BNIP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. In addition, this protein is involved in vesicle transport into the endoplasmic reticulum. Alternative splicing of this gene results in four protein products with identical N- and C-termini. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial calcium ion transport (GO:0006851)7.61722974
2regulation of cholesterol esterification (GO:0010872)7.60260251
3erythrocyte maturation (GO:0043249)6.93599131
4mitochondrial calcium ion homeostasis (GO:0051560)5.57342952
5hematopoietic stem cell differentiation (GO:0060218)5.36960381
67-methylguanosine mRNA capping (GO:0006370)5.22935161
7termination of RNA polymerase I transcription (GO:0006363)5.11574695
87-methylguanosine RNA capping (GO:0009452)5.10389492
9RNA capping (GO:0036260)5.10389492
10UV protection (GO:0009650)5.03099019
11DNA excision (GO:0044349)4.89118681
12nucleotide-excision repair, DNA damage removal (GO:0000718)4.89118681
13transcription-coupled nucleotide-excision repair (GO:0006283)4.75605377
14telomere maintenance via semi-conservative replication (GO:0032201)4.67479250
15spinal cord development (GO:0021510)4.60680494
16DNA deamination (GO:0045006)4.54972974
17myelin assembly (GO:0032288)4.50804973
18ribosomal small subunit assembly (GO:0000028)4.49054422
19anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.39773538
20transcription elongation from RNA polymerase I promoter (GO:0006362)4.31806183
21cullin deneddylation (GO:0010388)4.24213045
22deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.18420918
23protein deneddylation (GO:0000338)4.14724522
24regulation of cellular amino acid metabolic process (GO:0006521)4.14688421
25telomere maintenance via recombination (GO:0000722)4.10481899
26DNA damage response, detection of DNA damage (GO:0042769)4.08503944
27DNA strand elongation involved in DNA replication (GO:0006271)4.08113141
28signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.00459424
29intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.00459424
30establishment of protein localization to mitochondrial membrane (GO:0090151)3.98959257
31DNA strand elongation (GO:0022616)3.98548369
32lysosome localization (GO:0032418)3.93053280
33chaperone-mediated protein transport (GO:0072321)3.92453579
34positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.91427446
35mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.89530819
36signal transduction involved in DNA integrity checkpoint (GO:0072401)3.88699625
37signal transduction involved in DNA damage checkpoint (GO:0072422)3.88699625
38signal transduction involved in cell cycle checkpoint (GO:0072395)3.82371243
39respiratory electron transport chain (GO:0022904)3.80293197
40transcription from RNA polymerase I promoter (GO:0006360)3.79308905
41transcription initiation from RNA polymerase I promoter (GO:0006361)3.75998021
42nucleotide-excision repair, DNA gap filling (GO:0006297)3.75877269
43electron transport chain (GO:0022900)3.74702943
44positive regulation of ligase activity (GO:0051351)3.73603095
45DNA-dependent DNA replication (GO:0006261)3.71589510
46negative regulation of organelle assembly (GO:1902116)3.61457564
47positive regulation of B cell differentiation (GO:0045579)3.53587576
48maturation of SSU-rRNA (GO:0030490)3.52318028
49mitotic recombination (GO:0006312)3.47663639
50polyketide metabolic process (GO:0030638)3.46770485
51doxorubicin metabolic process (GO:0044598)3.46770485
52daunorubicin metabolic process (GO:0044597)3.46770485
53regulation of ubiquitin-protein transferase activity (GO:0051438)3.43044581
54proteasome assembly (GO:0043248)3.42661345
55mismatch repair (GO:0006298)3.40632708
56mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.40284694
57mitochondrial respiratory chain complex I assembly (GO:0032981)3.40284694
58NADH dehydrogenase complex assembly (GO:0010257)3.40284694
59protein targeting to mitochondrion (GO:0006626)3.40137211
60L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.38345573
61CENP-A containing nucleosome assembly (GO:0034080)3.37134852
62dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.33918128
63mannosylation (GO:0097502)3.32856033
64positive regulation of viral transcription (GO:0050434)3.32769420
65regulation of ligase activity (GO:0051340)3.30146435
66telomere maintenance via telomere lengthening (GO:0010833)3.29986543
67transcription elongation from RNA polymerase II promoter (GO:0006368)3.29277823
68pseudouridine synthesis (GO:0001522)3.29229276
69purine nucleobase biosynthetic process (GO:0009113)3.29051340
70rRNA methylation (GO:0031167)3.25697029
71protein K6-linked ubiquitination (GO:0085020)3.24526153
72nucleotide-excision repair (GO:0006289)3.22523415
73DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.21918570
74positive regulation of protein homodimerization activity (GO:0090073)3.20540547
75mitotic metaphase plate congression (GO:0007080)3.20350763
76protein complex biogenesis (GO:0070271)3.19285664
77chromatin remodeling at centromere (GO:0031055)3.18730133
78DNA replication checkpoint (GO:0000076)3.18280466
79cytochrome complex assembly (GO:0017004)3.16463926
80ribosome assembly (GO:0042255)3.15700566
81tRNA methylation (GO:0030488)3.14378746
82RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.14230484
83tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.14230484
84nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.13104465
85positive regulation of cell cycle arrest (GO:0071158)3.13041004
86adenosine metabolic process (GO:0046085)3.12261443
87establishment of protein localization to mitochondrion (GO:0072655)3.12044182
88exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.10287519
89protein localization to mitochondrion (GO:0070585)3.09912516
90negative regulation of protein ubiquitination (GO:0031397)3.09700792
91methionine biosynthetic process (GO:0009086)3.04854230
92hair cell differentiation (GO:0035315)3.04564249
93methionine metabolic process (GO:0006555)3.03857228
94regulation of cellular amine metabolic process (GO:0033238)3.03785745
95mitochondrial respiratory chain complex assembly (GO:0033108)3.03464911
96amino acid activation (GO:0043038)3.03447725
97tRNA aminoacylation (GO:0043039)3.03447725
98L-methionine salvage (GO:0071267)3.02895768
99L-methionine biosynthetic process (GO:0071265)3.02895768
100amino acid salvage (GO:0043102)3.02895768
101rRNA processing (GO:0006364)3.02586480
102tRNA aminoacylation for protein translation (GO:0006418)3.02524335
103antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.02343224
104establishment of integrated proviral latency (GO:0075713)3.00978684
105protein neddylation (GO:0045116)3.00877545
106water-soluble vitamin biosynthetic process (GO:0042364)2.99704481
107metaphase plate congression (GO:0051310)2.98766428
108folic acid metabolic process (GO:0046655)2.98475113
109deoxyribonucleotide biosynthetic process (GO:0009263)2.98078328
110transcription elongation from RNA polymerase III promoter (GO:0006385)2.97931520
111termination of RNA polymerase III transcription (GO:0006386)2.97931520
112ATP synthesis coupled proton transport (GO:0015986)2.96987732
113energy coupled proton transport, down electrochemical gradient (GO:0015985)2.96987732
114protein-cofactor linkage (GO:0018065)2.96879895
115negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.96713350
116purine nucleotide salvage (GO:0032261)2.96385473
117deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.96370997
118translation (GO:0006412)2.94704697
119mitotic sister chromatid segregation (GO:0000070)2.94071886
120pteridine-containing compound biosynthetic process (GO:0042559)2.93961890
121nucleobase biosynthetic process (GO:0046112)2.92667138
122rRNA metabolic process (GO:0016072)2.91741102
123respiratory chain complex IV assembly (GO:0008535)2.91615264
124regulation of receptor recycling (GO:0001919)2.88804718
125cellular component biogenesis (GO:0044085)2.88396336
126kinetochore assembly (GO:0051382)2.88105930
127DNA ligation (GO:0006266)2.87774209
1282-deoxyribonucleotide biosynthetic process (GO:0009265)2.87750223
129deoxyribose phosphate biosynthetic process (GO:0046385)2.87750223
130negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.87305147
131DNA catabolic process, exonucleolytic (GO:0000738)2.85736571
132pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.85306234
133ribosomal large subunit biogenesis (GO:0042273)2.84303320
134establishment of viral latency (GO:0019043)2.83273911
135signal transduction in response to DNA damage (GO:0042770)2.82571747
136regulation of mitochondrial translation (GO:0070129)2.81213699
137tRNA modification (GO:0006400)2.80534175
138positive regulation of TOR signaling (GO:0032008)2.79683931
139rRNA modification (GO:0000154)2.78942485
140DNA-templated transcription, elongation (GO:0006354)2.78886681
141regulation of cholesterol efflux (GO:0010874)2.76391020
142pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.75181560
143maturation of 5.8S rRNA (GO:0000460)2.74749176
144base-excision repair, AP site formation (GO:0006285)2.73864136
145mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.72674989
146quinone biosynthetic process (GO:1901663)2.71109133
147ubiquinone biosynthetic process (GO:0006744)2.71109133
148regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.70976117
149viral transcription (GO:0019083)2.67743344
150positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.66214190
151mitochondrial DNA replication (GO:0006264)2.65273728
152spliceosomal snRNP assembly (GO:0000387)2.65241466
153DNA-templated transcription, termination (GO:0006353)2.64843567
154DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.63756829
155tRNA processing (GO:0008033)2.63639902
156signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.63419516
157signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.63419516
158signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.63419516
159viral mRNA export from host cell nucleus (GO:0046784)2.62984426
160negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.60426377
161negative regulation of ligase activity (GO:0051352)2.60426377

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.74638010
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.17607879
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.36675034
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.29261114
5MYC_18555785_ChIP-Seq_MESCs_Mouse4.11875378
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.64469300
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.42763570
