BNIP3P25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tachykinin receptor signaling pathway (GO:0007217)7.20450918
2positive regulation of uterine smooth muscle contraction (GO:0070474)6.04390575
3neural tube formation (GO:0001841)5.70521319
4RNA destabilization (GO:0050779)5.46876137
5positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)5.37743102
6regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)5.37743102
7regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)4.89925687
8positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO4.89925687
9positive regulation of mRNA catabolic process (GO:0061014)4.80278486
10protein K11-linked deubiquitination (GO:0035871)4.66433819
11activation of MAPKKK activity (GO:0000185)4.33431766
12positive regulation of dendritic spine morphogenesis (GO:0061003)4.31958464
13positive regulation of mRNA processing (GO:0050685)4.24907670
14G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.18725940
15regulation of uterine smooth muscle contraction (GO:0070472)4.18354293
16hyperosmotic salinity response (GO:0042538)4.15883225
17regulation of catecholamine metabolic process (GO:0042069)4.15222282
18regulation of dopamine metabolic process (GO:0042053)4.15222282
19positive regulation of mRNA metabolic process (GO:1903313)4.09114304
20cellular response to zinc ion (GO:0071294)4.07857868
21positive regulation of mRNA 3-end processing (GO:0031442)4.05319986
22regulation of mRNA catabolic process (GO:0061013)4.03450716
23platelet dense granule organization (GO:0060155)3.94348681
24olfactory bulb development (GO:0021772)3.83980439
25serotonin metabolic process (GO:0042428)3.76036426
26regulation of feeding behavior (GO:0060259)3.72526404
27positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.69995869
28mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.69995869
29dopamine biosynthetic process (GO:0042416)3.67943182
30histone mRNA catabolic process (GO:0071044)3.60275276
31secretory granule organization (GO:0033363)3.59823456
32lymphoid progenitor cell differentiation (GO:0002320)3.57765376
33regulation of mRNA 3-end processing (GO:0031440)3.55286994
34regulation of collateral sprouting (GO:0048670)3.53337788
35primary amino compound metabolic process (GO:1901160)3.50235155
36fibroblast migration (GO:0010761)3.47638353
37positive regulation of dendritic spine development (GO:0060999)3.44149744
38negative regulation of neurotransmitter transport (GO:0051589)3.40868599
39central nervous system projection neuron axonogenesis (GO:0021952)3.38486649
40cerebral cortex radially oriented cell migration (GO:0021799)3.28425060
41glial cell proliferation (GO:0014009)3.22073218
42positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.21634100
43short-term memory (GO:0007614)3.21288036
44neuronal action potential (GO:0019228)3.20788345
45L-fucose catabolic process (GO:0042355)3.17934544
46fucose catabolic process (GO:0019317)3.17934544
47L-fucose metabolic process (GO:0042354)3.17934544
48phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.17823899
49mRNA splice site selection (GO:0006376)3.12436333
50regulation of cAMP-dependent protein kinase activity (GO:2000479)3.12215104
51histone H3-K4 trimethylation (GO:0080182)3.10663656
52negative regulation of alpha-beta T cell differentiation (GO:0046639)3.10511806
53central nervous system neuron axonogenesis (GO:0021955)3.07867531
54monoubiquitinated protein deubiquitination (GO:0035520)3.07431922
55limb bud formation (GO:0060174)3.06477633
56positive regulation of vasculogenesis (GO:2001214)3.01910340
57positive regulation of macrophage cytokine production (GO:0060907)3.00231759
58cerebellar Purkinje cell differentiation (GO:0021702)2.98804589
59polyol transport (GO:0015791)2.97673940
60myelin assembly (GO:0032288)2.95344697
61dopamine transport (GO:0015872)2.94998540
