BNC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a conserved zinc finger protein. The encoded protein functions in skin color saturation. Mutations in this gene are associated with facial pigmented spots. This gene is also associated with susceptibility to adolescent idiopathic scoliosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1head development (GO:0060322)4.52515167
2regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.49182075
3kinetochore assembly (GO:0051382)4.38886938
4regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.29752055
5kinetochore organization (GO:0051383)4.27484203
6regulation of non-canonical Wnt signaling pathway (GO:2000050)4.26591461
7lymphangiogenesis (GO:0001946)4.21227348
8paraxial mesoderm development (GO:0048339)4.13898728
9replicative senescence (GO:0090399)4.01765056
10anterior/posterior axis specification, embryo (GO:0008595)3.91098204
11G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.89519041
12piRNA metabolic process (GO:0034587)3.84618084
13bone trabecula formation (GO:0060346)3.83686331
14peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.78038226
15cell migration involved in heart development (GO:0060973)3.75881566
16dermatan sulfate biosynthetic process (GO:0030208)3.72835302
17mitotic sister chromatid cohesion (GO:0007064)3.69236792
18planar cell polarity pathway involved in neural tube closure (GO:0090179)3.65445725
19metanephric mesenchyme development (GO:0072075)3.61915351
20DNA methylation involved in gamete generation (GO:0043046)3.58019845
21extracellular regulation of signal transduction (GO:1900115)3.50299624
22extracellular negative regulation of signal transduction (GO:1900116)3.50299624
23protein heterotrimerization (GO:0070208)3.50141620
24mitotic metaphase plate congression (GO:0007080)3.49981860
25regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.44894435
26muscle cell fate commitment (GO:0042693)3.44190489
27response to pheromone (GO:0019236)3.41874220
28outer ear morphogenesis (GO:0042473)3.41241118
29artery development (GO:0060840)3.41227842
30organ induction (GO:0001759)3.37896126
31extracellular fibril organization (GO:0043206)3.33886919
32negative regulation of axon extension involved in axon guidance (GO:0048843)3.33062610
33myoblast migration (GO:0051451)3.32501624
34regulation of nuclear cell cycle DNA replication (GO:0033262)3.32163749
35negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.31694685
36negative regulation of translation, ncRNA-mediated (GO:0040033)3.31694685
37regulation of translation, ncRNA-mediated (GO:0045974)3.31694685
38nuclear pore organization (GO:0006999)3.31492973
39dermatan sulfate metabolic process (GO:0030205)3.30409117
40negative regulation of nitric-oxide synthase activity (GO:0051001)3.29904853
41kidney mesenchyme development (GO:0072074)3.28861713
42glomerular filtration (GO:0003094)3.27558809
43glomerular basement membrane development (GO:0032836)3.27358993
44nuclear pore complex assembly (GO:0051292)3.27050089
45metaphase plate congression (GO:0051310)3.18886621
46pericardium development (GO:0060039)3.18151189
47regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.15296432
48female gonad development (GO:0008585)3.13905598
49positive regulation of catenin import into nucleus (GO:0035413)3.13479340
50regulation of organ formation (GO:0003156)3.13304283
51spindle checkpoint (GO:0031577)3.10291914
52negative regulation of DNA-dependent DNA replication (GO:2000104)3.09583602
53spindle assembly checkpoint (GO:0071173)3.09155910
54negative regulation of keratinocyte proliferation (GO:0010839)3.08977022
55endothelial cell morphogenesis (GO:0001886)3.08502877
56regulation of integrin-mediated signaling pathway (GO:2001044)3.08415944
57extracellular matrix assembly (GO:0085029)3.08175986
58embryonic cranial skeleton morphogenesis (GO:0048701)3.07418686
59mitotic spindle assembly checkpoint (GO:0007094)3.06804940
60retina vasculature morphogenesis in camera-type eye (GO:0061299)3.06353328
61regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.06097895
62fibroblast migration (GO:0010761)3.05539788
63male meiosis (GO:0007140)3.02017023
64negative regulation of mitotic sister chromatid separation (GO:2000816)3.01889920
65negative regulation of mitotic sister chromatid segregation (GO:0033048)3.01889920
66negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.01889920
67negative regulation of sister chromatid segregation (GO:0033046)3.01889920
68substrate adhesion-dependent cell spreading (GO:0034446)3.01761942
69mitotic spindle checkpoint (GO:0071174)3.01737621
70regulation of mitotic metaphase/anaphase transition (GO:0030071)3.00157257
71uterus development (GO:0060065)2.96796549
72negative regulation of chromosome segregation (GO:0051985)2.96645442
73negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.96504020
74regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.96034804
75convergent extension (GO:0060026)2.94441192
76regulation of spindle organization (GO:0090224)2.94352834
77regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.93331649
78regulation of mitotic spindle checkpoint (GO:1903504)2.93331649
79notochord development (GO:0030903)2.93007040
80negative regulation of axon guidance (GO:1902668)2.90837295
81regulation of meiosis I (GO:0060631)2.90607036
82neural crest cell development (GO:0014032)2.89782402
83positive regulation of mesenchymal cell proliferation (GO:0002053)2.89382552
84regulation of mesoderm development (GO:2000380)2.88553072
85neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.88182595
86positive regulation of SMAD protein import into nucleus (GO:0060391)2.88059091
87chromatin remodeling at centromere (GO:0031055)2.88038066
88regulation of mitotic spindle organization (GO:0060236)2.87959737
89chondrocyte development (GO:0002063)2.85852991
90regulation of sister chromatid segregation (GO:0033045)2.85610701
91regulation of mitotic sister chromatid separation (GO:0010965)2.85610701
