ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	5.83396920
2	cardiac ventricle formation (GO:0003211)	5.34146530
3	cardiac chamber formation (GO:0003207)	5.25435205
4	nucleobase catabolic process (GO:0046113)	4.17970999
5	neural tube formation (GO:0001841)	4.14910528
6	positive regulation of heat generation (GO:0031652)	4.09214359
7	regulation of heat generation (GO:0031650)	3.94862892
8	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	3.92898944
9	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	3.92898944
10	myelin assembly (GO:0032288)	3.83345413
11	intraciliary transport (GO:0042073)	3.78465796
12	regulation of fever generation (GO:0031620)	3.73830943
13	positive regulation of mitochondrial fission (GO:0090141)	3.64799680
14	axonal fasciculation (GO:0007413)	3.59669038
15	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	3.55014516
16	ganglion development (GO:0061548)	3.45586475
17	nonmotile primary cilium assembly (GO:0035058)	3.36151932
18	regulation of synapse structural plasticity (GO:0051823)	3.33706257
19	central nervous system projection neuron axonogenesis (GO:0021952)	3.33144578
20	retinal ganglion cell axon guidance (GO:0031290)	3.14490898
21	negative regulation of mast cell activation (GO:0033004)	3.12668438
22	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	3.08809453
23	cerebral cortex cell migration (GO:0021795)	3.06276223
24	secondary heart field specification (GO:0003139)	3.05032867
25	heart field specification (GO:0003128)	3.05032867
26	retinal cone cell development (GO:0046549)	3.01583325
27	central nervous system neuron axonogenesis (GO:0021955)	3.00014052
28	positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)	2.97433147
29	protein K48-linked ubiquitination (GO:0070936)	2.97066561
30	cell migration involved in heart development (GO:0060973)	2.96764902
31	olfactory bulb development (GO:0021772)	2.96129974
32	axon extension involved in axon guidance (GO:0048846)	2.93344753
33	neuron projection extension involved in neuron projection guidance (GO:1902284)	2.93344753
34	platelet dense granule organization (GO:0060155)	2.92323655
35	glycosphingolipid biosynthetic process (GO:0006688)	2.89461715
36	negative regulation of systemic arterial blood pressure (GO:0003085)	2.82610440
37	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.82529379
38	piRNA metabolic process (GO:0034587)	2.81987543
39	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	2.80551585
40	cerebral cortex radially oriented cell migration (GO:0021799)	2.77526485
41	T-helper 1 type immune response (GO:0042088)	2.77159195
42	cerebral cortex neuron differentiation (GO:0021895)	2.76602663
43	positive regulation of amino acid transport (GO:0051957)	2.75844835
44	protein polyglutamylation (GO:0018095)	2.74219635
45	Rac protein signal transduction (GO:0016601)	2.67620043
46	positive regulation of interleukin-17 production (GO:0032740)	2.65713920
47	tyrosine phosphorylation of STAT protein (GO:0007260)	2.63470340
48	regulation of feeding behavior (GO:0060259)	2.63290802
49	regulation of development, heterochronic (GO:0040034)	2.59682309
50	regulation of glutamate secretion (GO:0014048)	2.59641238
51	regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)	2.57429832
52	positive regulation of fibroblast migration (GO:0010763)	2.53677153
53	negative regulation of axon guidance (GO:1902668)	2.53517824
54	regulation of MHC class II biosynthetic process (GO:0045346)	2.52984404
55	negative regulation of NF-kappaB import into nucleus (GO:0042347)	2.51478647
56	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.51124962
57	regulation of sarcomere organization (GO:0060297)	2.49926992
58	intracellular pH reduction (GO:0051452)	2.47403203
59	neutrophil mediated immunity (GO:0002446)	2.45620936
60	retinal rod cell development (GO:0046548)	2.45165771
61	axon extension (GO:0048675)	2.42888993
62	neuron recognition (GO:0008038)	2.42182033
63	photoreceptor cell maintenance (GO:0045494)	2.41008453
64	neuron projection extension (GO:1990138)	2.40791642
65	folic acid transport (GO:0015884)	2.40220653
66	interleukin-6-mediated signaling pathway (GO:0070102)	2.36310532
67	dendrite development (GO:0016358)	2.34050620
68	growth hormone receptor signaling pathway (GO:0060396)	2.33543890
69	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.33364405
70	sialylation (GO:0097503)	2.32830588
71	regulation of telomere maintenance via telomerase (GO:0032210)	2.31858638
72	regulation of chemokine-mediated signaling pathway (GO:0070099)	2.31535936
73	DNA integration (GO:0015074)	2.30923486
74	cell wall macromolecule catabolic process (GO:0016998)	2.30808649
75	dendrite morphogenesis (GO:0048813)	2.30406308
76	response to muramyl dipeptide (GO:0032495)	2.29335857
77	cellular response to nerve growth factor stimulus (GO:1990090)	2.28748270
78	response to nerve growth factor (GO:1990089)	2.28748270
79	vesicle fusion (GO:0006906)	2.28552276
80	regulation of interleukin-17 production (GO:0032660)	2.28482817
81	regulation of mitochondrial fission (GO:0090140)	2.27637000
82	dosage compensation (GO:0007549)	2.26915930
83	positive regulation of male gonad development (GO:2000020)	2.25622819
84	presynaptic membrane assembly (GO:0097105)	2.23203109
85	ganglioside metabolic process (GO:0001573)	2.22903218
86	cilium morphogenesis (GO:0060271)	2.21206161
87	synapsis (GO:0007129)	2.20508454
88	cilium assembly (GO:0042384)	2.20230108
89	myeloid leukocyte mediated immunity (GO:0002444)	2.20228610
90	gene silencing by RNA (GO:0031047)	2.19665701
91	nerve growth factor signaling pathway (GO:0038180)	2.19535368
92	negative regulation of amino acid transport (GO:0051956)	2.19332846
93	cilium organization (GO:0044782)	2.19066308
94	extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625)	2.18224043
95	lipopolysaccharide-mediated signaling pathway (GO:0031663)	2.17731984
96	specification of organ identity (GO:0010092)	2.17530863
97	response to lipoprotein particle (GO:0055094)	2.17066889
98	regulation of collateral sprouting (GO:0048670)	2.16671101
99	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	2.16474037
100	neuronal action potential propagation (GO:0019227)	2.15728240

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	3.76857023
2	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.36608431
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.12191060
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.99726057
5	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.95721734
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.85456512
7	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.76807419
8	TAF15_26573619_Chip-Seq_HEK293_Human	2.75152383
9	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.48470532
10	FUS_26573619_Chip-Seq_HEK293_Human	2.35004251
11	EZH2_22144423_ChIP-Seq_EOC_Human	2.19024099
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.18559349
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.15032164
14	EWS_26573619_Chip-Seq_HEK293_Human	2.12360107
15	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	2.08264225
16	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	2.06160042
17	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.05907982
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.01796784
19	P300_19829295_ChIP-Seq_ESCs_Human	1.98979695
20	SMAD4_21799915_ChIP-Seq_A2780_Human	1.95152455
21	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.92430373
22	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.82393203
23	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.78965659
24	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.78297854
25	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.77337448
26	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.77023430
27	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.74925482
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.73921941
29	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.72727886
30	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.66253945
31	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.65147126
32	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.64420876
33	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.60322756
34	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.60322756
35	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.59509519
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.59051148
37	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.59017969
38	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.52942210
39	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.46637226
40	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.45315481
41	STAT3_23295773_ChIP-Seq_U87_Human	1.44474844
42	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.42344885
43	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.40242115
44	ER_23166858_ChIP-Seq_MCF-7_Human	1.39662818
45	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.39007315
46	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.37180829
47	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.35865189
48	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.35800516
49	P53_22387025_ChIP-Seq_ESCs_Mouse	1.34923189
50	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.34167977
51	TP53_16413492_ChIP-PET_HCT116_Human	1.33025861
52	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.32254081
53	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.32161640
54	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.31753327
55	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.29933043
56	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.29701721
57	RNF2_27304074_Chip-Seq_NSC_Mouse	1.28396012
58	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.28029776
59	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.26912531
60	ELK1_19687146_ChIP-ChIP_HELA_Human	1.26319842
61	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.25035019
62	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.24405669
63	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.24127079
64	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.23456489
65	CBP_20019798_ChIP-Seq_JUKART_Human	1.22808595
66	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.22808595
67	AR_25329375_ChIP-Seq_VCAP_Human	1.22567226
68	RUNX2_22187159_ChIP-Seq_PCA_Human	1.21093534
69	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.21037661
70	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.19334593
71	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.19296842
72	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.18890360
73	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.18366305
74	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.17844178
75	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.17464579
76	TCF4_23295773_ChIP-Seq_U87_Human	1.16513959
77	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.16386932
78	TP53_18474530_ChIP-ChIP_U2OS_Human	1.14913454
79	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.13176624
80	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.12015129
81	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.09901028
82	P300_18555785_Chip-Seq_ESCs_Mouse	1.09836019
83	VDR_24787735_ChIP-Seq_THP-1_Human	1.09429641
84	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.08834056
85	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.08395590
