ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein polyglutamylation (GO:0018095)	4.55202556
2	water-soluble vitamin biosynthetic process (GO:0042364)	4.47930999
3	nonmotile primary cilium assembly (GO:0035058)	4.41332593
4	regulation of cilium movement (GO:0003352)	4.35439938
5	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	4.00229177
6	DNA deamination (GO:0045006)	3.84073134
7	peptidyl-histidine modification (GO:0018202)	3.53581862
8	regulation of glucokinase activity (GO:0033131)	3.49275311
9	regulation of hexokinase activity (GO:1903299)	3.49275311
10	amino acid salvage (GO:0043102)	3.49231631
11	L-methionine salvage (GO:0071267)	3.49231631
12	L-methionine biosynthetic process (GO:0071265)	3.49231631
13	preassembly of GPI anchor in ER membrane (GO:0016254)	3.44611001
14	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.43573485
15	regulation of mitochondrial translation (GO:0070129)	3.41935935
16	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.39804647
17	epithelial cilium movement (GO:0003351)	3.37701469
18	protein complex biogenesis (GO:0070271)	3.35555154
19	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.33728022
20	mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)	3.33640046
21	respiratory chain complex IV assembly (GO:0008535)	3.32476250
22	intraciliary transport (GO:0042073)	3.28427523
23	kidney morphogenesis (GO:0060993)	3.27811922
24	proteasome assembly (GO:0043248)	3.25069889
25	axoneme assembly (GO:0035082)	3.21429475
26	fucose catabolic process (GO:0019317)	3.18967374
27	L-fucose metabolic process (GO:0042354)	3.18967374
28	L-fucose catabolic process (GO:0042355)	3.18967374
29	ATP synthesis coupled proton transport (GO:0015986)	3.11585197
30	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.11585197
31	regulation of microtubule-based movement (GO:0060632)	3.10939960
32	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.10765525
33	rRNA catabolic process (GO:0016075)	3.10177441
34	cytochrome complex assembly (GO:0017004)	3.06722760
35	cellular ketone body metabolic process (GO:0046950)	3.02453102
36	proline transport (GO:0015824)	3.00817915
37	organelle disassembly (GO:1903008)	3.00553551
38	cilium morphogenesis (GO:0060271)	3.00436767
39	pyrimidine nucleobase catabolic process (GO:0006208)	3.00211734
40	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.98814775
41	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.98814775
42	NADH dehydrogenase complex assembly (GO:0010257)	2.98814775
43	mitochondrial respiratory chain complex assembly (GO:0033108)	2.98777921
44	ubiquinone biosynthetic process (GO:0006744)	2.98694680
45	DNA double-strand break processing (GO:0000729)	2.93155586
46	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.87251616
47	cilium organization (GO:0044782)	2.85514559
48	cilium assembly (GO:0042384)	2.83046991
49	negative regulation of telomere maintenance (GO:0032205)	2.82479775
50	ubiquinone metabolic process (GO:0006743)	2.82357424
51	negative regulation of macrophage differentiation (GO:0045650)	2.81273164
52	mesenchymal cell differentiation involved in kidney development (GO:0072161)	2.80496926
53	mesenchymal cell differentiation involved in renal system development (GO:2001012)	2.80496926
54	negative regulation of appetite (GO:0032099)	2.77709596
55	negative regulation of response to food (GO:0032096)	2.77709596
56	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.77686829
57	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.77686829
58	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.77327671
59	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.73256091
60	synaptic transmission, glutamatergic (GO:0035249)	2.71845229
61	response to pheromone (GO:0019236)	2.71716573
62	signal peptide processing (GO:0006465)	2.70578272
63	photoreceptor cell development (GO:0042461)	2.69353252
64	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.69221560
65	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.66791879
66	GPI anchor metabolic process (GO:0006505)	2.66195831
67	nucleobase catabolic process (GO:0046113)	2.65724762
68	C4-dicarboxylate transport (GO:0015740)	2.64867674
69	ketone body metabolic process (GO:1902224)	2.64650109
70	parturition (GO:0007567)	2.63832930
71	photoreceptor cell maintenance (GO:0045494)	2.63706221
72	protein prenylation (GO:0018342)	2.59968935
73	prenylation (GO:0097354)	2.59968935
74	cullin deneddylation (GO:0010388)	2.57309925
75	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.57279332
76	peptidyl-cysteine modification (GO:0018198)	2.56324420
77	gamma-aminobutyric acid transport (GO:0015812)	2.52834367
78	eye photoreceptor cell development (GO:0042462)	2.51319291
79	retinal cone cell development (GO:0046549)	2.50381178
80	axonal fasciculation (GO:0007413)	2.48990408
81	viral mRNA export from host cell nucleus (GO:0046784)	2.48118377
82	pyrimidine dimer repair (GO:0006290)	2.43907540
83	inositol phosphate catabolic process (GO:0071545)	2.43169641
84	regulation of mesoderm development (GO:2000380)	2.42022894
85	quinone biosynthetic process (GO:1901663)	2.41619440
86	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.40284729
87	maturation of 5.8S rRNA (GO:0000460)	2.40227779
88	melanosome transport (GO:0032402)	2.40181159
89	protein localization to cilium (GO:0061512)	2.40063454
90	regulation of cofactor metabolic process (GO:0051193)	2.39132200
91	regulation of coenzyme metabolic process (GO:0051196)	2.39132200
92	isotype switching (GO:0045190)	2.39093697
93	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.39093697
94	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.39093697
95	cilium movement (GO:0003341)	2.39074635
96	vitamin biosynthetic process (GO:0009110)	2.38601039
97	cellular response to leptin stimulus (GO:0044320)	2.37749667
98	substrate-independent telencephalic tangential migration (GO:0021826)	2.37352630
99	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.37352630
100	establishment of melanosome localization (GO:0032401)	2.36248874

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.58648030
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.35796517
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.17802849
4	VDR_22108803_ChIP-Seq_LS180_Human	3.16234505
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.83497901
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.62140515
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.62138981
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.60561756
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.60121651
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.57378721
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.53592487
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.44222855
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.32599400
14	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.22309876
15	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.08801759
16	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.07584578
17	TAF15_26573619_Chip-Seq_HEK293_Human	2.05587374
18	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.02366412
19	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.91867436
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.91356611
21	FUS_26573619_Chip-Seq_HEK293_Human	1.86842841
22	P300_19829295_ChIP-Seq_ESCs_Human	1.85598482
23	EWS_26573619_Chip-Seq_HEK293_Human	1.84010574
24	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.81593816
25	CBP_20019798_ChIP-Seq_JUKART_Human	1.78722010
26	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.78722010
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.77172791
28	IRF1_19129219_ChIP-ChIP_H3396_Human	1.76873445
29	ELK1_19687146_ChIP-ChIP_HELA_Human	1.74474454
30	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.74075343
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.73781601
32	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.69176548
33	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.64829764
34	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.63472503
35	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.54726945
36	ER_23166858_ChIP-Seq_MCF-7_Human	1.48113605
37	VDR_23849224_ChIP-Seq_CD4+_Human	1.48012004
38	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.47634740
39	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.46579534
40	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.45811833
41	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.44932705
42	RNF2_27304074_Chip-Seq_NSC_Mouse	1.44719627
43	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.43024038
44	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.41966678
45	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.40541134
46	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.37934151
47	MYC_18940864_ChIP-ChIP_HL60_Human	1.36162667
48	SMAD4_21799915_ChIP-Seq_A2780_Human	1.34443610
49	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.33521170
50	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.32877180
51	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.31837335
52	BCAT_22108803_ChIP-Seq_LS180_Human	1.30109122
53	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.29710267
54	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.29569497
55	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.29439575
56	REST_21632747_ChIP-Seq_MESCs_Mouse	1.27998615
57	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.26498343
58	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.24450433
59	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.23745423
60	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.23657544
61	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.23462112
62	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.23170171
63	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.20314093
64	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.20016852
65	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.18967171
66	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.18937389
67	TCF4_22108803_ChIP-Seq_LS180_Human	1.18043696
68	STAT3_23295773_ChIP-Seq_U87_Human	1.18001861
69	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.16689003
70	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.16439364
71	TCF4_23295773_ChIP-Seq_U87_Human	1.15845830
72	NANOG_19829295_ChIP-Seq_ESCs_Human	1.14802653
73	SOX2_19829295_ChIP-Seq_ESCs_Human	1.14802653
74	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.13789679
75	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.12963294
76	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.10946532
77	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.10762042
78	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.10138357
79	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.09236613
80	NCOR_22424771_ChIP-Seq_293T_Human	1.09071457
81	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.08161411
82	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.07345462
83	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.05825835
84	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.05825835
85	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.05736368
86	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.05366397
87	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.04565337
88	RUNX2_22187159_ChIP-Seq_PCA_Human	1.02399949
89	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.02310249
90	AR_25329375_ChIP-Seq_VCAP_Human	1.01956378
91	JUN_21703547_ChIP-Seq_K562_Human	1.01861175
92	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.01796936
93	FOXP3_21729870_ChIP-Seq_TREG_Human	1.00588891
94	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.99959336
95	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.97500705
96	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.97181655
97	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.97126148
98	AR_20517297_ChIP-Seq_VCAP_Human	0.96747805
99	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.96252176
100	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.95657909

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003122_maternal_imprinting	3.13138124
2	MP0008789_abnormal_olfactory_epithelium	3.12566506
3	MP0001529_abnormal_vocalization	3.11230734
4	MP0003787_abnormal_imprinting	3.04173520
5	MP0003195_calcinosis	2.86268696
6	MP0005394_taste/olfaction_phenotype	2.76482562
7	MP0005499_abnormal_olfactory_system	2.76482562
8	MP0001984_abnormal_olfaction	2.59599341
9	MP0002102_abnormal_ear_morphology	2.56988355
10	MP0005360_urolithiasis	2.48759948
11	MP0008877_abnormal_DNA_methylation	2.42535338
12	MP0006072_abnormal_retinal_apoptosis	2.40744047
13	MP0003121_genomic_imprinting	2.27577530
14	MP0002822_catalepsy	2.24893738
15	MP0002837_dystrophic_cardiac_calcinosis	2.09978639
16	MP0002163_abnormal_gland_morphology	2.03756037
17	MP0006292_abnormal_olfactory_placode	2.03019452
18	MP0005379_endocrine/exocrine_gland_phen	1.94537328
19	MP0006276_abnormal_autonomic_nervous	1.89634696
20	MP0004133_heterotaxia	1.88081353
21	MP0005253_abnormal_eye_physiology	1.80500628
22	MP0005551_abnormal_eye_electrophysiolog	1.75116153
23	MP0004142_abnormal_muscle_tone	1.74813389
24	MP0009046_muscle_twitch	1.58005576
25	MP0001293_anophthalmia	1.54368188
26	MP0002928_abnormal_bile_duct	1.54173403
27	MP0002938_white_spotting	1.52732668
28	MP0003880_abnormal_central_pattern	1.49011318
29	MP0002638_abnormal_pupillary_reflex	1.48427657
30	MP0009745_abnormal_behavioral_response	1.43583899
31	MP0002272_abnormal_nervous_system	1.42367623
32	MP0006054_spinal_hemorrhage	1.40485514
33	MP0002160_abnormal_reproductive_system	1.38829910
34	MP0008058_abnormal_DNA_repair	1.38025386
35	MP0001486_abnormal_startle_reflex	1.37424758
36	MP0002653_abnormal_ependyma_morphology	1.32779410
37	MP0002909_abnormal_adrenal_gland	1.31716073
38	MP0004043_abnormal_pH_regulation	1.31221059
39	MP0002733_abnormal_thermal_nociception	1.30446975
40	MP0008995_early_reproductive_senescence	1.29333772
41	MP0000778_abnormal_nervous_system	1.29083705
42	MP0002557_abnormal_social/conspecific_i	1.27508195
43	MP0004885_abnormal_endolymph	1.26250380
44	MP0002064_seizures	1.24763720
45	MP0003011_delayed_dark_adaptation	1.23719992
46	MP0001970_abnormal_pain_threshold	1.23275387
47	MP0004270_analgesia	1.21287603
48	MP0000631_abnormal_neuroendocrine_gland	1.19979412
49	MP0000569_abnormal_digit_pigmentation	1.19490723
50	MP0005646_abnormal_pituitary_gland	1.19211664
51	MP0002876_abnormal_thyroid_physiology	1.16414039
52	MP0001968_abnormal_touch/_nociception	1.16402304
53	MP0003890_abnormal_embryonic-extraembry	1.14715647
54	MP0005389_reproductive_system_phenotype	1.14484606
55	MP0002572_abnormal_emotion/affect_behav	1.12818373
56	MP0002736_abnormal_nociception_after	1.10106710
57	MP0003635_abnormal_synaptic_transmissio	1.08387812
58	MP0000427_abnormal_hair_cycle	1.08155750
59	MP0000013_abnormal_adipose_tissue	1.06489264
60	MP0002090_abnormal_vision	1.02925982
61	MP0001440_abnormal_grooming_behavior	1.01159993
62	MP0002233_abnormal_nose_morphology	1.01131692
63	MP0004215_abnormal_myocardial_fiber	1.00558747
64	MP0003119_abnormal_digestive_system	1.00434626
65	MP0002734_abnormal_mechanical_nocicepti	0.99637787
66	MP0002735_abnormal_chemical_nociception	0.98254107
67	MP0003937_abnormal_limbs/digits/tail_de	0.94179198
68	MP0008875_abnormal_xenobiotic_pharmacok	0.93645578
69	MP0001485_abnormal_pinna_reflex	0.93191157
70	MP0005195_abnormal_posterior_eye	0.92969111
71	MP0003283_abnormal_digestive_organ	0.91556919
72	MP0010329_abnormal_lipoprotein_level	0.91310902
73	MP0000372_irregular_coat_pigmentation	0.90430501
74	MP0002184_abnormal_innervation	0.90101967
75	MP0003786_premature_aging	0.88406899
76	MP0002752_abnormal_somatic_nervous	0.88226480
77	MP0005391_vision/eye_phenotype	0.87945533
78	MP0002063_abnormal_learning/memory/cond	0.86882359
79	MP0001905_abnormal_dopamine_level	0.84754369
80	MP0005645_abnormal_hypothalamus_physiol	0.83679299
81	MP0002234_abnormal_pharynx_morphology	0.83673636
82	MP0004085_abnormal_heartbeat	0.83394787
83	MP0001764_abnormal_homeostasis	0.83079661
84	MP0002751_abnormal_autonomic_nervous	0.82258920
85	MP0004924_abnormal_behavior	0.82244820
86	MP0005386_behavior/neurological_phenoty	0.82244820
87	MP0008872_abnormal_physiological_respon	0.80603311
88	MP0001501_abnormal_sleep_pattern	0.79744127
89	MP0002210_abnormal_sex_determination	0.79727908
90	MP0000653_abnormal_sex_gland	0.79214583
91	MP0001944_abnormal_pancreas_morphology	0.78724543
92	MP0001929_abnormal_gametogenesis	0.78719285
93	MP0002067_abnormal_sensory_capabilities	0.77045087
94	MP0004145_abnormal_muscle_electrophysio	0.76603301
95	MP0009780_abnormal_chondrocyte_physiolo	0.76443120
96	MP0000955_abnormal_spinal_cord	0.75759749
97	MP0001188_hyperpigmentation	0.74927659
98	MP0009697_abnormal_copulation	0.74851988
99	MP0000049_abnormal_middle_ear	0.73858901
100	MP0002127_abnormal_cardiovascular_syste	0.73605003

Predicted human phenotypes

Rank	Gene Set	Z-score
1	True hermaphroditism (HP:0010459)	4.20650693
2	Medial flaring of the eyebrow (HP:0010747)	3.88743840
3	Pancreatic fibrosis (HP:0100732)	3.72918461
4	Abnormality of the labia minora (HP:0012880)	3.70862346
5	Molar tooth sign on MRI (HP:0002419)	3.30409580
6	Abnormality of midbrain morphology (HP:0002418)	3.30409580
7	Gait imbalance (HP:0002141)	3.22976705
8	Congenital primary aphakia (HP:0007707)	3.15846789
9	Methylmalonic acidemia (HP:0002912)	3.14169755
10	Pancreatic cysts (HP:0001737)	3.07319511
11	3-Methylglutaconic aciduria (HP:0003535)	3.01773426
12	Nephronophthisis (HP:0000090)	2.98612527
13	Nephrogenic diabetes insipidus (HP:0009806)	2.90943091
14	Acute necrotizing encephalopathy (HP:0006965)	2.83066267
15	Supernumerary spleens (HP:0009799)	2.78646997
16	Polyphagia (HP:0002591)	2.77456281
17	Methylmalonic aciduria (HP:0012120)	2.61109968
18	Progressive macrocephaly (HP:0004481)	2.55563496
19	Chronic hepatic failure (HP:0100626)	2.54820520
20	Acute encephalopathy (HP:0006846)	2.53947803
21	Hyperglycinemia (HP:0002154)	2.53343183
22	Hyperglycinuria (HP:0003108)	2.52169848
23	Genital tract atresia (HP:0001827)	2.51469542
24	Poor suck (HP:0002033)	2.51284645
25	Abnormality of the renal medulla (HP:0100957)	2.46950087
26	Male pseudohermaphroditism (HP:0000037)	2.44720634
27	Vaginal atresia (HP:0000148)	2.40419201
28	Hepatic necrosis (HP:0002605)	2.36466531
29	Anomalous pulmonary venous return (HP:0010772)	2.34223149
30	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.32322932
31	Abnormality of alanine metabolism (HP:0010916)	2.32322932
32	Hyperalaninemia (HP:0003348)	2.32322932
33	Renal cortical cysts (HP:0000803)	2.32143656
34	Abnormal mitochondria in muscle tissue (HP:0008316)	2.32038553
35	Intestinal atresia (HP:0011100)	2.30117129
36	Increased CSF lactate (HP:0002490)	2.29616263
37	Specific learning disability (HP:0001328)	2.27309327
38	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.26853530
39	Sclerocornea (HP:0000647)	2.25533026
40	Hypomagnesemia (HP:0002917)	2.25181556
41	Postaxial hand polydactyly (HP:0001162)	2.22251367
42	Abolished electroretinogram (ERG) (HP:0000550)	2.22236170
43	Hypoglycemic coma (HP:0001325)	2.21039434
44	Congenital hepatic fibrosis (HP:0002612)	2.19666218
45	Mitochondrial inheritance (HP:0001427)	2.19570527
46	Cystic liver disease (HP:0006706)	2.18674290
47	Hypothermia (HP:0002045)	2.17147815
48	Failure to thrive in infancy (HP:0001531)	2.16302135
49	Atonic seizures (HP:0010819)	2.15519473
50	Abnormality of glycine metabolism (HP:0010895)	2.15279747
51	Abnormality of serine family amino acid metabolism (HP:0010894)	2.15279747
52	Narrow forehead (HP:0000341)	2.13622006
53	Postaxial foot polydactyly (HP:0001830)	2.12572920
54	Abnormal rod and cone electroretinograms (HP:0008323)	2.12571162
55	Abnormal biliary tract physiology (HP:0012439)	2.12543608
56	Bile duct proliferation (HP:0001408)	2.12543608
57	Colon cancer (HP:0003003)	2.12047931
58	Hepatocellular necrosis (HP:0001404)	2.11818000
59	Hemiparesis (HP:0001269)	2.11566107
60	Hip dysplasia (HP:0001385)	2.11064944
61	Abnormal respiratory epithelium morphology (HP:0012253)	2.10673390
62	Abnormal respiratory motile cilium morphology (HP:0005938)	2.10673390
63	Asplenia (HP:0001746)	2.09492323
64	Severe muscular hypotonia (HP:0006829)	2.07444413
65	Abnormality of vitamin B metabolism (HP:0004340)	2.06029830
66	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.05629872
67	Pachygyria (HP:0001302)	2.03505505
68	Abnormality of the pulmonary veins (HP:0011718)	1.99349227
69	Tongue fasciculations (HP:0001308)	1.97529933
70	Progressive cerebellar ataxia (HP:0002073)	1.97411728
71	Type II lissencephaly (HP:0007260)	1.95271618
72	Occipital encephalocele (HP:0002085)	1.92875559
73	Poor coordination (HP:0002370)	1.92427675
74	Hyperinsulinemic hypoglycemia (HP:0000825)	1.91124076
75	Abnormality of the renal cortex (HP:0011035)	1.90738304
76	Cerebellar dysplasia (HP:0007033)	1.90649224
77	Myokymia (HP:0002411)	1.89490894
78	Abnormality of the anterior horn cell (HP:0006802)	1.88683926
79	Degeneration of anterior horn cells (HP:0002398)	1.88683926
80	Pendular nystagmus (HP:0012043)	1.87920755
81	Adactyly (HP:0009776)	1.87189873
82	Febrile seizures (HP:0002373)	1.86422337
83	Abnormality of the metopic suture (HP:0005556)	1.85695072
84	Short tibia (HP:0005736)	1.84531236
85	Lissencephaly (HP:0001339)	1.81785719
86	Anencephaly (HP:0002323)	1.81077122
87	Aplasia/hypoplasia of the uterus (HP:0008684)	1.81054620
88	Oligodactyly (hands) (HP:0001180)	1.79298817
89	Decreased testicular size (HP:0008734)	1.77500730
90	Agitation (HP:0000713)	1.77098559
91	Ketoacidosis (HP:0001993)	1.76042303
92	Broad foot (HP:0001769)	1.75789851
93	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.75707289
94	Adrenal hypoplasia (HP:0000835)	1.75357162
95	Abnormal eating behavior (HP:0100738)	1.74941328
96	Broad-based gait (HP:0002136)	1.73350457
97	Increased serum lactate (HP:0002151)	1.73338690
98	Abnormality of magnesium homeostasis (HP:0004921)	1.72438848
99	EEG with generalized epileptiform discharges (HP:0011198)	1.71723846
100	Growth hormone deficiency (HP:0000824)	1.71596316

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.01357638
2	FRK	3.69673830
3	WNK3	3.55425450
4	BMPR1B	2.92702794
5	PINK1	2.76635860
6	STK16	2.33932639
7	MAP3K4	2.25729011
8	CAMKK2	2.11404149
9	GRK1	2.06064128
10	BRSK2	1.90960938
11	PLK2	1.89144178
12	MAP2K7	1.85706317
13	ADRBK2	1.82924312
14	ACVR1B	1.75548840
15	MST4	1.70632909
16	EIF2AK3	1.60597700
17	BCR	1.58495730
18	ZAK	1.54471887
19	PHKG1	1.52631256
20	PHKG2	1.52631256
21	BCKDK	1.52119455
22	PAK3	1.49281442
23	NUAK1	1.48973903
24	PDK2	1.43350910
25	MAPK13	1.32195172
26	MARK1	1.30218600
27	MAP3K12	1.29678995
28	PKN2	1.27214241
29	DYRK2	1.26727574
30	CSNK1G3	1.26560642
31	CSNK1G2	1.24392048
32	FLT3	1.24040174
33	CSNK1G1	1.22194794
34	MKNK2	1.21051347
35	CDK8	1.20101899
36	WNK4	1.19698944
37	FGFR2	1.18743056
38	EIF2AK1	1.15624157
39	INSRR	1.11890977
40	TRIM28	1.10666982
41	PRKCG	1.10587980
42	TNIK	1.09254206
43	STK38L	1.08717778
44	PLK3	1.08243478
45	TIE1	1.06124021
46	TAOK3	1.05165286
47	CSNK1A1L	1.05083062
48	ERBB3	1.04843726
49	SRPK1	0.99913097
50	EPHA4	0.99675820
51	TGFBR1	0.98213050
52	PLK4	0.97213408
53	DAPK2	0.94988652
54	VRK1	0.94938182
55	BRSK1	0.94790446
56	PRKCE	0.90707346
57	DYRK3	0.82436536
58	MKNK1	0.80573838
59	NEK1	0.80328206
60	DYRK1A	0.79203516
61	TAF1	0.72977955
62	PAK6	0.72972304
63	MAP2K4	0.71050461
64	OBSCN	0.66250031
65	LIMK1	0.66035120
66	IRAK1	0.64297450
67	VRK2	0.63902005
68	CASK	0.61240717
69	IRAK2	0.59659907
70	BRD4	0.58471837
71	ADRBK1	0.57011680
72	PLK1	0.53190931
73	PTK2B	0.53161119
74	PRKCI	0.52998286
75	PRKACA	0.52094592
76	BUB1	0.49331353
77	PASK	0.48853321
78	CCNB1	0.47685759
79	FER	0.46199593
80	PBK	0.46109082
81	PRKAA1	0.43702303
82	CAMK2A	0.43509936
83	NTRK2	0.39664509
84	CAMK2D	0.39253380
85	TLK1	0.38957910
86	FGFR1	0.37960084
87	SGK494	0.37891158
88	SGK223	0.37891158
89	PRKACB	0.37841711
90	MUSK	0.33328404
91	CAMK2B	0.33317674
92	RPS6KA5	0.31178267
93	CSNK2A1	0.30871314
94	SIK2	0.30596400
95	CSNK1E	0.29969342
96	PRKCZ	0.29840382
97	OXSR1	0.29464578
98	PRKCA	0.29320211
99	RPS6KA4	0.28761395
100	GRK7	0.28701389

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.79987921
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.06834470
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.80021939
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.70020187
5	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.44617980
6	Parkinsons disease_Homo sapiens_hsa05012	2.34588030
7	Butanoate metabolism_Homo sapiens_hsa00650	2.24486900
8	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.15977431
9	Nicotine addiction_Homo sapiens_hsa05033	2.12259006
10	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.95015933
11	Basal transcription factors_Homo sapiens_hsa03022	1.86514124
12	Propanoate metabolism_Homo sapiens_hsa00640	1.85398658
13	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.75639209
14	Steroid biosynthesis_Homo sapiens_hsa00100	1.75629493
15	RNA degradation_Homo sapiens_hsa03018	1.71204530
16	RNA polymerase_Homo sapiens_hsa03020	1.70149406
17	Regulation of autophagy_Homo sapiens_hsa04140	1.70055114
18	Phototransduction_Homo sapiens_hsa04744	1.64478660
19	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.58263374
20	Alzheimers disease_Homo sapiens_hsa05010	1.55921405
21	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.55792386
22	Proteasome_Homo sapiens_hsa03050	1.54452623
23	Huntingtons disease_Homo sapiens_hsa05016	1.51016359
24	GABAergic synapse_Homo sapiens_hsa04727	1.40868081
25	Collecting duct acid secretion_Homo sapiens_hsa04966	1.39389485
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.37504607
27	Peroxisome_Homo sapiens_hsa04146	1.37397618
28	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.26683593
29	Cardiac muscle contraction_Homo sapiens_hsa04260	1.24123047
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.20582495
31	Fanconi anemia pathway_Homo sapiens_hsa03460	1.18060120
32	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.17527050
33	Taste transduction_Homo sapiens_hsa04742	1.16747320
34	Insulin secretion_Homo sapiens_hsa04911	1.15989180
35	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.15031892
36	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.12849437
37	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.12630443
38	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.09293810
39	Fatty acid elongation_Homo sapiens_hsa00062	1.06343503
40	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.05580303
41	Tryptophan metabolism_Homo sapiens_hsa00380	1.01745917
42	Circadian rhythm_Homo sapiens_hsa04710	1.01336917
43	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.00186402
44	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.99005308
45	Nitrogen metabolism_Homo sapiens_hsa00910	0.97933955
46	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.97322871
47	Nucleotide excision repair_Homo sapiens_hsa03420	0.96194166
48	Caffeine metabolism_Homo sapiens_hsa00232	0.94016771
49	Mismatch repair_Homo sapiens_hsa03430	0.92954440
50	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.92796077
51	Ether lipid metabolism_Homo sapiens_hsa00565	0.92453110
52	Olfactory transduction_Homo sapiens_hsa04740	0.91758878
53	Glutamatergic synapse_Homo sapiens_hsa04724	0.90834733
54	Pyruvate metabolism_Homo sapiens_hsa00620	0.90648933
55	Morphine addiction_Homo sapiens_hsa05032	0.90388581
56	Cocaine addiction_Homo sapiens_hsa05030	0.89353831
57	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.88950506
58	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.85755211
59	Non-homologous end-joining_Homo sapiens_hsa03450	0.85294980
60	Selenocompound metabolism_Homo sapiens_hsa00450	0.84641651
61	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.84509754
62	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.83307499
63	Circadian entrainment_Homo sapiens_hsa04713	0.81757013
64	Metabolic pathways_Homo sapiens_hsa01100	0.81029805
65	Chemical carcinogenesis_Homo sapiens_hsa05204	0.79608589
66	Glutathione metabolism_Homo sapiens_hsa00480	0.76394919
67	Serotonergic synapse_Homo sapiens_hsa04726	0.76105291
68	Retinol metabolism_Homo sapiens_hsa00830	0.75628362
69	Amphetamine addiction_Homo sapiens_hsa05031	0.73904497
70	beta-Alanine metabolism_Homo sapiens_hsa00410	0.72615582
71	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.71856370
72	Dopaminergic synapse_Homo sapiens_hsa04728	0.71459963
73	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.70211351
74	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.69870188
75	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.68680213
76	Purine metabolism_Homo sapiens_hsa00230	0.66742784
77	Homologous recombination_Homo sapiens_hsa03440	0.65564375
78	Fatty acid metabolism_Homo sapiens_hsa01212	0.64366852
79	Base excision repair_Homo sapiens_hsa03410	0.64176225
80	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.62469649
81	RNA transport_Homo sapiens_hsa03013	0.61736907
82	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.60290353
83	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.60108349
84	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.56955281
85	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.56636798
86	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.56441642
87	Folate biosynthesis_Homo sapiens_hsa00790	0.55495690
88	Fatty acid degradation_Homo sapiens_hsa00071	0.54060317
89	Mineral absorption_Homo sapiens_hsa04978	0.53427441
90	Salivary secretion_Homo sapiens_hsa04970	0.50709643
91	Oocyte meiosis_Homo sapiens_hsa04114	0.49957545
92	Ribosome_Homo sapiens_hsa03010	0.47560706
93	Vibrio cholerae infection_Homo sapiens_hsa05110	0.46096495
94	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.45540485
95	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.43473028
96	One carbon pool by folate_Homo sapiens_hsa00670	0.40488322
97	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.38285511
98	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.36016506
99	Pyrimidine metabolism_Homo sapiens_hsa00240	0.35898149
100	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.35327746

BMS1P12

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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