ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	neural tube formation (GO:0001841)	4.98245659
2	peptidyl-cysteine modification (GO:0018198)	4.86808800
3	negative regulation of dendrite development (GO:2000171)	4.66707233
4	kinetochore organization (GO:0051383)	4.66123203
5	positive regulation of T cell cytokine production (GO:0002726)	4.43910989
6	kinetochore assembly (GO:0051382)	4.05345384
7	negative regulation of mast cell activation (GO:0033004)	3.96025835
8	platelet dense granule organization (GO:0060155)	3.93084780
9	regulation of neuron migration (GO:2001222)	3.92025499
10	purine nucleobase biosynthetic process (GO:0009113)	3.77882172
11	DNA double-strand break processing (GO:0000729)	3.63549586
12	cullin deneddylation (GO:0010388)	3.54719981
13	mitotic sister chromatid cohesion (GO:0007064)	3.47710704
14	histone H2A acetylation (GO:0043968)	3.44260038
15	opioid receptor signaling pathway (GO:0038003)	3.43545631
16	response to pheromone (GO:0019236)	3.41595414
17	meiotic chromosome segregation (GO:0045132)	3.39563909
18	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	3.37496682
19	nodal signaling pathway (GO:0038092)	3.36902014
20	aldehyde catabolic process (GO:0046185)	3.34073484
21	nucleobase biosynthetic process (GO:0046112)	3.32080633
22	anterograde synaptic vesicle transport (GO:0048490)	3.31114327
23	positive regulation of protein homodimerization activity (GO:0090073)	3.29373473
24	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.25421177
25	centriole replication (GO:0007099)	3.24102180
26	pericardium development (GO:0060039)	3.23016404
27	regulation of centriole replication (GO:0046599)	3.21624643
28	negative regulation of dendrite morphogenesis (GO:0050774)	3.20336186
29	chromatin remodeling at centromere (GO:0031055)	3.17037554
30	positive regulation of growth hormone secretion (GO:0060124)	3.15782208
31	epithelial cilium movement (GO:0003351)	3.14591804
32	acrosome assembly (GO:0001675)	3.08781192
33	prenylation (GO:0097354)	3.07752162
34	protein prenylation (GO:0018342)	3.07752162
35	somite rostral/caudal axis specification (GO:0032525)	3.03934458
36	signal peptide processing (GO:0006465)	3.01884762
37	glycosphingolipid biosynthetic process (GO:0006688)	3.00601464
38	regulation of heat generation (GO:0031650)	3.00353514
39	CENP-A containing nucleosome assembly (GO:0034080)	2.97816672
40	protein K6-linked ubiquitination (GO:0085020)	2.93749063
41	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	2.92073158
42	cilium morphogenesis (GO:0060271)	2.91652449
43	protein deneddylation (GO:0000338)	2.90915949
44	somite development (GO:0061053)	2.90809518
45	behavioral response to nicotine (GO:0035095)	2.90430256
46	negative regulation of DNA recombination (GO:0045910)	2.89898862
47	regulation of penile erection (GO:0060405)	2.88983103
48	DNA replication checkpoint (GO:0000076)	2.88034788
49	anterior/posterior axis specification, embryo (GO:0008595)	2.87676671
50	postreplication repair (GO:0006301)	2.86372167
51	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.84084328
52	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.83261559
53	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.82115835
54	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	2.81920756
55	regulation of chromatin silencing (GO:0031935)	2.80230441
56	histone exchange (GO:0043486)	2.80160858
57	regulation of T cell cytokine production (GO:0002724)	2.79915550
58	microtubule anchoring (GO:0034453)	2.79736438
59	histone mRNA catabolic process (GO:0071044)	2.79725223
60	regulation of helicase activity (GO:0051095)	2.79254479
61	nucleotide transmembrane transport (GO:1901679)	2.76694823
62	reciprocal meiotic recombination (GO:0007131)	2.76389179
63	reciprocal DNA recombination (GO:0035825)	2.76389179
64	IMP biosynthetic process (GO:0006188)	2.75486810
65	cholesterol biosynthetic process (GO:0006695)	2.74661608
66	neuron cell-cell adhesion (GO:0007158)	2.74126525
67	lactate metabolic process (GO:0006089)	2.72158105
68	otic vesicle formation (GO:0030916)	2.71718338
69	regulation of growth hormone secretion (GO:0060123)	2.69814113
70	L-serine transport (GO:0015825)	2.68181345
71	lipid particle organization (GO:0034389)	2.67922712
72	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.67265368
73	recombinational repair (GO:0000725)	2.66601090
74	regulation of cilium movement (GO:0003352)	2.66066710
75	DNA replication-dependent nucleosome assembly (GO:0006335)	2.65982549
76	DNA replication-dependent nucleosome organization (GO:0034723)	2.65982549
77	serotonin receptor signaling pathway (GO:0007210)	2.63463403
78	female gonad development (GO:0008585)	2.60275087
79	double-strand break repair via homologous recombination (GO:0000724)	2.57343644
80	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.55820623
81	vascular smooth muscle contraction (GO:0014829)	2.55722634
82	branched-chain amino acid catabolic process (GO:0009083)	2.55333037
83	sterol biosynthetic process (GO:0016126)	2.52973811
84	mitotic spindle checkpoint (GO:0071174)	2.52571694
85	regulation of fever generation (GO:0031620)	2.51007573
86	presynaptic membrane assembly (GO:0097105)	2.50594798
87	regulation of mesoderm development (GO:2000380)	2.50537117
88	response to nitrosative stress (GO:0051409)	2.49939181
89	melanosome transport (GO:0032402)	2.48820625
90	histone mRNA metabolic process (GO:0008334)	2.48435364
91	limb bud formation (GO:0060174)	2.48267486
92	spindle checkpoint (GO:0031577)	2.46847318
93	peroxisome fission (GO:0016559)	2.46209685
94	ventricular system development (GO:0021591)	2.46119013
95	DNA demethylation (GO:0080111)	2.45121152
96	negative regulation of catecholamine secretion (GO:0033604)	2.42669617
97	ncRNA catabolic process (GO:0034661)	2.42175451
98	pyrimidine nucleobase catabolic process (GO:0006208)	2.42115616
99	retinal cone cell development (GO:0046549)	2.41775672
100	positive regulation of glycoprotein metabolic process (GO:1903020)	2.40701232

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.76411909
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.47432155
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.32590670
4	VDR_22108803_ChIP-Seq_LS180_Human	3.20907540
5	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.01121399
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.73590833
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.66446549
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.65461652
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.62358986
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.37899260
11	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.37775540
12	P300_19829295_ChIP-Seq_ESCs_Human	2.35558746
13	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.33830459
14	FUS_26573619_Chip-Seq_HEK293_Human	2.24859220
15	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.23723611
16	GBX2_23144817_ChIP-Seq_PC3_Human	2.22914106
17	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.16774381
18	E2F7_22180533_ChIP-Seq_HELA_Human	2.16296386
19	TAF15_26573619_Chip-Seq_HEK293_Human	2.13282727
20	ELK1_19687146_ChIP-ChIP_HELA_Human	2.12382032
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.10036404
22	EWS_26573619_Chip-Seq_HEK293_Human	2.04703182
23	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.95212958
24	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.90528917
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.88775950
26	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.87477215
27	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.85553315
28	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.84159632
29	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.79333813
30	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.72209958
31	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.68137755
32	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.68137755
33	CBP_20019798_ChIP-Seq_JUKART_Human	1.67483457
34	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.67483457
35	BCAT_22108803_ChIP-Seq_LS180_Human	1.63050620
36	IRF1_19129219_ChIP-ChIP_H3396_Human	1.62632018
37	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.59406538
38	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.57616268
39	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.57057992
40	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.55909561
41	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.53490751
42	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.53399855
43	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.51555908
44	SMAD4_21799915_ChIP-Seq_A2780_Human	1.50957697
45	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.47955887
46	AR_25329375_ChIP-Seq_VCAP_Human	1.47411998
47	AR_21572438_ChIP-Seq_LNCaP_Human	1.45072457
48	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.44459651
49	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.43008764
50	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.41478518
51	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.39759604
52	MYC_18940864_ChIP-ChIP_HL60_Human	1.37498258
53	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.36461828
54	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.35656292
55	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.34761065
56	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.34605087
57	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.34516107
58	TCF4_23295773_ChIP-Seq_U87_Human	1.30476249
59	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.30073257
60	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.30000857
61	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.29449389
62	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.27850515
63	VDR_23849224_ChIP-Seq_CD4+_Human	1.25507671
64	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.23858334
65	STAT3_23295773_ChIP-Seq_U87_Human	1.22631702
66	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.21229801
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.21168408
68	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.21147553
69	ER_23166858_ChIP-Seq_MCF-7_Human	1.20899696
70	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.20768019
71	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.19249265
72	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.18348523
73	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.17123498
74	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.16044117
75	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.14307304
76	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.14288936
77	SOX2_19829295_ChIP-Seq_ESCs_Human	1.13820409
78	NANOG_19829295_ChIP-Seq_ESCs_Human	1.13820409
79	RUNX2_22187159_ChIP-Seq_PCA_Human	1.13456029
80	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.09926026
81	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.09772137
82	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.08355881
83	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.08340892
84	EZH2_22144423_ChIP-Seq_EOC_Human	1.07987717
85	P300_18555785_Chip-Seq_ESCs_Mouse	1.07611255
86	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.06677186
87	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.06446450
88	P53_22387025_ChIP-Seq_ESCs_Mouse	1.05656222
89	FOXP3_21729870_ChIP-Seq_TREG_Human	1.05356065
90	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.02714292
91	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.99612752
92	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.99418913
93	TCF4_22108803_ChIP-Seq_LS180_Human	0.98489665
94	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.97565352
95	TP53_22573176_ChIP-Seq_HFKS_Human	0.97510777
96	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.97509110
97	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.97381774
98	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.96165452
99	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.95519067
100	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.94061727

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002822_catalepsy	5.30864353
2	MP0002102_abnormal_ear_morphology	4.12494774
3	MP0003890_abnormal_embryonic-extraembry	3.28087330
4	MP0008877_abnormal_DNA_methylation	2.98920497
5	MP0002837_dystrophic_cardiac_calcinosis	2.97952976
6	MP0003195_calcinosis	2.61666966
7	MP0003787_abnormal_imprinting	2.59617821
8	MP0006292_abnormal_olfactory_placode	2.35663612
9	MP0001984_abnormal_olfaction	2.22038017
10	MP0010094_abnormal_chromosome_stability	1.98763505
11	MP0005499_abnormal_olfactory_system	1.94263351
12	MP0005394_taste/olfaction_phenotype	1.94263351
13	MP0005310_abnormal_salivary_gland	1.91187821
14	MP0003937_abnormal_limbs/digits/tail_de	1.86718475
15	MP0004133_heterotaxia	1.82618953
16	MP0003119_abnormal_digestive_system	1.81799822
17	MP0004957_abnormal_blastocyst_morpholog	1.81541217
18	MP0002928_abnormal_bile_duct	1.79226044
19	MP0003283_abnormal_digestive_organ	1.72676103
20	MP0009697_abnormal_copulation	1.69063942
21	MP0003136_yellow_coat_color	1.68888122
22	MP0008932_abnormal_embryonic_tissue	1.65981489
23	MP0001177_atelectasis	1.63795614
24	MP0004381_abnormal_hair_follicle	1.52197770
25	MP0003880_abnormal_central_pattern	1.50767686
26	MP0008058_abnormal_DNA_repair	1.47750074
27	MP0002233_abnormal_nose_morphology	1.47174955
28	MP0003693_abnormal_embryo_hatching	1.46293050
29	MP0005551_abnormal_eye_electrophysiolog	1.44179849
30	MP0003252_abnormal_bile_duct	1.43884737
31	MP0003077_abnormal_cell_cycle	1.43629931
32	MP0000427_abnormal_hair_cycle	1.43145475
33	MP0002751_abnormal_autonomic_nervous	1.42839466
34	MP0002254_reproductive_system_inflammat	1.40290024
35	MP0008789_abnormal_olfactory_epithelium	1.36530302
36	MP0001293_anophthalmia	1.33816402
37	MP0001346_abnormal_lacrimal_gland	1.33547372
38	MP0010030_abnormal_orbit_morphology	1.32348426
39	MP0000778_abnormal_nervous_system	1.32276981
40	MP0002638_abnormal_pupillary_reflex	1.32143093
41	MP0004215_abnormal_myocardial_fiber	1.31485386
42	MP0005174_abnormal_tail_pigmentation	1.29597889
43	MP0001299_abnormal_eye_distance/	1.29304292
44	MP0003121_genomic_imprinting	1.28669939
45	MP0003122_maternal_imprinting	1.26388684
46	MP0005253_abnormal_eye_physiology	1.25447384
47	MP0003718_maternal_effect	1.24520709
48	MP0009703_decreased_birth_body	1.20209972
49	MP0008775_abnormal_heart_ventricle	1.19203761
50	MP0002736_abnormal_nociception_after	1.17079649
51	MP0000569_abnormal_digit_pigmentation	1.15509350
52	MP0001286_abnormal_eye_development	1.15298270
53	MP0004145_abnormal_muscle_electrophysio	1.12604842
54	MP0000647_abnormal_sebaceous_gland	1.12415714
55	MP0006072_abnormal_retinal_apoptosis	1.11795535
56	MP0001324_abnormal_eye_pigmentation	1.11230520
57	MP0005075_abnormal_melanosome_morpholog	1.10625250
58	MP0000631_abnormal_neuroendocrine_gland	1.10110133
59	MP0002876_abnormal_thyroid_physiology	1.08710960
60	MP0005408_hypopigmentation	1.08228675
61	MP0002734_abnormal_mechanical_nocicepti	1.08227564
62	MP0002735_abnormal_chemical_nociception	1.07892420
63	MP0005220_abnormal_exocrine_pancreas	1.06380824
64	MP0002084_abnormal_developmental_patter	1.05241146
65	MP0003567_abnormal_fetal_cardiomyocyte	1.05237491
66	MP0002138_abnormal_hepatobiliary_system	1.04829525
67	MP0001529_abnormal_vocalization	1.03545681
68	MP0004270_analgesia	1.03066034
69	MP0003938_abnormal_ear_development	0.98652805
70	MP0003755_abnormal_palate_morphology	0.98627544
71	MP0000372_irregular_coat_pigmentation	0.98256412
72	MP0002938_white_spotting	0.95359634
73	MP0003935_abnormal_craniofacial_develop	0.95208547
74	MP0004085_abnormal_heartbeat	0.94651654
75	MP0005367_renal/urinary_system_phenotyp	0.90021110
76	MP0000516_abnormal_urinary_system	0.90021110
77	MP0001486_abnormal_startle_reflex	0.88202045
78	MP0001968_abnormal_touch/_nociception	0.86105790
79	MP0004885_abnormal_endolymph	0.85373397
80	MP0005386_behavior/neurological_phenoty	0.84266408
81	MP0004924_abnormal_behavior	0.84266408
82	MP0001970_abnormal_pain_threshold	0.83041560
83	MP0002085_abnormal_embryonic_tissue	0.82734492
84	MP0002163_abnormal_gland_morphology	0.81585601
85	MP0003943_abnormal_hepatobiliary_system	0.80691308
86	MP0003111_abnormal_nucleus_morphology	0.80548436
87	MP0004742_abnormal_vestibular_system	0.79344179
88	MP0009745_abnormal_behavioral_response	0.78782288
89	MP0005391_vision/eye_phenotype	0.78546895
90	MP0001963_abnormal_hearing_physiology	0.76560382
91	MP0008770_decreased_survivor_rate	0.75767347
92	MP0004142_abnormal_muscle_tone	0.75516237
93	MP0001485_abnormal_pinna_reflex	0.75330405
94	MP0003861_abnormal_nervous_system	0.74913767
95	MP0002009_preneoplasia	0.74451709
96	MP0005084_abnormal_gallbladder_morpholo	0.73504244
97	MP0002277_abnormal_respiratory_mucosa	0.72949085
98	MP0008057_abnormal_DNA_replication	0.71653167
99	MP0002111_abnormal_tail_morphology	0.71524048
100	MP0005195_abnormal_posterior_eye	0.71362441

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Intestinal atresia (HP:0011100)	5.33164508
2	Bifid tongue (HP:0010297)	3.75634210
3	Supernumerary spleens (HP:0009799)	3.58632988
4	Volvulus (HP:0002580)	3.42434238
5	Pancreatic islet-cell hyperplasia (HP:0004510)	3.24318899
6	Large for gestational age (HP:0001520)	3.05314249
7	Broad alveolar ridges (HP:0000187)	3.03591139
8	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.92899814
9	3-Methylglutaconic aciduria (HP:0003535)	2.87493727
10	Abnormality of the labia minora (HP:0012880)	2.87069027
11	Pancreatic cysts (HP:0001737)	2.84387579
12	Abnormality of the ileum (HP:0001549)	2.76033006
13	Broad-based gait (HP:0002136)	2.75113543
14	Epidermoid cyst (HP:0200040)	2.74687174
15	Nephroblastoma (Wilms tumor) (HP:0002667)	2.71142110
16	Embryonal renal neoplasm (HP:0011794)	2.65421977
17	Molar tooth sign on MRI (HP:0002419)	2.57205325
18	Abnormality of midbrain morphology (HP:0002418)	2.57205325
19	Chromsome breakage (HP:0040012)	2.51057106
20	Stenosis of the external auditory canal (HP:0000402)	2.49948235
21	Hepatoblastoma (HP:0002884)	2.47738908
22	Horseshoe kidney (HP:0000085)	2.45490498
23	Abnormality of chromosome stability (HP:0003220)	2.40689443
24	Methylmalonic acidemia (HP:0002912)	2.40312200
25	Gastrointestinal atresia (HP:0002589)	2.39065190
26	True hermaphroditism (HP:0010459)	2.37132056
27	Pancreatic fibrosis (HP:0100732)	2.33858172
28	Abnormal lung lobation (HP:0002101)	2.31171965
29	Increased circulating renin level (HP:0000848)	2.27059296
30	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.23985958
31	Tented upper lip vermilion (HP:0010804)	2.20800541
32	Thickened helices (HP:0000391)	2.17985395
33	Meckel diverticulum (HP:0002245)	2.17188319
34	Hyperventilation (HP:0002883)	2.14995359
35	Chronic hepatic failure (HP:0100626)	2.12412423
36	Decreased muscle mass (HP:0003199)	2.09903280
37	Oligodactyly (hands) (HP:0001180)	2.09180851
38	Rimmed vacuoles (HP:0003805)	2.05591659
39	Septo-optic dysplasia (HP:0100842)	2.03103965
40	Cortical dysplasia (HP:0002539)	2.00046692
41	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.98740376
42	Cupped ear (HP:0000378)	1.96111810
43	Aqueductal stenosis (HP:0002410)	1.95708091
44	Abnormality of the musculature of the pelvis (HP:0001469)	1.94210003
45	Abnormality of the hip-girdle musculature (HP:0001445)	1.94210003
46	Abnormality of methionine metabolism (HP:0010901)	1.93616998
47	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.93097355
48	Exercise-induced muscle cramps (HP:0003710)	1.92655365
49	Optic nerve hypoplasia (HP:0000609)	1.92087279
50	Meningioma (HP:0002858)	1.91988975
51	Amblyopia (HP:0000646)	1.91234498
52	Sloping forehead (HP:0000340)	1.90136406
53	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.89646236
54	Abnormality of the duodenum (HP:0002246)	1.89455332
55	Type I transferrin isoform profile (HP:0003642)	1.88606873
56	Anencephaly (HP:0002323)	1.88352227
57	Long nose (HP:0003189)	1.87752384
58	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.87606028
59	Preaxial foot polydactyly (HP:0001841)	1.85429199
60	Absent radius (HP:0003974)	1.84864355
61	Growth hormone deficiency (HP:0000824)	1.84772051
62	Thin upper lip vermilion (HP:0000219)	1.84186521
63	Genital tract atresia (HP:0001827)	1.83801463
64	Neoplasm of the adrenal gland (HP:0100631)	1.83629130
65	Small intestinal stenosis (HP:0012848)	1.83562988
66	Duodenal stenosis (HP:0100867)	1.83562988
67	Shoulder girdle muscle weakness (HP:0003547)	1.78105798
68	Vaginal atresia (HP:0000148)	1.77689368
69	Attenuation of retinal blood vessels (HP:0007843)	1.77626935
70	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.76593476
71	Abnormal hair whorl (HP:0010721)	1.75096884
72	Absent eyebrow (HP:0002223)	1.75096140
73	Nausea (HP:0002018)	1.73245313
74	Hypoplastic female external genitalia (HP:0012815)	1.72751341
75	Abnormality of the pancreatic islet cells (HP:0006476)	1.72500681
76	Abnormality of endocrine pancreas physiology (HP:0012093)	1.72500681
77	Hip dysplasia (HP:0001385)	1.70185835
78	Renal hypoplasia (HP:0000089)	1.69643787
79	Absent forearm bone (HP:0003953)	1.69530822
80	Aplasia involving forearm bones (HP:0009822)	1.69530822
81	Papillary thyroid carcinoma (HP:0002895)	1.69007734
82	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.67199457
83	Polyphagia (HP:0002591)	1.67077042
84	Broad foot (HP:0001769)	1.67024298
85	Short tibia (HP:0005736)	1.66820265
86	Narrow forehead (HP:0000341)	1.65718644
87	Shawl scrotum (HP:0000049)	1.65254354
88	Abnormality of the preputium (HP:0100587)	1.64738384
89	Labial hypoplasia (HP:0000066)	1.64486814
90	Medial flaring of the eyebrow (HP:0010747)	1.64434646
91	Hypoplastic pelvis (HP:0008839)	1.64360175
92	Abnormality of serine family amino acid metabolism (HP:0010894)	1.64351468
93	Abnormality of glycine metabolism (HP:0010895)	1.64351468
94	Embryonal neoplasm (HP:0002898)	1.63121549
95	Decreased central vision (HP:0007663)	1.62985488
96	Abnormality of the labia (HP:0000058)	1.62868165
97	Postaxial hand polydactyly (HP:0001162)	1.61751027
98	Abolished electroretinogram (ERG) (HP:0000550)	1.61486508
99	Chorioretinal coloboma (HP:0000567)	1.60875464
100	Furrowed tongue (HP:0000221)	1.60351883

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ACVR1B	4.65091998
2	ADRBK2	3.62621322
3	FRK	3.35525962
4	TNIK	3.33605193
5	BRD4	3.23643237
6	WNK3	2.91197099
7	CASK	2.78309173
8	MKNK2	2.67618278
9	CDK19	2.20600882
10	AKT3	2.20508442
11	BMPR1B	2.20265388
12	MKNK1	2.15313159
13	STK38L	1.98598865
14	OXSR1	1.92916102
15	EIF2AK3	1.90812308
16	TRIM28	1.79545442
17	NEK1	1.64142754
18	ERBB3	1.62804620
19	WNK4	1.61876322
20	ERBB4	1.60684218
21	STK39	1.57924568
22	PKN2	1.53043189
23	PLK4	1.49401397
24	TSSK6	1.47046693
25	TLK1	1.46297069
26	MAP3K4	1.42160791
27	BUB1	1.39225025
28	NLK	1.31414575
29	SRPK1	1.30158096
30	BCR	1.25446727
31	MAPK13	1.25277563
32	FGR	1.23204638
33	FGFR2	1.21942104
34	PLK3	1.20760636
35	WEE1	1.19936059
36	BRSK2	1.18354855
37	SIK2	1.16676721
38	ZAK	1.13910949
39	PBK	1.13504408
40	FLT3	1.07411826
41	SGK2	1.04867924
42	PRKD3	1.01026220
43	CAMKK2	1.00576843
44	PASK	0.97291342
45	PINK1	0.95657167
46	MAP3K10	0.90815108
47	DYRK2	0.90298453
48	CDC7	0.89298802
49	PLK2	0.82452348
50	TGFBR1	0.78103981
51	PNCK	0.75920626
52	PLK1	0.74872656
53	MAP4K2	0.74648727
54	MAP2K7	0.73937352
55	ATR	0.72213972
56	SGK494	0.72181193
57	SGK223	0.72181193
58	OBSCN	0.71755221
59	GRK1	0.69223055
60	TYRO3	0.67708490
61	EPHA3	0.67654509
62	MARK1	0.66904218
63	ADRBK1	0.64164787
64	PAK3	0.63517316
65	MAP3K7	0.63035711
66	PTK2B	0.62992201
67	PKN1	0.60820949
68	TTK	0.60033377
69	PDK2	0.58248640
70	VRK1	0.54974889
71	EIF2AK1	0.54918937
72	DYRK3	0.54875604
73	MST4	0.53198957
74	ATM	0.52781027
75	PRKCZ	0.52575449
76	CHEK2	0.52172867
77	PRKCG	0.50964660
78	PRKCE	0.46489177
79	NEK6	0.46301238
80	STK3	0.44330265
81	CAMK1D	0.42452785
82	MELK	0.41145190
83	CHEK1	0.38502339
84	NUAK1	0.37046754
85	MUSK	0.36852094
86	LIMK1	0.35679930
87	PRKCH	0.35581498
88	CDK8	0.35246851
89	MATK	0.29605166
90	DYRK1A	0.29495061
91	STK24	0.29012726
92	PRKDC	0.28657460
93	FGFR1	0.26416694
94	INSRR	0.25575620
95	RPS6KA5	0.25086464
96	RPS6KA4	0.23086509
97	PRKCQ	0.22503769
98	BRAF	0.22135197
99	EIF2AK2	0.20530498
100	CAMK2A	0.20526439

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.88745322
2	Steroid biosynthesis_Homo sapiens_hsa00100	3.84075904
3	Propanoate metabolism_Homo sapiens_hsa00640	3.67805565
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.61537303
5	Butanoate metabolism_Homo sapiens_hsa00650	2.68280959
6	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.59375027
7	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.55908492
8	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	2.51791869
9	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.45404898
10	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.43565131
11	Non-homologous end-joining_Homo sapiens_hsa03450	2.42608762
12	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.32601934
13	Basal transcription factors_Homo sapiens_hsa03022	2.31450904
14	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.15571860
15	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.03814284
16	Proteasome_Homo sapiens_hsa03050	2.03310929
17	RNA degradation_Homo sapiens_hsa03018	1.94526667
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.84487472
19	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.79839642
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.60881363
21	RNA transport_Homo sapiens_hsa03013	1.53206035
22	Phototransduction_Homo sapiens_hsa04744	1.47130644
23	DNA replication_Homo sapiens_hsa03030	1.37929879
24	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.32771615
25	beta-Alanine metabolism_Homo sapiens_hsa00410	1.32304411
26	Homologous recombination_Homo sapiens_hsa03440	1.30353096
27	Oxidative phosphorylation_Homo sapiens_hsa00190	1.19608109
28	RNA polymerase_Homo sapiens_hsa03020	1.19512707
29	Cell cycle_Homo sapiens_hsa04110	1.18070493
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.11745723
31	Fatty acid degradation_Homo sapiens_hsa00071	1.11119759
32	Pyruvate metabolism_Homo sapiens_hsa00620	1.09040296
33	Mismatch repair_Homo sapiens_hsa03430	1.08571084
34	Fatty acid metabolism_Homo sapiens_hsa01212	1.08482002
35	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.04124390
36	Fatty acid elongation_Homo sapiens_hsa00062	1.01970117
37	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.00855173
38	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.96359135
39	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.95626646
40	Parkinsons disease_Homo sapiens_hsa05012	0.94987968
41	Spliceosome_Homo sapiens_hsa03040	0.94564378
42	Taste transduction_Homo sapiens_hsa04742	0.93890244
43	Selenocompound metabolism_Homo sapiens_hsa00450	0.93834494
44	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.92724191
45	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.91538891
46	Olfactory transduction_Homo sapiens_hsa04740	0.91487398
47	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.87359059
48	Carbon metabolism_Homo sapiens_hsa01200	0.86293000
49	Nicotine addiction_Homo sapiens_hsa05033	0.85280081
50	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.83900152
51	Caffeine metabolism_Homo sapiens_hsa00232	0.83765259
52	Peroxisome_Homo sapiens_hsa04146	0.83181333
53	Alzheimers disease_Homo sapiens_hsa05010	0.82647196
54	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.78902777
55	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.76564247
56	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.76456426
57	p53 signaling pathway_Homo sapiens_hsa04115	0.76038625
58	Basal cell carcinoma_Homo sapiens_hsa05217	0.75075298
59	Fat digestion and absorption_Homo sapiens_hsa04975	0.72543235
60	Oocyte meiosis_Homo sapiens_hsa04114	0.72367423
61	Collecting duct acid secretion_Homo sapiens_hsa04966	0.71325193
62	Huntingtons disease_Homo sapiens_hsa05016	0.69682139
63	Alcoholism_Homo sapiens_hsa05034	0.67608970
64	Purine metabolism_Homo sapiens_hsa00230	0.62310057
65	Lysine degradation_Homo sapiens_hsa00310	0.62276695
66	One carbon pool by folate_Homo sapiens_hsa00670	0.59743098
67	Nucleotide excision repair_Homo sapiens_hsa03420	0.59697899
68	Wnt signaling pathway_Homo sapiens_hsa04310	0.59113436
69	mRNA surveillance pathway_Homo sapiens_hsa03015	0.57730579
70	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.57713551
71	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.57236875
72	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.52473217
73	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.52120678
74	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.51590134
75	Glycerolipid metabolism_Homo sapiens_hsa00561	0.49003270
76	Metabolic pathways_Homo sapiens_hsa01100	0.48616999
77	Hippo signaling pathway_Homo sapiens_hsa04390	0.44115656
78	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.43115119
79	Colorectal cancer_Homo sapiens_hsa05210	0.41525518
80	Adherens junction_Homo sapiens_hsa04520	0.40116801
81	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.38701344
82	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.38556897
83	Base excision repair_Homo sapiens_hsa03410	0.35706694
84	Tyrosine metabolism_Homo sapiens_hsa00350	0.34680204
85	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.34440276
86	Ether lipid metabolism_Homo sapiens_hsa00565	0.33888856
87	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.30784401
88	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.30149297
89	Pyrimidine metabolism_Homo sapiens_hsa00240	0.29921719
90	Circadian rhythm_Homo sapiens_hsa04710	0.28300889
91	Legionellosis_Homo sapiens_hsa05134	0.27302612
92	Serotonergic synapse_Homo sapiens_hsa04726	0.25819362
93	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.25610505
94	Linoleic acid metabolism_Homo sapiens_hsa00591	0.25469686
95	Dopaminergic synapse_Homo sapiens_hsa04728	0.24984903
96	Circadian entrainment_Homo sapiens_hsa04713	0.23640833
97	Calcium signaling pathway_Homo sapiens_hsa04020	0.21790820
98	Retinol metabolism_Homo sapiens_hsa00830	0.21584177
99	Regulation of autophagy_Homo sapiens_hsa04140	0.20201440
100	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.19673691

BNIP3P10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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