BNIP3L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including loss of membrane potential and the release of cytochrome c. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)6.64774972
2microglial cell activation (GO:0001774)6.01313795
3long-chain fatty acid biosynthetic process (GO:0042759)5.87406615
4protein neddylation (GO:0045116)5.72301456
5myelin maintenance (GO:0043217)5.51270847
6protoporphyrinogen IX metabolic process (GO:0046501)5.49547859
7negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)5.44851851
8ensheathment of neurons (GO:0007272)5.35951098
9axon ensheathment (GO:0008366)5.35951098
10myelination (GO:0042552)5.35815582
11protoporphyrinogen IX biosynthetic process (GO:0006782)5.21445836
12positive regulation of gamma-delta T cell activation (GO:0046645)4.98725592
13phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.90125837
14regulation of B cell receptor signaling pathway (GO:0050855)4.59983424
15detection of molecule of bacterial origin (GO:0032490)4.49055000
16negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.48565149
17neural tube formation (GO:0001841)4.44594166
18regulation of collateral sprouting (GO:0048670)4.40918609
19hepatocyte apoptotic process (GO:0097284)4.40454933
20positive regulation of insulin receptor signaling pathway (GO:0046628)4.40162278
21response to methylmercury (GO:0051597)4.40064020
22neutrophil mediated immunity (GO:0002446)4.36660106
23negative regulation of neurotransmitter transport (GO:0051589)4.33230948
24positive regulation of response to oxidative stress (GO:1902884)4.30798791
25positive regulation of cellular response to oxidative stress (GO:1900409)4.30798791
26negative regulation of cell killing (GO:0031342)4.27884018
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.27884018
28histone mRNA catabolic process (GO:0071044)4.25972949
29myeloid leukocyte mediated immunity (GO:0002444)4.22467786
30protein targeting to Golgi (GO:0000042)4.21908967
31regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)4.19233632
32positive regulation of receptor recycling (GO:0001921)4.18877669
33establishment of protein localization to Golgi (GO:0072600)4.15274121
34positive regulation of inositol phosphate biosynthetic process (GO:0060732)4.11738724
35positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.10240169
36retrograde transport, vesicle recycling within Golgi (GO:0000301)4.04030271
37negative regulation of protein localization to cell surface (GO:2000009)4.01672468
38regulation of beta-amyloid formation (GO:1902003)3.98864928
39negative regulation of neurotransmitter secretion (GO:0046929)3.93277570
40microtubule polymerization or depolymerization (GO:0031109)3.81966965
41activated T cell proliferation (GO:0050798)3.79384312
42positive regulation of mitochondrial fission (GO:0090141)3.79092133
43regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.77202240
44macrophage activation (GO:0042116)3.72095037
45dopamine transport (GO:0015872)3.66935000
46regulation of inositol phosphate biosynthetic process (GO:0010919)3.65584286
47positive regulation of oligodendrocyte differentiation (GO:0048714)3.64192438
48presynaptic membrane organization (GO:0097090)3.63559999
49cellular response to epinephrine stimulus (GO:0071872)3.63519829
50oligodendrocyte differentiation (GO:0048709)3.62765155
51regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.60325302
52response to redox state (GO:0051775)3.58635701
53cholesterol biosynthetic process (GO:0006695)3.54836099
54chaperone-mediated protein transport (GO:0072321)3.53249415
55pyrimidine nucleobase catabolic process (GO:0006208)3.51368121
56apical protein localization (GO:0045176)3.48995397
57protein K48-linked deubiquitination (GO:0071108)3.48357878
58eye photoreceptor cell differentiation (GO:0001754)3.47960014
59photoreceptor cell differentiation (GO:0046530)3.47960014
60response to lead ion (GO:0010288)3.47364675
61positive regulation of granulocyte differentiation (GO:0030854)3.46875822
62histone H3-K36 demethylation (GO:0070544)3.45805891
63negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.41900909
64asymmetric protein localization (GO:0008105)3.41702360
65dosage compensation (GO:0007549)3.41572601
66substantia nigra development (GO:0021762)3.40875602
67cellular response to leptin stimulus (GO:0044320)3.38890964
68regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.38091568
69regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.38091568
70amyloid precursor protein metabolic process (GO:0042982)3.35850904
71modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.35196672
72positive regulation by organism of defense response of other organism involved in symbiotic interact3.35196672
73modulation by symbiont of host immune response (GO:0052553)3.35196672
74positive regulation by symbiont of host defense response (GO:0052509)3.35196672
75modulation by symbiont of host defense response (GO:0052031)3.35196672
76modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.35196672
77neurotransmitter uptake (GO:0001504)3.33609594
78isoprenoid biosynthetic process (GO:0008299)3.33268851
79regulation of mitochondrial depolarization (GO:0051900)3.32926768
80regulation of mitochondrial fission (GO:0090140)3.31184534
81creatine metabolic process (GO:0006600)3.30351445
82protein K63-linked deubiquitination (GO:0070536)3.30060904
83regulation of gamma-delta T cell activation (GO:0046643)3.29024555
84cerebral cortex radially oriented cell migration (GO:0021799)3.26861202
85peptidyl-cysteine modification (GO:0018198)3.26439803
86import into cell (GO:0098657)3.25108795
87positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.24298348
88proteasome assembly (GO:0043248)3.24006851
89negative regulation of T cell mediated immunity (GO:0002710)3.22279059
90negative regulation of B cell proliferation (GO:0030889)3.22116387
91negative regulation of B cell mediated immunity (GO:0002713)3.21888787
92negative regulation of immunoglobulin mediated immune response (GO:0002890)3.21888787
93regulation of gamma-delta T cell differentiation (GO:0045586)3.21212796
94monoubiquitinated protein deubiquitination (GO:0035520)3.21121670
95positive regulation of neurotransmitter secretion (GO:0001956)3.18992672
96presynaptic membrane assembly (GO:0097105)3.18845827
97response to insecticide (GO:0017085)3.18788878
98antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.17843170
99positive regulation of pseudopodium assembly (GO:0031274)3.15833159
100negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.15251015