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.42670455
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.27107884
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.00951673
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.91792051
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.79535951
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.72825757
14* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.71835531
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.69350468
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.60912314
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.58445486
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.51501620
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.43063556
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.33437904
21* YY1_21170310_ChIP-Seq_MESCs_Mouse2.26805478
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.26734143
23* FOXP3_21729870_ChIP-Seq_TREG_Human2.24792102
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.23852396
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.21842448
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.13700852
27FOXM1_23109430_ChIP-Seq_U2OS_Human2.10609519
28* VDR_23849224_ChIP-Seq_CD4+_Human2.05336471
29CIITA_25753668_ChIP-Seq_RAJI_Human2.04412444
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.98310224
31FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.97087347
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.95713580
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.95615886
34MYC_19079543_ChIP-ChIP_MESCs_Mouse1.95047566
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.93189877
36PADI4_21655091_ChIP-ChIP_MCF-7_Human1.91787500
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.84268183
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.83514318
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.82269642
40DCP1A_22483619_ChIP-Seq_HELA_Human1.78412734
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.75924760
42NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75659007
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.69909163
44XRN2_22483619_ChIP-Seq_HELA_Human1.67089101
45GABP_19822575_ChIP-Seq_HepG2_Human1.65532008
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.59016720
47* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58727571
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.58387053
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51194596
50CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.51099611
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48798750
52* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45371874
53SCL_19346495_ChIP-Seq_HPC-7_Human1.43824693
54TTF2_22483619_ChIP-Seq_HELA_Human1.43377719
55ELK1_19687146_ChIP-ChIP_HELA_Human1.37166342
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33076651
57* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31803428
58IRF1_19129219_ChIP-ChIP_H3396_Human1.29109575
59STAT1_20625510_ChIP-Seq_HELA_Human1.28222590
60AR_21909140_ChIP-Seq_LNCAP_Human1.27963753
61ZNF274_21170338_ChIP-Seq_K562_Hela1.27667287
62CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.27269903
63* MYC_18940864_ChIP-ChIP_HL60_Human1.25972998
64ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24955097
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.23643233
66EWS_26573619_Chip-Seq_HEK293_Human1.21666711
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.16919564
68SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16565411
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14451875
70VDR_22108803_ChIP-Seq_LS180_Human1.12884147
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12396716
72LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11606966
73KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.10307859
74EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08677284
75EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08285328
76CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08059845
77* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06690527
78CTCF_18555785_ChIP-Seq_MESCs_Mouse1.06389116
79CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.06241154
80IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.04530894
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03301892
82MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.03274277
83FUS_26573619_Chip-Seq_HEK293_Human1.01520238
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01137312
85E2F1_21310950_ChIP-Seq_MCF-7_Human1.00199736
86GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98468967
87FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98436727
88SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96832106
89IRF8_22096565_ChIP-ChIP_GC-B_Human0.95614721
90KDM5A_27292631_Chip-Seq_BREAST_Human0.92721953
91CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90468258
92HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90029489
93ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89671747
94KAP1_22055183_ChIP-Seq_ESCs_Mouse0.87452190
95* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86521933
96LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.85532362
97PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.84242951
98RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.84044272
99CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.82822711
100SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81986868
101DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81413860
102SPI1_23547873_ChIP-Seq_NB4_Human0.81376990
103ELF5_23300383_ChIP-Seq_T47D_Human0.80605529
104BP1_19119308_ChIP-ChIP_Hs578T_Human0.80044227
105E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.79651097
106SOX17_20123909_ChIP-Seq_XEN_Mouse0.78015322
107* GATA3_21867929_ChIP-Seq_CD8_Mouse0.77064216
108ELK1_22589737_ChIP-Seq_MCF10A_Human0.77010597
109KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.76626589
110TP53_22573176_ChIP-Seq_HFKS_Human0.74680852
111PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.73910108
112FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73133314
113CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.73059354
114TFEB_21752829_ChIP-Seq_HELA_Human0.71728562
115TBX5_21415370_ChIP-Seq_HL-1_Mouse0.70712497
116ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.69441125
117SALL4_22934838_ChIP-ChIP_CD34+_Human0.66985755
118RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.66026165
119BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.64458067
120AR_20517297_ChIP-Seq_VCAP_Human0.64242167
121* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.64061676
122ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.63192819

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002938_white_spotting4.58390099
2MP0000013_abnormal_adipose_tissue4.30171836
3MP0002102_abnormal_ear_morphology4.24698854
4MP0008058_abnormal_DNA_repair3.77696180
5MP0003878_abnormal_ear_physiology3.76971286
6MP0005377_hearing/vestibular/ear_phenot3.76971286
7MP0006292_abnormal_olfactory_placode3.57013356
8MP0003786_premature_aging3.45394828
9MP0003693_abnormal_embryo_hatching2.42330897
10MP0000566_synostosis2.37873728
11MP0010094_abnormal_chromosome_stability2.30704569
12MP0003111_abnormal_nucleus_morphology2.27565528
13MP0002132_abnormal_respiratory_system2.26007984
14MP0010307_abnormal_tumor_latency2.10282399
15MP0002163_abnormal_gland_morphology2.04787421
16MP0005084_abnormal_gallbladder_morpholo2.02912848
17MP0001835_abnormal_antigen_presentation1.95071216
18MP0005645_abnormal_hypothalamus_physiol1.87533560
19MP0009697_abnormal_copulation1.86008146
20MP0002638_abnormal_pupillary_reflex1.77987268
21MP0008007_abnormal_cellular_replicative1.77021606
22MP0005379_endocrine/exocrine_gland_phen1.75492787
23MP0002138_abnormal_hepatobiliary_system1.73163968
24MP0008789_abnormal_olfactory_epithelium1.67116819
25MP0003950_abnormal_plasma_membrane1.64182794
26MP0006036_abnormal_mitochondrial_physio1.63777284
27MP0003879_abnormal_hair_cell1.62016937
28MP0006276_abnormal_autonomic_nervous1.60002762
29MP0001485_abnormal_pinna_reflex1.59553047
30MP0009379_abnormal_foot_pigmentation1.59335379
31MP0000358_abnormal_cell_content/1.56862694
32MP0005408_hypopigmentation1.56217747
33MP0005646_abnormal_pituitary_gland1.53110166
34MP0003077_abnormal_cell_cycle1.53107045
35MP0005360_urolithiasis1.50626089
36MP0001529_abnormal_vocalization1.49395586
37MP0003186_abnormal_redox_activity1.48194050
38MP0002396_abnormal_hematopoietic_system1.47220945
39MP0003806_abnormal_nucleotide_metabolis1.45636600
40MP0002837_dystrophic_cardiac_calcinosis1.45399924
41MP0003195_calcinosis1.44358173
42MP0005365_abnormal_bile_salt1.42630515
43MP0006072_abnormal_retinal_apoptosis1.39641088
44MP0000003_abnormal_adipose_tissue1.36201594
45MP0008995_early_reproductive_senescence1.34518993
46MP0008057_abnormal_DNA_replication1.29903307
47MP0003646_muscle_fatigue1.28842548
48MP0005174_abnormal_tail_pigmentation1.27842994
49MP0003890_abnormal_embryonic-extraembry1.25725130
50MP0005332_abnormal_amino_acid1.24425737
51MP0004147_increased_porphyrin_level1.24370164
52MP0005499_abnormal_olfactory_system1.23490487
53MP0005394_taste/olfaction_phenotype1.23490487
54MP0001929_abnormal_gametogenesis1.20583163
55MP0000749_muscle_degeneration1.15663879
56MP0000350_abnormal_cell_proliferation1.14104658
57MP0005075_abnormal_melanosome_morpholog1.13336959
58MP0001188_hyperpigmentation1.12914645
59MP0001764_abnormal_homeostasis1.12230644
60MP0001984_abnormal_olfaction1.11667894
61MP0004957_abnormal_blastocyst_morpholog1.10195040
62MP0003656_abnormal_erythrocyte_physiolo1.09968067
63MP0002254_reproductive_system_inflammat1.08821848
64MP0001730_embryonic_growth_arrest1.07220755
65MP0005085_abnormal_gallbladder_physiolo1.06566532
66MP0004142_abnormal_muscle_tone1.03274052
67MP0001727_abnormal_embryo_implantation1.01259272
68MP0000015_abnormal_ear_pigmentation1.01141947
69MP0005266_abnormal_metabolism1.00298792
70MP0005395_other_phenotype0.99579661
71MP0001986_abnormal_taste_sensitivity0.98968324
72MP0010386_abnormal_urinary_bladder0.98946543
73MP0002148_abnormal_hypersensitivity_rea0.95507068
74MP0001346_abnormal_lacrimal_gland0.93747329
75MP0008873_increased_physiological_sensi0.92454289
76MP0001697_abnormal_embryo_size0.92093799
77MP0002751_abnormal_autonomic_nervous0.91988113
78MP0003763_abnormal_thymus_physiology0.91964269
79MP0006035_abnormal_mitochondrial_morpho0.91861679
80MP0001324_abnormal_eye_pigmentation0.88800327
81MP0009333_abnormal_splenocyte_physiolog0.88655939
82MP0005410_abnormal_fertilization0.87708350
83MP0002210_abnormal_sex_determination0.87155477
84MP0008875_abnormal_xenobiotic_pharmacok0.86849286
85MP0002735_abnormal_chemical_nociception0.86679780
86MP0003880_abnormal_central_pattern0.86505927
87MP0000613_abnormal_salivary_gland0.86192617
88MP0002234_abnormal_pharynx_morphology0.86001164
89MP0000689_abnormal_spleen_morphology0.85726369
90MP0001881_abnormal_mammary_gland0.85432776
91MP0002398_abnormal_bone_marrow0.85159673
92MP0001119_abnormal_female_reproductive0.83463647
93MP0001800_abnormal_humoral_immune0.82217592
94MP0003724_increased_susceptibility_to0.82084146
95MP0009046_muscle_twitch0.81953617
96MP0004133_heterotaxia0.81325025
97MP0001919_abnormal_reproductive_system0.80926804
98MP0003718_maternal_effect0.80470948
99MP0008932_abnormal_embryonic_tissue0.80138234
100MP0002095_abnormal_skin_pigmentation0.80088753
101MP0005220_abnormal_exocrine_pancreas0.79164597
102MP0005551_abnormal_eye_electrophysiolog0.79002833
103MP0003011_delayed_dark_adaptation0.78898342
104MP0009785_altered_susceptibility_to0.76024021
105MP0002019_abnormal_tumor_incidence0.75941281
106MP0005671_abnormal_response_to0.75891424
107MP0000049_abnormal_middle_ear0.75469310
108MP0005253_abnormal_eye_physiology0.74196052
109MP0002429_abnormal_blood_cell0.74042036
110MP0002722_abnormal_immune_system0.73448598
111MP0002160_abnormal_reproductive_system0.73340412
112MP0001145_abnormal_male_reproductive0.73273022
113MP0001873_stomach_inflammation0.73116934
114MP0003787_abnormal_imprinting0.72076680
115MP0008872_abnormal_physiological_respon0.71787354
116MP0002006_tumorigenesis0.71725602
117MP0000653_abnormal_sex_gland0.70838664
118MP0000372_irregular_coat_pigmentation0.70769295
119MP0005647_abnormal_sex_gland0.69426595
120MP0003698_abnormal_male_reproductive0.69188910
121MP0003943_abnormal_hepatobiliary_system0.68819025
122MP0004134_abnormal_chest_morphology0.68764044
123MP0002080_prenatal_lethality0.68271309
124MP0000490_abnormal_crypts_of0.67408160
125MP0001853_heart_inflammation0.66562230
126MP0004742_abnormal_vestibular_system0.66523208
127MP0004782_abnormal_surfactant_physiolog0.66410467
128MP0002139_abnormal_hepatobiliary_system0.66126024
129MP0002452_abnormal_antigen_presenting0.65817684
130MP0005636_abnormal_mineral_homeostasis0.65386207
131MP0008877_abnormal_DNA_methylation0.64115924
132MP0000716_abnormal_immune_system0.63963493
133MP0001293_anophthalmia0.63560547
134MP0003123_paternal_imprinting0.62534001
135MP0002249_abnormal_larynx_morphology0.62273229
136MP0002420_abnormal_adaptive_immunity0.61675909
137MP0002277_abnormal_respiratory_mucosa0.60876128
138MP0005389_reproductive_system_phenotype0.60753477
139MP0010030_abnormal_orbit_morphology0.60531050
140MP0003699_abnormal_female_reproductive0.60187775
141MP0001819_abnormal_immune_cell0.60001359
142MP0000313_abnormal_cell_death0.59850112
143MP0001905_abnormal_dopamine_level0.59193879
144MP0003936_abnormal_reproductive_system0.59149722
145MP0001944_abnormal_pancreas_morphology0.58311165
146MP0003137_abnormal_impulse_conducting0.58059288
147MP0000647_abnormal_sebaceous_gland0.56978253
148MP0002269_muscular_atrophy0.56938214

Predicted human phenotypes

RankGene SetZ-score
1Entropion (HP:0000621)7.17467217
2Poikiloderma (HP:0001029)6.78378701
3Abnormality of DNA repair (HP:0003254)6.73730778
4Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.50875591
5Prominent metopic ridge (HP:0005487)5.02533926
6Abnormality of the metopic suture (HP:0005556)4.53054504
7Generalized aminoaciduria (HP:0002909)4.23956403
8Decreased subcutaneous fat (HP:0001002)4.15963471
9Renal Fanconi syndrome (HP:0001994)4.05474060
10Erythroderma (HP:0001019)3.86848080
11Methylmalonic acidemia (HP:0002912)3.69399222
12Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.56516477
13Decreased activity of mitochondrial respiratory chain (HP:0008972)3.56516477
14Abnormal number of erythroid precursors (HP:0012131)3.48248747
15Congenital ichthyosiform erythroderma (HP:0007431)3.47658621
16Aplastic anemia (HP:0001915)3.41940143
17Fragile nails (HP:0001808)3.38669198
18Abnormality of cells of the erythroid lineage (HP:0012130)3.35294615
19Increased intramyocellular lipid droplets (HP:0012240)3.35174455
20Chromosomal breakage induced by crosslinking agents (HP:0003221)3.30960808
213-Methylglutaconic aciduria (HP:0003535)3.26401812
22Keratitis (HP:0000491)3.23740338
23Abnormality of the heme biosynthetic pathway (HP:0010472)3.18647266
24Methylmalonic aciduria (HP:0012120)3.16856566
25Abnormality of subcutaneous fat tissue (HP:0001001)3.06964403
26IgG deficiency (HP:0004315)3.04854705
27Chromsome breakage (HP:0040012)3.01947959
28Birth length less than 3rd percentile (HP:0003561)3.00936537
29Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.00604006
30Ectropion (HP:0000656)3.00508222
31Progressive macrocephaly (HP:0004481)2.96251934
32Death in childhood (HP:0003819)2.91657052
33Thyroid-stimulating hormone excess (HP:0002925)2.90275254
34Hepatocellular necrosis (HP:0001404)2.80811776
35Respiratory failure (HP:0002878)2.80702227
36Hepatic necrosis (HP:0002605)2.74106903
37Mitochondrial inheritance (HP:0001427)2.73805316
