ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	4.11813821
2	positive regulation of mitochondrial fission (GO:0090141)	4.02404698
3	nucleobase catabolic process (GO:0046113)	3.66034804
4	peptidyl-cysteine modification (GO:0018198)	3.45333036
5	presynaptic membrane assembly (GO:0097105)	3.44456642
6	water-soluble vitamin biosynthetic process (GO:0042364)	3.27999733
7	intraciliary transport (GO:0042073)	3.17727119
8	cullin deneddylation (GO:0010388)	3.16936092
9	nonmotile primary cilium assembly (GO:0035058)	3.12637357
10	protein complex biogenesis (GO:0070271)	3.08211524
11	glycosphingolipid biosynthetic process (GO:0006688)	3.07755144
12	regulation of cilium movement (GO:0003352)	3.04738824
13	DNA double-strand break processing (GO:0000729)	3.04584060
14	respiratory chain complex IV assembly (GO:0008535)	3.03406826
15	presynaptic membrane organization (GO:0097090)	3.00776437
16	cilium morphogenesis (GO:0060271)	2.99001306
17	cholesterol biosynthetic process (GO:0006695)	2.91919621
18	coenzyme catabolic process (GO:0009109)	2.84665405
19	sterol biosynthetic process (GO:0016126)	2.83101788
20	protein polyglutamylation (GO:0018095)	2.82843406
21	organelle disassembly (GO:1903008)	2.80767640
22	protein deneddylation (GO:0000338)	2.80716869
23	ribonucleoprotein complex disassembly (GO:0032988)	2.80164001
24	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.80079533
25	NADH dehydrogenase complex assembly (GO:0010257)	2.80079533
26	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.80079533
27	mitochondrial respiratory chain complex assembly (GO:0033108)	2.78574981
28	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.76233412
29	substrate-independent telencephalic tangential migration (GO:0021826)	2.76233412
30	axoneme assembly (GO:0035082)	2.73560509
31	platelet dense granule organization (GO:0060155)	2.73187648
32	dendritic spine morphogenesis (GO:0060997)	2.73095914
33	behavioral response to nicotine (GO:0035095)	2.70664795
34	magnesium ion transport (GO:0015693)	2.70501357
35	establishment of melanosome localization (GO:0032401)	2.69139673
36	melanosome transport (GO:0032402)	2.67014484
37	neuron cell-cell adhesion (GO:0007158)	2.66670594
38	axonal fasciculation (GO:0007413)	2.65085366
39	gamma-aminobutyric acid transport (GO:0015812)	2.64259641
40	protein-cofactor linkage (GO:0018065)	2.64086057
41	protein neddylation (GO:0045116)	2.62077341
42	postsynaptic membrane organization (GO:0001941)	2.60644304
43	cilium assembly (GO:0042384)	2.59802754
44	cilium organization (GO:0044782)	2.58710951
45	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.57020074
46	vocalization behavior (GO:0071625)	2.56839311
47	protein localization to cilium (GO:0061512)	2.55792146
48	epithelial cilium movement (GO:0003351)	2.55738085
49	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.54505521
50	regulation of mitochondrial fission (GO:0090140)	2.53932043
51	neuronal action potential propagation (GO:0019227)	2.50223220
52	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.49956347
53	establishment of pigment granule localization (GO:0051905)	2.49888518
54	lactate metabolic process (GO:0006089)	2.49075507
55	synapse assembly (GO:0007416)	2.47001018
56	pigment granule transport (GO:0051904)	2.46984876
57	peroxisome fission (GO:0016559)	2.46141341
58	regulation of hexokinase activity (GO:1903299)	2.45476305
59	regulation of glucokinase activity (GO:0033131)	2.45476305
60	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.42994122
61	melanosome localization (GO:0032400)	2.42661707
62	cytochrome complex assembly (GO:0017004)	2.41770007
63	lipid particle organization (GO:0034389)	2.38145491
64	isoprenoid biosynthetic process (GO:0008299)	2.38064241
65	kidney morphogenesis (GO:0060993)	2.37752458
66	histone H2A acetylation (GO:0043968)	2.36837300
67	cornea development in camera-type eye (GO:0061303)	2.36350590
68	protein localization to Golgi apparatus (GO:0034067)	2.34864285
69	protein targeting to Golgi (GO:0000042)	2.34778376
70	brain morphogenesis (GO:0048854)	2.34156638
71	response to pheromone (GO:0019236)	2.33731959
72	peptidyl-histidine modification (GO:0018202)	2.32890142
73	retinal ganglion cell axon guidance (GO:0031290)	2.32379228
74	neuron recognition (GO:0008038)	2.31262606
75	regulation of microtubule-based movement (GO:0060632)	2.30051199
76	establishment of protein localization to Golgi (GO:0072600)	2.27394838
77	retinal cone cell development (GO:0046549)	2.26227764
78	pigment granule localization (GO:0051875)	2.26009763
79	neural tube formation (GO:0001841)	2.25187562
80	intra-Golgi vesicle-mediated transport (GO:0006891)	2.24519449
81	establishment of mitochondrion localization (GO:0051654)	2.23557081
82	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.22547749
83	regulation of action potential (GO:0098900)	2.22271863
84	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.22058835
85	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.20151091
86	acrosome reaction (GO:0007340)	2.19418067
87	negative regulation of JAK-STAT cascade (GO:0046426)	2.19283422
88	GPI anchor metabolic process (GO:0006505)	2.19167251
89	C-terminal protein amino acid modification (GO:0018410)	2.18910559
90	insulin secretion (GO:0030073)	2.18264568
91	DNA damage response, detection of DNA damage (GO:0042769)	2.18202709
92	righting reflex (GO:0060013)	2.18055262
93	mannosylation (GO:0097502)	2.16070175
94	preassembly of GPI anchor in ER membrane (GO:0016254)	2.15247493
95	C-terminal protein lipidation (GO:0006501)	2.14940773
96	glycolipid biosynthetic process (GO:0009247)	2.13964219
97	glycerophospholipid catabolic process (GO:0046475)	2.12986313
98	xenobiotic catabolic process (GO:0042178)	2.11732931
99	cellular component assembly involved in morphogenesis (GO:0010927)	2.10023874
100	cellular ketone body metabolic process (GO:0046950)	2.09173982

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.59910158
2	ZNF274_21170338_ChIP-Seq_K562_Hela	2.88628559
3	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.86340446
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.77325157
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.76286127
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.74944115
7	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.72168852
8	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.44467473
9	VDR_22108803_ChIP-Seq_LS180_Human	2.33329029
10	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.32513916
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.27026161
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.19477293
13	P300_19829295_ChIP-Seq_ESCs_Human	2.18052744
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.15279173
15	FUS_26573619_Chip-Seq_HEK293_Human	2.10249647
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.99153351
17	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.96443475
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.96036240
19	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.91644857
20	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.87102457
21	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.86931369
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.85663778
23	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.81962850
24	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.80389441
25	ELK1_19687146_ChIP-ChIP_HELA_Human	1.76857407
26	EWS_26573619_Chip-Seq_HEK293_Human	1.73594042
27	SMAD4_21799915_ChIP-Seq_A2780_Human	1.73355190
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.72638622
