ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of hexokinase activity (GO:1903299)	4.38938638
2	regulation of glucokinase activity (GO:0033131)	4.38938638
3	water-soluble vitamin biosynthetic process (GO:0042364)	4.06592613
4	protein localization to cilium (GO:0061512)	3.60428727
5	cellular ketone body metabolic process (GO:0046950)	3.52651666
6	respiratory chain complex IV assembly (GO:0008535)	3.50991372
7	negative regulation of execution phase of apoptosis (GO:1900118)	3.39099478
8	peptidyl-cysteine modification (GO:0018198)	3.36900373
9	response to pheromone (GO:0019236)	3.27042900
10	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.26170665
11	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	3.25151210
12	pyrimidine nucleobase catabolic process (GO:0006208)	3.19971286
13	intraciliary transport (GO:0042073)	3.16355061
14	nucleobase catabolic process (GO:0046113)	3.14294316
15	ketone body metabolic process (GO:1902224)	3.10270247
16	platelet dense granule organization (GO:0060155)	3.09432383
17	negative regulation of neurological system process (GO:0031645)	3.04596565
18	protein-cofactor linkage (GO:0018065)	3.03006523
19	glycerophospholipid catabolic process (GO:0046475)	3.02911422
20	cytochrome complex assembly (GO:0017004)	3.02811169
21	cullin deneddylation (GO:0010388)	3.01429418
22	response to redox state (GO:0051775)	3.00928301
23	coenzyme catabolic process (GO:0009109)	3.00550179
24	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	2.99683508
25	protein deneddylation (GO:0000338)	2.94076502
26	amino acid salvage (GO:0043102)	2.90717445
27	L-methionine salvage (GO:0071267)	2.90717445
28	L-methionine biosynthetic process (GO:0071265)	2.90717445
29	cilium morphogenesis (GO:0060271)	2.90155177
30	positive regulation of actin filament depolymerization (GO:0030836)	2.88855346
31	lactate metabolic process (GO:0006089)	2.86004055
32	C4-dicarboxylate transport (GO:0015740)	2.82702964
33	preassembly of GPI anchor in ER membrane (GO:0016254)	2.81917607
34	glycosphingolipid biosynthetic process (GO:0006688)	2.81477694
35	intra-Golgi vesicle-mediated transport (GO:0006891)	2.79930703
36	protein localization to Golgi apparatus (GO:0034067)	2.75587168
37	lipid particle organization (GO:0034389)	2.75536726
38	positive regulation of vesicle fusion (GO:0031340)	2.74533165
39	L-fucose catabolic process (GO:0042355)	2.74423498
40	fucose catabolic process (GO:0019317)	2.74423498
41	L-fucose metabolic process (GO:0042354)	2.74423498
42	positive regulation of mitochondrial fission (GO:0090141)	2.73480117
43	C-terminal protein lipidation (GO:0006501)	2.73252829
44	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	2.73154612
45	cornea development in camera-type eye (GO:0061303)	2.69852222
46	brain morphogenesis (GO:0048854)	2.69754494
47	nucleotide transmembrane transport (GO:1901679)	2.67978857
48	peroxisome fission (GO:0016559)	2.66838185
49	gamma-aminobutyric acid transport (GO:0015812)	2.65008691
50	detection of calcium ion (GO:0005513)	2.64830529
51	protein complex biogenesis (GO:0070271)	2.64615685
52	synaptic vesicle maturation (GO:0016188)	2.62721958
53	mannosylation (GO:0097502)	2.62199977
54	positive regulation of glycolytic process (GO:0045821)	2.60965775
55	protein K11-linked deubiquitination (GO:0035871)	2.60037050
56	cilium assembly (GO:0042384)	2.58732903
57	cilium organization (GO:0044782)	2.57959040
58	keratinocyte development (GO:0003334)	2.57122255
59	C-terminal protein amino acid modification (GO:0018410)	2.57009439
60	GPI anchor metabolic process (GO:0006505)	2.56644034
61	xenobiotic catabolic process (GO:0042178)	2.54831099
62	dicarboxylic acid catabolic process (GO:0043649)	2.50879531
63	establishment of protein localization to Golgi (GO:0072600)	2.50815761