38Abnormality of glycolysis (HP:0004366)2.73608317
39Acute necrotizing encephalopathy (HP:0006965)2.73495399
40Abnormal gallbladder physiology (HP:0012438)2.71784934
41Cholecystitis (HP:0001082)2.71784934
42Increased serum pyruvate (HP:0003542)2.68964114
43Increased muscle lipid content (HP:0009058)2.62962353
44Abnormality of methionine metabolism (HP:0010901)2.62207336
45Stomach cancer (HP:0012126)2.61108360
46Type I transferrin isoform profile (HP:0003642)2.59767761
47Increased CSF lactate (HP:0002490)2.56109432
48Recurrent corneal erosions (HP:0000495)2.53451781
49Reticulocytopenia (HP:0001896)2.48801786
50Brittle hair (HP:0002299)2.48778753
51Abnormality of renal resorption (HP:0011038)2.42116704
52Abnormal mitochondria in muscle tissue (HP:0008316)2.41961531
53CNS demyelination (HP:0007305)2.41550153
54Increased serum lactate (HP:0002151)2.41470397
55Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.41100105
56Degeneration of anterior horn cells (HP:0002398)2.39554267
57Abnormality of the anterior horn cell (HP:0006802)2.39554267
58Abnormality of the labia minora (HP:0012880)2.37155006
59Nephroblastoma (Wilms tumor) (HP:0002667)2.35714043
60Pancreatic cysts (HP:0001737)2.35603617
61Optic disc pallor (HP:0000543)2.32712456
62Abnormality of the pons (HP:0007361)2.32679062
63Increased hepatocellular lipid droplets (HP:0006565)2.32214002
64Lethargy (HP:0001254)2.31389475
65Abnormality of vitamin B metabolism (HP:0004340)2.29697449
66Acute encephalopathy (HP:0006846)2.21692087
67Abnormality of chromosome stability (HP:0003220)2.18791620
68Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.18180274
69Abnormality of aspartate family amino acid metabolism (HP:0010899)2.17714088
70Cone-rod dystrophy (HP:0000548)2.17648673
71Lactic acidosis (HP:0003128)2.15752463
72Embryonal renal neoplasm (HP:0011794)2.15387972
73Abnormality of urine glucose concentration (HP:0011016)2.14166377
74Glycosuria (HP:0003076)2.14166377
75Short tibia (HP:0005736)2.14092277
76Duplicated collecting system (HP:0000081)2.13282888
77Pallor (HP:0000980)2.12562121
78Abnormality of the renal collecting system (HP:0004742)2.12555139
79Hypoplasia of the pons (HP:0012110)2.11480513
80Abnormality of pyrimidine metabolism (HP:0004353)2.11197663
81Abnormality of the vitamin B12 metabolism (HP:0004341)2.11185096
82Pancreatic fibrosis (HP:0100732)2.08777571
83Reduced antithrombin III activity (HP:0001976)2.08461439
84Small intestinal stenosis (HP:0012848)2.07107366
85Duodenal stenosis (HP:0100867)2.07107366
86Leukodystrophy (HP:0002415)2.06273168
87Medial flaring of the eyebrow (HP:0010747)2.04962909
88Male infertility (HP:0003251)2.04293233
89Abnormality of midbrain morphology (HP:0002418)2.03561840
90Molar tooth sign on MRI (HP:0002419)2.03561840
91Lipid accumulation in hepatocytes (HP:0006561)2.02275665
92Abnormality of fatty-acid metabolism (HP:0004359)2.00604969
93Abnormality of alanine metabolism (HP:0010916)1.98497921
94Hyperalaninemia (HP:0003348)1.98497921
95Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.98497921
96Scrotal hypoplasia (HP:0000046)1.97664546
97Failure to thrive in infancy (HP:0001531)1.97003303
98Exertional dyspnea (HP:0002875)1.96994589
99Oral leukoplakia (HP:0002745)1.96919978
100Nausea (HP:0002018)1.96758829
101Conjugated hyperbilirubinemia (HP:0002908)1.96536044
102Hyperglycinemia (HP:0002154)1.94359293
103Aplasia/Hypoplasia of the sacrum (HP:0008517)1.92555595
104Microretrognathia (HP:0000308)1.89851036
105Macrocytic anemia (HP:0001972)1.89739201
106Cerebral palsy (HP:0100021)1.89623472
107Abnormality of the fovea (HP:0000493)1.89310141
108Abnormal protein glycosylation (HP:0012346)1.89297099
109Abnormal glycosylation (HP:0012345)1.89297099
110Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.89297099
111Abnormal protein N-linked glycosylation (HP:0012347)1.89297099
112Abnormality of the preputium (HP:0100587)1.88478292
113Microvesicular hepatic steatosis (HP:0001414)1.86018550
114Abnormality of the duodenum (HP:0002246)1.85042547
115Muscle fiber atrophy (HP:0100295)1.84685690
116Aplasia/Hypoplasia of the tibia (HP:0005772)1.84403858
117Conjunctival hamartoma (HP:0100780)1.83552753
118Abnormal lung lobation (HP:0002101)1.83192344
119Alveolar cell carcinoma (HP:0006519)1.82841156
120Aplasia/Hypoplasia of the fovea (HP:0008060)1.81667184
121Hypoplasia of the fovea (HP:0007750)1.81667184
122Exercise intolerance (HP:0003546)1.81650120
123Dicarboxylic aciduria (HP:0003215)1.80873628
124Abnormality of dicarboxylic acid metabolism (HP:0010995)1.80873628
125True hermaphroditism (HP:0010459)1.80548220
126Abnormality of serum amino acid levels (HP:0003112)1.80493339
127Emotional lability (HP:0000712)1.79678128
128Hypophosphatemic rickets (HP:0004912)1.79612712
129Absent thumb (HP:0009777)1.78009139
130Clubbing of toes (HP:0100760)1.77512953
131Abnormality of sulfur amino acid metabolism (HP:0004339)1.76562680
132Abnormality of the costochondral junction (HP:0000919)1.76210960
133B lymphocytopenia (HP:0010976)1.75748169
134Cerebral edema (HP:0002181)1.73908776
135Breast hypoplasia (HP:0003187)1.73290018
136Meckel diverticulum (HP:0002245)1.72912274
137Abnormality of placental membranes (HP:0011409)1.72237928
138Amniotic constriction ring (HP:0009775)1.72237928
139Secondary amenorrhea (HP:0000869)1.70488230
140Testicular atrophy (HP:0000029)1.70445075
141Cutaneous photosensitivity (HP:0000992)1.69841987
142Optic nerve coloboma (HP:0000588)1.69709604
143Myelodysplasia (HP:0002863)1.68467205
144Abnormality of the septum pellucidum (HP:0007375)1.66630416
145Abnormality of the ileum (HP:0001549)1.65892381
146Aplasia/Hypoplasia of the uvula (HP:0010293)1.63352354
14711 pairs of ribs (HP:0000878)1.62195419
148Pancytopenia (HP:0001876)1.61935739
149Triphalangeal thumb (HP:0001199)1.61143814
150Hyponatremia (HP:0002902)1.60590732
151Septo-optic dysplasia (HP:0100842)1.59670476
152Respiratory difficulties (HP:0002880)1.59470906
153Type 2 muscle fiber atrophy (HP:0003554)1.55885923
154Female pseudohermaphroditism (HP:0010458)1.54687216
155Megaloblastic anemia (HP:0001889)1.53390146

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.07996905
2STK163.73122447
3IRAK23.37820120
4NEK13.18536699
5MST43.07733063
6VRK23.04566380
7CASK2.81783093
8PINK12.79965327
9TRIM282.78642678
10SRPK12.76882227
11BRAF2.69208393
12TNIK2.52053431
13NME22.46062543
14CDK82.44474713
15PBK2.29462096
16IRAK42.14799175
17MKNK22.14456285
18VRK12.03051645
19PDK21.82080878
20ZAK1.80988912
21BMPR1B1.79735795
22IRAK31.79180163
23MKNK11.78750297
24MAP4K21.73316374
25BCKDK1.52881697
26PRPF4B1.50752334
27INSRR1.48663479
28CCNB11.38985350
29FRK1.37838887
30CSNK1G31.37577323
31YES11.36580561
32EIF2AK11.35275339
33WEE11.31278003
34MAP2K71.31184652
35WNK31.31142542
36SIK31.22019255
37CSNK1G11.20991843
38TXK1.17941798
39KIT1.16358365
40PIM21.16131174
41TGFBR11.11351377
42CDC71.10469499
43EIF2AK21.10377801
44DYRK21.09870117
45TSSK61.09466506
46BMPR21.09122801
47TAOK21.06643040
48CSNK1A1L1.06613684
49MAPK131.05174100
50SGK21.03612769
51EIF2AK31.03008717
52MUSK1.02767070
53DYRK31.01687892
54MAP4K11.01358251
55CSNK1G21.01347755
56TESK21.00677038
57TEC1.00389854
58CDK71.00224886
59PLK40.99478064
60MAP2K20.98589417
61ATR0.96135239
62PAK40.89787863
63LIMK10.89517966
64BCR0.88142076
65BRSK10.87737366
66NEK20.87723759
67MAPKAPK30.87215864
68PLK10.86644905
69ADRBK20.82408418
70TTK0.81741008
71TAOK10.80439497
72NUAK10.80305613
73MAP3K120.79218837
74NME10.77915810
75ARAF0.77462154
76PLK30.77353995
77TAF10.77180888
78SYK0.75059375
79DAPK10.74485485
80BTK0.72710583
81TIE10.71287692
82CLK10.70585350
83MAP3K40.70507513
84AURKA0.68556663
85OBSCN0.67988538
86TESK10.66157967
87AKT30.65129562
88ERBB40.64782547
89CHEK20.63269856
90GRK10.62314213
91GRK70.62064806
92PASK0.61981478
93NLK0.61235707
94ERBB30.61214833
95STK100.60499253
96TLK10.60366016
97LYN0.60214993
98MYLK0.59847347
99BRSK20.59595249
100MAP3K140.59398653
101IKBKB0.59240290
102ATM0.58215497
103TNK20.57043901
104MAP3K60.55629329
105FLT30.54882295
106MARK10.52806730
107SGK4940.52675663
108SGK2230.52675663
109CSNK2A10.52383019
110CHEK10.52030146
111PIM10.51272422
112TYK20.50510404
113BRD40.50127562
114MAP2K60.49670343
115STK240.48550733
116STK40.47623787
117MAPK40.46767089
118PRKCI0.46211978
119JAK30.43912784
120RPS6KA50.43783561
121AURKB0.42966144
122PLK20.42603630
123MAP3K80.40037095
124DYRK1A0.40003534
125AKT20.39311441
126IKBKE0.39049204
127MAP3K50.38877276
128CSNK2A20.37745413
129FES0.37451504
130PAK10.36192890
131MARK30.34015244
132ABL20.33456456
133CSNK1A10.32737750
134ILK0.31040052
135RPS6KB20.30918805
136KDR0.30641320
137CSNK1E0.29549042
138PRKCE0.29437195
139MAP3K90.27481527

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.53799224
2Mismatch repair_Homo sapiens_hsa034304.17442569
3RNA polymerase_Homo sapiens_hsa030203.93680838
4Nucleotide excision repair_Homo sapiens_hsa034203.75358806
5Homologous recombination_Homo sapiens_hsa034403.29423762
6Ribosome_Homo sapiens_hsa030103.22422084
7Proteasome_Homo sapiens_hsa030503.10676538
8Base excision repair_Homo sapiens_hsa034103.03115051
9Pyrimidine metabolism_Homo sapiens_hsa002402.85800683
10Basal transcription factors_Homo sapiens_hsa030222.78504453
11Fanconi anemia pathway_Homo sapiens_hsa034602.32090442
12Oxidative phosphorylation_Homo sapiens_hsa001902.09818810
13One carbon pool by folate_Homo sapiens_hsa006702.01506801
14Spliceosome_Homo sapiens_hsa030401.99341522
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.91216803
16Parkinsons disease_Homo sapiens_hsa050121.86801318
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.76536490
18Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.68565023
19Purine metabolism_Homo sapiens_hsa002301.67275631
20Huntingtons disease_Homo sapiens_hsa050161.59771962
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.57089247
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53753921
23Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.48950468
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.47415383
25RNA degradation_Homo sapiens_hsa030181.44629073
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.44457915
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38216614
28Sulfur metabolism_Homo sapiens_hsa009201.33907863
29Protein export_Homo sapiens_hsa030601.33301856
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.33097622
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33032521
32Non-homologous end-joining_Homo sapiens_hsa034501.27796046
33RNA transport_Homo sapiens_hsa030131.22345561
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22109765