62catechol-containing compound biosynthetic process (GO:0009713)2.94536097
63catecholamine biosynthetic process (GO:0042423)2.94536097
64regulation of inositol phosphate biosynthetic process (GO:0010919)2.93544340
65cytoplasmic mRNA processing body assembly (GO:0033962)2.92382034
66establishment of protein localization to Golgi (GO:0072600)2.90203076
67microtubule polymerization or depolymerization (GO:0031109)2.89265374
68microtubule anchoring (GO:0034453)2.85541420
69epithelial cell differentiation involved in kidney development (GO:0035850)2.82832131
70somite development (GO:0061053)2.81318793
71embryonic hemopoiesis (GO:0035162)2.76793523
72microglial cell activation (GO:0001774)2.74680950
73protein targeting to Golgi (GO:0000042)2.74098368
74centrosome localization (GO:0051642)2.70900730
75response to hydroperoxide (GO:0033194)2.70316247
76single strand break repair (GO:0000012)2.66945726
77germ cell migration (GO:0008354)2.66919120
78sympathetic nervous system development (GO:0048485)2.64947963
79regulation of pigment cell differentiation (GO:0050932)2.64227622
80response to cocaine (GO:0042220)2.61485167
81positive regulation of smooth muscle contraction (GO:0045987)2.60618671
82mitotic sister chromatid cohesion (GO:0007064)2.59005329
83behavioral response to nicotine (GO:0035095)2.57713911
84retrograde transport, vesicle recycling within Golgi (GO:0000301)2.57598776
85response to nitrosative stress (GO:0051409)2.57459717
86positive T cell selection (GO:0043368)2.56709884
87DNA integration (GO:0015074)2.55019933
88nonmotile primary cilium assembly (GO:0035058)2.53377980
89peptidyl-lysine trimethylation (GO:0018023)2.53198006
90positive regulation of dendrite morphogenesis (GO:0050775)2.52269989
91regulation of MHC class II biosynthetic process (GO:0045346)2.51179640
92intraciliary transport (GO:0042073)2.50543083
93pantothenate metabolic process (GO:0015939)2.49917401
94forebrain neuron differentiation (GO:0021879)2.49786742
95nerve growth factor signaling pathway (GO:0038180)2.48740655
96positive regulation of developmental pigmentation (GO:0048087)2.46482993
97detection of molecule of bacterial origin (GO:0032490)2.44236825
98regulation of dendritic spine development (GO:0060998)2.42671225
99cellular response to ethanol (GO:0071361)2.41403711
100adaptation of signaling pathway (GO:0023058)11.1457869

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human4.54742961
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.94585086
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.81755547
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.49752235
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.27052124
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.19692495
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.97563270
8TAF15_26573619_Chip-Seq_HEK293_Human2.95825091
9GBX2_23144817_ChIP-Seq_PC3_Human2.83188256
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.80547134
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.67840630
12FUS_26573619_Chip-Seq_HEK293_Human2.52081682
13EZH2_22144423_ChIP-Seq_EOC_Human2.35785713
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.13832419
15ZNF274_21170338_ChIP-Seq_K562_Hela2.11398315
16AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.08924177
17P300_19829295_ChIP-Seq_ESCs_Human2.05887162
18SMAD_19615063_ChIP-ChIP_OVARY_Human1.97895673
19SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.96980205
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92064589
21OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.89242785
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.87494373
23MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.83493973
24EWS_26573619_Chip-Seq_HEK293_Human1.82557566
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79259312
26STAT3_23295773_ChIP-Seq_U87_Human1.76563538
27AR_21572438_ChIP-Seq_LNCaP_Human1.74021191
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73753742
29SMAD4_21799915_ChIP-Seq_A2780_Human1.71040715
30SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68546716
31TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.60469141
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60077743
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.60052218
34NANOG_18555785_Chip-Seq_ESCs_Mouse1.57013902
35POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.57010604
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57010604
37SMAD3_21741376_ChIP-Seq_EPCs_Human1.55600530
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55276783
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.53738546
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.50771604
41VDR_22108803_ChIP-Seq_LS180_Human1.49389821
42ER_23166858_ChIP-Seq_MCF-7_Human1.49182009
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47429975
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46327253
45AR_25329375_ChIP-Seq_VCAP_Human1.45529536
46RUNX2_22187159_ChIP-Seq_PCA_Human1.43893637
47CBP_20019798_ChIP-Seq_JUKART_Human1.41961565
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41961565
49TP53_16413492_ChIP-PET_HCT116_Human1.41560148
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39892822
51NR3C1_21868756_ChIP-Seq_MCF10A_Human1.39231850
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39146791
53EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.36429233
54FLI1_21867929_ChIP-Seq_TH2_Mouse1.35200650
55E2F1_18555785_Chip-Seq_ESCs_Mouse1.33404423
56TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.32339792
57P53_22387025_ChIP-Seq_ESCs_Mouse1.31834064
58HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31136426
59TCF4_23295773_ChIP-Seq_U87_Human1.29813353
60HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.29460238
61CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.29026548
62STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.28732483
63PRDM14_20953172_ChIP-Seq_ESCs_Human1.26395763
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.25018203
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23582478
66TAL1_26923725_Chip-Seq_HPCs_Mouse1.23458273
67FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.23391790
68KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.23340495
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.20613224
70CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.20437901
71SOX2_21211035_ChIP-Seq_LN229_Gbm1.14886950
72RNF2_27304074_Chip-Seq_NSC_Mouse1.13947067
73STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.12982092
74STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.12960084
75TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.12909036
76SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11758949
77LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10931442
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08989601
79CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08547442
80TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07669278
81CMYC_18555785_Chip-Seq_ESCs_Mouse1.07018336
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05440490
83CRX_20693478_ChIP-Seq_RETINA_Mouse1.04272908
84MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04080328
85EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03792480
86P300_18555785_Chip-Seq_ESCs_Mouse1.03235834
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02775467
88NFE2_27457419_Chip-Seq_LIVER_Mouse1.00753934
89MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00182115
90STAT3_18555785_Chip-Seq_ESCs_Mouse1.00153280
91ELK1_19687146_ChIP-ChIP_HELA_Human0.99800464
92BCAT_22108803_ChIP-Seq_LS180_Human0.99199375
93ARNT_22903824_ChIP-Seq_MCF-7_Human0.97676731
94Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97391493
