ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	coenzyme catabolic process (GO:0009109)	6.71644816
2	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	6.42608337
3	cellular response to zinc ion (GO:0071294)	5.97818168
4	ADP metabolic process (GO:0046031)	5.62203045
5	regulation of autophagic vacuole assembly (GO:2000785)	5.35798480
6	positive regulation of catecholamine secretion (GO:0033605)	5.10159240
7	positive regulation of protein kinase C signaling (GO:0090037)	5.02819326
8	righting reflex (GO:0060013)	4.94236274
9	activation of protein kinase B activity (GO:0032148)	4.77239506
10	response to muscle activity (GO:0014850)	4.64738254
11	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	4.36124828
12	regulation of oxidative phosphorylation (GO:0002082)	4.33179088
13	multicellular organism reproduction (GO:0032504)	4.29391599
14	regulation of vacuole organization (GO:0044088)	4.29294519
15	nucleoside diphosphate phosphorylation (GO:0006165)	4.27510463
16	AMP metabolic process (GO:0046033)	4.18521147
17	energy homeostasis (GO:0097009)	4.12195582
18	presynaptic membrane assembly (GO:0097105)	4.03552930
19	regulation of oxidative stress-induced neuron death (GO:1903203)	4.00955333
20	muscle cell cellular homeostasis (GO:0046716)	3.96404291
21	regulation of phosphoprotein phosphatase activity (GO:0043666)	3.96194149
22	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	3.95570886
23	purine ribonucleoside diphosphate metabolic process (GO:0009179)	3.85665748
24	purine nucleoside diphosphate metabolic process (GO:0009135)	3.85665748
25	lactate metabolic process (GO:0006089)	3.79537775
26	xenobiotic catabolic process (GO:0042178)	3.70541160
27	cellular response to cadmium ion (GO:0071276)	3.69743108
28	regulation of acyl-CoA biosynthetic process (GO:0050812)	3.65118359
29	zinc ion homeostasis (GO:0055069)	3.58054314
30	mRNA cleavage (GO:0006379)	3.50952157
31	presynaptic membrane organization (GO:0097090)	3.48614235
32	glucosamine-containing compound catabolic process (GO:1901072)	3.45654464
33	regulation of coenzyme metabolic process (GO:0051196)	3.41775044
34	regulation of cofactor metabolic process (GO:0051193)	3.41775044
35	regulation of protein kinase C signaling (GO:0090036)	3.34979158
36	reflex (GO:0060004)	3.34284127
37	cofactor catabolic process (GO:0051187)	3.30457920
38	regulation of phospholipase A2 activity (GO:0032429)	3.28310492
39	fibroblast migration (GO:0010761)	3.26156921
40	epithelial cilium movement (GO:0003351)	3.21116367
41	TOR signaling (GO:0031929)	3.20087926
42	positive regulation of amine transport (GO:0051954)	3.17398300
43	DNA double-strand break processing (GO:0000729)	3.16458680
44	myofibril assembly (GO:0030239)	3.15232638
45	protein localization to cell surface (GO:0034394)	3.13671089
46	acrosome reaction (GO:0007340)	3.11249139
47	regulation of protein sumoylation (GO:0033233)	3.10247542
48	response to zinc ion (GO:0010043)	3.08278659
49	relaxation of smooth muscle (GO:0044557)	3.04808534
50	androgen biosynthetic process (GO:0006702)	3.03750710
51	kidney morphogenesis (GO:0060993)	3.01335750
52	cellular zinc ion homeostasis (GO:0006882)	3.00642950
53	regulation of cellular respiration (GO:0043457)	2.99902474
54	auditory behavior (GO:0031223)	2.99651601
55	negative regulation of hydrogen peroxide-induced cell death (GO:1903206)	2.94821480
56	mitochondrion morphogenesis (GO:0070584)	2.88516467
57	regulation of dopamine secretion (GO:0014059)	2.86697221
58	GTP biosynthetic process (GO:0006183)	2.86125605
59	tongue development (GO:0043586)	2.83913425
60	regulation of hydrogen peroxide-induced cell death (GO:1903205)	2.81870923
61	nucleoside diphosphate biosynthetic process (GO:0009133)	2.81707324
62	epithelial cell differentiation involved in kidney development (GO:0035850)	2.80615572
63	muscle fiber development (GO:0048747)	2.78536272