35Steroid biosynthesis_Homo sapiens_hsa001001.19270830
36Sulfur relay system_Homo sapiens_hsa041221.14460500
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11564050
38Alzheimers disease_Homo sapiens_hsa050101.11294913
39Folate biosynthesis_Homo sapiens_hsa007901.11016566
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.06563638
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06046984
42Butanoate metabolism_Homo sapiens_hsa006501.04771008
43Cell cycle_Homo sapiens_hsa041101.01240581
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00374516
45Primary immunodeficiency_Homo sapiens_hsa053400.97044894
46Peroxisome_Homo sapiens_hsa041460.81760241
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81441348
48Primary bile acid biosynthesis_Homo sapiens_hsa001200.77784234
49Fructose and mannose metabolism_Homo sapiens_hsa000510.77340521
50Selenocompound metabolism_Homo sapiens_hsa004500.76279568
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74456145
52Metabolic pathways_Homo sapiens_hsa011000.74381654
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70273032
54Epstein-Barr virus infection_Homo sapiens_hsa051690.66371676
55Oocyte meiosis_Homo sapiens_hsa041140.65599156
56Fatty acid elongation_Homo sapiens_hsa000620.59879842
57Vitamin B6 metabolism_Homo sapiens_hsa007500.59419786
58Retinol metabolism_Homo sapiens_hsa008300.58050449
59Regulation of autophagy_Homo sapiens_hsa041400.57124269
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56839374
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56578525
62Glutathione metabolism_Homo sapiens_hsa004800.56448813
63beta-Alanine metabolism_Homo sapiens_hsa004100.55486263
64Chemical carcinogenesis_Homo sapiens_hsa052040.54897776
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54305025
66NF-kappa B signaling pathway_Homo sapiens_hsa040640.54128005
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52963393
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52358274
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.50977688
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50608777
71Arginine and proline metabolism_Homo sapiens_hsa003300.50586471
72mRNA surveillance pathway_Homo sapiens_hsa030150.50321822
73Collecting duct acid secretion_Homo sapiens_hsa049660.49041600
74Biosynthesis of amino acids_Homo sapiens_hsa012300.48999444
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48142577
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48076238
77Pyruvate metabolism_Homo sapiens_hsa006200.47143386
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.46689540
79Carbon metabolism_Homo sapiens_hsa012000.45949278
80Phototransduction_Homo sapiens_hsa047440.45369548
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.43567106
82Pentose phosphate pathway_Homo sapiens_hsa000300.42711587
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42373310
84Hematopoietic cell lineage_Homo sapiens_hsa046400.42162811
85Vitamin digestion and absorption_Homo sapiens_hsa049770.41004718
86* SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39964309
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39663145
88Measles_Homo sapiens_hsa051620.39219967
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38939473
90Herpes simplex infection_Homo sapiens_hsa051680.37261643
91Phenylalanine metabolism_Homo sapiens_hsa003600.37104737
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35358101
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.35187887
94Cardiac muscle contraction_Homo sapiens_hsa042600.34579403
95Arachidonic acid metabolism_Homo sapiens_hsa005900.33727317
96Propanoate metabolism_Homo sapiens_hsa006400.33608218
97Galactose metabolism_Homo sapiens_hsa000520.32259857
98B cell receptor signaling pathway_Homo sapiens_hsa046620.31659311
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29920403
100Vibrio cholerae infection_Homo sapiens_hsa051100.29540389
101Tryptophan metabolism_Homo sapiens_hsa003800.28920805
102p53 signaling pathway_Homo sapiens_hsa041150.28337953
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27965301
104Sphingolipid metabolism_Homo sapiens_hsa006000.27411451
105Tyrosine metabolism_Homo sapiens_hsa003500.26845493
106N-Glycan biosynthesis_Homo sapiens_hsa005100.26759014
107Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.26529436
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.26474860
109Nitrogen metabolism_Homo sapiens_hsa009100.25534624
110Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25435972
111Caffeine metabolism_Homo sapiens_hsa002320.25375858
112Legionellosis_Homo sapiens_hsa051340.24411736
113Influenza A_Homo sapiens_hsa051640.23746037
114ABC transporters_Homo sapiens_hsa020100.23704011
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23274277
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.22074824
117Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21313958
118Nicotine addiction_Homo sapiens_hsa050330.21165465
119Fatty acid metabolism_Homo sapiens_hsa012120.18327035
120Systemic lupus erythematosus_Homo sapiens_hsa053220.14548141
121Histidine metabolism_Homo sapiens_hsa003400.13465127
122Circadian rhythm_Homo sapiens_hsa047100.09786076

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