92regulation of mitotic sister chromatid segregation (GO:0033047)2.85610701
93sequestering of extracellular ligand from receptor (GO:0035581)2.83052573
94regulation of gene silencing by RNA (GO:0060966)2.82384558
95regulation of posttranscriptional gene silencing (GO:0060147)2.82384558
96regulation of gene silencing by miRNA (GO:0060964)2.82384558
97DNA damage induced protein phosphorylation (GO:0006975)2.82363681
98mesenchymal cell development (GO:0014031)2.82279828
99cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.81726355
100chondrocyte proliferation (GO:0035988)2.81644856
101CENP-A containing nucleosome assembly (GO:0034080)2.81617032
102craniofacial suture morphogenesis (GO:0097094)2.80278939
103protein localization to cell surface (GO:0034394)2.79740548
104synaptonemal complex assembly (GO:0007130)2.79044765
105regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.77996441
106regulation of chondrocyte differentiation (GO:0032330)2.77811971
107positive regulation of DNA-dependent DNA replication (GO:2000105)2.75913848
108middle ear morphogenesis (GO:0042474)2.75472949
109collagen fibril organization (GO:0030199)2.74723284
110renal filtration (GO:0097205)2.74649073
111meiotic chromosome segregation (GO:0045132)2.74645540
112negative chemotaxis (GO:0050919)2.74510087
113positive regulation of smoothened signaling pathway (GO:0045880)2.74434347
114smooth muscle tissue development (GO:0048745)2.73548717
115rRNA modification (GO:0000154)2.71770884
116endodermal cell differentiation (GO:0035987)2.70656881
117lateral sprouting from an epithelium (GO:0060601)2.69929282
118establishment of chromosome localization (GO:0051303)2.68692528
119cell migration involved in sprouting angiogenesis (GO:0002042)2.68138927
120face morphogenesis (GO:0060325)2.66698115
121regulation of double-strand break repair via homologous recombination (GO:0010569)2.64978730
122microtubule depolymerization (GO:0007019)2.63996884
123regulation of mesenchymal cell proliferation (GO:0010464)2.63709093
124cell proliferation involved in metanephros development (GO:0072203)2.62362958
125urinary tract smooth muscle contraction (GO:0014848)2.61393905
126negative regulation of androgen receptor signaling pathway (GO:0060766)2.61058746
127negative regulation of BMP signaling pathway (GO:0030514)2.60270909
128histamine secretion (GO:0001821)2.60044568
129neuron projection extension involved in neuron projection guidance (GO:1902284)2.59880475
130axon extension involved in axon guidance (GO:0048846)2.59880475
131hippo signaling (GO:0035329)2.59173363
132attachment of spindle microtubules to kinetochore (GO:0008608)2.58979430
133negative regulation of embryonic development (GO:0045992)2.58534324
134hindbrain development (GO:0030902)2.58456238
135negative regulation of mitosis (GO:0045839)2.58096050
136collagen metabolic process (GO:0032963)2.57964087
137prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.56767872
138negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.56017836
139cranial suture morphogenesis (GO:0060363)2.55941328
140negative regulation of nuclear division (GO:0051784)2.55779427
141embryonic forelimb morphogenesis (GO:0035115)2.55468901
142sister chromatid cohesion (GO:0007062)2.55321530
143regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.54840422
144regulation of double-strand break repair (GO:2000779)2.54612629
145keratan sulfate catabolic process (GO:0042340)2.54404191
146mesenchymal-epithelial cell signaling (GO:0060638)2.53940701
147fibril organization (GO:0097435)2.53852567
148mitotic nuclear envelope disassembly (GO:0007077)2.53851477
149embryonic digit morphogenesis (GO:0042733)2.53644443
150negative regulation of chondrocyte differentiation (GO:0032331)2.53571441
151plasma membrane repair (GO:0001778)2.53438436
152histone H4-K8 acetylation (GO:0043982)2.52979483
153histone H4-K5 acetylation (GO:0043981)2.52979483
154regulation of keratinocyte proliferation (GO:0010837)2.52610162
155regulation of SMAD protein import into nucleus (GO:0060390)2.52478014
156regulation of centriole replication (GO:0046599)2.52339960
157regulation of axon extension involved in axon guidance (GO:0048841)2.52287082
158positive regulation of gastrulation (GO:2000543)2.52109453
159regulation of chromosome segregation (GO:0051983)2.52095511
160membrane assembly (GO:0071709)2.50798377
161cardiac muscle cell development (GO:0055013)2.50400163
162negative regulation of cardiac muscle tissue development (GO:0055026)2.48769498
163forelimb morphogenesis (GO:0035136)2.47963757
164UDP-N-acetylglucosamine metabolic process (GO:0006047)2.47081938
165collagen catabolic process (GO:0030574)2.44562570
166cardiac myofibril assembly (GO:0055003)2.44528710
167negative regulation of protein localization to cell surface (GO:2000009)2.42133231
168negative regulation of cartilage development (GO:0061037)2.40904859
169multicellular organismal macromolecule metabolic process (GO:0044259)2.38583748
170skeletal muscle tissue development (GO:0007519)2.38570730
171lung lobe morphogenesis (GO:0060463)2.38417854
172mammary gland development (GO:0030879)2.38223159
173lung vasculature development (GO:0060426)2.38093761
174* palate development (GO:0060021)2.37873378
175regulation of cartilage development (GO:0061035)2.36721925
176cell fate commitment involved in formation of primary germ layer (GO:0060795)2.36606882
177smooth muscle contraction (GO:0006939)2.36567078
178regulation of cardiac muscle cell differentiation (GO:2000725)2.35801482
179regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.35777712
180positive regulation of cartilage development (GO:0061036)2.35564863

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.26446782
2SALL1_21062744_ChIP-ChIP_HESCs_Human5.33909639
3RBPJ_22232070_ChIP-Seq_NCS_Mouse5.27886929
4TP63_19390658_ChIP-ChIP_HaCaT_Human4.31858229
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.19106016
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.37114153
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.92462211
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.82548660
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.59836790
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.43069097
11CJUN_26792858_Chip-Seq_BT549_Human2.31951632
12POU5F1_16153702_ChIP-ChIP_HESCs_Human2.31780537
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.24236358
14* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.23377278
15HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.10857745
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.04459524
17EP300_21415370_ChIP-Seq_HL-1_Mouse1.99897389
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.98827153
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.96007307
20FUS_26573619_Chip-Seq_HEK293_Human1.93479249
21EWS_26573619_Chip-Seq_HEK293_Human1.89962877
22TAF15_26573619_Chip-Seq_HEK293_Human1.86932336
23VDR_22108803_ChIP-Seq_LS180_Human1.82095710
24NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.81728845
25NRF2_20460467_ChIP-Seq_MEFs_Mouse1.81728845
26* GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79962148
27* SMAD4_21799915_ChIP-Seq_A2780_Human1.79926047
28KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.78535774
29KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.78535774
30KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.78535774
31* TP53_18474530_ChIP-ChIP_U2OS_Human1.77690160
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77655883
33* TP53_16413492_ChIP-PET_HCT116_Human1.76870064
34AR_21909140_ChIP-Seq_LNCAP_Human1.73311464
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.71218091
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.70781479
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67999289
38POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.66902449
39MYC_18555785_ChIP-Seq_MESCs_Mouse1.63848213
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60432523
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.57840135
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.57555787
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.56936983
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56935803
45* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.55745697
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55142739
47ZNF274_21170338_ChIP-Seq_K562_Hela1.54234055
48* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53206933
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49212082
50E2F1_21310950_ChIP-Seq_MCF-7_Human1.48120112
51STAT3_23295773_ChIP-Seq_U87_Human1.47784696
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46699280
53GATA1_26923725_Chip-Seq_HPCs_Mouse1.44622070
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43671025
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40656696
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40321123
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.40211305
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.39043202
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.37414868
60BCAT_22108803_ChIP-Seq_LS180_Human1.34794007
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32917813
62* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32452722
63RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31431488
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29864774
65NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.29127701
66PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.29063300
67SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.25744964
68TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.25442014
69WT1_19549856_ChIP-ChIP_CCG9911_Human1.25164335
70BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24910649
71SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.24126488
72MYC_19079543_ChIP-ChIP_MESCs_Mouse1.22278885
73NANOG_16153702_ChIP-ChIP_HESCs_Human1.21578002
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.20996530
75* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20905087
76* RNF2_27304074_Chip-Seq_NSC_Mouse1.19285379
77FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18828199
78AR_21572438_ChIP-Seq_LNCaP_Human1.18639161
79FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.17970788
80TCF4_18268006_ChIP-ChIP_LS174T_Human1.17501379
81* AR_25329375_ChIP-Seq_VCAP_Human1.16979922
82TCF4_23295773_ChIP-Seq_U87_Human1.15536794
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15379873
84RNF2_18974828_ChIP-Seq_MESCs_Mouse1.15171265
85EZH2_18974828_ChIP-Seq_MESCs_Mouse1.15171265
86AHR_22903824_ChIP-Seq_MCF-7_Human1.15086341
87SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14851149
88ELK1_19687146_ChIP-ChIP_HELA_Human1.14702187
89SOX2_16153702_ChIP-ChIP_HESCs_Human1.14612629
90* KDM2B_26808549_Chip-Seq_REH_Human1.14443443
91CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13190397
92* BRD4_25478319_ChIP-Seq_HGPS_Human1.12923799
93MYC_19030024_ChIP-ChIP_MESCs_Mouse1.11858753
94SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11482842
95NFE2_27457419_Chip-Seq_LIVER_Mouse1.11210601
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11122132
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11080730
98CBP_20019798_ChIP-Seq_JUKART_Human1.10240675
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10240675
100STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09567316
101CRX_20693478_ChIP-Seq_RETINA_Mouse1.08514826
102GBX2_23144817_ChIP-Seq_PC3_Human1.08402035
103CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08140984
104NANOG_18555785_Chip-Seq_ESCs_Mouse1.08036487
105SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.07953226
106SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.07915664
107EZH2_27304074_Chip-Seq_ESCs_Mouse1.07595425
108TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07289384
109SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.06679453
110CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06002722
111GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05658088
112NELFA_20434984_ChIP-Seq_ESCs_Mouse1.05573574
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05314259
114TCF3_18692474_ChIP-Seq_MESCs_Mouse1.05164318
115SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05117973
116* RUNX2_22187159_ChIP-Seq_PCA_Human1.04363281
117* SOX2_21211035_ChIP-Seq_LN229_Gbm1.03017927
118PIAS1_25552417_ChIP-Seq_VCAP_Human1.02263274
119* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01601052
120SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.01419077
121SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00410555
122E2F1_18555785_Chip-Seq_ESCs_Mouse0.99018766
123EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98067478
124SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.97403634
125PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96757036
126PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95253881
127CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.95069898
128* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94854860
129EST1_17652178_ChIP-ChIP_JURKAT_Human0.94572282
130* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93216154
131MYCN_18555785_ChIP-Seq_MESCs_Mouse0.93142293
132* P300_19829295_ChIP-Seq_ESCs_Human0.92265258
133PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.91555231
134TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91212401
135POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91212401
136HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.91029437
137CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90874304
138ISL1_27105846_Chip-Seq_CPCs_Mouse0.90198050
139POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.90065801
140* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89585373
141TBX3_20139965_ChIP-Seq_ESCs_Mouse0.87342811
142NANOG_21062744_ChIP-ChIP_HESCs_Human0.86719499
143KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.86308564
144ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.85897848
145TBX3_20139965_ChIP-Seq_MESCs_Mouse0.85596620
146POU5F1_16518401_ChIP-PET_MESCs_Mouse0.85345024
147TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.84340584
148NOTCH1_21737748_ChIP-Seq_TLL_Human0.84233123
149TCF3_18692474_ChIP-Seq_MEFs_Mouse0.84033422
150EZH2_22144423_ChIP-Seq_EOC_Human0.83881559
151KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.83480714
152CTBP2_25329375_ChIP-Seq_LNCAP_Human0.83418273
153GABP_17652178_ChIP-ChIP_JURKAT_Human0.82981280
154PCGF2_27294783_Chip-Seq_NPCs_Mouse0.81453215
155EZH2_27294783_Chip-Seq_NPCs_Mouse0.81256141

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology4.12214969
2MP0000566_synostosis3.62101200
3MP0003950_abnormal_plasma_membrane3.51560223
4MP0005171_absent_coat_pigmentation2.90241387
5MP0010030_abnormal_orbit_morphology2.88518599
6MP0003122_maternal_imprinting2.84575745
7MP0003121_genomic_imprinting2.73861156
8MP0004272_abnormal_basement_membrane2.68734563
9MP0008438_abnormal_cutaneous_collagen2.67420877
10MP0003941_abnormal_skin_development2.52286608
11MP0005275_abnormal_skin_tensile2.39984922
12MP0010368_abnormal_lymphatic_system2.39196077
13MP0002938_white_spotting2.39098967
14MP0009780_abnormal_chondrocyte_physiolo2.32064484
15MP0006054_spinal_hemorrhage2.27828795
16MP0008877_abnormal_DNA_methylation2.26117287
17MP0002249_abnormal_larynx_morphology2.13358699
18MP0003937_abnormal_limbs/digits/tail_de2.11657013
19MP0009250_abnormal_appendicular_skeleto2.08878869
20MP0003385_abnormal_body_wall2.07028423
21MP0001958_emphysema2.06884797
22MP0003123_paternal_imprinting2.04279229
23MP0000049_abnormal_middle_ear1.96694691
24MP0003111_abnormal_nucleus_morphology1.96518539
25MP0005257_abnormal_intraocular_pressure1.95498550
26MP0000749_muscle_degeneration1.94767851
27MP0010094_abnormal_chromosome_stability1.92894212
28MP0000372_irregular_coat_pigmentation1.90766335
29* MP0003755_abnormal_palate_morphology1.90731987
30MP0003693_abnormal_embryo_hatching1.88516728
31MP0001293_anophthalmia1.68711392
32* MP0000762_abnormal_tongue_morphology1.68566588
33MP0001986_abnormal_taste_sensitivity1.68209218
34MP0005508_abnormal_skeleton_morphology1.67922687
35MP0001542_abnormal_bone_strength1.67021080
36MP0000751_myopathy1.64944364
37MP0003942_abnormal_urinary_system1.64583249
38MP0006292_abnormal_olfactory_placode1.58976945
39MP0008057_abnormal_DNA_replication1.58602913
40MP0005623_abnormal_meninges_morphology1.55614686
41MP0000534_abnormal_ureter_morphology1.54277456
42MP0000767_abnormal_smooth_muscle1.52980403
43MP0002233_abnormal_nose_morphology1.52886204
44* MP0003935_abnormal_craniofacial_develop1.49861491
45MP0003136_yellow_coat_color1.46052291
46MP0003077_abnormal_cell_cycle1.45906838
47MP0000613_abnormal_salivary_gland1.44932639
48MP0010386_abnormal_urinary_bladder1.42401302
49MP0009697_abnormal_copulation1.41820674
50MP0004084_abnormal_cardiac_muscle1.40293921
51MP0002109_abnormal_limb_morphology1.39397936
52MP0002102_abnormal_ear_morphology1.39294878
53* MP0000432_abnormal_head_morphology1.38792379
54MP0002932_abnormal_joint_morphology1.35853361
55MP0002234_abnormal_pharynx_morphology1.35464413
56MP0000428_abnormal_craniofacial_morphol1.33641077
57MP0009053_abnormal_anal_canal1.33485256
58MP0005595_abnormal_vascular_smooth1.33302040
59* MP0002116_abnormal_craniofacial_bone1.33240042
60MP0001346_abnormal_lacrimal_gland1.30677345
61MP0008007_abnormal_cellular_replicative1.30135980
62MP0002295_abnormal_pulmonary_circulatio1.28857222
63MP0008058_abnormal_DNA_repair1.28843847
64MP0008932_abnormal_embryonic_tissue1.24424255
65MP0002108_abnormal_muscle_morphology1.23514935
66MP0004957_abnormal_blastocyst_morpholog1.22860917
67MP0005023_abnormal_wound_healing1.20417858
68MP0004145_abnormal_muscle_electrophysio1.19749003
69MP0002163_abnormal_gland_morphology1.19397096
70MP0003787_abnormal_imprinting1.19197170
71MP0003566_abnormal_cell_adhesion1.15852302
72MP0001286_abnormal_eye_development1.15096888
