ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	neural tube formation (GO:0001841)	7.02493537
2	postsynaptic membrane organization (GO:0001941)	5.83523824
3	limb bud formation (GO:0060174)	5.11732152
4	piRNA metabolic process (GO:0034587)	4.90420900
5	presynaptic membrane assembly (GO:0097105)	4.73902640
6	negative regulation of heart rate (GO:0010459)	4.27578689
7	somite development (GO:0061053)	4.26980748
8	presynaptic membrane organization (GO:0097090)	3.92822688
9	DNA methylation involved in gamete generation (GO:0043046)	3.87406873
10	isoprenoid biosynthetic process (GO:0008299)	3.77459396
11	neuronal action potential propagation (GO:0019227)	3.77228021
12	peptidyl-arginine omega-N-methylation (GO:0035247)	3.72668291
13	GMP metabolic process (GO:0046037)	3.65038436
14	positive regulation of synapse assembly (GO:0051965)	3.64542158
15	histone arginine methylation (GO:0034969)	3.59457043
16	vocalization behavior (GO:0071625)	3.55710305
17	protein complex biogenesis (GO:0070271)	3.55320496
18	cornea development in camera-type eye (GO:0061303)	3.54618440
19	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	3.47272089
20	cholesterol biosynthetic process (GO:0006695)	3.45714789
21	pyrimidine nucleobase catabolic process (GO:0006208)	3.41683623
22	neuron cell-cell adhesion (GO:0007158)	3.41408644
23	cerebral cortex cell migration (GO:0021795)	3.40874090
24	glial cell proliferation (GO:0014009)	3.38942802
25	regulation of acyl-CoA biosynthetic process (GO:0050812)	3.38816663
26	positive regulation of male gonad development (GO:2000020)	3.38460360
27	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.37142193
28	regulation of cofactor metabolic process (GO:0051193)	3.33081603
29	regulation of coenzyme metabolic process (GO:0051196)	3.33081603
30	peptidyl-arginine methylation (GO:0018216)	3.32414906
31	peptidyl-arginine N-methylation (GO:0035246)	3.32414906
32	single strand break repair (GO:0000012)	3.26437051
33	embryonic epithelial tube formation (GO:0001838)	3.25462908
34	sterol biosynthetic process (GO:0016126)	3.23847594
35	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.21172595
36	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.21172595
37	NADH dehydrogenase complex assembly (GO:0010257)	3.21172595
38	sympathetic nervous system development (GO:0048485)	3.19853347
39	cerebral cortex radially oriented cell migration (GO:0021799)	3.19203458
40	cullin deneddylation (GO:0010388)	3.16282161
41	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.15469199
42	male meiosis I (GO:0007141)	3.15379146
43	lipid particle organization (GO:0034389)	3.13838464
44	monoubiquitinated protein deubiquitination (GO:0035520)	3.13835803
45	histone H4-K12 acetylation (GO:0043983)	3.11715107
46	epithelial tube formation (GO:0072175)	3.08154542
47	mitochondrial respiratory chain complex assembly (GO:0033108)	3.07218290
48	protein neddylation (GO:0045116)	3.07007114
49	indole-containing compound catabolic process (GO:0042436)	3.06301512
50	indolalkylamine catabolic process (GO:0046218)	3.06301512
51	tryptophan catabolic process (GO:0006569)	3.06301512
52	protein maturation by protein folding (GO:0022417)	3.04849317
53	axoneme assembly (GO:0035082)	3.01145109
54	DNA double-strand break processing (GO:0000729)	2.99653786
55	artery development (GO:0060840)	2.96402376
56	response to pheromone (GO:0019236)	2.96297931
57	response to lipoprotein particle (GO:0055094)	2.92653952
58	positive regulation of action potential (GO:0045760)	2.89298245
59	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.89130975
60	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	2.84598880
61	sequestering of actin monomers (GO:0042989)	2.83336239
62	lens morphogenesis in camera-type eye (GO:0002089)	2.76824694
