BMX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular extravasation (GO:0045123)8.06853987
2production of molecular mediator involved in inflammatory response (GO:0002532)7.06639492
3neutrophil mediated immunity (GO:0002446)6.70361590
4leukocyte aggregation (GO:0070486)6.46977151
5leukocyte migration involved in inflammatory response (GO:0002523)6.40464457
6defense response to fungus (GO:0050832)6.37890020
7neutrophil activation involved in immune response (GO:0002283)6.15248815
8macrophage differentiation (GO:0030225)5.78379512
9detection of bacterium (GO:0016045)5.77210989
10detection of other organism (GO:0098543)5.69661718
11lymphangiogenesis (GO:0001946)5.65486248
12response to fungus (GO:0009620)5.54590860
13positive regulation of mast cell activation (GO:0033005)5.54009743
14respiratory burst (GO:0045730)5.38733508
15disruption of cells of other organism involved in symbiotic interaction (GO:0051818)5.18141891
16killing of cells in other organism involved in symbiotic interaction (GO:0051883)5.18141891
17positive regulation of endothelial cell differentiation (GO:0045603)5.13674204
18myeloid leukocyte mediated immunity (GO:0002444)5.12511009
19neutrophil activation (GO:0042119)5.01884841
20regulation of nitric-oxide synthase biosynthetic process (GO:0051769)4.88974722
21regulation of B cell receptor signaling pathway (GO:0050855)4.83841727
22sequestering of metal ion (GO:0051238)4.81106403
23neutrophil chemotaxis (GO:0030593)4.71800217
24positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.70840192
25wound healing, spreading of epidermal cells (GO:0035313)4.66260921
26negative regulation of blood vessel endothelial cell migration (GO:0043537)4.65816771
27neutrophil migration (GO:1990266)4.58950687
28granulocyte activation (GO:0036230)4.57247711
29regulation of mast cell activation (GO:0033003)4.56910703
30positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.47993833
31negative regulation of phagocytosis (GO:0050765)4.45162269
32regulation of interferon-beta biosynthetic process (GO:0045357)4.41589008
33regulation of myeloid leukocyte mediated immunity (GO:0002886)4.34434643
34detection of molecule of bacterial origin (GO:0032490)4.33994957
35negative regulation of focal adhesion assembly (GO:0051895)4.33896409
36negative regulation of cell junction assembly (GO:1901889)4.33896409
37negative regulation of adherens junction organization (GO:1903392)4.33896409
38retina vasculature morphogenesis in camera-type eye (GO:0061299)4.21613551
39positive regulation of interleukin-8 secretion (GO:2000484)4.15490465
40regulation of endothelial cell differentiation (GO:0045601)4.12964694
41response to peptidoglycan (GO:0032494)4.12625248
42regulation of leukocyte degranulation (GO:0043300)4.11430168
43negative regulation of endothelial cell migration (GO:0010596)4.08389048
44endodermal cell differentiation (GO:0035987)4.08006580
45regulation of mast cell degranulation (GO:0043304)4.07828471
46granulocyte chemotaxis (GO:0071621)4.02511293
47regulation of receptor binding (GO:1900120)4.01288850
48negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.00690228
49granulocyte migration (GO:0097530)3.91434043
50lipoxygenase pathway (GO:0019372)3.90129572
51leukotriene biosynthetic process (GO:0019370)3.88802736
52positive regulation of mast cell activation involved in immune response (GO:0033008)3.85901973
53positive regulation of mast cell degranulation (GO:0043306)3.85901973
54regulation of mast cell activation involved in immune response (GO:0033006)3.83719617
55disruption of cells of other organism (GO:0044364)3.81884436
56killing of cells of other organism (GO:0031640)3.81884436
57chondrocyte proliferation (GO:0035988)3.75212957
58regulation of systemic arterial blood pressure by hormone (GO:0001990)3.73317397
59regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.73317397
60endocrine process (GO:0050886)3.73317397
61negative regulation of mast cell activation (GO:0033004)3.70196244
62regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.69519706
63regulation of regulated secretory pathway (GO:1903305)3.68849830
64macrophage activation (GO:0042116)3.68183057
65positive regulation of urine volume (GO:0035810)3.63349612
66angiogenesis involved in wound healing (GO:0060055)3.61094128
67artery development (GO:0060840)3.59237352
68leukotriene metabolic process (GO:0006691)3.58448192
69response to host immune response (GO:0052572)3.55995699
70response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.55995699
71positive regulation of lamellipodium assembly (GO:0010592)3.55797847
72negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.55078909
73response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.54606629
74response to host (GO:0075136)3.54606629
75response to host defenses (GO:0052200)3.54606629
76dendritic cell chemotaxis (GO:0002407)3.50326917
77pentose-phosphate shunt (GO:0006098)3.49964226
78macrophage activation involved in immune response (GO:0002281)3.41029581
79regulation of dendritic cell antigen processing and presentation (GO:0002604)3.38000176