64	regulation of sulfur metabolic process (GO:0042762)	2.76630087
65	negative regulation of striated muscle cell apoptotic process (GO:0010664)	2.75901568
66	positive regulation of receptor internalization (GO:0002092)	2.75281897
67	single fertilization (GO:0007338)	2.74262461
68	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.73767192
69	pteridine-containing compound biosynthetic process (GO:0042559)	2.73563258
70	nitric oxide mediated signal transduction (GO:0007263)	2.73105256
71	ribonucleoside diphosphate metabolic process (GO:0009185)	2.72473698
72	sulfation (GO:0051923)	2.72152678
73	positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)	2.72102263
74	mesenchymal-epithelial cell signaling (GO:0060638)	2.71846767
75	peroxisome fission (GO:0016559)	2.71531059
76	regulation of relaxation of muscle (GO:1901077)	2.69158432
77	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.68147471
78	negative regulation of response to reactive oxygen species (GO:1901032)	2.67534246
79	sperm motility (GO:0030317)	2.64105535
80	motile cilium assembly (GO:0044458)	2.63565761
81	cellular response to toxic substance (GO:0097237)	2.63335980
82	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.62397243
83	cilium movement (GO:0003341)	2.62041493
84	DNA integration (GO:0015074)	2.61225826
85	detection of calcium ion (GO:0005513)	2.60197040
86	COPII vesicle coating (GO:0048208)	2.59719644
87	positive regulation of protein homodimerization activity (GO:0090073)	2.57734600
88	reproduction (GO:0000003)	2.57065477
89	postsynaptic membrane organization (GO:0001941)	2.56127071
90	zinc ion transmembrane transport (GO:0071577)	2.56122592
91	cGMP metabolic process (GO:0046068)	2.55075789
92	toxin metabolic process (GO:0009404)	2.53588949
93	nucleoside diphosphate metabolic process (GO:0009132)	2.52172416
94	prostate gland growth (GO:0060736)	2.51822215
95	startle response (GO:0001964)	2.51011184
96	alanine transport (GO:0032328)	2.46587419
97	cornea development in camera-type eye (GO:0061303)	2.45789629
98	glutamine family amino acid catabolic process (GO:0009065)	2.45709700
99	water-soluble vitamin biosynthetic process (GO:0042364)	2.44745971
100	left/right axis specification (GO:0070986)	2.43447733

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.09087126
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.98429046
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.67251904
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.57775203
5	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.69914411
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.48159957
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.30845946
8	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.07401837
9	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	12.7426683
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.97007061
11	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.92171761
12	VDR_22108803_ChIP-Seq_LS180_Human	1.89087505
13	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.81649436
14	P300_19829295_ChIP-Seq_ESCs_Human	1.75897797
15	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.60539775
16	FUS_26573619_Chip-Seq_HEK293_Human	1.58862106
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.56074565
18	IRF1_19129219_ChIP-ChIP_H3396_Human	1.51385539
19	EWS_26573619_Chip-Seq_HEK293_Human	1.49889787
20	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.47609647
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.43157172
22	SMAD4_21799915_ChIP-Seq_A2780_Human	1.40988637
23	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.37882952
24	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.36639824
25	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.36639824
26	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.36212867
