BNIP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)5.00326572
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.00326572
3NADH metabolic process (GO:0006734)4.90113575
4glycolytic process (GO:0006096)4.78462218
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.68817723
6L-phenylalanine metabolic process (GO:0006558)4.68817723
7tricarboxylic acid cycle (GO:0006099)4.28144828
8pyrimidine nucleobase catabolic process (GO:0006208)4.06795028
9aromatic amino acid family catabolic process (GO:0009074)4.02235208
10regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.01164218
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.99244164
12glyoxylate metabolic process (GO:0046487)3.93219367
13branched-chain amino acid catabolic process (GO:0009083)3.91118571
14succinate metabolic process (GO:0006105)3.89446042
15oxaloacetate metabolic process (GO:0006107)3.88425339
16regulation of sequestering of triglyceride (GO:0010889)3.86912605
17cellular ketone body metabolic process (GO:0046950)3.86782833
18regulation of acyl-CoA biosynthetic process (GO:0050812)3.85872329
19peptidyl-proline hydroxylation (GO:0019511)3.80352672
20regulation of cofactor metabolic process (GO:0051193)3.78303744
21regulation of coenzyme metabolic process (GO:0051196)3.78303744
22cholesterol biosynthetic process (GO:0006695)3.76510547
23lysine metabolic process (GO:0006553)3.74416508
24lysine catabolic process (GO:0006554)3.74416508
25protein hydroxylation (GO:0018126)3.68744733
26tyrosine metabolic process (GO:0006570)3.64698140
27serine family amino acid catabolic process (GO:0009071)3.63750446
282-oxoglutarate metabolic process (GO:0006103)3.63669864
29pyruvate metabolic process (GO:0006090)3.60461718
30alpha-linolenic acid metabolic process (GO:0036109)3.55976059
31ketone body metabolic process (GO:1902224)3.55527440
32biotin metabolic process (GO:0006768)3.54034959
33acylglycerol homeostasis (GO:0055090)3.52020870
34triglyceride homeostasis (GO:0070328)3.52020870
35fatty acid beta-oxidation (GO:0006635)3.51095255
36acetyl-CoA metabolic process (GO:0006084)3.48109162
37coenzyme catabolic process (GO:0009109)3.44570607
38triglyceride catabolic process (GO:0019433)3.40294025
39branched-chain amino acid metabolic process (GO:0009081)3.40095213
40cysteine metabolic process (GO:0006534)3.38069322
41fructose metabolic process (GO:0006000)3.37614539
42fatty acid oxidation (GO:0019395)3.37520115
43alpha-amino acid catabolic process (GO:1901606)3.37367728
44fatty acid transmembrane transport (GO:1902001)3.36016256
45nucleobase catabolic process (GO:0046113)3.35049105
46amino-acid betaine metabolic process (GO:0006577)3.34185401
47bile acid biosynthetic process (GO:0006699)3.33849984
48regulation of triglyceride catabolic process (GO:0010896)3.33029181
49fatty acid catabolic process (GO:0009062)3.32902054
50sterol biosynthetic process (GO:0016126)3.31801389
51lipid oxidation (GO:0034440)3.31614141
52complement activation, alternative pathway (GO:0006957)3.31211926
53valine metabolic process (GO:0006573)3.30167359
54plasma lipoprotein particle clearance (GO:0034381)3.30062169
55aromatic amino acid family metabolic process (GO:0009072)3.29879023
56fatty acid homeostasis (GO:0055089)3.29479122
57sulfur amino acid catabolic process (GO:0000098)3.28302062
58neutral lipid catabolic process (GO:0046461)3.27815762
59acylglycerol catabolic process (GO:0046464)3.27815762
60gluconeogenesis (GO:0006094)3.23486664
61urea metabolic process (GO:0019627)3.23264258
62urea cycle (GO:0000050)3.23264258
63kynurenine metabolic process (GO:0070189)3.22819043
64cellular amino acid catabolic process (GO:0009063)3.20442995
65aspartate family amino acid catabolic process (GO:0009068)3.18760133
66indole-containing compound catabolic process (GO:0042436)3.18234237
67indolalkylamine catabolic process (GO:0046218)3.18234237
68tryptophan catabolic process (GO:0006569)3.18234237
69glucose 6-phosphate metabolic process (GO:0051156)3.17952743
70hexose biosynthetic process (GO:0019319)3.17042881
71short-chain fatty acid metabolic process (GO:0046459)3.14997199
72acyl-CoA biosynthetic process (GO:0071616)3.12793902
73thioester biosynthetic process (GO:0035384)3.12793902
74postsynaptic membrane organization (GO:0001941)3.11975860
75carnitine shuttle (GO:0006853)3.11876211
76tryptophan metabolic process (GO:0006568)3.11086969
77establishment of mitochondrion localization (GO:0051654)3.08288128
78monocarboxylic acid catabolic process (GO:0072329)3.07181556
79L-serine metabolic process (GO:0006563)3.05911257
80organic acid catabolic process (GO:0016054)3.05418054
81carboxylic acid catabolic process (GO:0046395)3.05418054
82protein localization to synapse (GO:0035418)3.05035230
83peptidyl-glutamic acid carboxylation (GO:0017187)3.03742543
84protein carboxylation (GO:0018214)3.03742543
85fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.01719958
86regulation of sulfur metabolic process (GO:0042762)3.01714789
87high-density lipoprotein particle remodeling (GO:0034375)3.01139248
88positive regulation of fatty acid oxidation (GO:0046321)3.00590698
89nitrogen cycle metabolic process (GO:0071941)2.99327071
90low-density lipoprotein particle clearance (GO:0034383)2.98658629
914-hydroxyproline metabolic process (GO:0019471)2.97640577
92* positive regulation of mitochondrial fission (GO:0090141)2.96744800
93monosaccharide biosynthetic process (GO:0046364)2.96483911
94regulation of protein activation cascade (GO:2000257)2.95446242
95acyl-CoA metabolic process (GO:0006637)2.94984605
96thioester metabolic process (GO:0035383)2.94984605
97nonmotile primary cilium assembly (GO:0035058)2.93981586
98homocysteine metabolic process (GO:0050667)2.92827221
99dicarboxylic acid catabolic process (GO:0043649)2.92687344
100pantothenate metabolic process (GO:0015939)2.91164448
101negative regulation of fibrinolysis (GO:0051918)2.90646000
