ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA double-strand break processing (GO:0000729)	5.22023044
2	DNA deamination (GO:0045006)	4.03951083
3	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.88055656
4	rRNA catabolic process (GO:0016075)	3.87622036
5	replication fork processing (GO:0031297)	3.85210887
6	rRNA methylation (GO:0031167)	3.61405568
7	ubiquinone biosynthetic process (GO:0006744)	3.50796145
8	rRNA modification (GO:0000154)	3.49231800
9	centriole replication (GO:0007099)	3.49033999
10	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.45916344
11	ribosome assembly (GO:0042255)	3.44051829
12	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	3.40585388
13	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.38272526
14	DNA integration (GO:0015074)	3.38063729
15	neural tube formation (GO:0001841)	3.33550047
16	ubiquinone metabolic process (GO:0006743)	3.32890197
17	DNA catabolic process, exonucleolytic (GO:0000738)	3.32229834
18	DNA ligation (GO:0006266)	3.29823765
19	L-fucose catabolic process (GO:0042355)	3.25431522
20	fucose catabolic process (GO:0019317)	3.25431522
21	L-fucose metabolic process (GO:0042354)	3.25431522
22	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.22393104
23	pseudouridine synthesis (GO:0001522)	3.18582592
24	regulation of acyl-CoA biosynthetic process (GO:0050812)	3.18533563
25	double-strand break repair via homologous recombination (GO:0000724)	3.15557061
26	recombinational repair (GO:0000725)	3.14496703
27	centriole assembly (GO:0098534)	3.12388679
28	amino acid salvage (GO:0043102)	3.08083430
29	L-methionine salvage (GO:0071267)	3.08083430
30	L-methionine biosynthetic process (GO:0071265)	3.08083430
31	single strand break repair (GO:0000012)	3.04687897
32	response to pheromone (GO:0019236)	3.03522946
33	respiratory chain complex IV assembly (GO:0008535)	3.02822664
34	cellular ketone body metabolic process (GO:0046950)	3.02530710
35	methionine biosynthetic process (GO:0009086)	2.95871774
36	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.95626533
37	cell wall macromolecule catabolic process (GO:0016998)	2.93503789
38	cytochrome complex assembly (GO:0017004)	2.93179465
39	protein prenylation (GO:0018342)	2.93044628
40	prenylation (GO:0097354)	2.93044628
41	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.91480178
42	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.91480178
43	tryptophan metabolic process (GO:0006568)	2.90096388
44	regulation of telomere maintenance (GO:0032204)	2.89657644
45	ketone body metabolic process (GO:1902224)	2.89614944
46	indole-containing compound catabolic process (GO:0042436)	2.84826279
47	indolalkylamine catabolic process (GO:0046218)	2.84826279
48	tryptophan catabolic process (GO:0006569)	2.84826279
49	quinone biosynthetic process (GO:1901663)	2.83382403
50	ncRNA catabolic process (GO:0034661)	2.82989804
51	protein complex biogenesis (GO:0070271)	2.81012456
52	synapsis (GO:0007129)	2.80810767
53	male meiosis (GO:0007140)	2.80233881
54	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.80174308
55	resolution of meiotic recombination intermediates (GO:0000712)	2.79195872
56	axoneme assembly (GO:0035082)	2.75966507
57	indolalkylamine metabolic process (GO:0006586)	2.74139316
58	histone H2A acetylation (GO:0043968)	2.72630558
59	regulation of cofactor metabolic process (GO:0051193)	2.72578875
60	regulation of coenzyme metabolic process (GO:0051196)	2.72578875
61	kinetochore assembly (GO:0051382)	2.70492031
62	iron-sulfur cluster assembly (GO:0016226)	2.70086185
63	metallo-sulfur cluster assembly (GO:0031163)	2.70086185
64	reciprocal meiotic recombination (GO:0007131)	2.67980841
65	reciprocal DNA recombination (GO:0035825)	2.67980841
66	peptidyl-histidine modification (GO:0018202)	2.67906120
67	preassembly of GPI anchor in ER membrane (GO:0016254)	2.67168333
68	sperm motility (GO:0030317)	2.65562749
69	mitochondrial respiratory chain complex assembly (GO:0033108)	2.65502593
70	regulation of centriole replication (GO:0046599)	2.65342888
71	acrosome reaction (GO:0007340)	2.62063899
72	spermatid nucleus differentiation (GO:0007289)	2.61125284
73	regulation of mitotic spindle checkpoint (GO:1903504)	2.60040213
74	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.60040213
75	cell wall macromolecule metabolic process (GO:0044036)	2.59633673
76	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.59587950
77	NADH dehydrogenase complex assembly (GO:0010257)	2.59587950
78	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.59587950
79	telomere maintenance via semi-conservative replication (GO:0032201)	2.59189352
80	DNA methylation involved in gamete generation (GO:0043046)	2.58367402
81	proteasome assembly (GO:0043248)	2.57978484
82	histone exchange (GO:0043486)	2.54323267
83	DNA recombination (GO:0006310)	2.54161978
84	epithelial cilium movement (GO:0003351)	2.52146558
85	methionine metabolic process (GO:0006555)	2.51734960
86	regulation of sulfur metabolic process (GO:0042762)	2.51461465
87	maturation of 5.8S rRNA (GO:0000460)	2.50269960
88	DNA demethylation (GO:0080111)	2.49941650
89	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.48505690
90	regulation of translation, ncRNA-mediated (GO:0045974)	2.48505690
91	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.48505690
92	kinetochore organization (GO:0051383)	2.46465248
93	RNA phosphodiester bond hydrolysis (GO:0090501)	2.45741443
94	chromatin remodeling at centromere (GO:0031055)	2.45332201
95	tRNA modification (GO:0006400)	2.45070088
96	establishment of protein localization to Golgi (GO:0072600)	2.44544785
97	piRNA metabolic process (GO:0034587)	2.42987199
98	multicellular organism reproduction (GO:0032504)	2.42981562
99	histone H3-K9 methylation (GO:0051567)	2.42616450
100	telomere maintenance via recombination (GO:0000722)	2.41650805

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.93594654
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.79455654
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.66694093
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.49422425
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.46061416
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.34458280
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.18748376
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.86919176
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.71118801
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.69962388
11	VDR_22108803_ChIP-Seq_LS180_Human	2.68316773
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.43203086
13	ELK1_19687146_ChIP-ChIP_HELA_Human	2.34190977
14	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.33014941
15	E2F7_22180533_ChIP-Seq_HELA_Human	2.28903375
16	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.22066657
17	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.15798157
18	FUS_26573619_Chip-Seq_HEK293_Human	2.14214220
19	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.11621106
20	EWS_26573619_Chip-Seq_HEK293_Human	2.11240549
21	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.00850262
22	FOXP3_21729870_ChIP-Seq_TREG_Human	1.92639950
23	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.87554456
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.82884638
25	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.81681256
26	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.77779903
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.77469114
28	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.74663361
29	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.69574936
