BMPR1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gene silencing by RNA (GO:0060966)4.17697077
2regulation of posttranscriptional gene silencing (GO:0060147)4.17697077
3regulation of gene silencing by miRNA (GO:0060964)4.17697077
4hippo signaling (GO:0035329)4.05488815
5paraxial mesoderm development (GO:0048339)3.95348031
6planar cell polarity pathway involved in neural tube closure (GO:0090179)3.52545351
7insulin-like growth factor receptor signaling pathway (GO:0048009)3.39185897
8regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.35011248
9endocardial cushion development (GO:0003197)3.34359585
10collagen fibril organization (GO:0030199)3.33927645
11polarized epithelial cell differentiation (GO:0030859)3.25709281
12G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.23497005
13chondrocyte proliferation (GO:0035988)3.14716935
14protein heterotrimerization (GO:0070208)3.06497176
15regulation of heart morphogenesis (GO:2000826)3.04869184
16negative regulation of chondrocyte differentiation (GO:0032331)3.04329747
17anterior/posterior axis specification, embryo (GO:0008595)3.04138050
18gastrulation with mouth forming second (GO:0001702)3.03716962
19plasma membrane repair (GO:0001778)2.98963693
20negative regulation of translation, ncRNA-mediated (GO:0040033)2.96810697
21regulation of translation, ncRNA-mediated (GO:0045974)2.96810697
22negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.96810697
23chondrocyte development (GO:0002063)2.94612649
24lateral sprouting from an epithelium (GO:0060601)2.94092176
25regulation of transforming growth factor beta2 production (GO:0032909)2.93032666
26bone trabecula formation (GO:0060346)2.92476932
27negative regulation of catenin import into nucleus (GO:0035414)2.91327789
28regulation of cardioblast differentiation (GO:0051890)2.90862607
29desmosome organization (GO:0002934)2.88786857
30hemidesmosome assembly (GO:0031581)2.86973004
31positive regulation of catenin import into nucleus (GO:0035413)2.86703275
32regulation of catenin import into nucleus (GO:0035412)2.86616961
33outer ear morphogenesis (GO:0042473)2.86265180
34presynaptic membrane assembly (GO:0097105)2.84405267
35craniofacial suture morphogenesis (GO:0097094)2.83726379
36chromatin remodeling at centromere (GO:0031055)2.83361785
37body morphogenesis (GO:0010171)2.80849242
38kidney morphogenesis (GO:0060993)2.79405187
39axon extension involved in axon guidance (GO:0048846)2.78170911
40neuron projection extension involved in neuron projection guidance (GO:1902284)2.78170911
41midgut development (GO:0007494)2.77355392
42notochord development (GO:0030903)2.75243849
43cell migration involved in sprouting angiogenesis (GO:0002042)2.71285056
44embryonic foregut morphogenesis (GO:0048617)2.71109894
45regulation of centriole replication (GO:0046599)2.71092369
46regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.70822195
47negative regulation of cartilage development (GO:0061037)2.67294273
48response to nitrosative stress (GO:0051409)2.65919487
49epithelial cell-cell adhesion (GO:0090136)2.65161967
50negative regulation of fatty acid transport (GO:2000192)2.64889783
51CENP-A containing nucleosome assembly (GO:0034080)2.62954140
52sequestering of extracellular ligand from receptor (GO:0035581)2.62602065
53regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.62193177
54positive regulation of glycogen biosynthetic process (GO:0045725)2.61713693
55positive regulation of hormone biosynthetic process (GO:0046886)2.59711222
56regulation of non-canonical Wnt signaling pathway (GO:2000050)2.59348103
57renal filtration (GO:0097205)2.58930197
58regulation of nuclear cell cycle DNA replication (GO:0033262)2.58374598
59positive regulation of fatty acid beta-oxidation (GO:0032000)2.58264673
60glomerular basement membrane development (GO:0032836)2.57942491
61regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.57849210
62non-canonical Wnt signaling pathway (GO:0035567)2.57825987
63Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.57085909
64cell fate commitment involved in formation of primary germ layer (GO:0060795)2.56299973
65regulation of cardioblast proliferation (GO:0003264)2.55112354
66regulation of secondary heart field cardioblast proliferation (GO:0003266)2.55112354
67* mesenchyme development (GO:0060485)2.53226397
68regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.52475766
69mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.51623346
70regulation of establishment of planar polarity (GO:0090175)2.50563387
71mesenchyme morphogenesis (GO:0072132)2.50060281
72somite development (GO:0061053)2.49994659
73establishment of apical/basal cell polarity (GO:0035089)2.49782346
74replication fork processing (GO:0031297)2.49776598
75negative regulation of DNA-dependent DNA replication (GO:2000104)2.49635341
76lung-associated mesenchyme development (GO:0060484)2.49533456
77cardiac myofibril assembly (GO:0055003)2.49013732
78* dorsal/ventral axis specification (GO:0009950)2.48843462
79Golgi transport vesicle coating (GO:0048200)2.48436739
80COPI coating of Golgi vesicle (GO:0048205)2.48436739
81cytoplasmic mRNA processing body assembly (GO:0033962)2.48200496
82presynaptic membrane organization (GO:0097090)2.48097095
83cochlea morphogenesis (GO:0090103)2.48033598
84camera-type eye morphogenesis (GO:0048593)2.47818443
85branching involved in prostate gland morphogenesis (GO:0060442)2.47726091
86regulation of hippo signaling (GO:0035330)2.47270577
87somatic hypermutation of immunoglobulin genes (GO:0016446)2.46899357
88somatic diversification of immune receptors via somatic mutation (GO:0002566)2.46899357
89organ induction (GO:0001759)2.46223887
90mesenchymal cell proliferation (GO:0010463)2.45862199
91prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.44946858
92heart morphogenesis (GO:0003007)2.44543853
93convergent extension (GO:0060026)2.44216175
94pre-miRNA processing (GO:0031054)2.43509870
95glucocorticoid receptor signaling pathway (GO:0042921)2.42871952
96artery development (GO:0060840)2.42409583
97metanephric mesenchyme development (GO:0072075)2.42135893
98embryonic retina morphogenesis in camera-type eye (GO:0060059)2.42099675
99cranial suture morphogenesis (GO:0060363)2.41534728
100cytoskeletal anchoring at plasma membrane (GO:0007016)2.41225027
