ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	aldehyde catabolic process (GO:0046185)	5.83150930
2	ovulation from ovarian follicle (GO:0001542)	5.04795016
3	L-alpha-amino acid transmembrane transport (GO:1902475)	4.93519881
4	platelet dense granule organization (GO:0060155)	4.64520425
5	regulation of DNA endoreduplication (GO:0032875)	4.52264080
6	proteasome assembly (GO:0043248)	4.51001188
7	negative regulation of DNA-dependent DNA replication (GO:2000104)	4.49515505
8	glucuronate metabolic process (GO:0019585)	4.37719479
9	uronic acid metabolic process (GO:0006063)	4.37719479
10	cellular ketone body metabolic process (GO:0046950)	4.36588841
11	adult feeding behavior (GO:0008343)	4.35245154
12	response to pheromone (GO:0019236)	4.34831028
13	DNA double-strand break processing (GO:0000729)	4.33788068
14	righting reflex (GO:0060013)	4.30353788
15	replication fork processing (GO:0031297)	4.27152924
16	flavonoid metabolic process (GO:0009812)	4.22414321
17	cellular glucuronidation (GO:0052695)	4.17972497
18	nonmotile primary cilium assembly (GO:0035058)	3.98048303
19	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.96342086
20	glyoxylate metabolic process (GO:0046487)	3.86865871
21	female gonad development (GO:0008585)	3.85967034
22	intra-S DNA damage checkpoint (GO:0031573)	3.85394720
23	ketone body metabolic process (GO:1902224)	3.84685527
24	lactate metabolic process (GO:0006089)	3.78004116
25	respiratory chain complex IV assembly (GO:0008535)	3.74880890
26	auditory receptor cell stereocilium organization (GO:0060088)	3.68516339
27	heme transport (GO:0015886)	3.59637441
28	water-soluble vitamin biosynthetic process (GO:0042364)	3.59077145
29	startle response (GO:0001964)	3.53656999
30	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	3.44338145
31	L-serine metabolic process (GO:0006563)	3.29540862
32	photoreceptor cell maintenance (GO:0045494)	3.25389701
33	serine family amino acid biosynthetic process (GO:0009070)	3.21122850
34	telomere maintenance via telomerase (GO:0007004)	3.20870058
35	zinc ion transport (GO:0006829)	3.10330633
36	single strand break repair (GO:0000012)	3.10176739
37	synapsis (GO:0007129)	3.08808366
38	mitochondrial DNA replication (GO:0006264)	3.08241765
39	cullin deneddylation (GO:0010388)	3.04771615
40	attachment of spindle microtubules to kinetochore (GO:0008608)	3.01552498
41	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.00376127
42	protein neddylation (GO:0045116)	3.00180133
43	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	2.98483143
44	chromatin remodeling at centromere (GO:0031055)	2.96358369
45	acrosome assembly (GO:0001675)	2.93739566
46	DNA strand renaturation (GO:0000733)	2.92544794
47	DNA replication checkpoint (GO:0000076)	2.88429970
48	positive regulation of response to extracellular stimulus (GO:0032106)	2.86064937
49	positive regulation of response to nutrient levels (GO:0032109)	2.86064937
50	regulation of telomere maintenance via telomerase (GO:0032210)	2.85853561
51	C21-steroid hormone metabolic process (GO:0008207)	2.84385276
52	cytochrome complex assembly (GO:0017004)	2.83141165
53	CENP-A containing nucleosome assembly (GO:0034080)	2.82752789
54	presynaptic membrane assembly (GO:0097105)	2.82282698
55	reflex (GO:0060004)	2.78730027
56	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)	2.78441159
57	protein complex biogenesis (GO:0070271)	2.77551091
58	protein deneddylation (GO:0000338)	2.76197518
59	spindle checkpoint (GO:0031577)	2.76086080
60	bile acid biosynthetic process (GO:0006699)	2.75078018
61	regulation of male gonad development (GO:2000018)	2.74349081
62	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.73679622
63	NADH dehydrogenase complex assembly (GO:0010257)	2.73679622
64	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.73679622
65	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.73243161
66	RNA-dependent DNA replication (GO:0006278)	2.70918833
67	retinoic acid metabolic process (GO:0042573)	2.70738564
68	mitotic cell cycle arrest (GO:0071850)	2.67974641
69	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.67803416
70	recombinational repair (GO:0000725)	2.66307998
71	branched-chain amino acid catabolic process (GO:0009083)	2.66212444
72	dopamine transport (GO:0015872)	2.65333723
73	mitotic spindle checkpoint (GO:0071174)	2.64821725
74	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.63142351
75	double-strand break repair via homologous recombination (GO:0000724)	2.62048683
76	COPII vesicle coating (GO:0048208)	2.59113511
77	mannosylation (GO:0097502)	2.56059664
78	somite rostral/caudal axis specification (GO:0032525)	2.55061243
79	intracellular protein transmembrane import (GO:0044743)	2.54858158
80	negative regulation of signal transduction by p53 class mediator (GO:1901797)	2.54687254
81	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.53727190
82	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.53727190
83	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.53712224
84	DNA catabolic process, exonucleolytic (GO:0000738)	2.53417314
85	inner ear receptor stereocilium organization (GO:0060122)	2.52568042
86	regulation of mitotic spindle checkpoint (GO:1903504)	2.50029456
87	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.50029456
88	lipid particle organization (GO:0034389)	2.49922661
89	ribosome assembly (GO:0042255)	2.46223686
90	mitochondrial respiratory chain complex assembly (GO:0033108)	2.45740585
91	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.43342466
92	regulation of cofactor metabolic process (GO:0051193)	2.41336848
93	regulation of coenzyme metabolic process (GO:0051196)	2.41336848
94	7-methylguanosine mRNA capping (GO:0006370)	2.40728971
95	histone exchange (GO:0043486)	2.40573862
96	iron coordination entity transport (GO:1901678)	2.40237755
97	histone H2A acetylation (GO:0043968)	2.37947050
98	preassembly of GPI anchor in ER membrane (GO:0016254)	2.35989440
99	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	2.34662099
100	7-methylguanosine RNA capping (GO:0009452)	2.34414339

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.43510550
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.89240910
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.58458251
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.92866860
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.89562411
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.67358671
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.62645501
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.47854111
9	EWS_26573619_Chip-Seq_HEK293_Human	2.41898466
10	ELK1_19687146_ChIP-ChIP_HELA_Human	2.38280704
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.27893192
12	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.27802529
13	P300_19829295_ChIP-Seq_ESCs_Human	2.23468425
14	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.22143657
15	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.09646047
16	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.08897792
17	TAF15_26573619_Chip-Seq_HEK293_Human	2.07812436
18	IGF1R_20145208_ChIP-Seq_DFB_Human	2.03864505
19	FUS_26573619_Chip-Seq_HEK293_Human	2.02753060
20	E2F7_22180533_ChIP-Seq_HELA_Human	1.99591897
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.97764543
22	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.87814147
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.84761208
24	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.77754254
25	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.74156294
26	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.71969043
27	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.71960364
28	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.67052378
29	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.64794658
30	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.60416218
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.60405889
32	VDR_23849224_ChIP-Seq_CD4+_Human	1.59377177
33	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.50767394
34	AR_25329375_ChIP-Seq_VCAP_Human	1.50660381
35	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.49250431
36	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.48066341
37	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.46473755
38	SOX2_19829295_ChIP-Seq_ESCs_Human	1.43588662
39	NANOG_19829295_ChIP-Seq_ESCs_Human	1.43588662
40	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.42762405
41	IRF1_19129219_ChIP-ChIP_H3396_Human	1.41782052
42	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.41505633
43	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.41137313
44	TCF4_22108803_ChIP-Seq_LS180_Human	1.39748623
45	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.39702264
46	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.38450835
47	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.36181428
48	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.36181428
49	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.33516644
50	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.30856841
51	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.30213466
52	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.28930549
53	STAT3_23295773_ChIP-Seq_U87_Human	1.28645400
54	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.28062316
55	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.27184774
56	CBP_20019798_ChIP-Seq_JUKART_Human	1.27184774
57	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.26889868
58	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.26381083
59	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.25759407
60	SMAD4_21799915_ChIP-Seq_A2780_Human	1.24994967
61	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.23581976
62	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.22359241
63	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.21045903
64	ER_23166858_ChIP-Seq_MCF-7_Human	1.19064191
65	VDR_22108803_ChIP-Seq_LS180_Human	1.18250406
66	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.17966811
67	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.17865111
68	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.17411533
69	TCF4_23295773_ChIP-Seq_U87_Human	1.16393671
70	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.15894272
71	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.15885864
72	FOXP3_21729870_ChIP-Seq_TREG_Human	1.15527405
73	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.15287809
74	MYC_18940864_ChIP-ChIP_HL60_Human	1.12410953
75	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.11400394
76	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.11246633
77	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.09157920
78	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.08489772
79	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.08418060
80	CDX2_22108803_ChIP-Seq_LS180_Human	1.03961725
81	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.03593235
82	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.02240096
83	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.02147730
84	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.00016553
85	HTT_18923047_ChIP-ChIP_STHdh_Human	0.99841137
86	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.98727533
87	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.98700819
88	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.97943650
89	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.97673905
90	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.97338143
91	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.97148037
92	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.97114005
93	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.97114005
94	RUNX2_22187159_ChIP-Seq_PCA_Human	0.96908212
95	HOXB7_26014856_ChIP-Seq_BT474_Human	0.96541131
96	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.96538036
97	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.96330546
98	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.94368511
99	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.94134703
100	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.93659157

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	4.35054800
2	MP0003195_calcinosis	3.97546156
3	MP0005645_abnormal_hypothalamus_physiol	3.79810510
4	MP0002254_reproductive_system_inflammat	3.55728528
5	MP0003941_abnormal_skin_development	3.01723662
6	MP0008057_abnormal_DNA_replication	2.96241788
7	MP0006276_abnormal_autonomic_nervous	2.78523765
8	MP0008877_abnormal_DNA_methylation	2.74309243
9	MP0009780_abnormal_chondrocyte_physiolo	2.57866290
10	MP0008058_abnormal_DNA_repair	2.56936705
11	MP0001986_abnormal_taste_sensitivity	2.45017013
12	MP0003122_maternal_imprinting	2.44458109
13	MP0003011_delayed_dark_adaptation	2.30129867
14	MP0008995_early_reproductive_senescence	2.22083440
15	MP0003718_maternal_effect	2.08615501
16	MP0001486_abnormal_startle_reflex	2.05686176
17	MP0003786_premature_aging	2.00691333
18	MP0002938_white_spotting	1.93917808
19	MP0003121_genomic_imprinting	1.92065282
20	MP0008007_abnormal_cellular_replicative	1.90376044
21	MP0006292_abnormal_olfactory_placode	1.86957219
22	MP0010094_abnormal_chromosome_stability	1.72884426
23	MP0005379_endocrine/exocrine_gland_phen	1.68386609
24	MP0003693_abnormal_embryo_hatching	1.63470307
25	MP0003186_abnormal_redox_activity	1.60787160
26	MP0002837_dystrophic_cardiac_calcinosis	1.57155373
27	MP0001501_abnormal_sleep_pattern	1.55167542
28	MP0003880_abnormal_central_pattern	1.53675661
29	MP0001188_hyperpigmentation	1.47487630
30	MP0003111_abnormal_nucleus_morphology	1.46727266
31	MP0002736_abnormal_nociception_after	1.44531927
32	MP0005085_abnormal_gallbladder_physiolo	1.41944685
33	MP0001764_abnormal_homeostasis	1.41423880
34	MP0004019_abnormal_vitamin_homeostasis	1.35916847
35	MP0005551_abnormal_eye_electrophysiolog	1.35674373
36	MP0002396_abnormal_hematopoietic_system	1.29850129
37	MP0002090_abnormal_vision	1.29010057
38	MP0003123_paternal_imprinting	1.24963955
39	MP0004957_abnormal_blastocyst_morpholog	1.24321700
40	MP0001919_abnormal_reproductive_system	1.21945445
41	MP0001666_abnormal_nutrient_absorption	1.19229692
42	MP0004264_abnormal_extraembryonic_tissu	1.16542573
43	MP0002163_abnormal_gland_morphology	1.16513525
44	MP0009046_muscle_twitch	1.14979023
45	MP0005647_abnormal_sex_gland	1.13854176
46	MP0004215_abnormal_myocardial_fiber	1.13671963
47	MP0008872_abnormal_physiological_respon	1.13150846
48	MP0010329_abnormal_lipoprotein_level	1.12994880
49	MP0003787_abnormal_imprinting	1.12547168
50	MP0005253_abnormal_eye_physiology	1.08748203
51	MP0003077_abnormal_cell_cycle	1.07004625
52	MP0002751_abnormal_autonomic_nervous	1.05774315
53	MP0004085_abnormal_heartbeat	1.01787310
54	MP0004742_abnormal_vestibular_system	1.00529180
55	MP0003890_abnormal_embryonic-extraembry	0.97599881
56	MP0000427_abnormal_hair_cycle	0.96669380
57	MP0001485_abnormal_pinna_reflex	0.96355478
58	MP0003950_abnormal_plasma_membrane	0.96287786
59	MP0004043_abnormal_pH_regulation	0.96233923
60	MP0003937_abnormal_limbs/digits/tail_de	0.94227227
61	MP0001177_atelectasis	0.92390114
62	MP0005670_abnormal_white_adipose	0.91859948
63	MP0005365_abnormal_bile_salt	0.91830370
64	MP0002876_abnormal_thyroid_physiology	0.91635540
65	MP0002734_abnormal_mechanical_nocicepti	0.90082564
66	MP0005389_reproductive_system_phenotype	0.89847713
67	MP0001119_abnormal_female_reproductive	0.89189780
68	MP0003567_abnormal_fetal_cardiomyocyte	0.88855661
69	MP0002557_abnormal_social/conspecific_i	0.88613038
70	MP0001968_abnormal_touch/_nociception	0.87528220
71	MP0002735_abnormal_chemical_nociception	0.87216122
72	MP0004883_abnormal_blood_vessel	0.86103847
73	MP0002638_abnormal_pupillary_reflex	0.85792310
74	MP0000647_abnormal_sebaceous_gland	0.84608653
75	MP0005408_hypopigmentation	0.84218397
76	MP0002272_abnormal_nervous_system	0.82209823
77	MP0002210_abnormal_sex_determination	0.81525258
78	MP0001984_abnormal_olfaction	0.80263583
79	MP0009745_abnormal_behavioral_response	0.80053829
80	MP0005367_renal/urinary_system_phenotyp	0.79643519
81	MP0000516_abnormal_urinary_system	0.79643519
82	MP0005332_abnormal_amino_acid	0.79098179
83	MP0001529_abnormal_vocalization	0.78397593
84	MP0000230_abnormal_systemic_arterial	0.78296471
85	MP0002295_abnormal_pulmonary_circulatio	0.77924897
86	MP0005636_abnormal_mineral_homeostasis	0.77059614
87	MP0005395_other_phenotype	0.76072146
88	MP0001929_abnormal_gametogenesis	0.74380579
89	MP0000639_abnormal_adrenal_gland	0.73422216
90	MP0004133_heterotaxia	0.72167561
91	MP0000653_abnormal_sex_gland	0.72137284
92	MP0002067_abnormal_sensory_capabilities	0.71563076
93	MP0010386_abnormal_urinary_bladder	0.70265479
94	MP0005330_cardiomyopathy	0.69561061
95	MP0008775_abnormal_heart_ventricle	0.67975442
96	MP0002733_abnormal_thermal_nociception	0.67855273
97	MP0008932_abnormal_embryonic_tissue	0.67765054
98	MP0006054_spinal_hemorrhage	0.66498991
99	MP0001661_extended_life_span	0.66233272
100	MP0000631_abnormal_neuroendocrine_gland	0.64904956

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital sensorineural hearing impairment (HP:0008527)	4.43635126
2	Pancreatic islet-cell hyperplasia (HP:0004510)	4.36273569
3	Abnormal sex determination (HP:0012244)	3.79587527
4	Sex reversal (HP:0012245)	3.79587527
5	Hypoplastic pelvis (HP:0008839)	3.61161582
6	Hypobetalipoproteinemia (HP:0003563)	3.59284323
7	Steatorrhea (HP:0002570)	3.42222193
8	Supernumerary spleens (HP:0009799)	3.32457959
9	Hypoglycemic coma (HP:0001325)	3.31700376
10	Abnormality of vitamin B metabolism (HP:0004340)	3.27761803
11	Hypoglycemic seizures (HP:0002173)	3.24008013
12	Chronic hepatic failure (HP:0100626)	3.19827000
13	Meckel diverticulum (HP:0002245)	3.16907465
14	Gonadotropin excess (HP:0000837)	3.15272059
15	Hyperinsulinemic hypoglycemia (HP:0000825)	3.12866935
16	Intestinal atresia (HP:0011100)	3.12543611
17	Abnormality of the ileum (HP:0001549)	3.06094545
18	Proximal tubulopathy (HP:0000114)	2.99391074
19	Fat malabsorption (HP:0002630)	2.97698698
20	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.84319320
21	Hyperventilation (HP:0002883)	2.83985691
22	Abnormality of macular pigmentation (HP:0008002)	2.82459050
23	Methylmalonic acidemia (HP:0002912)	2.79730389
24	Increased CSF lactate (HP:0002490)	2.79195662
25	Acute encephalopathy (HP:0006846)	2.66789484
26	Cerebellar dysplasia (HP:0007033)	2.59160912
27	Bifid tongue (HP:0010297)	2.58063807
28	Abnormality of the labia minora (HP:0012880)	2.50650390
29	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.49923829
30	True hermaphroditism (HP:0010459)	2.48732115
31	Hypolipoproteinemia (HP:0010981)	2.46791372
32	Progressive inability to walk (HP:0002505)	2.46082293
33	Nausea (HP:0002018)	2.45802700
34	Abnormality of chromosome stability (HP:0003220)	2.45124834
35	Type II lissencephaly (HP:0007260)	2.44414572
36	Concave nail (HP:0001598)	2.34217354
37	Abnormality of urine glucose concentration (HP:0011016)	2.31718314
38	Glycosuria (HP:0003076)	2.31718314
39	Gonadal dysgenesis (HP:0000133)	2.29824520
40	Abnormality of the preputium (HP:0100587)	2.27054081
41	Methylmalonic aciduria (HP:0012120)	2.21190256
42	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.18218812
43	Abnormality of the duodenum (HP:0002246)	2.17959302
44	Stenosis of the external auditory canal (HP:0000402)	2.14955921
45	Patchy hypopigmentation of hair (HP:0011365)	2.14705043
46	Abnormal gallbladder physiology (HP:0012438)	2.11711156
47	Cholecystitis (HP:0001082)	2.11711156
48	Exercise-induced muscle cramps (HP:0003710)	2.08163474
49	Abnormality of glycolysis (HP:0004366)	2.07374547
50	Neonatal respiratory distress (HP:0002643)	2.05519545
51	Muscular hypotonia of the trunk (HP:0008936)	2.05132020
52	Abnormality of vitamin metabolism (HP:0100508)	2.02737533
53	Symptomatic seizures (HP:0011145)	2.02582233
54	Abnormality of methionine metabolism (HP:0010901)	2.02370923
55	Hepatoblastoma (HP:0002884)	2.02059125
56	Spontaneous abortion (HP:0005268)	2.00491999
57	Pendular nystagmus (HP:0012043)	2.00299425
58	Tongue fasciculations (HP:0001308)	1.99840965
59	Hyperglycinemia (HP:0002154)	1.97858891
60	Aqueductal stenosis (HP:0002410)	1.97072531
61	Increased hepatocellular lipid droplets (HP:0006565)	1.96407272
62	Renal cortical cysts (HP:0000803)	1.95604891
63	Hypoplastic female external genitalia (HP:0012815)	1.94060869
64	Abnormal lung lobation (HP:0002101)	1.91446550
65	Lipid accumulation in hepatocytes (HP:0006561)	1.89133598
66	Hepatocellular necrosis (HP:0001404)	1.88773302
67	Chorioretinal atrophy (HP:0000533)	1.88452909
68	Abolished electroretinogram (ERG) (HP:0000550)	1.88137999
69	Duodenal stenosis (HP:0100867)	1.87954918
70	Small intestinal stenosis (HP:0012848)	1.87954918
71	Hepatic necrosis (HP:0002605)	1.87555594
72	Generalized myoclonic seizures (HP:0002123)	1.87347719
73	Severe muscular hypotonia (HP:0006829)	1.85757206
74	Abnormality of endocrine pancreas physiology (HP:0012093)	1.84891364
75	Abnormality of the pancreatic islet cells (HP:0006476)	1.84891364
76	Poor eye contact (HP:0000817)	1.84350932
77	Labial hypoplasia (HP:0000066)	1.84012049
78	Abnormality of serum amino acid levels (HP:0003112)	1.83069287
79	Mitochondrial inheritance (HP:0001427)	1.82708642
80	Clitoromegaly (HP:0000057)	1.82294549
81	Colon cancer (HP:0003003)	1.82130223
82	Abnormality of the clitoris (HP:0000056)	1.81853442
83	Neoplasm of the adrenal gland (HP:0100631)	1.81396858
84	Global brain atrophy (HP:0002283)	1.80770673
85	Pancreatic cysts (HP:0001737)	1.79285676
86	Increased serum lactate (HP:0002151)	1.79115859
87	Progressive external ophthalmoplegia (HP:0000590)	1.78931347
88	Hypokinesia (HP:0002375)	1.77565659
89	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	1.77287637
90	Secondary amenorrhea (HP:0000869)	1.76589558
91	Oligodactyly (hands) (HP:0001180)	1.70912078
92	Clubbing of toes (HP:0100760)	1.69448595
93	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.69149830
94	Medial flaring of the eyebrow (HP:0010747)	1.68037428
95	Megaloblastic anemia (HP:0001889)	1.66943199
96	Spastic paraparesis (HP:0002313)	1.66837787
97	Intrahepatic cholestasis (HP:0001406)	1.66747211
98	Scrotal hypoplasia (HP:0000046)	1.65757055
99	Adrenal hypoplasia (HP:0000835)	1.63400572
100	White forelock (HP:0002211)	1.63034256

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIM28	5.28167455
2	FRK	4.20235889
3	BMPR1B	3.57845958
4	ACVR1B	3.23642853
5	PBK	2.98665581
6	TSSK6	2.93573732
7	BUB1	2.70341300
8	MST4	2.65294027
9	WEE1	2.30275015
10	PNCK	2.22836497
11	PDK2	2.13844713
12	EIF2AK1	1.88845899
13	EIF2AK3	1.83433923
14	PLK3	1.81819051
15	ERBB3	1.78592541
16	DYRK3	1.70455351
17	GRK1	1.68696206
18	INSRR	1.68611247
19	TGFBR1	1.67227096
20	CASK	1.66114730
21	MKNK2	1.65697449
22	PLK2	1.64042440
23	MAP3K12	1.53400892
24	ZAK	1.52449673
25	MKNK1	1.49296482
26	BRD4	1.43907474
27	PRKCE	1.42517748
28	TNIK	1.39609340
29	WNK3	1.39134996
30	FGFR2	1.38545211
31	NEK1	1.30035444
32	STK16	1.24648952
33	NUAK1	1.23378101
34	ADRBK2	1.20905482
35	VRK1	1.10088679
36	CSNK1G1	1.01346125
37	PAK3	1.01074161
38	STK3	0.94993525
39	TIE1	0.88887973
40	PRKD3	0.88218744
41	PLK4	0.87966294
42	NLK	0.85731352
43	PRKCG	0.84999478
44	PLK1	0.83662524
45	TTK	0.81009235
46	PRKCI	0.76353282
47	BRSK2	0.75068110
48	FGR	0.73658962
49	MAPK13	0.73482088
50	TAOK3	0.73412320
51	FER	0.72603983
52	ERBB4	0.69753607
53	DYRK1A	0.67613727
54	AKT3	0.67342324
55	MARK1	0.66341446
56	SRPK1	0.61648118
57	YES1	0.61089303
58	ATM	0.60054973
59	PINK1	0.58611812
60	FLT3	0.57981926
61	CSNK1A1L	0.57666658
62	MAP4K2	0.57277277
63	EIF2AK2	0.56395664
64	CSNK1G2	0.52646279
65	EPHA4	0.51747420
66	PRKACB	0.51709601
67	STK4	0.51201327
68	CSNK2A1	0.50985660
69	CSNK1G3	0.49913004
70	DAPK2	0.46097949
71	ADRBK1	0.43714758
72	CSNK1A1	0.42954135
73	NME1	0.42831683
74	ATR	0.41393351
75	CSNK2A2	0.41313622
76	RPS6KA5	0.41259352
77	SGK223	0.40608461
78	SGK494	0.40608461
79	CSNK1D	0.40098245
80	FGFR1	0.38058962
81	NTRK3	0.37306924
82	MAP3K4	0.36746798
83	STK39	0.36673097
84	CHEK2	0.34784912
85	PRKG1	0.34485712
86	SGK2	0.33877817
87	OBSCN	0.33154526
88	CDK7	0.32223033
89	CSNK1E	0.31147849
90	PRKCB	0.30932561
91	EGFR	0.30782372
92	PRKDC	0.30222802
93	BCR	0.29751198
94	CDK8	0.28807917
95	DAPK1	0.28485598
96	PRKACA	0.28054195
97	OXSR1	0.27799924
98	PRKCA	0.26776339
99	PIM1	0.26068796
100	AURKB	0.25619898

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.71007440
2	Propanoate metabolism_Homo sapiens_hsa00640	2.97796580
3	Protein export_Homo sapiens_hsa03060	2.81451190
4	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.78878232
5	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.64508926
6	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.47280915
7	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.20613260
8	Butanoate metabolism_Homo sapiens_hsa00650	2.15454689
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.04415373
10	One carbon pool by folate_Homo sapiens_hsa00670	2.04135309
11	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.95702321
12	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.94198699
13	Proteasome_Homo sapiens_hsa03050	1.90396615
14	Sulfur metabolism_Homo sapiens_hsa00920	1.86787293
15	Nitrogen metabolism_Homo sapiens_hsa00910	1.86143705
16	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.83706206
17	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.82935425
18	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.79378566
19	Selenocompound metabolism_Homo sapiens_hsa00450	1.75652970
20	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.74337244
21	Basal transcription factors_Homo sapiens_hsa03022	1.70212727
22	Peroxisome_Homo sapiens_hsa04146	1.65723205
23	Glutathione metabolism_Homo sapiens_hsa00480	1.64387790
24	Homologous recombination_Homo sapiens_hsa03440	1.63352277
25	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.60310076
26	Non-homologous end-joining_Homo sapiens_hsa03450	1.55077275
27	Fatty acid elongation_Homo sapiens_hsa00062	1.52310047
28	Chemical carcinogenesis_Homo sapiens_hsa05204	1.49923518
29	Fat digestion and absorption_Homo sapiens_hsa04975	1.46428313
30	Mismatch repair_Homo sapiens_hsa03430	1.40937137
31	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.38230254
32	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.37596144
33	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.37587092
34	RNA degradation_Homo sapiens_hsa03018	1.37002284
35	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.36164836
36	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.35061329
37	Carbon metabolism_Homo sapiens_hsa01200	1.34787757
38	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.30965816
39	Retinol metabolism_Homo sapiens_hsa00830	1.25660784
40	Arginine biosynthesis_Homo sapiens_hsa00220	1.21345489
41	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.19908683
42	RNA transport_Homo sapiens_hsa03013	1.16158713
43	Fatty acid degradation_Homo sapiens_hsa00071	1.11131503
44	Caffeine metabolism_Homo sapiens_hsa00232	1.10016437
45	Oxidative phosphorylation_Homo sapiens_hsa00190	1.09766769
46	RNA polymerase_Homo sapiens_hsa03020	1.09665746
47	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.09018022
48	beta-Alanine metabolism_Homo sapiens_hsa00410	1.07959313
49	ABC transporters_Homo sapiens_hsa02010	1.06005048
50	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.05727116
51	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.05672985
52	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.04102125
53	Tryptophan metabolism_Homo sapiens_hsa00380	0.99280740
54	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.98430964
55	Ether lipid metabolism_Homo sapiens_hsa00565	0.96995375
56	Parkinsons disease_Homo sapiens_hsa05012	0.95011000
57	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.93071129
58	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.91110443
59	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.90458581
60	Fatty acid metabolism_Homo sapiens_hsa01212	0.86737745
61	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.84045344
62	Nicotine addiction_Homo sapiens_hsa05033	0.74419719
63	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.74216223
64	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.73307564
65	DNA replication_Homo sapiens_hsa03030	0.71381359
66	Pyruvate metabolism_Homo sapiens_hsa00620	0.69300729
67	Metabolic pathways_Homo sapiens_hsa01100	0.67591802
68	Purine metabolism_Homo sapiens_hsa00230	0.64049217
69	Linoleic acid metabolism_Homo sapiens_hsa00591	0.62227625
70	Nucleotide excision repair_Homo sapiens_hsa03420	0.61127896
71	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.60488073
72	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.55645729
73	p53 signaling pathway_Homo sapiens_hsa04115	0.53097316
74	Glycerolipid metabolism_Homo sapiens_hsa00561	0.52583709
75	Arginine and proline metabolism_Homo sapiens_hsa00330	0.52506694
76	Oocyte meiosis_Homo sapiens_hsa04114	0.51664085
77	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.51062508
78	Regulation of autophagy_Homo sapiens_hsa04140	0.50494197
79	Cell cycle_Homo sapiens_hsa04110	0.49087028
80	Mineral absorption_Homo sapiens_hsa04978	0.48118790
81	Phototransduction_Homo sapiens_hsa04744	0.46274264
82	PPAR signaling pathway_Homo sapiens_hsa03320	0.46165611
83	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.45564961
84	Pyrimidine metabolism_Homo sapiens_hsa00240	0.45157566
85	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.44582490
86	Huntingtons disease_Homo sapiens_hsa05016	0.43594081
87	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.39296622
88	Base excision repair_Homo sapiens_hsa03410	0.38639742
89	Taste transduction_Homo sapiens_hsa04742	0.38611204
90	Alzheimers disease_Homo sapiens_hsa05010	0.36633408
91	Spliceosome_Homo sapiens_hsa03040	0.33876273
92	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.33621670
93	Tight junction_Homo sapiens_hsa04530	0.33577505
94	Histidine metabolism_Homo sapiens_hsa00340	0.31151830
95	GABAergic synapse_Homo sapiens_hsa04727	0.29327945
96	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.28687892
97	Serotonergic synapse_Homo sapiens_hsa04726	0.27788116
98	Sphingolipid metabolism_Homo sapiens_hsa00600	0.26492836
99	Steroid biosynthesis_Homo sapiens_hsa00100	0.25203515
100	Collecting duct acid secretion_Homo sapiens_hsa04966	0.24755428

BNIP3P22

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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