80leukocyte degranulation (GO:0043299)3.37740525
81dendritic cell migration (GO:0036336)3.36796790
82Arp2/3 complex-mediated actin nucleation (GO:0034314)3.36786655
83superoxide anion generation (GO:0042554)3.35725155
84endothelial cell differentiation (GO:0045446)3.35670211
85positive regulation of receptor recycling (GO:0001921)3.33607764
86endothelial tube morphogenesis (GO:0061154)3.31033368
87morphogenesis of an endothelium (GO:0003159)3.31033368
88immunoglobulin mediated immune response (GO:0016064)3.29174003
89regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.29146016
90regulation of interleukin-8 secretion (GO:2000482)3.28321633
91positive regulation of macrophage activation (GO:0043032)3.27424286
92detection of external biotic stimulus (GO:0098581)3.26589643
93lymph vessel development (GO:0001945)3.26178917
94leukocyte cell-cell adhesion (GO:0007159)3.25846511
95regulation of natural killer cell differentiation (GO:0032823)3.23020651
96defense response to Gram-positive bacterium (GO:0050830)3.21424745
97positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.20649320
98regulation of blood vessel endothelial cell migration (GO:0043535)3.19784392
99leukocyte mediated cytotoxicity (GO:0001909)3.17849407
100endothelium development (GO:0003158)3.16537378
101negative regulation of interleukin-12 production (GO:0032695)3.15876319
102sprouting angiogenesis (GO:0002040)3.15602630
103positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.14763586
104NADPH regeneration (GO:0006740)3.12037198
105positive regulation of vesicle fusion (GO:0031340)3.09649111
106positive regulation of gamma-delta T cell activation (GO:0046645)3.08831078
107diterpenoid biosynthetic process (GO:0016102)3.07537245
108wound healing, spreading of cells (GO:0044319)3.06583763
109myeloid leukocyte migration (GO:0097529)3.05329966
110adaptation of signaling pathway (GO:0023058)3.04491642
111regulation of sarcomere organization (GO:0060297)3.00317614
112positive regulation of fibroblast migration (GO:0010763)2.97372573
113antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.96072753
114negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.94329488
115negative regulation of cell killing (GO:0031342)2.94329488
116microglial cell activation (GO:0001774)2.92986590
117positive regulation of chemokine secretion (GO:0090197)2.91812042
118positive regulation of lamellipodium organization (GO:1902745)2.91251149
119chronic inflammatory response (GO:0002544)2.89555220
120regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.89297511
121leukocyte chemotaxis (GO:0030595)2.88550944
122substrate-dependent cell migration (GO:0006929)2.88149354
123blood vessel maturation (GO:0001955)2.87831389
124regulation of systemic arterial blood pressure (GO:0003073)2.84641218
125negative regulation of fibrinolysis (GO:0051918)2.84451983
126reactive oxygen species biosynthetic process (GO:1903409)2.84209824
127hepatocyte apoptotic process (GO:0097284)2.83346949
128positive regulation of leukocyte degranulation (GO:0043302)2.82205440
129positive regulation of blood vessel endothelial cell migration (GO:0043536)2.82166271
130negative regulation of interleukin-8 production (GO:0032717)2.81651268
131phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.81092468
132regulation of endothelial cell migration (GO:0010594)2.79714638
133vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.78443342
134regulation of vasculogenesis (GO:2001212)2.78257031
135negative regulation of cell-matrix adhesion (GO:0001953)2.74361856
136negative regulation of fatty acid transport (GO:2000192)2.73919408
137regulation of chemokine secretion (GO:0090196)2.73891983
138positive regulation of toll-like receptor signaling pathway (GO:0034123)2.73511118
139phospholipid scrambling (GO:0017121)2.73149055
140modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.73138537
141modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.73138537
142positive regulation by organism of defense response of other organism involved in symbiotic interact2.73138537
143modulation by symbiont of host immune response (GO:0052553)2.73138537
144positive regulation by symbiont of host defense response (GO:0052509)2.73138537
145modulation by symbiont of host defense response (GO:0052031)2.73138537
146positive regulation of osteoblast proliferation (GO:0033690)2.71848179
147positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.71217507
148establishment of endothelial barrier (GO:0061028)2.68854053
149negative regulation of erythrocyte differentiation (GO:0045647)2.68743177
150negative regulation of glial cell proliferation (GO:0060253)2.68570749
151mucosal immune response (GO:0002385)2.68548790
152growth hormone receptor signaling pathway (GO:0060396)2.67458637
153negative regulation of epithelial cell migration (GO:0010633)2.67377213
154positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.66041214
155regulation of female receptivity (GO:0045924)2.65986011
156regulation of urine volume (GO:0035809)2.65918082
157regulation of transforming growth factor beta1 production (GO:0032908)2.65790332