101negative T cell selection (GO:0043383)3.15111161
102regulation of glutamate secretion (GO:0014048)3.15030217
103negative regulation of glial cell proliferation (GO:0060253)3.11051181
104histone H3-K9 demethylation (GO:0033169)3.10807140
105negative regulation of exocytosis (GO:0045920)3.10050198
106positive T cell selection (GO:0043368)3.09952927
107GPI anchor biosynthetic process (GO:0006506)3.05680541
108regulation of amyloid precursor protein catabolic process (GO:1902991)3.05633963
109dopamine biosynthetic process (GO:0042416)3.05469823
110olfactory bulb development (GO:0021772)3.04532783
111negative regulation of protein oligomerization (GO:0032460)3.03709221
112limb bud formation (GO:0060174)3.03334871
113astrocyte development (GO:0014002)3.03287128
114regulation of glial cell proliferation (GO:0060251)3.02932611
115negative regulation of lymphocyte mediated immunity (GO:0002707)3.02863098
116sterol biosynthetic process (GO:0016126)3.00294211
117negative regulation of complement activation (GO:0045916)2.99610166
118negative regulation of execution phase of apoptosis (GO:1900118)2.99542397
119glycosylceramide metabolic process (GO:0006677)2.97463217
120magnesium ion transport (GO:0015693)2.95342442
121regulation of protein glycosylation (GO:0060049)2.95331895
122negative thymic T cell selection (GO:0045060)2.95048681
123negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.94992179
124protein targeting to lysosome (GO:0006622)2.94929414
125establishment of protein localization to vacuole (GO:0072666)2.94929414
126protein targeting to vacuole (GO:0006623)2.94929414
127establishment of nucleus localization (GO:0040023)2.94744590
128tissue regeneration (GO:0042246)2.94416188
129heme biosynthetic process (GO:0006783)2.92518322
130establishment of mitochondrion localization (GO:0051654)2.92467566
131synaptic vesicle endocytosis (GO:0048488)2.92172000
132hemoglobin metabolic process (GO:0020027)2.91165830
133cellular extravasation (GO:0045123)2.90758545
134cytoplasmic mRNA processing body assembly (GO:0033962)2.89993096
135mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.89761815
136positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.88129156
137regulation of receptor recycling (GO:0001919)2.87808435
138protein localization to Golgi apparatus (GO:0034067)2.87719298
139histone H3-K4 trimethylation (GO:0080182)2.87587991
140cellular response to catecholamine stimulus (GO:0071870)2.85800905
141cellular response to monoamine stimulus (GO:0071868)2.85800905
142negative regulation of inclusion body assembly (GO:0090084)2.85770852
143histone H2B ubiquitination (GO:0033523)2.85273778
144phospholipid homeostasis (GO:0055091)2.84776105
145regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.84598338
146response to epinephrine (GO:0071871)2.84313499
147L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.82138390
148macroautophagy (GO:0016236)2.81356612
149regulation of cellular amide metabolic process (GO:0034248)2.80742519
150detection of external biotic stimulus (GO:0098581)2.78607252
151L-amino acid import (GO:0043092)2.77867008
152GPI anchor metabolic process (GO:0006505)2.77217447
153regulation of interleukin-13 production (GO:0032656)2.77115160
154macrophage activation involved in immune response (GO:0002281)2.77019112
155negative regulation of JUN kinase activity (GO:0043508)2.75917419
156preassembly of GPI anchor in ER membrane (GO:0016254)2.75903332
157membrane raft organization (GO:0031579)2.75276305
158porphyrin-containing compound biosynthetic process (GO:0006779)2.74382943
159cerebellar Purkinje cell differentiation (GO:0021702)2.73915472
160positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.73442083
161long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.72744149
162peptidyl-tyrosine autophosphorylation (GO:0038083)2.72220817
163cellular response to ethanol (GO:0071361)2.71785059
164leukocyte migration involved in inflammatory response (GO:0002523)2.70907003
165enteric nervous system development (GO:0048484)2.70733325
166* mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.68932429
167* positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.68932429
168virion attachment to host cell (GO:0019062)2.65211251
169adhesion of symbiont to host cell (GO:0044650)2.65211251
170protein K11-linked deubiquitination (GO:0035871)2.64708187
171regulation of pseudopodium assembly (GO:0031272)2.64161878
172response to lipoprotein particle (GO:0055094)2.62894866
173long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.62233441
174regulation of exit from mitosis (GO:0007096)2.60420185
175glial cell development (GO:0021782)2.59736728
176cellular response to gamma radiation (GO:0071480)2.59571923
177iron coordination entity transport (GO:1901678)2.56445048
178neurotransmitter catabolic process (GO:0042135)2.56294591
179glycerophospholipid catabolic process (GO:0046475)2.53608957
180lung-associated mesenchyme development (GO:0060484)2.53361269
181mesodermal cell differentiation (GO:0048333)2.52160851
182transcription elongation from RNA polymerase III promoter (GO:0006385)2.51453824
183termination of RNA polymerase III transcription (GO:0006386)2.51453824
184heme metabolic process (GO:0042168)2.50380873
185RNA capping (GO:0036260)2.46082688
1867-methylguanosine RNA capping (GO:0009452)2.46082688
187neutrophil activation involved in immune response (GO:0002283)2.44883291
1887-methylguanosine mRNA capping (GO:0006370)2.44393086
189membrane tubulation (GO:0097320)2.42071365
190negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.41226847
191oligodendrocyte development (GO:0014003)2.38954688
192positive regulation of actin filament depolymerization (GO:0030836)2.38462047
193tetrapyrrole biosynthetic process (GO:0033014)2.37651431
194axon development (GO:0061564)2.37157605
195negative regulation of acute inflammatory response (GO:0002674)2.36967937
196axon ensheathment in central nervous system (GO:0032291)10.0679994
197central nervous system myelination (GO:0022010)10.0679994

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.38062775
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.23553552
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.14464598
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.14596479
5SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.95165155
6TAF15_26573619_Chip-Seq_HEK293_Human2.78653528
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.55557621
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.50675745
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.50530014
10POU5F1_16153702_ChIP-ChIP_HESCs_Human2.49878676
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.47992011
12OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.41000060
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.37749902
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.35834295
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.22584708
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.20798262
17ER_23166858_ChIP-Seq_MCF-7_Human2.17113423
18* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.10422559
19* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.09013028
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.04739123
21GBX2_23144817_ChIP-Seq_PC3_Human1.97336233
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.96493106
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.92565969
24IGF1R_20145208_ChIP-Seq_DFB_Human1.91416173
25EWS_26573619_Chip-Seq_HEK293_Human1.89965035
26TP53_16413492_ChIP-PET_HCT116_Human1.89923024
27RUNX_20019798_ChIP-Seq_JUKART_Human1.88524671
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84770739
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.84215892
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.84074078
31* FUS_26573619_Chip-Seq_HEK293_Human1.83854874
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.83786553
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.82688740
34RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.76440686
35IRF8_22096565_ChIP-ChIP_GC-B_Human1.75581387
36KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.72069235
37GATA1_22025678_ChIP-Seq_K562_Human1.71958329
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.67481841
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65067321
40WT1_19549856_ChIP-ChIP_CCG9911_Human1.64297154
41IRF8_21731497_ChIP-ChIP_J774_Mouse1.61525493
42FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.60887732
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60688732
44P300_19829295_ChIP-Seq_ESCs_Human1.58213418
45IRF1_19129219_ChIP-ChIP_H3396_Human1.57840644
46IRF8_27001747_Chip-Seq_BMDM_Mouse1.54858762
47NRF2_20460467_ChIP-Seq_MEFs_Mouse1.54704329
48NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.54704329
49SCL_19346495_ChIP-Seq_HPC-7_Human1.54384636
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.54000282
51* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.53554737
52TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.52358851
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51679683
54* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49491148
55STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.46491323
56FLI1_21867929_ChIP-Seq_TH2_Mouse1.46419755
57SMAD4_21799915_ChIP-Seq_A2780_Human1.45217275
58CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.42924920
59VDR_24787735_ChIP-Seq_THP-1_Human1.42244612
60CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.40371908
61VDR_22108803_ChIP-Seq_LS180_Human1.39459128
62* STAT3_23295773_ChIP-Seq_U87_Human1.38886584
63BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38602620
64MYB_21317192_ChIP-Seq_ERMYB_Mouse1.37156138
65ELK1_19687146_ChIP-ChIP_HELA_Human1.36618808
66RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.36530395
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36365086
68TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.36069959
69PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35650878
70AR_21572438_ChIP-Seq_LNCaP_Human1.35308876
71* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34986901
72IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.33448537
73EED_16625203_ChIP-ChIP_MESCs_Mouse1.33331620
74EOMES_21245162_ChIP-Seq_HESCs_Human1.30758028
75SOX17_20123909_ChIP-Seq_XEN_Mouse1.28010997
76SOX2_16153702_ChIP-ChIP_HESCs_Human1.27438673
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26307383
78SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.26182964
79* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.24843707
80NFE2_27457419_Chip-Seq_LIVER_Mouse1.24600214
81PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24542361
82SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.24091544
83TCF4_23295773_ChIP-Seq_U87_Human1.23610240
84TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.22878313
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22848219
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22848219
87VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21644811
88IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.21256703
89PIAS1_25552417_ChIP-Seq_VCAP_Human1.21229333
90FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.21110555
91RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.20562511
92CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20551869
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19506494
94P53_22387025_ChIP-Seq_ESCs_Mouse1.19400371
95OCT4_21477851_ChIP-Seq_ESCs_Mouse1.19255638
96NANOG_19829295_ChIP-Seq_ESCs_Human1.19209329
97SOX2_19829295_ChIP-Seq_ESCs_Human1.19209329
98STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.19024672
99CBX2_27304074_Chip-Seq_ESCs_Mouse1.18330122
100E2F1_18555785_Chip-Seq_ESCs_Mouse1.17830985
101CRX_20693478_ChIP-Seq_RETINA_Mouse1.17053539
102HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16797889
103* GATA1_19941826_ChIP-Seq_K562_Human1.16684042
104RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13913454
105SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13754574
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13495821
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13022770
108AR_25329375_ChIP-Seq_VCAP_Human1.12946396
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12089137
110ZNF274_21170338_ChIP-Seq_K562_Hela1.10452470
111* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10132190
112* CBP_20019798_ChIP-Seq_JUKART_Human1.10132190
113SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09895283
114NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09883662
115SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.09759270
116* GATA2_19941826_ChIP-Seq_K562_Human1.09708881
117CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08418367
118GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08062242
119* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08030938
120SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07728286
121SRF_21415370_ChIP-Seq_HL-1_Mouse1.07704462
122RUNX2_22187159_ChIP-Seq_PCA_Human1.07615074
123TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07306020
124* MYB_26560356_Chip-Seq_TH2_Human1.07144478
125CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07050277
126TAL1_26923725_Chip-Seq_HPCs_Mouse1.06530934
127JARID2_20064375_ChIP-Seq_MESCs_Mouse1.06177901
128SMAD3_21741376_ChIP-Seq_EPCs_Human1.05854139
129FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.05706257
130EZH2_27304074_Chip-Seq_ESCs_Mouse1.05081356
131P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05069147
132GATA3_27048872_Chip-Seq_THYMUS_Human1.04875382
133HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03750188
134EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03591868
135ETS1_20019798_ChIP-Seq_JURKAT_Human1.03506358
136LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02906830
137RNF2_27304074_Chip-Seq_NSC_Mouse1.01086044
138SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.01082384
139GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00742382
140SALL4_22934838_ChIP-ChIP_CD34+_Human0.98295471
141SMAD_19615063_ChIP-ChIP_OVARY_Human0.97970197
142* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97712036
143FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96668800
144SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95864550
145AR_21909140_ChIP-Seq_LNCAP_Human0.95078632
146TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93843172
147SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.93384404
148* VDR_23849224_ChIP-Seq_CD4+_Human0.93132134
149GATA1_26923725_Chip-Seq_HPCs_Mouse0.92842738
150FLI1_27457419_Chip-Seq_LIVER_Mouse0.92128109
151ELF1_17652178_ChIP-ChIP_JURKAT_Human0.91815339
152SUZ12_18555785_Chip-Seq_ESCs_Mouse0.90966898
153NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.89978732
154SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.89474194
155* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.88115551
156SOX9_26525672_Chip-Seq_HEART_Mouse0.87301874
157SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87059158
158* PRDM14_20953172_ChIP-Seq_ESCs_Human0.85935121
159* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.85812539
160NANOG_18555785_Chip-Seq_ESCs_Mouse0.85687743
161THAP11_20581084_ChIP-Seq_MESCs_Mouse0.85434197
162GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84618003
163CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.84323041
164CMYC_18555785_Chip-Seq_ESCs_Mouse0.83039746

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation8.14792994
2MP0003787_abnormal_imprinting5.07467265
3MP0004147_increased_porphyrin_level5.03848135
4MP0000920_abnormal_myelination4.65545916
5MP0003950_abnormal_plasma_membrane4.21657711
6MP0003880_abnormal_central_pattern3.54495013
7* MP0003656_abnormal_erythrocyte_physiolo2.93600458
8MP0001529_abnormal_vocalization2.84358669
9MP0003122_maternal_imprinting2.82842703
10MP0004883_abnormal_blood_vessel2.71133889
11MP0001905_abnormal_dopamine_level2.66573396
12MP0005171_absent_coat_pigmentation2.60596435
13MP0003136_yellow_coat_color2.58755253
14MP0001346_abnormal_lacrimal_gland2.54480267
15MP0005174_abnormal_tail_pigmentation2.45160928
16MP0000015_abnormal_ear_pigmentation2.36263494
17MP0003690_abnormal_glial_cell2.28133848
18MP0003172_abnormal_lysosome_physiology2.26736579
19MP0010678_abnormal_skin_adnexa2.19452719
20MP0000383_abnormal_hair_follicle2.17046510
21MP0002009_preneoplasia2.16694123
22MP0005187_abnormal_penis_morphology2.12881901
23MP0004742_abnormal_vestibular_system2.12277227
24MP0004885_abnormal_endolymph2.10855211
25* MP0008260_abnormal_autophagy1.98671728
26MP0005075_abnormal_melanosome_morpholog1.90006528
27MP0001485_abnormal_pinna_reflex1.89373545
28MP0002332_abnormal_exercise_endurance1.86324932
29MP0003303_peritoneal_inflammation1.77333215
30MP0004270_analgesia1.77227828
31MP0002272_abnormal_nervous_system1.73161110
32* MP0003221_abnormal_cardiomyocyte_apopto1.72798220
33MP0003634_abnormal_glial_cell1.66847595
34MP0001835_abnormal_antigen_presentation1.66672411
35MP0000647_abnormal_sebaceous_gland1.63908575
36MP0004381_abnormal_hair_follicle1.63153926
37MP0008995_early_reproductive_senescence1.60036692
38MP0005164_abnormal_response_to1.58481061
39MP0005451_abnormal_body_composition1.53601340
40MP0005464_abnormal_platelet_physiology1.53277536
41MP0001958_emphysema1.52616791
42MP0000778_abnormal_nervous_system1.52297996
43MP0003329_amyloid_beta_deposits1.50747066
44MP0001851_eye_inflammation1.50074494
45MP0001661_extended_life_span1.49443262
46MP0008057_abnormal_DNA_replication1.48974067
47MP0002938_white_spotting1.44261233
48MP0002166_altered_tumor_susceptibility1.37048690
49MP0008877_abnormal_DNA_methylation1.36348537
50MP0002909_abnormal_adrenal_gland1.35911174
51MP0005408_hypopigmentation1.35826375
52MP0006082_CNS_inflammation1.33050117
53MP0002734_abnormal_mechanical_nocicepti1.30571501
54MP0001486_abnormal_startle_reflex1.30193476
55MP0003828_pulmonary_edema1.29751036
56MP0003938_abnormal_ear_development1.27719525
57MP0000465_gastrointestinal_hemorrhage1.27132132
58MP0001800_abnormal_humoral_immune1.25483255
59MP0003632_abnormal_nervous_system1.25204603
60MP0005409_darkened_coat_color1.24804387
61MP0000372_irregular_coat_pigmentation1.23978537
62MP0002064_seizures1.23031351
63MP0000566_synostosis1.21092587
64MP0005551_abnormal_eye_electrophysiolog1.19977677
65MP0002229_neurodegeneration1.19899051
66MP0003763_abnormal_thymus_physiology1.19280389
67MP0003300_gastrointestinal_ulcer1.18938090
68MP0001963_abnormal_hearing_physiology1.17991865
69MP0002928_abnormal_bile_duct1.17506904
70MP0003123_paternal_imprinting1.15436259
71MP0003091_abnormal_cell_migration1.11814953
72MP0003186_abnormal_redox_activity1.08195238
73MP0003718_maternal_effect1.06691232
74MP0002419_abnormal_innate_immunity1.06098213
75MP0005671_abnormal_response_to1.05606594
76MP0000579_abnormal_nail_morphology1.05206095
77MP0004130_abnormal_muscle_cell1.04017989
78MP0003937_abnormal_limbs/digits/tail_de1.03542924
79* MP0004484_altered_response_of1.01400546
80MP0005195_abnormal_posterior_eye1.00415951
81MP0004808_abnormal_hematopoietic_stem0.99912709
82MP0003315_abnormal_perineum_morphology0.98736357
83MP0000371_diluted_coat_color0.96716582
84* MP0000689_abnormal_spleen_morphology0.96155585
85MP0000762_abnormal_tongue_morphology0.95464976
86MP0003195_calcinosis0.95017286
87MP0002405_respiratory_system_inflammati0.94919542
88MP0004811_abnormal_neuron_physiology0.92748633
89MP0004134_abnormal_chest_morphology0.92222844
90MP0004142_abnormal_muscle_tone0.92155090
91MP0001545_abnormal_hematopoietic_system0.91336458
