ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	water-soluble vitamin biosynthetic process (GO:0042364)	5.07685988
2	cellular ketone body metabolic process (GO:0046950)	4.18196031
3	response to pheromone (GO:0019236)	4.05050044
4	respiratory chain complex IV assembly (GO:0008535)	3.92542519
5	negative regulation of neurological system process (GO:0031645)	3.90979569
6	regulation of hexokinase activity (GO:1903299)	3.88655437
7	regulation of glucokinase activity (GO:0033131)	3.88655437
8	protein localization to cilium (GO:0061512)	3.86437581
9	ketone body metabolic process (GO:1902224)	3.68594626
10	inositol phosphate catabolic process (GO:0071545)	3.61267518
11	negative regulation of membrane potential (GO:0045837)	3.46199889
12	platelet dense granule organization (GO:0060155)	3.45797239
13	detection of calcium ion (GO:0005513)	3.41583119
14	pyrimidine nucleobase catabolic process (GO:0006208)	3.30016141
15	dendritic spine morphogenesis (GO:0060997)	3.28490836
16	lactate metabolic process (GO:0006089)	3.24420139
17	nucleobase catabolic process (GO:0046113)	3.23998655
18	cytochrome complex assembly (GO:0017004)	3.22799842
19	inositol phosphate dephosphorylation (GO:0046855)	3.22328621
20	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.22328621
21	brain morphogenesis (GO:0048854)	3.10170678
22	positive regulation of mitochondrial fission (GO:0090141)	3.02846937
23	cullin deneddylation (GO:0010388)	3.02845826
24	positive regulation of actin filament depolymerization (GO:0030836)	3.02348889
25	peptidyl-histidine modification (GO:0018202)	2.98184032
26	peroxisome fission (GO:0016559)	2.96664727
27	adult feeding behavior (GO:0008343)	2.90942974
28	nonmotile primary cilium assembly (GO:0035058)	2.89687877
29	negative regulation of telomere maintenance (GO:0032205)	2.88756685
30	cornea development in camera-type eye (GO:0061303)	2.86613445
31	peptidyl-cysteine modification (GO:0018198)	2.85309006
32	protein complex biogenesis (GO:0070271)	2.85242257
33	intraciliary transport (GO:0042073)	2.80752506
34	lipid particle organization (GO:0034389)	2.80521327
35	vascular smooth muscle contraction (GO:0014829)	2.80377802
36	protein deneddylation (GO:0000338)	2.79663007
37	response to lipoprotein particle (GO:0055094)	2.78449635
38	cilium morphogenesis (GO:0060271)	2.77016052
39	negative regulation of execution phase of apoptosis (GO:1900118)	2.73189011
40	xenobiotic catabolic process (GO:0042178)	2.72895289
41	protein-cofactor linkage (GO:0018065)	2.72379830
42	mannosylation (GO:0097502)	2.71369427
43	magnesium ion transport (GO:0015693)	2.70706728
44	polyol catabolic process (GO:0046174)	2.69974299
45	C-terminal protein lipidation (GO:0006501)	2.68538452
46	positive regulation of insulin secretion (GO:0032024)	2.68091964
47	glycosphingolipid biosynthetic process (GO:0006688)	2.67436938
48	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	2.67376235
49	melanosome transport (GO:0032402)	2.66664058
50	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.64625231
51	intra-Golgi vesicle-mediated transport (GO:0006891)	2.63359495
52	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	2.61602558
53	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.60965885
54	branched-chain amino acid catabolic process (GO:0009083)	2.60908680
55	aldehyde catabolic process (GO:0046185)	2.59934611
56	mitochondrial respiratory chain complex assembly (GO:0033108)	2.58547349
57	righting reflex (GO:0060013)	2.58293743
58	insulin secretion (GO:0030073)	2.57144418
59	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.56197617
60	C-terminal protein amino acid modification (GO:0018410)	2.55881772
61	signal peptide processing (GO:0006465)	2.55187851
62	establishment of melanosome localization (GO:0032401)	2.54306326
63	positive regulation of peptide hormone secretion (GO:0090277)	2.53699955
64	melanosome localization (GO:0032400)	2.52125955
65	regulation of transmission of nerve impulse (GO:0051969)	2.51759004
66	artery smooth muscle contraction (GO:0014824)	2.51415374
67	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	2.50396220
68	gamma-aminobutyric acid transport (GO:0015812)	2.49381601
69	presynaptic membrane assembly (GO:0097105)	2.48693583
70	pigment granule transport (GO:0051904)	2.48687526
71	coenzyme catabolic process (GO:0009109)	2.47692419
72	protein localization to Golgi apparatus (GO:0034067)	2.46960481
73	vitamin biosynthetic process (GO:0009110)	2.46886244
74	positive regulation of peptide secretion (GO:0002793)	2.46168288
75	retinal ganglion cell axon guidance (GO:0031290)	2.46051782
76	cilium assembly (GO:0042384)	2.44691821
77	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.44320003
78	cilium organization (GO:0044782)	2.43072196
79	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.42835044
80	parental behavior (GO:0060746)	2.42506331
81	GPI anchor metabolic process (GO:0006505)	2.41929200
82	regulation of type B pancreatic cell apoptotic process (GO:2000674)	2.41551488
83	somite rostral/caudal axis specification (GO:0032525)	2.39128427
84	positive regulation of glycolytic process (GO:0045821)	2.37908312
85	establishment of pigment granule localization (GO:0051905)	2.37648675
86	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.36999678
87	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.36999678
88	pigment granule localization (GO:0051875)	2.36888130
89	prostate gland growth (GO:0060736)	2.35431126
90	endocrine pancreas development (GO:0031018)	2.32927930
91	nitric oxide mediated signal transduction (GO:0007263)	2.30022728
92	zinc ion transport (GO:0006829)	2.30003778
93	terpenoid biosynthetic process (GO:0016114)	2.29631490
94	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.29086780
95	DNA double-strand break processing (GO:0000729)	2.28779344
96	regulation of acrosome reaction (GO:0060046)	2.28363093
97	succinate metabolic process (GO:0006105)	2.28068564
98	pyrimidine dimer repair (GO:0006290)	2.27361201
99	preassembly of GPI anchor in ER membrane (GO:0016254)	2.26675273
100	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.25451193

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.29217539
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.04705773
3	ZFP57_27257070_Chip-Seq_ESCs_Mouse	3.04329346
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.03025255
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.83356203
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.73834157
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.31143329
8	VDR_22108803_ChIP-Seq_LS180_Human	2.25368417
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.22407527
10	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.20675196
11	P300_19829295_ChIP-Seq_ESCs_Human	2.16402664
12	FUS_26573619_Chip-Seq_HEK293_Human	2.11701474
13	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.08447674
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.99767193
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.99454310
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.97484517
17	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.96205417
18	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.96046686
19	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.92679090
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.90784191
21	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.90722502
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.78324481
23	EWS_26573619_Chip-Seq_HEK293_Human	1.77144951
24	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.74881605
25	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.72340710
26	SMAD4_21799915_ChIP-Seq_A2780_Human	1.71109989