102bile acid metabolic process (GO:0008206)2.89444900
103positive regulation of fatty acid beta-oxidation (GO:0032000)2.87935529
104triglyceride biosynthetic process (GO:0019432)2.87573063
105fatty-acyl-CoA biosynthetic process (GO:0046949)2.84444250
106NAD metabolic process (GO:0019674)2.82690584
107regulation of complement activation (GO:0030449)2.79779673
108plasma lipoprotein particle remodeling (GO:0034369)2.78573656
109protein-lipid complex remodeling (GO:0034368)2.78573656
110macromolecular complex remodeling (GO:0034367)2.78573656
111positive regulation of lipid catabolic process (GO:0050996)2.78198511
112acylglycerol biosynthetic process (GO:0046463)2.77633236
113neutral lipid biosynthetic process (GO:0046460)2.77633236
114fatty-acyl-CoA metabolic process (GO:0035337)2.77323020
115arginine metabolic process (GO:0006525)2.76095208
116axonal fasciculation (GO:0007413)2.74622869
117presynaptic membrane assembly (GO:0097105)2.72575929
118retinal ganglion cell axon guidance (GO:0031290)2.68457244
119calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.66235233
120peptidyl-cysteine modification (GO:0018198)2.60962258
121presynaptic membrane organization (GO:0097090)2.59332159
122neurotransmitter-gated ion channel clustering (GO:0072578)2.56638058
123intraciliary transport (GO:0042073)2.53930833
124synaptic vesicle maturation (GO:0016188)2.52792648
125protein localization to cilium (GO:0061512)2.50395991
126layer formation in cerebral cortex (GO:0021819)2.48529205
127glutamate secretion (GO:0014047)2.48271995
128regulation of cilium movement (GO:0003352)2.45725995
129response to auditory stimulus (GO:0010996)2.44388801
130vascular smooth muscle contraction (GO:0014829)2.42670074
131C4-dicarboxylate transport (GO:0015740)2.40939013
132gamma-aminobutyric acid transport (GO:0015812)2.40387003
133substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.39421296
134substrate-independent telencephalic tangential migration (GO:0021826)2.39421296
135positive regulation of dendritic spine morphogenesis (GO:0061003)2.37067205
136auditory behavior (GO:0031223)2.34978483
137cullin deneddylation (GO:0010388)2.34479687
138synapse assembly (GO:0007416)2.33715447
139cilium morphogenesis (GO:0060271)2.32927905
140carbohydrate phosphorylation (GO:0046835)2.29673968
141establishment of melanosome localization (GO:0032401)2.27554570
142melanosome transport (GO:0032402)2.26468001
143glycosphingolipid biosynthetic process (GO:0006688)2.25613472
144olfactory bulb development (GO:0021772)2.25363933
145serine family amino acid biosynthetic process (GO:0009070)2.25253616
146neuron recognition (GO:0008038)2.23977619
147water-soluble vitamin biosynthetic process (GO:0042364)2.22507055
148aldehyde catabolic process (GO:0046185)2.19952709
149synaptic vesicle endocytosis (GO:0048488)2.19724207
150establishment of pigment granule localization (GO:0051905)2.18698148
151regulation of short-term neuronal synaptic plasticity (GO:0048172)2.18360160
152DNA integration (GO:0015074)2.18220828
153positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.17756111
154pigment granule transport (GO:0051904)2.17258403
155acidic amino acid transport (GO:0015800)2.15085435
156neuronal action potential propagation (GO:0019227)2.14887389
157synaptic vesicle docking involved in exocytosis (GO:0016081)2.14744341
158neuron cell-cell adhesion (GO:0007158)2.14666045
159negative regulation of protein localization to cell surface (GO:2000009)2.14460278
160dendritic spine morphogenesis (GO:0060997)2.14453325
161protein retention in ER lumen (GO:0006621)2.14045537
162neuronal ion channel clustering (GO:0045161)2.13691968
163response to pheromone (GO:0019236)2.12585664
164cellular response to leptin stimulus (GO:0044320)2.12452074
165cerebral cortex radially oriented cell migration (GO:0021799)2.12069041
166negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.08320967
167cytoskeleton-dependent intracellular transport (GO:0030705)2.08304161
168melanosome localization (GO:0032400)2.06820393
169isoprenoid biosynthetic process (GO:0008299)2.06766279
170regulation of development, heterochronic (GO:0040034)2.06491825
171regulation of dendritic spine morphogenesis (GO:0061001)2.06369584
172mitochondrion transport along microtubule (GO:0047497)2.05548960
173establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.05548960
174epithelial cilium movement (GO:0003351)2.04137500
175single-organism carbohydrate catabolic process (GO:0044724)2.03983390
176maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.03965308
177neuromuscular synaptic transmission (GO:0007274)2.03836796
178synaptic vesicle exocytosis (GO:0016079)2.03024358
179sequestering of actin monomers (GO:0042989)2.01496311
180ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.01329814
181membrane budding (GO:0006900)2.00706440
182L-glutamate transport (GO:0015813)2.00305598
183pigment granule localization (GO:0051875)1.99501851
184inner ear receptor stereocilium organization (GO:0060122)1.99357518
185cilium assembly (GO:0042384)1.97175547
186negative regulation of fatty acid biosynthetic process (GO:0045717)1.96968878
187microtubule-based transport (GO:0010970)1.96493783

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.00317075
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.46558379
3* RXR_22158963_ChIP-Seq_LIVER_Mouse4.70123702
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.85604583
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.64906380
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.55412171
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.49591405
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.46735195
9EGR1_23403033_ChIP-Seq_LIVER_Mouse3.25640349
10EZH2_22144423_ChIP-Seq_EOC_Human3.25298082
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.13262159