73MP0003283_abnormal_digestive_organ1.14735064
74MP0004036_abnormal_muscle_relaxation1.14243489
75MP0000579_abnormal_nail_morphology1.13237142
76MP0000516_abnormal_urinary_system1.13078312
77MP0005367_renal/urinary_system_phenotyp1.13078312
78MP0002210_abnormal_sex_determination1.12818200
79MP0009384_cardiac_valve_regurgitation1.12599300
80MP0000678_abnormal_parathyroid_gland1.11952879
81MP0003938_abnormal_ear_development1.10701409
82MP0000569_abnormal_digit_pigmentation1.10663905
83MP0000013_abnormal_adipose_tissue1.09924430
84MP0002177_abnormal_outer_ear1.09162744
85MP0005187_abnormal_penis_morphology1.09089819
86MP0003718_maternal_effect1.07430459
87* MP0002085_abnormal_embryonic_tissue1.07015769
88MP0000163_abnormal_cartilage_morphology1.06339189
89MP0000538_abnormal_urinary_bladder1.06338039
90MP0001270_distended_abdomen1.06209248
91MP0005248_abnormal_Harderian_gland1.06124369
92MP0000733_abnormal_muscle_development1.05998211
93MP0002282_abnormal_trachea_morphology1.04951294
94MP0005369_muscle_phenotype1.03168100
95MP0002111_abnormal_tail_morphology1.02867810
96MP0003890_abnormal_embryonic-extraembry1.02714502
97MP0002114_abnormal_axial_skeleton1.00426921
98MP0001879_abnormal_lymphatic_vessel1.00417360
99MP0002115_abnormal_skeleton_extremities0.99700532
100MP0003567_abnormal_fetal_cardiomyocyte0.99676936
101MP0005620_abnormal_muscle_contractility0.98919363
102MP0001243_abnormal_dermal_layer0.97889455
103MP0003786_premature_aging0.96139308
104MP0001119_abnormal_female_reproductive0.95542238
105MP0002896_abnormal_bone_mineralization0.95468355
106MP0000750_abnormal_muscle_regeneration0.95241888
107MP0000462_abnormal_digestive_system0.93972189
108MP0003279_aneurysm0.92430054
109* MP0002113_abnormal_skeleton_development0.91516431
110MP0002084_abnormal_developmental_patter0.90878520
111MP0000383_abnormal_hair_follicle0.90697848
112* MP0009703_decreased_birth_body0.90155254
113MP0005408_hypopigmentation0.89763868
114MP0008789_abnormal_olfactory_epithelium0.89707221
115MP0001188_hyperpigmentation0.89635951
116MP0004134_abnormal_chest_morphology0.88440224
117MP0005395_other_phenotype0.88261398
118MP0005377_hearing/vestibular/ear_phenot0.87404973
119MP0003878_abnormal_ear_physiology0.87404973
120MP0000759_abnormal_skeletal_muscle0.85414348
121MP0000653_abnormal_sex_gland0.83804213
122MP0005423_abnormal_somatic_nervous0.83698526
123MP0001299_abnormal_eye_distance/0.83101194
124MP0003091_abnormal_cell_migration0.82745559
125MP0002254_reproductive_system_inflammat0.82402301
126MP0002168_other_aberrant_phenotype0.82252720
127MP0000427_abnormal_hair_cycle0.81690296
128MP0000350_abnormal_cell_proliferation0.81602224
129MP0002060_abnormal_skin_morphology0.81144818
130MP0002075_abnormal_coat/hair_pigmentati0.80765716
131MP0001145_abnormal_male_reproductive0.80278382
132MP0004197_abnormal_fetal_growth/weight/0.79790137
133MP0005390_skeleton_phenotype0.79589397
134MP0003115_abnormal_respiratory_system0.79074232
135MP0002095_abnormal_skin_pigmentation0.79056215
136MP0003705_abnormal_hypodermis_morpholog0.78558169
137MP0010352_gastrointestinal_tract_polyps0.78355702
138MP0004087_abnormal_muscle_fiber0.76983664
139MP0008775_abnormal_heart_ventricle0.74654043
140MP0002128_abnormal_blood_circulation0.74297755
141MP0002106_abnormal_muscle_physiology0.71980132
142MP0002160_abnormal_reproductive_system0.71957177
143MP0002269_muscular_atrophy0.70317566
144MP0001661_extended_life_span0.68265419
145MP0004133_heterotaxia0.66267818
146MP0003959_abnormal_lean_body0.65279939
147MP0004233_abnormal_muscle_weight0.63937204
148MP0005197_abnormal_uvea_morphology0.63430750
149MP0005174_abnormal_tail_pigmentation0.62351638
150MP0003119_abnormal_digestive_system0.62293174
151MP0003868_abnormal_feces_composition0.61752808
152MP0002133_abnormal_respiratory_system0.61294505
153MP0005388_respiratory_system_phenotype0.61294505

Predicted human phenotypes

RankGene SetZ-score
1Aortic dissection (HP:0002647)5.68526907
2Aortic aneurysm (HP:0004942)5.56348057
3Short 4th metacarpal (HP:0010044)4.59491578
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.59491578
5Duplicated collecting system (HP:0000081)4.27823288
6Abnormality of the renal collecting system (HP:0004742)4.07764628
7Type 1 muscle fiber predominance (HP:0003803)3.75239119
8Vascular tortuosity (HP:0004948)3.72412361
9Broad metatarsal (HP:0001783)3.60137105
10Microglossia (HP:0000171)3.38737582
11Arterial tortuosity (HP:0005116)3.25436922
12Chromsome breakage (HP:0040012)3.23654460
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.21056259
14Abnormality of the 4th metacarpal (HP:0010012)3.12313039
15Spondylolisthesis (HP:0003302)3.10944627
16Increased number of teeth (HP:0011069)3.07804732
17Nemaline bodies (HP:0003798)3.06807071
18Pulmonary artery stenosis (HP:0004415)3.03251811
19Bladder diverticulum (HP:0000015)2.96444340
20Absent frontal sinuses (HP:0002688)2.93883402
21Coronal craniosynostosis (HP:0004440)2.87632250
22Mitral valve prolapse (HP:0001634)2.80808359
23Neonatal short-limb short stature (HP:0008921)2.76169688
24Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.75223774
25Abnormality of dentin (HP:0010299)2.73410238
26Atrophic scars (HP:0001075)2.68173983
27Supernumerary ribs (HP:0005815)2.67847392
28Absent eyebrow (HP:0002223)2.64727430
29Abnormality of the parietal bone (HP:0002696)2.63005445
30Long foot (HP:0001833)2.60445204
31Hypoplastic ischia (HP:0003175)2.58968765
32Wormian bones (HP:0002645)2.58708264
33Lip pit (HP:0100267)2.58692848
34Keratoconus (HP:0000563)2.58434328
35Increased corneal curvature (HP:0100692)2.58434328
36Abnormality of the labia minora (HP:0012880)2.57430932
37Muscle fiber inclusion bodies (HP:0100299)2.55670974
38Breast hypoplasia (HP:0003187)2.54124162
39Supernumerary bones of the axial skeleton (HP:0009144)2.53389475
40Abnormality of the ischium (HP:0003174)2.51061186
41Follicular hyperkeratosis (HP:0007502)2.50615124
42Aortic regurgitation (HP:0001659)2.49995626
43Shallow orbits (HP:0000586)2.49334377
44Genu recurvatum (HP:0002816)2.47204666
45Cutaneous finger syndactyly (HP:0010554)2.46980655
46Midline defect of the nose (HP:0004122)2.45817158
47Acute lymphatic leukemia (HP:0006721)2.44517316
48Spinal rigidity (HP:0003306)2.41733809
49Ectopic kidney (HP:0000086)2.38227339
50Protrusio acetabuli (HP:0003179)2.37065680
51Meckel diverticulum (HP:0002245)2.35869051
52Abnormality of the nasal septum (HP:0000419)2.34589610
53Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.32910773
54Hypoplastic nipples (HP:0002557)2.28915266
55Slender build (HP:0001533)2.25780610
56Hyperextensible skin (HP:0000974)2.25366989
57Osteolytic defects of the hand bones (HP:0009699)2.25141520
58Osteolytic defects of the phalanges of the hand (HP:0009771)2.25141520
59Cervical subluxation (HP:0003308)2.21928306
60Abnormality of the ileum (HP:0001549)2.20703610
61Dilatation of the ascending aorta (HP:0005111)2.20646724
62Abnormality of the phalanges of the hallux (HP:0010057)2.19062776
63Cerebral aneurysm (HP:0004944)2.18987633
64Adrenal hypoplasia (HP:0000835)2.18660901
65Aplasia of the musculature (HP:0100854)2.18463128
66Blue sclerae (HP:0000592)2.18370675
67Cutaneous syndactyly (HP:0012725)2.18230523
68Infantile muscular hypotonia (HP:0008947)2.15486319
69Abnormality of abdominal situs (HP:0011620)2.15080176
70Abdominal situs inversus (HP:0003363)2.15080176
71Hip contracture (HP:0003273)2.14638008
72Overgrowth (HP:0001548)2.14081322
73Bowel diverticulosis (HP:0005222)2.10808260
74Soft skin (HP:0000977)2.10766513
75Abnormality of incisor morphology (HP:0011063)2.10508179
76Absent phalangeal crease (HP:0006109)2.10032713
77Round ear (HP:0100830)2.08862476
78Trigonocephaly (HP:0000243)2.08255583
79Congenital sensorineural hearing impairment (HP:0008527)2.08046687
80Abnormality of the frontal sinuses (HP:0002687)2.05694812
81Premature rupture of membranes (HP:0001788)2.04959486
82Ankle contracture (HP:0006466)2.04628028
83Peritonitis (HP:0002586)2.04394171
84Birth length less than 3rd percentile (HP:0003561)2.03725655
85Oligodontia (HP:0000677)2.01417715
86Short middle phalanx of the 5th finger (HP:0004220)2.01344026
87Gonadotropin excess (HP:0000837)2.00611493
88Hypoplasia of the maxilla (HP:0000327)1.99863380
89Long eyelashes (HP:0000527)1.98912989
90Clubbing of toes (HP:0100760)1.97553627
91Fragile skin (HP:0001030)1.97149785
92Ureteral duplication (HP:0000073)1.96622141
93Wide cranial sutures (HP:0010537)1.96062605
94Ulnar bowing (HP:0003031)1.95575175
95Facial cleft (HP:0002006)1.95362696
96Narrow palate (HP:0000189)1.94085937
97Nephroblastoma (Wilms tumor) (HP:0002667)1.93980471
98Mesomelia (HP:0003027)1.93953003
99Type 2 muscle fiber atrophy (HP:0003554)1.93274706
100Abnormality of the incisor (HP:0000676)1.92640199
101Atresia of the external auditory canal (HP:0000413)1.91540323
102Popliteal pterygium (HP:0009756)1.91347650
103Embryonal renal neoplasm (HP:0011794)1.91343726
104Shawl scrotum (HP:0000049)1.91217448
105Joint laxity (HP:0001388)1.91009036
106Abnormal number of incisors (HP:0011064)1.90682336
107Biconcave vertebral bodies (HP:0004586)1.88000487
108Aplasia/Hypoplasia of the uvula (HP:0010293)1.87958734
109Patellar aplasia (HP:0006443)1.86586985
110White forelock (HP:0002211)1.86171143
111Breech presentation (HP:0001623)1.85384812
112Aortic valve stenosis (HP:0001650)1.84696329
113Distal arthrogryposis (HP:0005684)1.84148051
114Persistence of primary teeth (HP:0006335)1.83853231
115Abnormal finger flexion creases (HP:0006143)1.83525060
116Aplasia/Hypoplasia of the tongue (HP:0010295)1.83335049
117Dislocated radial head (HP:0003083)1.81762688
118Morphological abnormality of the middle ear (HP:0008609)1.81672024
119Broad toe (HP:0001837)1.81041798
120Selective tooth agenesis (HP:0001592)1.80887332
121Abnormality of the nasolacrimal system (HP:0000614)1.80393631
122Tracheomalacia (HP:0002779)1.80338144
123Abnormality of the radial head (HP:0003995)1.79658610
124Abnormality of the acetabulum (HP:0003170)1.78485952
125Knee flexion contracture (HP:0006380)1.78415905
126Spinal cord lesions (HP:0100561)1.78400224
127Syringomyelia (HP:0003396)1.78400224
128Delayed cranial suture closure (HP:0000270)1.77896592
129Papillary thyroid carcinoma (HP:0002895)1.77758115
130Neoplasm of the adrenal cortex (HP:0100641)1.77486826
131Decreased muscle mass (HP:0003199)1.77439452
132Delayed closure of the anterior fontanelle (HP:0001476)1.77186766
133Depressed nasal tip (HP:0000437)1.76630726
134Bell-shaped thorax (HP:0001591)1.76518910
135Delayed gross motor development (HP:0002194)1.76082284
136Aplasia/Hypoplasia of the patella (HP:0006498)1.75991072
137Abnormality of chromosome stability (HP:0003220)1.75600908
138Short clavicles (HP:0000894)1.74880047
139Wrist flexion contracture (HP:0001239)1.74537983
140Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.74515474
141Convex nasal ridge (HP:0000444)1.74176830
142Hypoplastic labia majora (HP:0000059)1.72858041
143Aneurysm (HP:0002617)1.72780798
144Calcaneovalgus deformity (HP:0001848)1.72486720
145Abnormality of the lacrimal duct (HP:0011481)1.72303819
146Limited hip movement (HP:0008800)1.72072402
147Renal duplication (HP:0000075)1.71550020
148Conical tooth (HP:0000698)1.71504232
149Nasolacrimal duct obstruction (HP:0000579)1.70178078
150Aplasia/Hypoplasia of the sternum (HP:0006714)1.70176152
151Adactyly (HP:0009776)1.70162759
152Abnormality of the calf musculature (HP:0001430)1.69958590
153Abnormality of the phalanges of the 2nd finger (HP:0009541)1.69818702
154Broad ribs (HP:0000885)1.69766726
155Deformed tarsal bones (HP:0008119)1.69762379
156Ectopia lentis (HP:0001083)1.69478780
157Abnormality of the middle phalanges of the toes (HP:0010183)1.69071073
158Facial hemangioma (HP:0000329)1.68393435
159Patchy hypopigmentation of hair (HP:0011365)1.68036451
160Camptodactyly of toe (HP:0001836)1.67557110
161Renal hypoplasia (HP:0000089)1.67123903
162Pulmonic stenosis (HP:0001642)1.66215782