86	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.06908578
87	KDM2B_26808549_Chip-Seq_REH_Human	1.06264130
88	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.05788579
89	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.04065973
90	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.03787357
91	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.03217297
92	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.03141661
93	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03010288
94	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.03010288
95	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02970639
96	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.02712534
97	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.02668205
98	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.02487953
99	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.02129786
100	VDR_22108803_ChIP-Seq_LS180_Human	1.01677783

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002234_abnormal_pharynx_morphology	4.20522106
2	MP0000569_abnormal_digit_pigmentation	3.61171680
3	MP0003221_abnormal_cardiomyocyte_apopto	3.24295558
4	MP0002102_abnormal_ear_morphology	3.04216886
5	MP0002822_catalepsy	2.81669554
6	MP0008789_abnormal_olfactory_epithelium	2.66028940
7	MP0002009_preneoplasia	2.65528680
8	MP0002653_abnormal_ependyma_morphology	2.48411360
9	MP0005499_abnormal_olfactory_system	2.45904652
10	MP0005394_taste/olfaction_phenotype	2.45904652
11	MP0006054_spinal_hemorrhage	2.44344208
12	MP0000778_abnormal_nervous_system	2.37336257
13	MP0005248_abnormal_Harderian_gland	2.22531430
14	MP0004510_myositis	2.18866233
15	MP0006082_CNS_inflammation	2.18334235
16	MP0008877_abnormal_DNA_methylation	2.15661721
17	MP0003303_peritoneal_inflammation	2.12167083
18	MP0003880_abnormal_central_pattern	2.09160216
19	MP0000465_gastrointestinal_hemorrhage	1.97243496
20	MP0003724_increased_susceptibility_to	1.95341705
21	MP0003787_abnormal_imprinting	1.81405513
22	MP0003121_genomic_imprinting	1.72525738
23	MP0009764_decreased_sensitivity_to	1.61884044
24	MP0002332_abnormal_exercise_endurance	1.61236415
25	MP0001529_abnormal_vocalization	1.60912898
26	MP0005253_abnormal_eye_physiology	1.59592621
27	MP0003300_gastrointestinal_ulcer	1.54724084
28	MP0010386_abnormal_urinary_bladder	1.53482830
29	MP0003828_pulmonary_edema	1.47922987
30	MP0003890_abnormal_embryonic-extraembry	1.46542500
31	MP0001984_abnormal_olfaction	1.43052138
32	MP0004084_abnormal_cardiac_muscle	1.41771768
33	MP0002837_dystrophic_cardiac_calcinosis	1.41552310
34	MP0004215_abnormal_myocardial_fiber	1.41051297
35	MP0004883_abnormal_blood_vessel	1.39610857
36	MP0003567_abnormal_fetal_cardiomyocyte	1.29678415
37	MP0002751_abnormal_autonomic_nervous	1.28708264
38	MP0000343_altered_response_to	1.26116670
39	MP0004484_altered_response_of	1.25605220
40	MP0003122_maternal_imprinting	1.22870988
41	MP0001501_abnormal_sleep_pattern	1.20722402
42	MP0002233_abnormal_nose_morphology	1.20207864
43	MP0001177_atelectasis	1.17724868
44	MP0004811_abnormal_neuron_physiology	1.16219739
45	MP0003656_abnormal_erythrocyte_physiolo	1.14316483
46	MP0009785_altered_susceptibility_to	1.12684745
47	MP0009384_cardiac_valve_regurgitation	1.12109790
48	MP0006276_abnormal_autonomic_nervous	1.12076523
49	MP0005171_absent_coat_pigmentation	1.08868302
50	MP0004142_abnormal_muscle_tone	1.06141270
51	MP0003195_calcinosis	1.05613330
52	MP0009046_muscle_twitch	1.03892532
53	MP0002972_abnormal_cardiac_muscle	1.02313081
54	MP0002063_abnormal_learning/memory/cond	0.98125006
55	MP0005167_abnormal_blood-brain_barrier	0.97807271
56	MP0005386_behavior/neurological_phenoty	0.96668249
57	MP0004924_abnormal_behavior	0.96668249
58	MP0000015_abnormal_ear_pigmentation	0.89796753
59	MP0006072_abnormal_retinal_apoptosis	0.89239659
60	MP0010368_abnormal_lymphatic_system	0.88523448
61	MP0005409_darkened_coat_color	0.87980006
62	MP0005647_abnormal_sex_gland	0.87380623
63	MP0005388_respiratory_system_phenotype	0.83553294
64	MP0002133_abnormal_respiratory_system	0.83553294
65	MP0003755_abnormal_palate_morphology	0.82322004
66	MP0002735_abnormal_chemical_nociception	0.81781925
67	MP0000750_abnormal_muscle_regeneration	0.81625434
68	MP0000955_abnormal_spinal_cord	0.80390384
69	MP0002882_abnormal_neuron_morphology	0.77051208
70	MP0003436_decreased_susceptibility_to	0.76851211
71	MP0002572_abnormal_emotion/affect_behav	0.76201840
72	MP0003635_abnormal_synaptic_transmissio	0.76181953
73	MP0005391_vision/eye_phenotype	0.76016052
74	MP0005164_abnormal_response_to	0.74788161
75	MP0005620_abnormal_muscle_contractility	0.74605933
76	MP0001851_eye_inflammation	0.73277796
77	MP0002177_abnormal_outer_ear	0.72589719
78	MP0000631_abnormal_neuroendocrine_gland	0.72328447
79	MP0000013_abnormal_adipose_tissue	0.72228499
80	MP0008004_abnormal_stomach_pH	0.71719194
81	MP0001324_abnormal_eye_pigmentation	0.71506236
82	MP0000751_myopathy	0.70873945
83	MP0005310_abnormal_salivary_gland	0.70075741
84	MP0002090_abnormal_vision	0.69170999
85	MP0002752_abnormal_somatic_nervous	0.69136116
86	MP0003137_abnormal_impulse_conducting	0.69129674
87	MP0009697_abnormal_copulation	0.68084007
88	MP0002272_abnormal_nervous_system	0.68078312
89	MP0004085_abnormal_heartbeat	0.65332094
90	MP0008874_decreased_physiological_sensi	0.65135971
91	MP0001188_hyperpigmentation	0.65118933
92	MP0001544_abnormal_cardiovascular_syste	0.64435505
93	MP0005385_cardiovascular_system_phenoty	0.64435505
94	MP0003172_abnormal_lysosome_physiology	0.64268846
95	MP0002152_abnormal_brain_morphology	0.63662879
96	MP0002419_abnormal_innate_immunity	0.63366278
97	MP0004859_abnormal_synaptic_plasticity	0.63124052
98	MP0001486_abnormal_startle_reflex	0.62475372
99	MP0009745_abnormal_behavioral_response	0.62019901
100	MP0002148_abnormal_hypersensitivity_rea	0.62018413

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Autoimmune thrombocytopenia (HP:0001973)	4.48883656
2	Congenital primary aphakia (HP:0007707)	4.13399536
3	Gait imbalance (HP:0002141)	4.12626699
4	Medial flaring of the eyebrow (HP:0010747)	4.04936598
5	Nephrogenic diabetes insipidus (HP:0009806)	3.95367616
6	Papillary thyroid carcinoma (HP:0002895)	3.90564132
7	Amyotrophic lateral sclerosis (HP:0007354)	3.80479097
8	Increased IgM level (HP:0003496)	3.66651347
9	Genital tract atresia (HP:0001827)	3.12772914
10	Poor coordination (HP:0002370)	3.09955060
11	Drooling (HP:0002307)	3.06495211
12	Vaginal atresia (HP:0000148)	3.00519801
13	Excessive salivation (HP:0003781)	2.92939526
14	Autoimmune hemolytic anemia (HP:0001890)	2.88157972
15	Retinal dysplasia (HP:0007973)	2.77782329
16	Thyroid carcinoma (HP:0002890)	2.77231302
17	Abnormality of the hip-girdle musculature (HP:0001445)	2.74948670
18	Abnormality of the musculature of the pelvis (HP:0001469)	2.74948670
19	Anterior segment dysgenesis (HP:0007700)	2.74696943
20	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.73913393
21	Cortical dysplasia (HP:0002539)	2.72058624
22	Broad foot (HP:0001769)	2.68603516
23	Mutism (HP:0002300)	2.65029312
24	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.62913841
25	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.62913841
26	Shoulder girdle muscle weakness (HP:0003547)	2.59928602
27	Aplasia/Hypoplasia of the lens (HP:0008063)	2.58612136
28	Disinhibition (HP:0000734)	2.51755856
29	Abnormality of T cell number (HP:0011839)	2.51236222
30	Abnormality of the lower motor neuron (HP:0002366)	2.50458098
31	Type II lissencephaly (HP:0007260)	2.45374352
32	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.41874054
33	Impaired vibration sensation in the lower limbs (HP:0002166)	2.40897247
34	Inappropriate behavior (HP:0000719)	2.39794759
35	Rimmed vacuoles (HP:0003805)	2.39160464
36	Specific learning disability (HP:0001328)	2.38086447
37	Abnormality of the corticospinal tract (HP:0002492)	2.36113211
38	Enlarged epiphyses (HP:0010580)	2.34994596
39	Lissencephaly (HP:0001339)	2.34180936
40	Hip dysplasia (HP:0001385)	2.32461504
41	Medulloblastoma (HP:0002885)	2.22442688
42	Exercise-induced muscle cramps (HP:0003710)	2.21599456
43	Decreased testicular size (HP:0008734)	2.18853723
44	Tubulointerstitial nephritis (HP:0001970)	2.17398734
45	Left ventricular hypertrophy (HP:0001712)	2.16581421
46	Pelvic girdle muscle weakness (HP:0003749)	2.14361564
47	Prominent supraorbital ridges (HP:0000336)	2.14107485
48	Hypoplasia of the iris (HP:0007676)	2.09611166
49	Choroideremia (HP:0001139)	2.08115160
50	Chronic hepatic failure (HP:0100626)	2.05591348
51	Absent speech (HP:0001344)	2.04845348
52	Median cleft lip (HP:0000161)	2.04660626
53	Gonadotropin excess (HP:0000837)	2.03467966
54	Thyroid-stimulating hormone excess (HP:0002925)	2.02416703
55	Micropenis (HP:0000054)	2.00936773
56	Progressive inability to walk (HP:0002505)	1.99130245
57	Abnormality of salivation (HP:0100755)	1.98485794
58	Lower limb muscle weakness (HP:0007340)	1.96847729
59	Urinary urgency (HP:0000012)	1.96117244
60	Depressed nasal tip (HP:0000437)	1.94239003
61	Chin dimple (HP:0010751)	1.93977464
62	Eosinophilia (HP:0001880)	1.93222045
63	Cerebellar dysplasia (HP:0007033)	1.93220530
64	Postaxial hand polydactyly (HP:0001162)	1.92093764
65	Ectropion (HP:0000656)	1.90619511
66	Bladder neoplasm (HP:0009725)	1.88489089
67	Bladder carcinoma (HP:0002862)	1.88489089
68	Limb-girdle muscle weakness (HP:0003325)	1.87562925
69	Polyphagia (HP:0002591)	1.85697312
70	Stomatitis (HP:0010280)	1.83517291
71	Birth length less than 3rd percentile (HP:0003561)	1.83261935
72	Short foot (HP:0001773)	1.82482544
73	Tubulointerstitial abnormality (HP:0001969)	1.81629052
74	Nephronophthisis (HP:0000090)	1.81296342
75	Volvulus (HP:0002580)	1.81132388
76	Long nose (HP:0003189)	1.80491393
77	Abnormality of the columella (HP:0009929)	1.78639184
78	Hypodontia (HP:0000668)	1.76219223
79	Widely spaced teeth (HP:0000687)	1.75797370
80	Peripheral hypomyelination (HP:0007182)	1.75404421
81	Large earlobe (HP:0009748)	1.74955691
82	Gonadal dysgenesis (HP:0000133)	1.74262997
83	Transitional cell carcinoma of the bladder (HP:0006740)	1.72924816
84	Focal motor seizures (HP:0011153)	1.71776869
85	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	1.71314383
86	Diminished motivation (HP:0000745)	1.70690451
87	Prominent nasal bridge (HP:0000426)	1.70678334
88	Abnormality of midbrain morphology (HP:0002418)	1.70532857
89	Molar tooth sign on MRI (HP:0002419)	1.70532857
90	Hypoplastic iliac wings (HP:0002866)	1.69798720
91	Abnormality of macular pigmentation (HP:0008002)	1.69105807
92	Retrobulbar optic neuritis (HP:0100654)	1.67996087
93	Optic neuritis (HP:0100653)	1.67996087
94	Pulmonary artery stenosis (HP:0004415)	1.67381046
95	True hermaphroditism (HP:0010459)	1.67027252
96	Steppage gait (HP:0003376)	1.66754554
97	Broad nasal tip (HP:0000455)	1.66172543
98	Insidious onset (HP:0003587)	1.65211993
99	Termporal pattern (HP:0011008)	1.65211993
100	Apathy (HP:0000741)	1.64898172

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.90308654
2	BCR	3.25523524
3	EPHA3	3.09248798
4	MARK1	2.81028491
5	PIK3CA	2.56518464
6	WNK3	2.50481328
7	TLK1	2.40619467
8	MAP3K4	2.36586353
9	ERBB3	2.20724106
10	TRIM28	2.20390978
11	MAP3K6	2.05555909
12	CDK19	1.97844594
13	MAPK13	1.92274986
14	CSNK1G2	1.87158415
15	GRK7	1.84206914
16	CSNK1G3	1.80575664
17	DYRK3	1.78475472
18	KSR1	1.70827115
19	PINK1	1.67344333
20	MAP2K7	1.63964128
21	CASK	1.62567276
22	CAMKK2	1.61378408
23	EPHA4	1.59871805
24	SIK3	1.58182544
25	BMPR2	1.55765738
26	CSNK1A1L	1.54363234
27	MAP2K4	1.49658805
28	MAP3K14	1.40622488
29	MAP3K5	1.37304933
30	MOS	1.37098531
31	DYRK1B	1.36620426
32	CSNK1G1	1.36133017
33	EIF2AK3	1.35601097
34	YES1	1.33637816
35	BRD4	1.30362150
36	CCNB1	1.23336229
37	RPS6KA4	1.22919171
38	UHMK1	1.05620348
39	RET	1.03547019
40	MINK1	0.92702510
41	STK38L	0.91966433
42	NEK9	0.90574994
43	MARK3	0.88302571
44	CAMK4	0.86926067
45	FRK	0.84521147
46	DDR2	0.83773849
47	PLK2	0.81025807
48	CDK6	0.80717587
49	KIT	0.80702579
50	FGR	0.76129162
51	DYRK1A	0.69611449
52	PAK3	0.65450042
53	MATK	0.65344034
54	EPHB2	0.64282598
55	CDK5	0.64212791
56	PRKCE	0.63856958
57	CDK14	0.61754137
58	NUAK1	0.61665938
59	NTRK2	0.60479169
60	IKBKE	0.60459451
61	CAMK1D	0.58024650
62	SGK2	0.57118890
63	PRKCG	0.56946942
64	MAP3K13	0.56693002
65	LATS1	0.56320303
66	KSR2	0.56102769
67	DYRK2	0.51610327
68	CAMK1G	0.51485134
69	OBSCN	0.51436980
70	TGFBR2	0.51234382
71	RAF1	0.51072112
72	PDGFRB	0.50858506
73	ABL1	0.49244758
74	MAP2K3	0.49042583
75	DAPK2	0.48597287
76	CDK18	0.46164001
77	CSNK1D	0.45476530
78	TXK	0.44840473
79	WEE1	0.44828662
80	MAPK4	0.43864938
81	JAK2	0.42985151
82	TAOK1	0.42389606
83	EGFR	0.41556083
84	AKT3	0.40933153
85	CAMK2A	0.38537944
86	OXSR1	0.38391538
87	TBK1	0.37809764
88	INSR	0.36864397
89	MKNK1	0.36607797
90	CDK15	0.36498407
91	ADRBK2	0.35457748
92	BRSK2	0.33692093
93	PKN1	0.33662727
94	CDK11A	0.32752911
95	PRKG1	0.29968899
96	FER	0.29286804
97	SRPK1	0.29190889
98	IRAK2	0.29133691
99	LCK	0.27543832
100	BCKDK	0.25767056

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	2.09389468
2	African trypanosomiasis_Homo sapiens_hsa05143	2.06128721
3	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.02329541
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.95602186
5	Legionellosis_Homo sapiens_hsa05134	1.92540947
6	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.90121358
7	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.79134123
8	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	1.69675367
9	Nicotine addiction_Homo sapiens_hsa05033	1.54845414
10	Osteoclast differentiation_Homo sapiens_hsa04380	1.52108474
11	Salmonella infection_Homo sapiens_hsa05132	1.51674859
12	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.51152778
13	TNF signaling pathway_Homo sapiens_hsa04668	1.47142540
14	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.45830204
15	Hepatitis B_Homo sapiens_hsa05161	1.45640315
16	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	1.43501524
17	Shigellosis_Homo sapiens_hsa05131	1.42794220
18	Protein export_Homo sapiens_hsa03060	1.40967544
19	GABAergic synapse_Homo sapiens_hsa04727	1.33603739
20	Malaria_Homo sapiens_hsa05144	1.32387990
21	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.32054790
22	Measles_Homo sapiens_hsa05162	1.30322019
23	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	1.28474307
24	Basal transcription factors_Homo sapiens_hsa03022	1.26766875
25	Long-term depression_Homo sapiens_hsa04730	1.20789092
26	Axon guidance_Homo sapiens_hsa04360	1.19726935
27	Prolactin signaling pathway_Homo sapiens_hsa04917	1.14137630
28	Morphine addiction_Homo sapiens_hsa05032	1.13743125
29	Influenza A_Homo sapiens_hsa05164	1.10448549
30	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.09966307
31	Circadian rhythm_Homo sapiens_hsa04710	1.07298788
32	Neurotrophin signaling pathway_Homo sapiens_hsa04722	1.06951064
33	Chemokine signaling pathway_Homo sapiens_hsa04062	1.06485185
34	Rheumatoid arthritis_Homo sapiens_hsa05323	1.06407101
35	Steroid biosynthesis_Homo sapiens_hsa00100	1.04206655
36	Tuberculosis_Homo sapiens_hsa05152	1.03917504
37	Endometrial cancer_Homo sapiens_hsa05213	1.03697243
38	Pertussis_Homo sapiens_hsa05133	1.02908193
39	Dopaminergic synapse_Homo sapiens_hsa04728	1.02815710
40	Renal cell carcinoma_Homo sapiens_hsa05211	1.02464031
41	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.98703976
42	Leishmaniasis_Homo sapiens_hsa05140	0.96544738
43	FoxO signaling pathway_Homo sapiens_hsa04068	0.93515274
44	Regulation of autophagy_Homo sapiens_hsa04140	0.92834315
45	Phagosome_Homo sapiens_hsa04145	0.92330557
46	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.89510837
47	Taste transduction_Homo sapiens_hsa04742	0.89177741
48	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.87603914
49	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.86671350
50	Colorectal cancer_Homo sapiens_hsa05210	0.86105610
51	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.85533817
52	ErbB signaling pathway_Homo sapiens_hsa04012	0.82155091
53	Gap junction_Homo sapiens_hsa04540	0.81591795
54	Glutamatergic synapse_Homo sapiens_hsa04724	0.79636098
55	Cholinergic synapse_Homo sapiens_hsa04725	0.77737659
56	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.76769515
57	mTOR signaling pathway_Homo sapiens_hsa04150	0.76207912
58	Toxoplasmosis_Homo sapiens_hsa05145	0.75688546
59	Ras signaling pathway_Homo sapiens_hsa04014	0.75422117
60	Circadian entrainment_Homo sapiens_hsa04713	0.74737529
61	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.74247238
62	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.71740349
63	Type II diabetes mellitus_Homo sapiens_hsa04930	0.69745081
64	Pancreatic cancer_Homo sapiens_hsa05212	0.69677506
65	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.68077419
66	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.66728237
67	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.66414748
68	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.65804802
69	Melanoma_Homo sapiens_hsa05218	0.64996141
70	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.64368709
71	Herpes simplex infection_Homo sapiens_hsa05168	0.63330789
72	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.63124912
73	Allograft rejection_Homo sapiens_hsa05330	0.62473934
74	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.60397858
75	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.60347892
76	Amoebiasis_Homo sapiens_hsa05146	0.59993635
77	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.59899120
78	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.59888062
79	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.59836928
80	Hepatitis C_Homo sapiens_hsa05160	0.59180661
81	cAMP signaling pathway_Homo sapiens_hsa04024	0.58492661
82	mRNA surveillance pathway_Homo sapiens_hsa03015	0.58263052
83	Type I diabetes mellitus_Homo sapiens_hsa04940	0.58147913
84	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.58097224
85	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.58056799
86	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.57762709
87	Non-small cell lung cancer_Homo sapiens_hsa05223	0.57083040
88	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.56980465
89	Serotonergic synapse_Homo sapiens_hsa04726	0.56615278
90	Graft-versus-host disease_Homo sapiens_hsa05332	0.56427037
91	Glioma_Homo sapiens_hsa05214	0.56416176
92	Renin secretion_Homo sapiens_hsa04924	0.55560251
93	Cocaine addiction_Homo sapiens_hsa05030	0.55341792
94	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.54615523
95	Platelet activation_Homo sapiens_hsa04611	0.53899692
96	Choline metabolism in cancer_Homo sapiens_hsa05231	0.53759181
97	Estrogen signaling pathway_Homo sapiens_hsa04915	0.53172815
98	MAPK signaling pathway_Homo sapiens_hsa04010	0.53038481
99	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.51893137
100	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.50977052

BMT2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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