158anatomical structure maturation (GO:0071695)2.64879248
159G-protein coupled receptor internalization (GO:0002031)2.64205241
160myeloid cell activation involved in immune response (GO:0002275)2.64102590
161positive regulation of endothelial cell migration (GO:0010595)2.63718367
162negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.63143350
163antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.62935553
164regulation of macrophage chemotaxis (GO:0010758)2.62062702
165detection of biotic stimulus (GO:0009595)2.61773979
166response to muramyl dipeptide (GO:0032495)2.61717409
167lipopolysaccharide-mediated signaling pathway (GO:0031663)2.61240250
168histamine secretion (GO:0001821)2.60734569
169neuron remodeling (GO:0016322)2.59744248
170actin filament depolymerization (GO:0030042)2.54500291
171necroptotic process (GO:0070266)2.52840619
172organ or tissue specific immune response (GO:0002251)2.50405677

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.83567942
2MYB_21317192_ChIP-Seq_ERMYB_Mouse4.33719181
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.84788913
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.49939524
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.45985470
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.35496779
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.15830614
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.15080586
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.92703758
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.85207680
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.81047466
12* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.74552684
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.64340246
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.54760784
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.50861014
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.29086674
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.21084650
18SCL_19346495_ChIP-Seq_HPC-7_Human2.20487731
19GATA2_21666600_ChIP-Seq_HMVEC_Human2.16871036
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.15644171
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.09609147
22SPI1_23127762_ChIP-Seq_K562_Human2.03983418
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.93333107
24SPI1_23547873_ChIP-Seq_NB4_Human1.92584359
25VDR_21846776_ChIP-Seq_THP-1_Human1.88003881
26VDR_24763502_ChIP-Seq_THP-1_Human1.81822218
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.75437383
28IRF8_22096565_ChIP-ChIP_GC-B_Human1.75258480
29RUNX1_22412390_ChIP-Seq_EML_Mouse1.74844999
30MYB_26560356_Chip-Seq_TH2_Human1.74137432
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.73981204
32RUNX_20019798_ChIP-Seq_JUKART_Human1.62716406
33MAF_26560356_Chip-Seq_TH1_Human1.61145305
34STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.60603479
35VDR_24787735_ChIP-Seq_THP-1_Human1.59801645
36PU_27001747_Chip-Seq_BMDM_Mouse1.52767125
37UTX_26944678_Chip-Seq_JUKART_Human1.51599419
38TCF7_22412390_ChIP-Seq_EML_Mouse1.49184153
39LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.45709013
40TRIM28_21343339_ChIP-Seq_HEK293_Human1.45527672
41GATA2_19941826_ChIP-Seq_K562_Human1.42190245
42CLOCK_20551151_ChIP-Seq_293T_Human1.40522060
43STAT4_19710469_ChIP-ChIP_TH1__Mouse1.36830174
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.36453929
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36274439
46MYB_26560356_Chip-Seq_TH1_Human1.33842810
47GATA1_19941826_ChIP-Seq_K562_Human1.33497472
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33072583
49GATA3_27048872_Chip-Seq_THYMUS_Human1.32471958
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32387036
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31988908
52MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31125029
53SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31109084
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.30935656
55CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27774692
56PPAR_26484153_Chip-Seq_NCI-H1993_Human1.27714505
57ESR1_20079471_ChIP-ChIP_T-47D_Human1.27253244
58SALL4_18804426_ChIP-ChIP_XEN_Mouse1.23012816
59GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.22669930
60BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21634942
61GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19394488
62SOX2_20726797_ChIP-Seq_SW620_Human1.18618473
63E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.17846864
64GATA1_19941827_ChIP-Seq_MEL_Mouse1.17650321
65GATA3_26560356_Chip-Seq_TH2_Human1.15623311
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14272047
67SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.13076151
68FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12336539
69GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11979099
70NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11648292
71CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11391230
72CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10970150
73MYC_22102868_ChIP-Seq_BL_Human1.10504299
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08283144
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08272860
76CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05307399
77NCOR1_26117541_ChIP-Seq_K562_Human1.05220587
78FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.04455684
79PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04272616
80PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04130350
81SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.03993306
82SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.03993306
83LXR_22292898_ChIP-Seq_THP-1_Human1.03934223
84TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02576587
85KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02310674
86PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02303307
87GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01518361
88ESR2_21235772_ChIP-Seq_MCF-7_Human0.98242506
89ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97641328
90KDM2B_26808549_Chip-Seq_DND41_Human0.97031355
91NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.96740554
92GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96702764
93LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96228258
94PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96129852
95GATA1_19941827_ChIP-Seq_MEL86_Mouse0.95319664
96SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95211337
97KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94749940
98RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.94575235
99FOXO3_23340844_ChIP-Seq_DLD1_Human0.93365008
100CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.92513181
101SPI1_20517297_ChIP-Seq_HL60_Human0.92255789
102CJUN_26792858_Chip-Seq_BT549_Human0.91800381
103IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.90798863
104TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.90195294
105TBX20_22080862_ChIP-Seq_HEART_Mouse0.89873598
106TBX20_22328084_ChIP-Seq_HEART_Mouse0.89873598
107ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89663339
108CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89595446
109SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88921393
110ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88905361
111RACK7_27058665_Chip-Seq_MCF-7_Human0.88116255
112RXR_22108803_ChIP-Seq_LS180_Human0.88096123
113SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.88020297
114RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87829062
115JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83398426
116ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.80587182
117KDM2B_26808549_Chip-Seq_JURKAT_Human0.79702275
118P300_27058665_Chip-Seq_ZR-75-30cells_Human0.79373419
119EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.78824628

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009278_abnormal_bone_marrow5.02766723
2MP0002837_dystrophic_cardiac_calcinosis4.79998326
3MP0005167_abnormal_blood-brain_barrier4.22498271
4MP0003436_decreased_susceptibility_to3.92623724
5MP0003303_peritoneal_inflammation3.54714028
6MP0003724_increased_susceptibility_to3.30755292
7MP0005397_hematopoietic_system_phenotyp2.91571079
8MP0001545_abnormal_hematopoietic_system2.91571079
9MP0000343_altered_response_to2.79578336
10MP0009785_altered_susceptibility_to2.77099400
11MP0004858_abnormal_nervous_system2.67842383
12MP0002419_abnormal_innate_immunity2.60518317
13MP0003183_abnormal_peptide_metabolism2.59161010
14MP0003828_pulmonary_edema2.57271390
15MP0003279_aneurysm2.45763250
16MP0004883_abnormal_blood_vessel2.42588532
17MP0003075_altered_response_to2.32742547
18MP0001853_heart_inflammation2.30264233
19MP0008004_abnormal_stomach_pH2.24388136
20MP0001533_abnormal_skeleton_physiology2.18777908
21MP0002277_abnormal_respiratory_mucosa2.17587614
22MP0009764_decreased_sensitivity_to2.11964950
23MP0002148_abnormal_hypersensitivity_rea2.11888822
24MP0004233_abnormal_muscle_weight2.05730782
25MP0005025_abnormal_response_to1.91391134
26MP0003705_abnormal_hypodermis_morpholog1.86432155
27MP0003300_gastrointestinal_ulcer1.84154102
28MP0004808_abnormal_hematopoietic_stem1.81773949
29MP0005164_abnormal_response_to1.80845586
30MP0002405_respiratory_system_inflammati1.76031061
31MP0003566_abnormal_cell_adhesion1.69916418
32MP0005166_decreased_susceptibility_to1.69191245
33MP0010368_abnormal_lymphatic_system1.66218798
34MP0002396_abnormal_hematopoietic_system1.63511999
35MP0000465_gastrointestinal_hemorrhage1.63436502
36MP0005000_abnormal_immune_tolerance1.62077147
37MP0000858_altered_metastatic_potential1.60165997
38MP0001851_eye_inflammation1.53722002
39MP0005023_abnormal_wound_healing1.53210487
40MP0001819_abnormal_immune_cell1.48336697
41MP0005464_abnormal_platelet_physiology1.48288484
42MP0002933_joint_inflammation1.47373158
43MP0002420_abnormal_adaptive_immunity1.46448358
44MP0001845_abnormal_inflammatory_respons1.46061465
45MP0002452_abnormal_antigen_presenting1.41235981
46MP0003448_altered_tumor_morphology1.39899530
47MP0001958_emphysema1.37786758
48MP0003950_abnormal_plasma_membrane1.35478922
49MP0010155_abnormal_intestine_physiology1.31136174
50MP0004145_abnormal_muscle_electrophysio1.30727087
51MP0002127_abnormal_cardiovascular_syste1.30550419
52MP0003191_abnormal_cellular_cholesterol1.30337335
53MP0004510_myositis1.27852814
54MP0001835_abnormal_antigen_presentation1.27147933
55MP0001800_abnormal_humoral_immune1.26042625
56MP0002132_abnormal_respiratory_system1.25839068
57MP0003045_fibrosis1.24506678
58MP0000685_abnormal_immune_system1.24278266
59MP0002332_abnormal_exercise_endurance1.21954637
60MP0010352_gastrointestinal_tract_polyps1.21857993
61MP0001986_abnormal_taste_sensitivity1.20688897
62MP0001915_intracranial_hemorrhage1.17876379
63MP0002723_abnormal_immune_serum1.17751748
64MP0002877_abnormal_melanocyte_morpholog1.16271733
65MP0001879_abnormal_lymphatic_vessel1.16123905
66MP0002138_abnormal_hepatobiliary_system1.14939760
67MP0001873_stomach_inflammation1.14304085
68MP0005645_abnormal_hypothalamus_physiol1.13762023
69MP0003453_abnormal_keratinocyte_physiol1.12929745
70MP0001790_abnormal_immune_system1.10742538
71MP0005387_immune_system_phenotype1.10742538
72MP0002133_abnormal_respiratory_system1.10294795
73MP0005388_respiratory_system_phenotype1.10294795
74MP0001348_abnormal_lacrimal_gland1.07751643
75MP0003091_abnormal_cell_migration1.05447728
76MP0003638_abnormal_response/metabolism_1.03710785
77MP0005409_darkened_coat_color1.02730973
78MP0004215_abnormal_myocardial_fiber1.02138360
79MP0004484_altered_response_of1.02031892
80MP0005390_skeleton_phenotype1.01936936
81MP0000249_abnormal_blood_vessel1.01179657
82MP0004084_abnormal_cardiac_muscle1.00913935
83MP0003221_abnormal_cardiomyocyte_apopto1.00284096
84MP0005451_abnormal_body_composition0.96210977
85MP0000716_abnormal_immune_system0.95646040
86MP0000678_abnormal_parathyroid_gland0.94531779
87MP0002972_abnormal_cardiac_muscle0.94305902
88MP0005595_abnormal_vascular_smooth0.93853685
89MP0002398_abnormal_bone_marrow0.88887247
90MP0005076_abnormal_cell_differentiation0.88310849
91MP0008260_abnormal_autophagy0.86671650
92MP0003868_abnormal_feces_composition0.86290450
93MP0008469_abnormal_protein_level0.86157084
94MP0004782_abnormal_surfactant_physiolog0.85449222
95MP0002166_altered_tumor_susceptibility0.84101036
96MP0002168_other_aberrant_phenotype0.83018649
97MP0002925_abnormal_cardiovascular_devel0.82341905
98MP0002128_abnormal_blood_circulation0.81973256
99MP0006082_CNS_inflammation0.81377041
100MP0002429_abnormal_blood_cell0.81076884
101MP0010234_abnormal_vibrissa_follicle0.79976852
102MP0005385_cardiovascular_system_phenoty0.79357374
103MP0001544_abnormal_cardiovascular_syste0.79357374
104MP0010630_abnormal_cardiac_muscle0.76127387
105MP0001346_abnormal_lacrimal_gland0.75405202
106MP0005165_increased_susceptibility_to0.75242235
107MP0000767_abnormal_smooth_muscle0.75167635
108MP0009763_increased_sensitivity_to0.73337119
109MP0002295_abnormal_pulmonary_circulatio0.73265680
110MP0004947_skin_inflammation0.72893298
111MP0004272_abnormal_basement_membrane0.72779441
112MP0001663_abnormal_digestive_system0.68959280
113MP0005310_abnormal_salivary_gland0.68926154
114MP0000689_abnormal_spleen_morphology0.68861429
115MP0006138_congestive_heart_failure0.68082529
116MP0006276_abnormal_autonomic_nervous0.67996395
117MP0006054_spinal_hemorrhage0.67123244
118MP0005671_abnormal_response_to0.67059395
119MP0003172_abnormal_lysosome_physiology0.66828560
120MP0001614_abnormal_blood_vessel0.66717772
121MP0002722_abnormal_immune_system0.65502029
122MP0002282_abnormal_trachea_morphology0.64933604
123MP0004036_abnormal_muscle_relaxation0.64620413
124MP0001849_ear_inflammation0.64097726
125MP0005360_urolithiasis0.63576075
126MP0008961_abnormal_basal_metabolism0.63016251
127MP0005084_abnormal_gallbladder_morpholo0.61463195
128MP0001175_abnormal_lung_morphology0.61298506
129MP0000516_abnormal_urinary_system0.60578801

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)8.00283273
2Recurrent abscess formation (HP:0002722)7.72302048
3Spontaneous hematomas (HP:0007420)7.16968896
4Recurrent gram-negative bacterial infections (HP:0005420)7.10925967
5Recurrent bacterial skin infections (HP:0005406)6.22823553
6Obstructive lung disease (HP:0006536)5.13397230
7Chronic obstructive pulmonary disease (HP:0006510)5.13397230
8Abnormality of macrophages (HP:0004311)4.54134695
9Hematochezia (HP:0002573)4.33917043
10Mediastinal lymphadenopathy (HP:0100721)4.33621311
11Gingivitis (HP:0000230)4.18439953
12Myositis (HP:0100614)4.17373903
13Menorrhagia (HP:0000132)4.12373021
14Abnormal platelet function (HP:0011869)3.88112674
15Impaired platelet aggregation (HP:0003540)3.88112674
16Urticaria (HP:0001025)3.83003736
17Recurrent skin infections (HP:0001581)3.69025680
18Recurrent fungal infections (HP:0002841)3.54658662
19Stomatitis (HP:0010280)3.37600559
20Cellulitis (HP:0100658)3.29819005
21Abnormality of the nasal mucosa (HP:0000433)3.23977320
22Pigmentary retinal degeneration (HP:0001146)3.16848257
23Skull defect (HP:0001362)3.11305771
24Esophageal varix (HP:0002040)3.10780392
25Orchitis (HP:0100796)3.07965593
26Ventricular tachycardia (HP:0004756)3.04518986
27Papilledema (HP:0001085)3.04237520
28Abnormality of the hepatic vasculature (HP:0006707)2.99961671
29Interstitial pulmonary disease (HP:0006530)2.96879386
30Abnormal vertebral ossification (HP:0100569)2.86954512
31Metaphyseal irregularity (HP:0003025)2.86638569
32Muscle fiber splitting (HP:0003555)2.85414042
33Thickened calvaria (HP:0002684)2.84639269
34Difficulty running (HP:0009046)2.84473808
35Short femoral neck (HP:0100864)2.80362169
36Meningitis (HP:0001287)2.78369608
37Right ventricular cardiomyopathy (HP:0011663)2.75075849
38Centrally nucleated skeletal muscle fibers (HP:0003687)2.72656098
39Polycythemia (HP:0001901)2.72277673
40Pulmonary embolism (HP:0002204)2.67500760
41Stenosis of the external auditory canal (HP:0000402)2.66966923
42Wrist flexion contracture (HP:0001239)2.64419008
43Protrusio acetabuli (HP:0003179)2.62875874
44Abnormal platelet volume (HP:0011876)2.59915007
45Spondylolisthesis (HP:0003302)2.56587748
46Increased connective tissue (HP:0009025)2.55635221
47Hypertensive crisis (HP:0100735)2.53195666
48Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.51768661
49Adactyly (HP:0009776)2.51130456
50Epistaxis (HP:0000421)2.45648647
51Subcapsular cataract (HP:0000523)2.40052629
52Hepatosplenomegaly (HP:0001433)2.39292391
53Hyporeflexia of lower limbs (HP:0002600)2.35637224
54Lymphangioma (HP:0100764)2.35308290
55Periodontitis (HP:0000704)2.34553855
56Chest pain (HP:0100749)2.34168536
57Difficulty climbing stairs (HP:0003551)2.33341721
58Elevated erythrocyte sedimentation rate (HP:0003565)2.31777392
59Aplasia/hypoplasia of the femur (HP:0005613)2.27753246
60Keratoconjunctivitis (HP:0001096)2.27604418
61Prolonged bleeding time (HP:0003010)2.26849354
62Chronic mucocutaneous candidiasis (HP:0002728)2.26578293
63Recurrent cutaneous fungal infections (HP:0011370)2.26578293
64Hemoptysis (HP:0002105)2.25443121
65Autoimmune thrombocytopenia (HP:0001973)2.24278098
66Asymmetry of the thorax (HP:0001555)2.24113225
67Vacuolated lymphocytes (HP:0001922)2.23649386
68Hypochromic microcytic anemia (HP:0004840)2.19945181
69Overgrowth (HP:0001548)2.17088510
70Hemorrhage of the eye (HP:0011885)2.16753382
71Skin ulcer (HP:0200042)2.16611411
72Absent hand (HP:0004050)2.16082813
73Thrombophlebitis (HP:0004418)2.14845187
74Pustule (HP:0200039)2.12467436
75Abnormality of the intrinsic pathway (HP:0010989)2.11568302
76Pulmonary hypertension (HP:0002092)2.10938045
77Keratitis (HP:0000491)2.10937187
78Abnormal foot bone ossification (HP:0010675)2.10394605
79Abnormal delayed hypersensitivity skin test (HP:0002963)2.09696642
80Cerebral aneurysm (HP:0004944)2.09125977
81Increased mean platelet volume (HP:0011877)2.08873444
82Osteomyelitis (HP:0002754)2.08390606
83Peritonitis (HP:0002586)2.07733106
84Gingival bleeding (HP:0000225)2.07667981
85Inflammation of the large intestine (HP:0002037)2.07065211
86Mucosal telangiectasiae (HP:0100579)2.05354980
87Broad face (HP:0000283)2.05073205
88Arterial tortuosity (HP:0005116)2.04788817
89Mitral valve prolapse (HP:0001634)2.03680139
90Abnormality of the peritoneum (HP:0002585)2.02539434
91Sepsis (HP:0100806)2.01912184
92Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.01408118
93Keratoconjunctivitis sicca (HP:0001097)2.01117034
94Chronic otitis media (HP:0000389)1.99344329
95Gastrointestinal infarctions (HP:0005244)1.99198674
96Weak cry (HP:0001612)1.97897693
97Visceral angiomatosis (HP:0100761)1.97287981
98IgM deficiency (HP:0002850)1.96352798
99Vascular tortuosity (HP:0004948)1.94696758
100Abnormality of skeletal muscle fiber size (HP:0012084)1.92910677
101Arterial thrombosis (HP:0004420)1.92891967
102Increased variability in muscle fiber diameter (HP:0003557)1.92830373
103Orthostatic hypotension (HP:0001278)1.91499887
104Abnormality of the vasculature of the conjunctiva (HP:0008054)1.90484019
105Gastrointestinal inflammation (HP:0004386)1.90227437
106Amyloidosis (HP:0011034)1.89826632
107Conjunctival telangiectasia (HP:0000524)1.88856489
108Exercise-induced muscle cramps (HP:0003710)1.88365170
109Teleangiectasia of the skin (HP:0100585)1.87977031
110Vertigo (HP:0002321)1.87396362
111Abnormality of the common coagulation pathway (HP:0010990)1.87139677
112Recurrent corneal erosions (HP:0000495)1.87013737
113Aortic valve stenosis (HP:0001650)1.86750241
114Cheilitis (HP:0100825)1.85731394
115Joint hemorrhage (HP:0005261)1.85590739
116Hemangiomatosis (HP:0007461)1.85500250
117Hypochromic anemia (HP:0001931)1.83675423
118Porencephaly (HP:0002132)1.82160814
119Petechiae (HP:0000967)1.82074608
120Male infertility (HP:0003251)1.81234476
121Increased IgE level (HP:0003212)1.80597039
122Aortic aneurysm (HP:0004942)1.80277787
123Venous insufficiency (HP:0005293)1.79703913
124Recurrent pneumonia (HP:0006532)1.78944940
125Stroke (HP:0001297)1.78215228
126Nonimmune hydrops fetalis (HP:0001790)1.77565979
127Vertebral clefting (HP:0008428)1.76634890
128Subacute progressive viral hepatitis (HP:0006572)1.76422868
129Vasculitis (HP:0002633)1.75697253
130Portal hypertension (HP:0001409)1.73033371
131Tinnitus (HP:0000360)1.72772940
132Episodic fever (HP:0001954)1.72753018
133Cerebral hemorrhage (HP:0001342)1.72029844
134Retrobulbar optic neuritis (HP:0100654)1.71348508
135Optic neuritis (HP:0100653)1.71348508
136Microcytic anemia (HP:0001935)1.69826017
137Neonatal death (HP:0003811)1.69282779
138Nasal polyposis (HP:0100582)1.69027612
139Long clavicles (HP:0000890)1.67939300
140Thoracic kyphosis (HP:0002942)1.67117700
141High pitched voice (HP:0001620)1.63745656
142Abnormality of the endocardium (HP:0004306)1.62031806
143Leukocytosis (HP:0001974)1.61965738
144Lipoatrophy (HP:0100578)1.61740879
145Cavernous hemangioma (HP:0001048)1.60525662

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K33.52236426
2STK103.50792631
3EPHB13.45792584
4TRPM73.36137180
5IRAK43.18668582
6TGFBR23.09953771
7ERBB32.98433037
8CSK2.85762109
9BLK2.65551516
10ERN12.60634729
11TIE12.53539347
12FER2.11323886
13FGR2.07242295
14KDR2.05605864
15MAP3K32.01313768
16MAP3K121.96917184
17TAOK11.87858332
18RIPK11.83722439
19DMPK1.76340964
20KSR21.76240303
21LRRK21.75413874
22CLK11.75011054
23HCK1.70119156
24EPHB21.66636121
25MAP3K61.62001250
26MYLK1.60206086
27DAPK21.54027353
28FES1.53916257
29PTK61.47115259
30JAK31.46568992
31MOS1.45752146
32STK241.45448629
33RIPK41.42919265
34TRIB31.41559229
35PAK41.36326590
36TGFBR11.30735572
37ZAP701.30580848
38GRK71.22423005
39PRKG21.19344453
40GRK61.18981639
41* BTK1.18098892
42PTK2B1.15530897
43TTN1.11676854
44TESK11.06288046
45MAPKAPK21.04640926
46IRAK11.01281382
47MAP3K111.00425282
48PKN20.98888306
49RAF10.95636150
50IRAK30.94995176
51FRK0.93694509
52TYK20.92359716
53RPS6KA40.90478223
54MAP3K90.86747216
55JAK20.81184537
56YES10.81050672
57SGK30.80669999
58GRK50.80146297
59SGK20.79600335
60TNK20.79027259
61MAP2K60.78535283
62MARK20.74880886
63PIK3CG0.74609483
64TBK10.73671961
65TAOK30.73278289
66PRKD30.69167450
67IRAK20.68544200
68MAPKAPK50.67783918
69LIMK10.67652162
70MAPKAPK30.67500524
71* TEC0.66621151
72RPS6KB20.64341831
73MATK0.64053299
74CDK90.63426124
75MAP3K10.59462668
76RPS6KA20.58753921
77MAPK150.58255636
78RPS6KC10.55301331
79RPS6KL10.55301331
80GRK10.54892176
81RPS6KA60.54628161
82MAP3K140.54329068
83JAK10.54277049
84MAP4K10.53263416
85MAP3K20.52284294
86FGFR40.51214748
87FYN0.50776198
88IKBKE0.50048280
89EIF2AK20.49668892
90MAP3K80.49238256
91MAPK120.45982045
92FGFR20.45627326
93SMG10.45157800
94PRKD10.44004414
95EGFR0.42862292
96FGFR30.41152334
97PDPK10.40658028
98RET0.40655339
99PRKD20.38037692
100MAP2K10.38008606
101ACVR1B0.37834309
102BMPR20.37584961
103NTRK10.37165955
104LYN0.36814971
105PRKCD0.36699573
106MAPK40.36677293
107PRKCQ0.36501814
108NEK90.35188323
109EPHA30.35062295
110PRKAA20.34814034
111SGK4940.34663797
112SGK2230.34663797
113ABL10.34375234
114MAP3K50.33783124
115STK30.33582483
116* ITK0.33409274
117TESK20.31528873
118PRKCH0.31466332
119MKNK10.30843558
120* PTK20.30597878
121MAP3K70.29728128
122SYK0.28548821
123MAPK110.27913041
124PDGFRB0.27632567
125PDK10.26553404
126EEF2K0.26458464
127CDC42BPA0.26215171
128NLK0.26178380
129ALK0.25971127
130ROCK10.25960028
131STK110.25919681
132KSR10.25699624
133CDK80.25375411
134LCK0.24958208
135ROCK20.24902360
136PAK60.24452563
137MAP2K40.24296726

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.46670271
2Leishmaniasis_Homo sapiens_hsa051403.34627626
3Leukocyte transendothelial migration_Homo sapiens_hsa046703.27067935
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.29119933
5Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.20829358
6Osteoclast differentiation_Homo sapiens_hsa043802.11133035
7African trypanosomiasis_Homo sapiens_hsa051432.00471279
8Taste transduction_Homo sapiens_hsa047421.93531034
9Bladder cancer_Homo sapiens_hsa052191.93285792
10Shigellosis_Homo sapiens_hsa051311.85137398
11Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.67724130
12Toxoplasmosis_Homo sapiens_hsa051451.65183999
13Chemokine signaling pathway_Homo sapiens_hsa040621.62537031
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.62048188
15VEGF signaling pathway_Homo sapiens_hsa043701.61015658
16TNF signaling pathway_Homo sapiens_hsa046681.53520419
17Tuberculosis_Homo sapiens_hsa051521.50387405
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.50343410
19Adherens junction_Homo sapiens_hsa045201.48126942
20Pancreatic cancer_Homo sapiens_hsa052121.48038407
21Salmonella infection_Homo sapiens_hsa051321.47556086
22Platelet activation_Homo sapiens_hsa046111.45343582
23Histidine metabolism_Homo sapiens_hsa003401.44561957
24Pertussis_Homo sapiens_hsa051331.42202999
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.41859704
26Caffeine metabolism_Homo sapiens_hsa002321.41497704
27B cell receptor signaling pathway_Homo sapiens_hsa046621.38911858
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33114016
29Amoebiasis_Homo sapiens_hsa051461.28491741
30Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.28390946
31Viral myocarditis_Homo sapiens_hsa054161.26732763
32Hepatitis B_Homo sapiens_hsa051611.23137138
33ECM-receptor interaction_Homo sapiens_hsa045121.18807958
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16765228