163Fatigable weakness (HP:0003473)1.65656032
164Abnormality of the neuromuscular junction (HP:0003398)1.65656032
165Increased nuchal translucency (HP:0010880)1.65119587
166Broad thumb (HP:0011304)1.65011856
167Elbow flexion contracture (HP:0002987)1.64864217
168Wide anterior fontanel (HP:0000260)1.64658025
169Long clavicles (HP:0000890)1.64548878
170Hypoplastic scapulae (HP:0000882)1.63962478
171Aplasia/Hypoplasia of the scapulae (HP:0006713)1.63962478
172Prostate neoplasm (HP:0100787)1.63011699
173Broad long bones (HP:0005622)1.61168757
174Supernumerary spleens (HP:0009799)1.61003277
175Duodenal stenosis (HP:0100867)1.60765212
176Small intestinal stenosis (HP:0012848)1.60765212
177Hepatoblastoma (HP:0002884)1.60302303
178Abnormality of the fingertips (HP:0001211)1.59268644
179Oligodactyly (HP:0012165)1.59015525

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK4.23552062
2LATS14.13115369
3EPHA33.97395741
4MUSK3.57488896
5INSRR3.56905927
6MYLK3.47991513
7CDK123.41225840
8STK38L2.99432096
9PLK42.89822161
10CDC72.70664214
11TTK2.68187981
12AKT32.60053558
13LATS22.23929275
14BRD42.17898794
15TGFBR22.12234831
16PNCK1.99502532
17LIMK11.96515076
18IRAK31.96418672
19CHEK21.91002644
20ACVR1B1.89664365
21OBSCN1.86066971
22PIK3CG1.86013351
23PLK31.79909652
24CDK81.77971004
25DDR21.74030829
26PAK21.70462877
27STK31.67669702
28ATR1.67195479
29BUB11.65760037
30TGFBR11.60270638
31TTN1.60097084
32CDC42BPA1.58962406
33WEE11.53413352
34PLK11.52172343
35SRPK11.48993000
36NUAK11.46070779
37EPHA21.45409729
38TNIK1.41048719
39TIE11.36940183
40CDK71.35168882
41ADRBK21.32445373
42FGFR21.30196859
43CAMK1D1.28694383
44PTK21.26392794
45DMPK1.25817254
46MAP4K21.25525590
47EIF2AK21.24695506
48TAF11.18590222
49GRK11.17899008
50PDGFRB1.16681886
51BMPR1B1.16048503
52EIF2AK11.13366464
53MKNK21.13067644
54FER1.12394670
55VRK11.12277055
56NEK21.12125385
57CDK31.09670872
58MST1R1.09550441
59ATM1.08834644
60EPHB21.08107557
61PRKCE1.07687363
62BRAF1.04787447
63MKNK11.01973880
64FRK1.00264824
65CHEK10.99869004
66EIF2AK30.99807103
67AURKB0.97011912
68SIK30.96208619
69CDK90.96050208
70PLK20.95662115
71PAK30.94689572
72NEK60.93543301
73PTK2B0.93203223
74RPS6KA40.92310976
75MET0.91826706
76BRSK20.87494777
77ERBB30.83243219
78MELK0.81623241
79DYRK20.81597911
80SIK10.80817752
81IRAK10.80032453
82TRIM280.78332440
83ERBB40.77898806
84ADRBK10.77727922
85MTOR0.77120351
86MAPKAPK50.77069747
87MAPK130.76458335
88GSK3A0.75189883
89PDGFRA0.69729559
90SGK20.68789156
91MAP3K60.68425097
92WNK30.68051131
93CDK10.68011158
94STK160.66414908
95TSSK60.65646770
96STK380.64065068
97MARK10.63643969
98NEK90.63294079
99CDK20.63144581
100RPS6KB20.60181741
101MARK30.59672942
102IRAK20.58775713
103STK390.58510809
104PIK3CA0.57634689
105CHUK0.56274494
106FGFR10.53436468
107ROCK10.51393263
108NLK0.50445293
109VRK20.49642083
110GRK70.49072324
111BCR0.48578280
112TRPM70.47217224
113GRK50.45598395
114WNK10.44789068
115MAP2K10.44609565
116CAMK1G0.44473084
117CASK0.44032896
118MAPK140.43399016
119PBK0.43390114
120PRKCI0.43168160
121MAPK70.41501042
122CSNK1A1L0.41263140
123RPS6KA20.40881543
124OXSR10.40476763
125AKT10.40425917
126CAMK2G0.40397746
127ABL20.39963692
128DYRK30.39325533
129GSK3B0.39299265
130IRAK40.39258990
131FLT30.38918096
132PRKD20.38796723
133CSNK1G10.38432242
134CAMK2D0.38067441
135MAPK10.37836605
136NEK10.37725691
137PRKAA20.37469941
138STK40.36877498
139AURKA0.36369725
140CSNK2A10.36265828
141CSNK1E0.35642339
142PAK40.34460128
143CAMK2A0.33864484
144ROCK20.32988593
145SGK2230.32432495
146SGK4940.32432495
147BRSK10.31656735
148PRKD10.31367671
149MAPK80.30976314
150KSR10.30647308
151SGK30.29193081
152CSNK1D0.28989707

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.56562599
2Cell cycle_Homo sapiens_hsa041103.24171369
3RNA polymerase_Homo sapiens_hsa030202.95702927
4Basal transcription factors_Homo sapiens_hsa030222.95260909
5Homologous recombination_Homo sapiens_hsa034402.89081269
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.83589263
7Mismatch repair_Homo sapiens_hsa034302.70287772
8DNA replication_Homo sapiens_hsa030302.48441215
9Dilated cardiomyopathy_Homo sapiens_hsa054142.47363360
10RNA transport_Homo sapiens_hsa030132.36563963
11Basal cell carcinoma_Homo sapiens_hsa052172.25967131
12Nucleotide excision repair_Homo sapiens_hsa034202.17646910
13p53 signaling pathway_Homo sapiens_hsa041152.09425835
14RNA degradation_Homo sapiens_hsa030182.02262494
15Spliceosome_Homo sapiens_hsa030401.87052053
16Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.85763567
17TGF-beta signaling pathway_Homo sapiens_hsa043501.83509368
18Pyrimidine metabolism_Homo sapiens_hsa002401.82302683
19Hedgehog signaling pathway_Homo sapiens_hsa043401.80850439
20Renin-angiotensin system_Homo sapiens_hsa046141.78778469
21Vascular smooth muscle contraction_Homo sapiens_hsa042701.78370256
22Base excision repair_Homo sapiens_hsa034101.75410554
23Adherens junction_Homo sapiens_hsa045201.70794576
24Hippo signaling pathway_Homo sapiens_hsa043901.57779955
25MicroRNAs in cancer_Homo sapiens_hsa052061.54819778
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.52414667
27Non-homologous end-joining_Homo sapiens_hsa034501.51532016
28Protein export_Homo sapiens_hsa030601.45981263
29Selenocompound metabolism_Homo sapiens_hsa004501.45362650
30mRNA surveillance pathway_Homo sapiens_hsa030151.43698908
31One carbon pool by folate_Homo sapiens_hsa006701.39284340
32Wnt signaling pathway_Homo sapiens_hsa043101.37967229
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.36993717
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36720520
35ECM-receptor interaction_Homo sapiens_hsa045121.34914955
36Taste transduction_Homo sapiens_hsa047421.31622846
37Calcium signaling pathway_Homo sapiens_hsa040201.27815008
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.24730006
39Prostate cancer_Homo sapiens_hsa052151.17230486
40Proteasome_Homo sapiens_hsa030501.17014968
41Purine metabolism_Homo sapiens_hsa002301.15541990
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.15174202