29	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.72376751
30	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.65396061
31	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.65161440
32	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.57845128
33	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.57523098
34	ER_23166858_ChIP-Seq_MCF-7_Human	1.56412734
35	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.53860671
36	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.52856960
37	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.49470991
38	CBP_20019798_ChIP-Seq_JUKART_Human	1.49470991
39	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.45048771
40	AR_25329375_ChIP-Seq_VCAP_Human	1.44537838
41	EZH2_22144423_ChIP-Seq_EOC_Human	1.44084008
42	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.43406311
43	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.42598775
44	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.42084607
45	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.40535721
46	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.36042348
47	STAT3_23295773_ChIP-Seq_U87_Human	1.35967514
48	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.34349206
49	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.33863464
50	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.31392917
51	RNF2_27304074_Chip-Seq_NSC_Mouse	1.29034335
52	BCAT_22108803_ChIP-Seq_LS180_Human	1.28321840
53	TP53_22573176_ChIP-Seq_HFKS_Human	1.28126879
54	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.27739286
55	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.27288707
56	REST_21632747_ChIP-Seq_MESCs_Mouse	1.26745134
57	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.26174572
58	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.24403112
59	TCF4_23295773_ChIP-Seq_U87_Human	1.24362774
60	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.23749343
61	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.23229953
62	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.23167063
63	IRF1_19129219_ChIP-ChIP_H3396_Human	1.22483311
64	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.22138550
65	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.21647436
66	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.20181319
67	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.19764789
68	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.18766716
69	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.16551050
70	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.15105722
71	RUNX2_22187159_ChIP-Seq_PCA_Human	1.14574568
72	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.13129088
73	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.11821606
74	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.10566162
75	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.10094416
76	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.10025881
77	NANOG_19829295_ChIP-Seq_ESCs_Human	1.09920535
78	SOX2_19829295_ChIP-Seq_ESCs_Human	1.09920535
79	TCF4_22108803_ChIP-Seq_LS180_Human	1.08303904
80	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.08092525
81	TP53_18474530_ChIP-ChIP_U2OS_Human	1.06735012
82	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.05795947
83	P53_22387025_ChIP-Seq_ESCs_Mouse	1.05405462
84	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.03017053
85	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.02559661
86	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.97936478
87	JUN_21703547_ChIP-Seq_K562_Human	0.97016741
88	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.96671875
89	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.96426888
90	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.95854308
