ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of mitochondrial fission (GO:0090141)	4.94442304
2	pyrimidine nucleobase catabolic process (GO:0006208)	4.80023206
3	behavioral response to nicotine (GO:0035095)	4.42662787
4	protein neddylation (GO:0045116)	4.20015681
5	chaperone-mediated protein transport (GO:0072321)	4.15974765
6	gamma-aminobutyric acid transport (GO:0015812)	4.06806277
7	protein-cofactor linkage (GO:0018065)	4.03519417
8	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.86977676
9	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.81741213
10	nucleobase catabolic process (GO:0046113)	3.80698983
11	substrate-independent telencephalic tangential migration (GO:0021826)	3.75458081
12	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.75458081
13	nonmotile primary cilium assembly (GO:0035058)	3.70199552
14	epithelial cilium movement (GO:0003351)	3.66320655
15	ATP synthesis coupled proton transport (GO:0015986)	3.65353430
16	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.65353430
17	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.60830831
18	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	3.58345461
19	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	3.58345461
20	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.57171106
21	protein complex biogenesis (GO:0070271)	3.47597272
22	transmission of nerve impulse (GO:0019226)	3.45911275
23	retinal ganglion cell axon guidance (GO:0031290)	3.36285180
24	postsynaptic membrane organization (GO:0001941)	3.35886163
25	somite development (GO:0061053)	3.33964326
26	regulation of mitochondrial fission (GO:0090140)	3.30102459
27	intraciliary transport (GO:0042073)	3.29530955
28	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.25147555
29	NADH dehydrogenase complex assembly (GO:0010257)	3.25147555
30	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.25147555
31	neuron fate determination (GO:0048664)	3.23062453
32	proline transport (GO:0015824)	3.21438978
33	mitochondrial respiratory chain complex assembly (GO:0033108)	3.16854228
34	cell proliferation in forebrain (GO:0021846)	3.12410807
35	protein localization to cilium (GO:0061512)	3.12345459
36	respiratory electron transport chain (GO:0022904)	3.10874966
37	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.10546501
38	electron transport chain (GO:0022900)	3.06034709
39	axoneme assembly (GO:0035082)	3.05697261
40	regulation of cilium movement (GO:0003352)	3.04207218
41	axonal fasciculation (GO:0007413)	2.96142035
42	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.95929992
43	presynaptic membrane assembly (GO:0097105)	2.93619420
44	establishment of mitochondrion localization (GO:0051654)	2.93204048
45	cilium morphogenesis (GO:0060271)	2.88053710
46	spinal cord association neuron differentiation (GO:0021527)	2.82413068
47	ribonucleoprotein complex disassembly (GO:0032988)	2.80605715
48	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.78981633
49	viral transcription (GO:0019083)	2.77632244
50	cilium movement (GO:0003341)	2.76214952
51	sequestering of actin monomers (GO:0042989)	2.76128646
52	protein localization to synapse (GO:0035418)	2.75457575
53	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.75053478
54	negative regulation of response to food (GO:0032096)	2.74656143
55	negative regulation of appetite (GO:0032099)	2.74656143
56	ubiquinone metabolic process (GO:0006743)	2.73097999
57	presynaptic membrane organization (GO:0097090)	2.72552208
58	translational termination (GO:0006415)	2.72318569
59	organelle disassembly (GO:1903008)	2.71701829
60	protein polyglutamylation (GO:0018095)	2.68413226
61	negative regulation of membrane potential (GO:0045837)	2.67324270
62	cerebral cortex radially oriented cell migration (GO:0021799)	2.65466257
63	olfactory bulb development (GO:0021772)	2.64348797
64	ubiquinone biosynthetic process (GO:0006744)	2.64184687
65	cellular response to leptin stimulus (GO:0044320)	2.63077587
66	cotranslational protein targeting to membrane (GO:0006613)	2.61150403
67	short-term memory (GO:0007614)	2.54691487
68	water-soluble vitamin biosynthetic process (GO:0042364)	2.54570274
69	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.54491442
70	synapse assembly (GO:0007416)	2.54398066
71	telencephalon development (GO:0021537)	2.53584396
72	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.53506705
73	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.53506705
74	synaptic vesicle maturation (GO:0016188)	2.53232412
75	neurofilament cytoskeleton organization (GO:0060052)	2.52285096
76	neuron cell-cell adhesion (GO:0007158)	2.50839071
77	cholesterol biosynthetic process (GO:0006695)	2.50783216
78	cilium organization (GO:0044782)	2.49867489
79	cilium assembly (GO:0042384)	2.49398918
80	intracellular protein transmembrane import (GO:0044743)	2.48947671
81	protein targeting to ER (GO:0045047)	2.47294155
82	regulation of microtubule-based movement (GO:0060632)	2.44914561
83	neuron recognition (GO:0008038)	2.44605628
84	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.43939101
85	anterograde axon cargo transport (GO:0008089)	2.43543223
86	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.42505820
87	adult walking behavior (GO:0007628)	2.42444166
88	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.40640570
89	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.40492817
90	regulation of development, heterochronic (GO:0040034)	2.40051697
91	regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)	2.39662580
92	dendritic spine morphogenesis (GO:0060997)	2.38466138
93	protein localization to endoplasmic reticulum (GO:0070972)	2.36443461
94	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.34405571
95	establishment of melanosome localization (GO:0032401)	2.33374732
96	platelet dense granule organization (GO:0060155)	2.32420868
97	behavioral fear response (GO:0001662)	2.32121857
98	behavioral defense response (GO:0002209)	2.32121857
99	translational elongation (GO:0006414)	2.31641117
100	synaptic transmission, cholinergic (GO:0007271)	2.30631425

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.98992216
2	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.62642925
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.26481949
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.56386422
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.50497184
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.49023738
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.44903411
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.27013051
9	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.22273001
10	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.13329302
11	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.12976480
12	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.05878780
13	VDR_22108803_ChIP-Seq_LS180_Human	2.05658832
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.99010350
15	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.98603515
16	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.98550832
17	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.87619416
18	GBX2_23144817_ChIP-Seq_PC3_Human	1.87396847
19	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.84768720
20	RNF2_27304074_Chip-Seq_NSC_Mouse	1.84308242
21	FUS_26573619_Chip-Seq_HEK293_Human	1.79829505
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.79703961
23	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.79617110
24	IRF1_19129219_ChIP-ChIP_H3396_Human	1.73416676
25	EWS_26573619_Chip-Seq_HEK293_Human	1.72628724
26	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.70287692
27	TAF15_26573619_Chip-Seq_HEK293_Human	1.68618856
28	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.65443926
29	REST_21632747_ChIP-Seq_MESCs_Mouse	1.63573797
30	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.61725073
31	P300_19829295_ChIP-Seq_ESCs_Human	1.59331901
32	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.58045377
33	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.55725308
34	ELK1_19687146_ChIP-ChIP_HELA_Human	1.50620361
35	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.50127338
36	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.48737796
37	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.48595295
38	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.48217294
39	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.41045093
40	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.39626677
41	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.39616345
42	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.39376017
43	MYC_18940864_ChIP-ChIP_HL60_Human	1.38720907
44	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.36780474
45	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.34664274
46	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.29945893
47	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.28366665
48	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.26962088
49	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.26454685
50	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.25958038
51	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.25460715
52	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.25459181
53	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.24098703
54	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.23219149
55	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.17475535
56	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.17030653
57	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.16865422
58	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.16514258
59	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.15535921
60	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.15271833
61	TP53_22573176_ChIP-Seq_HFKS_Human	1.15187117
62	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.14269582
63	VDR_23849224_ChIP-Seq_CD4+_Human	1.12418036
64	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.12174662
65	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.11278546
66	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.09473528
67	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.09473528
68	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.08853729
69	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.07769798
70	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.06687581
71	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.06244116
72	GABP_19822575_ChIP-Seq_HepG2_Human	1.04296597
73	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.02317338
74	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.01087521
75	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.00697866
76	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.00204023
77	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.99523528
78	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.98875329
79	CBP_20019798_ChIP-Seq_JUKART_Human	0.98135993
80	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.98135993
81	JUN_21703547_ChIP-Seq_K562_Human	0.97351607
82	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.96293315
83	TTF2_22483619_ChIP-Seq_HELA_Human	0.96153010
84	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.96129668
85	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.95951497
86	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.95476849
87	AR_25329375_ChIP-Seq_VCAP_Human	0.94407931
88	HTT_18923047_ChIP-ChIP_STHdh_Human	0.93254201
89	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.92746287
90	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.90792127
91	RUNX2_22187159_ChIP-Seq_PCA_Human	0.90061060
92	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.89282956
93	FOXP3_21729870_ChIP-Seq_TREG_Human	0.89161774
94	NANOG_19829295_ChIP-Seq_ESCs_Human	0.88822190
95	SOX2_19829295_ChIP-Seq_ESCs_Human	0.88822190
96	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.88660431
97	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.87980317
98	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.87815209
99	SMAD4_21799915_ChIP-Seq_A2780_Human	0.86897467
100	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.86266791

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.75826880
2	MP0003880_abnormal_central_pattern	3.14276021
3	MP0003122_maternal_imprinting	2.93822613
4	MP0003787_abnormal_imprinting	2.52968841
5	MP0006276_abnormal_autonomic_nervous	2.47961981
6	MP0001529_abnormal_vocalization	2.47247332
7	MP0003136_yellow_coat_color	2.45409119
8	MP0002653_abnormal_ependyma_morphology	2.37515887
9	MP0004142_abnormal_muscle_tone	2.34995741
10	MP0003121_genomic_imprinting	2.34158180
11	MP0005499_abnormal_olfactory_system	2.26328990
12	MP0005394_taste/olfaction_phenotype	2.26328990
13	MP0000778_abnormal_nervous_system	2.17655486
14	MP0008789_abnormal_olfactory_epithelium	2.16953561
15	MP0001984_abnormal_olfaction	2.09175347
16	MP0004859_abnormal_synaptic_plasticity	1.95519827
17	MP0009046_muscle_twitch	1.91376796
18	MP0006072_abnormal_retinal_apoptosis	1.90782132
19	MP0008877_abnormal_DNA_methylation	1.88524214
20	MP0002102_abnormal_ear_morphology	1.87952491
21	MP0009379_abnormal_foot_pigmentation	1.81796345
22	MP0002272_abnormal_nervous_system	1.75699304
23	MP0004133_heterotaxia	1.70000361
24	MP0000049_abnormal_middle_ear	1.69068724
25	MP0005423_abnormal_somatic_nervous	1.65725305
26	MP0009745_abnormal_behavioral_response	1.65290808
27	MP0003635_abnormal_synaptic_transmissio	1.59729192
28	MP0002837_dystrophic_cardiac_calcinosis	1.58144431
29	MP0001293_anophthalmia	1.55179430
30	MP0001968_abnormal_touch/_nociception	1.53123146
31	MP0000631_abnormal_neuroendocrine_gland	1.51929018
32	MP0002572_abnormal_emotion/affect_behav	1.50100874
33	MP0010030_abnormal_orbit_morphology	1.48471731
34	MP0002938_white_spotting	1.46997217
35	MP0005551_abnormal_eye_electrophysiolog	1.46924005
36	MP0002736_abnormal_nociception_after	1.45858068
37	MP0004885_abnormal_endolymph	1.45590801
38	MP0002163_abnormal_gland_morphology	1.45589609
39	MP0005253_abnormal_eye_physiology	1.42240415
40	MP0003890_abnormal_embryonic-extraembry	1.41412934
41	MP0002184_abnormal_innervation	1.41208816
42	MP0003123_paternal_imprinting	1.40870784
43	MP0001905_abnormal_dopamine_level	1.40121255
44	MP0002638_abnormal_pupillary_reflex	1.40047886
45	MP0002557_abnormal_social/conspecific_i	1.39291417
46	MP0000955_abnormal_spinal_cord	1.38456731
47	MP0001485_abnormal_pinna_reflex	1.37567009
48	MP0002822_catalepsy	1.34005537
49	MP0002063_abnormal_learning/memory/cond	1.32702613
50	MP0005248_abnormal_Harderian_gland	1.32473165
51	MP0002064_seizures	1.31739888
52	MP0005645_abnormal_hypothalamus_physiol	1.30755394
53	MP0003011_delayed_dark_adaptation	1.28502140
54	MP0000026_abnormal_inner_ear	1.27529515
55	MP0002752_abnormal_somatic_nervous	1.25462642
56	MP0002734_abnormal_mechanical_nocicepti	1.25022872
57	MP0002234_abnormal_pharynx_morphology	1.22487097
58	MP0003938_abnormal_ear_development	1.22086857
59	MP0001970_abnormal_pain_threshold	1.21554894
60	MP0002067_abnormal_sensory_capabilities	1.20949269
61	MP0002882_abnormal_neuron_morphology	1.17051269
62	MP0008995_early_reproductive_senescence	1.14101343
63	MP0005195_abnormal_posterior_eye	1.14053223
64	MP0002733_abnormal_thermal_nociception	1.11497852
65	MP0003195_calcinosis	1.09952477
66	MP0002233_abnormal_nose_morphology	1.09717407
67	MP0002909_abnormal_adrenal_gland	1.07592601
68	MP0001963_abnormal_hearing_physiology	1.06561734
69	MP0005646_abnormal_pituitary_gland	1.05947710
70	MP0001486_abnormal_startle_reflex	1.05837795
71	MP0004811_abnormal_neuron_physiology	1.05793335
72	MP0002751_abnormal_autonomic_nervous	1.05178930
73	MP0005379_endocrine/exocrine_gland_phen	1.04574391
74	MP0005377_hearing/vestibular/ear_phenot	1.04118802
75	MP0003878_abnormal_ear_physiology	1.04118802
76	MP0004270_analgesia	1.03981405
77	MP0002152_abnormal_brain_morphology	1.02786022
78	MP0005386_behavior/neurological_phenoty	1.00431999
79	MP0004924_abnormal_behavior	1.00431999
80	MP0001286_abnormal_eye_development	0.99033009
81	MP0005391_vision/eye_phenotype	0.97642665
82	MP0003119_abnormal_digestive_system	0.97210796
83	MP0002735_abnormal_chemical_nociception	0.96958234
84	MP0003937_abnormal_limbs/digits/tail_de	0.96232570
85	MP0000372_irregular_coat_pigmentation	0.95709340
86	MP0001502_abnormal_circadian_rhythm	0.93111641
87	MP0003567_abnormal_fetal_cardiomyocyte	0.92166085
88	MP0003861_abnormal_nervous_system	0.91659044
89	MP0004145_abnormal_muscle_electrophysio	0.86427759
90	MP0005084_abnormal_gallbladder_morpholo	0.85344751
91	MP0004742_abnormal_vestibular_system	0.82644305
92	MP0001440_abnormal_grooming_behavior	0.82635272
93	MP0003755_abnormal_palate_morphology	0.81888035
94	MP0000647_abnormal_sebaceous_gland	0.81644865
95	MP0002066_abnormal_motor_capabilities/c	0.81297202
96	MP0010386_abnormal_urinary_bladder	0.79745547
97	MP0002095_abnormal_skin_pigmentation	0.78180323
98	MP0002229_neurodegeneration	0.77243086
99	MP0003186_abnormal_redox_activity	0.74824705
100	MP0002928_abnormal_bile_duct	0.74235237

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic fibrosis (HP:0100732)	4.28101353
2	Myokymia (HP:0002411)	3.88466457
3	Pancreatic cysts (HP:0001737)	3.84306420
4	Medial flaring of the eyebrow (HP:0010747)	3.80221437
5	Acute necrotizing encephalopathy (HP:0006965)	3.75171988
6	Gait imbalance (HP:0002141)	3.74281082
7	Abnormality of midbrain morphology (HP:0002418)	3.72246850
8	Molar tooth sign on MRI (HP:0002419)	3.72246850
9	True hermaphroditism (HP:0010459)	3.64539924
10	Congenital primary aphakia (HP:0007707)	3.44198584
11	Abnormal mitochondria in muscle tissue (HP:0008316)	3.42632528
12	Nephrogenic diabetes insipidus (HP:0009806)	3.27047231
13	Polyphagia (HP:0002591)	3.26724167
14	Acute encephalopathy (HP:0006846)	3.24326606
15	Mitochondrial inheritance (HP:0001427)	3.07788291
16	Progressive macrocephaly (HP:0004481)	3.02047233
17	Nephronophthisis (HP:0000090)	2.93550272
18	Sclerocornea (HP:0000647)	2.80292361
19	Increased CSF lactate (HP:0002490)	2.75925465
20	Septo-optic dysplasia (HP:0100842)	2.72376695
21	Oligodactyly (hands) (HP:0001180)	2.68054157
22	Hyperglycinemia (HP:0002154)	2.67659769
23	Abnormality of the labia minora (HP:0012880)	2.67535501
24	Retinal dysplasia (HP:0007973)	2.67018235
25	Chronic hepatic failure (HP:0100626)	2.58558646
26	Type II lissencephaly (HP:0007260)	2.53503963
27	Cystic liver disease (HP:0006706)	2.52300767
28	Vaginal atresia (HP:0000148)	2.48975512
29	Stenosis of the external auditory canal (HP:0000402)	2.48237982
30	Adrenal hypoplasia (HP:0000835)	2.46746272
31	Poor suck (HP:0002033)	2.45145780
32	Genital tract atresia (HP:0001827)	2.40536197
33	Specific learning disability (HP:0001328)	2.39158668
34	Median cleft lip (HP:0000161)	2.39154258
35	Hepatocellular necrosis (HP:0001404)	2.38734149
36	Anophthalmia (HP:0000528)	2.36808266
37	Anencephaly (HP:0002323)	2.35454184
38	Lissencephaly (HP:0001339)	2.34651149
39	Poor coordination (HP:0002370)	2.33809478
40	Cerebral edema (HP:0002181)	2.32860852
41	Abnormality of the renal medulla (HP:0100957)	2.30910617
42	Increased hepatocellular lipid droplets (HP:0006565)	2.29884316
43	Failure to thrive in infancy (HP:0001531)	2.27582812
44	Limb dystonia (HP:0002451)	2.27301834
45	Lipid accumulation in hepatocytes (HP:0006561)	2.25637182
46	Hepatic necrosis (HP:0002605)	2.24703823
47	Reticulocytopenia (HP:0001896)	2.24054616
48	Postaxial foot polydactyly (HP:0001830)	2.22754179
49	Optic nerve hypoplasia (HP:0000609)	2.17901517
50	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.17176183
51	Postaxial hand polydactyly (HP:0001162)	2.15697056
52	Abnormality of cells of the erythroid lineage (HP:0012130)	2.13092896
53	Preaxial hand polydactyly (HP:0001177)	2.12771604
54	3-Methylglutaconic aciduria (HP:0003535)	2.09680919
55	Optic disc pallor (HP:0000543)	2.08415156
56	Oligodactyly (HP:0012165)	2.07828327
57	Pendular nystagmus (HP:0012043)	2.07523965
58	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.97740533
59	Congenital hepatic fibrosis (HP:0002612)	1.96518333
60	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.95947479
61	Abnormal eating behavior (HP:0100738)	1.94606643
62	Labial hypoplasia (HP:0000066)	1.93947925
63	Hepatoblastoma (HP:0002884)	1.92175224
64	Agitation (HP:0000713)	1.91901706
65	Rib fusion (HP:0000902)	1.91517428
66	Cortical dysplasia (HP:0002539)	1.91103483
67	Pachygyria (HP:0001302)	1.91029566
68	Colon cancer (HP:0003003)	1.90015048
69	Growth hormone deficiency (HP:0000824)	1.89287124
70	Broad foot (HP:0001769)	1.88088604
71	Male pseudohermaphroditism (HP:0000037)	1.87219570
72	Aplasia/Hypoplasia of the lens (HP:0008063)	1.86350336
73	Spastic tetraplegia (HP:0002510)	1.84421277
74	Abnormal number of erythroid precursors (HP:0012131)	1.83381655
75	Hypoplastic female external genitalia (HP:0012815)	1.82397243
76	Broad alveolar ridges (HP:0000187)	1.82111401
77	X-linked dominant inheritance (HP:0001423)	1.79909226
78	Lactic acidosis (HP:0003128)	1.78433042
79	Drooling (HP:0002307)	1.77999379
80	Asplenia (HP:0001746)	1.77621451
81	Increased serum lactate (HP:0002151)	1.77101590
82	Renal Fanconi syndrome (HP:0001994)	1.75887445
83	Intestinal atresia (HP:0011100)	1.75788348
84	Aganglionic megacolon (HP:0002251)	1.75214082
85	Maternal diabetes (HP:0009800)	1.74434534
86	Decreased testicular size (HP:0008734)	1.73977179
87	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.73931280
88	Abnormal respiratory epithelium morphology (HP:0012253)	1.73242700
89	Abnormal respiratory motile cilium morphology (HP:0005938)	1.73242700
90	Absent septum pellucidum (HP:0001331)	1.71992732
91	Supernumerary spleens (HP:0009799)	1.71324447
92	Narrow forehead (HP:0000341)	1.71298709
93	Hyperglycinuria (HP:0003108)	1.71255491
94	Increased serum pyruvate (HP:0003542)	1.69763130
95	Abnormality of serine family amino acid metabolism (HP:0010894)	1.68949107
96	Abnormality of glycine metabolism (HP:0010895)	1.68949107
97	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.68857355
98	Abnormality of alanine metabolism (HP:0010916)	1.68857355
99	Hyperalaninemia (HP:0003348)	1.68857355
100	Abnormality of the renal cortex (HP:0011035)	1.67350044

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.27501532
2	CASK	3.00334811
3	MAP2K7	2.96455467
4	STK16	2.95730843
5	MARK1	2.76602945
6	MAP3K4	2.71294108
7	WNK3	2.58673320
8	CDK19	2.54969549
9	BCR	2.52180514
10	DYRK2	2.48320815
11	TRIM28	2.44528806
12	TNIK	2.38178783
13	BCKDK	2.11780477
14	WNK4	1.74578708
15	EPHA4	1.74358881
16	MAPK13	1.68500249
17	NUAK1	1.66573852
18	CSNK1G2	1.65738961
19	PINK1	1.54898946
20	EPHB2	1.54178785
21	CSNK1G3	1.52099037
22	UHMK1	1.49135368
23	LIMK1	1.42477976
24	PAK3	1.41071735
25	PRKD3	1.40366820
26	TIE1	1.38354015
27	CSNK1A1L	1.34871877
28	NTRK2	1.32918883
29	PHKG1	1.30925205
30	PHKG2	1.30925205
31	ZAK	1.29517791
32	GRK1	1.26993704
33	CSNK1G1	1.26367389
34	ADRBK2	1.25122108
35	BMPR1B	1.24433399
36	MAP2K4	1.21695576
37	DYRK3	1.19032579
38	PRKCG	1.15410893
39	PLK2	1.05256483
40	MINK1	1.03865613
41	VRK2	0.98280842
42	NEK1	0.97779753
43	OXSR1	0.95796560
44	SGK494	0.95001562
45	SGK223	0.95001562
46	VRK1	0.92506069
47	RPS6KA4	0.91122601
48	DYRK1B	0.89460418
49	TAF1	0.87754917
50	CAMKK2	0.86575400
51	FRK	0.86092449
52	SRPK1	0.85857114
53	INSRR	0.83485191
54	EPHA3	0.83291924
55	PAK6	0.82042468
56	PRKCE	0.81873729
57	PIM2	0.81724170
58	ERBB3	0.80486158
59	DYRK1A	0.73307283
60	STK39	0.70422538
61	CAMK2A	0.69892481
62	CSNK1A1	0.69318389
63	CDK14	0.65910434
64	KSR1	0.65753311
65	CDC7	0.62993481
66	TLK1	0.61948155
67	MAPK15	0.61661559
68	PRKACA	0.61246347
69	PLK3	0.58007793
70	ARAF	0.56211551
71	CDK5	0.55983689
72	PLK4	0.55804768
73	ADRBK1	0.54687494
74	PRKCI	0.52922062
75	RPS6KA5	0.52887222
76	AURKA	0.51899872
77	PKN1	0.49805147
78	CDK11A	0.49146297
79	MAP3K9	0.49141538
80	CDK18	0.47564101
81	CAMK2B	0.47353500
82	PLK1	0.46899102
83	SGK2	0.46451202
84	NTRK3	0.44555104
85	CDK15	0.42851891
86	PRKCZ	0.42429074
87	CSNK1E	0.42018527
88	STK11	0.41309600
89	PRKG1	0.40974418
90	MAP3K12	0.40712466
91	CAMK1	0.39558081
92	PASK	0.37496288
93	GRK7	0.37448353
94	ATR	0.36556093
95	CAMK2D	0.35717837
96	CSNK2A1	0.34602352
97	EIF2AK3	0.34072793
98	AURKB	0.33648641
99	PRKACB	0.32605304
100	OBSCN	0.32423872

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.94579363
2	Parkinsons disease_Homo sapiens_hsa05012	3.36199648
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.95553740
4	Ribosome_Homo sapiens_hsa03010	2.85271696
5	Protein export_Homo sapiens_hsa03060	2.55967648
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.53765488
7	Nicotine addiction_Homo sapiens_hsa05033	2.35786068
8	Huntingtons disease_Homo sapiens_hsa05016	2.32124086
9	Cardiac muscle contraction_Homo sapiens_hsa04260	2.30280528
10	Alzheimers disease_Homo sapiens_hsa05010	2.22807330
11	Steroid biosynthesis_Homo sapiens_hsa00100	2.22708259
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.93467202
13	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.91400420
14	Butanoate metabolism_Homo sapiens_hsa00650	1.83647359
15	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.75250467
16	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.66413680
17	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.64628948
18	Phototransduction_Homo sapiens_hsa04744	1.47775170
19	GABAergic synapse_Homo sapiens_hsa04727	1.44635378
20	RNA polymerase_Homo sapiens_hsa03020	1.41825499
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.41497539
22	Propanoate metabolism_Homo sapiens_hsa00640	1.39095506
23	Collecting duct acid secretion_Homo sapiens_hsa04966	1.36776894
24	Sulfur relay system_Homo sapiens_hsa04122	1.31366560
25	Morphine addiction_Homo sapiens_hsa05032	1.28051594
26	RNA degradation_Homo sapiens_hsa03018	1.27102625
27	Basal transcription factors_Homo sapiens_hsa03022	1.26549568
28	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.24111029
29	Fanconi anemia pathway_Homo sapiens_hsa03460	1.22479397
30	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.18315830
31	Folate biosynthesis_Homo sapiens_hsa00790	1.17083475
32	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.14758411
33	Proteasome_Homo sapiens_hsa03050	1.13471178
34	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.09560481
35	Peroxisome_Homo sapiens_hsa04146	1.07824954
36	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.07824187
37	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.05266231
38	Homologous recombination_Homo sapiens_hsa03440	1.03963196
39	Mismatch repair_Homo sapiens_hsa03430	1.02181590
40	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.01999078
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.01747967
42	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.99710711
43	Fatty acid elongation_Homo sapiens_hsa00062	0.98158209
44	Arginine and proline metabolism_Homo sapiens_hsa00330	0.97510433
45	Linoleic acid metabolism_Homo sapiens_hsa00591	0.94432920
46	Basal cell carcinoma_Homo sapiens_hsa05217	0.91329691
47	Nitrogen metabolism_Homo sapiens_hsa00910	0.90380788
48	Pyruvate metabolism_Homo sapiens_hsa00620	0.89476742
49	Tryptophan metabolism_Homo sapiens_hsa00380	0.88087416
50	Nucleotide excision repair_Homo sapiens_hsa03420	0.87231785
51	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.86898315
52	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.85494505
53	beta-Alanine metabolism_Homo sapiens_hsa00410	0.83859207
54	Metabolic pathways_Homo sapiens_hsa01100	0.83365397
55	Dopaminergic synapse_Homo sapiens_hsa04728	0.82414646
56	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.80945016
57	Insulin secretion_Homo sapiens_hsa04911	0.80560220
58	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.80433282
59	Axon guidance_Homo sapiens_hsa04360	0.78966500
60	Pyrimidine metabolism_Homo sapiens_hsa00240	0.78462374
61	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.77620444
62	Regulation of autophagy_Homo sapiens_hsa04140	0.74417355
63	Glutamatergic synapse_Homo sapiens_hsa04724	0.73937782
64	Circadian entrainment_Homo sapiens_hsa04713	0.73854091
65	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.72909713
66	Taste transduction_Homo sapiens_hsa04742	0.70024217
67	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.69822140
68	Cocaine addiction_Homo sapiens_hsa05030	0.67570852
69	Fatty acid degradation_Homo sapiens_hsa00071	0.67353140
70	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.66837379
71	Carbon metabolism_Homo sapiens_hsa01200	0.65924393
72	Vibrio cholerae infection_Homo sapiens_hsa05110	0.64021130
73	Olfactory transduction_Homo sapiens_hsa04740	0.63313983
74	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.62735933
75	Base excision repair_Homo sapiens_hsa03410	0.62579310
76	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.62082854
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.61878171
78	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.61571485
79	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.61027131
80	Purine metabolism_Homo sapiens_hsa00230	0.59769274
81	Chemical carcinogenesis_Homo sapiens_hsa05204	0.59386550
82	Hippo signaling pathway_Homo sapiens_hsa04390	0.59270396
83	Retinol metabolism_Homo sapiens_hsa00830	0.57608565
84	Caffeine metabolism_Homo sapiens_hsa00232	0.56404764
85	Serotonergic synapse_Homo sapiens_hsa04726	0.56184635
86	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.54171856
87	Circadian rhythm_Homo sapiens_hsa04710	0.53203626
88	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.51440221
89	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.50897884
90	Ether lipid metabolism_Homo sapiens_hsa00565	0.50299879
91	Selenocompound metabolism_Homo sapiens_hsa00450	0.47339630
92	Alcoholism_Homo sapiens_hsa05034	0.43117506
93	Spliceosome_Homo sapiens_hsa03040	0.42911975
94	Galactose metabolism_Homo sapiens_hsa00052	0.42004001
95	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.39491456
96	Fat digestion and absorption_Homo sapiens_hsa04975	0.36315644
97	Glutathione metabolism_Homo sapiens_hsa00480	0.35085827
98	Wnt signaling pathway_Homo sapiens_hsa04310	0.34959563
99	Non-homologous end-joining_Homo sapiens_hsa03450	0.33808586
100	RNA transport_Homo sapiens_hsa03013	0.33138265

BNIP3P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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