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.91527101
13ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.73103755
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.56743483
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.45321165
16IGF1R_20145208_ChIP-Seq_DFB_Human2.27728500
17GBX2_23144817_ChIP-Seq_PC3_Human2.26244245
18CLOCK_20551151_ChIP-Seq_293T_Human2.21275933
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.19228838
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.83586341
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77687829
22TAF15_26573619_Chip-Seq_HEK293_Human1.77200659
23HTT_18923047_ChIP-ChIP_STHdh_Human1.60603149
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60085556
25HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.56304989
26RNF2_27304074_Chip-Seq_NSC_Mouse1.50933459
27ZNF263_19887448_ChIP-Seq_K562_Human1.46647656
28WT1_19549856_ChIP-ChIP_CCG9911_Human1.46084231
29IRF1_19129219_ChIP-ChIP_H3396_Human1.44719165
30FUS_26573619_Chip-Seq_HEK293_Human1.43982117
31CREB1_15753290_ChIP-ChIP_HEK293T_Human1.31359830
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29744655
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.29455416
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.28268365
35SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.26702978
36EWS_26573619_Chip-Seq_HEK293_Human1.26229938
37TRIM28_21343339_ChIP-Seq_HEK293_Human1.23032095
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.22093415
39NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.21659633
40TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.20155566
41PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.19822639
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.19657519
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19390378
44NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18434029
45NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18434029
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.18146226
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16421371
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16241304
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16110576
50HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12603233
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11949013
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10402826
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.09620036
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.09420512
55SOX9_26525672_Chip-Seq_HEART_Mouse1.08724281
56GATA1_22025678_ChIP-Seq_K562_Human1.08645519
57KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08119093
58SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.07230244
59JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.07195916
60TBX3_20139965_ChIP-Seq_ESCs_Mouse1.06987016
61AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06750996
62HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06542868
63TBX3_20139965_ChIP-Seq_MESCs_Mouse1.06268103
64SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.06122105
65ELK1_19687146_ChIP-ChIP_HELA_Human1.05991361
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05160987
67THAP11_20581084_ChIP-Seq_MESCs_Mouse1.04537720
68* SMAD3_21741376_ChIP-Seq_EPCs_Human1.03922341
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03900721
70EED_16625203_ChIP-ChIP_MESCs_Mouse1.02887352
71EZH2_27304074_Chip-Seq_ESCs_Mouse1.02178130
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01383533
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01049371
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00437928
75NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99251821
76TP53_16413492_ChIP-PET_HCT116_Human0.99065524
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98622165
78NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98523297
79ER_23166858_ChIP-Seq_MCF-7_Human0.97513504
80TP53_18474530_ChIP-ChIP_U2OS_Human0.97270945
81VDR_22108803_ChIP-Seq_LS180_Human0.97001392
82P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94990845
83MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.94968381
84NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94460137
85EP300_21415370_ChIP-Seq_HL-1_Mouse0.94259449
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94218974
87ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93640455
88P300_19829295_ChIP-Seq_ESCs_Human0.91730332
89STAT3_23295773_ChIP-Seq_U87_Human0.91031032
90TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90454645
91REST_19997604_ChIP-ChIP_NEURONS_Mouse0.90449944
92* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.90244491
93SMAD4_21799915_ChIP-Seq_A2780_Human0.90207398
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88804742
95* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.87772644
96SOX2_16153702_ChIP-ChIP_HESCs_Human0.87708162
97GATA1_26923725_Chip-Seq_HPCs_Mouse0.87445736
98NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87233420
99SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.87012013
100FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.86534009
101SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.86375130
102GABP_17652178_ChIP-ChIP_JURKAT_Human0.86277609
103RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85272490
104* GABP_19822575_ChIP-Seq_HepG2_Human0.84981604
105* RUNX2_22187159_ChIP-Seq_PCA_Human0.84638112
106* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.84088571
107TOP2B_26459242_ChIP-Seq_MCF-7_Human0.84069416
108JUN_21703547_ChIP-Seq_K562_Human0.84058268
109RARG_19884340_ChIP-ChIP_MEFs_Mouse0.83465766
110NANOG_19829295_ChIP-Seq_ESCs_Human0.83390274
111SOX2_19829295_ChIP-Seq_ESCs_Human0.83390274
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82760655
113PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.82538179
114RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.81643495
115TAL1_26923725_Chip-Seq_HPCs_Mouse0.81036034
116* REST_18959480_ChIP-ChIP_MESCs_Mouse0.80892055
117AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.79451314
118BMI1_23680149_ChIP-Seq_NPCS_Mouse0.79330777
119CDX2_19796622_ChIP-Seq_MESCs_Mouse0.78946622
120PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.78856514
121RBPJ_22232070_ChIP-Seq_NCS_Mouse0.78576464
122KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78340127
123HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.77924872
124EOMES_21245162_ChIP-Seq_HESCs_Human0.76511614
125* HNF4A_19822575_ChIP-Seq_HepG2_Human0.76247863
126* SOX2_21211035_ChIP-Seq_LN229_Gbm0.76134187
127* CBP_21632823_ChIP-Seq_H3396_Human0.75508536
128AR_25329375_ChIP-Seq_VCAP_Human0.74912258
129OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.73256990
130FOXH1_21741376_ChIP-Seq_EPCs_Human0.73096420
131BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.71319866
132SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.71046230
133EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.70347163
134FOXH1_21741376_ChIP-Seq_ESCs_Human0.70043656
135NCOR_22424771_ChIP-Seq_293T_Human0.69716602
136STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.69490781
137* FOXA2_19822575_ChIP-Seq_HepG2_Human0.69263823
138TCF4_22108803_ChIP-Seq_LS180_Human0.69232043
139GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.68689611
140REST_21632747_ChIP-Seq_MESCs_Mouse0.68445468
141GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.68317575
142BCAT_22108803_ChIP-Seq_LS180_Human0.67967296
143PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.66238274
144PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.66221385
145ZNF274_21170338_ChIP-Seq_K562_Hela0.65971207
146SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.62999980
147FLI1_27457419_Chip-Seq_LIVER_Mouse0.62071780
148FLI1_21867929_ChIP-Seq_TH2_Mouse0.61148362
149CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.61105051
150POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.60605761
151KLF5_20875108_ChIP-Seq_MESCs_Mouse0.60038510
152PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.59987189
153CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.59846734

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.03048801
2MP0005360_urolithiasis4.05668829
3MP0002837_dystrophic_cardiac_calcinosis3.85034633
4MP0005365_abnormal_bile_salt3.83402953
5MP0005085_abnormal_gallbladder_physiolo3.65384893
6MP0003880_abnormal_central_pattern3.36917259
7MP0003122_maternal_imprinting3.26698893
8MP0008875_abnormal_xenobiotic_pharmacok3.23816152
9MP0005670_abnormal_white_adipose3.10559445
10MP0010329_abnormal_lipoprotein_level2.93278077
11MP0003195_calcinosis2.90017806
12MP0003806_abnormal_nucleotide_metabolis2.82037558
13MP0003136_yellow_coat_color2.62870501
14MP0004859_abnormal_synaptic_plasticity2.61068770
15MP0004130_abnormal_muscle_cell2.59079301
16MP0003646_muscle_fatigue2.56512755
17MP0005332_abnormal_amino_acid2.55491055
18MP0002876_abnormal_thyroid_physiology2.36547068
19MP0004084_abnormal_cardiac_muscle2.16805742
20MP0004036_abnormal_muscle_relaxation2.05847974
21MP0009840_abnormal_foam_cell2.02221003
22MP0006036_abnormal_mitochondrial_physio1.98710656
23MP0000778_abnormal_nervous_system1.96124125
24MP0005499_abnormal_olfactory_system1.89426040
25MP0005394_taste/olfaction_phenotype1.89426040
26MP0002118_abnormal_lipid_homeostasis1.87182825
27MP0001764_abnormal_homeostasis1.83205182
28MP0004133_heterotaxia1.79145642
29MP0005666_abnormal_adipose_tissue1.78009193
30MP0003121_genomic_imprinting1.72615974
31MP0000013_abnormal_adipose_tissue1.66650347
32MP0004272_abnormal_basement_membrane1.65135482
33MP0005423_abnormal_somatic_nervous1.57593808
34MP0003191_abnormal_cellular_cholesterol1.56475178
35MP0000749_muscle_degeneration1.55156647
36MP0005451_abnormal_body_composition1.52190979
37MP0005171_absent_coat_pigmentation1.51099951
38MP0009697_abnormal_copulation1.49656100
39MP0002938_white_spotting1.47563818
40MP0003890_abnormal_embryonic-extraembry1.44148089
41MP0006072_abnormal_retinal_apoptosis1.43546802
42MP0003186_abnormal_redox_activity1.42654739
43MP0009780_abnormal_chondrocyte_physiolo1.41359036
44MP0001661_extended_life_span1.40748392
45MP0004043_abnormal_pH_regulation1.40548889
46MP0004215_abnormal_myocardial_fiber1.40518185
47MP0005535_abnormal_body_temperature1.39675792
48MP0003635_abnormal_synaptic_transmissio1.38827270
49MP0005319_abnormal_enzyme/_coenzyme1.37934730
50MP0005187_abnormal_penis_morphology1.36914088
51MP0004019_abnormal_vitamin_homeostasis1.36471296
52MP0008789_abnormal_olfactory_epithelium1.36067672
53MP0002557_abnormal_social/conspecific_i1.35184830
54MP0000751_myopathy1.34867224
55MP0003252_abnormal_bile_duct1.34683639
56MP0008775_abnormal_heart_ventricle1.34485948
57MP0002909_abnormal_adrenal_gland1.34300393
58MP0000609_abnormal_liver_physiology1.32692147
59MP0003329_amyloid_beta_deposits1.32683622
60MP0005620_abnormal_muscle_contractility1.30995599
61MP0005248_abnormal_Harderian_gland1.30283615
62MP0002572_abnormal_emotion/affect_behav1.30279973
63MP0003567_abnormal_fetal_cardiomyocyte1.29697942
64MP0005083_abnormal_biliary_tract1.29554659
65MP0006138_congestive_heart_failure1.28861533
66MP0002063_abnormal_learning/memory/cond1.28519539
67MP0006035_abnormal_mitochondrial_morpho1.28411426
68MP0002971_abnormal_brown_adipose1.27848167
69MP0005584_abnormal_enzyme/coenzyme_acti1.27388520
70MP0002653_abnormal_ependyma_morphology1.26869644
71MP0001299_abnormal_eye_distance/1.26376144
72MP0008260_abnormal_autophagy1.26142373
73MP0005551_abnormal_eye_electrophysiolog1.24777409
74MP0000955_abnormal_spinal_cord1.24286070
75MP0002972_abnormal_cardiac_muscle1.24004516
76MP0004185_abnormal_adipocyte_glucose1.23061567
77MP0002184_abnormal_innervation1.23023755
78MP0005330_cardiomyopathy1.22823048
79MP0009745_abnormal_behavioral_response1.21787274
80MP0000647_abnormal_sebaceous_gland1.20920479
81MP0010030_abnormal_orbit_morphology1.16193798
82MP0002269_muscular_atrophy1.15687569
83MP0002102_abnormal_ear_morphology1.15065249
84MP0006292_abnormal_olfactory_placode1.14920818
85MP0001486_abnormal_startle_reflex1.13896143
86MP0002078_abnormal_glucose_homeostasis1.13436305
87MP0002234_abnormal_pharynx_morphology1.13278201
88MP0005253_abnormal_eye_physiology1.11938591
89MP0002332_abnormal_exercise_endurance1.11389659
90MP0004811_abnormal_neuron_physiology1.09871314
91MP0005375_adipose_tissue_phenotype1.08953096
92MP0000230_abnormal_systemic_arterial1.08941009
93MP0005334_abnormal_fat_pad1.08727002
94MP0000566_synostosis1.07807432
95MP0000604_amyloidosis1.06842100
96MP0001544_abnormal_cardiovascular_syste1.06595355
97MP0005385_cardiovascular_system_phenoty1.06595355
98MP0002090_abnormal_vision1.06011672
99MP0002233_abnormal_nose_morphology1.05892950
100MP0002882_abnormal_neuron_morphology1.05358740
101MP0003937_abnormal_limbs/digits/tail_de1.05123606
102MP0001968_abnormal_touch/_nociception1.05019278
103MP0006054_spinal_hemorrhage1.03918738
104MP0000747_muscle_weakness1.03616296
105MP0001542_abnormal_bone_strength1.02804954
106MP0003656_abnormal_erythrocyte_physiolo1.01978772
107MP0004145_abnormal_muscle_electrophysio1.01855793
108MP0001293_anophthalmia1.01536858
109MP0002736_abnormal_nociception_after1.01506464
110MP0001756_abnormal_urination1.00798880
111* MP0003221_abnormal_cardiomyocyte_apopto1.00711023
112MP0001666_abnormal_nutrient_absorption0.99722260
113MP0002734_abnormal_mechanical_nocicepti0.98981974
114MP0003718_maternal_effect0.96710429
115MP0002152_abnormal_brain_morphology0.96115081
116MP0002752_abnormal_somatic_nervous0.95372632
117MP0005376_homeostasis/metabolism_phenot0.95171297
118MP0001529_abnormal_vocalization0.93958937
119MP0002067_abnormal_sensory_capabilities0.93800416
120MP0005257_abnormal_intraocular_pressure0.93681327
121MP0002751_abnormal_autonomic_nervous0.93349124
122MP0000639_abnormal_adrenal_gland0.92123490
123MP0000026_abnormal_inner_ear0.91976059
124MP0003942_abnormal_urinary_system0.91703064
125MP0006276_abnormal_autonomic_nervous0.91545291
126MP0003011_delayed_dark_adaptation0.91007531
127MP0009046_muscle_twitch0.90920790
128MP0004142_abnormal_muscle_tone0.90906845
129MP0001501_abnormal_sleep_pattern0.89639841
130MP0002822_catalepsy0.89421888
131MP0002638_abnormal_pupillary_reflex0.89322298
132MP0000631_abnormal_neuroendocrine_gland0.89111096
133MP0004085_abnormal_heartbeat0.88906645
134MP0009643_abnormal_urine_homeostasis0.88403265
135MP0000049_abnormal_middle_ear0.88322768
136MP0004087_abnormal_muscle_fiber0.87818263
137MP0005448_abnormal_energy_balance0.87222680
138MP0003861_abnormal_nervous_system0.86998459
139MP0003137_abnormal_impulse_conducting0.86269254
140MP0005266_abnormal_metabolism0.86126204
141MP0001502_abnormal_circadian_rhythm0.86051695
142MP0001286_abnormal_eye_development0.85662072
143MP0004270_analgesia0.84878326
144MP0004858_abnormal_nervous_system0.83386367
145MP0003690_abnormal_glial_cell0.80820717
146MP0005408_hypopigmentation0.80343809
147MP0005195_abnormal_posterior_eye0.79234052
148MP0002697_abnormal_eye_size0.79197768
149MP0005645_abnormal_hypothalamus_physiol0.78809045
150MP0003119_abnormal_digestive_system0.78388283
151MP0005084_abnormal_gallbladder_morpholo0.78377508
152MP0002064_seizures0.77941894
153MP0002106_abnormal_muscle_physiology0.77907017
154MP0002066_abnormal_motor_capabilities/c0.76594538
155MP0003385_abnormal_body_wall0.75550542
156MP0000372_irregular_coat_pigmentation0.75062130
157MP0003787_abnormal_imprinting0.74588885
158MP0005391_vision/eye_phenotype0.73800915
159MP0003123_paternal_imprinting0.73148984
160MP0004233_abnormal_muscle_weight0.73129816
161MP0003755_abnormal_palate_morphology0.73066439
162MP0003879_abnormal_hair_cell0.72767953
163MP0001970_abnormal_pain_threshold0.72149727
164MP0002735_abnormal_chemical_nociception0.71686982
165MP0005636_abnormal_mineral_homeostasis0.70863318
166MP0003953_abnormal_hormone_level0.69866754
167MP0001440_abnormal_grooming_behavior0.69847480
168MP0005369_muscle_phenotype0.69160488
169MP0002272_abnormal_nervous_system0.67431184
170MP0009115_abnormal_fat_cell0.66782282
171MP0001984_abnormal_olfaction0.66717257
172MP0005452_abnormal_adipose_tissue0.65884911
173* MP0004484_altered_response_of0.65179864
174MP0005386_behavior/neurological_phenoty0.64259242
175MP0004924_abnormal_behavior0.64259242

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinemia (HP:0002154)4.32398380
2Increased serum pyruvate (HP:0003542)4.30113460
3Abnormality of glycolysis (HP:0004366)4.30113460
4Hyperglycinuria (HP:0003108)4.26426511
5Abnormality of aromatic amino acid family metabolism (HP:0004338)4.06565330
6Abnormality of serine family amino acid metabolism (HP:0010894)3.95438575
7Abnormality of glycine metabolism (HP:0010895)3.95438575
8Xanthomatosis (HP:0000991)3.92255738
9Abnormal gallbladder physiology (HP:0012438)3.79777000
10Cholecystitis (HP:0001082)3.79777000
11Oligomenorrhea (HP:0000876)3.63442697
12Myoglobinuria (HP:0002913)3.58797505
13Exercise-induced muscle cramps (HP:0003710)3.56649196
14Hyperlipoproteinemia (HP:0010980)3.54123930
15Gout (HP:0001997)3.46819975
16Abnormality of fatty-acid metabolism (HP:0004359)3.42027374
17Polyphagia (HP:0002591)3.39854982
18Cerebral edema (HP:0002181)3.37773363
19Hypoalphalipoproteinemia (HP:0003233)3.33819399
20Hyperammonemia (HP:0001987)3.33275737
21Pheochromocytoma (HP:0002666)3.32710250
22Deep venous thrombosis (HP:0002625)3.30139728
23Ketosis (HP:0001946)3.25674934
24Gait imbalance (HP:0002141)3.24004718
25Hypoglycemic coma (HP:0001325)3.17541372