91	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.95330935
92	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.95189995
93	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.95181975
94	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.95181975
95	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.93936929
96	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.93786677
97	P300_18555785_Chip-Seq_ESCs_Mouse	0.93224292
98	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.92276269
99	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.91718606
100	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.91322492

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003122_maternal_imprinting	3.34473219
2	MP0001984_abnormal_olfaction	2.90998363
3	MP0003787_abnormal_imprinting	2.56564477
4	MP0001529_abnormal_vocalization	2.44919745
5	MP0003121_genomic_imprinting	2.43711818
6	MP0009780_abnormal_chondrocyte_physiolo	2.30996975
7	MP0002102_abnormal_ear_morphology	2.27719980
8	MP0004147_increased_porphyrin_level	2.25430443
9	MP0002837_dystrophic_cardiac_calcinosis	2.18159701
10	MP0003880_abnormal_central_pattern	2.01406956
11	MP0004270_analgesia	2.00314358
12	MP0008877_abnormal_DNA_methylation	1.94959643
13	MP0005084_abnormal_gallbladder_morpholo	1.90428188
14	MP0002909_abnormal_adrenal_gland	1.82107328
15	MP0003195_calcinosis	1.80239565
16	MP0006072_abnormal_retinal_apoptosis	1.79529149
17	MP0009046_muscle_twitch	1.78143183
18	MP0005645_abnormal_hypothalamus_physiol	1.75925817
19	MP0002653_abnormal_ependyma_morphology	1.72215884
20	MP0000013_abnormal_adipose_tissue	1.64168869
21	MP0006054_spinal_hemorrhage	1.63997532
22	MP0008789_abnormal_olfactory_epithelium	1.63591126
23	MP0006276_abnormal_autonomic_nervous	1.63475237
24	MP0003011_delayed_dark_adaptation	1.56083104
25	MP0005379_endocrine/exocrine_gland_phen	1.55053336
26	MP0005499_abnormal_olfactory_system	1.52081930
27	MP0005394_taste/olfaction_phenotype	1.52081930
28	MP0004859_abnormal_synaptic_plasticity	1.51685101
29	MP0004133_heterotaxia	1.49505460
30	MP0004142_abnormal_muscle_tone	1.46231383
31	MP0002272_abnormal_nervous_system	1.44451547
32	MP0005551_abnormal_eye_electrophysiolog	1.43912291
33	MP0002163_abnormal_gland_morphology	1.42508738
34	MP0005253_abnormal_eye_physiology	1.41349989
35	MP0002557_abnormal_social/conspecific_i	1.39359578
36	MP0000778_abnormal_nervous_system	1.38970144
37	MP0002938_white_spotting	1.38546587
38	MP0001486_abnormal_startle_reflex	1.33120512
39	MP0001299_abnormal_eye_distance/	1.31565060
40	MP0002572_abnormal_emotion/affect_behav	1.29399272
41	MP0002734_abnormal_mechanical_nocicepti	1.27403357
42	MP0009745_abnormal_behavioral_response	1.27138849
43	MP0002234_abnormal_pharynx_morphology	1.26037813
44	MP0004215_abnormal_myocardial_fiber	1.25373188
45	MP0008775_abnormal_heart_ventricle	1.20235858
46	MP0002751_abnormal_autonomic_nervous	1.19411618
47	MP0010386_abnormal_urinary_bladder	1.18332095
48	MP0003635_abnormal_synaptic_transmissio	1.17122261
49	MP0002876_abnormal_thyroid_physiology	1.15938657
50	MP0002063_abnormal_learning/memory/cond	1.13493192
51	MP0002295_abnormal_pulmonary_circulatio	1.12596338
52	MP0006292_abnormal_olfactory_placode	1.12251743
53	MP0002233_abnormal_nose_morphology	1.11908707
54	MP0005187_abnormal_penis_morphology	1.11335546
55	MP0000647_abnormal_sebaceous_gland	1.10712575
56	MP0002184_abnormal_innervation	1.08270801
57	MP0001968_abnormal_touch/_nociception	1.05478555
58	MP0003119_abnormal_digestive_system	1.04025603
59	MP0002928_abnormal_bile_duct	1.02779740
60	MP0001970_abnormal_pain_threshold	1.02484348
61	MP0002638_abnormal_pupillary_reflex	1.02056504
62	MP0006035_abnormal_mitochondrial_morpho	0.96298907
63	MP0005386_behavior/neurological_phenoty	0.95892298
64	MP0004924_abnormal_behavior	0.95892298
65	MP0001293_anophthalmia	0.95654770
66	MP0002090_abnormal_vision	0.95124530
67	MP0000631_abnormal_neuroendocrine_gland	0.94858065
68	MP0002736_abnormal_nociception_after	0.93316896
69	MP0004811_abnormal_neuron_physiology	0.93126408
70	MP0002067_abnormal_sensory_capabilities	0.92207052
71	MP0004085_abnormal_heartbeat	0.90356446
72	MP0004272_abnormal_basement_membrane	0.90307351
73	MP0005623_abnormal_meninges_morphology	0.88311727
74	MP0002064_seizures	0.86078996
75	MP0000569_abnormal_digit_pigmentation	0.85840665
76	MP0005248_abnormal_Harderian_gland	0.85817175
77	MP0003890_abnormal_embryonic-extraembry	0.85437872
78	MP0003937_abnormal_limbs/digits/tail_de	0.85298368
79	MP0004043_abnormal_pH_regulation	0.84757871
80	MP0000749_muscle_degeneration	0.84284645
81	MP0003123_paternal_imprinting	0.83801368
82	MP0005367_renal/urinary_system_phenotyp	0.83763125
83	MP0000516_abnormal_urinary_system	0.83763125
84	MP0010329_abnormal_lipoprotein_level	0.83379163
85	MP0002882_abnormal_neuron_morphology	0.83131443
86	MP0002752_abnormal_somatic_nervous	0.82924204
87	MP0005332_abnormal_amino_acid	0.82530016
88	MP0000955_abnormal_spinal_cord	0.82400900
89	MP0000358_abnormal_cell_content/	0.81019952
90	MP0001944_abnormal_pancreas_morphology	0.80986554
91	MP0003718_maternal_effect	0.79846233
92	MP0003950_abnormal_plasma_membrane	0.79704620
93	MP0001756_abnormal_urination	0.79655314
94	MP0000427_abnormal_hair_cycle	0.79635904
95	MP0002733_abnormal_thermal_nociception	0.78259425
96	MP0005195_abnormal_posterior_eye	0.77385521
97	MP0005646_abnormal_pituitary_gland	0.77022225
98	MP0003137_abnormal_impulse_conducting	0.76275133
99	MP0003755_abnormal_palate_morphology	0.76269211
100	MP0002069_abnormal_eating/drinking_beha	0.75577904

Predicted human phenotypes

Rank	Gene Set	Z-score
1	True hermaphroditism (HP:0010459)	3.36512220
2	Medial flaring of the eyebrow (HP:0010747)	3.24614784
3	Molar tooth sign on MRI (HP:0002419)	3.24009571
4	Abnormality of midbrain morphology (HP:0002418)	3.24009571
5	Pancreatic fibrosis (HP:0100732)	3.20613894
6	Pancreatic cysts (HP:0001737)	3.17466057
7	Abnormality of the labia minora (HP:0012880)	3.11477551
8	Gait imbalance (HP:0002141)	2.91715273
9	Nephronophthisis (HP:0000090)	2.90964914
10	Lissencephaly (HP:0001339)	2.88218003
11	Limb dystonia (HP:0002451)	2.85893009
12	Hypothermia (HP:0002045)	2.80352292
13	Intestinal atresia (HP:0011100)	2.77329412
14	Hypoglycemic coma (HP:0001325)	2.76032395
15	Methylmalonic acidemia (HP:0002912)	2.75700853
16	Polyphagia (HP:0002591)	2.73709857
17	Chronic hepatic failure (HP:0100626)	2.73656001
18	Congenital primary aphakia (HP:0007707)	2.73170429
19	Acute necrotizing encephalopathy (HP:0006965)	2.72528336
20	Poor suck (HP:0002033)	2.66966733
21	Nephrogenic diabetes insipidus (HP:0009806)	2.66240411
22	Hypsarrhythmia (HP:0002521)	2.63125359
23	EEG with generalized epileptiform discharges (HP:0011198)	2.61976969
24	Progressive macrocephaly (HP:0004481)	2.58094505
25	Hyperinsulinemic hypoglycemia (HP:0000825)	2.57065283
26	Renal cortical cysts (HP:0000803)	2.54504779
27	Epileptiform EEG discharges (HP:0011182)	2.54158719
28	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.44511928
29	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.44511928
30	Acute encephalopathy (HP:0006846)	2.42983129
31	Pachygyria (HP:0001302)	2.40920882
32	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.39755220
33	Hepatic necrosis (HP:0002605)	2.39372038
34	Abnormal mitochondria in muscle tissue (HP:0008316)	2.36820787
35	Hemiparesis (HP:0001269)	2.35426712
36	Delayed gross motor development (HP:0002194)	2.35006977
37	Abnormality of the renal medulla (HP:0100957)	2.34557257
38	Atonic seizures (HP:0010819)	2.33660769
39	Type II lissencephaly (HP:0007260)	2.31282095
40	Abnormality of the corticospinal tract (HP:0002492)	2.29673564
41	Methylmalonic aciduria (HP:0012120)	2.28324778
42	Genital tract atresia (HP:0001827)	2.25913191
43	Drooling (HP:0002307)	2.23251717
44	Mitochondrial inheritance (HP:0001427)	2.22595134
45	Abnormality of the metopic suture (HP:0005556)	2.20872625
46	Abnormality of the renal cortex (HP:0011035)	2.19832879
47	Sclerocornea (HP:0000647)	2.17225026
48	Exercise-induced muscle cramps (HP:0003710)	2.16056547
49	Vaginal atresia (HP:0000148)	2.15976716
50	Hepatocellular necrosis (HP:0001404)	2.14416596
51	Increased CSF lactate (HP:0002490)	2.13536006
52	Narrow forehead (HP:0000341)	2.09361459
53	Specific learning disability (HP:0001328)	2.07247232
54	Broad alveolar ridges (HP:0000187)	2.05493397
55	Hepatoblastoma (HP:0002884)	2.05101381
56	Short tibia (HP:0005736)	2.04953911
57	Postaxial hand polydactyly (HP:0001162)	2.04746370
58	Failure to thrive in infancy (HP:0001531)	2.04635438
59	3-Methylglutaconic aciduria (HP:0003535)	2.03249331
60	Large for gestational age (HP:0001520)	2.01590265
61	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.00887261
62	Cystic liver disease (HP:0006706)	1.98928749
63	Prominent metopic ridge (HP:0005487)	1.98124913
64	Muscular hypotonia of the trunk (HP:0008936)	1.94953958
65	Occipital encephalocele (HP:0002085)	1.94736000
66	Amyotrophic lateral sclerosis (HP:0007354)	1.93894124
67	Keratoconus (HP:0000563)	1.93597105
68	Increased corneal curvature (HP:0100692)	1.93597105
69	Termporal pattern (HP:0011008)	1.93131177
70	Insidious onset (HP:0003587)	1.93131177
71	Excessive salivation (HP:0003781)	1.92218318
72	Abnormality of vitamin B metabolism (HP:0004340)	1.91892158
73	Decreased muscle mass (HP:0003199)	1.90861909
74	Agitation (HP:0000713)	1.90300798
75	Broad-based gait (HP:0002136)	1.89988876
76	Hypoglycemic seizures (HP:0002173)	1.86659564
77	Proximal tubulopathy (HP:0000114)	1.86205206
78	Retinal dysplasia (HP:0007973)	1.85327443
79	Abnormal hair whorl (HP:0010721)	1.81367942
80	Ketoacidosis (HP:0001993)	1.79434594
81	Hip dysplasia (HP:0001385)	1.79263996
82	Spastic tetraplegia (HP:0002510)	1.77750792
83	Febrile seizures (HP:0002373)	1.77690008
84	Scrotal hypoplasia (HP:0000046)	1.76996066
85	Anencephaly (HP:0002323)	1.76784798
86	Cerebral edema (HP:0002181)	1.76340546
87	Aplasia/hypoplasia of the uterus (HP:0008684)	1.75771944
88	Disproportionate short-trunk short stature (HP:0003521)	1.74988928
89	Severe muscular hypotonia (HP:0006829)	1.74711713
90	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.74499914
91	Hypoplasia of the brainstem (HP:0002365)	1.74499914
92	Impaired vibration sensation in the lower limbs (HP:0002166)	1.72699784
93	Postaxial foot polydactyly (HP:0001830)	1.72651150
94	Congenital malformation of the right heart (HP:0011723)	1.72528077
95	Double outlet right ventricle (HP:0001719)	1.72528077
96	Progressive inability to walk (HP:0002505)	1.72159905
97	Dandy-Walker malformation (HP:0001305)	1.71270946
98	Hyperglycinemia (HP:0002154)	1.69710386
99	Adrenal hypoplasia (HP:0000835)	1.68212408
100	Optic nerve coloboma (HP:0000588)	1.68152579

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.72257601
2	FRK	3.42752561
3	BCR	3.16525066
4	TRIM28	3.14041075
5	MAP3K4	2.98412131
6	WNK3	2.59614360
7	ERBB3	2.41240034
8	CASK	2.38492192
9	MARK1	2.26678605
10	BMPR1B	2.21050719
11	MAP2K7	2.20521272
12	MAPK13	1.83480098
13	MKNK2	1.76817956
14	EPHA3	1.68686653
15	PAK3	1.66472779
16	PLK2	1.64553640
17	TNIK	1.58619828
18	PHKG2	1.57666569
19	PHKG1	1.57666569
20	PINK1	1.57549474
21	SIK3	1.54397971
22	CSNK1G2	1.52719461
23	GRK1	1.47786334
24	PRKD3	1.47262995
25	CSNK1G1	1.45193056
26	CSNK1G3	1.43451538
27	INSRR	1.43116800
28	BCKDK	1.40446574
29	EIF2AK3	1.39505402
30	TIE1	1.39264298
31	ADRBK2	1.36643290
32	LIMK1	1.30763702
33	DYRK2	1.29484146
34	PRKCE	1.27143627
35	CSNK1A1L	1.26654071
36	STK24	1.25933157
37	ACVR1B	1.24181031
38	STK38L	1.23819830
39	PRKCG	1.15950080
40	MAP3K12	1.09587210
41	FER	1.02122048
42	EIF2AK1	0.99557468
43	SRPK1	0.99277889
44	FLT3	0.98416524
45	PLK3	0.98104371
46	MINK1	0.94490531
47	STK39	0.91710542
48	WNK4	0.86423605
49	MST4	0.86016692
50	MKNK1	0.78864770
51	ERBB4	0.78846497
52	OXSR1	0.78012269
53	FGFR2	0.76431216
54	CAMK2A	0.75103171
55	PNCK	0.73453821
56	TSSK6	0.73434617
57	EPHA4	0.70758343
58	PTK2B	0.66208600
59	MAP2K4	0.65081596
60	NTRK2	0.64940890
61	MET	0.64585100
62	DYRK3	0.63593364
63	EPHB2	0.63128972
64	CAMK2D	0.62173523
65	RPS6KA4	0.59722741
66	CAMKK2	0.59651716
67	MUSK	0.59146763
68	PAK6	0.56560470
69	NUAK1	0.55514537
70	CDK8	0.54370739
71	TGFBR1	0.53669756
72	DAPK2	0.53649689
73	CDK14	0.50503345
74	ZAK	0.49338183
75	NEK1	0.48151988
76	ADRBK1	0.47930474
77	CAMK2B	0.47593429
78	OBSCN	0.46793372
79	PRKACB	0.44840545
80	STK16	0.44397519
81	TESK1	0.43725328
82	CDK18	0.42949683
83	PLK1	0.42692849
84	CSNK1A1	0.41921598
85	PKN2	0.41864346
86	STK3	0.41091235
87	BRSK2	0.41020280
88	CDK5	0.39377936
89	PRKACA	0.39219056
90	PRKCI	0.38733327
91	PRKG1	0.38695411
92	NTRK3	0.37907160
93	KSR1	0.37211184
94	DYRK1A	0.36310310
95	PRKAA1	0.36259076
96	BRD4	0.36013537
97	MYLK	0.35717701
98	CSNK1D	0.35551379
99	CDK19	0.35337233
100	UHMK1	0.35029925

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.79691719
2	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.65373799
3	Steroid biosynthesis_Homo sapiens_hsa00100	2.62824041
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.50817478
5	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.47556234
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.40125922
7	Propanoate metabolism_Homo sapiens_hsa00640	2.23035013
8	Butanoate metabolism_Homo sapiens_hsa00650	2.20657532
9	Oxidative phosphorylation_Homo sapiens_hsa00190	2.19194133
10	Fatty acid elongation_Homo sapiens_hsa00062	1.89276263
11	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.85270228
12	Parkinsons disease_Homo sapiens_hsa05012	1.83826519
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.81646451
14	Nicotine addiction_Homo sapiens_hsa05033	1.72514663
15	Basal transcription factors_Homo sapiens_hsa03022	1.54766899
16	Phototransduction_Homo sapiens_hsa04744	1.50240920
17	Folate biosynthesis_Homo sapiens_hsa00790	1.48019658
18	Sulfur metabolism_Homo sapiens_hsa00920	1.46254197
19	GABAergic synapse_Homo sapiens_hsa04727	1.43041034
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.37162008
21	Peroxisome_Homo sapiens_hsa04146	1.33769598
22	Collecting duct acid secretion_Homo sapiens_hsa04966	1.32838606
23	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.30386069
24	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.25327221
25	Selenocompound metabolism_Homo sapiens_hsa00450	1.24883353
26	RNA polymerase_Homo sapiens_hsa03020	1.19681613
27	Insulin secretion_Homo sapiens_hsa04911	1.19172686
28	Cardiac muscle contraction_Homo sapiens_hsa04260	1.16996670
29	Huntingtons disease_Homo sapiens_hsa05016	1.16181173
30	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.15078871
31	Alzheimers disease_Homo sapiens_hsa05010	1.13871127
32	beta-Alanine metabolism_Homo sapiens_hsa00410	1.11690546
33	Dopaminergic synapse_Homo sapiens_hsa04728	1.10963452
34	Vibrio cholerae infection_Homo sapiens_hsa05110	1.07315538
35	Circadian entrainment_Homo sapiens_hsa04713	1.00091348
36	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.98768833
37	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.97716607
38	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.97581980
39	Pyruvate metabolism_Homo sapiens_hsa00620	0.95604953
40	Circadian rhythm_Homo sapiens_hsa04710	0.95584695
41	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.94622002
42	Regulation of autophagy_Homo sapiens_hsa04140	0.92483704
43	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.92380308
44	Taste transduction_Homo sapiens_hsa04742	0.91746690
45	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.90252607
46	RNA degradation_Homo sapiens_hsa03018	0.89965688
47	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.89130634
48	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.88974151
49	Proteasome_Homo sapiens_hsa03050	0.86052506
50	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.84830764
51	Morphine addiction_Homo sapiens_hsa05032	0.84757175
52	Glutamatergic synapse_Homo sapiens_hsa04724	0.83894067
53	Ether lipid metabolism_Homo sapiens_hsa00565	0.82306837
54	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.81904442
55	Fatty acid metabolism_Homo sapiens_hsa01212	0.78229644
56	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.78211718
57	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.74908734
58	Metabolic pathways_Homo sapiens_hsa01100	0.74905740
59	Cocaine addiction_Homo sapiens_hsa05030	0.74896299
60	Glutathione metabolism_Homo sapiens_hsa00480	0.71610448
61	Arginine and proline metabolism_Homo sapiens_hsa00330	0.70681421
62	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.69665055
63	Oocyte meiosis_Homo sapiens_hsa04114	0.69647741
64	Tryptophan metabolism_Homo sapiens_hsa00380	0.68760009
65	Amphetamine addiction_Homo sapiens_hsa05031	0.68452472
66	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.66484421
67	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.65000465
68	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.64637847
69	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.63747051
70	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.62222657
71	Serotonergic synapse_Homo sapiens_hsa04726	0.62090090
72	Axon guidance_Homo sapiens_hsa04360	0.61566823
73	Retinol metabolism_Homo sapiens_hsa00830	0.61171705
74	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.61131979
75	Caffeine metabolism_Homo sapiens_hsa00232	0.61101728
76	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.60896097
77	Fanconi anemia pathway_Homo sapiens_hsa03460	0.60845791
78	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.60835790
79	Nitrogen metabolism_Homo sapiens_hsa00910	0.59862859
80	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.59721687
81	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.58935310
82	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.57647737
83	Hippo signaling pathway_Homo sapiens_hsa04390	0.57372476
84	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.54306001
85	Olfactory transduction_Homo sapiens_hsa04740	0.53976653
86	Non-homologous end-joining_Homo sapiens_hsa03450	0.52884283
87	Homologous recombination_Homo sapiens_hsa03440	0.52659799
88	Chemical carcinogenesis_Homo sapiens_hsa05204	0.52633354
89	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.51073314
90	Purine metabolism_Homo sapiens_hsa00230	0.50773934
91	Carbon metabolism_Homo sapiens_hsa01200	0.50386927
92	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.49785455
93	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.47184165
94	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.46795075
95	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.45489788
96	Tight junction_Homo sapiens_hsa04530	0.44813806
97	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.44805699
98	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.44278552
99	Pyrimidine metabolism_Homo sapiens_hsa00240	0.43998012
100	Linoleic acid metabolism_Homo sapiens_hsa00591	0.43255761

BMS1P10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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