101embryonic cranial skeleton morphogenesis (GO:0048701)2.40306623
102endocardial cushion morphogenesis (GO:0003203)2.39037883
103limb bud formation (GO:0060174)2.39003196
104mesenchymal-epithelial cell signaling (GO:0060638)2.38989720
105respiratory tube development (GO:0030323)2.38762663
106regulation of axon extension involved in axon guidance (GO:0048841)2.37299938
107glomerular filtration (GO:0003094)2.37107691
108embryonic body morphogenesis (GO:0010172)2.37050870
109endodermal cell differentiation (GO:0035987)2.36969696
110* positive regulation of mesenchymal cell proliferation (GO:0002053)2.36164059
111atrial cardiac muscle cell action potential (GO:0086014)2.35597979
112kidney mesenchyme development (GO:0072074)2.34318982
113DNA replication-dependent nucleosome organization (GO:0034723)2.33759000
114DNA replication-dependent nucleosome assembly (GO:0006335)2.33759000
115embryonic pattern specification (GO:0009880)2.33672317
116embryonic axis specification (GO:0000578)2.33439183
117* regulation of mesenchymal cell proliferation (GO:0010464)2.31926674
118regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.31595399
119regulation of mitotic spindle checkpoint (GO:1903504)2.31595399
120histone exchange (GO:0043486)2.31372043
121renal system development (GO:0072001)2.30511607
122inner ear receptor cell development (GO:0060119)2.30035291
123regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.29775085
124nonmotile primary cilium assembly (GO:0035058)2.29599018
125outflow tract septum morphogenesis (GO:0003148)2.29437677
126establishment of nucleus localization (GO:0040023)2.29042187
127branching involved in salivary gland morphogenesis (GO:0060445)2.28924314
128nodal signaling pathway (GO:0038092)2.28703757
129collecting duct development (GO:0072044)2.28702927
130somite rostral/caudal axis specification (GO:0032525)2.28251185
131negative regulation of embryonic development (GO:0045992)2.27469379
132lysine catabolic process (GO:0006554)2.27088950
133lysine metabolic process (GO:0006553)2.27088950
134establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.26557300
135regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.26444886
136* regulation of cell fate specification (GO:0042659)2.26394123
137DNA double-strand break processing (GO:0000729)2.25480649
138atrial septum morphogenesis (GO:0060413)2.24658937
139appendage development (GO:0048736)2.24182150
140limb development (GO:0060173)2.24182150
141nephron epithelium morphogenesis (GO:0072088)2.23639799
142nephron tubule morphogenesis (GO:0072078)2.23639799
143NLS-bearing protein import into nucleus (GO:0006607)2.23541474
144regulation of chondrocyte differentiation (GO:0032330)2.23510220
145regulation of centrosome duplication (GO:0010824)2.23479606
146regulation of gene silencing (GO:0060968)2.23174422
147regulation of centrosome cycle (GO:0046605)2.21707863
148adult heart development (GO:0007512)2.14754939
149DNA replication-independent nucleosome organization (GO:0034724)2.12324605
150DNA replication-independent nucleosome assembly (GO:0006336)2.12324605
151* regulation of mesoderm development (GO:2000380)2.12171734
152regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.08336554
153negative regulation of cytosolic calcium ion concentration (GO:0051481)2.06838809
154protein localization to kinetochore (GO:0034501)2.06077408
155establishment or maintenance of monopolar cell polarity (GO:0061339)2.05399426
156establishment of monopolar cell polarity (GO:0061162)2.05399426
157behavioral response to nicotine (GO:0035095)2.05315626
158* regulation of cell fate commitment (GO:0010453)2.02491905
159ncRNA catabolic process (GO:0034661)2.02465431
160maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.02222041
161cilium morphogenesis (GO:0060271)2.01315650
162establishment of planar polarity (GO:0001736)2.01185145
163establishment of tissue polarity (GO:0007164)2.01185145
164calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.01073705
165intraciliary transport (GO:0042073)1.99235721
166response to pheromone (GO:0019236)1.97828263
167reciprocal meiotic recombination (GO:0007131)1.97803124
168reciprocal DNA recombination (GO:0035825)1.97803124
169female gonad development (GO:0008585)1.96518776
170cell migration involved in gastrulation (GO:0042074)1.96455158
171cullin deneddylation (GO:0010388)1.96331406
172DNA replication checkpoint (GO:0000076)1.95652391
173otic vesicle formation (GO:0030916)1.94571263
174regulation of Wnt signaling pathway involved in heart development (GO:0003307)1.94266646
175mesenchymal cell differentiation (GO:0048762)1.93627557
176histone-serine phosphorylation (GO:0035404)1.93036662
177organ growth (GO:0035265)1.93011375
178DNA strand renaturation (GO:0000733)1.92471695
179olfactory bulb development (GO:0021772)1.92156307
180anterior/posterior axis specification (GO:0009948)1.92119711
181water-soluble vitamin biosynthetic process (GO:0042364)1.91530491
182postsynaptic membrane organization (GO:0001941)1.91245308

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.38976531
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.50854979
3GBX2_23144817_ChIP-Seq_PC3_Human2.96833374
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.91986084
5RBPJ_22232070_ChIP-Seq_NCS_Mouse2.69925740
6CLOCK_20551151_ChIP-Seq_293T_Human2.60552063
7FUS_26573619_Chip-Seq_HEK293_Human2.54285109
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.38356774
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.29595601
10EWS_26573619_Chip-Seq_HEK293_Human2.27029072
11IGF1R_20145208_ChIP-Seq_DFB_Human2.21248623
12TAF15_26573619_Chip-Seq_HEK293_Human2.13927413
13EP300_21415370_ChIP-Seq_HL-1_Mouse2.13208116
14P300_19829295_ChIP-Seq_ESCs_Human2.09420626
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.00641710
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.00344085
17WT1_19549856_ChIP-ChIP_CCG9911_Human1.99979144
18VDR_22108803_ChIP-Seq_LS180_Human1.98422835
19ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.96742894
20TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.96306716
21WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.94228270
22POU5F1_16153702_ChIP-ChIP_HESCs_Human1.93328560
23EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.90444764
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.89964504
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.87867957
26ZNF217_24962896_ChIP-Seq_MCF-7_Human1.85989359
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.85148357
28EZH2_22144423_ChIP-Seq_EOC_Human1.84934287
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84147372
30ESR1_20079471_ChIP-ChIP_T-47D_Human1.82420882
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82270001
32HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.78300719
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.76667345
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.76020479
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74451988
36ISL1_27105846_Chip-Seq_CPCs_Mouse1.74084571
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70809638
38ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.64144733
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.59580538
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56859582
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.56339439
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56271131
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.55910914
44SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.55861460
45SMAD4_21799915_ChIP-Seq_A2780_Human1.54871701
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54483139
47SALL4_18804426_ChIP-ChIP_XEN_Mouse1.54328121
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53772551
49CJUN_26792858_Chip-Seq_BT549_Human1.53094056
50AR_21909140_ChIP-Seq_LNCAP_Human1.52190728
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.50144857
52BRD4_25478319_ChIP-Seq_HGPS_Human1.48835231
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.48763036
54HIF1A_21447827_ChIP-Seq_MCF-7_Human1.48423414
55DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.48209344
56ZNF263_19887448_ChIP-Seq_K562_Human1.48202283
57FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.47540717
58E2F4_17652178_ChIP-ChIP_JURKAT_Human1.47497529
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46867492
60SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.44838244
61NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.44251911
62* STAT3_23295773_ChIP-Seq_U87_Human1.44097186
63FOXO3_23340844_ChIP-Seq_DLD1_Human1.44088279
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43875335
65CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.42524861
66E2F7_22180533_ChIP-Seq_HELA_Human1.42455470
67ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.42175297
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40752902
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.40578263
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40333588
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40083167
72* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.39989123
73PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.36350032
74SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.35540817
75KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.35249981
76TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.35204557
77SOX2_16153702_ChIP-ChIP_HESCs_Human1.34759105
78NANOG_16153702_ChIP-ChIP_HESCs_Human1.34148404
79TCF4_18268006_ChIP-ChIP_LS174T_Human1.33804306
80PPAR_26484153_Chip-Seq_NCI-H1993_Human1.33320980
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32571916
82IRF1_19129219_ChIP-ChIP_H3396_Human1.32531057
83TP53_16413492_ChIP-PET_HCT116_Human1.32329262
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31753768
85EZH2_18974828_ChIP-Seq_MESCs_Mouse1.29799164
86RNF2_18974828_ChIP-Seq_MESCs_Mouse1.29799164
87EED_16625203_ChIP-ChIP_MESCs_Mouse1.28237470
88RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27552005
89* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26267107
90* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26267107
91BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26052467
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25425773
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25425773
94ZFP281_18757296_ChIP-ChIP_E14_Mouse1.25392189
95ESR1_15608294_ChIP-ChIP_MCF-7_Human1.25384155
96* TCF4_23295773_ChIP-Seq_U87_Human1.25341459
97MYC_18940864_ChIP-ChIP_HL60_Human1.24473147
98PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24423375
99STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.23195326
100NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.22568991
101AHR_22903824_ChIP-Seq_MCF-7_Human1.22240817
102ZNF274_21170338_ChIP-Seq_K562_Hela1.21858952
103ELK1_19687146_ChIP-ChIP_HELA_Human1.21033234
104PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.20452064
105* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19623443
106IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19617423
107CBP_20019798_ChIP-Seq_JUKART_Human1.19617423
108MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19297225
109HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18834105
110RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18796517
111* RNF2_27304074_Chip-Seq_NSC_Mouse1.18587936
112SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.18363870
113ER_23166858_ChIP-Seq_MCF-7_Human1.17775519
114SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.17552703
115SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.17552703
116AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17190433
117RUNX2_22187159_ChIP-Seq_PCA_Human1.16756430
118TBX20_22080862_ChIP-Seq_HEART_Mouse1.16619117
119TBX20_22328084_ChIP-Seq_HEART_Mouse1.16619117
120* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16575378
121RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16443949
122WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15699013
123AR_25329375_ChIP-Seq_VCAP_Human1.15587026
124ARNT_22903824_ChIP-Seq_MCF-7_Human1.15254490
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14689377
126CBX2_27304074_Chip-Seq_ESCs_Mouse1.14312493
127EZH2_27294783_Chip-Seq_NPCs_Mouse1.13762957
128TP53_18474530_ChIP-ChIP_U2OS_Human1.13524674
129ZFP281_27345836_Chip-Seq_ESCs_Mouse1.13482123
130SOX9_26525672_Chip-Seq_HEART_Mouse1.11773689
131TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10855615
132TBX3_20139965_ChIP-Seq_MESCs_Mouse1.10851781
133TP53_20018659_ChIP-ChIP_R1E_Mouse1.10527725
134TBX3_20139965_ChIP-Seq_ESCs_Mouse1.10370514
135NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.10320143
136BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09602724
137TCF4_22108803_ChIP-Seq_LS180_Human1.09370494
138EZH2_27304074_Chip-Seq_ESCs_Mouse1.09298458
139KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08856828
140RING1B_27294783_Chip-Seq_NPCs_Mouse1.08622043
141STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08052508
142KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07984125
143E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07157733
144TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07119641
145TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07088525
146SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06660775
147TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06384813
148TCF3_18692474_ChIP-Seq_MEFs_Mouse1.05840816
149BCAT_22108803_ChIP-Seq_LS180_Human1.05761088
150PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04995583
151* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04741481
152CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.03719287
153FOXA2_19822575_ChIP-Seq_HepG2_Human1.03036183
154STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01636498
155NANOG_18555785_Chip-Seq_ESCs_Mouse1.01528000
156SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.01222724
157POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.00823034
158AR_21572438_ChIP-Seq_LNCaP_Human1.00542054
159EGR1_19374776_ChIP-ChIP_THP-1_Human0.99590773
160FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99525828
161ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99079226
162CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98822264
163SOX2_20726797_ChIP-Seq_SW620_Human0.98656048
164SMAD4_21741376_ChIP-Seq_EPCs_Human0.97843371
165* UBF1/2_26484160_Chip-Seq_HMECs_Human0.97746410
166EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97588282
167TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97577934
168SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97524656
169CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96628853
170LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96150801
171SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.95084265
172SOX2_21211035_ChIP-Seq_LN229_Gbm0.94272683
173FOXM1_23109430_ChIP-Seq_U2OS_Human0.93947137
174GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92789672
175FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92507845
176NFE2_27457419_Chip-Seq_LIVER_Mouse0.92354981

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.77963461
2MP0003705_abnormal_hypodermis_morpholog3.56333503
3MP0005275_abnormal_skin_tensile3.24564859
4MP0000537_abnormal_urethra_morphology3.20936743
5MP0005503_abnormal_tendon_morphology2.76675107
6MP0004272_abnormal_basement_membrane2.58911347
7MP0010030_abnormal_orbit_morphology2.55155414
8MP0009053_abnormal_anal_canal2.46687919
9MP0010234_abnormal_vibrissa_follicle2.43627644
10MP0005623_abnormal_meninges_morphology2.15976249
11MP0006292_abnormal_olfactory_placode2.10635294
12MP0003941_abnormal_skin_development1.99651877
13MP0003385_abnormal_body_wall1.94625554
14MP0004133_heterotaxia1.86201615
15MP0000534_abnormal_ureter_morphology1.85421586
16MP0003123_paternal_imprinting1.83685956
17MP0003942_abnormal_urinary_system1.82472300
18MP0009250_abnormal_appendicular_skeleto1.81074195
19MP0002102_abnormal_ear_morphology1.76480864
20MP0008057_abnormal_DNA_replication1.74053034
21MP0003136_yellow_coat_color1.73186513
22MP0005248_abnormal_Harderian_gland1.72158279
23* MP0001293_anophthalmia1.70398460
24MP0000516_abnormal_urinary_system1.67530152
25MP0005367_renal/urinary_system_phenotyp1.67530152
26MP0008877_abnormal_DNA_methylation1.67052701
27MP0002254_reproductive_system_inflammat1.61183472
28* MP0003937_abnormal_limbs/digits/tail_de1.60024687
29MP0000428_abnormal_craniofacial_morphol1.59328181
30MP0003122_maternal_imprinting1.56859985
31MP0009780_abnormal_chondrocyte_physiolo1.56035891
32MP0005187_abnormal_penis_morphology1.55542728
33MP0003283_abnormal_digestive_organ1.53094821
34MP0003115_abnormal_respiratory_system1.52502626
35MP0003755_abnormal_palate_morphology1.50101305
36MP0010352_gastrointestinal_tract_polyps1.44577474
37MP0000733_abnormal_muscle_development1.43674350
38* MP0009384_cardiac_valve_regurgitation1.40559945
39MP0002108_abnormal_muscle_morphology1.39414242
40MP0000762_abnormal_tongue_morphology1.38637969
41MP0002234_abnormal_pharynx_morphology1.37845446
42MP0003566_abnormal_cell_adhesion1.36891866
43* MP0003935_abnormal_craniofacial_develop1.36809796
44MP0005076_abnormal_cell_differentiation1.36504826
45MP0004084_abnormal_cardiac_muscle1.32392710
46* MP0002896_abnormal_bone_mineralization1.31956401
47MP0006054_spinal_hemorrhage1.31289313
48MP0004233_abnormal_muscle_weight1.30707599
49* MP0006072_abnormal_retinal_apoptosis1.30704490
50MP0001529_abnormal_vocalization1.30614092
51MP0002233_abnormal_nose_morphology1.29811022
52MP0002282_abnormal_trachea_morphology1.29709230
53MP0000778_abnormal_nervous_system1.29598793
54* MP0005508_abnormal_skeleton_morphology1.28443652
55MP0000569_abnormal_digit_pigmentation1.28348627
56MP0001958_emphysema1.28005463
57MP0003119_abnormal_digestive_system1.27823473
58MP0009697_abnormal_copulation1.27409125
59* MP0003567_abnormal_fetal_cardiomyocyte1.26554216
60MP0003718_maternal_effect1.25182154
61MP0004185_abnormal_adipocyte_glucose1.24842327
62* MP0001299_abnormal_eye_distance/1.24767009
63MP0010094_abnormal_chromosome_stability1.23951758
64MP0002060_abnormal_skin_morphology1.23014112
65MP0008932_abnormal_embryonic_tissue1.22111735
66MP0000751_myopathy1.19805960
67MP0002249_abnormal_larynx_morphology1.19463994
68MP0003693_abnormal_embryo_hatching1.18725482
69* MP0000432_abnormal_head_morphology1.18017750
70MP0003279_aneurysm1.17769592
71MP0004215_abnormal_myocardial_fiber1.16136123
72MP0002697_abnormal_eye_size1.15124135
73MP0003121_genomic_imprinting1.14980877
74MP0001984_abnormal_olfaction1.12150425
75MP0000049_abnormal_middle_ear1.09370290
76* MP0002932_abnormal_joint_morphology1.09206241
77* MP0000631_abnormal_neuroendocrine_gland1.08968123
78MP0000013_abnormal_adipose_tissue1.08953957
79MP0000003_abnormal_adipose_tissue1.08552824
80* MP0004197_abnormal_fetal_growth/weight/1.08202035
81MP0000566_synostosis1.07091384