64	response to lipoprotein particle (GO:0055094)	2.50460090
65	membrane budding (GO:0006900)	2.47050762
66	positive regulation of insulin secretion (GO:0032024)	2.45030734
67	protein targeting to Golgi (GO:0000042)	2.44294300
68	photoreceptor cell maintenance (GO:0045494)	2.43543468
69	negative regulation of telomere maintenance (GO:0032205)	2.43162794
70	vascular smooth muscle contraction (GO:0014829)	2.42858905
71	mitochondrial respiratory chain complex assembly (GO:0033108)	2.41944990
72	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.39984361
73	regulation of cilium movement (GO:0003352)	2.39445743
74	axoneme assembly (GO:0035082)	2.38477969
75	detection of light stimulus involved in visual perception (GO:0050908)	2.38129464
76	detection of light stimulus involved in sensory perception (GO:0050962)	2.38129464
77	branched-chain amino acid catabolic process (GO:0009083)	2.37388841
78	aldehyde catabolic process (GO:0046185)	2.37129875
79	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.36987821
80	peptidyl-histidine modification (GO:0018202)	2.36159954
81	signal peptide processing (GO:0006465)	2.34212671
82	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.33735028
83	positive regulation of peptide hormone secretion (GO:0090277)	2.33543249
84	response to nitrosative stress (GO:0051409)	2.32941842
85	pyrimidine dimer repair (GO:0006290)	2.32664087
86	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.32109145
87	negative regulation of membrane potential (GO:0045837)	2.29637025
88	cyclic nucleotide catabolic process (GO:0009214)	2.28228625
89	cAMP catabolic process (GO:0006198)	2.28010752
90	epithelial cilium movement (GO:0003351)	2.26680459
91	prenylation (GO:0097354)	2.26563155
92	protein prenylation (GO:0018342)	2.26563155
93	positive regulation of peptide secretion (GO:0002793)	2.26024813
94	dendritic spine morphogenesis (GO:0060997)	2.25754211
95	inositol phosphate catabolic process (GO:0071545)	2.25556328
96	glycolipid biosynthetic process (GO:0009247)	2.25115407
97	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.25011797
98	cholesterol biosynthetic process (GO:0006695)	2.24929025
99	protein neddylation (GO:0045116)	2.24901888
100	melanosome transport (GO:0032402)	2.23577431

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.21057834
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.17846836
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.95549598
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.93098335
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.83846330
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.76364032
7	VDR_22108803_ChIP-Seq_LS180_Human	2.55030219
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.50558917
9	FUS_26573619_Chip-Seq_HEK293_Human	2.13389128
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.09835572
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.05112971
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.04092298
13	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.03299789
14	P300_19829295_ChIP-Seq_ESCs_Human	2.02021575
15	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.01067959
16	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.99810267
17	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.97871706
18	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.93731987
19	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.85956490
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.81168837
21	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.79239057
22	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.75170456
23	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.73143158
24	EWS_26573619_Chip-Seq_HEK293_Human	1.72280288
25	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.69378127