92MP0005397_hematopoietic_system_phenotyp0.91336458
93MP0000685_abnormal_immune_system0.91333554
94MP0003121_genomic_imprinting0.90972382
95MP0004782_abnormal_surfactant_physiolog0.89446337
96MP0002876_abnormal_thyroid_physiology0.89430117
97MP0005253_abnormal_eye_physiology0.88907497
98MP0005248_abnormal_Harderian_gland0.88735829
99MP0003631_nervous_system_phenotype0.88695584
100MP0002752_abnormal_somatic_nervous0.88430204
101MP0001984_abnormal_olfaction0.87632974
102MP0002420_abnormal_adaptive_immunity0.86848129
103* MP0002398_abnormal_bone_marrow0.86240214
104MP0002723_abnormal_immune_serum0.85935632
105MP0001542_abnormal_bone_strength0.85714794
106MP0002133_abnormal_respiratory_system0.85529478
107MP0005388_respiratory_system_phenotype0.85529478
108MP0005623_abnormal_meninges_morphology0.84763858
109MP0005376_homeostasis/metabolism_phenot0.84221324
110MP0001819_abnormal_immune_cell0.83891652
111MP0006054_spinal_hemorrhage0.83109810
112MP0002095_abnormal_skin_pigmentation0.82842037
113* MP0002722_abnormal_immune_system0.82751218
114MP0000026_abnormal_inner_ear0.82205825
115MP0002736_abnormal_nociception_after0.82130524
116MP0001188_hyperpigmentation0.81579923
117MP0002452_abnormal_antigen_presenting0.81530949
118MP0005367_renal/urinary_system_phenotyp0.80136193
119MP0000516_abnormal_urinary_system0.80136193
120MP0006276_abnormal_autonomic_nervous0.80131557
121MP0002067_abnormal_sensory_capabilities0.78604353
122MP0000716_abnormal_immune_system0.78567876
123MP0001177_atelectasis0.78231667
124MP0002882_abnormal_neuron_morphology0.77407252
125MP0003183_abnormal_peptide_metabolism0.77124523
126MP0001502_abnormal_circadian_rhythm0.76652339
127MP0001970_abnormal_pain_threshold0.76005486
128MP0009765_abnormal_xenobiotic_induced0.75799716
129MP0006292_abnormal_olfactory_placode0.75469351
130MP0005025_abnormal_response_to0.73627669
131MP0009333_abnormal_splenocyte_physiolog0.73626419
132MP0000427_abnormal_hair_cycle0.73481827
133MP0005310_abnormal_salivary_gland0.72987854
134MP0000703_abnormal_thymus_morphology0.72619339
135MP0003724_increased_susceptibility_to0.71101655
136MP0009785_altered_susceptibility_to0.71003954
137MP0002090_abnormal_vision0.70256919
138MP0001915_intracranial_hemorrhage0.70004983
139MP0008874_decreased_physiological_sensi0.69990114
140MP0002102_abnormal_ear_morphology0.69667531
141MP0005058_abnormal_lysosome_morphology0.69637912
142MP0008569_lethality_at_weaning0.69413268
143MP0003633_abnormal_nervous_system0.69331260
144MP0002971_abnormal_brown_adipose0.69303685
145MP0002653_abnormal_ependyma_morphology0.69061226
146MP0003879_abnormal_hair_cell0.68830167
147MP0001879_abnormal_lymphatic_vessel0.68437844
148MP0009046_muscle_twitch0.67089622
149MP0002066_abnormal_motor_capabilities/c0.66635729
150MP0003567_abnormal_fetal_cardiomyocyte0.66545471
151MP0008789_abnormal_olfactory_epithelium0.65855536
152MP0000537_abnormal_urethra_morphology0.64365770
153MP0005266_abnormal_metabolism0.63574186
154MP0008775_abnormal_heart_ventricle0.62980800
155MP0009764_decreased_sensitivity_to0.62748692
156MP0001299_abnormal_eye_distance/0.62226475
157MP0001440_abnormal_grooming_behavior0.62093634
158MP0002638_abnormal_pupillary_reflex0.61900931
159MP0002006_tumorigenesis0.61499049
160MP0004272_abnormal_basement_membrane0.61333320
161MP0000604_amyloidosis0.60923906
162MP0001968_abnormal_touch/_nociception0.60807804
163MP0004036_abnormal_muscle_relaxation0.60737584
164MP0005391_vision/eye_phenotype0.59904849
165MP0003635_abnormal_synaptic_transmissio0.59848619
166MP0003453_abnormal_keratinocyte_physiol0.59637987
167MP0000249_abnormal_blood_vessel0.59435362
168MP0002063_abnormal_learning/memory/cond0.57798505

Predicted human phenotypes

RankGene SetZ-score
1Parkinsonism with favorable response to dopaminergic medication (HP:0002548)7.27204363
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.02404980
3Degeneration of the lateral corticospinal tracts (HP:0002314)5.02404980
4Cerebral hypomyelination (HP:0006808)4.99206439
5T lymphocytopenia (HP:0005403)4.85782224
6Neurofibrillary tangles (HP:0002185)4.55099522
7Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.46663567
8Increased serum pyruvate (HP:0003542)4.43876251
9Abnormality of glycolysis (HP:0004366)4.43876251
10Recurrent bacterial skin infections (HP:0005406)4.37205670
11Abnormality of T cell number (HP:0011839)4.35267739
12Papillary thyroid carcinoma (HP:0002895)4.35171714
13Abnormality of the heme biosynthetic pathway (HP:0010472)4.21041440
14Postural instability (HP:0002172)4.04914611
15Visual hallucinations (HP:0002367)3.99665207
16Parakeratosis (HP:0001036)3.89915059
17Peritonitis (HP:0002586)3.58975879
18Abnormal auditory evoked potentials (HP:0006958)3.56840639
19Sensory axonal neuropathy (HP:0003390)3.55371385
20Hypochromic microcytic anemia (HP:0004840)3.52703434
21Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.49832349
22Gingival bleeding (HP:0000225)3.49407073
23Peripheral hypomyelination (HP:0007182)3.47259691
24Recurrent abscess formation (HP:0002722)3.36664149
25Segmental peripheral demyelination/remyelination (HP:0003481)3.36624807
26Abnormality of the corticospinal tract (HP:0002492)3.29637920
27CNS hypomyelination (HP:0003429)3.25348704
28Cerebral inclusion bodies (HP:0100314)3.18104579
29Paralysis (HP:0003470)3.16324172
30Gastrointestinal infarctions (HP:0005244)3.16053945
31Stenosis of the external auditory canal (HP:0000402)3.08449575
32Congenital ichthyosiform erythroderma (HP:0007431)3.07284796
33Prolonged neonatal jaundice (HP:0006579)3.04421610
34Subacute progressive viral hepatitis (HP:0006572)2.99761342
35Optic neuritis (HP:0100653)2.99309174
36Retrobulbar optic neuritis (HP:0100654)2.99309174
37Conjunctival telangiectasia (HP:0000524)2.98849483
38Thickened helices (HP:0000391)2.93922874
39Orthostatic hypotension (HP:0001278)2.88379560
40Thyroid carcinoma (HP:0002890)2.84792545
41Autoamputation (HP:0001218)2.84185215
42Abnormality of the hip-girdle musculature (HP:0001445)2.82747481
43Abnormality of the musculature of the pelvis (HP:0001469)2.82747481
44Abnormality of the vasculature of the conjunctiva (HP:0008054)2.80776385
45Spontaneous hematomas (HP:0007420)2.79139188
46Onion bulb formation (HP:0003383)2.78988061
47Spastic paraparesis (HP:0002313)2.75914214
48Microcytic anemia (HP:0001935)2.68521231
49Eczematoid dermatitis (HP:0000976)2.67968350
50Hepatosplenomegaly (HP:0001433)2.66441131
51Pelvic girdle muscle weakness (HP:0003749)2.65088093
52Resting tremor (HP:0002322)2.63354164
53Leukodystrophy (HP:0002415)2.61071596
54Amyotrophic lateral sclerosis (HP:0007354)2.60874571
55Leukocytosis (HP:0001974)2.60441851
56Febrile seizures (HP:0002373)2.60111836
57Abnormal hair whorl (HP:0010721)2.59917892
58Orchitis (HP:0100796)2.58351980
593-Methylglutaconic aciduria (HP:0003535)2.57720352
60Recurrent fungal infections (HP:0002841)2.57195426
61Split foot (HP:0001839)2.56988513
62Morphological abnormality of the inner ear (HP:0011390)2.51042887
63Absent septum pellucidum (HP:0001331)2.48318638
64Recurrent skin infections (HP:0001581)2.47784350
65Clumsiness (HP:0002312)2.47145457
66Hip dysplasia (HP:0001385)2.46991870
67Thyroiditis (HP:0100646)2.46952081
68Patchy hypopigmentation of hair (HP:0011365)2.44651229
69Postnatal microcephaly (HP:0005484)2.41442181
70White forelock (HP:0002211)2.40649256
71Hypoplasia of the thymus (HP:0000778)2.39916402
72Absent frontal sinuses (HP:0002688)2.39408041
73Myositis (HP:0100614)2.38926047
74Abnormality of the septum pellucidum (HP:0007375)2.38740271
75Recurrent gram-negative bacterial infections (HP:0005420)2.38311535
76Diaphragmatic weakness (HP:0009113)2.38063172
77Hemiplegia (HP:0002301)2.37724191
78Genetic anticipation (HP:0003743)2.36904128
79Gingivitis (HP:0000230)2.34122443
80Poor speech (HP:0002465)2.33685800
81Delusions (HP:0000746)2.33596934
82Adrenal hypoplasia (HP:0000835)2.30967342
83Abnormality of the fetal cardiovascular system (HP:0010948)2.29196841
84Abnormal umbilical cord blood vessels (HP:0011403)2.29196841
85Single umbilical artery (HP:0001195)2.29196841
86Supranuclear gaze palsy (HP:0000605)2.28015942
87Periodontitis (HP:0000704)2.27825445
88Abnormality of the phalanges of the 2nd finger (HP:0009541)2.25303412
89Hyperventilation (HP:0002883)2.24098109
90Large earlobe (HP:0009748)2.22102772
91Cerebral hemorrhage (HP:0001342)2.21653222
92Keratoconjunctivitis sicca (HP:0001097)2.21517957
93Ankle clonus (HP:0011448)2.20931251
94Termporal pattern (HP:0011008)2.19747018
95Insidious onset (HP:0003587)2.19747018
96Birth length less than 3rd percentile (HP:0003561)2.19563000
97Poikilocytosis (HP:0004447)2.18939576
98Palpebral edema (HP:0100540)2.17814828
99Spastic gait (HP:0002064)2.17255313
100Prolonged bleeding time (HP:0003010)2.15632941
101Keratoconjunctivitis (HP:0001096)2.12983550
102Widely spaced teeth (HP:0000687)2.12581415
103Muscle fiber splitting (HP:0003555)2.11714437
104Cupped ear (HP:0000378)2.10119323
105Arterial thrombosis (HP:0004420)2.08199717
106Absent speech (HP:0001344)2.07130483
107Abnormality of macrophages (HP:0004311)2.06113982
108Stomatitis (HP:0010280)2.05017696
109Acanthocytosis (HP:0001927)2.03084640
110Eosinophilia (HP:0001880)2.02587515
111Spastic tetraparesis (HP:0001285)1.98299108
112Abnormality of the umbilical cord (HP:0010881)1.97978636
113Volvulus (HP:0002580)1.97871105
114Abnormality of eosinophils (HP:0001879)1.97795181
115Septo-optic dysplasia (HP:0100842)1.97283379
116Paraparesis (HP:0002385)1.96458086
117Axonal loss (HP:0003447)1.96112004
118Epistaxis (HP:0000421)1.95517933
119Gaze-evoked nystagmus (HP:0000640)1.94098609
120Conical tooth (HP:0000698)1.93615453
121Recurrent bronchitis (HP:0002837)1.92691833
122Drooling (HP:0002307)1.92519753
123Chest pain (HP:0100749)1.91507942
124Polyphagia (HP:0002591)1.90958125
125Abnormality of T cells (HP:0002843)1.89375749
126Excessive salivation (HP:0003781)1.88526234
127Esophageal atresia (HP:0002032)1.88152843
128Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.87895648
129Humeroradial synostosis (HP:0003041)1.87206271
130Synostosis involving the elbow (HP:0003938)1.87206271
131Vaginal atresia (HP:0000148)1.87043748
132Chronic mucocutaneous candidiasis (HP:0002728)1.85525100
133Recurrent cutaneous fungal infections (HP:0011370)1.85525100
134Neoplasm of the tracheobronchial system (HP:0100552)1.85493550
135Hypoplastic left heart (HP:0004383)1.85366478
136Bladder carcinoma (HP:0002862)1.85133506
137Bladder neoplasm (HP:0009725)1.85133506
138Increased mean platelet volume (HP:0011877)1.84243997
139Abnormal gallbladder morphology (HP:0012437)1.82922189
140Acute hepatic failure (HP:0006554)1.82760310
141Medial flaring of the eyebrow (HP:0010747)1.82554119
142Pheochromocytoma (HP:0002666)1.82393608
143Ileus (HP:0002595)1.81709214
144Corneal dystrophy (HP:0001131)1.81458656
145Cholelithiasis (HP:0001081)1.81452994
146Intention tremor (HP:0002080)1.81440007
147Truncal obesity (HP:0001956)1.81372848
148Hematochezia (HP:0002573)1.80990956
149Neuroendocrine neoplasm (HP:0100634)1.80567682
150Premature skin wrinkling (HP:0100678)1.80521333
151Glucose intolerance (HP:0000833)1.80191530
152Genital tract atresia (HP:0001827)1.78350105
153Anteriorly placed anus (HP:0001545)1.77273788
154Viral hepatitis (HP:0006562)1.76819329
155Seborrheic dermatitis (HP:0001051)1.76350554
156Slow saccadic eye movements (HP:0000514)1.76107964
157True hermaphroditism (HP:0010459)1.75933035
158Alacrima (HP:0000522)1.75578199
159Erythroderma (HP:0001019)1.75119239
160Limb dystonia (HP:0002451)1.74557509
161Transitional cell carcinoma of the bladder (HP:0006740)1.74455312
162Abnormal platelet volume (HP:0011876)1.74232096
163Difficulty running (HP:0009046)1.73478977
164Progressive cerebellar ataxia (HP:0002073)1.72992125
165Gait imbalance (HP:0002141)1.72916090
166Elevated erythrocyte sedimentation rate (HP:0003565)1.71953719
167Abnormal gallbladder physiology (HP:0012438)1.71873941
168Cholecystitis (HP:0001082)1.71873941
169Hypoplasia of the uterus (HP:0000013)1.71860417
170Stomach cancer (HP:0012126)1.71780207
171Congenital primary aphakia (HP:0007707)1.70817770
172Abolished electroretinogram (ERG) (HP:0000550)1.70005935
173Congenital malformation of the right heart (HP:0011723)1.69752228
174Double outlet right ventricle (HP:0001719)1.69752228
175Increased neuronal autofluorescent lipopigment (HP:0002074)1.69191017
176Myokymia (HP:0002411)1.68503669
177Renal Fanconi syndrome (HP:0001994)1.68370350
178Long nose (HP:0003189)1.68365489
179Stridor (HP:0010307)1.68135246
180Pancreatic cysts (HP:0001737)1.67438069
181Dysmetria (HP:0001310)1.67162112
182Nasolacrimal duct obstruction (HP:0000579)1.66906485
183Abnormality of the labia minora (HP:0012880)1.66798795
184Scanning speech (HP:0002168)1.66490535
185Cutaneous photosensitivity (HP:0000992)1.66171163
186Hypoplastic pelvis (HP:0008839)1.63379832

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.89128153
2OXSR13.90089072
3PBK3.62005846
4BCR3.17049352
5CASK3.04001321
6GRK62.79792718
7CDK192.63664754
8MAPKAPK52.58372026
9FRK2.56965486
10LIMK12.42423660
11SGK22.42411890
12BUB12.25619564
13RIPK42.20844514
14CSNK1G32.18805101
15PKN11.99327836
16EPHB11.98036154
17FGFR21.95109857
18IKBKE1.94467818
19CSNK1A1L1.90037962
20MST41.86414020
21BLK1.83429822
22EIF2AK11.78851718
23NEK61.76965719
24SGK4941.74994854
25SGK2231.74994854
26DYRK21.71862207
27CAMKK21.71237567
28ARAF1.69158667
29CSNK1G11.67355397
30EPHA31.67112911
31TAOK31.61181231
32KSR11.60782790
33ERBB21.60427082
34SGK31.60224468
35MET1.59750252
36MAP3K41.59332744
37STK161.52933621
38CSNK1G21.51154908
39MKNK11.47024568
40CSK1.44812112
41FGFR31.40998645
42PAK31.40363068
43WNK41.37831586
44MAP4K21.33244850
45TSSK61.32166508
46PLK21.31688034
47NLK1.31168774
48SYK1.30297650
49CAMK2B1.30065432
50MAP3K21.29491321
51DYRK31.25999969
52PIK3CG1.25428631
53TRIM281.23810255
54AKT31.14431594
55BMPR1B1.14309446
56JAK31.13936681
57FES1.13440792
58CLK11.13225480
59MAP2K31.12689789
60ROCK21.10471669
61IRAK11.07730829
62PNCK1.05677360
63TRPM71.05605161
64MAP3K121.04918215
65TXK1.04075261
66MAP3K61.01926893
67JAK11.00538858
68FGR1.00503886
69PIM10.98765610
70MAP2K40.94322239
71ERBB30.93378609
72PLK30.92214001
73RPS6KA50.91487370
74MAP3K50.90906667
75PRPF4B0.87842817
76JAK20.86446226
77CDK140.85031624
78DYRK1B0.84242779
79STK40.83860201
80TYK20.82795789
81HCK0.82547738
82MARK20.82527467
83PLK40.82028329
84ZAK0.78082288
85PDK20.77916388
86CAMK2D0.77763023
87MARK10.76239813
88TEC0.75801528
89SGK10.75622307
90LYN0.75431853
91STK380.74017427
92WNK10.73663914
93ADRBK10.73209787
94TAOK10.73129146
95WNK30.72881645
96NUAK10.72024999
97MELK0.71853397
98DYRK1A0.71301403
99CAMK2G0.70298360
100UHMK10.70261929
101EGFR0.70189737
102STK110.69982040
103VRK10.69974775
104MARK30.69550407
105CAMK40.68883368
106BRAF0.68325234
107BTK0.68168852
108NTRK30.68080583
109RAF10.67716121
110MKNK20.67653142
111TIE10.65922612
112EPHA40.65193963
113OBSCN0.64829990
114PRKCE0.64709426
115ACVR1B0.64618761
116CDK30.63287948
117TGFBR20.63160715
118MAP2K70.61259600
119SRPK10.60441505
120BRD40.59291419
121MATK0.58866568
122BRSK20.56875097
123PKN20.54480600
124CDK180.54347547
125MAP3K140.54284806
126MAP3K10.54226316
127GRK50.54029726
128CDK150.52529522
129NTRK20.50258910
130PRKCQ0.50049795
131NTRK10.49739294
132STK30.49650797
133RET0.48572604
134CDK11A0.48335484
135TESK20.47823502
136DAPK30.47572616
137CAMK2A0.46998563
138CHUK0.46423759
139MAPK130.46093366
140NEK90.45685975
141TLK10.44114550
142MAP2K20.43738604
143RPS6KA40.43254445
144LCK0.43253209
145MUSK0.42252658
146CSNK1A10.42164369
147YES10.42067986
148KSR20.41757808
149GRK70.40455684
150PIK3CA0.37463754
151BMPR20.36537142
152CDK50.35920430
153IRAK20.35317660
154NME10.34803481
155MYLK0.34509583
156PAK10.32505403
157GRK10.31850447
158PRKACB0.30996658
159IRAK40.30009377
160WEE10.28945650
161PTK2B0.27799272
162ILK0.27594198
163TNIK0.27573907
164FGFR10.27438860
165ADRBK20.26768599
166PRKG10.26313814
167PINK10.25577420
168CSNK1D0.24219619
169ABL20.22941403

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.90167578
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.40260001
3Fatty acid elongation_Homo sapiens_hsa000623.17157149
4Steroid biosynthesis_Homo sapiens_hsa001003.09276864
5Ether lipid metabolism_Homo sapiens_hsa005652.97877178
6Proteasome_Homo sapiens_hsa030502.82387999
7Collecting duct acid secretion_Homo sapiens_hsa049662.70493648
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.55280500
9SNARE interactions in vesicular transport_Homo sapiens_hsa041302.32875619
10RNA polymerase_Homo sapiens_hsa030202.28953689
11Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.23010846
12Protein export_Homo sapiens_hsa030602.21288228
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.14946993
14Oxidative phosphorylation_Homo sapiens_hsa001902.06975768
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05372798
16Rheumatoid arthritis_Homo sapiens_hsa053231.98011838
17Non-small cell lung cancer_Homo sapiens_hsa052231.88160078
18Regulation of autophagy_Homo sapiens_hsa041401.85107344
19Sphingolipid metabolism_Homo sapiens_hsa006001.79325432
20Osteoclast differentiation_Homo sapiens_hsa043801.75883705
21FoxO signaling pathway_Homo sapiens_hsa040681.72602453
22Leishmaniasis_Homo sapiens_hsa051401.64676981
23B cell receptor signaling pathway_Homo sapiens_hsa046621.62083019
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.59968979
25Parkinsons disease_Homo sapiens_hsa050121.59160708
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.57974330
27Basal transcription factors_Homo sapiens_hsa030221.56830847
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.51999500
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.48677058
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.47318325
31Endometrial cancer_Homo sapiens_hsa052131.46146525
32Prolactin signaling pathway_Homo sapiens_hsa049171.45481125
33Legionellosis_Homo sapiens_hsa051341.44993263
34Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.40112301
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.38568660
36Platelet activation_Homo sapiens_hsa046111.37604486
37T cell receptor signaling pathway_Homo sapiens_hsa046601.36688002
38Linoleic acid metabolism_Homo sapiens_hsa005911.36632614
39Vibrio cholerae infection_Homo sapiens_hsa051101.36211616
40Inositol phosphate metabolism_Homo sapiens_hsa005621.35972664
41Tuberculosis_Homo sapiens_hsa051521.34714852
42Renal cell carcinoma_Homo sapiens_hsa052111.32559250
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.31987044
44Phagosome_Homo sapiens_hsa041451.27131522
45Measles_Homo sapiens_hsa051621.22464073
46Pancreatic cancer_Homo sapiens_hsa052121.20439374
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.20276489
48mTOR signaling pathway_Homo sapiens_hsa041501.17312760
49Neurotrophin signaling pathway_Homo sapiens_hsa047221.15943784
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14280357
51Toll-like receptor signaling pathway_Homo sapiens_hsa046201.14033961
52Axon guidance_Homo sapiens_hsa043601.13054264
53HIF-1 signaling pathway_Homo sapiens_hsa040661.11720905
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.11185736
55NF-kappa B signaling pathway_Homo sapiens_hsa040641.10932367
56Longevity regulating pathway - mammal_Homo sapiens_hsa042111.10258584
57Arachidonic acid metabolism_Homo sapiens_hsa005901.09410506
58Autoimmune thyroid disease_Homo sapiens_hsa053201.09189905
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08809880
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08394980
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07908704
62Alzheimers disease_Homo sapiens_hsa050101.05899751