82MP0000462_abnormal_digestive_system1.05750933
83MP0004957_abnormal_blastocyst_morpholog1.05597569
84MP0004087_abnormal_muscle_fiber1.04443554
85MP0001849_ear_inflammation1.03886829
86* MP0000163_abnormal_cartilage_morphology1.03769025
87* MP0002116_abnormal_craniofacial_bone1.01837810
88MP0008789_abnormal_olfactory_epithelium1.01574476
89* MP0003861_abnormal_nervous_system1.01003963
90MP0003195_calcinosis1.00344090
91MP0003890_abnormal_embryonic-extraembry1.00291633
92MP0009703_decreased_birth_body1.00079261
93* MP0010678_abnormal_skin_adnexa0.99832240
94MP0006138_congestive_heart_failure0.99325155
95MP0005551_abnormal_eye_electrophysiolog0.99168691
96MP0000647_abnormal_sebaceous_gland0.99138573
97* MP0002115_abnormal_skeleton_extremities0.98674612
98MP0005257_abnormal_intraocular_pressure0.98668077
99MP0002751_abnormal_autonomic_nervous0.98562508
100MP0003787_abnormal_imprinting0.98218184
101MP0002736_abnormal_nociception_after0.96912114
102* MP0002084_abnormal_developmental_patter0.96469829
103MP0008058_abnormal_DNA_repair0.95883649
104MP0003878_abnormal_ear_physiology0.95408626
105MP0005377_hearing/vestibular/ear_phenot0.95408626
106* MP0002109_abnormal_limb_morphology0.95104490
107MP0001485_abnormal_pinna_reflex0.94972143
108MP0001346_abnormal_lacrimal_gland0.94918022
109MP0010368_abnormal_lymphatic_system0.94156478
110* MP0002111_abnormal_tail_morphology0.94148223
111MP0010630_abnormal_cardiac_muscle0.92422370
112* MP0000427_abnormal_hair_cycle0.91591643
113MP0002098_abnormal_vibrissa_morphology0.91378971
114MP0005666_abnormal_adipose_tissue0.91338200
115MP0002837_dystrophic_cardiac_calcinosis0.91328236
116MP0000467_abnormal_esophagus_morphology0.91026480
117* MP0005253_abnormal_eye_physiology0.89212251
118MP0005171_absent_coat_pigmentation0.89105750
119MP0002938_white_spotting0.88866953
120MP0006276_abnormal_autonomic_nervous0.87389475
121MP0005375_adipose_tissue_phenotype0.87081281
122MP0003646_muscle_fatigue0.86829284
123MP0000750_abnormal_muscle_regeneration0.86069448
124MP0002653_abnormal_ependyma_morphology0.85487131
125MP0004145_abnormal_muscle_electrophysio0.85199897
126MP0003938_abnormal_ear_development0.85032067
127MP0002796_impaired_skin_barrier0.84559451
128MP0009672_abnormal_birth_weight0.84186887
129MP0001177_atelectasis0.83643186
130* MP0005391_vision/eye_phenotype0.83496149
131MP0004264_abnormal_extraembryonic_tissu0.82820329
132MP0001672_abnormal_embryogenesis/_devel0.82533907
133MP0005380_embryogenesis_phenotype0.82533907
134MP0003091_abnormal_cell_migration0.82155536
135MP0004134_abnormal_chest_morphology0.81936414
136* MP0002085_abnormal_embryonic_tissue0.81807248
137MP0002877_abnormal_melanocyte_morpholog0.81631251
138MP0002160_abnormal_reproductive_system0.80774013
139* MP0002925_abnormal_cardiovascular_devel0.79788922
140* MP0001286_abnormal_eye_development0.78521800
141MP0004043_abnormal_pH_regulation0.78296658
142MP0002295_abnormal_pulmonary_circulatio0.78023310
143* MP0002092_abnormal_eye_morphology0.77532897
144MP0005394_taste/olfaction_phenotype0.77473637
145MP0005499_abnormal_olfactory_system0.77473637
146MP0002168_other_aberrant_phenotype0.76743443
147MP0003880_abnormal_central_pattern0.76582980
148MP0002088_abnormal_embryonic_growth/wei0.76284733
149MP0002557_abnormal_social/conspecific_i0.75830487
150MP0005646_abnormal_pituitary_gland0.75351458
151* MP0003137_abnormal_impulse_conducting0.75109209
152MP0003984_embryonic_growth_retardation0.72662558

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)3.84620102
2Shallow orbits (HP:0000586)3.79476404
3Premature rupture of membranes (HP:0001788)3.52075074
4Ankle contracture (HP:0006466)3.11309439
5Broad metatarsal (HP:0001783)2.91978597
6Short 4th metacarpal (HP:0010044)2.88720034
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.88720034
8Atrophic scars (HP:0001075)2.75561016
9Abnormality of the 4th metacarpal (HP:0010012)2.67906360
10Aortic dissection (HP:0002647)2.62343226
11True hermaphroditism (HP:0010459)2.61824399
12Right ventricular cardiomyopathy (HP:0011663)2.61279772
13Coronal craniosynostosis (HP:0004440)2.60875310
14Aortic aneurysm (HP:0004942)2.54341812
15Pancreatic fibrosis (HP:0100732)2.53232638
16Type 1 muscle fiber predominance (HP:0003803)2.51088628
17Cerebral aneurysm (HP:0004944)2.49163817
18Pancreatic cysts (HP:0001737)2.48516416
19Aplasia/Hypoplasia of the tibia (HP:0005772)2.48001262
20Hypoplastic ischia (HP:0003175)2.46146856
21Supernumerary spleens (HP:0009799)2.40271028
22Mitral valve prolapse (HP:0001634)2.38768601
23Abnormality of the labia minora (HP:0012880)2.36872951
24Hepatoblastoma (HP:0002884)2.36779279
25Bifid tongue (HP:0010297)2.30711026
26Buphthalmos (HP:0000557)2.30294364
27Abnormality of the ischium (HP:0003174)2.29253590
28Bladder diverticulum (HP:0000015)2.28990462
29Overgrowth (HP:0001548)2.27144006
30Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.24234212
31Abnormality of midbrain morphology (HP:0002418)2.22717596
32Molar tooth sign on MRI (HP:0002419)2.22717596
33Intestinal atresia (HP:0011100)2.21519064
34Increased connective tissue (HP:0009025)2.20671004
35Nephronophthisis (HP:0000090)2.17781242
36Lymphangioma (HP:0100764)2.16833221
37Follicular hyperkeratosis (HP:0007502)2.16533553
38Soft skin (HP:0000977)2.11854274
39Neonatal short-limb short stature (HP:0008921)2.11832710
40Renal duplication (HP:0000075)2.11660098
41Anophthalmia (HP:0000528)2.10387132
42Mildly elevated creatine phosphokinase (HP:0008180)2.09971188
43Short tibia (HP:0005736)2.09486861
44Abnormality of abdominal situs (HP:0011620)2.09004854
45Abdominal situs inversus (HP:0003363)2.09004854
46Meckel diverticulum (HP:0002245)2.08744285
47Subacute progressive viral hepatitis (HP:0006572)2.06191323
48Hypoplastic labia majora (HP:0000059)2.05934438
49Deviation of the hallux (HP:0010051)2.05299344
50Bilateral microphthalmos (HP:0007633)2.05252907
51Bell-shaped thorax (HP:0001591)2.04248446
52Wide anterior fontanel (HP:0000260)2.03452910
53Broad thumb (HP:0011304)2.01887863
54Hyperglycinemia (HP:0002154)2.01689904
55Abnormality of the ileum (HP:0001549)2.01142519
56Spinal rigidity (HP:0003306)1.98769201
57Genital tract atresia (HP:0001827)1.98442275
58Hyporeflexia of lower limbs (HP:0002600)1.98180583
59Aplasia/Hypoplasia of the uvula (HP:0010293)1.97795560
60Chromsome breakage (HP:0040012)1.97712058
61Scapular winging (HP:0003691)1.97589303
62Turricephaly (HP:0000262)1.97573996
63Chromosomal breakage induced by crosslinking agents (HP:0003221)1.97546631
64Vaginal atresia (HP:0000148)1.95874832
65Septo-optic dysplasia (HP:0100842)1.95546795
66Asymmetry of the thorax (HP:0001555)1.94536967
67Dilatation of the ascending aorta (HP:0005111)1.94444044
68Absent radius (HP:0003974)1.92727103
69Abnormality of the phalanges of the 2nd finger (HP:0009541)1.92246694
70Hallux valgus (HP:0001822)1.91889421
71Exostoses (HP:0100777)1.91318738
72Broad ribs (HP:0000885)1.90130530
73Aneurysm (HP:0002617)1.89818856
74Hyperglycinuria (HP:0003108)1.89472808
75Fragile skin (HP:0001030)1.89170465
76Aplasia/Hypoplasia of the tongue (HP:0010295)1.87750408
77Aplasia involving forearm bones (HP:0009822)1.87545593
78Absent forearm bone (HP:0003953)1.87545593
79Abnormality of the labia majora (HP:0012881)1.87285475
80Gastrointestinal atresia (HP:0002589)1.86220558
81Medial flaring of the eyebrow (HP:0010747)1.85914791
82Mesomelia (HP:0003027)1.85637263
83Preaxial hand polydactyly (HP:0001177)1.84811951
84Bronchomalacia (HP:0002780)1.84639536
85Broad long bones (HP:0005622)1.84632383
86Abnormality of the renal medulla (HP:0100957)1.83901562
87Enlarged penis (HP:0000040)1.83882822
88Abnormality of the proximal phalanges of the hand (HP:0009834)1.83804074
89Short hallux (HP:0010109)1.83359533
90Ectopic kidney (HP:0000086)1.83012924
91Microglossia (HP:0000171)1.80116756
92Aplasia involving bones of the upper limbs (HP:0009823)1.79393648
93Aplasia of the phalanges of the hand (HP:0009802)1.79393648
94Aplasia involving bones of the extremities (HP:0009825)1.79393648
95Optic nerve hypoplasia (HP:0000609)1.79318923
96Abnormality of dentin (HP:0010299)1.78959334
97Cutaneous finger syndactyly (HP:0010554)1.78076867
98Anencephaly (HP:0002323)1.77230925
99Midline defect of the nose (HP:0004122)1.76965779
100Esophageal atresia (HP:0002032)1.76782508
101Fibular hypoplasia (HP:0003038)1.76656293
102Hyperextensible skin (HP:0000974)1.76478446
103Broad toe (HP:0001837)1.75768125
104Wormian bones (HP:0002645)1.74998579
105Dandy-Walker malformation (HP:0001305)1.74652207
106Tarsal synostosis (HP:0008368)1.74198691
107Vascular tortuosity (HP:0004948)1.74010601
108Blue sclerae (HP:0000592)1.73971676
109Arterial tortuosity (HP:0005116)1.73851381
110Abnormal lung lobation (HP:0002101)1.73076852
111Aplasia/Hypoplasia of the patella (HP:0006498)1.73058259
112Broad phalanx (HP:0006009)1.72911210
113Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72736090
114Cervical subluxation (HP:0003308)1.72685256
115Postaxial foot polydactyly (HP:0001830)1.72493430
116Increased variability in muscle fiber diameter (HP:0003557)1.71981874
117Abnormality of the distal phalanx of the thumb (HP:0009617)1.71620466
118Short humerus (HP:0005792)1.71505456
119Genu recurvatum (HP:0002816)1.71479827
120Patellar aplasia (HP:0006443)1.70607175
121Aplasia/hypoplasia of the humerus (HP:0006507)1.70556931
122Abnormality of serine family amino acid metabolism (HP:0010894)1.70473533
123Abnormality of glycine metabolism (HP:0010895)1.70473533
124* Colon cancer (HP:0003003)1.70394848
125Drooling (HP:0002307)1.70326082
126Labial hypoplasia (HP:0000066)1.69242030
127Bowel diverticulosis (HP:0005222)1.68460233
128Knee flexion contracture (HP:0006380)1.68063704
129Protruding tongue (HP:0010808)1.68018275
130Congenital primary aphakia (HP:0007707)1.67564595
131Postaxial hand polydactyly (HP:0001162)1.67389373
132Chronic hepatic failure (HP:0100626)1.67294762
133Gait imbalance (HP:0002141)1.67280725
134Broad phalanges of the hand (HP:0009768)1.67241278
135Broad finger (HP:0001500)1.67227766
136Chorioretinal atrophy (HP:0000533)1.65651413
137Fibular aplasia (HP:0002990)1.65090581
138Aplasia/Hypoplasia of the hallux (HP:0008362)1.64912633
139Hyperventilation (HP:0002883)1.64341152
140Macroorchidism (HP:0000053)1.64213384
141Cerebellar dysplasia (HP:0007033)1.64142421
142Back pain (HP:0003418)1.64023729
143Wrist flexion contracture (HP:0001239)1.63887270
144Renal hypoplasia (HP:0000089)1.63300064
145Hip contracture (HP:0003273)1.62431277
146Sclerocornea (HP:0000647)1.62255652
147Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.61951849
148Humeroradial synostosis (HP:0003041)1.61944512
149Synostosis involving the elbow (HP:0003938)1.61944512
150Type II lissencephaly (HP:0007260)1.61150937
151Abnormality of the 2nd finger (HP:0004100)1.60649011
152Birth length less than 3rd percentile (HP:0003561)1.60538389
153Scrotal hypoplasia (HP:0000046)1.60160887
154Thin bony cortex (HP:0002753)1.59921495
155Hypoplastic female external genitalia (HP:0012815)1.59704410
156Vitreoretinal degeneration (HP:0000655)1.58973245
157Limb-girdle muscle weakness (HP:0003325)1.58868030
158Tubular atrophy (HP:0000092)1.58730733
159Advanced eruption of teeth (HP:0006288)1.57720222
160Cystic liver disease (HP:0006706)1.57332497
161Abnormality of the calf musculature (HP:0001430)1.57304262
162Abnormality of chromosome stability (HP:0003220)1.56523672
163Aplasia/Hypoplasia of the sternum (HP:0006714)1.56378540
164Glioma (HP:0009733)1.56194141
165Synostosis of carpal bones (HP:0005048)1.55951212
166Embryonal renal neoplasm (HP:0011794)1.55593994
167Breast aplasia (HP:0100783)1.55374530
168Aplasia/Hypoplasia of the fibula (HP:0006492)1.55285540
169Micropenis (HP:0000054)1.54875893
170Synostosis involving bones of the feet (HP:0009140)1.54624586
171Synostosis involving bones of the lower limbs (HP:0009138)1.54624586
172Cutaneous syndactyly (HP:0012725)1.54591611
173Round ear (HP:0100830)1.54585138
174Joint laxity (HP:0001388)1.54116114
175Muscle fiber splitting (HP:0003555)1.53791588
176Abnormality of the middle phalanges of the toes (HP:0010183)1.53697177
177Preaxial foot polydactyly (HP:0001841)1.53612379
178Exercise-induced muscle cramps (HP:0003710)1.53221544
179Camptodactyly of toe (HP:0001836)1.52749680
180Maternal diabetes (HP:0009800)1.52380623
181Triphalangeal thumb (HP:0001199)1.52214965
182Elbow flexion contracture (HP:0002987)1.51928106
183Abnormality of the renal cortex (HP:0011035)1.51780758
184Aplasia/Hypoplasia of the breasts (HP:0010311)1.51746077
185Abnormality of alanine metabolism (HP:0010916)1.51665357
186Hyperalaninemia (HP:0003348)1.51665357
187Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.51665357

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.42887821
2DDR22.88657787
3TRIB32.84552074
4PDGFRA2.72295800
5MKNK22.66926716
6TTN2.58380144
7FRK2.58052573
8EPHB22.39948815
9BMPR1B2.35174848
10CASK2.32820901
11SIK12.31161977
12TNIK2.24803605
13PKN22.23195205
14MKNK12.22208113
15FGFR22.07483610
16FER2.02875214
17LATS22.00513458
18SRPK11.95448619
19LMTK21.84578727
20CDC71.81355154
21PRKD31.80587240
22MAP3K41.79493525
23ACVR1B1.74521466
24PTK61.73320680
25STK38L1.68104917
26MET1.64182395
27RIPK11.63984570
28TSSK61.63567035
29STK31.61583844
30FGFR11.59746609
31DMPK1.58382874
32PLK41.56724613
33PNCK1.55361736
34TRIM281.53012154
35NEK11.49873591
36CAMK1D1.41760167
37BRSK21.36524704
38CAMK1G1.36033931
39WEE11.35259306
40GRK11.32368169
41PAK31.28495506
42PTK21.26900908
43EPHA31.23714641
44PIK3CA1.23418105
45CDK121.21158286
46OXSR11.20544364
47EPHA21.18239530
48MTOR1.16482322
49MAP3K21.12359817
50PAK21.12278821
51EPHA41.12202198
52MAP4K21.08479203
53PDGFRB1.08357970
54BUB11.08036497
55OBSCN1.07098313
56ERBB31.05584585
57PLK11.02623760
58TAF11.00971570
59ADRBK21.00199213
60CDK60.99537650
61SCYL20.99478091
62ROCK10.98145481
63CSNK1G20.93709780
64DYRK20.93373314
65WNK40.92707369
66MAPK130.90029508
67ERBB20.89452506
68MAP2K70.88439221
69INSRR0.88216582
70MARK10.87212737
71PINK10.87205458
72TLK10.86933740
73AKT30.85232989
74DYRK30.84959001
75PDK30.84283244
76PDK40.84283244
77MUSK0.84029907
78NTRK10.83595799
79MAP3K100.83398313
80PRKCE0.82657194
81TYRO30.82470368
82CSNK1G30.82280899
83NUAK10.81850127
84KSR10.81791790
85WNK10.81570471
86PAK40.81294836
87NEK20.81275470
88RET0.79473504
89PHKG10.78826044
90PHKG20.78826044
91BMX0.77981191
92NEK90.77471491
93CHEK20.74509221
94BCR0.73552111
95STK390.73073834
96VRK10.72421516
97FGFR30.71176691
98MST1R0.69878080
99PBK0.68930812
100FLT30.68053223
101NLK0.67518213
102ATM0.66484807
103MST40.65704048
104LRRK20.65093613
105CDC42BPA0.62344957
106ATR0.61858478
107LIMK10.61714823
108DYRK1B0.61228814
109PRKCG0.61131207
110ICK0.60598809
111ILK0.59320441
112MAP2K10.59091108
113MAP3K30.58886904
114MELK0.57557258
115TIE10.54388128
116ERBB40.53921613
117PLK20.52984461
118GSK3A0.51857567
119PLK30.51351851
120CDK190.51198864
121SGK30.51013800
122PRKD10.50603020
123AURKB0.50130807
124TTK0.48907269
125KSR20.47370421
126ROCK20.46744233
127CAMK2A0.46347144
128STK380.45531077
129PDK20.45461972
130EEF2K0.45384199
131DYRK1A0.44596454
132CSNK1D0.44225178
133WNK30.42863495
134CSNK1A1L0.42379784
135STK240.42051833
136CSNK1E0.41650133
137CHEK10.41098866
138TRPM70.40316615
139BRD40.40313903
140PAK60.40291109
141RPS6KA40.40285643
142MAP3K70.40264848
143PASK0.39902766
144TGFBR10.39172665
145EIF2AK30.39037468
146PRKAA10.38939165
147MYLK0.38315932
148ADRBK10.37544155
149EIF2AK20.37068538
150PRKCH0.35718590
151CDK10.34829924
152SGK20.34727180
153CSNK1A10.34221874
154ZAK0.34048225
155INSR0.32975263
156AKT20.32693718
157PRKDC0.30312927
158CSNK1G10.30168992

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.79668158
2ECM-receptor interaction_Homo sapiens_hsa045122.60333517
3Basal cell carcinoma_Homo sapiens_hsa052172.49278618
4Adherens junction_Homo sapiens_hsa045202.35353902
5* Hippo signaling pathway_Homo sapiens_hsa043902.32172994
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.21372892
7Focal adhesion_Homo sapiens_hsa045102.10531336
8Hedgehog signaling pathway_Homo sapiens_hsa043402.10139178
9Non-homologous end-joining_Homo sapiens_hsa034502.09772458
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.04339532
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.99517853
12Fanconi anemia pathway_Homo sapiens_hsa034601.90905943
13Tight junction_Homo sapiens_hsa045301.86648270
14Proteoglycans in cancer_Homo sapiens_hsa052051.84842652
15Dilated cardiomyopathy_Homo sapiens_hsa054141.82386645
16Protein digestion and absorption_Homo sapiens_hsa049741.81087495
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.78423485
18Steroid biosynthesis_Homo sapiens_hsa001001.68448168
19* TGF-beta signaling pathway_Homo sapiens_hsa043501.67496991
20Homologous recombination_Homo sapiens_hsa034401.65400691
21Basal transcription factors_Homo sapiens_hsa030221.62299866
22Protein export_Homo sapiens_hsa030601.57184837
23* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.57101645
24Mismatch repair_Homo sapiens_hsa034301.49131439
25MicroRNAs in cancer_Homo sapiens_hsa052061.42725021
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.40558067
27Bladder cancer_Homo sapiens_hsa052191.40312982
28One carbon pool by folate_Homo sapiens_hsa006701.38778178
29Wnt signaling pathway_Homo sapiens_hsa043101.36506657
30Small cell lung cancer_Homo sapiens_hsa052221.35122452
31RNA degradation_Homo sapiens_hsa030181.32304754
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31819354
33Endometrial cancer_Homo sapiens_hsa052131.31792734
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.31117634
35Fatty acid biosynthesis_Homo sapiens_hsa000611.28890670
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.28761284
37Lysine degradation_Homo sapiens_hsa003101.27489815
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.24702848
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.23439477
40Phototransduction_Homo sapiens_hsa047441.23360376
41Melanogenesis_Homo sapiens_hsa049161.22930050
42Fatty acid metabolism_Homo sapiens_hsa012121.22372076
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.22069919
44Fatty acid degradation_Homo sapiens_hsa000711.21890592
45Axon guidance_Homo sapiens_hsa043601.20258290
46RNA polymerase_Homo sapiens_hsa030201.20129277
47RNA transport_Homo sapiens_hsa030131.19249010
48mTOR signaling pathway_Homo sapiens_hsa041501.18910966
49Amoebiasis_Homo sapiens_hsa051461.16060635
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.14063874
51Prostate cancer_Homo sapiens_hsa052151.11847500
52Cell cycle_Homo sapiens_hsa041101.11723292
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11683535
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.11378036
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.10874775
56Insulin resistance_Homo sapiens_hsa049311.10018671
57Propanoate metabolism_Homo sapiens_hsa006401.08912397
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08761056
59Central carbon metabolism in cancer_Homo sapiens_hsa052301.07045235
60AMPK signaling pathway_Homo sapiens_hsa041521.06175385
61Melanoma_Homo sapiens_hsa052181.06017863
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05605894
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02503816
64Glioma_Homo sapiens_hsa052141.02487650
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.02280156
66Nicotine addiction_Homo sapiens_hsa050331.02044005
67Sulfur metabolism_Homo sapiens_hsa009200.99982517
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97804353
69beta-Alanine metabolism_Homo sapiens_hsa004100.97782049
70Pyruvate metabolism_Homo sapiens_hsa006200.97459160
71DNA replication_Homo sapiens_hsa030300.96565233
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96142842
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.94459818
74Dorso-ventral axis formation_Homo sapiens_hsa043200.93848304
75Nucleotide excision repair_Homo sapiens_hsa034200.93685332
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93408908
77Linoleic acid metabolism_Homo sapiens_hsa005910.93160317
78Glucagon signaling pathway_Homo sapiens_hsa049220.92905771
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.92186852
80Renal cell carcinoma_Homo sapiens_hsa052110.91956406
81Pathways in cancer_Homo sapiens_hsa052000.90792197
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90463520
83Insulin signaling pathway_Homo sapiens_hsa049100.90389385
84PI3K-Akt signaling pathway_Homo sapiens_hsa041510.90151983
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89580071
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88913435
87Thyroid cancer_Homo sapiens_hsa052160.88828089
88Chronic myeloid leukemia_Homo sapiens_hsa052200.87912088
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86714934
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86274476
91Thyroid hormone synthesis_Homo sapiens_hsa049180.86194725
92Ether lipid metabolism_Homo sapiens_hsa005650.85024510
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84855030
94PPAR signaling pathway_Homo sapiens_hsa033200.84404720
95Caffeine metabolism_Homo sapiens_hsa002320.84146895
96Colorectal cancer_Homo sapiens_hsa052100.83889476
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82164177
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81369673
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81253606
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81027087
101Estrogen signaling pathway_Homo sapiens_hsa049150.80572876
102Taste transduction_Homo sapiens_hsa047420.80225519
103Circadian rhythm_Homo sapiens_hsa047100.79258229
104Type II diabetes mellitus_Homo sapiens_hsa049300.75197023
105Butanoate metabolism_Homo sapiens_hsa006500.75172972
106Arginine and proline metabolism_Homo sapiens_hsa003300.74977753
107Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74952771
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74519886
109Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73711937
110Fat digestion and absorption_Homo sapiens_hsa049750.73601424
111Bile secretion_Homo sapiens_hsa049760.71986335
112Rap1 signaling pathway_Homo sapiens_hsa040150.71912710
113Purine metabolism_Homo sapiens_hsa002300.71188846
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68794311
115Viral myocarditis_Homo sapiens_hsa054160.68466298
116Fatty acid elongation_Homo sapiens_hsa000620.67852002
117Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67619083
118Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66606714
119Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66200185
120Cardiac muscle contraction_Homo sapiens_hsa042600.65645217
121Gap junction_Homo sapiens_hsa045400.65215757
122Retinol metabolism_Homo sapiens_hsa008300.64160914
123Pancreatic cancer_Homo sapiens_hsa052120.64062565
124mRNA surveillance pathway_Homo sapiens_hsa030150.63617597
125Base excision repair_Homo sapiens_hsa034100.63389956
126Peroxisome_Homo sapiens_hsa041460.62549553
127p53 signaling pathway_Homo sapiens_hsa041150.60999863
128Ovarian steroidogenesis_Homo sapiens_hsa049130.60933641
129FoxO signaling pathway_Homo sapiens_hsa040680.60674128
130Vitamin digestion and absorption_Homo sapiens_hsa049770.60302565
131Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59626043
132Spliceosome_Homo sapiens_hsa030400.58401213
133Starch and sucrose metabolism_Homo sapiens_hsa005000.57663240
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.57108706
135Glutamatergic synapse_Homo sapiens_hsa047240.56957116
136Primary bile acid biosynthesis_Homo sapiens_hsa001200.56867880
137Histidine metabolism_Homo sapiens_hsa003400.56716901
138Renin secretion_Homo sapiens_hsa049240.56503808
139Maturity onset diabetes of the young_Homo sapiens_hsa049500.56276293
140Leukocyte transendothelial migration_Homo sapiens_hsa046700.55554362
141Steroid hormone biosynthesis_Homo sapiens_hsa001400.54879156
142Serotonergic synapse_Homo sapiens_hsa047260.54864285
143Adipocytokine signaling pathway_Homo sapiens_hsa049200.54648409
144Circadian entrainment_Homo sapiens_hsa047130.54648095
145Alcoholism_Homo sapiens_hsa050340.54194349
146Gastric acid secretion_Homo sapiens_hsa049710.53719236
147Metabolic pathways_Homo sapiens_hsa011000.53465904
148Tryptophan metabolism_Homo sapiens_hsa003800.53191858
149Mineral absorption_Homo sapiens_hsa049780.52631245
150ErbB signaling pathway_Homo sapiens_hsa040120.52582244
151Oocyte meiosis_Homo sapiens_hsa041140.52566369
152Arginine biosynthesis_Homo sapiens_hsa002200.51973171
153GABAergic synapse_Homo sapiens_hsa047270.51764547
154GnRH signaling pathway_Homo sapiens_hsa049120.51541989
155Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51317429
156Carbon metabolism_Homo sapiens_hsa012000.51082745
157Selenocompound metabolism_Homo sapiens_hsa004500.49772731
158Notch signaling pathway_Homo sapiens_hsa043300.48711990
159Insulin secretion_Homo sapiens_hsa049110.48030915
160Vitamin B6 metabolism_Homo sapiens_hsa007500.47956771
161Renin-angiotensin system_Homo sapiens_hsa046140.47239910
162Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47194608
163Non-small cell lung cancer_Homo sapiens_hsa052230.47016305
164Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46807782
165ABC transporters_Homo sapiens_hsa020100.46042043

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