43Propanoate metabolism_Homo sapiens_hsa006401.14657647
44Ribosome_Homo sapiens_hsa030101.13607555
45Epstein-Barr virus infection_Homo sapiens_hsa051691.12917382
46Amoebiasis_Homo sapiens_hsa051461.11903969
47Melanoma_Homo sapiens_hsa052181.10888653
48Notch signaling pathway_Homo sapiens_hsa043301.10865704
49HTLV-I infection_Homo sapiens_hsa051661.09182383
50Transcriptional misregulation in cancer_Homo sapiens_hsa052021.06712213
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02807413
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.02411196
53Small cell lung cancer_Homo sapiens_hsa052221.00881821
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.00583323
55Oocyte meiosis_Homo sapiens_hsa041141.00424784
56Protein digestion and absorption_Homo sapiens_hsa049741.00375170
57Herpes simplex infection_Homo sapiens_hsa051680.98497503
58Pathways in cancer_Homo sapiens_hsa052000.96904790
59Lysine degradation_Homo sapiens_hsa003100.92629986
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85565842
61Axon guidance_Homo sapiens_hsa043600.85452834
62Gap junction_Homo sapiens_hsa045400.84833735
63Viral carcinogenesis_Homo sapiens_hsa052030.83860384
64Phototransduction_Homo sapiens_hsa047440.78362991
65Systemic lupus erythematosus_Homo sapiens_hsa053220.78299909
66Colorectal cancer_Homo sapiens_hsa052100.77718694
67FoxO signaling pathway_Homo sapiens_hsa040680.74963498
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70585761
69Proteoglycans in cancer_Homo sapiens_hsa052050.70237774
70PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70203507
71Melanogenesis_Homo sapiens_hsa049160.69550330
72Serotonergic synapse_Homo sapiens_hsa047260.68028713
73Ether lipid metabolism_Homo sapiens_hsa005650.67501079
74Ovarian steroidogenesis_Homo sapiens_hsa049130.66608815
75Oxytocin signaling pathway_Homo sapiens_hsa049210.66263947
76Focal adhesion_Homo sapiens_hsa045100.65740503
77Linoleic acid metabolism_Homo sapiens_hsa005910.64360642
78Renin secretion_Homo sapiens_hsa049240.63992611
79Nicotine addiction_Homo sapiens_hsa050330.63778705
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62426165
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61931397
82MAPK signaling pathway_Homo sapiens_hsa040100.60613428
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.60087467
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59746954
85Pancreatic cancer_Homo sapiens_hsa052120.58296476
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57967664
87Thyroid cancer_Homo sapiens_hsa052160.57865168
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.56866977
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54547397
90ABC transporters_Homo sapiens_hsa020100.53559610
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52605476
92Hepatitis B_Homo sapiens_hsa051610.51748617
93Complement and coagulation cascades_Homo sapiens_hsa046100.50873631
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.50841720
95Endometrial cancer_Homo sapiens_hsa052130.49392305
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47338412
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47211675
98Circadian rhythm_Homo sapiens_hsa047100.46968274
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46886028
100cAMP signaling pathway_Homo sapiens_hsa040240.44721384
101Tryptophan metabolism_Homo sapiens_hsa003800.44363192
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44094707
103Vitamin B6 metabolism_Homo sapiens_hsa007500.43817368
104Thyroid hormone synthesis_Homo sapiens_hsa049180.43031804
105Insulin secretion_Homo sapiens_hsa049110.42933327
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42918552
107Circadian entrainment_Homo sapiens_hsa047130.42748246
108Arachidonic acid metabolism_Homo sapiens_hsa005900.42506883
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42441915
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42112195
111Salivary secretion_Homo sapiens_hsa049700.41981216
112Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41931978
113Retinol metabolism_Homo sapiens_hsa008300.41592172
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40480981
115Cocaine addiction_Homo sapiens_hsa050300.40263792
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40255893
117Malaria_Homo sapiens_hsa051440.39820938
118NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38110441
119Mineral absorption_Homo sapiens_hsa049780.37648633
120Tight junction_Homo sapiens_hsa045300.37278834
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.37024000
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36366149
123Platelet activation_Homo sapiens_hsa046110.36230883
124Glutamatergic synapse_Homo sapiens_hsa047240.36025227
125TNF signaling pathway_Homo sapiens_hsa046680.35689949
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35296768
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35254696
128Chronic myeloid leukemia_Homo sapiens_hsa052200.33458486
129Ras signaling pathway_Homo sapiens_hsa040140.32841678
130Cardiac muscle contraction_Homo sapiens_hsa042600.31629292
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29387876
132Bladder cancer_Homo sapiens_hsa052190.27493869
133Rap1 signaling pathway_Homo sapiens_hsa040150.27163083
134Alcoholism_Homo sapiens_hsa050340.26960283
135Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26177448
136Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25801111
137Dorso-ventral axis formation_Homo sapiens_hsa043200.23054669
138mTOR signaling pathway_Homo sapiens_hsa041500.22991909
139Influenza A_Homo sapiens_hsa051640.22028530
140Choline metabolism in cancer_Homo sapiens_hsa052310.21578750
141Hematopoietic cell lineage_Homo sapiens_hsa046400.19846700
142Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19581098
143Graft-versus-host disease_Homo sapiens_hsa053320.19224170
144Renal cell carcinoma_Homo sapiens_hsa052110.18670873

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »