ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	water-soluble vitamin biosynthetic process (GO:0042364)	4.47660868
2	kynurenine metabolic process (GO:0070189)	4.39773550
3	DNA deamination (GO:0045006)	4.32195347
4	indole-containing compound catabolic process (GO:0042436)	4.31676693
5	indolalkylamine catabolic process (GO:0046218)	4.31676693
6	tryptophan catabolic process (GO:0006569)	4.31676693
7	maturation of 5.8S rRNA (GO:0000460)	3.91318812
8	respiratory chain complex IV assembly (GO:0008535)	3.74552253
9	cullin deneddylation (GO:0010388)	3.69370764
10	response to pheromone (GO:0019236)	3.69145111
11	protein complex biogenesis (GO:0070271)	3.66044638
12	protein deneddylation (GO:0000338)	3.65638459
13	protein-cofactor linkage (GO:0018065)	3.63979646
14	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.59458285
15	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.56943255
16	amine catabolic process (GO:0009310)	3.52792439
17	cellular biogenic amine catabolic process (GO:0042402)	3.52792439
18	regulation of hexokinase activity (GO:1903299)	3.52055754
19	regulation of glucokinase activity (GO:0033131)	3.52055754
20	preassembly of GPI anchor in ER membrane (GO:0016254)	3.49530080
21	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.48085783
22	axoneme assembly (GO:0035082)	3.47204973
23	tryptophan metabolic process (GO:0006568)	3.43767549
24	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.43560431
25	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.39953762
26	NADH dehydrogenase complex assembly (GO:0010257)	3.39953762
27	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.39953762
28	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.39649718
29	cytochrome complex assembly (GO:0017004)	3.32494459
30	mitochondrial respiratory chain complex assembly (GO:0033108)	3.30762433
31	regulation of cilium movement (GO:0003352)	3.30699680
32	chaperone-mediated protein transport (GO:0072321)	3.29873807
33	fucose catabolic process (GO:0019317)	3.29871502
34	L-fucose metabolic process (GO:0042354)	3.29871502
35	L-fucose catabolic process (GO:0042355)	3.29871502
36	epithelial cilium movement (GO:0003351)	3.29390470
37	indolalkylamine metabolic process (GO:0006586)	3.26531549
38	kidney morphogenesis (GO:0060993)	3.24177579
39	protein neddylation (GO:0045116)	3.23926935
40	protein polyglutamylation (GO:0018095)	3.23051361
41	piRNA metabolic process (GO:0034587)	3.12555321
42	ATP synthesis coupled proton transport (GO:0015986)	3.06305173
43	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.06305173
44	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	2.97148943
45	pseudouridine synthesis (GO:0001522)	2.96378332
46	synapsis (GO:0007129)	2.94531477
47	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.93384335
48	cilium morphogenesis (GO:0060271)	2.92497314
49	detection of light stimulus involved in visual perception (GO:0050908)	2.91070549
50	detection of light stimulus involved in sensory perception (GO:0050962)	2.91070549
51	aromatic amino acid family catabolic process (GO:0009074)	2.90450040
52	replication fork processing (GO:0031297)	2.90230598
53	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.86660645
54	termination of RNA polymerase III transcription (GO:0006386)	2.86660645
55	resolution of meiotic recombination intermediates (GO:0000712)	2.86228665
56	microtubule severing (GO:0051013)	2.84119006
57	nonmotile primary cilium assembly (GO:0035058)	2.84035927
58	inositol phosphate dephosphorylation (GO:0046855)	2.77556686
59	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.77556686
60	DNA double-strand break processing (GO:0000729)	2.75661492
61	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.75539322
62	platelet dense granule organization (GO:0060155)	2.73014900
63	gamma-aminobutyric acid transport (GO:0015812)	2.71109320
64	regulation of microtubule-based movement (GO:0060632)	2.70791223
65	brain morphogenesis (GO:0048854)	2.70542471
66	recombinational repair (GO:0000725)	2.68269027
67	adenosine metabolic process (GO:0046085)	2.66703995
68	response to nitrosative stress (GO:0051409)	2.66259350
69	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.65517032
70	inositol phosphate catabolic process (GO:0071545)	2.64875372
71	cilium organization (GO:0044782)	2.64670491
72	cilium movement (GO:0003341)	2.63885547
73	ubiquinone biosynthetic process (GO:0006744)	2.62259659
74	rRNA modification (GO:0000154)	2.62154786
75	protein prenylation (GO:0018342)	2.61315645
76	prenylation (GO:0097354)	2.61315645
77	GPI anchor metabolic process (GO:0006505)	2.60600880
78	proteasome assembly (GO:0043248)	2.60022135
79	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.59669050
80	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.58766528
81	double-strand break repair via homologous recombination (GO:0000724)	2.56887158
82	protein K6-linked ubiquitination (GO:0085020)	2.56576209
83	cilium assembly (GO:0042384)	2.56313524
84	dopamine transport (GO:0015872)	2.56101468
85	benzene-containing compound metabolic process (GO:0042537)	2.54487907
86	mannosylation (GO:0097502)	2.54197349
87	behavioral response to nicotine (GO:0035095)	2.53830093
88	electron transport chain (GO:0022900)	2.52965368
89	transcription from mitochondrial promoter (GO:0006390)	2.52608182
90	respiratory electron transport chain (GO:0022904)	2.50981560
91	oxidative demethylation (GO:0070989)	2.50952838
92	aldehyde catabolic process (GO:0046185)	2.50841652
93	tRNA processing (GO:0008033)	2.50237205
94	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.49092251
95	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.49092251
96	isotype switching (GO:0045190)	2.49092251
97	ubiquinone metabolic process (GO:0006743)	2.47690693
98	neuronal action potential propagation (GO:0019227)	2.47126356
99	indole-containing compound metabolic process (GO:0042430)	2.45727936
100	L-methionine biosynthetic process (GO:0071265)	2.43890083

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.54893028
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.27322343
3	VDR_22108803_ChIP-Seq_LS180_Human	3.23177179
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.22089274
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.00164700
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.81146685
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.55651100
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.35919416
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.33813470
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.24336866
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.16710531
12	EZH2_22144423_ChIP-Seq_EOC_Human	2.12519220
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.07556544
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.05855251
15	EWS_26573619_Chip-Seq_HEK293_Human	2.01917316
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.00780392
17	TP53_22573176_ChIP-Seq_HFKS_Human	1.95673755
18	ELK1_19687146_ChIP-ChIP_HELA_Human	1.91286706
19	IRF1_19129219_ChIP-ChIP_H3396_Human	1.88835450
20	TAF15_26573619_Chip-Seq_HEK293_Human	1.87601606
21	MYC_18940864_ChIP-ChIP_HL60_Human	1.84418930
22	VDR_23849224_ChIP-Seq_CD4+_Human	1.79774875
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.76256417
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.74669097
25	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.73332833
26	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.73211311
27	FUS_26573619_Chip-Seq_HEK293_Human	1.71215217
28	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.69326627
29	FOXP3_21729870_ChIP-Seq_TREG_Human	1.65731869
30	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.65382696
31	P300_19829295_ChIP-Seq_ESCs_Human	1.62021080
32	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.61599056
33	CBP_20019798_ChIP-Seq_JUKART_Human	1.56810874
34	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.56810874
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.54891191
36	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.54514726
37	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.52567174
38	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.52307208
39	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.48764532
40	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.46876477
41	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.43667436
42	ER_23166858_ChIP-Seq_MCF-7_Human	1.43047884
43	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.40760394
44	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.40655841
45	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.39733327
46	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.36945793
47	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.35769040
48	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.34768221
49	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.34285668
50	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.32984367
51	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.32661445
52	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.32617444
53	GABP_19822575_ChIP-Seq_HepG2_Human	1.31728953
54	NCOR_22424771_ChIP-Seq_293T_Human	1.30313820
55	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.25865711
56	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.25612309
57	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.25076387
58	BCAT_22108803_ChIP-Seq_LS180_Human	1.23539637
59	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.23481600
60	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.23097435
61	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.20681235
62	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.19996270
63	NANOG_19829295_ChIP-Seq_ESCs_Human	1.17386181
64	SOX2_19829295_ChIP-Seq_ESCs_Human	1.17386181
65	HOXB7_26014856_ChIP-Seq_BT474_Human	1.14070613
66	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.14056835
67	TCF4_22108803_ChIP-Seq_LS180_Human	1.13805580
68	AR_20517297_ChIP-Seq_VCAP_Human	1.13749626
69	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.12675510
70	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.12675510
71	AR_25329375_ChIP-Seq_VCAP_Human	1.11047333
72	RNF2_27304074_Chip-Seq_NSC_Mouse	1.10805233
73	CDX2_22108803_ChIP-Seq_LS180_Human	1.10254077
74	TCF4_23295773_ChIP-Seq_U87_Human	1.08994164
75	STAT3_23295773_ChIP-Seq_U87_Human	1.06984893
76	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.06371738
77	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.06003543
78	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.05776754
79	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.05035636
80	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.05012339
81	HTT_18923047_ChIP-ChIP_STHdh_Human	1.04911399
82	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.04761411
83	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.04371974
84	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.04357584
85	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.03591202
86	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.01804403
87	SMAD4_21799915_ChIP-Seq_A2780_Human	1.01351687
88	RUNX2_22187159_ChIP-Seq_PCA_Human	1.00828097
89	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.99603722
90	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.97415282
91	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.97389010
92	TTF2_22483619_ChIP-Seq_HELA_Human	0.96843083
93	REST_21632747_ChIP-Seq_MESCs_Mouse	0.96669365
94	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.96606402
95	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.96395504
96	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.92584729
97	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.92120401
98	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.91313682
99	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.90796409
100	MYC_19829295_ChIP-Seq_ESCs_Human	0.90739414

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.23603857
2	MP0008877_abnormal_DNA_methylation	3.22270300
3	MP0008875_abnormal_xenobiotic_pharmacok	2.92501210
4	MP0006292_abnormal_olfactory_placode	2.76732716
5	MP0001984_abnormal_olfaction	2.60283335
6	MP0008789_abnormal_olfactory_epithelium	2.44958201
7	MP0002102_abnormal_ear_morphology	2.42621310
8	MP0004142_abnormal_muscle_tone	2.36700652
9	MP0003122_maternal_imprinting	2.33329526
10	MP0001529_abnormal_vocalization	2.15946709
11	MP0003787_abnormal_imprinting	2.13179229
12	MP0002837_dystrophic_cardiac_calcinosis	2.08814289
13	MP0005551_abnormal_eye_electrophysiolog	2.04508987
14	MP0005394_taste/olfaction_phenotype	1.97644079
15	MP0005499_abnormal_olfactory_system	1.97644079
16	MP0000427_abnormal_hair_cycle	1.92428007
17	MP0002938_white_spotting	1.91925508
18	MP0009046_muscle_twitch	1.90230688
19	MP0003121_genomic_imprinting	1.84971936
20	MP0004133_heterotaxia	1.84842315
21	MP0006072_abnormal_retinal_apoptosis	1.83677654
22	MP0005379_endocrine/exocrine_gland_phen	1.78549797
23	MP0002653_abnormal_ependyma_morphology	1.73739247
24	MP0006276_abnormal_autonomic_nervous	1.71651109
25	MP0008872_abnormal_physiological_respon	1.66942553
26	MP0008058_abnormal_DNA_repair	1.63162230
27	MP0004147_increased_porphyrin_level	1.62868018
28	MP0005646_abnormal_pituitary_gland	1.61184268
29	MP0003195_calcinosis	1.57145314
30	MP0002160_abnormal_reproductive_system	1.52629680
31	MP0003011_delayed_dark_adaptation	1.51940048
32	MP0002163_abnormal_gland_morphology	1.50563488
33	MP0005389_reproductive_system_phenotype	1.49630007
34	MP0005360_urolithiasis	1.49094153
35	MP0002876_abnormal_thyroid_physiology	1.46614232
36	MP0002638_abnormal_pupillary_reflex	1.45577875
37	MP0001986_abnormal_taste_sensitivity	1.45238682
38	MP0002138_abnormal_hepatobiliary_system	1.41149436
39	MP0002272_abnormal_nervous_system	1.40976525
40	MP0004145_abnormal_muscle_electrophysio	1.37510523
41	MP0009745_abnormal_behavioral_response	1.35076508
42	MP0002557_abnormal_social/conspecific_i	1.34341999
43	MP0003186_abnormal_redox_activity	1.31943898
44	MP0000372_irregular_coat_pigmentation	1.28535271
45	MP0000631_abnormal_neuroendocrine_gland	1.27087194
46	MP0001485_abnormal_pinna_reflex	1.25337200
47	MP0003718_maternal_effect	1.24298545
48	MP0001486_abnormal_startle_reflex	1.23641083
49	MP0001968_abnormal_touch/_nociception	1.21783522
50	MP0005253_abnormal_eye_physiology	1.20593953
51	MP0002736_abnormal_nociception_after	1.19931793
52	MP0005645_abnormal_hypothalamus_physiol	1.18475609
53	MP0001905_abnormal_dopamine_level	1.17093086
54	MP0005174_abnormal_tail_pigmentation	1.12610415
55	MP0002572_abnormal_emotion/affect_behav	1.11099749
56	MP0010329_abnormal_lipoprotein_level	1.09282723
57	MP0002733_abnormal_thermal_nociception	1.08417791
58	MP0000013_abnormal_adipose_tissue	1.08416325
59	MP0004885_abnormal_endolymph	1.07337502
60	MP0001764_abnormal_homeostasis	1.07068631
61	MP0001293_anophthalmia	1.06598181
62	MP0000358_abnormal_cell_content/	1.06339898
63	MP0008775_abnormal_heart_ventricle	1.06048543
64	MP0006054_spinal_hemorrhage	1.05254040
65	MP0003646_muscle_fatigue	1.03756993
66	MP0002184_abnormal_innervation	1.03712883
67	MP0002210_abnormal_sex_determination	1.03384082
68	MP0002928_abnormal_bile_duct	1.03302242
69	MP0005332_abnormal_amino_acid	0.99782295
70	MP0001929_abnormal_gametogenesis	0.98491122
71	MP0001970_abnormal_pain_threshold	0.97336790
72	MP0000647_abnormal_sebaceous_gland	0.97135038
73	MP0004043_abnormal_pH_regulation	0.97049000
74	MP0009697_abnormal_copulation	0.95363845
75	MP0001919_abnormal_reproductive_system	0.94658728
76	MP0005085_abnormal_gallbladder_physiolo	0.93804893
77	MP0009780_abnormal_chondrocyte_physiolo	0.93698787
78	MP0005377_hearing/vestibular/ear_phenot	0.92875765
79	MP0003878_abnormal_ear_physiology	0.92875765
80	MP0000778_abnormal_nervous_system	0.90162190
81	MP0005636_abnormal_mineral_homeostasis	0.88392282
82	MP0002734_abnormal_mechanical_nocicepti	0.87135784
83	MP0001501_abnormal_sleep_pattern	0.84846745
84	MP0001324_abnormal_eye_pigmentation	0.84598413
85	MP0005195_abnormal_posterior_eye	0.82609068
86	MP0005220_abnormal_exocrine_pancreas	0.82571317
87	MP0000653_abnormal_sex_gland	0.82530908
88	MP0008995_early_reproductive_senescence	0.82365234
89	MP0002095_abnormal_skin_pigmentation	0.81909174
90	MP0002234_abnormal_pharynx_morphology	0.81650719
91	MP0002063_abnormal_learning/memory/cond	0.80363011
92	MP0002752_abnormal_somatic_nervous	0.80134241
93	MP0006036_abnormal_mitochondrial_physio	0.80092747
94	MP0005386_behavior/neurological_phenoty	0.79230899
95	MP0004924_abnormal_behavior	0.79230899
96	MP0004215_abnormal_myocardial_fiber	0.79180852
97	MP0005410_abnormal_fertilization	0.77873445
98	MP0003137_abnormal_impulse_conducting	0.77828151
99	MP0006035_abnormal_mitochondrial_morpho	0.77474445
100	MP0003937_abnormal_limbs/digits/tail_de	0.77266812

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic fibrosis (HP:0100732)	5.11782960
2	True hermaphroditism (HP:0010459)	4.91397869
3	Pancreatic cysts (HP:0001737)	4.55141766
4	Acute necrotizing encephalopathy (HP:0006965)	3.82437748
5	Molar tooth sign on MRI (HP:0002419)	3.63937035
6	Abnormality of midbrain morphology (HP:0002418)	3.63937035
7	Nephronophthisis (HP:0000090)	3.58215991
8	Medial flaring of the eyebrow (HP:0010747)	3.49771988
9	Progressive macrocephaly (HP:0004481)	3.36170704
10	Acute encephalopathy (HP:0006846)	3.35121934
11	Abnormal mitochondria in muscle tissue (HP:0008316)	3.31900560
12	Methylmalonic acidemia (HP:0002912)	3.29616830
13	Increased CSF lactate (HP:0002490)	3.12535175
14	Cystic liver disease (HP:0006706)	3.06370938
15	Mitochondrial inheritance (HP:0001427)	2.98612729
16	Abnormality of the renal medulla (HP:0100957)	2.91866045
17	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.91437690
18	Sclerocornea (HP:0000647)	2.88294468
19	Gait imbalance (HP:0002141)	2.79979465
20	Congenital primary aphakia (HP:0007707)	2.75406114
21	Abnormality of the labia minora (HP:0012880)	2.69550841
22	Renal cortical cysts (HP:0000803)	2.63794013
23	Chronic hepatic failure (HP:0100626)	2.60269581
24	Abnormality of the renal cortex (HP:0011035)	2.58664972
25	Postaxial foot polydactyly (HP:0001830)	2.57947752
26	Nephrogenic diabetes insipidus (HP:0009806)	2.55940301
27	Male pseudohermaphroditism (HP:0000037)	2.52573052
28	Concave nail (HP:0001598)	2.50614817
29	Anencephaly (HP:0002323)	2.48859279
30	Hepatic necrosis (HP:0002605)	2.46960101
31	Methylmalonic aciduria (HP:0012120)	2.43758433
32	Hepatocellular necrosis (HP:0001404)	2.42293244
33	Congenital hepatic fibrosis (HP:0002612)	2.42124004
34	Occipital encephalocele (HP:0002085)	2.41246035
35	Increased serum lactate (HP:0002151)	2.41151751
36	Cerebral edema (HP:0002181)	2.37567089
37	Optic disc pallor (HP:0000543)	2.37216882
38	Supernumerary spleens (HP:0009799)	2.36150535
39	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.32471991
40	Abnormality of alanine metabolism (HP:0010916)	2.32471991
41	Hyperalaninemia (HP:0003348)	2.32471991
42	Asplenia (HP:0001746)	2.28919556
43	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.24064002
44	Polyphagia (HP:0002591)	2.23162867
45	Abnormality of vitamin B metabolism (HP:0004340)	2.15787320
46	Abnormal hair whorl (HP:0010721)	2.13826539
47	Hyperglycinuria (HP:0003108)	2.13752049
48	Severe muscular hypotonia (HP:0006829)	2.11406182
49	Hypomagnesemia (HP:0002917)	2.11001303
50	Progressive cerebellar ataxia (HP:0002073)	2.09631188
51	Abnormal respiratory epithelium morphology (HP:0012253)	2.07978278
52	Abnormal respiratory motile cilium morphology (HP:0005938)	2.07978278
53	Poor suck (HP:0002033)	2.06960497
54	Furrowed tongue (HP:0000221)	2.06359408
55	Type 2 muscle fiber atrophy (HP:0003554)	2.06357248
56	Congenital stationary night blindness (HP:0007642)	2.06031878
57	Abnormal biliary tract physiology (HP:0012439)	2.05756492
58	Bile duct proliferation (HP:0001408)	2.05756492
59	Abolished electroretinogram (ERG) (HP:0000550)	2.03998980
60	Postaxial hand polydactyly (HP:0001162)	2.02845933
61	Genital tract atresia (HP:0001827)	2.02575456
62	Vaginal atresia (HP:0000148)	2.02328301
63	Abnormal ciliary motility (HP:0012262)	2.00534712
64	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.98215585
65	Hypoplasia of the fovea (HP:0007750)	1.98215585
66	Preaxial hand polydactyly (HP:0001177)	1.95191181
67	Hypoplasia of the uterus (HP:0000013)	1.95113271
68	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.94553286
69	Hypoplasia of the pons (HP:0012110)	1.94494713
70	Type II lissencephaly (HP:0007260)	1.94232317
71	Aplasia/hypoplasia of the uterus (HP:0008684)	1.93807433
72	Optic nerve hypoplasia (HP:0000609)	1.90280952
73	Lactic acidosis (HP:0003128)	1.89504603
74	Narrow forehead (HP:0000341)	1.88781142
75	Hyperglycinemia (HP:0002154)	1.87437975
76	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.86980873
77	Hypothermia (HP:0002045)	1.85113803
78	Tubular atrophy (HP:0000092)	1.84916880
79	Abnormality of the pons (HP:0007361)	1.83568815
80	Attenuation of retinal blood vessels (HP:0007843)	1.82639396
81	Progressive microcephaly (HP:0000253)	1.79492721
82	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.79481278
83	Increased corneal curvature (HP:0100692)	1.79429719
84	Keratoconus (HP:0000563)	1.79429719
85	Poor coordination (HP:0002370)	1.78054638
86	Increased hepatocellular lipid droplets (HP:0006565)	1.77362965
87	Abnormal rod and cone electroretinograms (HP:0008323)	1.76931628
88	Lethargy (HP:0001254)	1.74971657
89	Oculomotor apraxia (HP:0000657)	1.73956601
90	Pendular nystagmus (HP:0012043)	1.73520997
91	Abnormality of serum amino acid levels (HP:0003112)	1.73058718
92	Mesangial abnormality (HP:0001966)	1.72909329
93	Abnormality of serine family amino acid metabolism (HP:0010894)	1.72434386
94	Abnormality of glycine metabolism (HP:0010895)	1.72434386
95	Large for gestational age (HP:0001520)	1.72272555
96	Intestinal atresia (HP:0011100)	1.71867274
97	Dandy-Walker malformation (HP:0001305)	1.70443213
98	Lipid accumulation in hepatocytes (HP:0006561)	1.70046702
99	Pachygyria (HP:0001302)	1.66674761
100	Delayed CNS myelination (HP:0002188)	1.66037899

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.16577300
2	FRK	3.48241600
3	PINK1	2.99037584
4	BMPR1B	2.93897731
5	MST4	2.92836298
6	WNK4	2.35087444
7	WNK3	2.34936011
8	ZAK	2.30586547
9	NUAK1	2.12601566
10	ADRBK2	1.96629007
11	TRIM28	1.93690066
12	MKNK2	1.84219115
13	GRK1	1.83435200
14	TLK1	1.82396336
15	PHKG1	1.76099599
16	PHKG2	1.76099599
17	PLK2	1.63305624
18	CASK	1.63260174
19	CDK8	1.59347384
20	DYRK2	1.53467513
21	BCR	1.47741932
22	TNIK	1.46115158
23	BCKDK	1.43365988
24	STK39	1.41470985
25	NEK1	1.37395637
26	TXK	1.33512071
27	MAP3K4	1.31576341
28	PNCK	1.25836737
29	MKNK1	1.23118786
30	EIF2AK3	1.18489287
31	TAOK3	1.17715398
32	BUB1	1.13376719
33	CDK19	1.12461674
34	TSSK6	1.11430208
35	PLK3	1.10158185
36	TGFBR1	1.07008904
37	MAPK13	1.06535746
38	OXSR1	1.06220560
39	PLK4	1.00150088
40	SRPK1	0.98981337
41	MAP2K7	0.98725562
42	PDK2	0.95411367
43	PAK3	0.92624645
44	FER	0.91934105
45	PRKCG	0.89925787
46	INSRR	0.89177426
47	CSNK1G3	0.87202240
48	PLK1	0.84901478
49	CSNK1G2	0.83649612
50	MARK1	0.83225450
51	PRKCE	0.82188187
52	CSNK1G1	0.81782132
53	PRKCI	0.77819318
54	EIF2AK1	0.74575186
55	CSNK1A1L	0.71227183
56	STK16	0.71098269
57	NME1	0.70360842
58	FGFR2	0.68492358
59	STK3	0.68369649
60	TIE1	0.66643982
61	MAP3K9	0.63764592
62	ACVR1B	0.61293792
63	STK38L	0.60778856
64	DYRK3	0.59619344
65	ADRBK1	0.57939345
66	ERBB3	0.57526864
67	MAP2K6	0.56350076
68	OBSCN	0.55837081
69	LIMK1	0.53199703
70	ATR	0.52628012
71	VRK2	0.52214515
72	CAMK2A	0.51305162
73	PASK	0.51121511
74	MAP3K12	0.50355533
75	NEK2	0.50333277
76	PRKCQ	0.48097797
77	FLT3	0.48090295
78	PBK	0.47884612
79	VRK1	0.47668401
80	KIT	0.47578919
81	PRKACB	0.44878833
82	PRKACA	0.44100278
83	DAPK2	0.43300424
84	ATM	0.42973932
85	CAMK2D	0.42155570
86	CSNK1E	0.41705498
87	RPS6KA4	0.41300341
88	CSNK2A1	0.39766567
89	AURKB	0.39480845
90	PIK3CA	0.38247135
91	BRSK2	0.36941166
92	RPS6KA5	0.36845318
93	PRKCA	0.36635678
94	CSNK2A2	0.35113101
95	ERBB4	0.34986111
96	CSNK1A1	0.34028622
97	TTK	0.33953048
98	ARAF	0.31116807
99	PRKAA1	0.30651350
100	AURKA	0.30201459

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	4.39980795
2	Protein export_Homo sapiens_hsa03060	3.50516135
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.78066318
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.53784414
5	RNA polymerase_Homo sapiens_hsa03020	2.53154922
6	Parkinsons disease_Homo sapiens_hsa05012	2.29203827
7	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.21064221
8	Steroid biosynthesis_Homo sapiens_hsa00100	2.07419012
9	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.07171469
10	Basal transcription factors_Homo sapiens_hsa03022	2.07129609
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.04877480
12	Selenocompound metabolism_Homo sapiens_hsa00450	1.94800058
13	Proteasome_Homo sapiens_hsa03050	1.94777350
14	RNA degradation_Homo sapiens_hsa03018	1.85168682
15	Propanoate metabolism_Homo sapiens_hsa00640	1.81494962
16	Phototransduction_Homo sapiens_hsa04744	1.81477239
17	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.73718141
18	Butanoate metabolism_Homo sapiens_hsa00650	1.73124648
19	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.71841905
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.68501674
21	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.57383687
22	Huntingtons disease_Homo sapiens_hsa05016	1.55934274
23	Homologous recombination_Homo sapiens_hsa03440	1.55504631
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.54241709
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.48986874
26	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.48398754
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.39125935
28	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.37932358
29	Alzheimers disease_Homo sapiens_hsa05010	1.37465432
30	Mismatch repair_Homo sapiens_hsa03430	1.33168802
31	Folate biosynthesis_Homo sapiens_hsa00790	1.21366606
32	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.21360339
33	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.19818605
34	Asthma_Homo sapiens_hsa05310	1.18675576
35	Peroxisome_Homo sapiens_hsa04146	1.18369330
36	Ether lipid metabolism_Homo sapiens_hsa00565	1.16005420
37	Ribosome_Homo sapiens_hsa03010	1.13214797
38	Cardiac muscle contraction_Homo sapiens_hsa04260	1.12764876
39	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.09263419
40	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.08331447
41	Base excision repair_Homo sapiens_hsa03410	1.07520448
42	Pyrimidine metabolism_Homo sapiens_hsa00240	1.05832474
43	One carbon pool by folate_Homo sapiens_hsa00670	1.04320472
44	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.02163431
45	Olfactory transduction_Homo sapiens_hsa04740	1.01518487
46	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.00502179
47	Nicotine addiction_Homo sapiens_hsa05033	1.00189178
48	RNA transport_Homo sapiens_hsa03013	0.97707221
49	Regulation of autophagy_Homo sapiens_hsa04140	0.97461683
50	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.97141963
51	Purine metabolism_Homo sapiens_hsa00230	0.96717546
52	Nucleotide excision repair_Homo sapiens_hsa03420	0.95417235
53	Nitrogen metabolism_Homo sapiens_hsa00910	0.95302583
54	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.93413066
55	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.93143006
56	Non-homologous end-joining_Homo sapiens_hsa03450	0.92024767
57	Sulfur metabolism_Homo sapiens_hsa00920	0.90951836
58	Insulin secretion_Homo sapiens_hsa04911	0.89833389
59	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.88146788
60	Fatty acid elongation_Homo sapiens_hsa00062	0.87947537
61	Chemical carcinogenesis_Homo sapiens_hsa05204	0.86061748
62	Metabolic pathways_Homo sapiens_hsa01100	0.82583959
63	DNA replication_Homo sapiens_hsa03030	0.75434833
64	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.75387179
65	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.73804019
66	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.67838851
67	Retinol metabolism_Homo sapiens_hsa00830	0.67773485
68	Pyruvate metabolism_Homo sapiens_hsa00620	0.67008291
69	Type I diabetes mellitus_Homo sapiens_hsa04940	0.63128758
70	GABAergic synapse_Homo sapiens_hsa04727	0.59650872
71	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.59208437
72	ABC transporters_Homo sapiens_hsa02010	0.59200077
73	Oocyte meiosis_Homo sapiens_hsa04114	0.58448352
74	Morphine addiction_Homo sapiens_hsa05032	0.57732782
75	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.57209480
76	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.56314276
77	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.56126937
78	beta-Alanine metabolism_Homo sapiens_hsa00410	0.55548969
79	Taste transduction_Homo sapiens_hsa04742	0.52295288
80	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.52051426
81	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.51231242
82	Collecting duct acid secretion_Homo sapiens_hsa04966	0.50360590
83	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48782183
84	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.47281077
85	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.47041027
86	Glutathione metabolism_Homo sapiens_hsa00480	0.46325301
87	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.46052103
88	Sulfur relay system_Homo sapiens_hsa04122	0.43505489
89	Fat digestion and absorption_Homo sapiens_hsa04975	0.43134864
90	Lysine degradation_Homo sapiens_hsa00310	0.42915559
91	Serotonergic synapse_Homo sapiens_hsa04726	0.42695108
92	Arginine and proline metabolism_Homo sapiens_hsa00330	0.42686916
93	Fatty acid metabolism_Homo sapiens_hsa01212	0.41421405
94	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.39106665
95	Fatty acid degradation_Homo sapiens_hsa00071	0.37656734
96	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.33274568
97	Salivary secretion_Homo sapiens_hsa04970	0.32988067
98	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.32146208
99	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.30307906
100	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.29139861

BMS1P8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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