26Hypobetalipoproteinemia (HP:0003563)3.16925261
27Intrahepatic cholestasis (HP:0001406)3.16004050
28Acute encephalopathy (HP:0006846)3.13877615
29Hypolipoproteinemia (HP:0010981)3.12489698
30Congenital primary aphakia (HP:0007707)3.10741479
31Abnormal mitochondria in muscle tissue (HP:0008316)3.08393279
32Acute necrotizing encephalopathy (HP:0006965)3.02918727
33Abnormality of serum amino acid levels (HP:0003112)3.02201332
34Neuroendocrine neoplasm (HP:0100634)3.01739868
35Hepatic necrosis (HP:0002605)3.01539954
36Medial flaring of the eyebrow (HP:0010747)3.00480800
37Lethargy (HP:0001254)2.99837356
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.99453597
39Abnormality of monocarboxylic acid metabolism (HP:0010996)2.95016802
40Rhabdomyolysis (HP:0003201)2.92811404
41Complement deficiency (HP:0004431)2.91277502
42Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.90787141
43Nephrogenic diabetes insipidus (HP:0009806)2.87367369
44Ketoacidosis (HP:0001993)2.84792195
45Cortical dysplasia (HP:0002539)2.81442885
46Abnormality of dicarboxylic acid metabolism (HP:0010995)2.77843248
47Dicarboxylic aciduria (HP:0003215)2.77843248
48Epidermoid cyst (HP:0200040)2.73616320
49Exercise-induced myalgia (HP:0003738)2.65391417
50Prolonged partial thromboplastin time (HP:0003645)2.65083779
51Hyperglycemia (HP:0003074)2.64785922
52True hermaphroditism (HP:0010459)2.63246852
53Progressive macrocephaly (HP:0004481)2.61374519
54Hyperuricemia (HP:0002149)2.59888551
55Increased purine levels (HP:0004368)2.59888551
56Hepatocellular necrosis (HP:0001404)2.59452486
57Abnormal gallbladder morphology (HP:0012437)2.58292438
58Abnormality of glutamine family amino acid metabolism (HP:0010902)2.49232177
59Cholelithiasis (HP:0001081)2.48759883
60Vaginal atresia (HP:0000148)2.45047658
61Genital tract atresia (HP:0001827)2.40473240
62Increased CSF lactate (HP:0002490)2.37128251
63Broad foot (HP:0001769)2.36697759
64Abnormality of purine metabolism (HP:0004352)2.35955413
65Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.34860178
66Abnormality of alanine metabolism (HP:0010916)2.34860178
67Hyperalaninemia (HP:0003348)2.34860178
68Mitochondrial inheritance (HP:0001427)2.32724998
69Metabolic acidosis (HP:0001942)2.31946412
70Generalized aminoaciduria (HP:0002909)2.30274223
71Lactic acidosis (HP:0003128)2.30223579
72Myokymia (HP:0002411)2.29959968
73Abnormality of aspartate family amino acid metabolism (HP:0010899)2.27511615
74Nausea (HP:0002018)2.26463644
75Skin nodule (HP:0200036)2.24272772
76Pancreatic fibrosis (HP:0100732)2.24188036
77Abnormality of methionine metabolism (HP:0010901)2.23925454
78Palpitations (HP:0001962)2.23764442
79Neoplasm of the adrenal gland (HP:0100631)2.20359539
80CNS demyelination (HP:0007305)2.17239553
81Insulin-resistant diabetes mellitus (HP:0000831)2.16016968
82Brushfield spots (HP:0001088)2.14914136
83Vomiting (HP:0002013)2.14879087
84Supernumerary spleens (HP:0009799)2.12540367
85Focal motor seizures (HP:0011153)2.10994873
86Hypoplastic pelvis (HP:0008839)2.10613808
87Hyperventilation (HP:0002883)2.09966348
88Muscle fiber splitting (HP:0003555)2.08097900
89Specific learning disability (HP:0001328)2.07407787
90Poor coordination (HP:0002370)2.05400395
91Methylmalonic aciduria (HP:0012120)2.04630950
92Retinal dysplasia (HP:0007973)2.04081970
93Abnormal eating behavior (HP:0100738)2.02261793
94Abnormality of nucleobase metabolism (HP:0010932)1.99172765
95Abnormality of sulfur amino acid metabolism (HP:0004339)1.99045431
96Hemiparesis (HP:0001269)1.97378737
97Pancreatic cysts (HP:0001737)1.96772542
98Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.95640269
99Exercise intolerance (HP:0003546)1.95193392
100Proximal tubulopathy (HP:0000114)1.94797860
101Hepatoblastoma (HP:0002884)1.94618737
102Irritability (HP:0000737)1.94161000
103Increased muscle lipid content (HP:0009058)1.93322525
104Cerebral hemorrhage (HP:0001342)1.92533865
105Reticulocytosis (HP:0001923)1.91132367
106Postaxial foot polydactyly (HP:0001830)1.90651092
107Abnormality of the gallbladder (HP:0005264)1.88557907
108Decreased testicular size (HP:0008734)1.86826825
109Postaxial hand polydactyly (HP:0001162)1.86585602
110Fat malabsorption (HP:0002630)1.85104267
111Aplasia/Hypoplasia of the tongue (HP:0010295)1.84686332
112Muscle hypertrophy of the lower extremities (HP:0008968)1.84068185
113Hydroxyprolinuria (HP:0003080)1.82788992
114Abnormality of proline metabolism (HP:0010907)1.82788992
115Hand muscle atrophy (HP:0009130)1.82736128
116Poor suck (HP:0002033)1.81848948
117Abnormality of the intrinsic pathway (HP:0010989)1.81640617
118Conjunctival hamartoma (HP:0100780)1.81395291
119Abnormality of the common coagulation pathway (HP:0010990)1.80971458
120Molar tooth sign on MRI (HP:0002419)1.80432819
121Abnormality of midbrain morphology (HP:0002418)1.80432819
122Occipital encephalocele (HP:0002085)1.79138154
123Respiratory failure (HP:0002878)1.78461627
124Calf muscle hypertrophy (HP:0008981)1.78312251
125Postnatal microcephaly (HP:0005484)1.77335869
126Short tibia (HP:0005736)1.77127106
127Irregular epiphyses (HP:0010582)1.76912156
128Muscle stiffness (HP:0003552)1.76373766
129Abnormality of complement system (HP:0005339)1.75583470
130Atonic seizures (HP:0010819)1.74571425
131Epiphyseal stippling (HP:0010655)1.73738266
132Chronic hepatic failure (HP:0100626)1.72847671
133Increased serum lactate (HP:0002151)1.72720014
134Lissencephaly (HP:0001339)1.72590487
135Myelomeningocele (HP:0002475)1.71708423
136Abnormal cartilage morphology (HP:0002763)1.70816252
137Left ventricular hypertrophy (HP:0001712)1.70386772
138Tetraplegia (HP:0002445)1.68709458
139Glycosuria (HP:0003076)1.67380762
140Sclerocornea (HP:0000647)1.66080412
141Hypsarrhythmia (HP:0002521)1.65784357
142Renal hypoplasia (HP:0000089)1.65608711
143Amblyopia (HP:0000646)1.63817914
144Aplasia/Hypoplasia of the lens (HP:0008063)1.63018035
145Adrenal hypoplasia (HP:0000835)1.61643826
146Micropenis (HP:0000054)1.61616849
147Aplasia/Hypoplasia of the tibia (HP:0005772)1.61437132
148Aplasia/Hypoplasia of the brainstem (HP:0007362)1.61140389
149Hypoplasia of the brainstem (HP:0002365)1.61140389
150Upper limb muscle weakness (HP:0003484)1.61130273
151Drooling (HP:0002307)1.60939444
152EEG with generalized epileptiform discharges (HP:0011198)1.59978800
153Double outlet right ventricle (HP:0001719)1.59399606
154Congenital malformation of the right heart (HP:0011723)1.59399606
155Bifid tongue (HP:0010297)1.59020906
156Humeroradial synostosis (HP:0003041)1.57958575
157Synostosis involving the elbow (HP:0003938)1.57958575
158Epileptiform EEG discharges (HP:0011182)1.57842344
159Intestinal atresia (HP:0011100)1.57575143
160Anophthalmia (HP:0000528)1.55344433
161Muscular hypotonia of the trunk (HP:0008936)1.53801709
162Labial hypoplasia (HP:0000066)1.53682741
163Nephronophthisis (HP:0000090)1.52565138
164Hammertoe (HP:0001765)1.51824595
165Abnormality of the musculature of the pelvis (HP:0001469)1.51688326
166Abnormality of the hip-girdle musculature (HP:0001445)1.51688326
167Coronal craniosynostosis (HP:0004440)1.51191900
168Cystic liver disease (HP:0006706)1.50968351
169Oligodactyly (hands) (HP:0001180)1.50009920
170Optic nerve hypoplasia (HP:0000609)1.49878703
171Abnormality of abdominal situs (HP:0011620)1.49388275
172Abdominal situs inversus (HP:0003363)1.49388275
173Failure to thrive in infancy (HP:0001531)1.48931402
174Abnormality of the labia minora (HP:0012880)1.47310629
175Spastic tetraplegia (HP:0002510)1.46912251

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.85126786
2OBSCN3.66188426
3MAP4K23.30048331
4PDK33.16051351
5PDK43.16051351
6CASK3.14825388
7AKT33.03028565
8MARK12.84348317
9STK38L2.62410498
10ARAF2.62203169
11NEK12.54457958
12PINK12.32391355
13PDK22.27376235
14NME12.12248176
15TRIM282.01205976
16MAP2K41.96614753
17PKN21.92249843
18MAP3K41.81211862
19NTRK21.80782542
20INSRR1.79575856
21CSNK1A1L1.52143364
22STK241.46740623
23MAP3K91.46722606
24PLK21.44930744
25DYRK21.43590350
26MYLK1.42751585
27TSSK61.41582685
28BCR1.40278277
29OXSR11.38134981
30PHKG11.37763471
31PHKG21.37763471
32FLT31.37539219
33TNIK1.32956822
34EPHA31.32706037
35MAP2K71.31768199
36MST1R1.27401772
37TESK11.27275155
38BRAF1.26451539
39CSNK1G11.24635669
40MOS1.18493523
41DAPK21.16091747
42GRK51.14963322
43SRPK11.11774534
44RPS6KA41.11636893
45ERBB31.10855413
46SGK4941.09368842
47SGK2231.09368842
48MAPK131.08535428
49FRK1.08131509
50WNK31.04997339
51KSR21.03058703
52DYRK1B1.01664315
53NEK91.00602224
54MAP2K11.00554773
55CCNB10.99606444
56PIK3CA0.99478488
57SIK10.98039768
58ERBB40.96381362
59LATS20.95783443
60MINK10.95319577
61EPHB20.94822270
62PRKCG0.94520970
63DYRK30.94488626
64PIM20.93922975
65PRKD30.89727519
66BRSK20.89301088
67SGK20.88967275
68CAMKK20.88178579
69UHMK10.86796610
70ZAK0.85001807
71MAP3K30.83962507
72BMPR1B0.82164430
73PRPF4B0.82059296
74CDK140.81954914
75CAMK2G0.81810424
76PLK30.81304165
77EPHB10.81067547
78STK160.80591106
79CDK180.80500701
80MAP3K120.80142176
81EIF2AK10.78871413
82LIMK10.77224274
83PRKAA10.76560191
84MET0.74726119
85CDK150.72376039
86CDK11A0.71217377
87STK390.71177718
88NTRK30.69576405
89PRKCE0.69531900
90KSR10.69342502
91EPHA20.68530359
92WNK40.65698265
93LMTK20.65083021
94PIK3CG0.64597665
95FER0.64574164
96CDK50.63975194
97CAMK2D0.63679443
98EIF2AK30.62904231
99FGFR10.62382867
100ABL20.61671538
101BUB10.61667900
102PDPK10.61477967
103PBK0.60593618
104ACVR1B0.60109719
105SGK30.58808324
106PRKAA20.58796088
107LATS10.56128225
108CAMK2A0.55421612
109DAPK30.53097068
110NEK20.52566139
111BRSK10.52038857
112NTRK10.50487591
113MAPK120.50411309
114TESK20.49595733
115CAMK1D0.48338812
116PRKACG0.48061035
117AKT20.47682512
118CAMK40.46622616
119MAP3K20.46513572
120ROCK20.45915836
121PDK10.45828724
122EPHA40.45807535
123PRKACA0.45794484
124CAMK2B0.44764264
125GRK10.44426684
126PAK60.43342451
127DYRK1A0.40066687
128CDK190.39580357
129GRK70.39278261
130PLK10.39103062
131TRIB30.38093041
132SIK30.36864658
133PAK30.36463840
134WEE10.36165582
135CSNK1G20.35429481
136NEK60.35412625
137MAPKAPK50.34654643
138RET0.33811975
139PKN10.33724279
140FGFR40.33596019
141CSNK1G30.33438060
142RAF10.33418174
143ERBB20.32096436

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.17327121
2Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.92681123
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.83407029
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.83098630
5Propanoate metabolism_Homo sapiens_hsa006402.82768586
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.64239296
7Vitamin B6 metabolism_Homo sapiens_hsa007502.49672381
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.44819675
9Butanoate metabolism_Homo sapiens_hsa006502.35816431
10Pyruvate metabolism_Homo sapiens_hsa006202.32453029
11Fatty acid degradation_Homo sapiens_hsa000712.26635226
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.17821636
13Carbon metabolism_Homo sapiens_hsa012002.17031227
14Arginine biosynthesis_Homo sapiens_hsa002202.15018199
15Fatty acid metabolism_Homo sapiens_hsa012122.14310729
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.13405423
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.00359028
18Biosynthesis of amino acids_Homo sapiens_hsa012301.88218523
19PPAR signaling pathway_Homo sapiens_hsa033201.83164016
20Fatty acid elongation_Homo sapiens_hsa000621.79049970
21Peroxisome_Homo sapiens_hsa041461.74165051
22Oxidative phosphorylation_Homo sapiens_hsa001901.69509583
23Tryptophan metabolism_Homo sapiens_hsa003801.69296170
24Nitrogen metabolism_Homo sapiens_hsa009101.62185103
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.58379519
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.58141375
27Phenylalanine metabolism_Homo sapiens_hsa003601.57619946
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.56049344
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.54912583
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.54072698
31beta-Alanine metabolism_Homo sapiens_hsa004101.51857317
32Tyrosine metabolism_Homo sapiens_hsa003501.46529248
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.36711051
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.36183286
35Complement and coagulation cascades_Homo sapiens_hsa046101.35444726
36Sulfur metabolism_Homo sapiens_hsa009201.35217261
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.31961250
38Fructose and mannose metabolism_Homo sapiens_hsa000511.27576698
39Parkinsons disease_Homo sapiens_hsa050121.26214979
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.26212121
41Collecting duct acid secretion_Homo sapiens_hsa049661.25945101
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24301682
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.16390137
44Pentose phosphate pathway_Homo sapiens_hsa000301.13799187
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.12343169
46Starch and sucrose metabolism_Homo sapiens_hsa005001.10923365
47Chemical carcinogenesis_Homo sapiens_hsa052041.06262019
48Steroid biosynthesis_Homo sapiens_hsa001001.04455582
49Glycerolipid metabolism_Homo sapiens_hsa005611.03265861
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02799057
51Drug metabolism - other enzymes_Homo sapiens_hsa009831.00330596
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.98135298
53Synaptic vesicle cycle_Homo sapiens_hsa047210.97795707
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92725930
55Fatty acid biosynthesis_Homo sapiens_hsa000610.92214026
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.89256776
57Arginine and proline metabolism_Homo sapiens_hsa003300.88581438
58Histidine metabolism_Homo sapiens_hsa003400.88111015
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86815484
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.86317745
61Alzheimers disease_Homo sapiens_hsa050100.86073884
62Cardiac muscle contraction_Homo sapiens_hsa042600.85564301
63Regulation of autophagy_Homo sapiens_hsa041400.84937468
64Phototransduction_Homo sapiens_hsa047440.84148743
65Retinol metabolism_Homo sapiens_hsa008300.82765302
66Fat digestion and absorption_Homo sapiens_hsa049750.81619445
67Caffeine metabolism_Homo sapiens_hsa002320.80973472
68Folate biosynthesis_Homo sapiens_hsa007900.80504496
69Cocaine addiction_Homo sapiens_hsa050300.78916130
70Galactose metabolism_Homo sapiens_hsa000520.78514692
71Axon guidance_Homo sapiens_hsa043600.77743497
72Dopaminergic synapse_Homo sapiens_hsa047280.77026429
73Huntingtons disease_Homo sapiens_hsa050160.72872948
74Glutamatergic synapse_Homo sapiens_hsa047240.71697703
75Bile secretion_Homo sapiens_hsa049760.71053963
76Metabolic pathways_Homo sapiens_hsa011000.70594309
77Proteasome_Homo sapiens_hsa030500.67617259
78Vibrio cholerae infection_Homo sapiens_hsa051100.66958246
79Insulin secretion_Homo sapiens_hsa049110.66899913
80Morphine addiction_Homo sapiens_hsa050320.65820905
81RNA degradation_Homo sapiens_hsa030180.63924724
82Hippo signaling pathway_Homo sapiens_hsa043900.63716605
83Glucagon signaling pathway_Homo sapiens_hsa049220.62720750
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.61624862
85Vitamin digestion and absorption_Homo sapiens_hsa049770.61241916
86Selenocompound metabolism_Homo sapiens_hsa004500.58934316
87Circadian entrainment_Homo sapiens_hsa047130.57453705
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57350188
89Glutathione metabolism_Homo sapiens_hsa004800.56380829
90Amphetamine addiction_Homo sapiens_hsa050310.56281628
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50216781
92Staphylococcus aureus infection_Homo sapiens_hsa051500.49920573
93AMPK signaling pathway_Homo sapiens_hsa041520.48854671
94Basal transcription factors_Homo sapiens_hsa030220.48039685
95Hedgehog signaling pathway_Homo sapiens_hsa043400.46369924
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45831541
97Taste transduction_Homo sapiens_hsa047420.44868859
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44838090
99Basal cell carcinoma_Homo sapiens_hsa052170.44610665
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44065611
101Lysine degradation_Homo sapiens_hsa003100.43467361
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.42481267
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41022213
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40050788
105Circadian rhythm_Homo sapiens_hsa047100.37553170
106Insulin signaling pathway_Homo sapiens_hsa049100.37393817
107Oocyte meiosis_Homo sapiens_hsa041140.37202825
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.36840831
109Gap junction_Homo sapiens_hsa045400.36378656
110GABAergic synapse_Homo sapiens_hsa047270.34446706
111Maturity onset diabetes of the young_Homo sapiens_hsa049500.34083455
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32810866
113Nicotine addiction_Homo sapiens_hsa050330.30998948
114ABC transporters_Homo sapiens_hsa020100.28977106
115Sulfur relay system_Homo sapiens_hsa041220.27405500
116Insulin resistance_Homo sapiens_hsa049310.26476373
117Cyanoamino acid metabolism_Homo sapiens_hsa004600.25268926
118HIF-1 signaling pathway_Homo sapiens_hsa040660.19109451
119Linoleic acid metabolism_Homo sapiens_hsa005910.18790284
120Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.16421483
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.15150121
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.15020200
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.14298748
124Protein export_Homo sapiens_hsa030600.13573089
125Dilated cardiomyopathy_Homo sapiens_hsa054140.11735245

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