26	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.68666670
27	CBP_20019798_ChIP-Seq_JUKART_Human	1.68666670
28	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.66524330
29	SMAD4_21799915_ChIP-Seq_A2780_Human	1.65318853
30	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.62944771
31	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.62189150
32	ER_23166858_ChIP-Seq_MCF-7_Human	1.58591779
33	STAT3_23295773_ChIP-Seq_U87_Human	1.57949788
34	BCAT_22108803_ChIP-Seq_LS180_Human	1.56940376
35	AR_25329375_ChIP-Seq_VCAP_Human	1.56902617
36	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.56429882
37	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.55473416
38	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.52993209
39	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.52888763
40	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.52365371
41	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.51139864
42	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.49418193
43	ELK1_19687146_ChIP-ChIP_HELA_Human	1.48236359
44	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.47958350
45	TP53_22573176_ChIP-Seq_HFKS_Human	1.42758833
46	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.42461861
47	SOX2_19829295_ChIP-Seq_ESCs_Human	1.41227613
48	NANOG_19829295_ChIP-Seq_ESCs_Human	1.41227613
49	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.40314726
50	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.39793997
51	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.38909736
52	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.38058724
53	IRF1_19129219_ChIP-ChIP_H3396_Human	1.37755823
54	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.36670538
55	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.36474176
56	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.35802702
57	TCF4_23295773_ChIP-Seq_U87_Human	1.34330209
58	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.33552359
59	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.33054453
60	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.27140453
61	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.27140453
62	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.26564206
63	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.25508279
64	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.25415455
65	P53_22387025_ChIP-Seq_ESCs_Mouse	1.24931705
66	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.24424337
67	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.22401567
68	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.21553810
69	TCF4_22108803_ChIP-Seq_LS180_Human	1.20743314
70	REST_21632747_ChIP-Seq_MESCs_Mouse	1.20109272
71	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.18187227
72	CDX2_22108803_ChIP-Seq_LS180_Human	1.18035379
73	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.17611352
74	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.17124623
75	RUNX2_22187159_ChIP-Seq_PCA_Human	1.16828880
76	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.16828862
77	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.16707791
78	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.16304510
79	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.10950787
80	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.10539338
81	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.07555375
82	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.07502415
83	P300_18555785_Chip-Seq_ESCs_Mouse	1.07229072
84	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.06426372
85	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.06064286
86	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.04177186
87	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.03638750
88	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.02792139
89	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.02625863
90	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.02330894
91	EZH2_22144423_ChIP-Seq_EOC_Human	1.02301094
92	NCOR_22424771_ChIP-Seq_293T_Human	1.00090122
93	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.00036342
94	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.98635575
95	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.96647344
96	AR_20517297_ChIP-Seq_VCAP_Human	0.96503797
97	CJUN_26792858_Chip-Seq_BT549_Human	0.96229895
98	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.95651497
99	CTCF_18555785_Chip-Seq_ESCs_Mouse	0.95461968
100	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.94897938

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.66009395
2	MP0002837_dystrophic_cardiac_calcinosis	3.64066783
3	MP0009780_abnormal_chondrocyte_physiolo	3.19854205
4	MP0001529_abnormal_vocalization	2.86286495
5	MP0005379_endocrine/exocrine_gland_phen	2.80902039
6	MP0001984_abnormal_olfaction	2.73509868
7	MP0003122_maternal_imprinting	2.65265440
8	MP0002822_catalepsy	2.52883589
9	MP0008877_abnormal_DNA_methylation	2.29003082
10	MP0003787_abnormal_imprinting	2.23582704
11	MP0005646_abnormal_pituitary_gland	2.23227975
12	MP0003950_abnormal_plasma_membrane	2.13403183
13	MP0000013_abnormal_adipose_tissue	2.13041287
14	MP0009046_muscle_twitch	2.12326324
15	MP0002102_abnormal_ear_morphology	2.10379303
16	MP0005551_abnormal_eye_electrophysiolog	2.10332252
17	MP0002163_abnormal_gland_morphology	2.09307582
18	MP0004133_heterotaxia	1.95893755
19	MP0004142_abnormal_muscle_tone	1.94280634
20	MP0002876_abnormal_thyroid_physiology	1.90866833
21	MP0008875_abnormal_xenobiotic_pharmacok	1.90227372
22	MP0006054_spinal_hemorrhage	1.86801765
23	MP0002638_abnormal_pupillary_reflex	1.85106936
24	MP0003121_genomic_imprinting	1.83859377
25	MP0005187_abnormal_penis_morphology	1.81854622
26	MP0003880_abnormal_central_pattern	1.73523032
27	MP0003011_delayed_dark_adaptation	1.66873581
28	MP0004147_increased_porphyrin_level	1.64646427
29	MP0002909_abnormal_adrenal_gland	1.63204583
30	MP0006276_abnormal_autonomic_nervous	1.61498725
31	MP0004270_analgesia	1.60299636
32	MP0009745_abnormal_behavioral_response	1.45581058
33	MP0000427_abnormal_hair_cycle	1.43718764
34	MP0002234_abnormal_pharynx_morphology	1.43643334
35	MP0000372_irregular_coat_pigmentation	1.43571105
36	MP0006072_abnormal_retinal_apoptosis	1.43229105
37	MP0002254_reproductive_system_inflammat	1.41829623
38	MP0005645_abnormal_hypothalamus_physiol	1.37576056
39	MP0005253_abnormal_eye_physiology	1.36056872
40	MP0000647_abnormal_sebaceous_gland	1.32322604
41	MP0002272_abnormal_nervous_system	1.30438778
42	MP0000516_abnormal_urinary_system	1.29484840
43	MP0005367_renal/urinary_system_phenotyp	1.29484840
44	MP0004924_abnormal_behavior	1.26659111
45	MP0005386_behavior/neurological_phenoty	1.26659111
46	MP0008789_abnormal_olfactory_epithelium	1.24048330
47	MP0000569_abnormal_digit_pigmentation	1.20441380
48	MP0010234_abnormal_vibrissa_follicle	1.17708764
49	MP0003186_abnormal_redox_activity	1.17635737
50	MP0002938_white_spotting	1.16909044
51	MP0002557_abnormal_social/conspecific_i	1.16832353
52	MP0004215_abnormal_myocardial_fiber	1.11439338
53	MP0010329_abnormal_lipoprotein_level	1.10934085
54	MP0002090_abnormal_vision	1.10681208
55	MP0001905_abnormal_dopamine_level	1.06121536
56	MP0001986_abnormal_taste_sensitivity	1.05657586
57	MP0003786_premature_aging	1.03796909
58	MP0001299_abnormal_eye_distance/	1.02468570
59	MP0001970_abnormal_pain_threshold	1.02352123
60	MP0004043_abnormal_pH_regulation	1.02269437
61	MP0002734_abnormal_mechanical_nocicepti	1.01949626
62	MP0001501_abnormal_sleep_pattern	1.01235540
63	MP0005332_abnormal_amino_acid	1.01201439
64	MP0002693_abnormal_pancreas_physiology	1.00098100
65	MP0001968_abnormal_touch/_nociception	0.99275977
66	MP0005394_taste/olfaction_phenotype	0.98608566
67	MP0005499_abnormal_olfactory_system	0.98608566
68	MP0000631_abnormal_neuroendocrine_gland	0.96694132
69	MP0010678_abnormal_skin_adnexa	0.96402707
70	MP0002572_abnormal_emotion/affect_behav	0.95720648
71	MP0001764_abnormal_homeostasis	0.94100901
72	MP0002064_seizures	0.91548177
73	MP0002160_abnormal_reproductive_system	0.90400660
74	MP0002332_abnormal_exercise_endurance	0.88713759
75	MP0003283_abnormal_digestive_organ	0.88211242
76	MP0002736_abnormal_nociception_after	0.87276188
77	MP0003136_yellow_coat_color	0.84412316
78	MP0001756_abnormal_urination	0.82065911
79	MP0005248_abnormal_Harderian_gland	0.81040913
80	MP0001944_abnormal_pancreas_morphology	0.80903734
81	MP0008872_abnormal_physiological_respon	0.80741112
82	MP0002928_abnormal_bile_duct	0.80527962
83	MP0005636_abnormal_mineral_homeostasis	0.80113129
84	MP0004085_abnormal_heartbeat	0.79683486
85	MP0004145_abnormal_muscle_electrophysio	0.78834814
86	MP0005389_reproductive_system_phenotype	0.78654070
87	MP0001486_abnormal_startle_reflex	0.77905914
88	MP0002295_abnormal_pulmonary_circulatio	0.77738803
89	MP0006036_abnormal_mitochondrial_physio	0.77583747
90	MP0008775_abnormal_heart_ventricle	0.75723767
91	MP0010386_abnormal_urinary_bladder	0.75704814
92	MP0002067_abnormal_sensory_capabilities	0.74286463
93	MP0005266_abnormal_metabolism	0.73991718
94	MP0000639_abnormal_adrenal_gland	0.69843197
95	MP0002069_abnormal_eating/drinking_beha	0.69758056
96	MP0002282_abnormal_trachea_morphology	0.69592639
97	MP0003315_abnormal_perineum_morphology	0.68765017
98	MP0005084_abnormal_gallbladder_morpholo	0.68246660
99	MP0002063_abnormal_learning/memory/cond	0.67857645
100	MP0005195_abnormal_posterior_eye	0.67738575

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Medial flaring of the eyebrow (HP:0010747)	4.19551359
2	Pancreatic fibrosis (HP:0100732)	3.93876653
3	True hermaphroditism (HP:0010459)	3.78540365
4	Gait imbalance (HP:0002141)	3.72924724
5	Congenital primary aphakia (HP:0007707)	3.63757095
6	Pancreatic cysts (HP:0001737)	3.59169276
7	Nephrogenic diabetes insipidus (HP:0009806)	3.24486276
8	Hypothermia (HP:0002045)	3.21885835
9	Nephronophthisis (HP:0000090)	3.10253067
10	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.98291705
11	Occipital encephalocele (HP:0002085)	2.92428132
12	Progressive macrocephaly (HP:0004481)	2.89752858
13	Genital tract atresia (HP:0001827)	2.86154524
14	Abnormality of midbrain morphology (HP:0002418)	2.85732066
15	Molar tooth sign on MRI (HP:0002419)	2.85732066
16	Acute necrotizing encephalopathy (HP:0006965)	2.81642274
17	Polyphagia (HP:0002591)	2.80002546
18	Short tibia (HP:0005736)	2.79234493
19	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.77446598
20	Large for gestational age (HP:0001520)	2.72368817
21	Poor suck (HP:0002033)	2.70667247
22	Vaginal atresia (HP:0000148)	2.65617334
23	Abnormality of the renal medulla (HP:0100957)	2.63275284
24	Hypoglycemic seizures (HP:0002173)	2.60322772
25	Hyperinsulinemic hypoglycemia (HP:0000825)	2.54742089
26	Hemiparesis (HP:0001269)	2.53044877
27	Hypoglycemic coma (HP:0001325)	2.52457709
28	Tongue fasciculations (HP:0001308)	2.51275341
29	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.48980531
30	Hypoplasia of the fovea (HP:0007750)	2.48980531
31	3-Methylglutaconic aciduria (HP:0003535)	2.48416428
32	Poor coordination (HP:0002370)	2.45534773
33	Acute encephalopathy (HP:0006846)	2.44535413
34	Abnormal mitochondria in muscle tissue (HP:0008316)	2.43858798
35	Upper limb muscle weakness (HP:0003484)	2.40067383
36	Increased CSF lactate (HP:0002490)	2.37957456
37	Absent speech (HP:0001344)	2.36312179
38	Decreased testicular size (HP:0008734)	2.34565946
