ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.55773479
2	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	4.51920590
3	respiratory chain complex IV assembly (GO:0008535)	4.40260675
4	protein deneddylation (GO:0000338)	4.27557369
5	protein complex biogenesis (GO:0070271)	4.26414226
6	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	4.20837865
7	cullin deneddylation (GO:0010388)	4.15948517
8	mitochondrial respiratory chain complex assembly (GO:0033108)	4.06624853
9	cytochrome complex assembly (GO:0017004)	3.93163610
10	prenylation (GO:0097354)	3.90823303
11	protein prenylation (GO:0018342)	3.90823303
12	mannosylation (GO:0097502)	3.78575069
13	protein neddylation (GO:0045116)	3.78475364
14	ATP synthesis coupled proton transport (GO:0015986)	3.75935113
15	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.75935113
16	proteasome assembly (GO:0043248)	3.71024746
17	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.67214096
18	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.67214096
19	lactate metabolic process (GO:0006089)	3.62634906
20	NADH dehydrogenase complex assembly (GO:0010257)	3.62610992
21	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.62610992
22	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.62610992
23	respiratory electron transport chain (GO:0022904)	3.57979835
24	electron transport chain (GO:0022900)	3.57179573
25	DNA deamination (GO:0045006)	3.56912004
26	regulation of hypersensitivity (GO:0002883)	3.56302695
27	negative regulation of heart rate (GO:0010459)	3.53752604
28	adenosine metabolic process (GO:0046085)	3.51682809
29	tryptophan metabolic process (GO:0006568)	3.51620535
30	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.51501745
31	signal peptide processing (GO:0006465)	3.46578256
32	kynurenine metabolic process (GO:0070189)	3.32409833
33	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.30969859
34	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.30916278
35	glucosamine-containing compound catabolic process (GO:1901072)	3.30698202
36	water-soluble vitamin biosynthetic process (GO:0042364)	3.29853343
37	protein-cofactor linkage (GO:0018065)	3.27511230
38	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.24415090
39	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.23757863
40	protein targeting to Golgi (GO:0000042)	3.14252228
41	tryptophan catabolic process (GO:0006569)	3.06803085
42	indole-containing compound catabolic process (GO:0042436)	3.06803085
43	indolalkylamine catabolic process (GO:0046218)	3.06803085
44	indolalkylamine metabolic process (GO:0006586)	3.05203729
45	establishment of protein localization to Golgi (GO:0072600)	3.03948910
46	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	3.02959010
47	axoneme assembly (GO:0035082)	3.01813070
48	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.98492055
49	rRNA catabolic process (GO:0016075)	2.97576321
50	proton transport (GO:0015992)	2.96399448
51	hydrogen transport (GO:0006818)	2.96139035
52	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.93404872
53	inositol phosphate dephosphorylation (GO:0046855)	2.93404872
54	inositol phosphate catabolic process (GO:0071545)	2.87147698
55	succinate metabolic process (GO:0006105)	2.86633404
56	hydrogen ion transmembrane transport (GO:1902600)	2.84942668
57	regulation of cellular amino acid metabolic process (GO:0006521)	2.84868438
58	regulation of cilium movement (GO:0003352)	2.83048721
59	S-adenosylmethionine metabolic process (GO:0046500)	2.81997987
60	platelet dense granule organization (GO:0060155)	2.81929303
61	histone H2A ubiquitination (GO:0033522)	2.81913034
62	rRNA modification (GO:0000154)	2.80897434
63	chaperone-mediated protein transport (GO:0072321)	2.79931547
64	protein localization to Golgi apparatus (GO:0034067)	2.79765911