27	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.68081612
28	AR_25329375_ChIP-Seq_VCAP_Human	1.64756835
29	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.62963736
30	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.61664578
31	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.59407847
32	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.58879872
33	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.57123669
34	CBP_20019798_ChIP-Seq_JUKART_Human	1.57123669
35	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.56735974
36	BCAT_22108803_ChIP-Seq_LS180_Human	1.56686199
37	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.53698168
38	STAT3_23295773_ChIP-Seq_U87_Human	1.49581686
39	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.48019957
40	ER_23166858_ChIP-Seq_MCF-7_Human	1.47400946
41	TP53_22573176_ChIP-Seq_HFKS_Human	1.47018397
42	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.46286441
43	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.45694842
44	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.43731718
45	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.41966898
46	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.41783491
47	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.38885295
48	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.38741027
49	TP53_18474530_ChIP-ChIP_U2OS_Human	1.36712568
50	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.33610782
51	ELK1_19687146_ChIP-ChIP_HELA_Human	1.32000761
52	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.31828070
53	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.30128334
54	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.29634151
55	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.28445758
56	NANOG_19829295_ChIP-Seq_ESCs_Human	1.28207632
57	SOX2_19829295_ChIP-Seq_ESCs_Human	1.28207632
58	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.27893431
59	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.27603190
60	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.26927527
61	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.25933831
62	TCF4_23295773_ChIP-Seq_U87_Human	1.25152434
63	HTT_18923047_ChIP-ChIP_STHdh_Human	1.23144311
64	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.22961558
65	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.22716409
66	REST_21632747_ChIP-Seq_MESCs_Mouse	1.22546750
67	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.20772354
68	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.19153066
69	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.16811810
70	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.16644524
71	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.16387714
72	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.16387714
73	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.15037487
74	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.14185914
75	RUNX2_22187159_ChIP-Seq_PCA_Human	1.13333597
76	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.13152520
77	P53_22387025_ChIP-Seq_ESCs_Mouse	1.11981444
78	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.10209769
79	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.09760785
80	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.09735758
81	TCF4_22108803_ChIP-Seq_LS180_Human	1.09706657
82	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.07721254
83	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.07592715
84	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.07456082
85	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.05987961
86	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.04950688
87	CDX2_22108803_ChIP-Seq_LS180_Human	1.03330531
88	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.02418834
89	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.01188904
90	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.00761546
91	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.00730417
92	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.00219111
93	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.00098411
94	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.98729441
95	VDR_23849224_ChIP-Seq_CD4+_Human	0.98026227
96	RNF2_27304074_Chip-Seq_NSC_Mouse	0.97808351
97	NCOR_22424771_ChIP-Seq_293T_Human	0.97353759
98	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.95790974
99	JUN_21703547_ChIP-Seq_K562_Human	0.95168726
100	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.94148832

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002822_catalepsy	3.89854145
2	MP0003195_calcinosis	3.79744597
3	MP0002837_dystrophic_cardiac_calcinosis	3.39698974
4	MP0009780_abnormal_chondrocyte_physiolo	3.34980158
5	MP0003787_abnormal_imprinting	3.27465849
6	MP0008877_abnormal_DNA_methylation	3.21562786
7	MP0002254_reproductive_system_inflammat	2.86823085
8	MP0003122_maternal_imprinting	2.75878961
9	MP0002102_abnormal_ear_morphology	2.44885817
10	MP0000516_abnormal_urinary_system	2.39667424
11	MP0005367_renal/urinary_system_phenotyp	2.39667424
12	MP0001529_abnormal_vocalization	2.35685364
13	MP0005646_abnormal_pituitary_gland	2.30198495
14	MP0009046_muscle_twitch	2.22243628
15	MP0010234_abnormal_vibrissa_follicle	2.20714117
16	MP0005379_endocrine/exocrine_gland_phen	2.19700533
17	MP0002909_abnormal_adrenal_gland	2.14686691
18	MP0001984_abnormal_olfaction	2.11878805
19	MP0006072_abnormal_retinal_apoptosis	1.96341431
20	MP0003121_genomic_imprinting	1.94103706
21	MP0000569_abnormal_digit_pigmentation	1.90281991
22	MP0002163_abnormal_gland_morphology	1.82238801
23	MP0002638_abnormal_pupillary_reflex	1.79497139
24	MP0000013_abnormal_adipose_tissue	1.75401514
25	MP0003283_abnormal_digestive_organ	1.70522123
26	MP0004142_abnormal_muscle_tone	1.63622138
27	MP0005248_abnormal_Harderian_gland	1.55785811
28	MP0008789_abnormal_olfactory_epithelium	1.54052718
29	MP0005187_abnormal_penis_morphology	1.44189366
30	MP0005645_abnormal_hypothalamus_physiol	1.43636796
31	MP0004270_analgesia	1.35397838
32	MP0003880_abnormal_central_pattern	1.27977015
33	MP0005551_abnormal_eye_electrophysiolog	1.27113728
34	MP0002272_abnormal_nervous_system	1.23936576
35	MP0002938_white_spotting	1.23760965
36	MP0009745_abnormal_behavioral_response	1.22914866
37	MP0005253_abnormal_eye_physiology	1.20127750
38	MP0002139_abnormal_hepatobiliary_system	1.18305812
39	MP0004133_heterotaxia	1.17975210
40	MP0002734_abnormal_mechanical_nocicepti	1.17875703
41	MP0005499_abnormal_olfactory_system	1.17383639
42	MP0005394_taste/olfaction_phenotype	1.17383639
43	MP0001905_abnormal_dopamine_level	1.14474680
44	MP0010386_abnormal_urinary_bladder	1.14006590
45	MP0004147_increased_porphyrin_level	1.13654912
46	MP0005084_abnormal_gallbladder_morpholo	1.13562133
47	MP0008057_abnormal_DNA_replication	1.11925890
48	MP0005386_behavior/neurological_phenoty	1.09428510
49	MP0004924_abnormal_behavior	1.09428510
50	MP0004215_abnormal_myocardial_fiber	1.07114320
51	MP0002233_abnormal_nose_morphology	1.05303865
52	MP0005332_abnormal_amino_acid	1.04307460
53	MP0002090_abnormal_vision	1.04151227
54	MP0002557_abnormal_social/conspecific_i	1.02981517
55	MP0001944_abnormal_pancreas_morphology	1.00583408
56	MP0002064_seizures	0.98447786
57	MP0000427_abnormal_hair_cycle	0.96351702
58	MP0006036_abnormal_mitochondrial_physio	0.96329209
59	MP0000639_abnormal_adrenal_gland	0.94824267
60	MP0009697_abnormal_copulation	0.93433083
61	MP0010678_abnormal_skin_adnexa	0.93028864
62	MP0002572_abnormal_emotion/affect_behav	0.92890397
63	MP0000613_abnormal_salivary_gland	0.92702661
64	MP0008872_abnormal_physiological_respon	0.90852472
65	MP0006054_spinal_hemorrhage	0.90638752
66	MP0002876_abnormal_thyroid_physiology	0.89211032
67	MP0002693_abnormal_pancreas_physiology	0.88759011
68	MP0005266_abnormal_metabolism	0.85645859
69	MP0003011_delayed_dark_adaptation	0.85516421
70	MP0006035_abnormal_mitochondrial_morpho	0.85473016
71	MP0004043_abnormal_pH_regulation	0.83133545
72	MP0003635_abnormal_synaptic_transmissio	0.83122517
73	MP0001756_abnormal_urination	0.82503231
74	MP0001986_abnormal_taste_sensitivity	0.79579951
75	MP0001764_abnormal_homeostasis	0.79173499
76	MP0002160_abnormal_reproductive_system	0.78801722
77	MP0002332_abnormal_exercise_endurance	0.78718494
78	MP0008775_abnormal_heart_ventricle	0.78660146
79	MP0000647_abnormal_sebaceous_gland	0.78141674
80	MP0005085_abnormal_gallbladder_physiolo	0.77852388
81	MP0000631_abnormal_neuroendocrine_gland	0.77565332
82	MP0001270_distended_abdomen	0.77140198
83	MP0006292_abnormal_olfactory_placode	0.77012581
84	MP0006276_abnormal_autonomic_nervous	0.76820446
85	MP0001970_abnormal_pain_threshold	0.75681882
86	MP0000015_abnormal_ear_pigmentation	0.74304156
87	MP0001486_abnormal_startle_reflex	0.74243701
88	MP0000538_abnormal_urinary_bladder	0.73828591
89	MP0002069_abnormal_eating/drinking_beha	0.73075655
90	MP0010329_abnormal_lipoprotein_level	0.72395433
91	MP0002928_abnormal_bile_duct	0.71328973
92	MP0008058_abnormal_DNA_repair	0.70962257
93	MP0003937_abnormal_limbs/digits/tail_de	0.70766772
94	MP0000749_muscle_degeneration	0.70689920
95	MP0002277_abnormal_respiratory_mucosa	0.70345848
96	MP0004134_abnormal_chest_morphology	0.69773673
97	MP0003755_abnormal_palate_morphology	0.69356586
98	MP0004085_abnormal_heartbeat	0.68353840
99	MP0004019_abnormal_vitamin_homeostasis	0.68027174
100	MP0001968_abnormal_touch/_nociception	0.67714879

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Medial flaring of the eyebrow (HP:0010747)	3.77350033
2	Methylmalonic acidemia (HP:0002912)	3.43338054
3	Gait imbalance (HP:0002141)	3.36271486
4	Progressive macrocephaly (HP:0004481)	3.35885101
5	Pancreatic fibrosis (HP:0100732)	3.27330021
6	Congenital primary aphakia (HP:0007707)	3.24202927
7	Hypothermia (HP:0002045)	3.17946209
8	Acute necrotizing encephalopathy (HP:0006965)	3.11114015
9	Methylmalonic aciduria (HP:0012120)	3.10172821
10	Cutaneous melanoma (HP:0012056)	3.04244712
11	Neoplasm of the adrenal cortex (HP:0100641)	3.02572321
12	Pancreatic cysts (HP:0001737)	3.01441444
13	Urethral obstruction (HP:0000796)	2.95324819
14	True hermaphroditism (HP:0010459)	2.90781213
15	Hemiparesis (HP:0001269)	2.83933504
16	Nephrogenic diabetes insipidus (HP:0009806)	2.80514766
17	Abnormality of vitamin B metabolism (HP:0004340)	2.80416386
18	Hypoglycemic coma (HP:0001325)	2.78924476
19	Poor suck (HP:0002033)	2.76849739
20	Hyperinsulinemic hypoglycemia (HP:0000825)	2.76035433
21	Acute encephalopathy (HP:0006846)	2.74957279
22	Nephronophthisis (HP:0000090)	2.74702099
23	Abnormality of midbrain morphology (HP:0002418)	2.70368812
24	Molar tooth sign on MRI (HP:0002419)	2.70368812
25	Hypoglycemic seizures (HP:0002173)	2.70260741
26	Genital tract atresia (HP:0001827)	2.66913987
27	Abnormal mitochondria in muscle tissue (HP:0008316)	2.66168451
28	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.52582743
29	3-Methylglutaconic aciduria (HP:0003535)	2.52505805
30	Neonatal respiratory distress (HP:0002643)	2.51517821
31	Mitochondrial inheritance (HP:0001427)	2.45607927
32	Hematochezia (HP:0002573)	2.39677999
33	Large for gestational age (HP:0001520)	2.39647296
34	Neoplasm of the adrenal gland (HP:0100631)	2.37044113
35	Vaginal atresia (HP:0000148)	2.35822924
36	Delayed gross motor development (HP:0002194)	2.34756485
37	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	2.33195175
38	Hypomagnesemia (HP:0002917)	2.33032780
39	Hypsarrhythmia (HP:0002521)	2.32190464
40	EEG with generalized epileptiform discharges (HP:0011198)	2.31671444
41	Increased CSF lactate (HP:0002490)	2.28572848
42	Muscular hypotonia of the trunk (HP:0008936)	2.28489035
43	Hyperglycemia (HP:0003074)	2.25678547
44	Abnormality of the renal medulla (HP:0100957)	2.24947788
45	Ketoacidosis (HP:0001993)	2.24304274
46	Epileptiform EEG discharges (HP:0011182)	2.23257755
47	Amblyopia (HP:0000646)	2.16553570
48	Chronic hepatic failure (HP:0100626)	2.15084247
49	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.11863209
50	Poor coordination (HP:0002370)	2.11440028
51	Abnormality of the labia minora (HP:0012880)	2.10432483
52	Decreased muscle mass (HP:0003199)	2.09996641
53	Polyphagia (HP:0002591)	2.09400617
54	Polydipsia (HP:0001959)	2.05525897
55	Abnormal drinking behavior (HP:0030082)	2.05525897
56	Hepatic necrosis (HP:0002605)	2.05038850
57	Occipital encephalocele (HP:0002085)	2.04672771
58	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.03504686
59	Furrowed tongue (HP:0000221)	2.03503085
60	Tongue fasciculations (HP:0001308)	2.03351036
61	Abnormality of the metopic suture (HP:0005556)	2.02732533
62	Short 1st metacarpal (HP:0010034)	2.02295866
63	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.02295866
64	Sclerocornea (HP:0000647)	2.01397050
65	Oligomenorrhea (HP:0000876)	2.00937637
66	Enlarged penis (HP:0000040)	2.00221519
67	Agitation (HP:0000713)	1.98878782
68	Postaxial hand polydactyly (HP:0001162)	1.97242284
69	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.96992778
70	Metaphyseal dysplasia (HP:0100255)	1.96670762
71	Abnormal albumin level (HP:0012116)	1.95986661
72	Hypoalbuminemia (HP:0003073)	1.95986661
73	Short tibia (HP:0005736)	1.95140598
74	Attenuation of retinal blood vessels (HP:0007843)	1.93876200
75	Broad foot (HP:0001769)	1.90916509
76	Abnormality of endocrine pancreas physiology (HP:0012093)	1.89696193
77	Abnormality of the pancreatic islet cells (HP:0006476)	1.89696193
78	Decreased testicular size (HP:0008734)	1.87722487
79	Left ventricular hypertrophy (HP:0001712)	1.87375332
80	Abnormality of vitamin metabolism (HP:0100508)	1.87347811
81	Aplasia/hypoplasia of the uterus (HP:0008684)	1.83897315
82	Abnormality of methionine metabolism (HP:0010901)	1.83320426
83	Limb dystonia (HP:0002451)	1.81334727
84	Proximal tubulopathy (HP:0000114)	1.80190955
85	Abnormality of the renal cortex (HP:0011035)	1.79950474
86	Specific learning disability (HP:0001328)	1.79456901
87	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.79150549
88	Lipid accumulation in hepatocytes (HP:0006561)	1.78871450
89	Symptomatic seizures (HP:0011145)	1.78375727
90	Hypogonadotrophic hypogonadism (HP:0000044)	1.77046774
91	Increased corneal curvature (HP:0100692)	1.76710808
92	Keratoconus (HP:0000563)	1.76710808
93	Cerebral edema (HP:0002181)	1.75106002
94	Hyperventilation (HP:0002883)	1.75013001
95	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.74360595
96	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.74360595
97	Hepatocellular necrosis (HP:0001404)	1.74048444
98	Generalized tonic-clonic seizures (HP:0002069)	1.73417608
99	Intention tremor (HP:0002080)	1.73203286
100	Abnormality of the 1st metacarpal (HP:0010009)	1.72843268

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.72105076
2	MAP4K2	4.12177499
3	FGFR2	2.86601222
4	WNK3	2.70685448
5	BCR	2.57512318
6	MST4	2.33848770
7	CASK	2.26778088
8	MAP3K4	2.25305265
9	PINK1	2.21742496
10	TRIM28	2.09892329
11	PAK3	1.96883945
12	TNIK	1.80438977
13	STK3	1.74992940
14	CSNK1G3	1.74472609
15	CSNK1G2	1.72245859
16	ERBB3	1.70082067
17	MUSK	1.64448077
18	CSNK1G1	1.63105125
19	MAP3K12	1.63035928
20	EIF2AK3	1.57569531
21	BMPR1B	1.56976044
22	MAP2K7	1.55069761
23	GRK1	1.51053756
24	LIMK1	1.50854494
25	CSNK1A1L	1.48170086
26	PHKG1	1.46412008
27	PHKG2	1.46412008
28	MAPK13	1.45088553
29	EPHA3	1.43085045
30	PLK2	1.40161007
31	PRKCE	1.39773265
32	NUAK1	1.39716051
33	ADRBK2	1.35299420
34	NTRK3	1.33421292
35	DYRK3	1.29540484
36	BCKDK	1.26321812
37	MARK1	1.24191507
38	ZAK	1.19076983
39	STK38L	1.18102581
40	FER	1.07410335
41	PLK3	0.98511575
42	MAP3K9	0.94331663
43	STK39	0.92152247
44	DYRK2	0.91859976
45	MAP3K2	0.90196963
46	PRKCG	0.90061653
47	FGFR3	0.81095101
48	EIF2AK1	0.80705143
49	CAMK2D	0.79323441
50	WNK4	0.79295008
51	OXSR1	0.74104605
52	TIE1	0.72364295
53	CSNK1A1	0.71159176
54	DAPK2	0.70083766
55	INSRR	0.65226154
56	MINK1	0.62190969
57	PIM2	0.56135001
58	STK16	0.54747071
59	PRKCI	0.54370697
60	MYLK	0.54145265
61	NTRK2	0.53565381
62	RPS6KA4	0.52446565
63	CAMK2A	0.52024332
64	EPHA4	0.47923621
65	PRKG1	0.47603940
66	TESK1	0.46753357
67	CAMK2G	0.46211902
68	ADRBK1	0.44921586
69	MKNK2	0.44245417
70	CAMKK2	0.43039650
71	CAMK2B	0.42702663
72	TNK2	0.41794357
73	ROCK1	0.39956191
74	ROCK2	0.39067945
75	PRKAA1	0.38387223
76	PRKACA	0.38248889
77	PTK2B	0.36397098
78	PLK1	0.36229387
79	CSNK1D	0.35236036
80	MAP2K4	0.34989759
81	CDK5	0.34716343
82	PRKCZ	0.34429684
83	PRKACB	0.33868262
84	CDK3	0.33857845
85	STK11	0.32573588
86	ATM	0.32242064
87	VRK2	0.29120510
88	CSNK1E	0.27904264
89	TRPM7	0.27855107
90	ABL1	0.27499874
91	STK4	0.27054227
92	UHMK1	0.26142169
93	HIPK2	0.25071570
94	PRKCA	0.24934538
95	PRKAA2	0.23612797
96	GSK3A	0.22413708
97	SGK2	0.22088727
98	PTK2	0.20760160
99	SIK3	0.20734047
100	PRKCB	0.20694815

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.93429581
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.37098161
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.32457012
4	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.79426622
5	Butanoate metabolism_Homo sapiens_hsa00650	2.68161868
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.59328287
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.51549953
8	Folate biosynthesis_Homo sapiens_hsa00790	2.36551438
9	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.26614867
10	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.03466882
11	Propanoate metabolism_Homo sapiens_hsa00640	2.02140330
12	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.99453412
13	Parkinsons disease_Homo sapiens_hsa05012	1.80667991
14	Collecting duct acid secretion_Homo sapiens_hsa04966	1.76083751
15	Phototransduction_Homo sapiens_hsa04744	1.73985826
16	Insulin secretion_Homo sapiens_hsa04911	1.65539391
17	Sulfur metabolism_Homo sapiens_hsa00920	1.60910574
18	Fatty acid elongation_Homo sapiens_hsa00062	1.51723052
19	Peroxisome_Homo sapiens_hsa04146	1.49078899
20	Steroid biosynthesis_Homo sapiens_hsa00100	1.43491949
21	Regulation of autophagy_Homo sapiens_hsa04140	1.43346417
22	Nicotine addiction_Homo sapiens_hsa05033	1.36636163
23	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.34296920
24	Basal transcription factors_Homo sapiens_hsa03022	1.28811577
25	GABAergic synapse_Homo sapiens_hsa04727	1.24124338
26	Alzheimers disease_Homo sapiens_hsa05010	1.23282098
27	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.21800668
28	Circadian rhythm_Homo sapiens_hsa04710	1.18346093
29	Nitrogen metabolism_Homo sapiens_hsa00910	1.11930379
30	Huntingtons disease_Homo sapiens_hsa05016	1.08880295
31	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.07676941
32	Tryptophan metabolism_Homo sapiens_hsa00380	1.07127440
33	RNA polymerase_Homo sapiens_hsa03020	1.05493634
34	Fanconi anemia pathway_Homo sapiens_hsa03460	1.05452700
35	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.04530655
36	Proteasome_Homo sapiens_hsa03050	1.02857884
37	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.02130851
38	Vibrio cholerae infection_Homo sapiens_hsa05110	0.98776232
39	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.98016961
40	Selenocompound metabolism_Homo sapiens_hsa00450	0.97056638
41	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.96041528
42	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.93723694
43	Glutathione metabolism_Homo sapiens_hsa00480	0.93257278
44	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.93221363
45	Taste transduction_Homo sapiens_hsa04742	0.93099563
46	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.92353378
47	beta-Alanine metabolism_Homo sapiens_hsa00410	0.89385440
48	Circadian entrainment_Homo sapiens_hsa04713	0.89227413
49	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.87226929
50	Morphine addiction_Homo sapiens_hsa05032	0.84657739
51	Cardiac muscle contraction_Homo sapiens_hsa04260	0.83358449
52	Metabolic pathways_Homo sapiens_hsa01100	0.81643707
53	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.81371336
54	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.80363293
55	Dopaminergic synapse_Homo sapiens_hsa04728	0.79264846
56	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.77458692
57	RNA degradation_Homo sapiens_hsa03018	0.77115622
58	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.74418991
59	Retinol metabolism_Homo sapiens_hsa00830	0.74116214
60	Ether lipid metabolism_Homo sapiens_hsa00565	0.71980577
61	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.71518022
62	Amphetamine addiction_Homo sapiens_hsa05031	0.69660610
63	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.69022867
64	Cocaine addiction_Homo sapiens_hsa05030	0.68838385
65	Chemical carcinogenesis_Homo sapiens_hsa05204	0.68181234
66	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.67689219
67	Sphingolipid metabolism_Homo sapiens_hsa00600	0.65690244
68	Linoleic acid metabolism_Homo sapiens_hsa00591	0.64687163
69	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.63750900
70	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.63712426
71	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.63513790
72	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.63376089
73	Serotonergic synapse_Homo sapiens_hsa04726	0.62176060
74	Fatty acid metabolism_Homo sapiens_hsa01212	0.61771436
75	Caffeine metabolism_Homo sapiens_hsa00232	0.61606559
76	ABC transporters_Homo sapiens_hsa02010	0.60616865
77	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.59382446
78	Olfactory transduction_Homo sapiens_hsa04740	0.55607440
79	Mineral absorption_Homo sapiens_hsa04978	0.53107780
80	Non-homologous end-joining_Homo sapiens_hsa03450	0.52447558
81	Arginine and proline metabolism_Homo sapiens_hsa00330	0.50124066
82	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.49901015
83	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.48396364
84	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.48032119
85	Glutamatergic synapse_Homo sapiens_hsa04724	0.47175742
86	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.47126586
87	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.44895166
88	Purine metabolism_Homo sapiens_hsa00230	0.44888536
89	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.44559360
90	Renin secretion_Homo sapiens_hsa04924	0.43935022
91	Fat digestion and absorption_Homo sapiens_hsa04975	0.39019400
92	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.38713389
93	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.38576395
94	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.36659290
95	Glucagon signaling pathway_Homo sapiens_hsa04922	0.36501796
96	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.32793918
97	Oocyte meiosis_Homo sapiens_hsa04114	0.32734646
98	Salivary secretion_Homo sapiens_hsa04970	0.32198960
99	Sulfur relay system_Homo sapiens_hsa04122	0.31045826
100	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.30932945

BMS1P9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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