39	Bile duct proliferation (HP:0001408)	2.30290673
40	Abnormal biliary tract physiology (HP:0012439)	2.30290673
41	Mitochondrial inheritance (HP:0001427)	2.30147461
42	Type II lissencephaly (HP:0007260)	2.28098818
43	Cystic liver disease (HP:0006706)	2.26694535
44	Hematochezia (HP:0002573)	2.24588622
45	Sclerocornea (HP:0000647)	2.23195631
46	Abnormality of the renal cortex (HP:0011035)	2.18957945
47	Severe muscular hypotonia (HP:0006829)	2.18926962
48	Specific learning disability (HP:0001328)	2.16321376
49	Methylmalonic acidemia (HP:0002912)	2.14691334
50	Abnormality of the labia minora (HP:0012880)	2.14158560
51	Type 2 muscle fiber atrophy (HP:0003554)	2.14067679
52	Adrenal hypoplasia (HP:0000835)	2.14060846
53	Furrowed tongue (HP:0000221)	2.14057186
54	Hypsarrhythmia (HP:0002521)	2.13371699
55	Chronic hepatic failure (HP:0100626)	2.10711203
56	Neonatal respiratory distress (HP:0002643)	2.10256658
57	Muscular hypotonia of the trunk (HP:0008936)	2.08857886
58	Delayed gross motor development (HP:0002194)	2.08378272
59	EEG with generalized epileptiform discharges (HP:0011198)	2.07662689
60	Exercise-induced muscle cramps (HP:0003710)	2.06371926
61	Hepatocellular necrosis (HP:0001404)	2.05735685
62	Broad foot (HP:0001769)	2.04735769
63	Methylmalonic aciduria (HP:0012120)	2.04170372
64	Hepatic necrosis (HP:0002605)	2.02146657
65	Abnormality of the fovea (HP:0000493)	2.01462352
66	Anencephaly (HP:0002323)	2.01451642
67	Metaphyseal dysplasia (HP:0100255)	2.01081232
68	Popliteal pterygium (HP:0009756)	2.00730024
69	Left ventricular hypertrophy (HP:0001712)	2.00468391
70	Renal cortical cysts (HP:0000803)	1.99805143
71	Keratoconus (HP:0000563)	1.99708178
72	Increased corneal curvature (HP:0100692)	1.99708178
73	Congenital hepatic fibrosis (HP:0002612)	1.99113388
74	Epileptiform EEG discharges (HP:0011182)	1.96234565
75	Postaxial hand polydactyly (HP:0001162)	1.96076941
76	Muscle fibrillation (HP:0010546)	1.95644411
77	Tubulointerstitial nephritis (HP:0001970)	1.95007728
78	Lissencephaly (HP:0001339)	1.93389670
79	Congenital stationary night blindness (HP:0007642)	1.93211096
80	Decreased muscle mass (HP:0003199)	1.91712862
81	Postaxial foot polydactyly (HP:0001830)	1.91513303
82	Aqueductal stenosis (HP:0002410)	1.87797295
83	Increased circulating renin level (HP:0000848)	1.87334393
84	Optic disc pallor (HP:0000543)	1.87224958
85	Congenital malformation of the right heart (HP:0011723)	1.85991772
86	Double outlet right ventricle (HP:0001719)	1.85991772
87	Male pseudohermaphroditism (HP:0000037)	1.84088278
88	Abnormality of vitamin B metabolism (HP:0004340)	1.84026988
89	Short foot (HP:0001773)	1.83222244
90	Palpebral edema (HP:0100540)	1.81613880
91	Hyperglycemia (HP:0003074)	1.80773462
92	Agitation (HP:0000713)	1.80341639
93	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	1.78561188
94	Polydipsia (HP:0001959)	1.75744771
95	Abnormal drinking behavior (HP:0030082)	1.75744771
96	Cerebral edema (HP:0002181)	1.75158852
97	Abnormality of the metopic suture (HP:0005556)	1.74653939
98	Adactyly (HP:0009776)	1.73773190
99	Ketoacidosis (HP:0001993)	1.73421069
100	Tubular atrophy (HP:0000092)	1.73222495

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.63440630
2	MAP4K2	4.94782220
3	BCR	3.02747893
4	TRIM28	2.83856965
5	MST4	2.31836129
6	WNK3	2.26461312
7	PAK3	2.23656934
8	PINK1	2.18209597
9	BMPR1B	1.90304497
10	PLK2	1.84618391
11	CASK	1.84151173
12	ERBB3	1.82020656
13	MAP3K12	1.80962203
14	STK24	1.80848103
15	LIMK1	1.80597529
16	FGFR2	1.77657173
17	TNIK	1.75049765
18	MAPK13	1.74825458
19	NUAK1	1.73953597
20	GRK1	1.72934267
21	STK3	1.66861992
22	MAP3K4	1.65770525
23	FER	1.59889035
24	PHKG1	1.54995510
25	PHKG2	1.54995510
26	CSNK1G2	1.54140341
27	ADRBK2	1.50272513
28	CSNK1G3	1.43839916
29	CSNK1G1	1.41521171
