ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	tachykinin receptor signaling pathway (GO:0007217)	5.80730163
2	protein K11-linked deubiquitination (GO:0035871)	5.55413992
3	cilium or flagellum-dependent cell motility (GO:0001539)	5.00076706
4	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.99079799
5	piRNA metabolic process (GO:0034587)	4.79412468
6	indolalkylamine metabolic process (GO:0006586)	4.52621485
7	indole-containing compound catabolic process (GO:0042436)	4.35204653
8	indolalkylamine catabolic process (GO:0046218)	4.35204653
9	tryptophan catabolic process (GO:0006569)	4.35204653
10	photoreceptor cell maintenance (GO:0045494)	4.31428852
11	neural tube formation (GO:0001841)	4.22900657
12	response to pheromone (GO:0019236)	4.10544752
13	detection of light stimulus involved in sensory perception (GO:0050962)	3.95114560
14	detection of light stimulus involved in visual perception (GO:0050908)	3.95114560
15	cellular ketone body metabolic process (GO:0046950)	3.94124886
16	behavioral response to nicotine (GO:0035095)	3.84647670
17	DNA methylation involved in gamete generation (GO:0043046)	3.71839195
18	regulation of hippo signaling (GO:0035330)	3.66548673
19	reflex (GO:0060004)	3.65704588
20	ketone body metabolic process (GO:1902224)	3.60910959
21	protein K48-linked deubiquitination (GO:0071108)	3.59231149
22	tryptophan metabolic process (GO:0006568)	3.54153089
23	signal peptide processing (GO:0006465)	3.51821651
24	regulation of meiosis I (GO:0060631)	3.43552273
25	regulation of pigment cell differentiation (GO:0050932)	3.41052623
26	indole-containing compound metabolic process (GO:0042430)	3.39966518
27	auditory receptor cell stereocilium organization (GO:0060088)	3.34476063
28	detection of mechanical stimulus involved in sensory perception (GO:0050974)	3.31947714
29	kynurenine metabolic process (GO:0070189)	3.30705330
30	sulfation (GO:0051923)	3.27388156
31	positive regulation of developmental pigmentation (GO:0048087)	3.26167460
32	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.22540780
33	gamma-aminobutyric acid transport (GO:0015812)	3.18380069
34	protein K63-linked deubiquitination (GO:0070536)	3.07852735
35	righting reflex (GO:0060013)	3.03428319
36	axoneme assembly (GO:0035082)	3.03332453
37	behavioral response to ethanol (GO:0048149)	3.03099325
38	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.03050974
39	gene silencing by RNA (GO:0031047)	3.01486713
40	flavonoid metabolic process (GO:0009812)	2.99838921
41	dopamine transport (GO:0015872)	2.99303645
42	proline transport (GO:0015824)	2.99125456
43	establishment of protein localization to Golgi (GO:0072600)	2.97620882
44	transmission of nerve impulse (GO:0019226)	2.96763817
45	retinal cone cell development (GO:0046549)	2.96684788
46	thyroid hormone metabolic process (GO:0042403)	2.95741564
47	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.93678368
48	cell wall macromolecule metabolic process (GO:0044036)	2.92801452
49	inner ear receptor stereocilium organization (GO:0060122)	2.90902484
50	regulation of sarcomere organization (GO:0060297)	2.89620773
51	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.87258607
52	cilium morphogenesis (GO:0060271)	2.87213926
53	neuronal action potential (GO:0019228)	2.85200010
54	DNA integration (GO:0015074)	2.84731367
55	synapsis (GO:0007129)	2.84146697
56	benzene-containing compound metabolic process (GO:0042537)	2.83509305
57	serotonin metabolic process (GO:0042428)	2.82979234
58	primary amino compound metabolic process (GO:1901160)	2.77503845
59	cellular biogenic amine catabolic process (GO:0042402)	2.76504491
60	amine catabolic process (GO:0009310)	2.76504491
61	startle response (GO:0001964)	2.76033460
62	negative regulation of mast cell activation (GO:0033004)	2.75896930
63	serotonin receptor signaling pathway (GO:0007210)	2.75581692
64	epithelial cilium movement (GO:0003351)	2.75431672
65	DNA double-strand break processing (GO:0000729)	2.73464550
66	central nervous system neuron axonogenesis (GO:0021955)	2.70519356
67	NAD biosynthetic process (GO:0009435)	2.69419851
68	protein localization to cilium (GO:0061512)	2.68399822
69	male meiosis I (GO:0007141)	2.67699424
70	reciprocal meiotic recombination (GO:0007131)	2.64535964
71	reciprocal DNA recombination (GO:0035825)	2.64535964
72	regulation of gene silencing by RNA (GO:0060966)	2.64323427
73	regulation of posttranscriptional gene silencing (GO:0060147)	2.64323427
74	regulation of gene silencing by miRNA (GO:0060964)	2.64323427
75	regulation of collateral sprouting (GO:0048670)	2.64051528
76	photoreceptor cell development (GO:0042461)	2.63852880
77	regulation of action potential (GO:0098900)	2.63637373
78	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.63141839
79	male meiosis (GO:0007140)	2.62884566
80	L-fucose catabolic process (GO:0042355)	2.62068706
81	fucose catabolic process (GO:0019317)	2.62068706
82	L-fucose metabolic process (GO:0042354)	2.62068706
83	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.61835918
84	multicellular organism reproduction (GO:0032504)	2.60646432
85	regulation of female gonad development (GO:2000194)	2.57784598
86	protein-chromophore linkage (GO:0018298)	2.56560524
87	cilium movement (GO:0003341)	2.56527354
88	methionine biosynthetic process (GO:0009086)	2.56073744
89	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.55762286
90	visual perception (GO:0007601)	2.55248520
91	cilium assembly (GO:0042384)	2.55121153
92	cilium organization (GO:0044782)	2.55053805
93	double-strand break repair via homologous recombination (GO:0000724)	2.53664625
94	recombinational repair (GO:0000725)	2.53583624
95	sensory perception of light stimulus (GO:0050953)	2.52788112
96	protein polyglutamylation (GO:0018095)	2.52684208
97	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.52567325
98	xenobiotic catabolic process (GO:0042178)	2.51445722
99	regulation of cilium movement (GO:0003352)	2.50590725
100	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	2.49491683

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.85367358
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.47472246
3	VDR_22108803_ChIP-Seq_LS180_Human	3.17215800
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.93344451
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.75962113
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.62953656
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.59727222
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.50794727
9	EZH2_22144423_ChIP-Seq_EOC_Human	2.44290712
10	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.41473628
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.37583688
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.34577277
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.19267315
14	FUS_26573619_Chip-Seq_HEK293_Human	2.16454988
15	P300_19829295_ChIP-Seq_ESCs_Human	2.15689261
16	ER_23166858_ChIP-Seq_MCF-7_Human	2.14888569
17	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.06928854
18	EWS_26573619_Chip-Seq_HEK293_Human	1.99495122
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.99067185
20	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.96288632
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.96020528
22	STAT3_23295773_ChIP-Seq_U87_Human	1.93793904
23	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.91593200
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.88659813
25	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.82984900
26	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.77983558
27	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.75781278
28	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.75169583
29	CBP_20019798_ChIP-Seq_JUKART_Human	1.74552580
30	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.74552580
31	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.74132214
32	BCAT_22108803_ChIP-Seq_LS180_Human	1.69836531
33	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.66092730
34	TCF4_23295773_ChIP-Seq_U87_Human	1.66068266
35	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.55970187
36	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.53948144
37	AR_25329375_ChIP-Seq_VCAP_Human	1.52138839
38	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.51234185
39	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.50929019
40	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.49898582
41	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.48366100
42	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.45186983
43	AR_21572438_ChIP-Seq_LNCaP_Human	1.45148886
44	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.45122395
45	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.42729704
46	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.42075776
47	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.41661987
48	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.39977323
49	TCF4_22108803_ChIP-Seq_LS180_Human	1.38967348
50	TP53_16413492_ChIP-PET_HCT116_Human	1.38707489
51	RUNX2_22187159_ChIP-Seq_PCA_Human	1.37439541
52	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.34240328
53	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.34055941
54	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.33252327
55	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.33182520
56	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.32495120
57	NANOG_19829295_ChIP-Seq_ESCs_Human	1.32151913
58	SOX2_19829295_ChIP-Seq_ESCs_Human	1.32151913
59	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.30517310
60	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.28391236
61	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.26251905
62	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.26251905
63	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.25890417
64	TP53_22573176_ChIP-Seq_HFKS_Human	1.25380611
65	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.24368123
66	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.23575856
67	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.22857543
68	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.22183504
69	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.21438208
70	CDX2_22108803_ChIP-Seq_LS180_Human	1.16923441
71	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.16780964
72	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.16309205
73	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.16099178
74	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.14498653
75	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.14172135
76	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.13131354
77	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.10529174
78	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.10496095
79	NCOR_22424771_ChIP-Seq_293T_Human	1.09438544
80	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08794018
81	P53_22387025_ChIP-Seq_ESCs_Mouse	1.07750317
82	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.06381083
83	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.06381083
84	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.06343643
85	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.04573222
86	DROSHA_22980978_ChIP-Seq_HELA_Human	1.03911512
87	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.01950534
88	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.01418304
89	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.99893175
90	REST_21632747_ChIP-Seq_MESCs_Mouse	0.99790820
91	RNF2_27304074_Chip-Seq_NSC_Mouse	0.99556239
92	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.99534090
93	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.99105665
94	KDM2B_26808549_Chip-Seq_REH_Human	0.98585249
95	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.98580116
96	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.97881302
97	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.96779261
98	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.96292560
99	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.95364177
100	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.94863463

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.84322922
2	MP0000569_abnormal_digit_pigmentation	3.41481825
3	MP0005551_abnormal_eye_electrophysiolog	2.83680505
4	MP0000372_irregular_coat_pigmentation	2.78258298
5	MP0003646_muscle_fatigue	2.74269660
6	MP0001968_abnormal_touch/_nociception	2.46369078
7	MP0002102_abnormal_ear_morphology	2.40230635
8	MP0003880_abnormal_central_pattern	2.37514692
9	MP0001501_abnormal_sleep_pattern	2.34682814
10	MP0008877_abnormal_DNA_methylation	2.32951492
11	MP0006276_abnormal_autonomic_nervous	2.29140576
12	MP0002736_abnormal_nociception_after	2.24760901
13	MP0001986_abnormal_taste_sensitivity	2.20462274
14	MP0003136_yellow_coat_color	2.19720628
15	MP0001984_abnormal_olfaction	2.14737672
16	MP0003950_abnormal_plasma_membrane	2.09599575
17	MP0009046_muscle_twitch	2.08751864
18	MP0004147_increased_porphyrin_level	2.05271115
19	MP0004043_abnormal_pH_regulation	2.02665693
20	MP0005253_abnormal_eye_physiology	1.93269983
21	MP0001486_abnormal_startle_reflex	1.91085829
22	MP0000427_abnormal_hair_cycle	1.89685955
23	MP0002138_abnormal_hepatobiliary_system	1.88815301
24	MP0010386_abnormal_urinary_bladder	1.76676059
25	MP0003045_fibrosis	1.76428984
26	MP0003183_abnormal_peptide_metabolism	1.73811296
27	MP0009745_abnormal_behavioral_response	1.73472885
28	MP0005646_abnormal_pituitary_gland	1.71210700
29	MP0001764_abnormal_homeostasis	1.67280963
30	MP0005645_abnormal_hypothalamus_physiol	1.60342467
31	MP0002735_abnormal_chemical_nociception	1.59555907
32	MP0002837_dystrophic_cardiac_calcinosis	1.54325253
33	MP0002272_abnormal_nervous_system	1.53238450
34	MP0001485_abnormal_pinna_reflex	1.51110324
35	MP0005410_abnormal_fertilization	1.48615523
36	MP0005171_absent_coat_pigmentation	1.47077003
37	MP0008995_early_reproductive_senescence	1.44168434
38	MP0005174_abnormal_tail_pigmentation	1.43302823
39	MP0005075_abnormal_melanosome_morpholog	1.39734925
40	MP0004142_abnormal_muscle_tone	1.35844555
41	MP0002876_abnormal_thyroid_physiology	1.30992777
42	MP0005377_hearing/vestibular/ear_phenot	1.30920563
43	MP0003878_abnormal_ear_physiology	1.30920563
44	MP0005670_abnormal_white_adipose	1.29938390
45	MP0008875_abnormal_xenobiotic_pharmacok	1.28306941
46	MP0003698_abnormal_male_reproductive	1.26403222
47	MP0008057_abnormal_DNA_replication	1.25517011
48	MP0008872_abnormal_physiological_respon	1.23912626
49	MP0002572_abnormal_emotion/affect_behav	1.23204230
50	MP0002064_seizures	1.22149716
51	MP0002160_abnormal_reproductive_system	1.20261793
52	MP0001970_abnormal_pain_threshold	1.19357880
53	MP0001529_abnormal_vocalization	1.13520450
54	MP0002067_abnormal_sensory_capabilities	1.13322177
55	MP0002168_other_aberrant_phenotype	1.11997101
56	MP0003787_abnormal_imprinting	1.07822701
57	MP0003635_abnormal_synaptic_transmissio	1.06540312
58	MP0002928_abnormal_bile_duct	1.06318007
59	MP0001929_abnormal_gametogenesis	1.05637223
60	MP0008058_abnormal_DNA_repair	1.05429719
61	MP0000015_abnormal_ear_pigmentation	1.04498068
62	MP0006072_abnormal_retinal_apoptosis	1.04275551
63	MP0000631_abnormal_neuroendocrine_gland	1.03876725
64	MP0003718_maternal_effect	1.03505584
65	MP0002095_abnormal_skin_pigmentation	1.03416178
66	MP0002229_neurodegeneration	1.02074288
67	MP0006054_spinal_hemorrhage	1.01804033
68	MP0005389_reproductive_system_phenotype	0.99013371
69	MP0002210_abnormal_sex_determination	0.98711765
70	MP0005647_abnormal_sex_gland	0.98369004
71	MP0000653_abnormal_sex_gland	0.94733390
72	MP0002734_abnormal_mechanical_nocicepti	0.94592915
73	MP0002733_abnormal_thermal_nociception	0.93624526
74	MP0004484_altered_response_of	0.93599013
75	MP0005266_abnormal_metabolism	0.93483326
76	MP0005310_abnormal_salivary_gland	0.92264340
77	MP0002234_abnormal_pharynx_morphology	0.92215434
78	MP0005395_other_phenotype	0.91072523
79	MP0001145_abnormal_male_reproductive	0.88546116
80	MP0009697_abnormal_copulation	0.87899399
81	MP0001664_abnormal_digestion	0.87179636
82	MP0003252_abnormal_bile_duct	0.85586964
83	MP0005085_abnormal_gallbladder_physiolo	0.85436861
84	MP0001324_abnormal_eye_pigmentation	0.85180780
85	MP0004924_abnormal_behavior	0.83553758
86	MP0005386_behavior/neurological_phenoty	0.83553758
87	MP0005195_abnormal_posterior_eye	0.83407337
88	MP0002557_abnormal_social/conspecific_i	0.82543688
89	MP0002752_abnormal_somatic_nervous	0.82328563
90	MP0001963_abnormal_hearing_physiology	0.82039681
91	MP0002063_abnormal_learning/memory/cond	0.81197806
92	MP0002751_abnormal_autonomic_nervous	0.81143648
93	MP0000383_abnormal_hair_follicle	0.78940335
94	MP0002332_abnormal_exercise_endurance	0.77870247
95	MP0000371_diluted_coat_color	0.77227187
96	MP0001905_abnormal_dopamine_level	0.76342341
97	MP0004145_abnormal_muscle_electrophysio	0.76294271
98	MP0005167_abnormal_blood-brain_barrier	0.76112900
99	MP0000230_abnormal_systemic_arterial	0.76091086
100	MP0005423_abnormal_somatic_nervous	0.75614639

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	5.00736988
2	True hermaphroditism (HP:0010459)	4.69246058
3	Pancreatic fibrosis (HP:0100732)	4.48010345
4	Attenuation of retinal blood vessels (HP:0007843)	4.36737050
5	Hyperventilation (HP:0002883)	4.13331380
6	Chronic hepatic failure (HP:0100626)	4.11827579
7	Abnormality of midbrain morphology (HP:0002418)	3.65300703
8	Molar tooth sign on MRI (HP:0002419)	3.65300703
9	Congenital stationary night blindness (HP:0007642)	3.56942559
10	Abolished electroretinogram (ERG) (HP:0000550)	3.51861930
11	Absent speech (HP:0001344)	3.41705403
12	Cystic liver disease (HP:0006706)	3.33008961
13	Gaze-evoked nystagmus (HP:0000640)	3.12631960
14	Nephronophthisis (HP:0000090)	3.11005259
15	Genetic anticipation (HP:0003743)	3.10068190
16	Abnormality of the renal cortex (HP:0011035)	2.99381987
17	Abnormality of the renal medulla (HP:0100957)	2.96661740
18	Type II lissencephaly (HP:0007260)	2.95858563
19	Medial flaring of the eyebrow (HP:0010747)	2.93835421
20	Abnormality of macular pigmentation (HP:0008002)	2.88271647
21	Retinal dysplasia (HP:0007973)	2.84841891
22	Inability to walk (HP:0002540)	2.84744639
23	Progressive cerebellar ataxia (HP:0002073)	2.82475715
24	Congenital sensorineural hearing impairment (HP:0008527)	2.82325676
25	Bony spicule pigmentary retinopathy (HP:0007737)	2.80206684
26	Clumsiness (HP:0002312)	2.78276329
27	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.75447433
28	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.74600229
29	Central scotoma (HP:0000603)	2.74564375
30	Decreased central vision (HP:0007663)	2.73673253
31	Cerebellar dysplasia (HP:0007033)	2.70193392
32	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.65032255
33	Progressive inability to walk (HP:0002505)	2.64631485
34	Protruding tongue (HP:0010808)	2.64313119
35	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.58634034
36	Absent/shortened dynein arms (HP:0200106)	2.58634034
37	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.56788440
38	Congenital primary aphakia (HP:0007707)	2.55374948
39	Gait imbalance (HP:0002141)	2.53314447
40	Anencephaly (HP:0002323)	2.52002546
41	Focal seizures (HP:0007359)	2.47250224
42	Congenital hepatic fibrosis (HP:0002612)	2.43401361
43	Increased corneal curvature (HP:0100692)	2.41982490
44	Keratoconus (HP:0000563)	2.41982490
45	Febrile seizures (HP:0002373)	2.36360034
46	Abnormal biliary tract physiology (HP:0012439)	2.35351751
47	Bile duct proliferation (HP:0001408)	2.35351751
48	Fair hair (HP:0002286)	2.35120165
49	Small hand (HP:0200055)	2.33668795
50	Sclerocornea (HP:0000647)	2.30956542
51	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.28909970
52	Furrowed tongue (HP:0000221)	2.28653267
53	Genital tract atresia (HP:0001827)	2.26432040
54	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.25417837
55	Renal cortical cysts (HP:0000803)	2.23575929
56	Male pseudohermaphroditism (HP:0000037)	2.23215234
57	Nephrogenic diabetes insipidus (HP:0009806)	2.20179665
58	Abnormal rod and cone electroretinograms (HP:0008323)	2.19008327
59	Dialeptic seizures (HP:0011146)	2.18924609
60	Methylmalonic aciduria (HP:0012120)	2.16794925
61	Abnormal ciliary motility (HP:0012262)	2.16761621
62	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.15431136
63	Postaxial foot polydactyly (HP:0001830)	2.15275987
64	Pendular nystagmus (HP:0012043)	2.13388690
65	Poor coordination (HP:0002370)	2.10413989
66	Vaginal atresia (HP:0000148)	2.10355561
67	Constricted visual fields (HP:0001133)	2.07868732
68	Focal motor seizures (HP:0011153)	2.07686234
69	Occipital encephalocele (HP:0002085)	2.06800976
70	Facial diplegia (HP:0001349)	2.06686720
71	Broad-based gait (HP:0002136)	2.04087386
72	Poikiloderma (HP:0001029)	2.01725644
73	Retinitis pigmentosa (HP:0000510)	2.00965216
74	Tubulointerstitial nephritis (HP:0001970)	2.00858935
75	Astigmatism (HP:0000483)	1.98635281
76	Abnormal protein glycosylation (HP:0012346)	1.98144627
77	Abnormal glycosylation (HP:0012345)	1.98144627
78	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.98144627
79	Abnormal protein N-linked glycosylation (HP:0012347)	1.98144627
80	Macular degeneration (HP:0000608)	1.97284229
81	Stomach cancer (HP:0012126)	1.97250728
82	Atonic seizures (HP:0010819)	1.90853856
83	Decreased circulating renin level (HP:0003351)	1.88084259
84	Hyperglycinemia (HP:0002154)	1.87528814
85	Scotoma (HP:0000575)	1.86996022
86	Type I transferrin isoform profile (HP:0003642)	1.86973380
87	Thyroid-stimulating hormone excess (HP:0002925)	1.84756666
88	Supernumerary spleens (HP:0009799)	1.84153118
89	Generalized hypopigmentation of hair (HP:0011358)	1.84063538
90	Gonadotropin excess (HP:0000837)	1.83748412
91	Abnormal respiratory motile cilium physiology (HP:0012261)	1.82823818
92	Optic nerve hypoplasia (HP:0000609)	1.82789549
93	Tubulointerstitial abnormality (HP:0001969)	1.82590471
94	Hypothermia (HP:0002045)	1.81793435
95	Thyroiditis (HP:0100646)	1.81677811
96	Hyperglycinuria (HP:0003108)	1.80807455
97	Methylmalonic acidemia (HP:0002912)	1.80748072
98	Photophobia (HP:0000613)	1.80148102
99	Sloping forehead (HP:0000340)	1.79634545
100	Ketoacidosis (HP:0001993)	1.78959329

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	8.51428573
2	PINK1	3.06384034
3	TAOK3	2.97353808
4	BMPR1B	2.70863578
5	WNK3	2.45220246
6	ADRBK2	2.39121870
7	ZAK	2.20948200
8	EIF2AK3	2.18247676
9	STK38L	2.06276693
10	ACVR1B	1.98646015
11	MAP4K2	1.95038472
12	NUAK1	1.88385338
13	LATS1	1.87033562
14	MAPK13	1.85004153
15	BCR	1.81877427
16	INSRR	1.80033971
17	TRIM28	1.71272905
18	CASK	1.68436842
19	PIK3CG	1.66160351
20	EPHA4	1.53344953
21	NTRK3	1.50685318
22	GRK1	1.46909611
23	MAP3K4	1.35496357
24	MUSK	1.23664820
25	OXSR1	1.20455951
26	ADRBK1	1.17690526
27	TXK	1.15689972
28	PLK2	1.06905165
29	TEC	1.05306873
30	TNK2	1.00407244
31	OBSCN	1.00327718
32	DAPK2	0.91418614
33	STK38	0.89038380
34	MKNK2	0.86892878
35	PRKCE	0.86616697
36	STK39	0.86616112
37	STK3	0.83597062
38	MARK1	0.80542479
39	PTK2B	0.80215649
40	CSNK1A1L	0.80063003
41	FER	0.77275539
42	KIT	0.76875866
43	ERBB3	0.71405290
44	CSNK1G2	0.70961092
45	TGFBR1	0.70862593
46	MKNK1	0.69064596
47	MAP2K7	0.68335994
48	BRSK2	0.67876498
49	KDR	0.62930142
50	CSNK1G1	0.62689424
51	TNIK	0.62608237
52	BCKDK	0.62391140
53	CAMK2A	0.62205320
54	MAP3K7	0.62135393
55	CSNK1G3	0.61124306
56	FLT3	0.60826830
57	PAK3	0.59310202
58	IRAK1	0.58879020
59	PKN1	0.58773425
60	MAP3K5	0.56168228
61	ITK	0.55953479
62	DYRK2	0.55706396
63	PLK4	0.55666599
64	MAPKAPK5	0.55207087
65	PIK3CA	0.53565393
66	PDK2	0.53240689
67	NEK1	0.52844475
68	PRKCG	0.52616242
69	GRK5	0.50101772
70	TLK1	0.46617552
71	PRKACB	0.46594415
72	MAPKAPK3	0.45384942
73	SGK2	0.45034783
74	TIE1	0.43688598
75	CSF1R	0.42949150
76	AKT3	0.41924248
77	PRKAA2	0.41304082
78	RPS6KA5	0.41094318
79	CSNK1A1	0.39523584
80	PRKCQ	0.38107202
81	RPS6KA4	0.37957224
82	MARK3	0.37449353
83	VRK1	0.36943113
84	CAMK1	0.36890733
85	SYK	0.36170773
86	NLK	0.36167659
87	FGFR2	0.35847297
88	CSNK1D	0.35452816
89	PRKACA	0.34705786
90	ATM	0.34353327
91	BTK	0.33762715
92	CAMKK2	0.32445494
93	MELK	0.31047705
94	CAMK4	0.30747242
95	CDK8	0.29303348
96	LYN	0.29025709
97	MINK1	0.28862821
98	ABL1	0.28594489
99	CCNB1	0.27418119
100	IGF1R	0.27228174

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.18162899
2	Butanoate metabolism_Homo sapiens_hsa00650	3.17456805
3	Nicotine addiction_Homo sapiens_hsa05033	3.01891616
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.77059052
5	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.75363465
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.44248177
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.31102741
8	ABC transporters_Homo sapiens_hsa02010	2.21728412
9	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.21512803
10	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.13733776
11	Homologous recombination_Homo sapiens_hsa03440	2.12004126
12	Selenocompound metabolism_Homo sapiens_hsa00450	2.09302125
13	Propanoate metabolism_Homo sapiens_hsa00640	1.99842498
14	Fanconi anemia pathway_Homo sapiens_hsa03460	1.98624597
15	Nitrogen metabolism_Homo sapiens_hsa00910	1.94752275
16	Taste transduction_Homo sapiens_hsa04742	1.94384431
17	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.93476313
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.85589016
19	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.83333814
20	Ether lipid metabolism_Homo sapiens_hsa00565	1.81315541
21	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.79530690
22	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.75843814
23	Olfactory transduction_Homo sapiens_hsa04740	1.73591140
24	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.66763740
25	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.65621832
26	Morphine addiction_Homo sapiens_hsa05032	1.53396958
27	Chemical carcinogenesis_Homo sapiens_hsa05204	1.44144289
28	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.41699102
29	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.30804157
30	Circadian entrainment_Homo sapiens_hsa04713	1.28344995
31	GABAergic synapse_Homo sapiens_hsa04727	1.26419480
32	Retinol metabolism_Homo sapiens_hsa00830	1.25069771
33	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.21281651
34	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.20651760
35	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.20475898
36	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.20361350
37	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.18245191
38	Calcium signaling pathway_Homo sapiens_hsa04020	1.16087329
39	Glutamatergic synapse_Homo sapiens_hsa04724	1.15130593
40	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.14243883
41	Salivary secretion_Homo sapiens_hsa04970	1.13329705
42	Regulation of autophagy_Homo sapiens_hsa04140	1.12688416
43	beta-Alanine metabolism_Homo sapiens_hsa00410	1.10681789
44	Serotonergic synapse_Homo sapiens_hsa04726	1.10671754
45	Non-homologous end-joining_Homo sapiens_hsa03450	0.98084729
46	Basal transcription factors_Homo sapiens_hsa03022	0.97016927
47	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.91164348
48	Glycerolipid metabolism_Homo sapiens_hsa00561	0.89744009
49	Circadian rhythm_Homo sapiens_hsa04710	0.88226328
50	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.87799575
51	Histidine metabolism_Homo sapiens_hsa00340	0.86169374
52	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.85700847
53	Peroxisome_Homo sapiens_hsa04146	0.85664615
54	Sphingolipid metabolism_Homo sapiens_hsa00600	0.84419381
55	Caffeine metabolism_Homo sapiens_hsa00232	0.84025051
56	RNA degradation_Homo sapiens_hsa03018	0.83617585
57	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.77872814
58	Long-term depression_Homo sapiens_hsa04730	0.71181310
59	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.68328900
60	RNA polymerase_Homo sapiens_hsa03020	0.68176284
61	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.65116140
62	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.63270078
63	One carbon pool by folate_Homo sapiens_hsa00670	0.62526165
64	Purine metabolism_Homo sapiens_hsa00230	0.62500435
65	Cholinergic synapse_Homo sapiens_hsa04725	0.61277213
66	Fatty acid degradation_Homo sapiens_hsa00071	0.58933141
67	Glutathione metabolism_Homo sapiens_hsa00480	0.58192934
68	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.57469721
69	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.55738918
70	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.54508707
71	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.50459565
72	Metabolic pathways_Homo sapiens_hsa01100	0.49388277
73	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.48585237
74	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.48063444
75	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.47389956
76	cAMP signaling pathway_Homo sapiens_hsa04024	0.46839065
77	Primary immunodeficiency_Homo sapiens_hsa05340	0.46290213
78	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.45401229
79	Fatty acid metabolism_Homo sapiens_hsa01212	0.45338732
80	Dopaminergic synapse_Homo sapiens_hsa04728	0.44334141
81	Insulin secretion_Homo sapiens_hsa04911	0.43584917
82	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.42909164
83	Fat digestion and absorption_Homo sapiens_hsa04975	0.41247317
84	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.40173805
85	Lysine degradation_Homo sapiens_hsa00310	0.38583427
86	Nucleotide excision repair_Homo sapiens_hsa03420	0.38019356
87	Renin secretion_Homo sapiens_hsa04924	0.36445582
88	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.35716463
89	Cocaine addiction_Homo sapiens_hsa05030	0.33905485
90	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.31735362
91	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.31195031
92	Graft-versus-host disease_Homo sapiens_hsa05332	0.29948095
93	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.29730802
94	Protein export_Homo sapiens_hsa03060	0.29421992
95	Gastric acid secretion_Homo sapiens_hsa04971	0.28181708
96	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.27555557
97	Asthma_Homo sapiens_hsa05310	0.24588267
98	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.24116651
99	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.23360906
100	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.22704465

BMS1P17

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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