27	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.35198362
28	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.35148840
29	RXR_22108803_ChIP-Seq_LS180_Human	1.34690358
30	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.30328342
31	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.26827216
32	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.26179202
33	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.26161282
34	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.25497519
35	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.24357297
36	AR_21572438_ChIP-Seq_LNCaP_Human	1.22961764
37	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.21395094
38	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.21137671
39	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.20571579
40	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.19868971
41	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.19012555
42	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.17980848
43	BCAT_22108803_ChIP-Seq_LS180_Human	1.17093609
44	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.15334913
45	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.11838626
46	RUNX2_22187159_ChIP-Seq_PCA_Human	1.10483477
47	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.09878592
48	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.08399900
49	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.08390906
50	TAF15_26573619_Chip-Seq_HEK293_Human	1.06832613
51	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.05939471
52	CBP_20019798_ChIP-Seq_JUKART_Human	1.05939471
53	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.05112167
54	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.04092607
55	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.01839550
56	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.01195201
57	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.00421141
58	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.00075667
59	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.99581166
60	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.98734033
61	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.98622750
62	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.98415482
63	AR_25329375_ChIP-Seq_VCAP_Human	0.98070348
64	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.96934849
65	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.96906373
66	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.96808995
67	STAT3_23295773_ChIP-Seq_U87_Human	0.96308501
68	TBL1_22424771_ChIP-Seq_293T_Human	0.95975092
69	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.95946325
70	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.94982677
71	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.94963903
72	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.94429516
73	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.93752286
74	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.93387984
75	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.92963358
76	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.92459738
77	SOX2_19829295_ChIP-Seq_ESCs_Human	0.92004588
78	NANOG_19829295_ChIP-Seq_ESCs_Human	0.92004588
79	MYC_18940864_ChIP-ChIP_HL60_Human	0.91559725
80	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.90027267
81	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.89522089
82	TCF4_23295773_ChIP-Seq_U87_Human	0.88559635
83	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.87620083
84	NANOG_20526341_ChIP-Seq_ESCs_Human	0.87396911
85	TCF4_22108803_ChIP-Seq_LS180_Human	0.85657935
86	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.85595808
87	TP53_18474530_ChIP-ChIP_U2OS_Human	0.85258926
88	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.85244378
89	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.84113766