63	righting reflex (GO:0060013)	2.76485585
64	polyamine metabolic process (GO:0006595)	2.76317206
65	replication fork processing (GO:0031297)	2.76168416
66	amine catabolic process (GO:0009310)	2.75059238
67	cellular biogenic amine catabolic process (GO:0042402)	2.75059238
68	regulation of male gonad development (GO:2000018)	2.74532507
69	cilium morphogenesis (GO:0060271)	2.74227423
70	positive regulation of vesicle fusion (GO:0031340)	2.73864034
71	intra-S DNA damage checkpoint (GO:0031573)	2.71774045
72	intraciliary transport (GO:0042073)	2.71678738
73	branched-chain amino acid catabolic process (GO:0009083)	2.71214954
74	auditory behavior (GO:0031223)	2.70476651
75	protein localization to synapse (GO:0035418)	2.69749898
76	synapse assembly (GO:0007416)	2.66162625
77	regulation of hippo signaling (GO:0035330)	2.66152631
78	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.65826358
79	forebrain neuron differentiation (GO:0021879)	2.65564726
80	amino acid salvage (GO:0043102)	2.64477216
81	L-methionine salvage (GO:0071267)	2.64477216
82	L-methionine biosynthetic process (GO:0071265)	2.64477216
83	synaptic vesicle maturation (GO:0016188)	2.62326697
84	clathrin coat assembly (GO:0048268)	2.60749198
85	peroxisome organization (GO:0007031)	2.57808739
86	seminiferous tubule development (GO:0072520)	2.56077055
87	nucleobase catabolic process (GO:0046113)	2.55402476
88	response to redox state (GO:0051775)	2.54434595
89	reflex (GO:0060004)	2.54146418
90	tongue development (GO:0043586)	2.53649053
91	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.53618120
92	snRNA transcription (GO:0009301)	2.52269849
93	regulation of respiratory system process (GO:0044065)	2.51957545
94	platelet dense granule organization (GO:0060155)	2.51150492
95	spinal cord development (GO:0021510)	2.49641066
96	protein deneddylation (GO:0000338)	2.48895110
97	sialylation (GO:0097503)	2.48081169
98	cilium movement (GO:0003341)	2.47511971
99	regulation of sulfur metabolic process (GO:0042762)	2.47160152
100	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.45259189

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	4.28684456
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.84313130
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.76989257
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	3.39908888
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.38542947
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.14051599
7	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.09472720
8	VDR_22108803_ChIP-Seq_LS180_Human	3.09441168
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.93091901
10	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.92214163
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.64801751
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.56047511
13	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.52645570
14	FUS_26573619_Chip-Seq_HEK293_Human	2.12729139
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.03389242
16	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.00091886
17	P300_19829295_ChIP-Seq_ESCs_Human	1.98422797
18	EWS_26573619_Chip-Seq_HEK293_Human	1.93519365
19	RNF2_27304074_Chip-Seq_NSC_Mouse	1.80328444
20	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.79907829
21	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.73421252
22	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.66393330
23	IRF1_19129219_ChIP-ChIP_H3396_Human	1.63985358
24	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.61632278
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.59123375
26	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.56940648
27	STAT3_23295773_ChIP-Seq_U87_Human	1.55269293
28	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.53536467
29	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.53132692
30	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.52154095
31	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.52115243
32	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.51352026
33	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.51254121
34	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.50790750
35	HTT_18923047_ChIP-ChIP_STHdh_Human	1.50050644
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.48641826
37	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.47943293
38	SMAD4_21799915_ChIP-Seq_A2780_Human	1.46129446
39	TP53_22573176_ChIP-Seq_HFKS_Human	1.45377748
40	ER_23166858_ChIP-Seq_MCF-7_Human	1.45237008
41	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.44289500
42	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.43922035
43	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.42295700
44	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.39787550
45	REST_21632747_ChIP-Seq_MESCs_Mouse	1.37586294
46	BCAT_22108803_ChIP-Seq_LS180_Human	1.37247289
47	AR_25329375_ChIP-Seq_VCAP_Human	1.36635944
48	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.36459259
49	JUN_21703547_ChIP-Seq_K562_Human	1.35379942
50	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.33135556
51	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.31078712
52	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.26894449
53	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.22990502
54	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.22990502
55	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.21102056
56	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.20242906
57	RUNX2_22187159_ChIP-Seq_PCA_Human	1.19690329
58	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.18104587
59	TCF4_23295773_ChIP-Seq_U87_Human	1.16813070
60	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.16263987
61	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.14382156
62	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.13999796
63	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.13700390
64	SOX2_19829295_ChIP-Seq_ESCs_Human	1.12293291
65	NANOG_19829295_ChIP-Seq_ESCs_Human	1.12293291
66	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.10860179
67	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.10584165
68	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.10531635
69	CBP_20019798_ChIP-Seq_JUKART_Human	1.10531635
70	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.09883449
71	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.08826059
72	MYC_18940864_ChIP-ChIP_HL60_Human	1.07703747
73	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.05236799
74	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.04817066
75	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.04682894
76	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	1.04660855
77	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.03105778
78	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.02627062
79	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02137832
80	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.00562526
81	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.98906245
82	P53_22387025_ChIP-Seq_ESCs_Mouse	0.98742739
83	AR_20517297_ChIP-Seq_VCAP_Human	0.98388760
84	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.97087970
85	ELK1_19687146_ChIP-ChIP_HELA_Human	0.96846748
86	KDM2B_26808549_Chip-Seq_REH_Human	0.95996248
87	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.95108056
88	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.94600203
89	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.93895212
90	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.92031792
91	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.90368728
92	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.89434694
93	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.89321041
94	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.89010192
95	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.88568453
96	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.88514430
97	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.87783524
98	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.87286512
99	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.87132781
100	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.86759571

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001529_abnormal_vocalization	3.70049850
2	MP0004147_increased_porphyrin_level	3.21636728
3	MP0005248_abnormal_Harderian_gland	2.99574988
4	MP0003122_maternal_imprinting	2.87165944
5	MP0001984_abnormal_olfaction	2.82512407
6	MP0002653_abnormal_ependyma_morphology	2.78782373
7	MP0006292_abnormal_olfactory_placode	2.77266131
8	MP0003880_abnormal_central_pattern	2.45844417
9	MP0006276_abnormal_autonomic_nervous	2.26658175
10	MP0005646_abnormal_pituitary_gland	2.24845631
11	MP0000566_synostosis	2.20892607
12	MP0005187_abnormal_penis_morphology	2.09834622
13	MP0000647_abnormal_sebaceous_gland	1.92358127
14	MP0008789_abnormal_olfactory_epithelium	1.86189871
15	MP0002938_white_spotting	1.86158368
16	MP0001486_abnormal_startle_reflex	1.83896088
17	MP0001293_anophthalmia	1.77565565
18	MP0003136_yellow_coat_color	1.73478807
19	MP0009046_muscle_twitch	1.72559715
20	MP0008877_abnormal_DNA_methylation	1.70210737
21	MP0004859_abnormal_synaptic_plasticity	1.67043050
22	MP0003567_abnormal_fetal_cardiomyocyte	1.65121783
23	MP0000383_abnormal_hair_follicle	1.63613474
24	MP0004133_heterotaxia	1.60828492
25	MP0006072_abnormal_retinal_apoptosis	1.58609511
26	MP0002638_abnormal_pupillary_reflex	1.55077240
27	MP0002102_abnormal_ear_morphology	1.55051560
28	MP0004142_abnormal_muscle_tone	1.55020161
29	MP0002751_abnormal_autonomic_nervous	1.53262768
30	MP0008058_abnormal_DNA_repair	1.51487118
31	MP0005499_abnormal_olfactory_system	1.51018368
32	MP0005394_taste/olfaction_phenotype	1.51018368
33	MP0003121_genomic_imprinting	1.48841118
34	MP0000778_abnormal_nervous_system	1.46733911
35	MP0003937_abnormal_limbs/digits/tail_de	1.40453633
36	MP0001299_abnormal_eye_distance/	1.39985996
37	MP0002184_abnormal_innervation	1.38998951
38	MP0003011_delayed_dark_adaptation	1.33989694
39	MP0000049_abnormal_middle_ear	1.33087959
40	MP0005551_abnormal_eye_electrophysiolog	1.32129974
41	MP0003938_abnormal_ear_development	1.28774481
42	MP0003755_abnormal_palate_morphology	1.28399366
43	MP0002572_abnormal_emotion/affect_behav	1.24865874
44	MP0003635_abnormal_synaptic_transmissio	1.20249403
45	MP0002736_abnormal_nociception_after	1.19960280
46	MP0002254_reproductive_system_inflammat	1.19558168
47	MP0009053_abnormal_anal_canal	1.17539012
48	MP0002233_abnormal_nose_morphology	1.16796251
49	MP0004270_analgesia	1.16047985
50	MP0003787_abnormal_imprinting	1.15945816
51	MP0002697_abnormal_eye_size	1.15473857
52	MP0002067_abnormal_sensory_capabilities	1.15004352
53	MP0006035_abnormal_mitochondrial_morpho	1.14746984
54	MP0004272_abnormal_basement_membrane	1.11566512
55	MP0000569_abnormal_digit_pigmentation	1.10917834
56	MP0002557_abnormal_social/conspecific_i	1.09594222
57	MP0002272_abnormal_nervous_system	1.08508575
58	MP0005195_abnormal_posterior_eye	1.07240814
59	MP0002089_abnormal_postnatal_growth/wei	1.06831479
60	MP0005171_absent_coat_pigmentation	1.06666890
61	MP0002282_abnormal_trachea_morphology	1.05606463
62	MP0002063_abnormal_learning/memory/cond	1.03923741
63	MP0003186_abnormal_redox_activity	1.03718859
64	MP0001968_abnormal_touch/_nociception	1.03583535
65	MP0002733_abnormal_thermal_nociception	1.02874520
66	MP0000579_abnormal_nail_morphology	1.02344185
67	MP0000613_abnormal_salivary_gland	1.02266266
68	MP0000358_abnormal_cell_content/	1.02082499
69	MP0001346_abnormal_lacrimal_gland	1.01936128
70	MP0002752_abnormal_somatic_nervous	1.01012348
71	MP0002177_abnormal_outer_ear	1.00958608
72	MP0010030_abnormal_orbit_morphology	1.00040862
73	MP0003385_abnormal_body_wall	0.96703810
74	MP0008995_early_reproductive_senescence	0.95661868
75	MP0005253_abnormal_eye_physiology	0.92644202
76	MP0000372_irregular_coat_pigmentation	0.92011942
77	MP0003646_muscle_fatigue	0.91618816
78	MP0003119_abnormal_digestive_system	0.91198401
79	MP0009745_abnormal_behavioral_response	0.89954963
80	MP0000026_abnormal_inner_ear	0.87854549
81	MP0005448_abnormal_energy_balance	0.87457052
82	MP0001502_abnormal_circadian_rhythm	0.86554611
83	MP0001970_abnormal_pain_threshold	0.86440737
84	MP0001286_abnormal_eye_development	0.85957343
85	MP0003861_abnormal_nervous_system	0.83790057
86	MP0000631_abnormal_neuroendocrine_gland	0.83641029
87	MP0002882_abnormal_neuron_morphology	0.81139033
88	MP0000955_abnormal_spinal_cord	0.80589540
89	MP0003718_maternal_effect	0.79988222
90	MP0002734_abnormal_mechanical_nocicepti	0.79293009
91	MP0001340_abnormal_eyelid_morphology	0.79236135
92	MP0000639_abnormal_adrenal_gland	0.78250595
93	MP0010678_abnormal_skin_adnexa	0.77771662
94	MP0003698_abnormal_male_reproductive	0.77554509
95	MP0002095_abnormal_skin_pigmentation	0.76944078
96	MP0002249_abnormal_larynx_morphology	0.76050202
97	MP0002064_seizures	0.74757748
98	MP0002152_abnormal_brain_morphology	0.74417822
99	MP0005408_hypopigmentation	0.74388033
100	MP0003315_abnormal_perineum_morphology	0.74098870

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Oligodactyly (hands) (HP:0001180)	4.36356038
2	Abnormal hair whorl (HP:0010721)	3.86119620
3	Oligodactyly (HP:0012165)	3.77772601
4	Drooling (HP:0002307)	3.58731148
5	Abnormal mitochondria in muscle tissue (HP:0008316)	3.38110340
6	Methylmalonic acidemia (HP:0002912)	3.34697634
7	True hermaphroditism (HP:0010459)	3.34357626
8	Excessive salivation (HP:0003781)	3.29517520
9	Medial flaring of the eyebrow (HP:0010747)	3.23076700
10	Lissencephaly (HP:0001339)	3.13464791
11	Acute necrotizing encephalopathy (HP:0006965)	3.08376693
12	Limb dystonia (HP:0002451)	2.91829228
13	Broad alveolar ridges (HP:0000187)	2.89571865
14	Abnormality of the phalanges of the hallux (HP:0010057)	2.77101677
15	Colon cancer (HP:0003003)	2.74430240
16	Split foot (HP:0001839)	2.71695167
17	Acute encephalopathy (HP:0006846)	2.69193680
18	Gait imbalance (HP:0002141)	2.66108452
19	Methylmalonic aciduria (HP:0012120)	2.65907287
20	Upper limb muscle weakness (HP:0003484)	2.57634480
21	Brushfield spots (HP:0001088)	2.55281646
22	Insidious onset (HP:0003587)	2.53137591
23	Termporal pattern (HP:0011008)	2.53137591
24	Febrile seizures (HP:0002373)	2.50731924
25	Abnormality of the labia minora (HP:0012880)	2.46279554
26	Impaired vibration sensation in the lower limbs (HP:0002166)	2.45074732
27	Hyperglycinemia (HP:0002154)	2.44057921
28	Molar tooth sign on MRI (HP:0002419)	2.43361459
29	Abnormality of midbrain morphology (HP:0002418)	2.43361459
30	Nephrogenic diabetes insipidus (HP:0009806)	2.42929693
31	Retinal dysplasia (HP:0007973)	2.40785839
32	Abnormality of the corticospinal tract (HP:0002492)	2.40119815
33	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.39404821
34	Congenital primary aphakia (HP:0007707)	2.38995029
35	Short tibia (HP:0005736)	2.37094393
36	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.36400189
37	Delayed gross motor development (HP:0002194)	2.36072846
38	Thyroid-stimulating hormone excess (HP:0002925)	2.35579026
39	Progressive macrocephaly (HP:0004481)	2.31710773
40	Hypoplastic iliac wings (HP:0002866)	2.31430674
41	White forelock (HP:0002211)	2.31101056
42	Labial hypoplasia (HP:0000066)	2.29836180
43	Hypoplastic pelvis (HP:0008839)	2.27658662
44	Supernumerary spleens (HP:0009799)	2.24042646
45	Pancreatic cysts (HP:0001737)	2.23583272
46	Gaze-evoked nystagmus (HP:0000640)	2.17577763
47	Ankle clonus (HP:0011448)	2.17019271
48	Abnormality of homocysteine metabolism (HP:0010919)	2.14886176
49	Homocystinuria (HP:0002156)	2.14886176
50	Polyphagia (HP:0002591)	2.14769668
51	Abnormality of the labia (HP:0000058)	2.14345162
52	Hypoplastic female external genitalia (HP:0012815)	2.09713120
53	Pancreatic fibrosis (HP:0100732)	2.09669405
54	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.09178974
55	Hyperglycinuria (HP:0003108)	2.07672681
56	Abnormal pupillary function (HP:0007686)	2.07233127
57	Specific learning disability (HP:0001328)	2.06214740
58	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.05135259
59	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.05135259
60	Type II lissencephaly (HP:0007260)	2.02880911
61	Abnormality of vitamin B metabolism (HP:0004340)	2.01801109
62	Poor coordination (HP:0002370)	1.98062982
63	Abnormality of the aortic arch (HP:0012303)	1.96494325
64	Patchy hypopigmentation of hair (HP:0011365)	1.96368950
65	Ulnar claw (HP:0001178)	1.95649846
66	Cortical dysplasia (HP:0002539)	1.94963488
67	Poor suck (HP:0002033)	1.94213626
68	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.92158145
69	Capillary hemangiomas (HP:0005306)	1.92067433
70	Nephronophthisis (HP:0000090)	1.91259005
71	Facial hemangioma (HP:0000329)	1.91165501
72	Action tremor (HP:0002345)	1.90804641
73	Impulsivity (HP:0100710)	1.89820427
74	Abnormality of the renal medulla (HP:0100957)	1.88726414
75	Abnormality of serine family amino acid metabolism (HP:0010894)	1.88580233
76	Abnormality of glycine metabolism (HP:0010895)	1.88580233
77	Preaxial foot polydactyly (HP:0001841)	1.87066778
78	Optic nerve hypoplasia (HP:0000609)	1.86795486
79	Pachygyria (HP:0001302)	1.86639203
80	Urinary bladder sphincter dysfunction (HP:0002839)	1.85744605
81	Abnormality of the fovea (HP:0000493)	1.85058100
82	Postaxial hand polydactyly (HP:0001162)	1.83873194
83	Vaginal atresia (HP:0000148)	1.83856087
84	Genital tract atresia (HP:0001827)	1.83732249
85	Spastic gait (HP:0002064)	1.83123432
86	Tachypnea (HP:0002789)	1.82701489
87	Hand muscle atrophy (HP:0009130)	1.80301192
88	Abnormality of salivation (HP:0100755)	1.80166581
89	Adrenal hypoplasia (HP:0000835)	1.79966748
90	Vitreoretinal degeneration (HP:0000655)	1.79619419
91	Wide intermamillary distance (HP:0006610)	1.79418643
92	Choroideremia (HP:0001139)	1.79176859
93	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.78985710
94	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.78288433
95	Fibular hypoplasia (HP:0003038)	1.77510018
96	Severe Myopia (HP:0011003)	1.77406061
97	Abnormality of methionine metabolism (HP:0010901)	1.76208982
98	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.76005486
99	Abnormality of the lower motor neuron (HP:0002366)	1.75559279
100	Mitochondrial inheritance (HP:0001427)	1.73118553

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.98823248
2	MAP3K4	2.98582165
3	MAP2K7	2.88818837
4	PAK3	2.85939358
5	CASK	2.81690953
6	PLK2	2.41231161
7	WNK3	2.39524445
8	MARK1	2.29701321
9	TNIK	2.09629700
10	TAOK1	2.08903679
11	MINK1	2.06874179
12	PINK1	1.86094919
13	EPHB2	1.85553387
14	EPHA4	1.85525463
15	MAPK13	1.82106411
16	PNCK	1.78661648
17	MKNK2	1.78411731
18	PAK6	1.75330182
19	ERBB3	1.71949849
20	CSNK1G1	1.70479421
21	STK3	1.65713685
22	TAOK3	1.64671532
23	CSNK1G3	1.61542517
24	CSNK1G2	1.57848377
25	ADRBK2	1.57769892
26	MKNK1	1.55204351
27	NEK2	1.53724393
28	SIK2	1.51189310
29	TRIM28	1.45316843
30	BCR	1.40603751
31	DYRK3	1.39075153
32	BMPR1B	1.38517032
33	STK16	1.37213650
34	PRKCG	1.35184495
35	KSR1	1.32776036
36	CSNK1A1L	1.23973976
37	INSRR	1.20274747
38	DYRK2	1.18862952
39	NTRK2	1.16396292
40	WEE1	1.14079208
41	FLT3	1.12271718
42	EIF2AK3	1.09372335
43	FRK	0.97764758
44	PRKCE	0.96762529
45	LIMK1	0.94415615
46	EIF2AK2	0.90047437
47	PTK2B	0.88739421
48	TNK2	0.88169953
49	GRK7	0.88169575
50	DAPK2	0.88165996
51	IRAK2	0.85875181
52	CSNK1A1	0.85543854
53	GRK1	0.85054777
54	CAMK2A	0.83001842
55	PHKG1	0.82840534
56	PHKG2	0.82840534
57	MAP2K4	0.78869461
58	ADRBK1	0.74123148
59	MST4	0.72687356
60	IRAK1	0.70132605
61	MAPK15	0.69378606
62	ROCK2	0.67871397
63	CDK19	0.66575639
64	TIE1	0.63276071
65	PKN2	0.61403449
66	CHUK	0.60460366
67	PRKCZ	0.59974760
68	NME1	0.58922933
69	BCKDK	0.58875563
70	BMX	0.55837445
71	FGFR1	0.55410934
72	DYRK1A	0.55371921
73	TGFBR1	0.54393957
74	PRKCQ	0.52845166
75	SRPK1	0.51627617
76	PRKG1	0.50264352
77	PKN1	0.49183585
78	RPS6KA5	0.48516614
79	MYLK	0.47540018
80	PRKACA	0.47510015
81	PRKCI	0.46914220
82	ROCK1	0.46253515
83	CAMK4	0.45879456
84	ACVR1B	0.45482496
85	RPS6KA4	0.45183143
86	RAF1	0.44665389
87	PIM2	0.41891710
88	FGR	0.38695152
89	NEK1	0.37744337
90	PRKCB	0.37158835
91	STK39	0.36089770
92	PLK3	0.35771334
93	CSNK1E	0.35431767
94	WNK4	0.35046434
95	PRKCA	0.34575695
96	GRK5	0.34568990
97	STK11	0.34545107
98	FER	0.34289598
99	LMTK2	0.34083924
100	TSSK6	0.33039525

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	3.93649225
2	Steroid biosynthesis_Homo sapiens_hsa00100	3.23274435
3	Nicotine addiction_Homo sapiens_hsa05033	2.78713787
4	Phototransduction_Homo sapiens_hsa04744	2.46585884
5	Propanoate metabolism_Homo sapiens_hsa00640	2.36374819
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.31351048
7	Non-homologous end-joining_Homo sapiens_hsa03450	2.15367235
8	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.11521796
9	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.05014169
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.03420781
11	GABAergic synapse_Homo sapiens_hsa04727	1.88561910
12	Peroxisome_Homo sapiens_hsa04146	1.80473176
13	Protein export_Homo sapiens_hsa03060	1.75643851
14	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.73244476
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.71238936
16	Butanoate metabolism_Homo sapiens_hsa00650	1.69187836
17	Parkinsons disease_Homo sapiens_hsa05012	1.66288854
18	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.64391941
19	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.63125859
20	Oxidative phosphorylation_Homo sapiens_hsa00190	1.53430833
21	Morphine addiction_Homo sapiens_hsa05032	1.49919297
22	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.43568915
23	Basal transcription factors_Homo sapiens_hsa03022	1.42897405
24	Arginine and proline metabolism_Homo sapiens_hsa00330	1.40318996
25	Regulation of autophagy_Homo sapiens_hsa04140	1.35966159
26	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.32933479
27	Pyruvate metabolism_Homo sapiens_hsa00620	1.31278357
28	Fatty acid elongation_Homo sapiens_hsa00062	1.29198287
29	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.27573653
30	Nitrogen metabolism_Homo sapiens_hsa00910	1.27489184
31	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.27062860
32	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.23207707
33	Taste transduction_Homo sapiens_hsa04742	1.20687675
34	Basal cell carcinoma_Homo sapiens_hsa05217	1.19946480
35	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.15329934
36	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.14341466
37	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.14273793
38	Olfactory transduction_Homo sapiens_hsa04740	1.11917102
39	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.09480981
40	Fatty acid metabolism_Homo sapiens_hsa01212	1.07967281
41	Dopaminergic synapse_Homo sapiens_hsa04728	1.07629897
42	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.04414172
43	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.01407630
44	Fat digestion and absorption_Homo sapiens_hsa04975	1.01327826
45	Huntingtons disease_Homo sapiens_hsa05016	1.00841826
46	Glutamatergic synapse_Homo sapiens_hsa04724	0.98498633
47	Serotonergic synapse_Homo sapiens_hsa04726	0.93576836
48	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.92152977
49	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.91783084
50	Cocaine addiction_Homo sapiens_hsa05030	0.91696224
51	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.90165228
52	Axon guidance_Homo sapiens_hsa04360	0.87008052
53	Hippo signaling pathway_Homo sapiens_hsa04390	0.86862440
54	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.85945744
55	ABC transporters_Homo sapiens_hsa02010	0.84890815
56	Circadian entrainment_Homo sapiens_hsa04713	0.82785685
57	Tryptophan metabolism_Homo sapiens_hsa00380	0.82755741
58	beta-Alanine metabolism_Homo sapiens_hsa00410	0.82420480
59	Retinol metabolism_Homo sapiens_hsa00830	0.78877991
60	Alzheimers disease_Homo sapiens_hsa05010	0.77218878
61	Metabolic pathways_Homo sapiens_hsa01100	0.74874099
62	Fanconi anemia pathway_Homo sapiens_hsa03460	0.74467571
63	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.73954065
64	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.70898523
65	Chemical carcinogenesis_Homo sapiens_hsa05204	0.70114310
66	Ether lipid metabolism_Homo sapiens_hsa00565	0.67910315
67	Insulin secretion_Homo sapiens_hsa04911	0.66159621
68	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.65297996
69	RNA degradation_Homo sapiens_hsa03018	0.62983060
70	Protein digestion and absorption_Homo sapiens_hsa04974	0.61966024
71	Linoleic acid metabolism_Homo sapiens_hsa00591	0.61153988
72	Oocyte meiosis_Homo sapiens_hsa04114	0.58132466
73	Glycerolipid metabolism_Homo sapiens_hsa00561	0.57750932
74	ECM-receptor interaction_Homo sapiens_hsa04512	0.57649043
75	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.56837592
76	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.56009273
77	Purine metabolism_Homo sapiens_hsa00230	0.55949501
78	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.55330027
79	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.53012177
80	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.52944238
81	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.51740592
82	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.51475547
83	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.50205504
84	Cardiac muscle contraction_Homo sapiens_hsa04260	0.50060109
85	Base excision repair_Homo sapiens_hsa03410	0.49983352
86	Gap junction_Homo sapiens_hsa04540	0.49333015
87	Circadian rhythm_Homo sapiens_hsa04710	0.48666615
88	Carbon metabolism_Homo sapiens_hsa01200	0.47450856
89	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.47157988
90	Wnt signaling pathway_Homo sapiens_hsa04310	0.46553435
91	Melanogenesis_Homo sapiens_hsa04916	0.46226134
92	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.45336240
93	Vibrio cholerae infection_Homo sapiens_hsa05110	0.45259941
94	Collecting duct acid secretion_Homo sapiens_hsa04966	0.43155779
95	Long-term depression_Homo sapiens_hsa04730	0.43025640
96	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.39612246
97	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.38558590
98	Salivary secretion_Homo sapiens_hsa04970	0.37660890
99	Calcium signaling pathway_Homo sapiens_hsa04020	0.36867878
100	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.36817617

BMS1P13

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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