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.15749851
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.13139729
37Chronic myeloid leukemia_Homo sapiens_hsa052201.12983002
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.12422442
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10770813
40Estrogen signaling pathway_Homo sapiens_hsa049151.10121873
41Legionellosis_Homo sapiens_hsa051341.09484716
42Focal adhesion_Homo sapiens_hsa045101.09045262
43Insulin resistance_Homo sapiens_hsa049311.06950847
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.06674054
45Sphingolipid signaling pathway_Homo sapiens_hsa040711.04679626
46Proteoglycans in cancer_Homo sapiens_hsa052051.02561919
47Serotonergic synapse_Homo sapiens_hsa047261.01568108
48Jak-STAT signaling pathway_Homo sapiens_hsa046301.00595996
49Regulation of actin cytoskeleton_Homo sapiens_hsa048101.00396521
50Malaria_Homo sapiens_hsa051440.97111898
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96950016
52Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96923346
53Hematopoietic cell lineage_Homo sapiens_hsa046400.96589477
54Influenza A_Homo sapiens_hsa051640.94884505
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.92669876
56Acute myeloid leukemia_Homo sapiens_hsa052210.92502195
57Phagosome_Homo sapiens_hsa041450.91593518
58Other glycan degradation_Homo sapiens_hsa005110.89794893
59Dorso-ventral axis formation_Homo sapiens_hsa043200.89669731
60Rap1 signaling pathway_Homo sapiens_hsa040150.85909033
61Renin-angiotensin system_Homo sapiens_hsa046140.83118825
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82751622
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81479557
64Non-small cell lung cancer_Homo sapiens_hsa052230.81224918
65Starch and sucrose metabolism_Homo sapiens_hsa005000.79672225
66Apoptosis_Homo sapiens_hsa042100.79420048
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78774571
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.78640538
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.78568728
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78515914
71Renal cell carcinoma_Homo sapiens_hsa052110.77839285
72Arachidonic acid metabolism_Homo sapiens_hsa005900.76810081
73Hepatitis C_Homo sapiens_hsa051600.76434465
74Ras signaling pathway_Homo sapiens_hsa040140.75443614
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.73705081
76FoxO signaling pathway_Homo sapiens_hsa040680.72057635
77Endocytosis_Homo sapiens_hsa041440.71763759
78Pathways in cancer_Homo sapiens_hsa052000.70440638
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70439157
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70273322
81PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70171828
82Measles_Homo sapiens_hsa051620.69874165
83T cell receptor signaling pathway_Homo sapiens_hsa046600.69654879
84Pentose phosphate pathway_Homo sapiens_hsa000300.68522574
85HIF-1 signaling pathway_Homo sapiens_hsa040660.66847812
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.65732581
87Small cell lung cancer_Homo sapiens_hsa052220.64134966
88ErbB signaling pathway_Homo sapiens_hsa040120.63889485
89MicroRNAs in cancer_Homo sapiens_hsa052060.63120913
90Colorectal cancer_Homo sapiens_hsa052100.62154204
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.60027216
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58909654
93MAPK signaling pathway_Homo sapiens_hsa040100.58374588
94Complement and coagulation cascades_Homo sapiens_hsa046100.56414985
95Choline metabolism in cancer_Homo sapiens_hsa052310.56229178
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55733019
97Ovarian steroidogenesis_Homo sapiens_hsa049130.54667122
98Notch signaling pathway_Homo sapiens_hsa043300.53477289
99mTOR signaling pathway_Homo sapiens_hsa041500.53384881
100Cholinergic synapse_Homo sapiens_hsa047250.52402534
101Prolactin signaling pathway_Homo sapiens_hsa049170.51437816
102GnRH signaling pathway_Homo sapiens_hsa049120.50012313
103Herpes simplex infection_Homo sapiens_hsa051680.49983707
104cAMP signaling pathway_Homo sapiens_hsa040240.49254368
105Asthma_Homo sapiens_hsa053100.47098580
106p53 signaling pathway_Homo sapiens_hsa041150.47005675
107Prostate cancer_Homo sapiens_hsa052150.46703588
108Glutathione metabolism_Homo sapiens_hsa004800.46589616
109Axon guidance_Homo sapiens_hsa043600.46373380
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44758620
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.44649368
112Lysosome_Homo sapiens_hsa041420.44131043
113Long-term depression_Homo sapiens_hsa047300.42552466
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42508870
115Insulin signaling pathway_Homo sapiens_hsa049100.42287133
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41666104
117Ether lipid metabolism_Homo sapiens_hsa005650.41376736
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40455082
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37661972
120TGF-beta signaling pathway_Homo sapiens_hsa043500.36239711
121Glioma_Homo sapiens_hsa052140.35854812

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