65	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.75380516
66	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.74188603
67	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.71953937
68	response to pheromone (GO:0019236)	2.70552931
69	regulation of action potential (GO:0098900)	2.69800631
70	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.69499450
71	termination of RNA polymerase III transcription (GO:0006386)	2.69499450
72	positive regulation of mitochondrial fission (GO:0090141)	2.69347495
73	GPI anchor metabolic process (GO:0006505)	2.66369334
74	peroxisome fission (GO:0016559)	2.65797364
75	preassembly of GPI anchor in ER membrane (GO:0016254)	2.65576288
76	regulation of oxidative phosphorylation (GO:0002082)	2.63635721
77	nucleotide transmembrane transport (GO:1901679)	2.63397340
78	positive regulation of mast cell activation involved in immune response (GO:0033008)	2.62552392
79	positive regulation of mast cell degranulation (GO:0043306)	2.62552392
80	amine catabolic process (GO:0009310)	2.61577888
81	cellular biogenic amine catabolic process (GO:0042402)	2.61577888
82	tRNA modification (GO:0006400)	2.60871671
83	negative regulation of mast cell activation (GO:0033004)	2.59271690
84	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.58584599
85	regulation of mitochondrial translation (GO:0070129)	2.58210941
86	GPI anchor biosynthetic process (GO:0006506)	2.56840850
87	tRNA processing (GO:0008033)	2.56202102
88	amino acid salvage (GO:0043102)	2.53677101
89	L-methionine salvage (GO:0071267)	2.53677101
90	L-methionine biosynthetic process (GO:0071265)	2.53677101
91	negative regulation of membrane potential (GO:0045837)	2.52999518
92	mitochondrial calcium ion transport (GO:0006851)	2.52953741
93	mitochondrial calcium ion homeostasis (GO:0051560)	2.52460681
94	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.52271233
95	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.52271233
96	protein K6-linked ubiquitination (GO:0085020)	2.52093948
97	positive regulation of action potential (GO:0045760)	2.51948464
98	xenobiotic catabolic process (GO:0042178)	2.51787837
99	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	2.51224152
100	intracellular protein transmembrane import (GO:0044743)	2.49969057

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.89005249
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.50196032
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.36125557
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.29113896
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.08088073
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.99525655
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.93722415
8	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.88517968
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.56399181
10	VDR_23849224_ChIP-Seq_CD4+_Human	2.53128508
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.44087365
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.42722120
13	ELK1_19687146_ChIP-ChIP_HELA_Human	2.34356468
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.33573873
15	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.32168011
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.30949762
17	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.23398472
18	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.20646082
19	IGF1R_20145208_ChIP-Seq_DFB_Human	2.12344465
20	FUS_26573619_Chip-Seq_HEK293_Human	2.01233446
21	VDR_22108803_ChIP-Seq_LS180_Human	2.00380777
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.96329489
23	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.93014455
24	FOXP3_21729870_ChIP-Seq_TREG_Human	1.91863582
25	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.84368267
26	GBX2_23144817_ChIP-Seq_PC3_Human	1.68753403
27	IRF1_19129219_ChIP-ChIP_H3396_Human	1.63336284
28	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.61385837
29	EWS_26573619_Chip-Seq_HEK293_Human	1.59508771
30	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.56443632
31	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.56365070
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.55387806
33	TAF15_26573619_Chip-Seq_HEK293_Human	1.54992277
34	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.54264592
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.53414297
36	P300_19829295_ChIP-Seq_ESCs_Human	1.52321884
37	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.51095358
38	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.51095358
39	AR_20517297_ChIP-Seq_VCAP_Human	1.49746453
40	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.49289857
41	CBP_20019798_ChIP-Seq_JUKART_Human	1.47638324
42	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.47638324
43	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.47463068
44	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.42389438
45	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.41243357
46	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.41157189
47	NANOG_19829295_ChIP-Seq_ESCs_Human	1.40162292
48	SOX2_19829295_ChIP-Seq_ESCs_Human	1.40162292
49	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.38256805
50	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.36674887
51	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.35404376
52	ER_23166858_ChIP-Seq_MCF-7_Human	1.33286009
53	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.30216406
54	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.29500045
55	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.29167383
56	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.27049334
57	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.26359752
58	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.24942539
59	NCOR_22424771_ChIP-Seq_293T_Human	1.23462810
60	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.21528587
61	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.18398772
62	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.17750756
63	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.16472808
64	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.15392187
65	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.14880873
66	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13142863
67	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.09498621
68	BCAT_22108803_ChIP-Seq_LS180_Human	1.09244161
69	GATA3_26560356_Chip-Seq_TH2_Human	1.09076947
70	HTT_18923047_ChIP-ChIP_STHdh_Human	1.08805477
71	DCP1A_22483619_ChIP-Seq_HELA_Human	1.08271094
72	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.08182254
73	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.05788947
74	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.03703187
75	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.03233052
76	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.02230836
77	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.01925515
78	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.01043865
79	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.00904126
80	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.99744997
81	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.98892941
82	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.98529034
83	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.98151060
84	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.97430250
85	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.97399742
86	CDX2_22108803_ChIP-Seq_LS180_Human	0.96762557
87	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.96269154
88	P53_22387025_ChIP-Seq_ESCs_Mouse	0.95525752
89	GABP_19822575_ChIP-Seq_HepG2_Human	0.95067380