30	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.67414171
31	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.67336588
32	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.66681980
33	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.60191354
34	IRF1_19129219_ChIP-ChIP_H3396_Human	1.58051001
35	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.53832898
36	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.51376238
37	P300_19829295_ChIP-Seq_ESCs_Human	1.47599230
38	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.47508618
39	* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.45575280
40	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.44053280
41	CIITA_25753668_ChIP-Seq_RAJI_Human	1.43377882
42	TAF15_26573619_Chip-Seq_HEK293_Human	1.41374476
43	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.40029187
44	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.39496852
45	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.36209705
46	GBX2_23144817_ChIP-Seq_PC3_Human	1.34878077
47	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.34730640
48	CBP_20019798_ChIP-Seq_JUKART_Human	1.34730640
49	GABP_19822575_ChIP-Seq_HepG2_Human	1.34705314
50	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.34701847
51	TP53_22573176_ChIP-Seq_HFKS_Human	1.27788428
52	DCP1A_22483619_ChIP-Seq_HELA_Human	1.27489928
53	KDM5A_27292631_Chip-Seq_BREAST_Human	1.23734680
54	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.23237434
55	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.19099995
56	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.19092966
57	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.17069452
58	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.17043771
59	GATA3_26560356_Chip-Seq_TH2_Human	1.11168802
60	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.11012423
61	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.10957629
62	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.09826682
63	* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.08195317
64	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.07750409
65	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.07556937
66	SOX2_19829295_ChIP-Seq_ESCs_Human	1.06783072
67	NANOG_19829295_ChIP-Seq_ESCs_Human	1.06783072
68	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04558917
69	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.03617758
70	HOXB7_26014856_ChIP-Seq_BT474_Human	0.97681541
71	NCOR_22424771_ChIP-Seq_293T_Human	0.97081317
72	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.95451999
73	STAT3_23295773_ChIP-Seq_U87_Human	0.94536835
74	* FOXA1_25329375_ChIP-Seq_VCAP_Human	0.94222442
75	* FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.94222442
76	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.93943803
77	TCF4_22108803_ChIP-Seq_LS180_Human	0.93479301
78	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.93105136
79	AR_20517297_ChIP-Seq_VCAP_Human	0.92316555
80	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.91004922
81	AR_21572438_ChIP-Seq_LNCaP_Human	0.90978611
82	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.90733981
83	SMAD4_21799915_ChIP-Seq_A2780_Human	0.90649132
84	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.89885142
85	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.89751465
86	* FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.89725499
87	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.89590898
88	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.88341647
89	PHF8_20622853_ChIP-Seq_HELA_Human	0.88311566
90	* GATA3_21878914_ChIP-Seq_MCF-7_Human	0.88158146
91	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.88015772
92	MYB_26560356_Chip-Seq_TH2_Human	0.86595947
93	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.86590831
94	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.86256236
95	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.86256236
96	TCF4_23295773_ChIP-Seq_U87_Human	0.85996365
97	CDX2_22108803_ChIP-Seq_LS180_Human	0.85172748
98	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.84467746
99	RBPJ_21746931_ChIP-Seq_IB4_Human	0.84308128
100	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.84226836

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008058_abnormal_DNA_repair	3.87415757
2	MP0009697_abnormal_copulation	3.15336012
3	MP0002102_abnormal_ear_morphology	2.99404525
4	MP0010094_abnormal_chromosome_stability	2.99120569
5	MP0003806_abnormal_nucleotide_metabolis	2.74380705
6	MP0008877_abnormal_DNA_methylation	2.71280634
7	MP0000372_irregular_coat_pigmentation	2.55772191
8	MP0005410_abnormal_fertilization	2.42322482
9	MP0008995_early_reproductive_senescence	2.26362731
10	MP0003786_premature_aging	2.21263096
11	MP0003693_abnormal_embryo_hatching	2.21227203
12	MP0006072_abnormal_retinal_apoptosis	2.06952478
13	MP0008057_abnormal_DNA_replication	1.99908469
14	MP0005075_abnormal_melanosome_morpholog	1.99664432
15	MP0003718_maternal_effect	1.98823641
16	MP0001984_abnormal_olfaction	1.92658598
17	MP0006036_abnormal_mitochondrial_physio	1.92479233
18	MP0002160_abnormal_reproductive_system	1.89436010
19	MP0003646_muscle_fatigue	1.87532292
20	MP0001529_abnormal_vocalization	1.82547585
21	MP0003195_calcinosis	1.81340883
22	MP0001929_abnormal_gametogenesis	1.78959329
23	MP0003787_abnormal_imprinting	1.77125757
24	MP0005646_abnormal_pituitary_gland	1.76852345
25	MP0005253_abnormal_eye_physiology	1.70977751
26	MP0003136_yellow_coat_color	1.68517997
27	MP0006035_abnormal_mitochondrial_morpho	1.68338750
28	MP0001764_abnormal_homeostasis	1.64313302
29	MP0003698_abnormal_male_reproductive	1.61273223
30	MP0002132_abnormal_respiratory_system	1.57145085
31	MP0003111_abnormal_nucleus_morphology	1.56121559
32	MP0002837_dystrophic_cardiac_calcinosis	1.51934600
33	MP0008789_abnormal_olfactory_epithelium	1.50055544
34	MP0005394_taste/olfaction_phenotype	1.47647815
35	MP0005499_abnormal_olfactory_system	1.47647815
36	MP0005551_abnormal_eye_electrophysiolog	1.46956221
37	MP0008007_abnormal_cellular_replicative	1.44898026
38	MP0003077_abnormal_cell_cycle	1.42354082
39	MP0005389_reproductive_system_phenotype	1.36550839
40	MP0006292_abnormal_olfactory_placode	1.31593804
41	MP0001145_abnormal_male_reproductive	1.24543262
42	MP0002210_abnormal_sex_determination	1.21859522
43	MP0005645_abnormal_hypothalamus_physiol	1.18046656
44	MP0000653_abnormal_sex_gland	1.16094007
45	MP0001661_extended_life_span	1.12088960
46	MP0003567_abnormal_fetal_cardiomyocyte	1.10802903
47	MP0005174_abnormal_tail_pigmentation	1.10547427
48	MP0002095_abnormal_skin_pigmentation	1.07352389
49	MP0003121_genomic_imprinting	1.06627290
50	MP0008872_abnormal_physiological_respon	1.06565172
51	MP0000427_abnormal_hair_cycle	1.03011577
52	MP0003315_abnormal_perineum_morphology	1.02951715
53	MP0006276_abnormal_autonomic_nervous	1.01994356
54	MP0002751_abnormal_autonomic_nervous	0.99466683
55	MP0000516_abnormal_urinary_system	0.98422958
56	MP0005367_renal/urinary_system_phenotyp	0.98422958
57	MP0004957_abnormal_blastocyst_morpholog	0.97803717
58	MP0000015_abnormal_ear_pigmentation	0.97756652
59	MP0000465_gastrointestinal_hemorrhage	0.97567028
60	MP0001986_abnormal_taste_sensitivity	0.96965260
61	MP0002876_abnormal_thyroid_physiology	0.95637302
62	MP0004381_abnormal_hair_follicle	0.94429626
63	MP0004142_abnormal_muscle_tone	0.94202148
64	MP0001919_abnormal_reproductive_system	0.92878023
65	MP0004484_altered_response_of	0.91342372
66	MP0003763_abnormal_thymus_physiology	0.89278822
67	MP0001545_abnormal_hematopoietic_system	0.87197284
68	MP0005397_hematopoietic_system_phenotyp	0.87197284
69	MP0000631_abnormal_neuroendocrine_gland	0.86593530
70	MP0001905_abnormal_dopamine_level	0.85224006
71	MP0008775_abnormal_heart_ventricle	0.84323557
72	MP0001968_abnormal_touch/_nociception	0.83999576
73	MP0001188_hyperpigmentation	0.83551373
74	MP0004147_increased_porphyrin_level	0.83167287
75	MP0005187_abnormal_penis_morphology	0.83148997
76	MP0008932_abnormal_embryonic_tissue	0.83039663
77	MP0000647_abnormal_sebaceous_gland	0.78578418
78	MP0005647_abnormal_sex_gland	0.77231515
79	MP0002161_abnormal_fertility/fecundity	0.77141817
80	MP0001835_abnormal_antigen_presentation	0.76349368
81	MP0003172_abnormal_lysosome_physiology	0.75848335
82	MP0005220_abnormal_exocrine_pancreas	0.74031411
83	MP0005391_vision/eye_phenotype	0.73187614
84	MP0005266_abnormal_metabolism	0.72276072
85	MP0000383_abnormal_hair_follicle	0.71911637
86	MP0008875_abnormal_xenobiotic_pharmacok	0.70808106
87	MP0002019_abnormal_tumor_incidence	0.70796931
88	MP0002938_white_spotting	0.70011777
89	MP0004215_abnormal_myocardial_fiber	0.69924135
90	MP0002638_abnormal_pupillary_reflex	0.69411473
91	MP0002090_abnormal_vision	0.68965455
92	MP0001119_abnormal_female_reproductive	0.68720591
93	MP0000689_abnormal_spleen_morphology	0.68634164
94	MP0000569_abnormal_digit_pigmentation	0.65925429
95	MP0002127_abnormal_cardiovascular_syste	0.65878703
96	MP0002693_abnormal_pancreas_physiology	0.65493214
97	MP0003186_abnormal_redox_activity	0.65164591
98	MP0000703_abnormal_thymus_morphology	0.64992244
99	MP0010386_abnormal_urinary_bladder	0.61894889
100	MP0004742_abnormal_vestibular_system	0.61596629

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.45440959
2	True hermaphroditism (HP:0010459)	3.28477123
3	Pancreatic fibrosis (HP:0100732)	3.03595156
4	Chronic hepatic failure (HP:0100626)	2.93256370
5	Cerebellar dysplasia (HP:0007033)	2.77693413
6	Molar tooth sign on MRI (HP:0002419)	2.77068319
7	Abnormality of midbrain morphology (HP:0002418)	2.77068319
8	Lipid accumulation in hepatocytes (HP:0006561)	2.66826154
9	Abnormal biliary tract physiology (HP:0012439)	2.66598385
10	Bile duct proliferation (HP:0001408)	2.66598385
11	3-Methylglutaconic aciduria (HP:0003535)	2.65842464
12	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.56457153
13	Abnormality of the ileum (HP:0001549)	2.54892458
14	Hyperglycinemia (HP:0002154)	2.54875658
15	Abnormality of chromosome stability (HP:0003220)	2.50880663
16	Type II lissencephaly (HP:0007260)	2.50681215
17	Nephronophthisis (HP:0000090)	2.47082235
18	Increased CSF lactate (HP:0002490)	2.44020140
19	Meckel diverticulum (HP:0002245)	2.43551432
20	Hypothermia (HP:0002045)	2.42966533
21	Medial flaring of the eyebrow (HP:0010747)	2.42023873
22	Acute necrotizing encephalopathy (HP:0006965)	2.41301071
23	Attenuation of retinal blood vessels (HP:0007843)	2.38511493
24	Sloping forehead (HP:0000340)	2.37602982
25	Mitochondrial inheritance (HP:0001427)	2.36457728
26	Chromsome breakage (HP:0040012)	2.34651239
27	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.32080425
28	Abnormal protein N-linked glycosylation (HP:0012347)	2.32080425
29	Abnormal protein glycosylation (HP:0012346)	2.32080425
30	Abnormal glycosylation (HP:0012345)	2.32080425
31	Methylmalonic acidemia (HP:0002912)	2.30452000
32	Ketosis (HP:0001946)	2.29766543
33	Clubbing of toes (HP:0100760)	2.28887974
34	Hepatocellular necrosis (HP:0001404)	2.27969487
35	Thyroiditis (HP:0100646)	2.27208172
36	Progressive macrocephaly (HP:0004481)	2.24667296
37	Congenital stationary night blindness (HP:0007642)	2.24316178
38	Acute encephalopathy (HP:0006846)	2.24060448
39	Reduced antithrombin III activity (HP:0001976)	2.22854650
40	Abnormal mitochondria in muscle tissue (HP:0008316)	2.22056297
41	Tubulointerstitial nephritis (HP:0001970)	2.15516154
42	Intestinal atresia (HP:0011100)	2.12774035
43	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.12378477
44	Abnormal rod and cone electroretinograms (HP:0008323)	2.11049038
45	Increased serum lactate (HP:0002151)	2.09925323
46	Male pseudohermaphroditism (HP:0000037)	2.09039008
47	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.08987704
48	Abnormality of the preputium (HP:0100587)	2.08178619
49	Abnormality of the renal medulla (HP:0100957)	2.07327489
50	Abnormality of DNA repair (HP:0003254)	2.06289803
51	Abnormality of the labia minora (HP:0012880)	2.04097646
52	Increased hepatocellular lipid droplets (HP:0006565)	2.03406802
53	Abolished electroretinogram (ERG) (HP:0000550)	2.02892880
54	Abnormality of the renal cortex (HP:0011035)	2.01919815
55	Absent thumb (HP:0009777)	2.01758888
56	Hepatic necrosis (HP:0002605)	2.01663363
57	Severe combined immunodeficiency (HP:0004430)	2.00245625
58	Pancreatic islet-cell hyperplasia (HP:0004510)	2.00142981
59	Abnormality of the columella (HP:0009929)	1.98635552
60	Pendular nystagmus (HP:0012043)	1.98463695
61	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.97456900
62	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.97456900
63	Renal cortical cysts (HP:0000803)	1.96850156
64	Abnormality of endocrine pancreas physiology (HP:0012093)	1.95759308
65	Abnormality of the pancreatic islet cells (HP:0006476)	1.95759308
66	Cystic liver disease (HP:0006706)	1.95042137
67	Duodenal stenosis (HP:0100867)	1.90847389
68	Small intestinal stenosis (HP:0012848)	1.90847389
69	Methylmalonic aciduria (HP:0012120)	1.88824320
70	Eosinophilia (HP:0001880)	1.87985742
71	Inability to walk (HP:0002540)	1.86791639
72	Panhypogammaglobulinemia (HP:0003139)	1.86436725
73	Abnormality of the renal collecting system (HP:0004742)	1.85744053
74	Aplasia/hypoplasia of the uterus (HP:0008684)	1.85331528
75	Ketoacidosis (HP:0001993)	1.84976350
76	Optic disc pallor (HP:0000543)	1.84729637
77	Median cleft lip (HP:0000161)	1.84697644
78	Anencephaly (HP:0002323)	1.83781188
79	Volvulus (HP:0002580)	1.83664029
80	Unsteady gait (HP:0002317)	1.83072593
81	Duplicated collecting system (HP:0000081)	1.82031696
82	Lactic acidosis (HP:0003128)	1.80072547
83	Neoplasm of the adrenal cortex (HP:0100641)	1.78931891
84	Sclerocornea (HP:0000647)	1.78711615
85	Abnormality of lateral ventricle (HP:0030047)	1.78167031
86	Abnormality of eosinophils (HP:0001879)	1.75993805
87	Lethargy (HP:0001254)	1.73019305
88	Abnormality of glycine metabolism (HP:0010895)	1.72362203
89	Abnormality of serine family amino acid metabolism (HP:0010894)	1.72362203
90	Hypoglycemic seizures (HP:0002173)	1.72209119
91	Aplastic anemia (HP:0001915)	1.71753318
92	Thyroid-stimulating hormone excess (HP:0002925)	1.71116437
93	Hypoplasia of the uterus (HP:0000013)	1.70954984
94	Abnormality of the pons (HP:0007361)	1.70931354
95	Progressive inability to walk (HP:0002505)	1.70096075
96	Abnormality of the duodenum (HP:0002246)	1.69897536
97	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.69629637
98	Abnormality of alanine metabolism (HP:0010916)	1.69629637
99	Hyperalaninemia (HP:0003348)	1.69629637
100	Astigmatism (HP:0000483)	1.69162300

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.25290906
2	PINK1	4.02518693
3	MAP4K2	3.87559020
4	WNK3	2.79117413
5	EIF2AK3	2.77429769
6	ZAK	2.61554646
7	MARK3	2.61272270
8	TAOK3	2.22742574
9	PLK4	2.15162294
10	BMPR1B	2.09997864
11	MAP2K7	2.01048558
12	NUAK1	2.00350791
13	BCKDK	1.85576317
14	MAP3K4	1.77659468
15	TXK	1.75512184
16	TLK1	1.65930771
17	SRPK1	1.64288250
18	BRSK2	1.53135959
19	TRIM28	1.50419466
20	NEK2	1.46059770
21	BUB1	1.44674443
22	CSNK1G3	1.40569936
23	CSNK1A1L	1.35672831
24	MST4	1.35526490
25	VRK1	1.34971345
26	CSNK1G1	1.30331829
27	MAPK13	1.29863331
28	CDC7	1.29036455
29	ADRBK2	1.28776690
30	CSNK1G2	1.25448113
31	OBSCN	1.24622090
32	STK16	1.22082503
33	PBK	1.22005768
34	TEC	1.18507671
35	RPS6KA4	1.17003212
36	ERBB3	1.16699085
37	GRK1	1.13626879
38	PLK3	1.10439021
39	DYRK3	1.09874954
40	OXSR1	1.08037188
41	MKNK1	1.06622406
42	PLK2	1.05408854
43	INSRR	1.05341528
44	MKNK2	1.04886478
45	STK39	1.02138199
46	PLK1	0.98774059
47	CDK3	0.95991911
48	ATR	0.94889709
49	CCNB1	0.93108319
50	RPS6KA5	0.87802235
51	BRD4	0.86432888
52	NME1	0.83994360
53	STK38L	0.83683853
54	ATM	0.82252634
55	WEE1	0.79925264
56	ITK	0.79849101
57	WNK4	0.76688445
58	MAPKAPK3	0.76178536
59	FLT3	0.75520762
60	BTK	0.70750482
61	FGFR2	0.69946176
62	TNIK	0.69583074
63	PRKCQ	0.68600350
64	MAP3K5	0.67850508
65	NLK	0.64273367
66	PDK2	0.63346525
67	MAPKAPK5	0.62965272
68	BCR	0.59578535
69	STK4	0.59459505
70	TTK	0.57055486
71	PIK3CA	0.55506464
72	BMPR2	0.54307487
73	LATS1	0.54091861
74	DYRK2	0.52209742
75	AURKB	0.49491890
76	ACVR1B	0.45870030
77	EIF2AK1	0.43690414
78	CHEK2	0.42995173
79	CHEK1	0.42166371
80	EIF2AK2	0.40024256
81	IKBKB	0.40000098
82	VRK2	0.39344668
83	IRAK1	0.38639556
84	TGFBR1	0.37596326
85	PIM1	0.37112226
86	CSNK1A1	0.34815504
87	CSNK1D	0.34431115
88	PAK3	0.31963487
89	PIK3CG	0.31876840
90	CSNK2A1	0.30630236
91	CASK	0.30336156
92	CSNK2A2	0.30267037
93	TIE1	0.30136762
94	PRKCE	0.29455102
95	SYK	0.28735851
96	CDK1	0.28414508
97	STK3	0.27360820
98	RPS6KB1	0.25953378
99	MAP4K1	0.25620685
100	PRKAA2	0.24023090

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Homologous recombination_Homo sapiens_hsa03440	3.13884103
2	Fanconi anemia pathway_Homo sapiens_hsa03460	3.08591677
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.06741720
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.90108338
5	Butanoate metabolism_Homo sapiens_hsa00650	2.70453983
6	DNA replication_Homo sapiens_hsa03030	2.60492864
7	Non-homologous end-joining_Homo sapiens_hsa03450	2.52043948
8	RNA polymerase_Homo sapiens_hsa03020	2.51964034
9	Mismatch repair_Homo sapiens_hsa03430	2.44880610
10	Basal transcription factors_Homo sapiens_hsa03022	2.33085165
11	RNA degradation_Homo sapiens_hsa03018	2.30452222
12	Propanoate metabolism_Homo sapiens_hsa00640	2.28581824
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.07571599
14	Proteasome_Homo sapiens_hsa03050	2.07253596
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.98740532
16	Protein export_Homo sapiens_hsa03060	1.85697443
17	Nucleotide excision repair_Homo sapiens_hsa03420	1.85453439
18	Base excision repair_Homo sapiens_hsa03410	1.83742901
19	One carbon pool by folate_Homo sapiens_hsa00670	1.83072941
20	Olfactory transduction_Homo sapiens_hsa04740	1.81638647
21	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.80874380
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.79904745
23	RNA transport_Homo sapiens_hsa03013	1.70708920
24	Spliceosome_Homo sapiens_hsa03040	1.68337879
25	Pyrimidine metabolism_Homo sapiens_hsa00240	1.65433086
26	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.63049035
27	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.56733721
28	Phototransduction_Homo sapiens_hsa04744	1.55960280
29	Nitrogen metabolism_Homo sapiens_hsa00910	1.50813978
30	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.50752465
31	Purine metabolism_Homo sapiens_hsa00230	1.46151655
32	Selenocompound metabolism_Homo sapiens_hsa00450	1.43312230
33	Regulation of autophagy_Homo sapiens_hsa04140	1.37932836
34	Oxidative phosphorylation_Homo sapiens_hsa00190	1.36438889
35	Primary immunodeficiency_Homo sapiens_hsa05340	1.34309781
36	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.30689306
37	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.28488176
38	Peroxisome_Homo sapiens_hsa04146	1.22668373
39	Parkinsons disease_Homo sapiens_hsa05012	1.17136846
40	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.13983411
41	Tryptophan metabolism_Homo sapiens_hsa00380	1.12167421
42	Fatty acid elongation_Homo sapiens_hsa00062	1.02958866
43	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.01220556
44	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.98823689
45	Fatty acid metabolism_Homo sapiens_hsa01212	0.90894897
46	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.90413950
47	Chemical carcinogenesis_Homo sapiens_hsa05204	0.83627682
48	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.82931268
49	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.81845754
50	Oocyte meiosis_Homo sapiens_hsa04114	0.77730965
51	Cell cycle_Homo sapiens_hsa04110	0.77143474
52	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.74845496
53	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.74685361
54	Huntingtons disease_Homo sapiens_hsa05016	0.73881565
55	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.72695300
56	Metabolic pathways_Homo sapiens_hsa01100	0.72467137
57	Circadian rhythm_Homo sapiens_hsa04710	0.71495595
58	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.70164715
59	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.69693376
60	Glutathione metabolism_Homo sapiens_hsa00480	0.67517992
61	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.67134839
62	Taste transduction_Homo sapiens_hsa04742	0.67056524
63	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.65831879
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.65576480
65	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.65385322
66	mRNA surveillance pathway_Homo sapiens_hsa03015	0.64341593
67	Fatty acid degradation_Homo sapiens_hsa00071	0.64340537
68	Lysine degradation_Homo sapiens_hsa00310	0.62873451
69	Steroid biosynthesis_Homo sapiens_hsa00100	0.62333012
70	Linoleic acid metabolism_Homo sapiens_hsa00591	0.61614744
71	Pyruvate metabolism_Homo sapiens_hsa00620	0.61461354
72	p53 signaling pathway_Homo sapiens_hsa04115	0.56768502
73	Ether lipid metabolism_Homo sapiens_hsa00565	0.56471536
74	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.55651582
75	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.55022679
76	beta-Alanine metabolism_Homo sapiens_hsa00410	0.54667621
77	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.53396116
78	Alzheimers disease_Homo sapiens_hsa05010	0.50321806
79	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.47728438
80	Type I diabetes mellitus_Homo sapiens_hsa04940	0.46235774
81	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.45712294
82	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.43052466
83	Caffeine metabolism_Homo sapiens_hsa00232	0.43024336
84	Retinol metabolism_Homo sapiens_hsa00830	0.42881518
85	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.40406690
86	Alcoholism_Homo sapiens_hsa05034	0.40280628
87	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.40223217
88	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.40149451
89	Asthma_Homo sapiens_hsa05310	0.35460272
90	ABC transporters_Homo sapiens_hsa02010	0.33810586
91	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.31043643
92	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.29272675
93	Herpes simplex infection_Homo sapiens_hsa05168	0.27702691
94	Sulfur relay system_Homo sapiens_hsa04122	0.27649478
95	Sulfur metabolism_Homo sapiens_hsa00920	0.25910410
96	Graft-versus-host disease_Homo sapiens_hsa05332	0.24379005
97	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.22189454
98	Allograft rejection_Homo sapiens_hsa05330	0.20647327
99	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.20384293
100	Salivary secretion_Homo sapiens_hsa04970	0.20006103

BMS1P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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