BNIP3P11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.59356883
2regulation of gamma-delta T cell differentiation (GO:0045586)4.71164058
3dosage compensation (GO:0007549)4.65076613
4regulation of gamma-delta T cell activation (GO:0046643)4.31859322
5negative regulation of histone methylation (GO:0031061)4.29325128
6B cell receptor signaling pathway (GO:0050853)4.17668149
7regulation of histone H3-K9 methylation (GO:0051570)4.13587241
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.93416261
9regulation of meiosis I (GO:0060631)3.93103370
10regulation of B cell receptor signaling pathway (GO:0050855)3.78769667
11nuclear pore complex assembly (GO:0051292)3.78477740
12nuclear pore organization (GO:0006999)3.78106425
13positive regulation of humoral immune response (GO:0002922)3.73343482
14embryonic process involved in female pregnancy (GO:0060136)3.70705160
15positive regulation of granulocyte differentiation (GO:0030854)3.68348872
16histone H3-K36 demethylation (GO:0070544)3.51533404
17negative thymic T cell selection (GO:0045060)3.43725745
18regulation of B cell differentiation (GO:0045577)3.41351769
19positive regulation of B cell differentiation (GO:0045579)3.35455085
20negative T cell selection (GO:0043383)3.35325113
21regulation of DNA methylation (GO:0044030)3.28386217
22histone H3-K9 modification (GO:0061647)3.27037745
23histone H3-K9 methylation (GO:0051567)3.22330735
24piRNA metabolic process (GO:0034587)3.18162757
25positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.17744122
26neutrophil activation involved in immune response (GO:0002283)3.17682940
27mitotic chromosome condensation (GO:0007076)3.15244685
28regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.14741035
29B cell proliferation (GO:0042100)3.07781478
30histone lysine demethylation (GO:0070076)3.00769650
31peptidyl-lysine dimethylation (GO:0018027)2.98936825
32histone demethylation (GO:0016577)2.98099773
33positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.96931142
34thymic T cell selection (GO:0045061)2.93680116
35regulation of histone methylation (GO:0031060)2.93399922
36positive regulation of isotype switching (GO:0045830)2.91820913
37regulation of granulocyte differentiation (GO:0030852)2.90575693
38negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.90139438
39negative regulation of cell killing (GO:0031342)2.90139438
40positive thymic T cell selection (GO:0045059)2.89168131
413-UTR-mediated mRNA stabilization (GO:0070935)2.87898812
42sister chromatid cohesion (GO:0007062)2.83308522
43B cell homeostasis (GO:0001782)2.82959806
44T cell homeostasis (GO:0043029)2.81060162
45positive regulation of interleukin-2 production (GO:0032743)2.78776921
46production of molecular mediator involved in inflammatory response (GO:0002532)2.76206102
47positive regulation of B cell activation (GO:0050871)2.75714353
48leukocyte aggregation (GO:0070486)2.75015844
49pore complex assembly (GO:0046931)2.74261459
50T cell selection (GO:0045058)2.72058027
51mitotic sister chromatid cohesion (GO:0007064)2.71149124
52neutrophil activation (GO:0042119)2.70204175
53positive regulation of B cell proliferation (GO:0030890)2.70010284
54response to peptidoglycan (GO:0032494)2.68511917
55gonadal mesoderm development (GO:0007506)2.67005082
56protein dealkylation (GO:0008214)2.65586539
57protein demethylation (GO:0006482)2.65586539
58positive regulation of DNA recombination (GO:0045911)2.65583254
59lymphocyte homeostasis (GO:0002260)2.64424536
60regulation of chromatin binding (GO:0035561)2.64166632
61G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.63039920
62regulation of interferon-beta biosynthetic process (GO:0045357)2.63026486
63monoubiquitinated protein deubiquitination (GO:0035520)2.62252004
64positive regulation by symbiont of host defense response (GO:0052509)2.59761543
65modulation by symbiont of host defense response (GO:0052031)2.59761543
66modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.59761543
67modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.59761543
68positive regulation by organism of defense response of other organism involved in symbiotic interact2.59761543
69modulation by symbiont of host immune response (GO:0052553)2.59761543
70regulation of B cell proliferation (GO:0030888)2.58931388
71N-terminal protein amino acid acetylation (GO:0006474)2.56787297
72regulation of histone H3-K27 methylation (GO:0061085)2.56631975
73negative regulation of meiosis (GO:0045835)2.56582530
74peptidyl-lysine trimethylation (GO:0018023)2.56345822
75histone H3-K9 demethylation (GO:0033169)2.53611578
76gene silencing by RNA (GO:0031047)2.52991655
77regulation of fibroblast apoptotic process (GO:2000269)2.52617144
78negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.52555876
79negative regulation of T-helper cell differentiation (GO:0045623)2.52555876
80negative regulation of T cell mediated immunity (GO:0002710)2.51549341
81antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.50484264
82hepatocyte apoptotic process (GO:0097284)2.50458578
83V(D)J recombination (GO:0033151)2.49910634
84positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.49405449
85immunoglobulin mediated immune response (GO:0016064)2.48067925
86defense response to protozoan (GO:0042832)2.47318049
87germinal center formation (GO:0002467)2.44442444
88regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.42864812
89leukocyte homeostasis (GO:0001776)2.42640696
90antigen receptor-mediated signaling pathway (GO:0050851)2.42537607
91B cell activation (GO:0042113)2.42403341
92B cell differentiation (GO:0030183)2.42383112
93histone monoubiquitination (GO:0010390)2.42094168
94positive regulation of histone H3-K4 methylation (GO:0051571)2.42080195
95positive regulation of interferon-alpha production (GO:0032727)2.41739595
96positive T cell selection (GO:0043368)2.41705421
97granulocyte activation (GO:0036230)2.41608944
98histone H3-K4 methylation (GO:0051568)2.41063581
99regulation of female gonad development (GO:2000194)2.41001191
100nuclear envelope disassembly (GO:0051081)2.39751209

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.20705676
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.16497540
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.78274279
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.61196261
5MYC_22102868_ChIP-Seq_BL_Human3.60520302
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.46265153
7NOTCH1_21737748_ChIP-Seq_TLL_Human2.72442367
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.56110183
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.54401187
10RUNX_20019798_ChIP-Seq_JUKART_Human2.51948290
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.51909928
12MYB_26560356_Chip-Seq_TH1_Human2.51463362
13MYB_26560356_Chip-Seq_TH2_Human2.50233850
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.31863862
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.30324504
16ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.25352065
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.24696507
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.16343311
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.16280136
20E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.14914289
21CIITA_25753668_ChIP-Seq_RAJI_Human2.14429431
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.14059948
23KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.14030348
24KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.14030348
25KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.14030348
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.11597230
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.07253395
28SPI1_23547873_ChIP-Seq_NB4_Human2.06843299
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.06220097
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03451594
31MAF_26560356_Chip-Seq_TH1_Human2.01520512
32UTX_26944678_Chip-Seq_JUKART_Human2.00296404
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.96010921
34VDR_21846776_ChIP-Seq_THP-1_Human1.94755360
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.92758755
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.92705238
37TFEB_21752829_ChIP-Seq_HELA_Human1.79758589
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.79419316
39IRF8_27001747_Chip-Seq_BMDM_Mouse1.77302485
40IRF8_21731497_ChIP-ChIP_J774_Mouse1.76115885
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.73195735
42VDR_24763502_ChIP-Seq_THP-1_Human1.71711954
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.70475095
44SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.70048288
45VDR_23849224_ChIP-Seq_CD4+_Human1.69476580
46GATA3_27048872_Chip-Seq_THYMUS_Human1.68108372
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.67038816
48TCF7_22412390_ChIP-Seq_EML_Mouse1.64948318
49FOXP3_21729870_ChIP-Seq_TREG_Human1.63634120
50MAF_26560356_Chip-Seq_TH2_Human1.59904125
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55509166
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50292265
53KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.47235807
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.46217887
55SCL_19346495_ChIP-Seq_HPC-7_Human1.44468407
56FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.43390825
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42545663
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37532985
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33062846
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.30539760
61TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30161657
62STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.29284005
63CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.28869667
64PKCTHETA_26484144_Chip-Seq_BREAST_Human1.27908641
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27857306
66DCP1A_22483619_ChIP-Seq_HELA_Human1.25160534
67RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23907349
68KDM5A_27292631_Chip-Seq_BREAST_Human1.22783105
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20032571
70GATA3_26560356_Chip-Seq_TH2_Human1.18763313
71TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17828230
72PU_27001747_Chip-Seq_BMDM_Mouse1.17076523
73E2F1_21310950_ChIP-Seq_MCF-7_Human1.16180036
74MYCN_18555785_ChIP-Seq_MESCs_Mouse1.13072825
75EST1_17652178_ChIP-ChIP_JURKAT_Human1.13058823
76KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.11353299
77PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10543886
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10269083
79SPI1_23127762_ChIP-Seq_K562_Human1.10258765
80VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09337840
81NCOR1_26117541_ChIP-Seq_K562_Human1.05602436
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04221962
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04118064
84CREB1_15753290_ChIP-ChIP_HEK293T_Human1.01475426
85CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01362025
86MYC_19079543_ChIP-ChIP_MESCs_Mouse0.98016104
87BP1_19119308_ChIP-ChIP_Hs578T_Human0.97958119
88Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97473745
89KDM2B_26808549_Chip-Seq_DND41_Human0.94650098
90SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.94485030
91CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94183959
92NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94047516
93DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93850814
94ETS1_22383799_ChIP-Seq_G1ME_Mouse0.93612020
95PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91506659
96PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88069015
97BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.88010489
98KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87573315
99GATA3_26560356_Chip-Seq_TH1_Human0.86842824
100FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85540153

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.45469673
2MP0001835_abnormal_antigen_presentation3.44040919
3MP0003763_abnormal_thymus_physiology3.36207092
4MP0002396_abnormal_hematopoietic_system3.10822787
5MP0001800_abnormal_humoral_immune2.81886095
6MP0005000_abnormal_immune_tolerance2.60753859
7MP0008877_abnormal_DNA_methylation2.60709521
8MP0003436_decreased_susceptibility_to2.49602679
9MP0005671_abnormal_response_to2.41500841
10MP0002009_preneoplasia2.37910998
11MP0000685_abnormal_immune_system2.37456105
12MP0002398_abnormal_bone_marrow2.34657204
13MP0002420_abnormal_adaptive_immunity2.23301538
14MP0002723_abnormal_immune_serum2.20335461
15MP0001819_abnormal_immune_cell2.18048273
16MP0002452_abnormal_antigen_presenting2.17639574
17MP0000703_abnormal_thymus_morphology2.08092718
18MP0010094_abnormal_chromosome_stability2.07287235
19MP0003303_peritoneal_inflammation2.06254351
20MP0001790_abnormal_immune_system2.02876786
21MP0005387_immune_system_phenotype2.02876786
22MP0004808_abnormal_hematopoietic_stem2.00458224
23MP0001873_stomach_inflammation1.98938584
24MP0000689_abnormal_spleen_morphology1.95990823
25MP0000716_abnormal_immune_system1.93392190
26MP0002166_altered_tumor_susceptibility1.91618911
27MP0000465_gastrointestinal_hemorrhage1.90898673
28MP0009278_abnormal_bone_marrow1.90728623
29MP0003724_increased_susceptibility_to1.89446049
30MP0002722_abnormal_immune_system1.86085179
31MP0003718_maternal_effect1.83746135
32MP0005464_abnormal_platelet_physiology1.82199407
33MP0003183_abnormal_peptide_metabolism1.82151604
34MP0005075_abnormal_melanosome_morpholog1.76385191
35MP0003111_abnormal_nucleus_morphology1.72702333
36MP0002138_abnormal_hepatobiliary_system1.70894462
37MP0004947_skin_inflammation1.69322871
38MP0002419_abnormal_innate_immunity1.66983423
39MP0003693_abnormal_embryo_hatching1.66663563
40MP0002132_abnormal_respiratory_system1.65826133
41MP0010155_abnormal_intestine_physiology1.65553693
42MP0005025_abnormal_response_to1.65263583
43MP0004381_abnormal_hair_follicle1.64436243
44MP0002429_abnormal_blood_cell1.63681680
45MP0002148_abnormal_hypersensitivity_rea1.62949612
46MP0003077_abnormal_cell_cycle1.55569319
47MP0003656_abnormal_erythrocyte_physiolo1.53738029
48MP0003300_gastrointestinal_ulcer1.51315905
49MP0003172_abnormal_lysosome_physiology1.49366610
50MP0002006_tumorigenesis1.42377811
51MP0001545_abnormal_hematopoietic_system1.42219007
52MP0005397_hematopoietic_system_phenotyp1.42219007
53MP0002405_respiratory_system_inflammati1.40193700
54MP0008058_abnormal_DNA_repair1.37658833
55MP0002019_abnormal_tumor_incidence1.33670626
56MP0005310_abnormal_salivary_gland1.25059178
57MP0001853_heart_inflammation1.24999625
58MP0001845_abnormal_inflammatory_respons1.20351690
59MP0009333_abnormal_splenocyte_physiolog1.17389121
60MP0009785_altered_susceptibility_to1.16913031
61MP0005451_abnormal_body_composition1.16337287
62MP0002877_abnormal_melanocyte_morpholog1.14254831
63MP0000490_abnormal_crypts_of1.07708944
64MP0003252_abnormal_bile_duct1.05422465
65MP0010307_abnormal_tumor_latency1.04217786
66MP0000015_abnormal_ear_pigmentation1.03719855
67MP0001533_abnormal_skeleton_physiology0.99680557
68MP0001929_abnormal_gametogenesis0.97459447
69MP0000350_abnormal_cell_proliferation0.95789155
70MP0002210_abnormal_sex_determination0.95507176
71MP0010234_abnormal_vibrissa_follicle0.91866984
72MP0000858_altered_metastatic_potential0.90197437
73MP0004185_abnormal_adipocyte_glucose0.87988364
74MP0003866_abnormal_defecation0.87897169
75MP0008469_abnormal_protein_level0.86589105
76MP0004957_abnormal_blastocyst_morpholog0.84265112
77MP0000313_abnormal_cell_death0.83773365
78MP0008004_abnormal_stomach_pH0.83461815
79MP0005076_abnormal_cell_differentiation0.81423293
80MP0001986_abnormal_taste_sensitivity0.79495535
81MP0009764_decreased_sensitivity_to0.77677339
82MP0001730_embryonic_growth_arrest0.77427793
83MP0003221_abnormal_cardiomyocyte_apopto0.75832045
84MP0009840_abnormal_foam_cell0.75000385
85MP0001145_abnormal_male_reproductive0.74634160
86MP0005621_abnormal_cell_physiology0.74434962
87MP0003699_abnormal_female_reproductive0.72745261
88MP0010352_gastrointestinal_tract_polyps0.72325287
89MP0003191_abnormal_cellular_cholesterol0.72114035
90MP0002998_abnormal_bone_remodeling0.72062413
91MP0003453_abnormal_keratinocyte_physiol0.71841167
92MP0000653_abnormal_sex_gland0.71207254
93MP0008995_early_reproductive_senescence0.71156782
94MP0009115_abnormal_fat_cell0.69800443
95MP0008260_abnormal_autophagy0.67500352
96MP0008007_abnormal_cellular_replicative0.67462444
97MP0008961_abnormal_basal_metabolism0.66269852
98MP0003943_abnormal_hepatobiliary_system0.65083263
99MP0001348_abnormal_lacrimal_gland0.63324267
100MP0001672_abnormal_embryogenesis/_devel0.60979396

Predicted human phenotypes

RankGene SetZ-score
1Panhypogammaglobulinemia (HP:0003139)4.61207518
2Agammaglobulinemia (HP:0004432)4.34027521
3B lymphocytopenia (HP:0010976)4.10092754
4Inflammation of the large intestine (HP:0002037)3.94548732
5Gastrointestinal inflammation (HP:0004386)3.91668962
6Gastrointestinal stroma tumor (HP:0100723)3.67850295
7Recurrent viral infections (HP:0004429)3.63124212
8Abnormality of B cell number (HP:0010975)3.61790860
9IgG deficiency (HP:0004315)3.50450419
10Abnormal delayed hypersensitivity skin test (HP:0002963)3.49327825
11T lymphocytopenia (HP:0005403)3.47712806
12Recurrent fungal infections (HP:0002841)3.47668912
13Meningitis (HP:0001287)3.44978170
14Abnormality of T cells (HP:0002843)3.44631901
15Papilloma (HP:0012740)3.34643484
16Verrucae (HP:0200043)3.34643484
17Lymphopenia (HP:0001888)3.29689754
18Chromsome breakage (HP:0040012)3.25723793
19Granulocytopenia (HP:0001913)3.21377091
20Severe combined immunodeficiency (HP:0004430)3.17897218
21Cellulitis (HP:0100658)3.15660433
22Abnormality of T cell physiology (HP:0011840)3.07159581
23Combined immunodeficiency (HP:0005387)3.05089958
24Abnormality of T cell number (HP:0011839)2.99306932
25Stomatitis (HP:0010280)2.99079182
26Increased IgM level (HP:0003496)2.96588474
27Aplasia/Hypoplasia of the thymus (HP:0010515)2.96447667
28Vasculitis (HP:0002633)2.95945324
29Abnormality of cells of the lymphoid lineage (HP:0012140)2.93356714
30Insidious onset (HP:0003587)2.89473517
31Termporal pattern (HP:0011008)2.89473517
32Viral hepatitis (HP:0006562)2.89010488
33Colitis (HP:0002583)2.86398682
34Chromosomal breakage induced by crosslinking agents (HP:0003221)2.85701311
35Eosinophilia (HP:0001880)2.83988986
36Recurrent cutaneous fungal infections (HP:0011370)2.82447191
37Chronic mucocutaneous candidiasis (HP:0002728)2.82447191
38Encephalitis (HP:0002383)2.73534868
39Recurrent abscess formation (HP:0002722)2.72737624
40Recurrent bacterial skin infections (HP:0005406)2.70798582
41Increased IgE level (HP:0003212)2.69560480
42Eczematoid dermatitis (HP:0000976)2.58571872
43Autoimmune hemolytic anemia (HP:0001890)2.57975337
44Abnormality of eosinophils (HP:0001879)2.55632604
45Prolonged bleeding time (HP:0003010)2.55133353
46Recurrent sinusitis (HP:0011108)2.54447567
47IgA deficiency (HP:0002720)2.46018783
48Lip pit (HP:0100267)2.44744369
49Lymphoma (HP:0002665)2.43777853
50Recurrent bronchitis (HP:0002837)2.43221973
51Fatigue (HP:0012378)2.41338715
52Hypoplasia of the thymus (HP:0000778)2.40592805
53Basal cell carcinoma (HP:0002671)2.39520210
54Mediastinal lymphadenopathy (HP:0100721)2.34405968
55Heterotopia (HP:0002282)2.33371557
56Abnormality of the thymus (HP:0000777)2.31835851
57Abnormality of the fingertips (HP:0001211)2.29603340
58Leukocytosis (HP:0001974)2.26254026
59Osteomyelitis (HP:0002754)2.22883838
60Chronic sinusitis (HP:0011109)2.19113174
61Facial hemangioma (HP:0000329)2.18764402
62IgM deficiency (HP:0002850)2.18662719
63Supernumerary spleens (HP:0009799)2.17971811
64Abnormality of the prostate (HP:0008775)2.17637464
65Prostate neoplasm (HP:0100787)2.17277597
66Abnormality of macrophages (HP:0004311)2.14638228
67Recurrent skin infections (HP:0001581)2.10556415
68Pustule (HP:0200039)2.09438822
69Deep palmar crease (HP:0006191)2.09221575
70Pulmonary infiltrates (HP:0002113)2.06905957
71Sepsis (HP:0100806)2.00667586
72Subacute progressive viral hepatitis (HP:0006572)1.99318258
73Abnormality of chromosome segregation (HP:0002916)1.96978425
74Obstructive lung disease (HP:0006536)1.95995948
75Chronic obstructive pulmonary disease (HP:0006510)1.95995948
76Thyroiditis (HP:0100646)1.95894963
77Optic neuritis (HP:0100653)1.94008807
78Retrobulbar optic neuritis (HP:0100654)1.94008807
79Multiple enchondromatosis (HP:0005701)1.91673662
80Gastrointestinal infarctions (HP:0005244)1.91121647
81Neutropenia (HP:0001875)1.90589353
82Microvesicular hepatic steatosis (HP:0001414)1.89645869
83Abnormality of the phalanges of the hallux (HP:0010057)1.88742059
84Progressive external ophthalmoplegia (HP:0000590)1.88576384
85Abnormal foot bone ossification (HP:0010675)1.87988978
86Acute lymphatic leukemia (HP:0006721)1.86408022
87Degeneration of the lateral corticospinal tracts (HP:0002314)1.84555585
88Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.84555585
893-Methylglutaconic aciduria (HP:0003535)1.83565067
90Gingival bleeding (HP:0000225)1.83271252
91Emphysema (HP:0002097)1.82933390
92Epistaxis (HP:0000421)1.81875130
93Chronic diarrhea (HP:0002028)1.81781773
94Restrictive lung disease (HP:0002091)1.80825568
95Carpal bone hypoplasia (HP:0001498)1.80516384
96Duplicated collecting system (HP:0000081)1.80392669
97Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.80325164
98Abnormality of chromosome stability (HP:0003220)1.79007754
99Myositis (HP:0100614)1.78563213
100Pulmonary fibrosis (HP:0002206)1.76702382

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.21001508
2PRPF4B3.58500241
3MAP4K13.50322986
4MAP3K132.67458906
5BRD42.59074682
6RIPK42.49369367
7MAP3K142.47955276
8IRAK42.31341001
9MARK32.09593080
10EIF2AK32.07034115
11PASK1.85785383
12TXK1.79618728
13ERN11.79017611
14TYK21.70700839
15MAP3K101.57867448
16IRAK11.55767352
17BTK1.55290922
18GRK61.49752538
19CSF1R1.47897148
20TRIB31.47545877
21MAP3K21.45283716
22BMPR21.41583296
23FES1.40183895
24SIK31.34499486
25MAPK111.30868892
26TNK21.27751776
27SYK1.26793120
28SCYL21.25293904
29MAP2K31.20465341
30STK241.19946057
31CDK71.17657850
32CDK91.17186368
33BLK1.16881669
34JAK31.16394397
35SMG11.16124667
36PIM11.12464830
37MAP2K21.12407439
38IRAK21.11822992
39TAOK31.10115248
40IKBKE1.09135554
41HCK1.06519820
42STK101.06473594
43ZAP701.04798922
44KSR21.04544031
45NLK1.02612389
46TAOK21.02265840
47IKBKB1.01894025
48JAK10.98888535
49MAP3K90.98800320
50CSK0.97982940
51ITK0.96520615
52LYN0.88585916
53TEC0.87026210
54TTK0.85967480
55TBK10.85523528
56CAMKK10.83852704
57PKN20.82723434
58ICK0.81661251
59SRPK10.81573439
60HIPK20.81262315
61NEK90.80435415
62NME20.78240129
63MARK20.77210785
64CDK40.76650348
65IRAK30.76467416
66FGFR30.75824527
67FGFR40.73237934
68MAP3K10.72905230
69MATK0.71499787
70FGR0.71428464
71LRRK20.71324538
72WNK10.69960359
73KIT0.68281285
74CLK10.67349343
75JAK20.66057192
76SIK10.65883525
77LCK0.63543582
78ARAF0.62909810
79NEK60.62303297
80PIK3CG0.61878216
81MAP3K50.61850520
82ALK0.58777819
83CDK30.57848293
84EEF2K0.57781961
85CHEK10.56154743
86RPS6KB20.54747524
87PRKCQ0.53888555
88MAP3K70.51200662
89RAF10.50245537
90MAPK70.49264168
91ACVR1B0.48482551
92CHUK0.48261087
93EPHB10.45159115
94PDK10.45072745
95MAPKAPK20.39482969
96MAPK30.39334060
97PRKD20.39213032
98CDK60.37878835
99ATR0.37850316
100MTOR0.37711922

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.91009213
2B cell receptor signaling pathway_Homo sapiens_hsa046623.31850061
3T cell receptor signaling pathway_Homo sapiens_hsa046602.20637666
4Osteoclast differentiation_Homo sapiens_hsa043802.16591008
5Acute myeloid leukemia_Homo sapiens_hsa052212.14875508
6Leishmaniasis_Homo sapiens_hsa051401.93790863
7NF-kappa B signaling pathway_Homo sapiens_hsa040641.90749749
8Non-homologous end-joining_Homo sapiens_hsa034501.89017278
9Herpes simplex infection_Homo sapiens_hsa051681.85966732
10Intestinal immune network for IgA production_Homo sapiens_hsa046721.73750746
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.69533137
12Hepatitis B_Homo sapiens_hsa051611.68769519
13Allograft rejection_Homo sapiens_hsa053301.66683980
14Measles_Homo sapiens_hsa051621.66048949
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.62468477
16Autoimmune thyroid disease_Homo sapiens_hsa053201.61562851
17Non-small cell lung cancer_Homo sapiens_hsa052231.61434133
18Hematopoietic cell lineage_Homo sapiens_hsa046401.60927737
19Cell cycle_Homo sapiens_hsa041101.59624619
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.57707807
21RNA transport_Homo sapiens_hsa030131.49187345
22Dorso-ventral axis formation_Homo sapiens_hsa043201.48214514
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.45168563
24mRNA surveillance pathway_Homo sapiens_hsa030151.44746250
25DNA replication_Homo sapiens_hsa030301.42452067
26Graft-versus-host disease_Homo sapiens_hsa053321.41443458
27Viral carcinogenesis_Homo sapiens_hsa052031.39102551
28Chronic myeloid leukemia_Homo sapiens_hsa052201.37208661
29Pancreatic cancer_Homo sapiens_hsa052121.35163658
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32981258
31Toxoplasmosis_Homo sapiens_hsa051451.32033928
32Influenza A_Homo sapiens_hsa051641.31156555
33Basal transcription factors_Homo sapiens_hsa030221.29632199
34Asthma_Homo sapiens_hsa053101.26858392
35Mismatch repair_Homo sapiens_hsa034301.22545358
36TNF signaling pathway_Homo sapiens_hsa046681.20170402
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.18918515
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.17814525
39Tuberculosis_Homo sapiens_hsa051521.15457605
40Epstein-Barr virus infection_Homo sapiens_hsa051691.13679725
41HTLV-I infection_Homo sapiens_hsa051661.09930960
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09754445
43RNA degradation_Homo sapiens_hsa030181.08088443
44NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08047440
45Apoptosis_Homo sapiens_hsa042101.04512040
46Antigen processing and presentation_Homo sapiens_hsa046121.03879277
47p53 signaling pathway_Homo sapiens_hsa041151.03740057
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.02806188
49Legionellosis_Homo sapiens_hsa051341.02258603
50Spliceosome_Homo sapiens_hsa030401.00905905
51Inositol phosphate metabolism_Homo sapiens_hsa005621.00439030
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.00277339
53mTOR signaling pathway_Homo sapiens_hsa041500.99880105
54Hepatitis C_Homo sapiens_hsa051600.99411800
55Renal cell carcinoma_Homo sapiens_hsa052110.98469115
56Homologous recombination_Homo sapiens_hsa034400.97229990
57Base excision repair_Homo sapiens_hsa034100.96368974
58Prolactin signaling pathway_Homo sapiens_hsa049170.95227342
59Nucleotide excision repair_Homo sapiens_hsa034200.91492073
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91407428
61FoxO signaling pathway_Homo sapiens_hsa040680.89628812
62Prostate cancer_Homo sapiens_hsa052150.89572830
63Viral myocarditis_Homo sapiens_hsa054160.88626715
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.88310246
65Chemokine signaling pathway_Homo sapiens_hsa040620.86793758
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84731447
67Small cell lung cancer_Homo sapiens_hsa052220.84112296
68Type I diabetes mellitus_Homo sapiens_hsa049400.83700858
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83385823
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.82778634
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80436978
72VEGF signaling pathway_Homo sapiens_hsa043700.79757367
73Staphylococcus aureus infection_Homo sapiens_hsa051500.79033198
74Choline metabolism in cancer_Homo sapiens_hsa052310.78567492
75Colorectal cancer_Homo sapiens_hsa052100.77812737
76Endometrial cancer_Homo sapiens_hsa052130.77807346
77Thyroid cancer_Homo sapiens_hsa052160.77449336
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71130679
79ErbB signaling pathway_Homo sapiens_hsa040120.70260684
80MicroRNAs in cancer_Homo sapiens_hsa052060.69934547
81Platelet activation_Homo sapiens_hsa046110.68540381
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.65192333
83Oocyte meiosis_Homo sapiens_hsa041140.64112273
84ABC transporters_Homo sapiens_hsa020100.63226672
85Malaria_Homo sapiens_hsa051440.60386583
86Fanconi anemia pathway_Homo sapiens_hsa034600.60356642
87MAPK signaling pathway_Homo sapiens_hsa040100.56618194
88Shigellosis_Homo sapiens_hsa051310.53331416
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.53145731
90Glioma_Homo sapiens_hsa052140.49564445
91Regulation of autophagy_Homo sapiens_hsa041400.48781515
92RNA polymerase_Homo sapiens_hsa030200.48128958
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47841550
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46614653
95Fatty acid biosynthesis_Homo sapiens_hsa000610.45362373
96Notch signaling pathway_Homo sapiens_hsa043300.42300100
97Insulin resistance_Homo sapiens_hsa049310.40558817
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40293503
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.40117662
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39476364

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »