BNIP3P17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromatin remodeling at centromere (GO:0031055)5.51457091
2CENP-A containing nucleosome assembly (GO:0034080)5.20315918
3DNA double-strand break processing (GO:0000729)5.07191462
4negative regulation of DNA-dependent DNA replication (GO:2000104)4.98418513
5histone exchange (GO:0043486)4.76473963
6DNA replication checkpoint (GO:0000076)4.76061244
7mitotic metaphase plate congression (GO:0007080)4.51917407
8protein localization to kinetochore (GO:0034501)4.40133979
9regulation of mitotic spindle checkpoint (GO:1903504)4.35033418
10regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.35033418
11DNA replication-independent nucleosome assembly (GO:0006336)4.30773613
12DNA replication-independent nucleosome organization (GO:0034724)4.30773613
13mitotic G2/M transition checkpoint (GO:0044818)4.16832513
14DNA replication-dependent nucleosome assembly (GO:0006335)4.14107882
15DNA replication-dependent nucleosome organization (GO:0034723)4.14107882
16metaphase plate congression (GO:0051310)4.11529065
17anterior/posterior axis specification, embryo (GO:0008595)4.07654731
18replication fork processing (GO:0031297)4.01564892
19spindle checkpoint (GO:0031577)3.94712390
20regulation of nuclear cell cycle DNA replication (GO:0033262)3.90403246
21mitotic sister chromatid segregation (GO:0000070)3.89897111
22proteasome assembly (GO:0043248)3.89006145
23DNA strand elongation involved in DNA replication (GO:0006271)3.87509211
24mitotic spindle checkpoint (GO:0071174)3.86364469
25negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.84769914
26negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.84769914
27negative regulation of mitotic sister chromatid segregation (GO:0033048)3.84769914
28negative regulation of mitotic sister chromatid separation (GO:2000816)3.84769914
29negative regulation of sister chromatid segregation (GO:0033046)3.84769914
30sister chromatid segregation (GO:0000819)3.78369251
31negative regulation of chromosome segregation (GO:0051985)3.76207280
32telomere maintenance via semi-conservative replication (GO:0032201)3.73172246
33maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.71769802
34establishment of integrated proviral latency (GO:0075713)3.69321151
35negative regulation of DNA recombination (GO:0045910)3.67625936
36kinetochore organization (GO:0051383)3.65072828
37DNA catabolic process, exonucleolytic (GO:0000738)3.64717378
38DNA ligation (GO:0006266)3.64251092
39mitotic recombination (GO:0006312)3.64056654
40DNA strand elongation (GO:0022616)3.63299320
41somatic diversification of immune receptors via somatic mutation (GO:0002566)3.61817490
42somatic hypermutation of immunoglobulin genes (GO:0016446)3.61817490
43mitotic G2 DNA damage checkpoint (GO:0007095)3.57684206
44regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.57604729
45IMP biosynthetic process (GO:0006188)3.54770255
46female gonad development (GO:0008585)3.53901969
47regulation of centriole replication (GO:0046599)3.52389357
48mitotic sister chromatid cohesion (GO:0007064)3.49527542
49regulation of helicase activity (GO:0051095)3.48778307
50mitotic spindle assembly checkpoint (GO:0007094)3.48728924
51cullin deneddylation (GO:0010388)3.48609781
52otic vesicle formation (GO:0030916)3.45155555
53regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.44402664
54regulation of mitotic metaphase/anaphase transition (GO:0030071)3.44402664
55spindle assembly checkpoint (GO:0071173)3.42477782
56response to X-ray (GO:0010165)3.38356002
57telomere maintenance via telomerase (GO:0007004)3.37066474
58purine nucleobase biosynthetic process (GO:0009113)3.36081631
59kinetochore assembly (GO:0051382)3.31871834
60double-strand break repair via nonhomologous end joining (GO:0006303)3.29898595
61non-recombinational repair (GO:0000726)3.29898595
62regulation of sister chromatid segregation (GO:0033045)3.29649163
63regulation of mitotic sister chromatid separation (GO:0010965)3.29649163
64regulation of mitotic sister chromatid segregation (GO:0033047)3.29649163
65ribosome assembly (GO:0042255)3.29102197
66establishment of chromosome localization (GO:0051303)3.28684004
67telomere maintenance via recombination (GO:0000722)3.28583977
68regulation of chromosome segregation (GO:0051983)3.25587535
69DNA unwinding involved in DNA replication (GO:0006268)3.23060720
70somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.22902166
71isotype switching (GO:0045190)3.22902166
72somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.22902166
73positive regulation of cardiac muscle cell proliferation (GO:0060045)3.20970988
74telomere maintenance via telomere lengthening (GO:0010833)3.18476051
75nodal signaling pathway (GO:0038092)3.17930400
76intra-S DNA damage checkpoint (GO:0031573)3.14582118
77negative regulation of mitosis (GO:0045839)3.13789730
78synapsis (GO:0007129)3.13090915
79heterochromatin organization (GO:0070828)3.10913059
80protein deneddylation (GO:0000338)3.10682222
81mitotic nuclear envelope disassembly (GO:0007077)3.07004473
82IMP metabolic process (GO:0046040)3.06930955
83protein localization to chromosome, centromeric region (GO:0071459)3.02924157
84L-serine metabolic process (GO:0006563)3.00275815
85RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.99532877
86regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.99400806
87centriole replication (GO:0007099)2.98275773
88nucleobase biosynthetic process (GO:0046112)2.98016327
89DNA strand renaturation (GO:0000733)2.97948138
90negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.96355777
91regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.96345861
92RNA-dependent DNA replication (GO:0006278)2.95738704
93double-strand break repair via homologous recombination (GO:0000724)2.94859907
94DNA damage response, detection of DNA damage (GO:0042769)2.94522220
95recombinational repair (GO:0000725)2.94513637
96DNA replication initiation (GO:0006270)2.93585123
97ATP-dependent chromatin remodeling (GO:0043044)2.92517593
98ventricular cardiac muscle cell development (GO:0055015)2.88669114
99histone mRNA metabolic process (GO:0008334)2.88445301
100negative regulation of nuclear division (GO:0051784)2.88399520

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.90723938
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.18533247
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.13256959
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.26979509
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.16490011
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.02275515
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.97119351
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.96047063
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.77444084
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.76690407
11AR_21909140_ChIP-Seq_LNCAP_Human2.70029930
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.40511527
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.35310014
14KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.25482532
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.20891252
16ELK1_19687146_ChIP-ChIP_HELA_Human2.20465834
17POU5F1_16153702_ChIP-ChIP_HESCs_Human2.07277373
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.99830417
19MYC_18555785_ChIP-Seq_MESCs_Mouse1.94568513
20ZNF274_21170338_ChIP-Seq_K562_Hela1.91712518
21EWS_26573619_Chip-Seq_HEK293_Human1.81542553
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78997223
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.78404919
24NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.77241615
25MYC_19030024_ChIP-ChIP_MESCs_Mouse1.76444356
26E2F1_21310950_ChIP-Seq_MCF-7_Human1.72100552
27NANOG_16153702_ChIP-ChIP_HESCs_Human1.70225972
28VDR_23849224_ChIP-Seq_CD4+_Human1.69841973
29FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69540251
30FUS_26573619_Chip-Seq_HEK293_Human1.68943117
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.68619857
32FOXP3_21729870_ChIP-Seq_TREG_Human1.63179323
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.60364222
34P300_19829295_ChIP-Seq_ESCs_Human1.60289252
35JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.58027256
36KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.57450870
37KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.57450870
38KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.57450870
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.54458825
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54417519
41VDR_22108803_ChIP-Seq_LS180_Human1.54260915
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53317406
43MYC_19079543_ChIP-ChIP_MESCs_Mouse1.50792828
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49061364
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.46772005
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.45402836
47SOX2_16153702_ChIP-ChIP_HESCs_Human1.41568887
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39385860
49NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.37909306
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33848985
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30390010
52TAF15_26573619_Chip-Seq_HEK293_Human1.29687777
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.28365658
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27888635
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27879005
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.26529714
57MYC_18940864_ChIP-ChIP_HL60_Human1.25923489
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.23892659
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.23812068
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22327784
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21414682
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21209742
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20464140
64HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.15779480
65NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14918815
66ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14897556
67GABP_19822575_ChIP-Seq_HepG2_Human1.14683613
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11182417
69PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08537878
70DCP1A_22483619_ChIP-Seq_HELA_Human1.08401340
71TTF2_22483619_ChIP-Seq_HELA_Human1.06059159
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04344593
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02854576
74SRF_21415370_ChIP-Seq_HL-1_Mouse1.02255322
75MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.01644449
76TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01558847
77GBX2_23144817_ChIP-Seq_PC3_Human0.99344145
78GATA1_26923725_Chip-Seq_HPCs_Mouse0.99242169
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98040404
80TP63_19390658_ChIP-ChIP_HaCaT_Human0.96491234
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95740859
82THAP11_20581084_ChIP-Seq_MESCs_Mouse0.95693361
83HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94776461
84CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94186939
85NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.94010182
86IGF1R_20145208_ChIP-Seq_DFB_Human0.92383615
87IRF1_19129219_ChIP-ChIP_H3396_Human0.91068069
88HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.90942178
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89702158
90SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89605104
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88860645
92CRX_20693478_ChIP-Seq_RETINA_Mouse0.88648717
93P300_18555785_Chip-Seq_ESCs_Mouse0.87914301
94TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.86972985
95SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.86542330
96NANOG_18555785_ChIP-Seq_MESCs_Mouse0.86463619
97EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.86319295
98SMAD3_21741376_ChIP-Seq_EPCs_Human0.86185047
99ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.85542984
100CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.85069770

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.11632666
2MP0003941_abnormal_skin_development3.77657367
3MP0003693_abnormal_embryo_hatching3.69084656
4MP0002254_reproductive_system_inflammat3.67843903
5MP0008058_abnormal_DNA_repair3.66714113
6MP0003890_abnormal_embryonic-extraembry3.55369879
7MP0008877_abnormal_DNA_methylation3.34514384
8MP0008057_abnormal_DNA_replication3.29769981
9MP0004957_abnormal_blastocyst_morpholog3.28872005
10MP0003111_abnormal_nucleus_morphology3.07673873
11MP0006292_abnormal_olfactory_placode2.87285621
12MP0008932_abnormal_embryonic_tissue2.53345554
13MP0003077_abnormal_cell_cycle2.43610405
14MP0008007_abnormal_cellular_replicative2.36084925
15MP0003119_abnormal_digestive_system2.07560656
16MP0003136_yellow_coat_color2.05801357
17MP0001293_anophthalmia2.01265491
18MP0003567_abnormal_fetal_cardiomyocyte1.99067095
19MP0003718_maternal_effect1.97806014
20MP0009672_abnormal_birth_weight1.84371421
21MP0003786_premature_aging1.78849709
22MP0001188_hyperpigmentation1.78054585
23MP0002102_abnormal_ear_morphology1.69881340
24MP0010030_abnormal_orbit_morphology1.67443907
25MP0003121_genomic_imprinting1.63929904
26MP0009697_abnormal_copulation1.57822000
27MP0003123_paternal_imprinting1.50532543
28MP0002938_white_spotting1.46400020
29MP0003195_calcinosis1.45167390
30MP0001730_embryonic_growth_arrest1.43819983
31MP0004264_abnormal_extraembryonic_tissu1.40322866
32MP0003937_abnormal_limbs/digits/tail_de1.39519711
33MP0002751_abnormal_autonomic_nervous1.36833936
34MP0001672_abnormal_embryogenesis/_devel1.35918255
35MP0005380_embryogenesis_phenotype1.35918255
36MP0002736_abnormal_nociception_after1.35473837
37MP0001177_atelectasis1.33790687
38MP0010307_abnormal_tumor_latency1.28788531
39MP0002084_abnormal_developmental_patter1.28684866
40MP0001697_abnormal_embryo_size1.27067075
41MP0004133_heterotaxia1.24898182
42MP0003787_abnormal_imprinting1.22097732
43MP0000350_abnormal_cell_proliferation1.21736658
44MP0002085_abnormal_embryonic_tissue1.21128439
45MP0001286_abnormal_eye_development1.17950513
46MP0002233_abnormal_nose_morphology1.17822137
47MP0009703_decreased_birth_body1.16707926
48MP0006035_abnormal_mitochondrial_morpho1.15900664
49MP0010352_gastrointestinal_tract_polyps1.13223878
50MP0003984_embryonic_growth_retardation1.12261823
51MP0008789_abnormal_olfactory_epithelium1.12184681
52MP0000516_abnormal_urinary_system1.11858816
53MP0005367_renal/urinary_system_phenotyp1.11858816
54MP0001529_abnormal_vocalization1.11673821
55MP0002088_abnormal_embryonic_growth/wei1.11514166
56MP0001485_abnormal_pinna_reflex1.05781156
57MP0000647_abnormal_sebaceous_gland1.05462563
58MP0002277_abnormal_respiratory_mucosa1.04030948
59MP0003137_abnormal_impulse_conducting1.03110392
60MP0006072_abnormal_retinal_apoptosis1.02806206
61MP0000372_irregular_coat_pigmentation1.02784329
62MP0002080_prenatal_lethality0.99060984
63MP0002210_abnormal_sex_determination0.96518967
64MP0000579_abnormal_nail_morphology0.96341622
65MP0008004_abnormal_stomach_pH0.96327662
66MP0001929_abnormal_gametogenesis0.95793670
67MP0002697_abnormal_eye_size0.95455607
68MP0002234_abnormal_pharynx_morphology0.91100978
69MP0004215_abnormal_myocardial_fiber0.89760840
70MP0003122_maternal_imprinting0.89554053
71MP0004197_abnormal_fetal_growth/weight/0.89406865
72MP0003806_abnormal_nucleotide_metabolis0.87931397
73MP0005084_abnormal_gallbladder_morpholo0.87666889
74MP0003880_abnormal_central_pattern0.87665524
75MP0005394_taste/olfaction_phenotype0.85091731
76MP0005499_abnormal_olfactory_system0.85091731
77MP0003186_abnormal_redox_activity0.83955652
78MP0005551_abnormal_eye_electrophysiolog0.83305408
79MP0001299_abnormal_eye_distance/0.83105630
80MP0000653_abnormal_sex_gland0.81771987
81MP0001145_abnormal_male_reproductive0.81657667
82MP0002086_abnormal_extraembryonic_tissu0.80990758
83MP0002111_abnormal_tail_morphology0.80606297
84MP0000313_abnormal_cell_death0.80549170
85MP0000427_abnormal_hair_cycle0.79381069
86MP0006054_spinal_hemorrhage0.79335244
87MP0003943_abnormal_hepatobiliary_system0.78082651
88MP0002090_abnormal_vision0.77155373
89MP0005253_abnormal_eye_physiology0.75544690
90MP0005075_abnormal_melanosome_morpholog0.73515422
91MP0000428_abnormal_craniofacial_morphol0.72360991
92MP0003283_abnormal_digestive_organ0.70710766
93MP0001119_abnormal_female_reproductive0.70530216
94MP0003011_delayed_dark_adaptation0.65905896
95MP0004147_increased_porphyrin_level0.65226798
96MP0005395_other_phenotype0.64892009
97MP0000049_abnormal_middle_ear0.64885719
98MP0003936_abnormal_reproductive_system0.64616288
99MP0005391_vision/eye_phenotype0.64474752
100MP0003861_abnormal_nervous_system0.64430653

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)5.17609979
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.99941189
3Chromsome breakage (HP:0040012)3.92736057
4Abnormality of chromosome stability (HP:0003220)3.87547704
5Meckel diverticulum (HP:0002245)3.78375434
6Abnormality of the ileum (HP:0001549)3.64328603
7Progressive inability to walk (HP:0002505)3.64113074
8Aplasia/Hypoplasia of the uvula (HP:0010293)3.52498408
9Colon cancer (HP:0003003)3.43937821
10Birth length less than 3rd percentile (HP:0003561)3.43405140
11Abnormality of the preputium (HP:0100587)3.27876446
12Intestinal atresia (HP:0011100)3.27731895
13Abnormality of the duodenum (HP:0002246)3.19093302
14Pancreatic islet-cell hyperplasia (HP:0004510)3.13145345
15Duodenal stenosis (HP:0100867)3.10718799
16Small intestinal stenosis (HP:0012848)3.10718799
17Ependymoma (HP:0002888)3.10183047
18Volvulus (HP:0002580)3.09318391
19Septo-optic dysplasia (HP:0100842)2.90487511
20Abnormality of the parathyroid morphology (HP:0011766)2.88216679
21Abnormal lung lobation (HP:0002101)2.85948684
22Aqueductal stenosis (HP:0002410)2.78479518
23Embryonal renal neoplasm (HP:0011794)2.70815428
24Nephroblastoma (Wilms tumor) (HP:0002667)2.69179369
25Absent radius (HP:0003974)2.66266214
26Methylmalonic acidemia (HP:0002912)2.50786516
27Absent forearm bone (HP:0003953)2.50672289
28Aplasia involving forearm bones (HP:0009822)2.50672289
29Multiple enchondromatosis (HP:0005701)2.50072771
30Abnormality of the fetal cardiovascular system (HP:0010948)2.44612272
31Abnormal umbilical cord blood vessels (HP:0011403)2.44612272
32Single umbilical artery (HP:0001195)2.44612272
33Abnormality of serum amino acid levels (HP:0003112)2.43114482
34Sloping forehead (HP:0000340)2.41750733
35Abnormality of alanine metabolism (HP:0010916)2.39048105
36Hyperalaninemia (HP:0003348)2.39048105
37Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.39048105
38Neoplasm of the adrenal gland (HP:0100631)2.37487417
39Triphalangeal thumb (HP:0001199)2.35788287
40Double outlet right ventricle (HP:0001719)2.35326263
41Congenital malformation of the right heart (HP:0011723)2.35326263
42Rhabdomyosarcoma (HP:0002859)2.33694186
43Abnormality of aspartate family amino acid metabolism (HP:0010899)2.32896097
44Abnormality of methionine metabolism (HP:0010901)2.32497832
45Neoplasm of the oral cavity (HP:0100649)2.31864910
46Oligodactyly (hands) (HP:0001180)2.31674440
47Clubbing of toes (HP:0100760)2.30920116
48Glioma (HP:0009733)2.28790106
49Agnosia (HP:0010524)2.22063913
50Abnormal hair whorl (HP:0010721)2.21501031
51Esophageal atresia (HP:0002032)2.15846548
52Absent septum pellucidum (HP:0001331)2.14881083
53Medulloblastoma (HP:0002885)2.12692969
54Bifid tongue (HP:0010297)2.11474946
55Carpal bone hypoplasia (HP:0001498)2.07985383
56Abnormality of the carotid arteries (HP:0005344)2.07602060
57Horseshoe kidney (HP:0000085)2.07481997
58Inability to walk (HP:0002540)2.07044116
59Hypoglycemic seizures (HP:0002173)2.06298797
60Hyperglycinuria (HP:0003108)2.05569796
61Gastrointestinal atresia (HP:0002589)2.02676877
62Stenosis of the external auditory canal (HP:0000402)2.00138472
63Ectopic kidney (HP:0000086)2.00009686
64Hypoplastic female external genitalia (HP:0012815)1.99359311
65Abnormality of homocysteine metabolism (HP:0010919)1.99220757
66Homocystinuria (HP:0002156)1.99220757
67Pancreatic cysts (HP:0001737)1.98126670
68Astrocytoma (HP:0009592)1.96601439
69Abnormality of the astrocytes (HP:0100707)1.96601439
70Labial hypoplasia (HP:0000066)1.94763906
71Hyperglycinemia (HP:0002154)1.94604339
72Abnormality of serine family amino acid metabolism (HP:0010894)1.94206360
73Abnormality of glycine metabolism (HP:0010895)1.94206360
74Abnormality of the septum pellucidum (HP:0007375)1.93545716
75Abnormal pancreas size (HP:0012094)1.93281280
76Methylmalonic aciduria (HP:0012120)1.92899043
77Abnormality of the clitoris (HP:0000056)1.92151015
78Symptomatic seizures (HP:0011145)1.91389995
79Small hand (HP:0200055)1.91031669
80Abnormality of endocrine pancreas physiology (HP:0012093)1.89650364
81Abnormality of the pancreatic islet cells (HP:0006476)1.89650364
82Abnormality of the umbilical cord (HP:0010881)1.88125760
83Ovarian neoplasm (HP:0100615)1.87466408
84Anophthalmia (HP:0000528)1.84021201
85Choanal atresia (HP:0000453)1.83628794
86Hypoplasia of the pons (HP:0012110)1.81042021
87Abnormality of the labia (HP:0000058)1.77900420
88Myelodysplasia (HP:0002863)1.77298981
89Abnormality of the pons (HP:0007361)1.76469568
90Gonadotropin excess (HP:0000837)1.76350098
91Abolished electroretinogram (ERG) (HP:0000550)1.75506483
92Anal stenosis (HP:0002025)1.72281408
93Growth hormone deficiency (HP:0000824)1.71149429
94Breast carcinoma (HP:0003002)1.70971849
95Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70921531
96Preaxial hand polydactyly (HP:0001177)1.70458376
97Biliary tract neoplasm (HP:0100574)1.68923253
98True hermaphroditism (HP:0010459)1.68904530
99Vaginal atresia (HP:0000148)1.68527875
100Astigmatism (HP:0000483)1.68187644

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.67106059
2BUB13.65296425
3ERBB43.31018512
4ACVR1B3.28071030
5TSSK63.27998109
6PBK3.24824034
7PDK23.19149309
8MKNK23.16262909
9TNIK3.00764425
10TTK2.99132365
11WNK32.77181789
12BMPR1B2.68121270
13PLK32.52317071
14NEK12.44715548
15MKNK12.41098947
16CDC72.32692702
17PLK42.29775731
18WEE12.27914954
19ZAK2.26245358
20MST42.17897950
21EIF2AK32.16912417
22NUAK11.78087596
23BRSK21.77118515
24SRPK11.74744464
25TGFBR11.55233382
26PLK11.53951061
27VRK11.49505830
28VRK21.35510498
29SIK31.33706960
30STK161.33591958
31FRK1.32589249
32PNCK1.31395642
33EIF2AK21.23630635
34MAP4K21.20326868
35TAF11.11438183
36ERBB31.05846422
37BCR1.03586144
38ATR1.02545047
39GRK11.01671274
40NEK21.00483320
41NLK0.96286279
42STK30.89812623
43EIF2AK10.88242269
44OXSR10.85365219
45CHEK20.81733310
46BRSK10.80813094
47PASK0.78046433
48PLK20.71575967
49ATM0.70775473
50STK40.68292863
51MELK0.68287465
52CHEK10.67972645
53AURKB0.66626704
54MAPK130.64768218
55CASK0.64679729
56STK390.59590849
57FGFR10.56948692
58STK38L0.56692804
59ALK0.55514454
60PRKCG0.51677001
61FGFR20.47965893
62CSNK1G10.47164621
63DYRK20.43683681
64DAPK10.43124313
65CSNK2A10.40022247
66MINK10.39431583
67RPS6KA40.39155233
68INSRR0.38899014
69CDK70.38708975
70PRKDC0.37285106
71FLT30.36501839
72NME10.35951887
73DYRK30.35386525
74CDK190.33780674
75PAK30.33342470
76CDK10.33175938
77MAP3K100.31996773
78MAP3K80.31745030
79PRKCE0.29923959
80BRAF0.29854174
81PINK10.29752232
82CSNK1E0.29565800
83CSNK2A20.29011194
84TIE10.27767756
85CSNK1G20.26772566
86PKN10.24698364
87CDK20.24357988
88CDK30.24245180
89STK100.22567982
90CLK10.21847007
91CSNK1D0.21515172
92CSNK1G30.18642184
93YES10.18015366
94FGR0.17117987
95CDK40.16747042
96PRKACB0.16626534
97BRD40.16455431
98PRKCI0.16272314
99CSNK1A10.15812229
100LATS10.14755675

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.89688912
2Non-homologous end-joining_Homo sapiens_hsa034503.67449848
3Homologous recombination_Homo sapiens_hsa034403.41464829
4DNA replication_Homo sapiens_hsa030303.40174264
5Proteasome_Homo sapiens_hsa030503.27939830
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.82514852
7Fanconi anemia pathway_Homo sapiens_hsa034602.68938350
8Propanoate metabolism_Homo sapiens_hsa006402.30014737
9RNA transport_Homo sapiens_hsa030132.20455224
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.19067357
11Base excision repair_Homo sapiens_hsa034102.15308293
12Cell cycle_Homo sapiens_hsa041102.13933800
13Cysteine and methionine metabolism_Homo sapiens_hsa002702.09308415
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.07545825
15RNA polymerase_Homo sapiens_hsa030202.00492309
16One carbon pool by folate_Homo sapiens_hsa006701.97252320
17Protein export_Homo sapiens_hsa030601.96289649
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.95875112
19RNA degradation_Homo sapiens_hsa030181.89310245
20Pyruvate metabolism_Homo sapiens_hsa006201.88745508
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.86899030
22Basal transcription factors_Homo sapiens_hsa030221.86286324
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.85781355
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82352049
25Steroid biosynthesis_Homo sapiens_hsa001001.81285004
26Nucleotide excision repair_Homo sapiens_hsa034201.71745154
27Vitamin B6 metabolism_Homo sapiens_hsa007501.69889016
28Spliceosome_Homo sapiens_hsa030401.65376175
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51718263
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.44079953
31Selenocompound metabolism_Homo sapiens_hsa004501.43166394
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.38160474
33Fatty acid elongation_Homo sapiens_hsa000621.31856285
34mRNA surveillance pathway_Homo sapiens_hsa030151.21302855
35Oocyte meiosis_Homo sapiens_hsa041141.19352682
36Glutathione metabolism_Homo sapiens_hsa004801.19037358
37Pyrimidine metabolism_Homo sapiens_hsa002401.11246935
38Carbon metabolism_Homo sapiens_hsa012001.02748734
39p53 signaling pathway_Homo sapiens_hsa041151.01994354
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.01928532
41Purine metabolism_Homo sapiens_hsa002301.00018189
42beta-Alanine metabolism_Homo sapiens_hsa004100.92297202
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88302719
44Biosynthesis of amino acids_Homo sapiens_hsa012300.86709075
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86177507
46Fatty acid degradation_Homo sapiens_hsa000710.85919803
47Phototransduction_Homo sapiens_hsa047440.85573990
48Vitamin digestion and absorption_Homo sapiens_hsa049770.84981678
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84926405
50Butanoate metabolism_Homo sapiens_hsa006500.82263573
51Fat digestion and absorption_Homo sapiens_hsa049750.80960003
52Peroxisome_Homo sapiens_hsa041460.76517788
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76245666
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75870174
55Fatty acid metabolism_Homo sapiens_hsa012120.75673725
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68825291
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68668978
58Tryptophan metabolism_Homo sapiens_hsa003800.66137196
59TGF-beta signaling pathway_Homo sapiens_hsa043500.64951831
60Oxidative phosphorylation_Homo sapiens_hsa001900.63988455
61Retinol metabolism_Homo sapiens_hsa008300.63348576
62Parkinsons disease_Homo sapiens_hsa050120.61988558
63Huntingtons disease_Homo sapiens_hsa050160.58933698
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58523213
65Basal cell carcinoma_Homo sapiens_hsa052170.57796253
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57245227
67Metabolic pathways_Homo sapiens_hsa011000.55883670
68Hippo signaling pathway_Homo sapiens_hsa043900.55455384
69Arginine and proline metabolism_Homo sapiens_hsa003300.53301047
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52550818
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52370856
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51525527
73Ether lipid metabolism_Homo sapiens_hsa005650.51498070
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49873019
75Wnt signaling pathway_Homo sapiens_hsa043100.47965824
76Lysine degradation_Homo sapiens_hsa003100.47412735
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45940939
78Caffeine metabolism_Homo sapiens_hsa002320.45747190
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.44225548
80Linoleic acid metabolism_Homo sapiens_hsa005910.44159118
81Tight junction_Homo sapiens_hsa045300.43884063
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40353817
83Olfactory transduction_Homo sapiens_hsa047400.39159838
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35298516
85Chemical carcinogenesis_Homo sapiens_hsa052040.34578004
86Folate biosynthesis_Homo sapiens_hsa007900.33364264
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33314831
88Nitrogen metabolism_Homo sapiens_hsa009100.32568839
89Adherens junction_Homo sapiens_hsa045200.27077598
90Hedgehog signaling pathway_Homo sapiens_hsa043400.25973111
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25520527
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.25278871
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.24604451
94Nicotine addiction_Homo sapiens_hsa050330.23431740
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.22055561
96N-Glycan biosynthesis_Homo sapiens_hsa005100.19409861
97Legionellosis_Homo sapiens_hsa051340.17098769
98Histidine metabolism_Homo sapiens_hsa003400.16547269
99Alzheimers disease_Homo sapiens_hsa050100.13557977
100Regulation of autophagy_Homo sapiens_hsa041400.13514590

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