90	CDX2_22108803_ChIP-Seq_LS180_Human	0.83907470
91	CBP_21632823_ChIP-Seq_H3396_Human	0.83065252
92	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.83058124
93	NCOR_22424771_ChIP-Seq_293T_Human	0.82059344
94	ERA_21632823_ChIP-Seq_H3396_Human	0.79256093
95	AHR_22903824_ChIP-Seq_MCF-7_Human	0.78279953
96	NFYB_21822215_ChIP-Seq_K562_Human	0.77333086
97	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.77108662
98	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.75944340
99	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.75853789
100	RNF2_27304074_Chip-Seq_NSC_Mouse	0.75588619

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	3.80526890
2	MP0003806_abnormal_nucleotide_metabolis	3.76535586
3	MP0000749_muscle_degeneration	3.74288802
4	MP0006072_abnormal_retinal_apoptosis	3.47874592
5	MP0002102_abnormal_ear_morphology	3.32100006
6	MP0009697_abnormal_copulation	3.00672619
7	MP0003315_abnormal_perineum_morphology	2.98145516
8	MP0008004_abnormal_stomach_pH	2.48752074
9	MP0009046_muscle_twitch	2.48205144
10	MP0005187_abnormal_penis_morphology	2.39266713
11	MP0003136_yellow_coat_color	2.19849657
12	MP0004272_abnormal_basement_membrane	2.16346576
13	MP0003195_calcinosis	2.15055896
14	MP0001529_abnormal_vocalization	2.08578307
15	MP0004084_abnormal_cardiac_muscle	2.08566613
16	MP0002132_abnormal_respiratory_system	2.01575061
17	MP0002160_abnormal_reproductive_system	1.97040721
18	MP0004510_myositis	1.93444083
19	MP0001984_abnormal_olfaction	1.92725089
20	MP0001905_abnormal_dopamine_level	1.88596799
21	MP0003879_abnormal_hair_cell	1.73876894
22	MP0005253_abnormal_eye_physiology	1.72070481
23	MP0005646_abnormal_pituitary_gland	1.62912966
24	MP0000372_irregular_coat_pigmentation	1.56887249
25	MP0004215_abnormal_myocardial_fiber	1.56835835
26	MP0006036_abnormal_mitochondrial_physio	1.53183535
27	MP0005410_abnormal_fertilization	1.51407220
28	MP0002108_abnormal_muscle_morphology	1.48339152
29	MP0009780_abnormal_chondrocyte_physiolo	1.48109419
30	MP0004145_abnormal_muscle_electrophysio	1.46853856
31	MP0010234_abnormal_vibrissa_follicle	1.45618378
32	MP0010368_abnormal_lymphatic_system	1.40632748
33	MP0005330_cardiomyopathy	1.40348356
34	MP0001664_abnormal_digestion	1.37639835
35	MP0004036_abnormal_muscle_relaxation	1.36635489
36	MP0000537_abnormal_urethra_morphology	1.36206120
37	MP0002139_abnormal_hepatobiliary_system	1.35283683
38	MP0002269_muscular_atrophy	1.32729191
39	MP0002295_abnormal_pulmonary_circulatio	1.28653756
40	MP0001944_abnormal_pancreas_morphology	1.28504705
41	MP0004142_abnormal_muscle_tone	1.23405654
42	MP0005389_reproductive_system_phenotype	1.21488312
43	MP0005551_abnormal_eye_electrophysiolog	1.20840787
44	MP0002693_abnormal_pancreas_physiology	1.20401120
45	MP0004859_abnormal_synaptic_plasticity	1.18484859
46	MP0002928_abnormal_bile_duct	1.15730069
47	MP0002736_abnormal_nociception_after	1.13740647
48	MP0000516_abnormal_urinary_system	1.12380841
49	MP0005367_renal/urinary_system_phenotyp	1.12380841
50	MP0005084_abnormal_gallbladder_morpholo	1.11529323
51	MP0001968_abnormal_touch/_nociception	1.11379090
52	MP0005623_abnormal_meninges_morphology	1.09737984
53	MP0001501_abnormal_sleep_pattern	1.09695651
54	MP0008995_early_reproductive_senescence	1.08785373
55	MP0003718_maternal_effect	1.08322951
56	MP0005620_abnormal_muscle_contractility	1.03883952
57	MP0001502_abnormal_circadian_rhythm	1.01891401
58	MP0000538_abnormal_urinary_bladder	1.01764240
59	MP0005394_taste/olfaction_phenotype	0.99903193
60	MP0005499_abnormal_olfactory_system	0.99903193
61	MP0002090_abnormal_vision	0.99640144
62	MP0003283_abnormal_digestive_organ	0.97692945
63	MP0000631_abnormal_neuroendocrine_gland	0.97311854
64	MP0008872_abnormal_physiological_respon	0.96721945
65	MP0001270_distended_abdomen	0.96705933
66	MP0001764_abnormal_homeostasis	0.96649233
67	MP0001919_abnormal_reproductive_system	0.96296754
68	MP0002751_abnormal_autonomic_nervous	0.95960548
69	MP0002638_abnormal_pupillary_reflex	0.95244500
70	MP0009250_abnormal_appendicular_skeleto	0.94379200
71	MP0001756_abnormal_urination	0.93718350
72	MP0003119_abnormal_digestive_system	0.91147595
73	MP0004085_abnormal_heartbeat	0.91136032
74	MP0005266_abnormal_metabolism	0.90107804
75	MP0003385_abnormal_body_wall	0.88662455
76	MP0002233_abnormal_nose_morphology	0.87294486
77	MP0001299_abnormal_eye_distance/	0.86742192
78	MP0010386_abnormal_urinary_bladder	0.85203660
79	MP0005220_abnormal_exocrine_pancreas	0.83134515
80	MP0008961_abnormal_basal_metabolism	0.82442761
81	MP0008775_abnormal_heart_ventricle	0.82197674
82	MP0002067_abnormal_sensory_capabilities	0.81854041
83	MP0001188_hyperpigmentation	0.81667507
84	MP0004742_abnormal_vestibular_system	0.80618417
85	MP0002272_abnormal_nervous_system	0.79296689
86	MP0005386_behavior/neurological_phenoty	0.78600707
87	MP0004924_abnormal_behavior	0.78600707
88	MP0002127_abnormal_cardiovascular_syste	0.78378815
89	MP0009745_abnormal_behavioral_response	0.78261211
90	MP0001486_abnormal_startle_reflex	0.77647007
91	MP0003635_abnormal_synaptic_transmissio	0.77537163
92	MP0003698_abnormal_male_reproductive	0.76376042
93	MP0003633_abnormal_nervous_system	0.75528611
94	MP0005385_cardiovascular_system_phenoty	0.74539894
95	MP0001544_abnormal_cardiovascular_syste	0.74539894
96	MP0006035_abnormal_mitochondrial_morpho	0.70570199
97	MP0000230_abnormal_systemic_arterial	0.69850066
98	MP0004484_altered_response_of	0.69831326
99	MP0005360_urolithiasis	0.69078813
100	MP0003137_abnormal_impulse_conducting	0.68922499

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Calf muscle hypertrophy (HP:0008981)	4.75907549
2	Clumsiness (HP:0002312)	4.73513257
3	Muscle hypertrophy of the lower extremities (HP:0008968)	4.19882287
4	Abnormality of the calf musculature (HP:0001430)	4.04646650
5	Reduced antithrombin III activity (HP:0001976)	3.83806568
6	Abnormality of the shoulder girdle musculature (HP:0001435)	3.60143293
7	Exercise-induced muscle cramps (HP:0003710)	3.52861741
8	Proximal amyotrophy (HP:0007126)	3.44045244
9	Fibular aplasia (HP:0002990)	3.25740865
10	Large for gestational age (HP:0001520)	3.21598193
11	Hyperinsulinemic hypoglycemia (HP:0000825)	3.20207462
12	Pancreatic fibrosis (HP:0100732)	3.16686761
13	Scapular winging (HP:0003691)	3.14575129
14	Abnormality of the columella (HP:0009929)	3.08138989
15	Hyperglycinemia (HP:0002154)	3.04622226
16	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.03668626
17	Resting tremor (HP:0002322)	2.89196274
18	Hyporeflexia of lower limbs (HP:0002600)	2.88338508
19	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.87284737
20	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.87284737
21	EMG: myopathic abnormalities (HP:0003458)	2.77797942
22	True hermaphroditism (HP:0010459)	2.69342088
23	Urinary urgency (HP:0000012)	2.64278239
24	Increased density of long bones (HP:0006392)	2.64065215
25	Aplasia/hypoplasia of the uterus (HP:0008684)	2.62167871
26	Pancreatic islet-cell hyperplasia (HP:0004510)	2.57756120
27	Sensory axonal neuropathy (HP:0003390)	2.57353016
28	Broad-based gait (HP:0002136)	2.55323640
29	Abnormality of lateral ventricle (HP:0030047)	2.54964834
30	Right ventricular cardiomyopathy (HP:0011663)	2.54958459
31	Rimmed vacuoles (HP:0003805)	2.52310121
32	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.47365420
33	Abnormal ciliary motility (HP:0012262)	2.45444569
34	Hypothermia (HP:0002045)	2.45007743
35	Intestinal atresia (HP:0011100)	2.44478858
36	Back pain (HP:0003418)	2.41163104
37	Protruding tongue (HP:0010808)	2.39302490
38	Pancreatic cysts (HP:0001737)	2.39200337
39	Abnormal protein glycosylation (HP:0012346)	2.38943920
40	Abnormal glycosylation (HP:0012345)	2.38943920
41	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.38943920
42	Abnormal protein N-linked glycosylation (HP:0012347)	2.38943920
43	Prolonged partial thromboplastin time (HP:0003645)	2.38309015
44	Sex reversal (HP:0012245)	2.37891173
45	Abnormal sex determination (HP:0012244)	2.37891173
46	Aplasia involving bones of the extremities (HP:0009825)	2.37073835
47	Aplasia involving bones of the upper limbs (HP:0009823)	2.37073835
48	Aplasia of the phalanges of the hand (HP:0009802)	2.37073835
49	Fetal akinesia sequence (HP:0001989)	2.35596222
50	Ketosis (HP:0001946)	2.26597760
51	Abnormality of endocrine pancreas physiology (HP:0012093)	2.24392397
52	Abnormality of the pancreatic islet cells (HP:0006476)	2.24392397
53	Bile duct proliferation (HP:0001408)	2.24289594
54	Abnormal biliary tract physiology (HP:0012439)	2.24289594
55	High anterior hairline (HP:0009890)	2.22871732
56	Abnormal rod and cone electroretinograms (HP:0008323)	2.21542679
57	Wrist flexion contracture (HP:0001239)	2.18635893
58	Muscular dystrophy (HP:0003560)	2.18259435
59	Unsteady gait (HP:0002317)	2.18201926
60	Eosinophilia (HP:0001880)	2.18069421
61	Hypoglycemic seizures (HP:0002173)	2.15994764
62	Abnormality of the intrinsic pathway (HP:0010989)	2.15598504
63	Molar tooth sign on MRI (HP:0002419)	2.13194434
64	Abnormality of midbrain morphology (HP:0002418)	2.13194434
65	Frequent falls (HP:0002359)	2.09839656
66	Occipital encephalocele (HP:0002085)	2.07630338
67	Male pseudohermaphroditism (HP:0000037)	2.06460949
68	Short tibia (HP:0005736)	2.04762914
69	Intellectual disability, progressive (HP:0006887)	2.03252451
70	Long clavicles (HP:0000890)	2.03178829
71	Abnormality of the metopic suture (HP:0005556)	2.02014441
72	Median cleft lip (HP:0000161)	1.99562874
73	Inability to walk (HP:0002540)	1.99560390
74	Abnormal respiratory motile cilium morphology (HP:0005938)	1.99070437
75	Abnormal respiratory epithelium morphology (HP:0012253)	1.99070437
76	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.99026846
77	Difficulty running (HP:0009046)	1.96359526
78	Delayed gross motor development (HP:0002194)	1.96038016
79	Prominent metopic ridge (HP:0005487)	1.95778464
80	Furrowed tongue (HP:0000221)	1.93208464
81	Exercise-induced myalgia (HP:0003738)	1.92986235
82	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.92545160
83	Cystic liver disease (HP:0006706)	1.91009390
84	Absent speech (HP:0001344)	1.90841221
85	Lipid accumulation in hepatocytes (HP:0006561)	1.90129659
86	Ventricular fibrillation (HP:0001663)	1.89973669
87	Bulbar palsy (HP:0001283)	1.89682583
88	Alacrima (HP:0000522)	1.86813707
89	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.85826460
90	Atonic seizures (HP:0010819)	1.85550748
91	Poor head control (HP:0002421)	1.85369743
92	Preaxial foot polydactyly (HP:0001841)	1.85193080
93	Hypomagnesemia (HP:0002917)	1.84309205
94	Abnormal respiratory motile cilium physiology (HP:0012261)	1.83644641
95	Abnormality of vitamin B metabolism (HP:0004340)	1.83594853
96	Hypoplastic ischia (HP:0003175)	1.82064763
97	Congenital sensorineural hearing impairment (HP:0008527)	1.80455308
98	Limb-girdle muscle atrophy (HP:0003797)	1.80257188
99	Increased circulating renin level (HP:0000848)	1.80257038
100	Myoglobinuria (HP:0002913)	1.77464604

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	7.33897347
2	OBSCN	3.36149130
3	ZAK	3.23197642
4	MARK3	3.17543521
5	LATS1	2.88708653
6	FRK	2.87811571
7	CASK	2.82008507
8	MAP4K2	2.72168181
9	TLK1	2.67409548
10	MYLK	2.50233964
11	STK38L	2.38947832
12	MAP2K7	2.36085085
13	VRK1	2.26945653
14	NEK2	1.94176702
15	TNIK	1.80149559
16	PRKG2	1.79183657
17	CSNK1G1	1.74476815
18	ARAF	1.73177875
19	PKN2	1.71128260
20	EIF2AK3	1.64129353
21	CSNK1G3	1.61024633
22	CSNK1A1L	1.60928903
23	DAPK3	1.54377633
24	CSNK1G2	1.40395730
25	TIE1	1.37012395
26	MOS	1.31842198
27	STK3	1.27949903
28	MAP3K4	1.21620374
29	MAP3K9	1.19162867
30	FGFR2	1.16408566
31	CDK3	1.15269934
32	BMPR1B	1.13216024
33	BCKDK	1.10214954
34	SGK223	1.09325596
35	SGK494	1.09325596
36	PHKG2	1.08458197
37	PHKG1	1.08458197
38	GRK1	1.07770128
39	RPS6KA5	1.06328712
40	FLT3	0.96607615
41	MAPK13	0.96467031
42	PAK3	0.94014573
43	DYRK2	0.89496226
44	SGK2	0.85588776
45	MST4	0.82567812
46	ADRBK2	0.79189276
47	LATS2	0.78657252
48	NLK	0.78656879
49	AKT2	0.77052084
50	MAPK12	0.72288188
51	NME2	0.71760577
52	PTK2B	0.69053333
53	PRKCQ	0.68120944
54	INSRR	0.64574744
55	NTRK3	0.64061632
56	DAPK2	0.59202889
57	AURKA	0.58852084
58	TNK2	0.57314214
59	STK38	0.56612367
60	CDK5	0.56444563
61	PAK1	0.56341529
62	MAP3K1	0.52497778
63	RPS6KB1	0.50351390
64	MAPKAPK3	0.50002207
65	ROCK1	0.49341766
66	DYRK3	0.48848705
67	NME1	0.48503748
68	AURKB	0.48180129
69	NEK1	0.46348227
70	WNK3	0.45575997
71	CSNK1A1	0.44184917
72	GRK5	0.43578851
73	PRKG1	0.40904993
74	STK4	0.40181241
75	PRKCE	0.38760808
76	TAF1	0.38515163
77	CAMK2D	0.35591029
78	TAOK1	0.35471691
79	TGFBR1	0.35469769
80	RET	0.33632264
81	PKN1	0.32544425
82	PLK3	0.31601815
83	BUB1	0.30619870
84	MAPKAPK5	0.30255640
85	STK16	0.30028550
86	PRKACB	0.28903964
87	FER	0.28825483
88	MELK	0.28460441
89	PRKCG	0.28329484
90	CDK14	0.27506213
91	EEF2K	0.27337722
92	MUSK	0.26948948
93	AKT3	0.26602030
94	CSNK1D	0.26414879
95	CAMK1	0.25644312
96	EGFR	0.25467186
97	RPS6KA4	0.22271021
98	PIK3CA	0.21767477
99	BRAF	0.20637230
100	ATM	0.19630538

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Systemic lupus erythematosus_Homo sapiens_hsa05322	4.39146676
2	Alcoholism_Homo sapiens_hsa05034	3.37845913
3	Butanoate metabolism_Homo sapiens_hsa00650	2.94256384
4	Folate biosynthesis_Homo sapiens_hsa00790	2.88577901
5	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.70216515
6	Circadian rhythm_Homo sapiens_hsa04710	2.42714571
7	Olfactory transduction_Homo sapiens_hsa04740	2.32891029
8	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.30481689
9	Nitrogen metabolism_Homo sapiens_hsa00910	1.99841603
10	Chemical carcinogenesis_Homo sapiens_hsa05204	1.94380150
11	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.87372831
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.79570105
13	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.66483260
14	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.64449422
15	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.60375065
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.57885277
17	Basal transcription factors_Homo sapiens_hsa03022	1.51076554
18	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.49133666
19	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.48407454
20	Selenocompound metabolism_Homo sapiens_hsa00450	1.46472913
21	RNA degradation_Homo sapiens_hsa03018	1.44040276
22	Arginine biosynthesis_Homo sapiens_hsa00220	1.43046407
23	Propanoate metabolism_Homo sapiens_hsa00640	1.40088454
24	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.38904032
25	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.35377786
26	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.30501835
27	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.25701827
28	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.25568515
29	Parkinsons disease_Homo sapiens_hsa05012	1.23349503
30	beta-Alanine metabolism_Homo sapiens_hsa00410	1.22873381
31	One carbon pool by folate_Homo sapiens_hsa00670	1.22659427
32	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.22659317
33	Purine metabolism_Homo sapiens_hsa00230	1.21424466
34	Sphingolipid metabolism_Homo sapiens_hsa00600	1.21105165
35	Mineral absorption_Homo sapiens_hsa04978	1.18397665
36	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.18390347
37	Caffeine metabolism_Homo sapiens_hsa00232	1.12369822
38	Glutathione metabolism_Homo sapiens_hsa00480	1.12317996
39	Circadian entrainment_Homo sapiens_hsa04713	1.11927240
40	Phototransduction_Homo sapiens_hsa04744	1.11410079
41	Oxidative phosphorylation_Homo sapiens_hsa00190	1.09441129
42	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.02660090
43	Insulin secretion_Homo sapiens_hsa04911	1.02467280
44	Taste transduction_Homo sapiens_hsa04742	1.02212791
45	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.02191883
46	Gastric acid secretion_Homo sapiens_hsa04971	1.01840084
47	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.01532821
48	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.00291253
49	Peroxisome_Homo sapiens_hsa04146	0.99330242
50	Salivary secretion_Homo sapiens_hsa04970	0.97700027
51	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.90133527
52	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.89639339
53	GABAergic synapse_Homo sapiens_hsa04727	0.87397007
54	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.86289535
55	Regulation of autophagy_Homo sapiens_hsa04140	0.85169199
56	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.84564956
57	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.82256916
58	Renin secretion_Homo sapiens_hsa04924	0.81214782
59	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.80867684
60	Retinol metabolism_Homo sapiens_hsa00830	0.80231680
61	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.78632493
62	Phenylalanine metabolism_Homo sapiens_hsa00360	0.73958481
63	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.72199190
64	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.70787361
65	Calcium signaling pathway_Homo sapiens_hsa04020	0.70394901
66	Protein export_Homo sapiens_hsa03060	0.66517544
67	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.64139784
68	Metabolic pathways_Homo sapiens_hsa01100	0.63602535
69	Glucagon signaling pathway_Homo sapiens_hsa04922	0.62812040
70	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.62600994
71	Tryptophan metabolism_Homo sapiens_hsa00380	0.59703719
72	Alzheimers disease_Homo sapiens_hsa05010	0.58486710
73	Tyrosine metabolism_Homo sapiens_hsa00350	0.55985282
74	Amphetamine addiction_Homo sapiens_hsa05031	0.53309640
75	Collecting duct acid secretion_Homo sapiens_hsa04966	0.52589678
76	Nucleotide excision repair_Homo sapiens_hsa03420	0.52461711
77	Gap junction_Homo sapiens_hsa04540	0.51509830
78	Cardiac muscle contraction_Homo sapiens_hsa04260	0.51373139
79	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.50716901
80	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.49475586
81	Nicotine addiction_Homo sapiens_hsa05033	0.48420370
82	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.46591777
83	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.46127027
84	Linoleic acid metabolism_Homo sapiens_hsa00591	0.46045566
85	Glutamatergic synapse_Homo sapiens_hsa04724	0.45369184
86	Type I diabetes mellitus_Homo sapiens_hsa04940	0.43865062
87	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.42650306
88	Type II diabetes mellitus_Homo sapiens_hsa04930	0.42068475
89	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.39154633
90	Fatty acid degradation_Homo sapiens_hsa00071	0.38943027
91	Cocaine addiction_Homo sapiens_hsa05030	0.38742812
92	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.38107960
93	Basal cell carcinoma_Homo sapiens_hsa05217	0.37959802
94	Sulfur relay system_Homo sapiens_hsa04122	0.37080325
95	Dopaminergic synapse_Homo sapiens_hsa04728	0.36592560
96	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.36406336
97	Oocyte meiosis_Homo sapiens_hsa04114	0.35638243
98	ABC transporters_Homo sapiens_hsa02010	0.35403418
99	Arginine and proline metabolism_Homo sapiens_hsa00330	0.34185088
100	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.31878542

BMS1P21

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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