EWS_26573619_Chip-Seq_HEK293_Human1.21600957
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.21138244
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20826703
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19005019
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18708179
80PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16232021
81RING1B_27294783_Chip-Seq_ESCs_Mouse1.15958599
82EZH2_27294783_Chip-Seq_ESCs_Mouse1.15906953
83KDM2B_26808549_Chip-Seq_REH_Human1.15814262
84POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14264863
85* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13326440
86* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13204826
87RNF2_27304074_Chip-Seq_NSC_Mouse1.12255795
88* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11885359
89ESR2_21235772_ChIP-Seq_MCF-7_Human1.11445568
90* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11391864
91CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11050666
92* AR_25329375_ChIP-Seq_VCAP_Human1.10872774
93* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10636573
94* BCAT_22108803_ChIP-Seq_LS180_Human1.10427446
95SOX9_26525672_Chip-Seq_HEART_Mouse1.10045675
96CBX2_27304074_Chip-Seq_ESCs_Mouse1.09987596
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09699075
98ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09659631
99YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09622006
100* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08155376
101ESR1_21235772_ChIP-Seq_MCF-7_Human1.08002696
102CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07824708
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.07661215
104* TCF4_23295773_ChIP-Seq_U87_Human1.06842002
105TBX3_20139965_ChIP-Seq_MESCs_Mouse1.06193489
106TBX3_20139965_ChIP-Seq_ESCs_Mouse1.05587479
107AR_21909140_ChIP-Seq_LNCAP_Human1.05383319
108TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05005857
109* SMAD4_21741376_ChIP-Seq_EPCs_Human1.04783462
110FUS_26573619_Chip-Seq_HEK293_Human1.04708777
111AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03759166
112* SMAD4_21799915_ChIP-Seq_A2780_Human1.03135003
113ARNT_22903824_ChIP-Seq_MCF-7_Human1.02803582
114EOMES_21245162_ChIP-Seq_HESCs_Human1.02667878
115* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02543315
116BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02331731
117SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02126538
118* TCF4_22108803_ChIP-Seq_LS180_Human1.00627771
119MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.00246600
120RING1B_27294783_Chip-Seq_NPCs_Mouse0.99732713
121* P300_19829295_ChIP-Seq_ESCs_Human0.98342567
122* SOX2_21211035_ChIP-Seq_LN229_Gbm0.97099146
123DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95781405
124ZNF274_21170338_ChIP-Seq_K562_Hela0.94901594
125SMAD3_21741376_ChIP-Seq_EPCs_Human0.94893074
126* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94680819
127NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92893874
128SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92644248
129SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.91288086
130SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.91288086
131AHR_22903824_ChIP-Seq_MCF-7_Human0.90865816
132VDR_22108803_ChIP-Seq_LS180_Human0.90792086
133JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89144248
134* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.88925428
135ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.88722585
136SOX2_20726797_ChIP-Seq_SW620_Human0.88519647
137AR_19668381_ChIP-Seq_PC3_Human0.87633097

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen8.46455515
2MP0005503_abnormal_tendon_morphology5.80834473
3MP0005275_abnormal_skin_tensile5.37109743
4MP0004272_abnormal_basement_membrane3.92542157
5MP0003705_abnormal_hypodermis_morpholog3.80115557
6MP0005623_abnormal_meninges_morphology3.19756506
7MP0003279_aneurysm3.18618017
8MP0001958_emphysema2.92309295
9MP0009384_cardiac_valve_regurgitation2.66768558
10MP0003890_abnormal_embryonic-extraembry2.53989296
11MP0005257_abnormal_intraocular_pressure2.31286809
12* MP0005508_abnormal_skeleton_morphology2.19899187
13MP0002108_abnormal_muscle_morphology2.11873324
14* MP0009250_abnormal_appendicular_skeleto1.99464956
15MP0003385_abnormal_body_wall1.84776377
16MP0006054_spinal_hemorrhage1.84663040
17MP0003942_abnormal_urinary_system1.75397277
18* MP0003115_abnormal_respiratory_system1.73275882
19MP0004858_abnormal_nervous_system1.72029113
20MP0002060_abnormal_skin_morphology1.70897679
21MP0000534_abnormal_ureter_morphology1.67719633
22MP0003122_maternal_imprinting1.63346792
23MP0000751_myopathy1.60588062
24MP0002102_abnormal_ear_morphology1.52119243
25MP0002295_abnormal_pulmonary_circulatio1.49392101
26MP0010030_abnormal_orbit_morphology1.46560196
27MP0000537_abnormal_urethra_morphology1.45951714
28MP0004859_abnormal_synaptic_plasticity1.43971257
29MP0009053_abnormal_anal_canal1.39989563
30MP0003566_abnormal_cell_adhesion1.36732639
31MP0000013_abnormal_adipose_tissue1.36604127
32MP0001542_abnormal_bone_strength1.36130265
33MP0005023_abnormal_wound_healing1.33927569
34MP0002896_abnormal_bone_mineralization1.31953501
35MP0010368_abnormal_lymphatic_system1.31842112
36MP0003950_abnormal_plasma_membrane1.30709863
37MP0002932_abnormal_joint_morphology1.27153919
38MP0000462_abnormal_digestive_system1.26958569
39MP0001243_abnormal_dermal_layer1.26563342
40MP0001299_abnormal_eye_distance/1.24910050
41* MP0002282_abnormal_trachea_morphology1.22442522
42MP0000516_abnormal_urinary_system1.21595878
43MP0005367_renal/urinary_system_phenotyp1.21595878
44MP0004084_abnormal_cardiac_muscle1.18468775
45* MP0000163_abnormal_cartilage_morphology1.17379194
46* MP0002697_abnormal_eye_size1.13616747
47MP0003091_abnormal_cell_migration1.13087048
48MP0001177_atelectasis1.13058557
49MP0000428_abnormal_craniofacial_morphol1.09544511
50MP0003755_abnormal_palate_morphology1.08260845
51MP0003119_abnormal_digestive_system1.08036685
52MP0004134_abnormal_chest_morphology1.07518883
53MP0010352_gastrointestinal_tract_polyps1.07216015
54MP0004510_myositis1.06600846
55MP0002127_abnormal_cardiovascular_syste1.06080756
56* MP0002115_abnormal_skeleton_extremities1.04294047
57MP0000767_abnormal_smooth_muscle1.04096774
58MP0002736_abnormal_nociception_after1.03229410
59* MP0005390_skeleton_phenotype1.02270864
60MP0000003_abnormal_adipose_tissue1.01781886
61MP0000733_abnormal_muscle_development0.99710431
62MP0003937_abnormal_limbs/digits/tail_de0.98561680
63* MP0000049_abnormal_middle_ear0.95640746
64MP0004215_abnormal_myocardial_fiber0.95465375
65MP0001348_abnormal_lacrimal_gland0.95424697
66MP0003941_abnormal_skin_development0.95084408
67MP0006138_congestive_heart_failure0.94940597
68MP0000749_muscle_degeneration0.94297710
69MP0004233_abnormal_muscle_weight0.93413767
70MP0009780_abnormal_chondrocyte_physiolo0.92484631
71MP0003283_abnormal_digestive_organ0.90567029
72MP0002168_other_aberrant_phenotype0.89796960
73MP0002933_joint_inflammation0.88800046
74* MP0002113_abnormal_skeleton_development0.87861545
75* MP0002249_abnormal_larynx_morphology0.87274525
76* MP0002109_abnormal_limb_morphology0.86532894
77MP0002089_abnormal_postnatal_growth/wei0.86466780
78MP0005388_respiratory_system_phenotype0.84911078
79MP0002133_abnormal_respiratory_system0.84911078
80MP0003880_abnormal_central_pattern0.84424143
81* MP0001175_abnormal_lung_morphology0.83964234
82MP0001879_abnormal_lymphatic_vessel0.83407160
83MP0003123_paternal_imprinting0.82858830
84MP0005084_abnormal_gallbladder_morpholo0.81812464
85MP0005620_abnormal_muscle_contractility0.81747164
86MP0005171_absent_coat_pigmentation0.81592882
87MP0002084_abnormal_developmental_patter0.81325035
88MP0005595_abnormal_vascular_smooth0.80797974
89MP0005197_abnormal_uvea_morphology0.80635618
90MP0005193_abnormal_anterior_eye0.79634351
91MP0002735_abnormal_chemical_nociception0.79563208
92MP0004085_abnormal_heartbeat0.78309846
93* MP0002116_abnormal_craniofacial_bone0.77376165
94* MP0003935_abnormal_craniofacial_develop0.77368300
95MP0000759_abnormal_skeletal_muscle0.76825841
96MP0001968_abnormal_touch/_nociception0.76226155
97MP0002128_abnormal_blood_circulation0.75802662
98MP0003567_abnormal_fetal_cardiomyocyte0.75528961
99MP0005369_muscle_phenotype0.73756457
100* MP0002111_abnormal_tail_morphology0.73501110
101MP0002233_abnormal_nose_morphology0.73318036
102MP0004087_abnormal_muscle_fiber0.73180195
103MP0004036_abnormal_muscle_relaxation0.73050438
104MP0000432_abnormal_head_morphology0.70510493
105MP0003045_fibrosis0.70116829
106* MP0002114_abnormal_axial_skeleton0.69282386
107MP0004484_altered_response_of0.68497046
108MP0008775_abnormal_heart_ventricle0.67274908
109MP0000762_abnormal_tongue_morphology0.66842882
110MP0000639_abnormal_adrenal_gland0.64976050
111MP0002998_abnormal_bone_remodeling0.64471078
112MP0004885_abnormal_endolymph0.64106755
113MP0000750_abnormal_muscle_regeneration0.63943785
114MP0000538_abnormal_urinary_bladder0.63840298
115MP0001614_abnormal_blood_vessel0.63638407
116MP0005375_adipose_tissue_phenotype0.62901065
117MP0000266_abnormal_heart_morphology0.62379222
118MP0000778_abnormal_nervous_system0.62260108
119MP0001915_intracranial_hemorrhage0.62139519
120MP0004145_abnormal_muscle_electrophysio0.61673105
121MP0005164_abnormal_response_to0.60746070
122MP0001544_abnormal_cardiovascular_syste0.59636625
123MP0005385_cardiovascular_system_phenoty0.59636625
124MP0001661_extended_life_span0.59335890
125MP0002925_abnormal_cardiovascular_devel0.59227563
126MP0002177_abnormal_outer_ear0.58771583
127MP0010386_abnormal_urinary_bladder0.58372373
128MP0002938_white_spotting0.58136147

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)8.93720220
2Premature rupture of membranes (HP:0001788)6.83574947
3Shallow orbits (HP:0000586)4.93918358
4Ankle contracture (HP:0006466)4.75302648
5Broad metatarsal (HP:0001783)4.73292306
6Aortic dissection (HP:0002647)4.45583387
7Soft skin (HP:0000977)4.37201034
8Cervical subluxation (HP:0003308)4.32029961
9Wrist flexion contracture (HP:0001239)4.12978698
10Cerebral aneurysm (HP:0004944)4.10241177
11Vertebral compression fractures (HP:0002953)4.00461366
12Aortic aneurysm (HP:0004942)3.78802000
13Dilatation of the ascending aorta (HP:0005111)3.67455326
14Abnormality of dentin (HP:0010299)3.67394462
15Bladder diverticulum (HP:0000015)3.63843112
16Peritonitis (HP:0002586)3.44382725
17Type 1 muscle fiber predominance (HP:0003803)3.43384452
18Follicular hyperkeratosis (HP:0007502)3.38526756
19Spinal rigidity (HP:0003306)3.35329624
20Atrophic scars (HP:0001075)3.20980092
21Biconcave vertebral bodies (HP:0004586)3.20775019
22Neonatal short-limb short stature (HP:0008921)3.16720636
23Wormian bones (HP:0002645)3.14500465
24Abnormality of the fetal cardiovascular system (HP:0010948)3.10895940
25Abnormal umbilical cord blood vessels (HP:0011403)3.10895940
26Single umbilical artery (HP:0001195)3.10895940
27Mitral valve prolapse (HP:0001634)3.06734187
28Increased variability in muscle fiber diameter (HP:0003557)3.06131118
29Fragile skin (HP:0001030)3.01620094
30Blue sclerae (HP:0000592)2.99867200
31Overgrowth (HP:0001548)2.95358210
32Camptodactyly of toe (HP:0001836)2.86582527
33Genu recurvatum (HP:0002816)2.84676769
34Hyperextensible skin (HP:0000974)2.84627502
35Nuclear cataract (HP:0100018)2.78686006
36Pulmonary artery stenosis (HP:0004415)2.67193295
37Back pain (HP:0003418)2.66938456
38Vascular tortuosity (HP:0004948)2.66218081
39Zonular cataract (HP:0010920)2.63729506
40Abnormality of skeletal muscle fiber size (HP:0012084)2.63444165
41Slender build (HP:0001533)2.58688885
42Bowel diverticulosis (HP:0005222)2.58629700
43Round ear (HP:0100830)2.57864842
44Keratoconus (HP:0000563)2.56693487
45Increased corneal curvature (HP:0100692)2.56693487
46Wide anterior fontanel (HP:0000260)2.54640938
47Increased connective tissue (HP:0009025)2.54447722
48Vitreoretinal degeneration (HP:0000655)2.48891800
49Arterial tortuosity (HP:0005116)2.48068448
50Spondylolisthesis (HP:0003302)2.44282944
51Broad ribs (HP:0000885)2.39907560
52Infantile muscular hypotonia (HP:0008947)2.37524283
53Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.33382611
54Aneurysm (HP:0002617)2.31414070
55Abnormality of the acetabulum (HP:0003170)2.30804908
56Narrow nasal bridge (HP:0000446)2.30802672
57Coronal craniosynostosis (HP:0004440)2.26204794
58Ectopia lentis (HP:0001083)2.24698547
59Aortic regurgitation (HP:0001659)2.24362644
60Joint laxity (HP:0001388)2.22677267
61Abnormal delivery (HP:0001787)2.22135053
62Abnormality of the umbilical cord (HP:0010881)2.21572844
63Mild short stature (HP:0003502)2.20210755
64Elbow flexion contracture (HP:0002987)2.20086596
65Abnormality of the ischium (HP:0003174)2.19938353
66Aortic valve stenosis (HP:0001650)2.17384819
67Spinal cord lesions (HP:0100561)2.16815777
68Syringomyelia (HP:0003396)2.16815777
69Osteopenia (HP:0000938)2.16070507
70Mitral stenosis (HP:0001718)2.14688206
71Joint contractures involving the joints of the feet (HP:0100492)2.13040068
72Flexion contracture of toe (HP:0005830)2.13040068
73Hypoplasia of the iris (HP:0007676)2.10142169
74Pulmonic stenosis (HP:0001642)2.09083433
75Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.08859967
76Thin bony cortex (HP:0002753)2.06598703
77Hip contracture (HP:0003273)2.06169988
78Mildly elevated creatine phosphokinase (HP:0008180)2.06075942
79Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.05840011
80Scapular winging (HP:0003691)2.02938246
81Abnormality of the phalanges of the 2nd finger (HP:0009541)2.01530022
82Short middle phalanx of the 5th finger (HP:0004220)2.00112584
83Bifid tongue (HP:0010297)1.99458390
84Osteoarthritis (HP:0002758)1.97236070
85Preaxial foot polydactyly (HP:0001841)1.97149061
86Cardiovascular calcification (HP:0011915)1.96304635
87Chorioretinal atrophy (HP:0000533)1.94815991
88Tarsal synostosis (HP:0008368)1.93276217
89Broad long bones (HP:0005622)1.91922102
90Coxa vara (HP:0002812)1.91389090
91Absent frontal sinuses (HP:0002688)1.90083075
92Knee flexion contracture (HP:0006380)1.89662822
93Striae distensae (HP:0001065)1.88747974
94Delayed closure of the anterior fontanelle (HP:0001476)1.88226187
95Corneal dystrophy (HP:0001131)1.87985595
96Delayed gross motor development (HP:0002194)1.87955078
97Decreased skull ossification (HP:0004331)1.87761988
98Microglossia (HP:0000171)1.87094335
99Abnormality of the phalanges of the 5th finger (HP:0004213)1.86787930
100Buphthalmos (HP:0000557)1.83914173
101Asymmetry of the thorax (HP:0001555)1.82936301
102Mesomelia (HP:0003027)1.80845459
103Deviation of the hallux (HP:0010051)1.80460669
104Limited hip movement (HP:0008800)1.80007669
105Synostosis involving bones of the feet (HP:0009140)1.79499102
106Synostosis involving bones of the lower limbs (HP:0009138)1.79499102
107Femoral bowing (HP:0002980)1.78949658
108Nonimmune hydrops fetalis (HP:0001790)1.78771160
109* Inguinal hernia (HP:0000023)1.78754289
110Abnormality of the middle phalanges of the toes (HP:0010183)1.78748909
111Protruding ear (HP:0000411)1.77248397
112Aplasia/Hypoplasia of the tibia (HP:0005772)1.75689655
113Limb-girdle muscle weakness (HP:0003325)1.75220571
114Morphological abnormality of the middle ear (HP:0008609)1.74703819
115Lymphangioma (HP:0100764)1.74384370
116Short nail (HP:0001799)1.72960007
117Mitral regurgitation (HP:0001653)1.72140960
118Hallux valgus (HP:0001822)1.70996073
119Abnormality of the anterior chamber (HP:0000593)1.70273886
120Breech presentation (HP:0001623)1.69463179
121Hypoventilation (HP:0002791)1.69249378
122Renal duplication (HP:0000075)1.69082880
123Venous abnormality (HP:0002624)1.68839048
124Platyspondyly (HP:0000926)1.68395737
125Ovoid vertebral bodies (HP:0003300)1.68096166
126Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.67382416
127Short 4th metacarpal (HP:0010044)1.67382416
128Delayed cranial suture closure (HP:0000270)1.67157508
129Abnormality of skull ossification (HP:0002703)1.67090378
130Venous insufficiency (HP:0005293)1.65914147
131Disproportionate tall stature (HP:0001519)1.65559733
132Hypoplastic left heart (HP:0004383)1.64252365
133Absent speech (HP:0001344)1.63166528
134Short hallux (HP:0010109)1.63036315
135Joint stiffness (HP:0001387)1.61201265
136Redundant skin (HP:0001582)1.61057733
137Flat cornea (HP:0007720)1.60178079
138Hydroxyprolinuria (HP:0003080)1.58615681
139Abnormality of proline metabolism (HP:0010907)1.58615681
140Increased number of teeth (HP:0011069)1.58169159

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS25.53451401
2DDR24.52774947
3PLK43.93984021
4ACVR1B3.69462494
5FLT33.03421158
6PDGFRA2.99996546
7TTN2.79030882
8LATS12.72998619
9BMPR1B2.68943284
10EPHB22.47213240
11FER2.42055348
12TRIB32.19903001
13PRKD32.00411386
14PLK21.99517332
15TNIK1.98151202
16PTK2B1.92252233
17MYLK1.90847506
18SIK11.88316578
19CASK1.87137011
20PAK31.86720630
21ERBB41.79301460
22DMPK1.72540391
23STK38L1.64855201
24ERBB31.57779175
25EPHA31.52117230
26FGFR11.48857653
27STK381.48263448
28LMTK21.47259303
29BMX1.39903601
30PIK3CA1.39635452
31NTRK31.37816197
32ROCK11.36656707
33PKN21.36624071
34PTK21.33942202
35PAK21.29201000
36STK101.21437628
37MET1.20757347
38LIMK11.20423964
39PNCK1.17671633
40RIPK11.15750780
41TIE11.10806290
42EPHA41.06887258
43NEK91.03814781
44KSR11.03538262
45PRKCE1.03507112
46MARK11.03286373
47MAP2K11.01296640
48SCYL21.00922100
49NUAK11.00653406
50FRK0.98520259
51ROCK20.97337854
52MELK0.94605204
53WEE10.93901550
54ADRBK10.92124551
55OBSCN0.91464015
56MAP3K60.86414421
57STK30.85207842
58PTK60.84985019
59MOS0.84620617
60CDK80.84261421
61PDGFRB0.84055655
62MAP2K70.83558206
63MAPK70.83360489
64PHKG20.83154872
65PHKG10.83154872
66ILK0.80965223
67ERN10.79940246
68PRKCH0.79912148
69DAPK30.78776661
70NTRK10.78700612
71MKNK10.76186482
72AKT30.75042688
73TESK10.74133061
74MKNK20.72475982
75MINK10.69974522
76TRPM70.69826639
77GRK70.69758871
78RET0.68401224
79NEK10.68342044
80EIF2AK10.66893408
81TRIM280.66667326
82LRRK20.66590296
83PDK40.65508703
84PDK30.65508703
85INSR0.62134415
86PRKD20.61406838
87MAP3K120.61304867
88BRAF0.58456907
89CDK140.57803935
90MAPK130.57531564
91DAPK20.56848583
92MTOR0.56847216
93MAP3K40.56103232
94FGFR20.56047686
95PLK30.55056239
96TGFBR20.54382499
97PRKD10.50292532
98SRC0.48681359
99PAK40.47512547
100CDK180.46790812
101MAP2K40.46705393
102CAMK2A0.46111848
103CDK150.46035105
104PAK10.45516901
105PINK10.45356865
106GRK10.44505148
107IGF1R0.44473289
108PRKG20.43506162
109GRK50.42280464
110WNK30.41967181
111CDC42BPA0.41815844
112BCR0.41458008
113MAP3K90.40824617
114PRKCZ0.40384243
115ARAF0.38875386
116CAMK2B0.38214435
117NEK20.37710406
118PRKCG0.37527927
119TGFBR10.37202929
120PRKAA20.36859945
121TEC0.36668479
122ABL20.35501892
123PAK60.34833371
124RPS6KA20.34111738
125INSRR0.32333498
126PDK20.32089871
127CDK11A0.31661421
128TAF10.30861273
129KIT0.30804262
130CAMK2G0.29856329
131ZAK0.29028634
132BRSK20.28910079
133SGK30.27826695
134GSK3A0.27634360
135CAMK10.27597318
136CAMK2D0.27187621
137RPS6KA40.27093514
138ADRBK20.27054194
139PIK3CG0.26969785
140BCKDK0.26966779
141BRD40.26048869
142MAP4K20.24796650
143EIF2AK20.24274543

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.45559208
2Focal adhesion_Homo sapiens_hsa045103.03388311
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.83096510
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.32050836
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.31043888
6Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.30876962
7Dilated cardiomyopathy_Homo sapiens_hsa054142.27979356
8Amoebiasis_Homo sapiens_hsa051462.18239101
9Protein digestion and absorption_Homo sapiens_hsa049742.16492222
10Proteoglycans in cancer_Homo sapiens_hsa052052.06016797
11TGF-beta signaling pathway_Homo sapiens_hsa043502.04373001
12Hippo signaling pathway_Homo sapiens_hsa043901.97715886
13Small cell lung cancer_Homo sapiens_hsa052221.93696131
14Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.89054278
15Bladder cancer_Homo sapiens_hsa052191.82213177
16Adherens junction_Homo sapiens_hsa045201.81206365
17Basal cell carcinoma_Homo sapiens_hsa052171.81041783
18AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.79376511
19Hedgehog signaling pathway_Homo sapiens_hsa043401.76531203
20Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.74369577
21PI3K-Akt signaling pathway_Homo sapiens_hsa041511.59234546
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.43133406
23Glutamatergic synapse_Homo sapiens_hsa047241.43014018
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.38442402
25Melanoma_Homo sapiens_hsa052181.31800607
26Axon guidance_Homo sapiens_hsa043601.29564428
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27958603
28Calcium signaling pathway_Homo sapiens_hsa040201.25632483
29Wnt signaling pathway_Homo sapiens_hsa043101.23120726
30Sulfur metabolism_Homo sapiens_hsa009201.22985338
31Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.22732295
32Gastric acid secretion_Homo sapiens_hsa049711.22551791
33Malaria_Homo sapiens_hsa051441.22323821
34Pathways in cancer_Homo sapiens_hsa052001.17817478
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12950033
36MicroRNAs in cancer_Homo sapiens_hsa052061.12548975
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.12021526
38Regulation of actin cytoskeleton_Homo sapiens_hsa048101.10649985
39Insulin secretion_Homo sapiens_hsa049111.10310624
40Melanogenesis_Homo sapiens_hsa049161.07405396
41Rap1 signaling pathway_Homo sapiens_hsa040150.99490412
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.97871254
43Gap junction_Homo sapiens_hsa045400.97807254
44Morphine addiction_Homo sapiens_hsa050320.97435139
45Central carbon metabolism in cancer_Homo sapiens_hsa052300.97105648
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95155975
47Prion diseases_Homo sapiens_hsa050200.95065755
48Tight junction_Homo sapiens_hsa045300.95046843
49Glioma_Homo sapiens_hsa052140.94693929
50Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94298048
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.90859576
52Salivary secretion_Homo sapiens_hsa049700.90454685
53PPAR signaling pathway_Homo sapiens_hsa033200.89603108
54Choline metabolism in cancer_Homo sapiens_hsa052310.89496601
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.89251411
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88823841
57Fatty acid metabolism_Homo sapiens_hsa012120.87318713
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87081421
59Vibrio cholerae infection_Homo sapiens_hsa051100.86772368
60Oxytocin signaling pathway_Homo sapiens_hsa049210.86435970
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.85109406
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83175926
63Estrogen signaling pathway_Homo sapiens_hsa049150.79879699
64ErbB signaling pathway_Homo sapiens_hsa040120.77981234
65GnRH signaling pathway_Homo sapiens_hsa049120.75753728
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75723422
67Viral myocarditis_Homo sapiens_hsa054160.74698191
68Nitrogen metabolism_Homo sapiens_hsa009100.74587068
69Phagosome_Homo sapiens_hsa041450.73880583
70Prostate cancer_Homo sapiens_hsa052150.73695747
71Long-term depression_Homo sapiens_hsa047300.72961613
72Sphingolipid metabolism_Homo sapiens_hsa006000.72397508
73Amphetamine addiction_Homo sapiens_hsa050310.72160508
74Endometrial cancer_Homo sapiens_hsa052130.70225057
75Insulin resistance_Homo sapiens_hsa049310.68173770
76Insulin signaling pathway_Homo sapiens_hsa049100.67544375
77Serotonergic synapse_Homo sapiens_hsa047260.67426793
78Renin secretion_Homo sapiens_hsa049240.67176606
79Thyroid hormone synthesis_Homo sapiens_hsa049180.66331237
80Glucagon signaling pathway_Homo sapiens_hsa049220.64789324
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.64422226
82Cocaine addiction_Homo sapiens_hsa050300.64339721
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62839541
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.60840107
85Fatty acid degradation_Homo sapiens_hsa000710.60083159
86Mineral absorption_Homo sapiens_hsa049780.59972522
87Chronic myeloid leukemia_Homo sapiens_hsa052200.59314080
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57831188
89Toxoplasmosis_Homo sapiens_hsa051450.57460587
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.57445813
91Cholinergic synapse_Homo sapiens_hsa047250.56970083
92Butanoate metabolism_Homo sapiens_hsa006500.56878443
93MAPK signaling pathway_Homo sapiens_hsa040100.56493815
94HIF-1 signaling pathway_Homo sapiens_hsa040660.56478225
95Circadian entrainment_Homo sapiens_hsa047130.56047866
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55688696
97Fatty acid biosynthesis_Homo sapiens_hsa000610.55395435
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.55200873
99Dopaminergic synapse_Homo sapiens_hsa047280.54975332
100Ras signaling pathway_Homo sapiens_hsa040140.54920895
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53789636
102Colorectal cancer_Homo sapiens_hsa052100.53734617
103Circadian rhythm_Homo sapiens_hsa047100.53168277
104AMPK signaling pathway_Homo sapiens_hsa041520.51132895
105Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50905132
106Renal cell carcinoma_Homo sapiens_hsa052110.49836119
107Ovarian steroidogenesis_Homo sapiens_hsa049130.49702707
108N-Glycan biosynthesis_Homo sapiens_hsa005100.48396602
109Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47576782
110Platelet activation_Homo sapiens_hsa046110.47378873
111Cardiac muscle contraction_Homo sapiens_hsa042600.47232695
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47028058
113GABAergic synapse_Homo sapiens_hsa047270.44480841
114Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44148631
115Lysine degradation_Homo sapiens_hsa003100.43842891
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.43815992
117Endocytosis_Homo sapiens_hsa041440.43281424
118Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42634822
119Taste transduction_Homo sapiens_hsa047420.42410555
120Synaptic vesicle cycle_Homo sapiens_hsa047210.41961497
121Oocyte meiosis_Homo sapiens_hsa041140.41589306
122Protein export_Homo sapiens_hsa030600.41331058
123cAMP signaling pathway_Homo sapiens_hsa040240.40799367
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40549495
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39954929
126Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39927452
127Glycerolipid metabolism_Homo sapiens_hsa005610.39511602
128Long-term potentiation_Homo sapiens_hsa047200.39383213
129Propanoate metabolism_Homo sapiens_hsa006400.39077561
130Shigellosis_Homo sapiens_hsa051310.39047927
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.39046777
132Nicotine addiction_Homo sapiens_hsa050330.38896019
133Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38756788
134Steroid biosynthesis_Homo sapiens_hsa001000.36830010
135Olfactory transduction_Homo sapiens_hsa047400.33677005
136Renin-angiotensin system_Homo sapiens_hsa046140.32792050

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