30	MUSK	1.40674563
31	CSNK1A1L	1.38114118
32	MARK1	1.36647453
33	STK39	1.32829750
34	PRKCE	1.26425395
35	MKNK2	1.25953146
36	STK38L	1.25006282
37	WNK4	1.23149642
38	DAPK2	1.07713487
39	SIK3	1.07210589
40	EPHA3	1.04555207
41	MAP2K7	1.03794603
42	PRKCG	0.98945628
43	PLK3	0.96280607
44	TIE1	0.95671923
45	DYRK3	0.95598583
46	BCKDK	0.94766725
47	OXSR1	0.90312656
48	NTRK3	0.89730985
49	DYRK2	0.89060636
50	EIF2AK1	0.87520500
51	INSRR	0.79826223
52	ZAK	0.77659297
53	MINK1	0.74799227
54	LATS1	0.73489800
55	NTRK2	0.71994108
56	PTK2B	0.69009861
57	PRKCI	0.68824266
58	CAMK2D	0.68488166
59	TESK1	0.68200417
60	MAP3K9	0.61053566
61	EPHA4	0.61046170
62	PDK2	0.60919619
63	EIF2AK3	0.58660821
64	CSNK1A1	0.53855150
65	PIK3CA	0.52430130
66	MKNK1	0.51285957
67	DYRK1A	0.50536446
68	PRKAA1	0.50152487
69	CAMK2A	0.49296365
70	STK16	0.48456452
71	MET	0.48220275
72	MAP2K6	0.47881880
73	NEK1	0.47490407
74	MYLK	0.45508009
75	PRKAA2	0.44928429
76	CDK3	0.42209932
77	PRKACA	0.40132729
78	PRKCZ	0.40022129
79	CSNK1D	0.39238597
80	ACVR1B	0.37211302
81	ROCK1	0.37188392
82	ADRBK1	0.36727852
83	VRK1	0.36501118
84	TXK	0.35569485
85	FGFR1	0.35109921
86	FGFR3	0.34476590
87	PRKCQ	0.34174362
88	PRKD3	0.33186980
89	CDK5	0.30471126
90	ABL1	0.30223531
91	LMTK2	0.30207098
92	PRKACB	0.29924364
93	PRKCA	0.29723959
94	PRKG1	0.29158577
95	MAP2K4	0.28777843
96	PLK1	0.28309447
97	ILK	0.27003240
98	EGFR	0.26882874
99	NME1	0.25904475
100	FLT3	0.25757274

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.49214538
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.74843960
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.70134212
4	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.58878837
5	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.30519355
6	Butanoate metabolism_Homo sapiens_hsa00650	2.29607056
7	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.25184269
8	Phototransduction_Homo sapiens_hsa04744	2.23870899
9	Oxidative phosphorylation_Homo sapiens_hsa00190	2.11546983
10	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.11371037
11	Propanoate metabolism_Homo sapiens_hsa00640	1.98409631
12	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.88932460
13	Circadian rhythm_Homo sapiens_hsa04710	1.86594495
14	Selenocompound metabolism_Homo sapiens_hsa00450	1.82387135
15	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.78474683
16	Steroid biosynthesis_Homo sapiens_hsa00100	1.69777444
17	Sulfur metabolism_Homo sapiens_hsa00920	1.55591631
18	Peroxisome_Homo sapiens_hsa04146	1.45662837
19	Collecting duct acid secretion_Homo sapiens_hsa04966	1.44789491
20	Parkinsons disease_Homo sapiens_hsa05012	1.31370330
21	GABAergic synapse_Homo sapiens_hsa04727	1.30643804
22	Fatty acid elongation_Homo sapiens_hsa00062	1.29463728
23	Nicotine addiction_Homo sapiens_hsa05033	1.27631008
24	Insulin secretion_Homo sapiens_hsa04911	1.27625036
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.27266933
26	Ether lipid metabolism_Homo sapiens_hsa00565	1.26389948
27	Proteasome_Homo sapiens_hsa03050	1.25842015
28	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.23629521
29	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.17754761
30	Nitrogen metabolism_Homo sapiens_hsa00910	1.14825719
31	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.14085025
32	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.13216869
33	Linoleic acid metabolism_Homo sapiens_hsa00591	1.12788865
34	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.12758262
35	Regulation of autophagy_Homo sapiens_hsa04140	1.11294956
36	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.11255239
37	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.09924941
38	Mineral absorption_Homo sapiens_hsa04978	1.07603051
39	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.07411821
40	Vibrio cholerae infection_Homo sapiens_hsa05110	1.07118325
41	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.06711353
42	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.06150783
43	beta-Alanine metabolism_Homo sapiens_hsa00410	1.05598310
44	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.04502428
45	RNA polymerase_Homo sapiens_hsa03020	1.02130433
46	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.00603446
47	Morphine addiction_Homo sapiens_hsa05032	0.98904238
48	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.98419169
49	ABC transporters_Homo sapiens_hsa02010	0.97769467
50	Basal transcription factors_Homo sapiens_hsa03022	0.96341461
51	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.96046559
52	Dopaminergic synapse_Homo sapiens_hsa04728	0.95899807
53	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.95861265
54	Alzheimers disease_Homo sapiens_hsa05010	0.95042590
55	Folate biosynthesis_Homo sapiens_hsa00790	0.94915368
56	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.92836423
57	Fanconi anemia pathway_Homo sapiens_hsa03460	0.92409220
58	Huntingtons disease_Homo sapiens_hsa05016	0.91371255
59	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.90503363
60	Caffeine metabolism_Homo sapiens_hsa00232	0.89658236
61	Glutathione metabolism_Homo sapiens_hsa00480	0.85913317
62	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.85293396
63	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.84949568
64	Chemical carcinogenesis_Homo sapiens_hsa05204	0.84027992
65	Taste transduction_Homo sapiens_hsa04742	0.83386012
66	Metabolic pathways_Homo sapiens_hsa01100	0.81149212
67	Olfactory transduction_Homo sapiens_hsa04740	0.79929317
68	Retinol metabolism_Homo sapiens_hsa00830	0.79772066
69	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.79051660
70	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.75781363
71	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.71445113
72	Arginine and proline metabolism_Homo sapiens_hsa00330	0.70165805
73	Glutamatergic synapse_Homo sapiens_hsa04724	0.69902894
74	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.67824734
75	Serotonergic synapse_Homo sapiens_hsa04726	0.66289414
76	RNA degradation_Homo sapiens_hsa03018	0.64829286
77	Cardiac muscle contraction_Homo sapiens_hsa04260	0.64633074
78	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.64200734
79	Circadian entrainment_Homo sapiens_hsa04713	0.64137807
80	Fatty acid metabolism_Homo sapiens_hsa01212	0.62932941
81	Amphetamine addiction_Homo sapiens_hsa05031	0.62592346
82	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.61622850
83	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.61444242
84	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.58426429
85	Salivary secretion_Homo sapiens_hsa04970	0.57377704
86	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.56731116
87	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.53887630
88	Sphingolipid metabolism_Homo sapiens_hsa00600	0.53602947
89	Glucagon signaling pathway_Homo sapiens_hsa04922	0.52754258
90	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.48377332
91	Arginine biosynthesis_Homo sapiens_hsa00220	0.47984418
92	Fat digestion and absorption_Homo sapiens_hsa04975	0.47009050
93	Purine metabolism_Homo sapiens_hsa00230	0.46858537
94	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.44107559
95	Pyruvate metabolism_Homo sapiens_hsa00620	0.42997621
96	Glycerolipid metabolism_Homo sapiens_hsa00561	0.42191773
97	Oocyte meiosis_Homo sapiens_hsa04114	0.41979421
98	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.39920190
99	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.39467620
100	Tyrosine metabolism_Homo sapiens_hsa00350	0.38071834

BMS1P11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »