BMPR1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular potassium ion homeostasis (GO:0030007)4.93920741
2behavioral response to nicotine (GO:0035095)4.76892434
3regulation of acrosome reaction (GO:0060046)4.63972076
4L-amino acid import (GO:0043092)4.55683462
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.39988020
6negative regulation of astrocyte differentiation (GO:0048712)4.18025486
7amino acid import (GO:0043090)4.05573025
8protein polyglutamylation (GO:0018095)3.98195313
9locomotory exploration behavior (GO:0035641)3.88705094
10lateral sprouting from an epithelium (GO:0060601)3.84240647
11sodium ion export (GO:0071436)3.82546750
12presynaptic membrane assembly (GO:0097105)3.81532180
13branching involved in prostate gland morphogenesis (GO:0060442)3.80493209
14epithelial cilium movement (GO:0003351)3.79350881
15regulation of DNA endoreduplication (GO:0032875)3.74798546
16water-soluble vitamin biosynthetic process (GO:0042364)3.68951165
17response to auditory stimulus (GO:0010996)3.65517103
18somite development (GO:0061053)3.62864086
19neurotransmitter-gated ion channel clustering (GO:0072578)3.59589820
20sulfation (GO:0051923)3.56681762
21prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.54918169
22potassium ion homeostasis (GO:0055075)3.54892862
23C4-dicarboxylate transport (GO:0015740)3.51976590
24presynaptic membrane organization (GO:0097090)3.50178686
25prostate gland epithelium morphogenesis (GO:0060740)3.46059500
26membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.45398906
27cell proliferation in forebrain (GO:0021846)3.43583661
28potassium ion import (GO:0010107)3.43088452
29negative regulation of sodium ion transport (GO:0010766)3.41516230
30cilium movement (GO:0003341)3.38442371
31regulation of mesoderm development (GO:2000380)3.34763766
32serotonin metabolic process (GO:0042428)3.30810798
33limb bud formation (GO:0060174)3.27934916
34cellular sodium ion homeostasis (GO:0006883)3.25467730
35axoneme assembly (GO:0035082)3.24899294
36regulation of calcium ion-dependent exocytosis (GO:0017158)3.21880300
37artery development (GO:0060840)3.19579759
38glial cell proliferation (GO:0014009)3.18688271
39otic vesicle formation (GO:0030916)3.16025809
40myelination in peripheral nervous system (GO:0022011)3.12723419
41peripheral nervous system axon ensheathment (GO:0032292)3.12723419
42alanine transport (GO:0032328)3.11903724
43primary amino compound metabolic process (GO:1901160)3.11484199
44negative regulation of transcription regulatory region DNA binding (GO:2000678)3.10511845
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.09776423
46mitochondrial respiratory chain complex I assembly (GO:0032981)3.09776423
47NADH dehydrogenase complex assembly (GO:0010257)3.09776423
48cell communication by electrical coupling (GO:0010644)3.06565801
49protein complex biogenesis (GO:0070271)3.04513522
50regulation of clathrin-mediated endocytosis (GO:2000369)3.01585625
51* ovulation cycle (GO:0042698)3.00071708
52phenol-containing compound catabolic process (GO:0019336)2.99877181
53negative regulation of fatty acid transport (GO:2000192)2.96711683
54gamma-aminobutyric acid transport (GO:0015812)2.96271207
55indolalkylamine metabolic process (GO:0006586)2.93924697
56negative regulation of hormone biosynthetic process (GO:0032353)2.93464722
57negative regulation of hormone metabolic process (GO:0032351)2.93464722
58pyrimidine nucleobase catabolic process (GO:0006208)2.92648529
59detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.90091956
60regulation of short-term neuronal synaptic plasticity (GO:0048172)2.89959735
61synaptic vesicle docking involved in exocytosis (GO:0016081)2.89672297
62negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.88521813
63L-serine transport (GO:0015825)2.87620815
64proline transport (GO:0015824)2.86579854
65DNA deamination (GO:0045006)2.86178309
66auditory behavior (GO:0031223)2.85888587
67negative regulation of systemic arterial blood pressure (GO:0003085)2.85516470
68magnesium ion transport (GO:0015693)2.85419466
69cilium or flagellum-dependent cell motility (GO:0001539)2.85024825
70relaxation of cardiac muscle (GO:0055119)2.84859217
71glutamate secretion (GO:0014047)2.84424656
72indolalkylamine catabolic process (GO:0046218)2.82830070
73tryptophan catabolic process (GO:0006569)2.82830070
74indole-containing compound catabolic process (GO:0042436)2.82830070
75regulation of cilium movement (GO:0003352)2.82271562
76neuronal action potential propagation (GO:0019227)2.81977261
77positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.80863469
78dendritic spine morphogenesis (GO:0060997)2.79953217
79mechanosensory behavior (GO:0007638)2.79041048
80parturition (GO:0007567)2.78293773
81replication fork processing (GO:0031297)2.78161734
82mitochondrial respiratory chain complex assembly (GO:0033108)2.77192452
83axonemal dynein complex assembly (GO:0070286)2.76991517
84nonmotile primary cilium assembly (GO:0035058)2.76985761
85detection of light stimulus involved in visual perception (GO:0050908)2.76697197
86detection of light stimulus involved in sensory perception (GO:0050962)2.76697197
87regulation of glomerulus development (GO:0090192)2.76205705
88indole-containing compound metabolic process (GO:0042430)2.75216807
89regulation of beta-amyloid formation (GO:1902003)2.74962592
90kynurenine metabolic process (GO:0070189)2.74656409
91synaptic vesicle maturation (GO:0016188)2.72698496
92G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.72101511
93cilium organization (GO:0044782)2.71293726
94epithelial cell maturation (GO:0002070)2.69433622
95regulation of astrocyte differentiation (GO:0048710)2.69125659
96cerebral cortex neuron differentiation (GO:0021895)2.69031239
97membrane repolarization (GO:0086009)2.68111342
98cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.67992229
99positive regulation of potassium ion transmembrane transport (GO:1901381)2.67849188
100layer formation in cerebral cortex (GO:0021819)2.67260931
101membrane depolarization during action potential (GO:0086010)2.67250535
102positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.67088889
103L-fucose catabolic process (GO:0042355)2.66538620
104fucose catabolic process (GO:0019317)2.66538620
105L-fucose metabolic process (GO:0042354)2.66538620
106positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.65704814
107cornea development in camera-type eye (GO:0061303)2.65199075
108positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.64319553
109regulation of neurotransmitter uptake (GO:0051580)2.63622109
110photoreceptor cell development (GO:0042461)2.63362257
111DNA double-strand break processing (GO:0000729)2.62697724
112adaptation of signaling pathway (GO:0023058)2.62597625
113negative regulation of DNA-dependent DNA replication (GO:2000104)2.62472824
114neuronal action potential (GO:0019228)2.62415826
115cilium assembly (GO:0042384)2.61659432
116regulation of phospholipid biosynthetic process (GO:0071071)2.61653097
117positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.59887387
118prostate gland growth (GO:0060736)2.59401449
119regulation of receptor binding (GO:1900120)2.57778037
120transmission of nerve impulse (GO:0019226)2.57741540
121intraciliary transport (GO:0042073)2.56449381
122limb development (GO:0060173)2.56304720
123appendage development (GO:0048736)2.56304720
124regulation of non-canonical Wnt signaling pathway (GO:2000050)2.54459293
125regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.53815187
126spinal cord development (GO:0021510)2.53567796
127replicative senescence (GO:0090399)2.52254056
128synaptic transmission, glutamatergic (GO:0035249)2.50428874
129regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.50181750
130positive regulation of glomerulus development (GO:0090193)2.49493825
131cellular response to ATP (GO:0071318)2.49286091
132response to pheromone (GO:0019236)2.49258224
133neuron cell-cell adhesion (GO:0007158)2.49235141
134vocalization behavior (GO:0071625)2.49032512
135neurotransmitter uptake (GO:0001504)2.48912214
136negative regulation of glial cell differentiation (GO:0045686)2.47824208
137negative regulation of membrane potential (GO:0045837)2.47359076
138dendrite morphogenesis (GO:0048813)2.47191140
139retinal cone cell development (GO:0046549)2.46999272
140regulation of potassium ion transmembrane transport (GO:1901379)2.46837165
141axon ensheathment in central nervous system (GO:0032291)2.46031076
142central nervous system myelination (GO:0022010)2.46031076
143glutamate receptor signaling pathway (GO:0007215)2.45457250
144piRNA metabolic process (GO:0034587)2.45368843
145innervation (GO:0060384)2.45193508
146reflex (GO:0060004)2.45020242
147cilium morphogenesis (GO:0060271)2.44958162
148regulation of membrane repolarization (GO:0060306)2.43956709
149eye photoreceptor cell development (GO:0042462)2.43637494
150synaptic vesicle exocytosis (GO:0016079)2.42803836
151spinal cord motor neuron differentiation (GO:0021522)2.42682713
152kidney morphogenesis (GO:0060993)2.42487491
153long-term memory (GO:0007616)2.40855790
154hormone catabolic process (GO:0042447)2.40794730
155negative regulation of synaptic transmission, GABAergic (GO:0032229)2.40017928
156positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.38775631
157tryptophan metabolic process (GO:0006568)2.38019069
158exploration behavior (GO:0035640)2.37489658
159regulation of neuronal synaptic plasticity (GO:0048168)2.37224926
160positive regulation of potassium ion transport (GO:0043268)2.36477463
161apical protein localization (GO:0045176)2.36272622
162inositol phosphate-mediated signaling (GO:0048016)2.35692108
163negative regulation of cytosolic calcium ion concentration (GO:0051481)2.34029348
164membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.33095152
165regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.32789229
166long-term synaptic potentiation (GO:0060291)2.32741041
167glycine transport (GO:0015816)2.31369707
168positive regulation of cellular amide metabolic process (GO:0034250)2.29421714
169neuronal ion channel clustering (GO:0045161)2.29396200
170regulation of synaptic transmission, glutamatergic (GO:0051966)2.29087322
171regulation of synapse structural plasticity (GO:0051823)2.28726727
172chondroitin sulfate catabolic process (GO:0030207)2.28713429
173membrane repolarization during action potential (GO:0086011)2.28486092
174regulation of timing of cell differentiation (GO:0048505)2.27952630
175beta-amyloid metabolic process (GO:0050435)2.27859102
176mechanoreceptor differentiation (GO:0042490)2.26910010
177regulation of synaptic vesicle exocytosis (GO:2000300)2.26119561
178cellular response to cholesterol (GO:0071397)2.25894828
179one-carbon compound transport (GO:0019755)2.25789341
180serine transport (GO:0032329)2.25533360
181ionotropic glutamate receptor signaling pathway (GO:0035235)2.25158822
182postsynaptic membrane organization (GO:0001941)2.25058064

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.26732226
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.10025268
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.67985346
4VDR_22108803_ChIP-Seq_LS180_Human2.65482938
5GBX2_23144817_ChIP-Seq_PC3_Human2.55740998
6AR_21572438_ChIP-Seq_LNCaP_Human2.49241793
7IGF1R_20145208_ChIP-Seq_DFB_Human2.35632803
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.29442228
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.25375813
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.23588372
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.23588372
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.22501541
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.20853292
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.20515864
15TAF15_26573619_Chip-Seq_HEK293_Human2.19655433
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.16260459
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.10400666
18* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.10229357
19EWS_26573619_Chip-Seq_HEK293_Human2.09295944
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.03655802
21MTF2_20144788_ChIP-Seq_MESCs_Mouse1.98546371
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.95406980
23JARID2_20075857_ChIP-Seq_MESCs_Mouse1.92004033
24* RNF2_27304074_Chip-Seq_ESCs_Mouse1.88387505
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.86602548
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.85806692
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.79336528
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.73218199
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72645948
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.67168219
31* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.66762680
32* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.66753711
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65883480
34RXR_22108803_ChIP-Seq_LS180_Human1.64653264
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62924986
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62675813
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.61388140
38ER_23166858_ChIP-Seq_MCF-7_Human1.57140731
39AHR_22903824_ChIP-Seq_MCF-7_Human1.56348718
40* SMAD4_21799915_ChIP-Seq_A2780_Human1.56259467
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55062877
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.53660257
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53041123
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.52043830
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.50211232
46DROSHA_22980978_ChIP-Seq_HELA_Human1.49312846
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48715315
48SUZ12_27294783_Chip-Seq_ESCs_Mouse1.48064766
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47902148
50IRF1_19129219_ChIP-ChIP_H3396_Human1.47080412
51* ARNT_22903824_ChIP-Seq_MCF-7_Human1.45999513
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.45608905
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42806982
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40670256
55CBP_20019798_ChIP-Seq_JUKART_Human1.40670256
56TRIM28_21343339_ChIP-Seq_HEK293_Human1.40604748
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40416279
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40114772
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.38824916
60ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.37683970
61* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.36262792
62* AR_25329375_ChIP-Seq_VCAP_Human1.35395590
63* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33508987
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33144167
65P300_19829295_ChIP-Seq_ESCs_Human1.32074939
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31797912
67EP300_21415370_ChIP-Seq_HL-1_Mouse1.31471846
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31317787
69TP53_16413492_ChIP-PET_HCT116_Human1.30943094
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30758594
71* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29792632
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.29712807
73BCAT_22108803_ChIP-Seq_LS180_Human1.28827428
74CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28204258
75FOXM1_26456572_ChIP-Seq_MCF-7_Human1.27470773
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25685980
77ERG_21242973_ChIP-ChIP_JURKAT_Human1.25388221
78SALL1_21062744_ChIP-ChIP_HESCs_Human1.25363301
79STAT3_23295773_ChIP-Seq_U87_Human1.23466827
80AR_19668381_ChIP-Seq_PC3_Human1.23159646
81TP53_18474530_ChIP-ChIP_U2OS_Human1.22256030
82* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21834424
83RING1B_27294783_Chip-Seq_ESCs_Mouse1.21771788
84BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21425629
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20722037
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20368149
87* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18603375
88RARB_27405468_Chip-Seq_BRAIN_Mouse1.18003796
89AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.17636229
90TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.17456824
91EZH2_27294783_Chip-Seq_NPCs_Mouse1.17404868
92TCF4_22108803_ChIP-Seq_LS180_Human1.16690918
93ZNF274_21170338_ChIP-Seq_K562_Hela1.16266031
94NRF2_20460467_ChIP-Seq_MEFs_Mouse1.16214785
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.16214785
96PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16178244
97FUS_26573619_Chip-Seq_HEK293_Human1.15918619
98TCF4_18268006_ChIP-ChIP_LS174T_Human1.14555481
99* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14323386
100NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13672673
101KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13661369
102TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13596981
103NFE2_27457419_Chip-Seq_LIVER_Mouse1.12680848
104* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12303846
105* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12278339
106TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12184257
107HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.11972273
108* SOX2_21211035_ChIP-Seq_LN229_Gbm1.11737835
109TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11530922
110* TAL1_26923725_Chip-Seq_HPCs_Mouse1.10659689
111RING1B_27294783_Chip-Seq_NPCs_Mouse1.10150550
112* REST_21632747_ChIP-Seq_MESCs_Mouse1.09724643
113CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09715909
114* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09448547
115FLI1_21867929_ChIP-Seq_TH2_Mouse1.09345595
116* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09066751