90	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.93779617
91	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.92855765
92	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.92495847
93	P300_18555785_Chip-Seq_ESCs_Mouse	0.92400255
94	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.92258811
95	AR_25329375_ChIP-Seq_VCAP_Human	0.91970322
96	ERG_20517297_ChIP-Seq_VCAP_Human	0.91918916
97	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.91629697
98	HOXB7_26014856_ChIP-Seq_BT474_Human	0.91443651
99	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.91393588
100	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.91065803

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	4.59852161
2	MP0002837_dystrophic_cardiac_calcinosis	3.17839790
3	MP0006072_abnormal_retinal_apoptosis	3.04645426
4	MP0002876_abnormal_thyroid_physiology	3.04159314
5	MP0008877_abnormal_DNA_methylation	2.98751777
6	MP0004147_increased_porphyrin_level	2.67893668
7	MP0002163_abnormal_gland_morphology	2.58055279
8	MP0000372_irregular_coat_pigmentation	2.42788696
9	MP0003786_premature_aging	2.37053560
10	MP0005379_endocrine/exocrine_gland_phen	2.33940061
11	MP0002102_abnormal_ear_morphology	2.32129810
12	MP0001984_abnormal_olfaction	2.24632571
13	MP0005367_renal/urinary_system_phenotyp	2.18087104
14	MP0000516_abnormal_urinary_system	2.18087104
15	MP0005084_abnormal_gallbladder_morpholo	2.17422455
16	MP0010386_abnormal_urinary_bladder	2.12382129
17	MP0003787_abnormal_imprinting	2.02157579
18	MP0001529_abnormal_vocalization	1.96082622
19	MP0008007_abnormal_cellular_replicative	1.88190725
20	MP0008875_abnormal_xenobiotic_pharmacok	1.88014064
21	MP0005646_abnormal_pituitary_gland	1.88000725
22	MP0001986_abnormal_taste_sensitivity	1.85002171
23	MP0003806_abnormal_nucleotide_metabolis	1.84923060
24	MP0005645_abnormal_hypothalamus_physiol	1.78681851
25	MP0005332_abnormal_amino_acid	1.73818281
26	MP0006036_abnormal_mitochondrial_physio	1.70111410
27	MP0005551_abnormal_eye_electrophysiolog	1.67775545
28	MP0009046_muscle_twitch	1.67101461
29	MP0008872_abnormal_physiological_respon	1.67095326
30	MP0005671_abnormal_response_to	1.57990355
31	MP0001968_abnormal_touch/_nociception	1.51172759
32	MP0002938_white_spotting	1.47576727
33	MP0003724_increased_susceptibility_to	1.45810702
34	MP0005253_abnormal_eye_physiology	1.44834438
35	MP0008995_early_reproductive_senescence	1.44325550
36	MP0001756_abnormal_urination	1.43661179
37	MP0000013_abnormal_adipose_tissue	1.40983764
38	MP0002638_abnormal_pupillary_reflex	1.38584094
39	MP0008789_abnormal_olfactory_epithelium	1.37500351
40	MP0001835_abnormal_antigen_presentation	1.37341796
41	MP0009780_abnormal_chondrocyte_physiolo	1.36435372
42	MP0005636_abnormal_mineral_homeostasis	1.33097496
43	MP0004043_abnormal_pH_regulation	1.28803425
44	MP0009745_abnormal_behavioral_response	1.28161210
45	MP0003011_delayed_dark_adaptation	1.26292704
46	MP0001501_abnormal_sleep_pattern	1.26193606
47	MP0001919_abnormal_reproductive_system	1.25007495
48	MP0004142_abnormal_muscle_tone	1.24714813
49	MP0006035_abnormal_mitochondrial_morpho	1.23874428
50	MP0001905_abnormal_dopamine_level	1.23071139
51	MP0000427_abnormal_hair_cycle	1.18899092
52	MP0003186_abnormal_redox_activity	1.18650071
53	MP0005499_abnormal_olfactory_system	1.17877856
54	MP0005394_taste/olfaction_phenotype	1.17877856
55	MP0002234_abnormal_pharynx_morphology	1.14374922
56	MP0005075_abnormal_melanosome_morpholog	1.13886952
57	MP0003880_abnormal_central_pattern	1.11874760
58	MP0002277_abnormal_respiratory_mucosa	1.11226935
59	MP0005389_reproductive_system_phenotype	1.10625487
60	MP0008058_abnormal_DNA_repair	1.09171069
61	MP0001873_stomach_inflammation	1.08660839
62	MP0002272_abnormal_nervous_system	1.07477456
63	MP0003718_maternal_effect	1.07472061
64	MP0009764_decreased_sensitivity_to	1.07328231
65	MP0008775_abnormal_heart_ventricle	1.06394840
66	MP0002736_abnormal_nociception_after	1.06164805
67	MP0006276_abnormal_autonomic_nervous	1.03212431
68	MP0002090_abnormal_vision	1.02897107
69	MP0002557_abnormal_social/conspecific_i	0.98443903
70	MP0002693_abnormal_pancreas_physiology	0.98209094
71	MP0005410_abnormal_fertilization	0.97324097
72	MP0001970_abnormal_pain_threshold	0.96170341
73	MP0001764_abnormal_homeostasis	0.94961217
74	MP0003121_genomic_imprinting	0.92741270
75	MP0004215_abnormal_myocardial_fiber	0.91523409
76	MP0009785_altered_susceptibility_to	0.87623732
77	MP0001486_abnormal_startle_reflex	0.83007268
78	MP0002572_abnormal_emotion/affect_behav	0.82752363
79	MP0005319_abnormal_enzyme/_coenzyme	0.82212168
80	MP0005248_abnormal_Harderian_gland	0.81162556
81	MP0002332_abnormal_exercise_endurance	0.80896014
82	MP0001765_abnormal_ion_homeostasis	0.80817868
83	MP0000631_abnormal_neuroendocrine_gland	0.79429206
84	MP0000465_gastrointestinal_hemorrhage	0.78518310
85	MP0005386_behavior/neurological_phenoty	0.75794247
86	MP0004924_abnormal_behavior	0.75794247
87	MP0002160_abnormal_reproductive_system	0.74862446
88	MP0005365_abnormal_bile_salt	0.74242777
89	MP0002139_abnormal_hepatobiliary_system	0.71731182
90	MP0002735_abnormal_chemical_nociception	0.71550087
91	MP0005187_abnormal_penis_morphology	0.71312725
92	MP0003122_maternal_imprinting	0.70967862
93	MP0002148_abnormal_hypersensitivity_rea	0.70451005
94	MP0000647_abnormal_sebaceous_gland	0.69829888
95	MP0003137_abnormal_impulse_conducting	0.69322703
96	MP0010329_abnormal_lipoprotein_level	0.68402721
97	MP0001270_distended_abdomen	0.67314604
98	MP0005266_abnormal_metabolism	0.66495380
99	MP0009643_abnormal_urine_homeostasis	0.65715935
100	MP0001944_abnormal_pancreas_morphology	0.65443643

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hepatocellular necrosis (HP:0001404)	4.16425347
2	Mitochondrial inheritance (HP:0001427)	4.16321386
3	Acute necrotizing encephalopathy (HP:0006965)	4.08679100
4	Hypothermia (HP:0002045)	4.06473272
5	Increased CSF lactate (HP:0002490)	4.02913265
6	Hepatic necrosis (HP:0002605)	3.87130452
7	3-Methylglutaconic aciduria (HP:0003535)	3.83557471
8	Progressive macrocephaly (HP:0004481)	3.73690992
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.71240931
10	Increased hepatocellular lipid droplets (HP:0006565)	3.63971549
11	Congenital, generalized hypertrichosis (HP:0004540)	3.63081335
12	Lipid accumulation in hepatocytes (HP:0006561)	3.57537440
13	Acute encephalopathy (HP:0006846)	3.51673832
14	Delayed CNS myelination (HP:0002188)	3.48052696
15	Pancreatic cysts (HP:0001737)	3.40382408
16	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.31947764
17	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.31947764
18	Renal Fanconi syndrome (HP:0001994)	3.14233272
19	Abolished electroretinogram (ERG) (HP:0000550)	3.02618517
20	Increased serum lactate (HP:0002151)	3.02041793
21	Bile duct proliferation (HP:0001408)	2.81198063
22	Abnormal biliary tract physiology (HP:0012439)	2.81198063
23	Lactic acidosis (HP:0003128)	2.73555256
24	Medial flaring of the eyebrow (HP:0010747)	2.67529394
25	Aplasia/hypoplasia of the uterus (HP:0008684)	2.65128598
26	Cerebral edema (HP:0002181)	2.62425851
27	Pancreatic fibrosis (HP:0100732)	2.61124128
28	Exertional dyspnea (HP:0002875)	2.58311106
29	Methylmalonic acidemia (HP:0002912)	2.56999672
30	Optic disc pallor (HP:0000543)	2.48040594
31	Increased intramyocellular lipid droplets (HP:0012240)	2.47775933
32	Generalized aminoaciduria (HP:0002909)	2.47613935
33	Ketoacidosis (HP:0001993)	2.45929654
34	Nephronophthisis (HP:0000090)	2.44170926
35	Abnormality of the renal cortex (HP:0011035)	2.37510396
36	Congenital stationary night blindness (HP:0007642)	2.37407547
37	IgG deficiency (HP:0004315)	2.32076387
38	Congenital primary aphakia (HP:0007707)	2.30790586
39	Respiratory failure (HP:0002878)	2.26561571
40	True hermaphroditism (HP:0010459)	2.25639686
41	Gait imbalance (HP:0002141)	2.23373892
42	Keratoconus (HP:0000563)	2.21761446
43	Increased corneal curvature (HP:0100692)	2.21761446
44	Ketosis (HP:0001946)	2.21292137
45	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.19603163
46	Pendular nystagmus (HP:0012043)	2.14714134
47	Abnormality of midbrain morphology (HP:0002418)	2.14011617
48	Molar tooth sign on MRI (HP:0002419)	2.14011617
49	Increased muscle lipid content (HP:0009058)	2.13467979
50	Type I transferrin isoform profile (HP:0003642)	2.11321335
51	Abnormal drinking behavior (HP:0030082)	2.10549657
52	Polydipsia (HP:0001959)	2.10549657
53	Nephrogenic diabetes insipidus (HP:0009806)	2.10311302
54	Glycosuria (HP:0003076)	2.07112319
55	Abnormality of urine glucose concentration (HP:0011016)	2.07112319
56	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.02926337
57	Methylmalonic aciduria (HP:0012120)	2.02818317
58	Abnormality of the renal medulla (HP:0100957)	2.02815884
59	Renal cortical cysts (HP:0000803)	1.99819392
60	Hypoalbuminemia (HP:0003073)	1.99253626
61	Abnormal albumin level (HP:0012116)	1.99253626
62	Large for gestational age (HP:0001520)	1.95682007
63	Agitation (HP:0000713)	1.95639431
64	Abnormality of vitamin B metabolism (HP:0004340)	1.94182416
65	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.94123144
66	Tongue fasciculations (HP:0001308)	1.93661023
67	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.93431077
68	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.92385725
69	Abnormal protein glycosylation (HP:0012346)	1.92321486
70	Abnormal glycosylation (HP:0012345)	1.92321486
71	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.92321486
72	Abnormal protein N-linked glycosylation (HP:0012347)	1.92321486
73	Hypomagnesemia (HP:0002917)	1.92213298
74	Abnormality of renal resorption (HP:0011038)	1.92024221
75	Abnormality of alanine metabolism (HP:0010916)	1.85447818
76	Hyperalaninemia (HP:0003348)	1.85447818
77	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.85447818
78	Leukodystrophy (HP:0002415)	1.83836221
79	Neoplasm of the adrenal gland (HP:0100631)	1.83206783
80	Lethargy (HP:0001254)	1.81924890
81	Neoplasm of the adrenal cortex (HP:0100641)	1.81913118
82	Thyroiditis (HP:0100646)	1.81432536
83	Aplastic anemia (HP:0001915)	1.78932763
84	Hypoglycemic seizures (HP:0002173)	1.77585644
85	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.75877496
86	Progressive microcephaly (HP:0000253)	1.73464538
87	Exercise intolerance (HP:0003546)	1.73302644
88	Metaphyseal dysplasia (HP:0100255)	1.73200022
89	Hyperphosphaturia (HP:0003109)	1.72190371
90	Attenuation of retinal blood vessels (HP:0007843)	1.72179822
91	Cheilitis (HP:0100825)	1.72068438
92	Hypoproteinemia (HP:0003075)	1.72039247
93	Hypoplasia of the pons (HP:0012110)	1.71785196
94	Hypoplasia of the uterus (HP:0000013)	1.69133603
95	CNS demyelination (HP:0007305)	1.68884162
96	Gaze-evoked nystagmus (HP:0000640)	1.68795362
97	Colon cancer (HP:0003003)	1.66799167
98	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.65335318
99	Abnormality of the pons (HP:0007361)	1.64544190
100	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.64244667

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.34985198
2	FRK	3.66867702
3	TXK	3.50732930
4	NUAK1	3.26733257
5	TAOK3	2.40590171
6	ACVR1B	2.39044867
7	WNK3	2.23114230
8	TIE1	2.18580202
9	MAP3K4	2.15956135
10	CDK19	2.13594028
11	GRK1	2.09064483
12	ZAK	2.06522946
13	TLK1	2.06276419
14	FLT3	1.92929271
15	SRPK1	1.81893099
16	MST4	1.78143196
17	BCKDK	1.72439855
18	MAP3K12	1.67106417
19	CSNK1G2	1.59663619
20	ERBB3	1.59236218
21	BCR	1.58780213
22	ADRBK2	1.56740430
23	PHKG1	1.55500698
24	PHKG2	1.55500698
25	CSNK1G3	1.51061760
26	BRD4	1.48532465
27	PLK2	1.47014928
28	TRIM28	1.46901598
29	INSRR	1.46430513
30	STK24	1.43288991
31	EIF2AK3	1.41026627
32	BMPR1B	1.39143837
33	BMPR2	1.33514642
34	CSNK1G1	1.28537682
35	STK38L	1.22521040
36	OXSR1	1.21054415
37	MAP2K6	1.20232734
38	MAPK13	1.18141245
39	EIF2AK1	1.17740465
40	CSNK1A1L	1.16718846
41	VRK2	1.16651859
42	MAP3K14	1.15357461
43	PLK3	1.01536264
44	MAP2K7	0.98812802
45	KIT	0.97654006
46	TSSK6	0.91913137
47	IKBKB	0.88946196
48	PRKCE	0.88164311
49	MYLK	0.88012347
50	NME1	0.86635139
51	NEK1	0.81770185
52	LIMK1	0.80242821
53	BUB1	0.79796434
54	DYRK2	0.79110352
55	PINK1	0.77228770
56	TNK2	0.73928217
57	VRK1	0.73436513
58	CDK8	0.69266680
59	FER	0.67094883
60	PAK3	0.66294217
61	DAPK1	0.65877621
62	PRKCI	0.65615109
63	FES	0.59027752
64	CDK3	0.58275736
65	CSNK1A1	0.57724125
66	TGFBR1	0.57244927
67	IRAK4	0.56695960
68	WNK4	0.56650752
69	LYN	0.51056605
70	STK16	0.50474806
71	RPS6KA5	0.49872257
72	PRKCG	0.49512435
73	CSF1R	0.46297979
74	TEC	0.45047904
75	PRKACB	0.45023488
76	PRKD3	0.44307899
77	EPHA3	0.43595515
78	EGFR	0.43558050
79	CSNK1D	0.43145722
80	FGFR2	0.42812640
81	TESK1	0.42017284
82	SIK2	0.41158124
83	PLK4	0.40318559
84	NTRK3	0.40269790
85	PIK3CG	0.40021052
86	EPHA4	0.39288004
87	CHUK	0.39223704
88	AURKB	0.38993558
89	KDR	0.38263832
90	DAPK2	0.37980750
91	ABL1	0.37951160
92	CSNK2A1	0.37791973
93	EIF2AK2	0.35941197
94	CAMK2A	0.35003052
95	GRK6	0.34703299
96	PRKACA	0.34672971
97	PLK1	0.32270339
98	CSNK2A2	0.31999922
99	TBK1	0.31905682
100	PRKAA1	0.31405200

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	4.31609318
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.73144162
3	Proteasome_Homo sapiens_hsa03050	3.34466750
4	Asthma_Homo sapiens_hsa05310	3.04399073
5	Parkinsons disease_Homo sapiens_hsa05012	2.83635761
6	Type I diabetes mellitus_Homo sapiens_hsa04940	2.39221064
7	RNA polymerase_Homo sapiens_hsa03020	2.25183420
8	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.95336438
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.90727970
10	Alzheimers disease_Homo sapiens_hsa05010	1.85725755
11	Propanoate metabolism_Homo sapiens_hsa00640	1.80497063
12	Graft-versus-host disease_Homo sapiens_hsa05332	1.75824965
13	Phototransduction_Homo sapiens_hsa04744	1.73377864
14	Huntingtons disease_Homo sapiens_hsa05016	1.69449124
15	Homologous recombination_Homo sapiens_hsa03440	1.68497595
16	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.64621435
17	Allograft rejection_Homo sapiens_hsa05330	1.63084398
18	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.62938105
19	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.62075269
20	Fatty acid elongation_Homo sapiens_hsa00062	1.59370400
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.58231887
22	RNA degradation_Homo sapiens_hsa03018	1.54948980
23	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.53458688
24	Sulfur metabolism_Homo sapiens_hsa00920	1.50478327
25	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.49489805
26	Butanoate metabolism_Homo sapiens_hsa00650	1.48489761
27	Rheumatoid arthritis_Homo sapiens_hsa05323	1.42945003
28	Collecting duct acid secretion_Homo sapiens_hsa04966	1.39368151
29	One carbon pool by folate_Homo sapiens_hsa00670	1.33933261
30	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.28655592
31	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.26418514
32	Regulation of autophagy_Homo sapiens_hsa04140	1.24993703
33	Peroxisome_Homo sapiens_hsa04146	1.24801413
34	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.20446193
35	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.19370104
36	Basal transcription factors_Homo sapiens_hsa03022	1.18685676
37	Selenocompound metabolism_Homo sapiens_hsa00450	1.18467697
38	Tryptophan metabolism_Homo sapiens_hsa00380	1.17202193
39	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.15207891
40	Mismatch repair_Homo sapiens_hsa03430	1.13165233
41	Cardiac muscle contraction_Homo sapiens_hsa04260	1.09766713
42	Fanconi anemia pathway_Homo sapiens_hsa03460	1.09637519
43	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.08582476
44	beta-Alanine metabolism_Homo sapiens_hsa00410	1.06558119
45	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.05068628
46	Pyrimidine metabolism_Homo sapiens_hsa00240	0.98713044
47	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.95392024
48	Antigen processing and presentation_Homo sapiens_hsa04612	0.93154066
49	Purine metabolism_Homo sapiens_hsa00230	0.91986525
50	Linoleic acid metabolism_Homo sapiens_hsa00591	0.88594538
51	Ether lipid metabolism_Homo sapiens_hsa00565	0.87897127
52	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.87549165
53	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.84330799
54	Ribosome_Homo sapiens_hsa03010	0.83254897
55	Non-homologous end-joining_Homo sapiens_hsa03450	0.81149243
56	Nicotine addiction_Homo sapiens_hsa05033	0.80519099
57	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.79799927
58	Caffeine metabolism_Homo sapiens_hsa00232	0.76881940
59	RNA transport_Homo sapiens_hsa03013	0.75589868
60	Steroid biosynthesis_Homo sapiens_hsa00100	0.75502626
61	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.73677129
62	Base excision repair_Homo sapiens_hsa03410	0.73079753
63	Nitrogen metabolism_Homo sapiens_hsa00910	0.72949250
64	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.70468883
65	Circadian rhythm_Homo sapiens_hsa04710	0.69158412
66	Metabolic pathways_Homo sapiens_hsa01100	0.69100107
67	Chemical carcinogenesis_Homo sapiens_hsa05204	0.67364915
68	Spliceosome_Homo sapiens_hsa03040	0.66423027
69	Nucleotide excision repair_Homo sapiens_hsa03420	0.65759657
70	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.63755043
71	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.58903471
72	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.57113766
73	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.56460364
74	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.56006116
75	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.55729210
76	Taste transduction_Homo sapiens_hsa04742	0.55414391
77	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.53905536
78	Vibrio cholerae infection_Homo sapiens_hsa05110	0.52362719
79	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.52086582
80	GABAergic synapse_Homo sapiens_hsa04727	0.50861633
81	Retinol metabolism_Homo sapiens_hsa00830	0.50798737
82	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.50642275
83	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.49238914
84	Insulin secretion_Homo sapiens_hsa04911	0.49035911
85	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.48611707
86	DNA replication_Homo sapiens_hsa03030	0.47999749
87	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.47525190
88	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.46943104
89	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.46011321
90	Legionellosis_Homo sapiens_hsa05134	0.41592489
91	Glutathione metabolism_Homo sapiens_hsa00480	0.41150032
92	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.40221572
93	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.40137040
94	Morphine addiction_Homo sapiens_hsa05032	0.40003105
95	Folate biosynthesis_Homo sapiens_hsa00790	0.39977118
96	Fatty acid metabolism_Homo sapiens_hsa01212	0.39595692
97	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.39578286
98	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.39166239
99	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.35400122
100	Mineral absorption_Homo sapiens_hsa04978	0.34554164

BMS1P15

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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