63Lysosome_Homo sapiens_hsa041421.03212223
64Hepatitis B_Homo sapiens_hsa051611.03086852
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02185793
66Synaptic vesicle cycle_Homo sapiens_hsa047211.00967558
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.99365394
68Long-term potentiation_Homo sapiens_hsa047200.97059679
69Cholinergic synapse_Homo sapiens_hsa047250.96805416
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95347724
71Type II diabetes mellitus_Homo sapiens_hsa049300.94950084
72Tight junction_Homo sapiens_hsa045300.94339103
73Endocytosis_Homo sapiens_hsa041440.91761605
74Glutathione metabolism_Homo sapiens_hsa004800.91620963
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.91026672
76AMPK signaling pathway_Homo sapiens_hsa041520.90915543
77Circadian rhythm_Homo sapiens_hsa047100.85585974
78Histidine metabolism_Homo sapiens_hsa003400.84971236
79Chronic myeloid leukemia_Homo sapiens_hsa052200.82866884
80Glioma_Homo sapiens_hsa052140.82453100
81ErbB signaling pathway_Homo sapiens_hsa040120.82067201
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81765105
83Cell cycle_Homo sapiens_hsa041100.81427859
84Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80362837
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.78704153
86Serotonergic synapse_Homo sapiens_hsa047260.78228947
87Choline metabolism in cancer_Homo sapiens_hsa052310.77681701
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76411110
89Colorectal cancer_Homo sapiens_hsa052100.76349298
90Hepatitis C_Homo sapiens_hsa051600.76027434
91Huntingtons disease_Homo sapiens_hsa050160.75558713
92Nicotine addiction_Homo sapiens_hsa050330.75132918
93TNF signaling pathway_Homo sapiens_hsa046680.74787349
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73160419
95Toxoplasmosis_Homo sapiens_hsa051450.72047459
96GABAergic synapse_Homo sapiens_hsa047270.71174973
97Apoptosis_Homo sapiens_hsa042100.71019493
98Influenza A_Homo sapiens_hsa051640.70830987
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69887162
100Folate biosynthesis_Homo sapiens_hsa007900.69744761
101Staphylococcus aureus infection_Homo sapiens_hsa051500.69265232
102Malaria_Homo sapiens_hsa051440.69112648
103Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68832004
104Phototransduction_Homo sapiens_hsa047440.68618547
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.68389815
106Dopaminergic synapse_Homo sapiens_hsa047280.67439587
107Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67378033
108Taste transduction_Homo sapiens_hsa047420.66821295
109Acute myeloid leukemia_Homo sapiens_hsa052210.66321412
110MicroRNAs in cancer_Homo sapiens_hsa052060.65140641
111Graft-versus-host disease_Homo sapiens_hsa053320.64706159
112Notch signaling pathway_Homo sapiens_hsa043300.64162714
113Morphine addiction_Homo sapiens_hsa050320.63014604
114Gap junction_Homo sapiens_hsa045400.63014310
115Rap1 signaling pathway_Homo sapiens_hsa040150.62250188
116Systemic lupus erythematosus_Homo sapiens_hsa053220.61092970
117GnRH signaling pathway_Homo sapiens_hsa049120.60614734
118Ras signaling pathway_Homo sapiens_hsa040140.60438349
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60193229
120Alcoholism_Homo sapiens_hsa050340.60104198
121Circadian entrainment_Homo sapiens_hsa047130.58558139
122Oocyte meiosis_Homo sapiens_hsa041140.58539830
123Fatty acid biosynthesis_Homo sapiens_hsa000610.58360535
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58242646
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58161512
126Amphetamine addiction_Homo sapiens_hsa050310.57476261
127Asthma_Homo sapiens_hsa053100.57103697
128VEGF signaling pathway_Homo sapiens_hsa043700.56349459
129Renin secretion_Homo sapiens_hsa049240.55542175
130Vitamin digestion and absorption_Homo sapiens_hsa049770.55389567
131MAPK signaling pathway_Homo sapiens_hsa040100.54728040
132Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54164904
133Purine metabolism_Homo sapiens_hsa002300.54103929
134Long-term depression_Homo sapiens_hsa047300.53818458
135Oxytocin signaling pathway_Homo sapiens_hsa049210.52564675
136Ribosome_Homo sapiens_hsa030100.52511770
137Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52380846
138Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.51826754
139Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.51756135
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.49541248
141cAMP signaling pathway_Homo sapiens_hsa040240.46941997
142Hippo signaling pathway_Homo sapiens_hsa043900.44849678
143Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44313995
144Spliceosome_Homo sapiens_hsa030400.42399576
145Nucleotide excision repair_Homo sapiens_hsa034200.42324588
146Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41947434
147Mineral absorption_Homo sapiens_hsa049780.40305372
148Leukocyte transendothelial migration_Homo sapiens_hsa046700.40173049
149NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38888269
150Epstein-Barr virus infection_Homo sapiens_hsa051690.38348164
151Prostate cancer_Homo sapiens_hsa052150.37889436
152Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37866827
153Hematopoietic cell lineage_Homo sapiens_hsa046400.37798002
154TGF-beta signaling pathway_Homo sapiens_hsa043500.37228376
155PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35887145
156Metabolic pathways_Homo sapiens_hsa011000.35638025
157Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35203430
158Sulfur metabolism_Homo sapiens_hsa009200.33045177
159Arginine and proline metabolism_Homo sapiens_hsa003300.32865144
160Glutamatergic synapse_Homo sapiens_hsa047240.32834453
161RNA degradation_Homo sapiens_hsa030180.32008719
162RNA transport_Homo sapiens_hsa030130.31651558
163Chemokine signaling pathway_Homo sapiens_hsa040620.29906656
164Vascular smooth muscle contraction_Homo sapiens_hsa042700.29493246
165Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28754341
166Hedgehog signaling pathway_Homo sapiens_hsa043400.28656937
167Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28656561
168Shigellosis_Homo sapiens_hsa051310.27749457
169Melanoma_Homo sapiens_hsa052180.26874456
170Allograft rejection_Homo sapiens_hsa053300.25887301
171Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24487430
172Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24244053
173Tyrosine metabolism_Homo sapiens_hsa003500.23762939
174Ovarian steroidogenesis_Homo sapiens_hsa049130.23610018
175Dorso-ventral axis formation_Homo sapiens_hsa043200.22869901

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