117SMAD3_21741376_ChIP-Seq_HESCs_Human1.08307804
118TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08015523
119POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08015523
120JUN_21703547_ChIP-Seq_K562_Human1.07983887
121KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07378385
122* P53_22387025_ChIP-Seq_ESCs_Mouse1.07053696
123WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06782051
124* SOX2_19829295_ChIP-Seq_ESCs_Human1.06761191
125* NANOG_19829295_ChIP-Seq_ESCs_Human1.06761191
126RUNX2_22187159_ChIP-Seq_PCA_Human1.05881454
127TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05073551
128BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04686987
129SMAD4_21741376_ChIP-Seq_EPCs_Human1.04659433
130TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04090141
131PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03201424
132* TCF4_23295773_ChIP-Seq_U87_Human1.03095119
133RNF2_27304074_Chip-Seq_NSC_Mouse1.02989320
134* NANOG_18555785_Chip-Seq_ESCs_Mouse1.01763889
135* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00886480
136P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00692064
137GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00362830
138ISL1_27105846_Chip-Seq_CPCs_Mouse0.99266843
139PRDM14_20953172_ChIP-Seq_ESCs_Human0.98297605
140ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97388969

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo3.30881192
2MP0004859_abnormal_synaptic_plasticity3.27427701
3MP0005646_abnormal_pituitary_gland3.14931318
4MP0009384_cardiac_valve_regurgitation2.90465521
5MP0004885_abnormal_endolymph2.73544708
6MP0000566_synostosis2.64028600
7MP0000537_abnormal_urethra_morphology2.49777386
8MP0001485_abnormal_pinna_reflex2.35137744
9MP0010386_abnormal_urinary_bladder2.34526483
10MP0005394_taste/olfaction_phenotype2.32022218
11MP0005499_abnormal_olfactory_system2.32022218
12MP0002638_abnormal_pupillary_reflex2.30875631
13MP0008789_abnormal_olfactory_epithelium2.29744601
14MP0001984_abnormal_olfaction2.22472258
15MP0008877_abnormal_DNA_methylation2.20385281
16MP0010234_abnormal_vibrissa_follicle2.18835802
17MP0004270_analgesia2.17585780
18MP0005551_abnormal_eye_electrophysiolog2.12039962
19MP0001486_abnormal_startle_reflex2.06961763
20MP0003646_muscle_fatigue2.03578012
21MP0002102_abnormal_ear_morphology2.01406643
22MP0003635_abnormal_synaptic_transmissio1.97018940
23MP0004858_abnormal_nervous_system1.95140464
24MP0010030_abnormal_orbit_morphology1.92813992
25MP0002160_abnormal_reproductive_system1.89262664
26MP0002837_dystrophic_cardiac_calcinosis1.87670076
27MP0005647_abnormal_sex_gland1.86698304
28MP0002734_abnormal_mechanical_nocicepti1.85186351
29MP0005248_abnormal_Harderian_gland1.79969489
30MP0009053_abnormal_anal_canal1.75817784
31MP0005310_abnormal_salivary_gland1.75155741
32MP0001299_abnormal_eye_distance/1.71111818
33MP0002735_abnormal_chemical_nociception1.69232971
34MP0002009_preneoplasia1.68311189
35MP0002063_abnormal_learning/memory/cond1.68212229
36MP0003690_abnormal_glial_cell1.67370857
37MP0002938_white_spotting1.66317213
38MP0003329_amyloid_beta_deposits1.63083972
39MP0004133_heterotaxia1.61626294
40MP0002909_abnormal_adrenal_gland1.61348644
41MP0008875_abnormal_xenobiotic_pharmacok1.60629120
42MP0004142_abnormal_muscle_tone1.60478431
43MP0005171_absent_coat_pigmentation1.58450746
44MP0009745_abnormal_behavioral_response1.57826302
45MP0001502_abnormal_circadian_rhythm1.55531735
46MP0008872_abnormal_physiological_respon1.54486984
47MP0000778_abnormal_nervous_system1.53009991
48* MP0005253_abnormal_eye_physiology1.52722010
49MP0001346_abnormal_lacrimal_gland1.50650469
50MP0002557_abnormal_social/conspecific_i1.46618593
51MP0003283_abnormal_digestive_organ1.46074978
52MP0003011_delayed_dark_adaptation1.43858621
53MP0004742_abnormal_vestibular_system1.41712285
54MP0000049_abnormal_middle_ear1.41324714
55MP0005187_abnormal_penis_morphology1.40807422
56MP0002572_abnormal_emotion/affect_behav1.40514624
57MP0002234_abnormal_pharynx_morphology1.39219799
58MP0003942_abnormal_urinary_system1.34189621
59MP0000534_abnormal_ureter_morphology1.32532066
60MP0002138_abnormal_hepatobiliary_system1.31990768
61MP0002254_reproductive_system_inflammat1.30804494
62* MP0009250_abnormal_appendicular_skeleto1.30216815
63* MP0003937_abnormal_limbs/digits/tail_de1.28803372
64MP0006276_abnormal_autonomic_nervous1.27765943
65MP0000631_abnormal_neuroendocrine_gland1.27759265
66MP0002653_abnormal_ependyma_morphology1.27502972
67MP0002064_seizures1.26687888
68MP0000383_abnormal_hair_follicle1.23906369
69MP0002249_abnormal_larynx_morphology1.23796573
70MP0002282_abnormal_trachea_morphology1.22910946
71* MP0005389_reproductive_system_phenotype1.22467610
72MP0001529_abnormal_vocalization1.22214421
73MP0009046_muscle_twitch1.21195831
74MP0000372_irregular_coat_pigmentation1.21158282
75MP0005377_hearing/vestibular/ear_phenot1.21096184
76MP0003878_abnormal_ear_physiology1.21096184
77MP0003119_abnormal_digestive_system1.18701413
78MP0000569_abnormal_digit_pigmentation1.17692024
79MP0002233_abnormal_nose_morphology1.16224495
80MP0002876_abnormal_thyroid_physiology1.15625759
81MP0001501_abnormal_sleep_pattern1.15084746
82MP0003195_calcinosis1.13929866
83* MP0002752_abnormal_somatic_nervous1.11503131
84MP0004043_abnormal_pH_regulation1.11439405
85MP0001177_atelectasis1.08125848
86MP0002751_abnormal_autonomic_nervous1.07902686
87MP0008569_lethality_at_weaning1.07856060
88MP0003880_abnormal_central_pattern1.06531198
89MP0001440_abnormal_grooming_behavior1.05963447
90MP0002163_abnormal_gland_morphology1.05040619
91MP0005423_abnormal_somatic_nervous1.04931138
92* MP0005195_abnormal_posterior_eye1.04714485
93MP0000579_abnormal_nail_morphology1.03887201
94MP0010678_abnormal_skin_adnexa1.01347761
95MP0003755_abnormal_palate_morphology0.99961327
96MP0001293_anophthalmia0.99261632
97MP0004233_abnormal_muscle_weight0.98635491
98MP0002272_abnormal_nervous_system0.98475319
99MP0000955_abnormal_spinal_cord0.98087549
100* MP0002882_abnormal_neuron_morphology0.97949035
101MP0001963_abnormal_hearing_physiology0.97373924
102MP0002736_abnormal_nociception_after0.96682645
103MP0001970_abnormal_pain_threshold0.96531009
104MP0001968_abnormal_touch/_nociception0.95527771
105MP0003632_abnormal_nervous_system0.94396002
106MP0003633_abnormal_nervous_system0.93670772
107MP0008775_abnormal_heart_ventricle0.93138397
108MP0004215_abnormal_myocardial_fiber0.93089776
109MP0000604_amyloidosis0.92991090
110MP0002067_abnormal_sensory_capabilities0.92058357
111MP0002090_abnormal_vision0.91539889
112MP0002928_abnormal_bile_duct0.91433978
113MP0000026_abnormal_inner_ear0.90034206
114MP0000613_abnormal_salivary_gland0.89808018
115MP0004264_abnormal_extraembryonic_tissu0.89148962
116MP0003631_nervous_system_phenotype0.88745348
117MP0003279_aneurysm0.88402278
118MP0002152_abnormal_brain_morphology0.88391919
119MP0000647_abnormal_sebaceous_gland0.84960532
120MP0004145_abnormal_muscle_electrophysio0.82609538
121MP0002184_abnormal_innervation0.81702807
122MP0001905_abnormal_dopamine_level0.81498909
123MP0002116_abnormal_craniofacial_bone0.81067690
124MP0006292_abnormal_olfactory_placode0.80749988
125MP0003938_abnormal_ear_development0.80681386
126MP0001765_abnormal_ion_homeostasis0.80605054
127MP0000427_abnormal_hair_cycle0.80237077
128MP0004085_abnormal_heartbeat0.79350564
129MP0000428_abnormal_craniofacial_morphol0.79141642
130MP0000230_abnormal_systemic_arterial0.79078936
131MP0002295_abnormal_pulmonary_circulatio0.78521920
132MP0005386_behavior/neurological_phenoty0.78150911
133MP0004924_abnormal_behavior0.78150911
134MP0005379_endocrine/exocrine_gland_phen0.77756748
135MP0003634_abnormal_glial_cell0.76806837
136MP0002277_abnormal_respiratory_mucosa0.76649413
137MP0000462_abnormal_digestive_system0.76420341
138MP0000538_abnormal_urinary_bladder0.75528750
139MP0002733_abnormal_thermal_nociception0.74889793
140* MP0006072_abnormal_retinal_apoptosis0.74650180
141MP0004134_abnormal_chest_morphology0.70744847
142MP0003787_abnormal_imprinting0.70058764
143MP0003136_yellow_coat_color0.69392987
144MP0003941_abnormal_skin_development0.66895208

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cochlea (HP:0000375)4.65940003
2True hermaphroditism (HP:0010459)4.46644569
3* Aplasia involving bones of the extremities (HP:0009825)4.28387550
4* Aplasia involving bones of the upper limbs (HP:0009823)4.28387550
5* Aplasia of the phalanges of the hand (HP:0009802)4.28387550
6Pancreatic cysts (HP:0001737)4.25385979
7Potter facies (HP:0002009)4.21966500
8Facial shape deformation (HP:0011334)4.21966500
9Pancreatic fibrosis (HP:0100732)4.13483846
10Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.79773152
11Short 1st metacarpal (HP:0010034)3.79773152
12Nephronophthisis (HP:0000090)3.60161023
13Humeroradial synostosis (HP:0003041)3.57771600
14Synostosis involving the elbow (HP:0003938)3.57771600
15Megalencephaly (HP:0001355)3.54703050
16Abnormality of midbrain morphology (HP:0002418)3.53930625
17Molar tooth sign on MRI (HP:0002419)3.53930625
18Morphological abnormality of the inner ear (HP:0011390)3.37798687
19Cutaneous finger syndactyly (HP:0010554)3.25562180
20Abnormality of the 1st metacarpal (HP:0010009)3.25519807
21Cutaneous syndactyly (HP:0012725)3.19488516
22Long nose (HP:0003189)3.16516254
23Abnormality of the renal medulla (HP:0100957)3.12252342
24Abnormality of the nasal septum (HP:0000419)3.10708668
25Congenital stationary night blindness (HP:0007642)3.06273542
26Absent/shortened dynein arms (HP:0200106)2.98225597
27Dynein arm defect of respiratory motile cilia (HP:0012255)2.98225597
28Abolished electroretinogram (ERG) (HP:0000550)2.89894209
29Medial flaring of the eyebrow (HP:0010747)2.89466714
30Focal motor seizures (HP:0011153)2.87319739
31Aplasia/Hypoplasia of the tibia (HP:0005772)2.84554073
32Morphological abnormality of the middle ear (HP:0008609)2.84412769
33Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.82709934
34Hypoplastic nipples (HP:0002557)2.81892233
35* Abnormality of the middle phalanges of the toes (HP:0010183)2.80227627
36Abnormal respiratory epithelium morphology (HP:0012253)2.78819255
37Abnormal respiratory motile cilium morphology (HP:0005938)2.78819255
38Congenital, generalized hypertrichosis (HP:0004540)2.77799443
39Cystic liver disease (HP:0006706)2.74694092
40Abnormal ciliary motility (HP:0012262)2.72685479
41Abnormality of the renal cortex (HP:0011035)2.72218032
42Short tibia (HP:0005736)2.70167859
43* Short hallux (HP:0010109)2.68246576
44Lip pit (HP:0100267)2.67769766
45Short phalanx of the thumb (HP:0009660)2.66400644
46Papillary thyroid carcinoma (HP:0002895)2.63620841
47Asplenia (HP:0001746)2.61725758
48Aplasia/Hypoplasia of the spleen (HP:0010451)2.52655441
49Chronic hepatic failure (HP:0100626)2.51167006
50Aplasia/Hypoplasia of the sternum (HP:0006714)2.48352968
51Decreased circulating renin level (HP:0003351)2.44634604
52* Aplasia/Hypoplasia of the hallux (HP:0008362)2.42363166
53Sclerocornea (HP:0000647)2.42192293
54Abnormal respiratory motile cilium physiology (HP:0012261)2.42073364
55Aplasia/Hypoplasia of the tongue (HP:0010295)2.39071628
56Gait imbalance (HP:0002141)2.38541919
57Methylmalonic acidemia (HP:0002912)2.37382038
58Postaxial foot polydactyly (HP:0001830)2.36743311
59Abnormal finger flexion creases (HP:0006143)2.36063978
60Abnormality of secondary sexual hair (HP:0009888)2.34495081
61Abnormality of the axillary hair (HP:0100134)2.34495081
62Type II lissencephaly (HP:0007260)2.33288572
63* Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.31669257
64Male pseudohermaphroditism (HP:0000037)2.31454549
65Hyperglycinemia (HP:0002154)2.31402880
66Tubular atrophy (HP:0000092)2.31370902
67Absent phalangeal crease (HP:0006109)2.30893096
68Pendular nystagmus (HP:0012043)2.30081504
69Abnormality of incisor morphology (HP:0011063)2.29259742
70Furrowed tongue (HP:0000221)2.29165867
71Congenital primary aphakia (HP:0007707)2.28586396
72Thyroid carcinoma (HP:0002890)2.26550254
73Abnormal rod and cone electroretinograms (HP:0008323)2.25094040
74* Abnormality of the proximal phalanges of the hand (HP:0009834)2.24115982
75Hemiparesis (HP:0001269)2.22333389
76Decreased central vision (HP:0007663)2.22297446
77Abnormality of the distal phalanges of the toes (HP:0010182)2.22193554
78Increased corneal curvature (HP:0100692)2.21952236
79Keratoconus (HP:0000563)2.21952236
80Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.21823368
81Gaze-evoked nystagmus (HP:0000640)2.20916622
82Genital tract atresia (HP:0001827)2.18870664
83Optic nerve hypoplasia (HP:0000609)2.17755607
84Anencephaly (HP:0002323)2.17088105
85Hyperventilation (HP:0002883)2.16081158
86Absent rod-and cone-mediated responses on ERG (HP:0007688)2.16069619
87Broad-based gait (HP:0002136)2.14891858
88Nephrogenic diabetes insipidus (HP:0009806)2.14864960
89Genetic anticipation (HP:0003743)2.12766759
90Chorioretinal atrophy (HP:0000533)2.11990329
91Vaginal atresia (HP:0000148)2.11789889
92Hemiplegia (HP:0002301)2.10864721
93Abnormal drinking behavior (HP:0030082)2.08894879
94Polydipsia (HP:0001959)2.08894879
95Congenital hepatic fibrosis (HP:0002612)2.07584425
96Male infertility (HP:0003251)2.07025403
97Septo-optic dysplasia (HP:0100842)2.06644321
98Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.06462253
99Febrile seizures (HP:0002373)2.05491645
100Rhinitis (HP:0012384)2.04485845
101Abnormality of the 4th metacarpal (HP:0010012)2.04256485
102* Tarsal synostosis (HP:0008368)2.03318942
103* Symphalangism affecting the phalanges of the hand (HP:0009773)2.02779048
104Action tremor (HP:0002345)2.01548934
105Occipital encephalocele (HP:0002085)1.98842290
106Myokymia (HP:0002411)1.98586522
107Focal seizures (HP:0007359)1.98187577
108Supernumerary spleens (HP:0009799)1.95434837
109Bifid scrotum (HP:0000048)1.94103615
110Attenuation of retinal blood vessels (HP:0007843)1.93005275
111* Postaxial hand polydactyly (HP:0001162)1.92791049
112Onycholysis (HP:0001806)1.92001242
113* Synostosis involving bones of the lower limbs (HP:0009138)1.91836662
114* Synostosis involving bones of the feet (HP:0009140)1.91836662
115Specific learning disability (HP:0001328)1.90781081
116Abnormality of the columella (HP:0009929)1.90641794
117* Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.89791467
118Coronal craniosynostosis (HP:0004440)1.88838155
119Bronchomalacia (HP:0002780)1.87576364
120Small hand (HP:0200055)1.87465151
121Bony spicule pigmentary retinopathy (HP:0007737)1.87294173
122Acute necrotizing encephalopathy (HP:0006965)1.86599687
123Back pain (HP:0003418)1.86487358
124Neurofibrillary tangles (HP:0002185)1.86443968
125Renal cortical cysts (HP:0000803)1.85682056
126Abnormality of binocular vision (HP:0011514)1.85414143
127Diplopia (HP:0000651)1.85414143
128Progressive macrocephaly (HP:0004481)1.84323665
129Preaxial hand polydactyly (HP:0001177)1.82762742
130* Abnormality of the middle phalanges of the hand (HP:0009833)1.81236646
131Anophthalmia (HP:0000528)1.80494430
132Epileptic encephalopathy (HP:0200134)1.80254454
133Decreased electroretinogram (ERG) amplitude (HP:0000654)1.78939717
134Generalized tonic-clonic seizures (HP:0002069)1.78812188
135Hypoplastic scapulae (HP:0000882)1.78792047
136Aplasia/Hypoplasia of the scapulae (HP:0006713)1.78792047
137Cubitus valgus (HP:0002967)1.77446265
138Renal dysplasia (HP:0000110)1.76880397
139Progressive cerebellar ataxia (HP:0002073)1.76211394
140Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.74800908
141Methylmalonic aciduria (HP:0012120)1.73919303
142Broad thumb (HP:0011304)1.73509950
143Intestinal atresia (HP:0011100)1.72464473
144* Synostosis of carpal bones (HP:0005048)1.72019824
145Mitochondrial inheritance (HP:0001427)1.71283571
146Median cleft lip (HP:0000161)1.68605389
147Adrenal hypoplasia (HP:0000835)1.68556061
148Stomach cancer (HP:0012126)1.67464619
149Polyuria (HP:0000103)1.67409584
150Exocrine pancreatic insufficiency (HP:0001738)1.67102715
151* Abnormality of the phalanges of the 5th finger (HP:0004213)1.67053631
152Short 4th metacarpal (HP:0010044)1.66762706
153Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.66762706
154Abnormality of glycine metabolism (HP:0010895)1.66385022
155Abnormality of serine family amino acid metabolism (HP:0010894)1.66385022
156Mixed hearing impairment (HP:0000410)1.65735066
157Infantile muscular hypotonia (HP:0008947)1.65182997
158Clumsiness (HP:0002312)1.63172226
159Shawl scrotum (HP:0000049)1.62994085
160Abnormality of the dental pulp (HP:0006479)1.62350844
161Arterial tortuosity (HP:0005116)1.60915163
162Absent hair (HP:0002298)1.60571895
163Short humerus (HP:0005792)1.59941099
164Fibular hypoplasia (HP:0003038)1.58666327
165Urinary bladder sphincter dysfunction (HP:0002839)1.58248271
166Microglossia (HP:0000171)1.58121489
167Spinal canal stenosis (HP:0003416)1.57266294
168Cerebral inclusion bodies (HP:0100314)1.56847821
169Abnormality of the dental root (HP:0006486)1.55313392
170Taurodontia (HP:0000679)1.55313392
171Abnormality of permanent molar morphology (HP:0011071)1.55313392
172Dysdiadochokinesis (HP:0002075)1.55108156
173Intention tremor (HP:0002080)1.54381416
174Short middle phalanx of the 5th finger (HP:0004220)1.54264155
175Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.53529584
176Shallow orbits (HP:0000586)1.53146500
177Neonatal short-limb short stature (HP:0008921)1.52938551
178Hypoplastic toenails (HP:0001800)1.49164508
179Status epilepticus (HP:0002133)1.49051745
180Enlarged penis (HP:0000040)1.48614724
181Abnormality of the diencephalon (HP:0010662)1.47827048
182Congenital sensorineural hearing impairment (HP:0008527)1.46117741
183Abnormality of the costochondral junction (HP:0000919)1.43830087

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.60727693
2STK393.21278208
3EPHA43.19430169
4LMTK23.14133673
5MAP4K22.84562535
6PRKD32.66434972
7AKT32.56639100
8WNK32.48195254
9OXSR12.45369754
10GRK12.41198236
11PHKG22.22561883
12PHKG12.22561883
13LATS22.21720116
14NTRK32.17754906
15ADRBK22.11622202
16ACVR1B2.11033260
17NTRK22.09839712
18CASK2.03137264
19TRIB32.00807721
20FRK2.00151257
21TAOK31.96352770
22TLK11.94027944
23MAP3K41.89918640
24TNIK1.87083121
25ZAK1.85407884
26WNK41.83570262
27SGK21.77957602
28MAP3K91.65857431
29PNCK1.59297801
30MUSK1.54624816
31STK38L1.51117229
32BMPR21.47412487
33MAP2K71.45599120
34DMPK1.45381102
35SGK4941.40749259
36SGK2231.40749259
37SGK31.37899946
38INSRR1.37248744
39MAPK151.31852561
40MAP3K21.30684354
41MAPK131.29856214
42SIK11.29418134
43DYRK21.28000046
44ERBB41.27720508
45STK381.22370672
46MST41.19266280
47TAOK11.18087246
48NTRK11.04983088
49NEK61.04203367
50FER1.04151085
51TGFBR11.03981388
52MKNK21.03969573
53KSR21.01935927
54CSNK1G11.00608622
55NUAK10.99997217
56BCKDK0.99625491
57CAMKK10.98398152
58GRK50.95515542
59MINK10.94500498
60STK160.93627230
61PKN10.92939412
62MAP2K40.91761260
63WEE10.91592004
64PAK60.90689377
65CSNK1G30.88878930
66GRK70.88657103
67VRK10.87418059
68CSNK1A1L0.86970174
69PRPF4B0.85516865
70TIE10.84035088
71PLK40.83132719
72TYRO30.82273520
73MOS0.82047970
74PAK30.81609842
75ERBB30.81205723
76ROCK10.80215497
77PINK10.79034606
78DAPK20.78295164
79PIK3CA0.78032601
80TNK20.76213727
81MARK10.75064794
82EPHB20.73852242
83MAP3K60.69179128
84ADRBK10.68755500
85PDGFRA0.67991815
86CAMK2A0.67812408
87CDK50.67251657
88RET0.66844709
89EEF2K0.66229411
90PLK30.65386107
91STK30.64430927
92DDR20.63790590
93PRKACA0.62435424
94PLK20.62214466
95CSNK1A10.61270081
96SGK10.61186695
97CDK30.60983074
98ROCK20.60929720
99CSNK1G20.58906691
100KSR10.58452849
101MAPKAPK50.58001616
102TXK0.56241505
103CAMKK20.54990679
104PIK3CG0.53622561
105BRSK20.51843245
106CDC42BPA0.51370171
107PRKD20.49505113
108PRKCE0.49332808
109MAP2K10.49084248
110BMPR1B0.47857763
111PRKCH0.47840299
112ERN10.47705431
113FGFR20.47682959
114ERBB20.46996481
115TAF10.45896706
116PRKCG0.45654483
117EIF2AK30.44561246
118MKNK10.43965216
119PRKAA10.43401917
120CDK90.42990922
121EIF2AK20.42850175
122TRIM280.41842022
123PTK20.41357361
124OBSCN0.41218356
125CDK80.41053837
126PRKCI0.40386411
127IRAK10.40006239
128CCNB10.39893022
129PRKG10.39551797
130STK110.39451602
131MAPKAPK30.38631228
132PLK10.38460782
133RIPK10.38358124
134STK100.38091739
135RPS6KA30.37816674
136PDPK10.37602887
137PTK2B0.37537601
138RPS6KA50.36826746
139BCR0.36678243
140EIF2AK10.36550125
141DYRK1A0.35641000
142PRKCA0.35573891
143PDK20.34947835
144CAMK2G0.34773943
145PRKCQ0.34761780
146BRAF0.33702033
147MARK20.32098594
148WNK10.31103155
149LRRK20.30377054
150MAP3K70.30047449
151PDGFRB0.29751395

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.26666363
2Caffeine metabolism_Homo sapiens_hsa002323.06024461
3Phototransduction_Homo sapiens_hsa047442.42373133
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.40946345
5Fatty acid biosynthesis_Homo sapiens_hsa000612.32102983
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.18738856
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.12938102
8Circadian rhythm_Homo sapiens_hsa047102.05309527
9Nicotine addiction_Homo sapiens_hsa050332.02207808
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.01093481
11Salivary secretion_Homo sapiens_hsa049701.99680529
12Oxidative phosphorylation_Homo sapiens_hsa001901.91877418
13Gastric acid secretion_Homo sapiens_hsa049711.82746118
14Glutamatergic synapse_Homo sapiens_hsa047241.81902167
15Protein export_Homo sapiens_hsa030601.77133542
16Sulfur metabolism_Homo sapiens_hsa009201.77112896
17Linoleic acid metabolism_Homo sapiens_hsa005911.77028561
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.64572370
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.63665765
20GABAergic synapse_Homo sapiens_hsa047271.63110782
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.61682551
22Insulin secretion_Homo sapiens_hsa049111.59861107
23Propanoate metabolism_Homo sapiens_hsa006401.56877602
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54212056
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.53598052
26Chemical carcinogenesis_Homo sapiens_hsa052041.52929456
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.51924511
28Tryptophan metabolism_Homo sapiens_hsa003801.51232435
29Circadian entrainment_Homo sapiens_hsa047131.50933728
30Butanoate metabolism_Homo sapiens_hsa006501.48886923
31Parkinsons disease_Homo sapiens_hsa050121.45457408
32Cocaine addiction_Homo sapiens_hsa050301.42774533
33Retinol metabolism_Homo sapiens_hsa008301.41152347
34Cardiac muscle contraction_Homo sapiens_hsa042601.41053451
35Amphetamine addiction_Homo sapiens_hsa050311.39572767
36Basal transcription factors_Homo sapiens_hsa030221.38977025
37Dorso-ventral axis formation_Homo sapiens_hsa043201.38041703
38Synaptic vesicle cycle_Homo sapiens_hsa047211.37639171
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.36667110
40Olfactory transduction_Homo sapiens_hsa047401.36140359
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.35742219
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.35469135
43Fanconi anemia pathway_Homo sapiens_hsa034601.32811883
44Pancreatic secretion_Homo sapiens_hsa049721.32480495
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.32179855
46Ovarian steroidogenesis_Homo sapiens_hsa049131.32139676
47Long-term potentiation_Homo sapiens_hsa047201.31909907
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29420527
49Homologous recombination_Homo sapiens_hsa034401.28891402
50Thyroid hormone synthesis_Homo sapiens_hsa049181.27841718
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.24711036
52Cholinergic synapse_Homo sapiens_hsa047251.23198386
53RNA degradation_Homo sapiens_hsa030181.21002039
54Renin secretion_Homo sapiens_hsa049241.19450375
55Primary bile acid biosynthesis_Homo sapiens_hsa001201.18684257
56Mineral absorption_Homo sapiens_hsa049781.18190139
57cAMP signaling pathway_Homo sapiens_hsa040241.18007606
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.17743367
59Morphine addiction_Homo sapiens_hsa050321.15907207
60Steroid hormone biosynthesis_Homo sapiens_hsa001401.15148419
61Dopaminergic synapse_Homo sapiens_hsa047281.15055822
62Calcium signaling pathway_Homo sapiens_hsa040201.12732847
63Alzheimers disease_Homo sapiens_hsa050101.10995010
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.10910106
65GnRH signaling pathway_Homo sapiens_hsa049121.09615909
66Huntingtons disease_Homo sapiens_hsa050161.07542603
67beta-Alanine metabolism_Homo sapiens_hsa004101.06954538
68Ether lipid metabolism_Homo sapiens_hsa005651.05690115
69Long-term depression_Homo sapiens_hsa047301.02947127
70Steroid biosynthesis_Homo sapiens_hsa001001.01407831
71Melanogenesis_Homo sapiens_hsa049161.01380503
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00071147
73Gap junction_Homo sapiens_hsa045400.98951116
74Tight junction_Homo sapiens_hsa045300.96649628
75Peroxisome_Homo sapiens_hsa041460.96632204
76* Hippo signaling pathway_Homo sapiens_hsa043900.96217247
77Oxytocin signaling pathway_Homo sapiens_hsa049210.95236234
78Histidine metabolism_Homo sapiens_hsa003400.95209922
79Choline metabolism in cancer_Homo sapiens_hsa052310.93256296
80Estrogen signaling pathway_Homo sapiens_hsa049150.93239382
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91344506
82Bile secretion_Homo sapiens_hsa049760.90425957
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89914749
84Adherens junction_Homo sapiens_hsa045200.89810400
85Endometrial cancer_Homo sapiens_hsa052130.88494847
86Basal cell carcinoma_Homo sapiens_hsa052170.88141704
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87715942
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87601359
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87472778
90Serotonergic synapse_Homo sapiens_hsa047260.87092872
91ErbB signaling pathway_Homo sapiens_hsa040120.84662561
92Glioma_Homo sapiens_hsa052140.83669286
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83341963
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.83122996
95Wnt signaling pathway_Homo sapiens_hsa043100.82988556
96Dilated cardiomyopathy_Homo sapiens_hsa054140.80386962
97Vibrio cholerae infection_Homo sapiens_hsa051100.80133224
98* TGF-beta signaling pathway_Homo sapiens_hsa043500.79453669
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77649956
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77067359
101Intestinal immune network for IgA production_Homo sapiens_hsa046720.76963306
102Glycerolipid metabolism_Homo sapiens_hsa005610.75672695
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74759417
104Taste transduction_Homo sapiens_hsa047420.72774065
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71886235
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.71507876
107Regulation of autophagy_Homo sapiens_hsa041400.71356246
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70821609
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69983196
110ABC transporters_Homo sapiens_hsa020100.69257558
111Axon guidance_Homo sapiens_hsa043600.69179377
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69163314
113Melanoma_Homo sapiens_hsa052180.68388873
114RNA polymerase_Homo sapiens_hsa030200.68063604
115Prostate cancer_Homo sapiens_hsa052150.67871078
116Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67815961
117Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66858037
118Rap1 signaling pathway_Homo sapiens_hsa040150.66416875
119Arachidonic acid metabolism_Homo sapiens_hsa005900.66253135
120Fatty acid metabolism_Homo sapiens_hsa012120.65028139
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64696657
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64606636
123Hedgehog signaling pathway_Homo sapiens_hsa043400.64407404
124Renin-angiotensin system_Homo sapiens_hsa046140.62178644
125Collecting duct acid secretion_Homo sapiens_hsa049660.61349198
126* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60193778
127Protein digestion and absorption_Homo sapiens_hsa049740.60147281
128mTOR signaling pathway_Homo sapiens_hsa041500.58816247
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58139198
130Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57913563
131Proteoglycans in cancer_Homo sapiens_hsa052050.57375164
132Focal adhesion_Homo sapiens_hsa045100.55751456
133Pancreatic cancer_Homo sapiens_hsa052120.55582779
134Inositol phosphate metabolism_Homo sapiens_hsa005620.55051283
135Glucagon signaling pathway_Homo sapiens_hsa049220.53991683
136Selenocompound metabolism_Homo sapiens_hsa004500.53371642
137Ras signaling pathway_Homo sapiens_hsa040140.52813099
138Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52003325
139Asthma_Homo sapiens_hsa053100.51581624
140N-Glycan biosynthesis_Homo sapiens_hsa005100.50297012
141Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47625722
142Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47613714
143Vitamin digestion and absorption_Homo sapiens_hsa049770.46980122
144Oocyte meiosis_Homo sapiens_hsa041140.46866983
145Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46447609
146Type II diabetes mellitus_Homo sapiens_hsa049300.46041978
147Adipocytokine signaling pathway_Homo sapiens_hsa049200.45160126
148Tyrosine metabolism_Homo sapiens_hsa003500.43225776
149Fatty acid degradation_Homo sapiens_hsa000710.42764043
150Metabolic pathways_Homo sapiens_hsa011000.41018995
151Alcoholism_Homo sapiens_hsa050340.38504989
152* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37125305

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