95SMAD4_21741376_ChIP-Seq_EPCs_Human0.97245365
96OCT4_18555785_Chip-Seq_ESCs_Mouse0.96721362
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96133008
98OCT4_21477851_ChIP-Seq_ESCs_Mouse0.95990328
99PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94396788
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94270589

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.14623066
2MP0002234_abnormal_pharynx_morphology3.74423712
3MP0005174_abnormal_tail_pigmentation3.02661820
4MP0003787_abnormal_imprinting2.85051900
5MP0000015_abnormal_ear_pigmentation2.81605127
6MP0000372_irregular_coat_pigmentation2.17584630
7MP0000569_abnormal_digit_pigmentation11.1339770
8MP0002102_abnormal_ear_morphology1.96912466
9MP0009697_abnormal_copulation1.95560505
10MP0003890_abnormal_embryonic-extraembry1.93303802
11MP0003221_abnormal_cardiomyocyte_apopto1.90026519
12MP0002751_abnormal_autonomic_nervous1.74058893
13MP0001879_abnormal_lymphatic_vessel1.70763428
14MP0001968_abnormal_touch/_nociception1.61553171
15MP0002177_abnormal_outer_ear1.58355605
16MP0002009_preneoplasia1.55924007
17MP0002095_abnormal_skin_pigmentation1.55798466
18MP0003195_calcinosis1.55146916
19MP0003121_genomic_imprinting1.54799475
20MP0005187_abnormal_penis_morphology1.53313168
21MP0000383_abnormal_hair_follicle1.52413532
22MP0004484_altered_response_of1.52309904
23MP0005075_abnormal_melanosome_morpholog1.49566645
24MP0008877_abnormal_DNA_methylation1.45495022
25MP0001188_hyperpigmentation1.45244111
26MP0002736_abnormal_nociception_after1.38705713
27MP0003880_abnormal_central_pattern1.37284694
28MP0008995_early_reproductive_senescence1.34140606
29MP0008260_abnormal_autophagy1.30488884
30MP0003937_abnormal_limbs/digits/tail_de1.29877628
31MP0000778_abnormal_nervous_system1.26775856
32MP0005171_absent_coat_pigmentation1.24386788
33MP0003828_pulmonary_edema1.22103956
34MP0003724_increased_susceptibility_to1.20413894
35MP0002254_reproductive_system_inflammat1.17838870
36MP0000371_diluted_coat_color1.17357371
37MP0009745_abnormal_behavioral_response1.16244099
38MP0004883_abnormal_blood_vessel1.15712948
39MP0004742_abnormal_vestibular_system1.12871766
40MP0006054_spinal_hemorrhage1.11996662
41MP0010678_abnormal_skin_adnexa1.10653288
42MP0002168_other_aberrant_phenotype1.06629395
43MP0001486_abnormal_startle_reflex1.03667562
44MP0003950_abnormal_plasma_membrane1.00905341
45MP0005386_behavior/neurological_phenoty0.98935881
46MP0004924_abnormal_behavior0.98935881
47MP0002928_abnormal_bile_duct0.98056639
48MP0006292_abnormal_olfactory_placode0.97950837
49MP0002396_abnormal_hematopoietic_system0.97793658
50MP0003935_abnormal_craniofacial_develop0.96673764
51MP0004147_increased_porphyrin_level0.94410592
52MP0003119_abnormal_digestive_system0.93899218
53MP0003567_abnormal_fetal_cardiomyocyte0.91586951
54MP0001800_abnormal_humoral_immune0.89477862
55MP0003122_maternal_imprinting0.89114976
56MP0002067_abnormal_sensory_capabilities0.87345360
57MP0003091_abnormal_cell_migration0.85556509
58MP0004134_abnormal_chest_morphology0.85189498
59MP0002933_joint_inflammation0.83932138
60MP0001905_abnormal_dopamine_level0.83434717
61MP0001529_abnormal_vocalization0.83085685
62MP0002075_abnormal_coat/hair_pigmentati0.82561972
63MP0004381_abnormal_hair_follicle0.80820801
64MP0001299_abnormal_eye_distance/0.78780668
65MP0004133_heterotaxia0.78725063
66MP0000427_abnormal_hair_cycle0.78693172
67MP0003755_abnormal_palate_morphology0.77947404
68MP0002332_abnormal_exercise_endurance0.77834778
69MP0005248_abnormal_Harderian_gland0.77563113
70MP0001324_abnormal_eye_pigmentation0.77264397
71MP0005220_abnormal_exocrine_pancreas0.76442737
72MP0003943_abnormal_hepatobiliary_system0.76400147
73MP0004130_abnormal_muscle_cell0.75315878
74MP0000631_abnormal_neuroendocrine_gland0.74917178
75MP0002295_abnormal_pulmonary_circulatio0.74735205
76MP0010368_abnormal_lymphatic_system0.74298716
77MP0004808_abnormal_hematopoietic_stem0.72637190
78MP0001986_abnormal_taste_sensitivity0.72512431
79MP0002272_abnormal_nervous_system0.71462736
80MP0002063_abnormal_learning/memory/cond0.69920026
81MP0004043_abnormal_pH_regulation0.69608070
82MP0000049_abnormal_middle_ear0.68706025
83MP0000749_muscle_degeneration0.66905853
84MP0003303_peritoneal_inflammation0.65346835
85MP0001293_anophthalmia0.64829291
86MP0001186_pigmentation_phenotype0.64805808
87MP0000639_abnormal_adrenal_gland0.61620114
88MP0008961_abnormal_basal_metabolism0.61129181
89MP0002909_abnormal_adrenal_gland0.60662970
90MP0002938_white_spotting0.58555982
91MP0002069_abnormal_eating/drinking_beha0.56773770
92MP0000689_abnormal_spleen_morphology0.56588468
93MP0003635_abnormal_synaptic_transmissio0.56097433
94MP0002109_abnormal_limb_morphology0.55990269
95MP0002572_abnormal_emotion/affect_behav0.55678667
96MP0005310_abnormal_salivary_gland0.55654892
97MP0002098_abnormal_vibrissa_morphology0.53915646
98MP0008058_abnormal_DNA_repair0.53724396
99MP0005464_abnormal_platelet_physiology0.52431040
100MP0002733_abnormal_thermal_nociception0.51985625

Predicted human phenotypes

RankGene SetZ-score
1Fetal akinesia sequence (HP:0001989)3.80753757
2Papillary thyroid carcinoma (HP:0002895)3.69334091
3Acute lymphatic leukemia (HP:0006721)3.61139717
4Tented upper lip vermilion (HP:0010804)3.57972759
5Thyroiditis (HP:0100646)3.15150374
6Pancreatic cysts (HP:0001737)3.13319791
7Diastasis recti (HP:0001540)3.06387091
8Popliteal pterygium (HP:0009756)3.05200240
9Curly hair (HP:0002212)2.95990638
10Type 2 muscle fiber atrophy (HP:0003554)2.95808237
11Hepatoblastoma (HP:0002884)2.95364886
12Exotropia (HP:0000577)2.91455524
13Stomach cancer (HP:0012126)2.85578834
14Gaze-evoked nystagmus (HP:0000640)2.82454493
15Hypothermia (HP:0002045)2.79452246
16Pancreatic fibrosis (HP:0100732)2.73112003
17Retinal atrophy (HP:0001105)2.63298562
18Generalized hypopigmentation (HP:0007513)2.62019625
19Atonic seizures (HP:0010819)2.61018857
20Cystic hygroma (HP:0000476)2.59214471
21Tubulointerstitial nephritis (HP:0001970)2.58581680
22Generalized hypopigmentation of hair (HP:0011358)2.50642344
23Progressive cerebellar ataxia (HP:0002073)2.50031164
24Fair hair (HP:0002286)2.49090619
25Thyroid carcinoma (HP:0002890)2.46316944
26Abnormality of the renal medulla (HP:0100957)2.46042197
27Hyperventilation (HP:0002883)2.45985921
28Supernumerary spleens (HP:0009799)2.45589290
29Chronic hepatic failure (HP:0100626)2.44305144
30Hypoplastic iliac wings (HP:0002866)2.37689813
31Albinism (HP:0001022)2.33062780
32Poor coordination (HP:0002370)2.28970346
33Akinesia (HP:0002304)2.26860549
34Abnormality of chromosome stability (HP:0003220)2.26770032
35Nephronophthisis (HP:0000090)2.26251159
36Aplasia/Hypoplasia of the tongue (HP:0010295)2.25531668
37Decreased testicular size (HP:0008734)2.23821390
38Colon cancer (HP:0003003)2.22375137
39Medial flaring of the eyebrow (HP:0010747)2.21956634
40Bladder neoplasm (HP:0009725)2.19577852
41Bladder carcinoma (HP:0002862)2.19577852
42Neoplasm of the tracheobronchial system (HP:0100552)2.12942092
43Muscle fiber atrophy (HP:0100295)2.12295475
44Focal motor seizures (HP:0011153)2.12027263
45Intellectual disability, moderate (HP:0002342)2.11893386
46Congenital primary aphakia (HP:0007707)2.11810586
47Degeneration of the lateral corticospinal tracts (HP:0002314)2.11407081
48Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.11407081
49Neoplasm of the adrenal cortex (HP:0100641)2.10097784
50Gait imbalance (HP:0002141)2.08498895
51Amyotrophic lateral sclerosis (HP:0007354)2.06320954
52True hermaphroditism (HP:0010459)2.04427417
53Long clavicles (HP:0000890)2.03223324
54Neonatal hypoglycemia (HP:0001998)2.02746097
55Hyperglycinemia (HP:0002154)2.01657450
56Metaphyseal dysplasia (HP:0100255)2.01099047
57Aplasia/Hypoplasia of the tibia (HP:0005772)1.99479279
58Facial hemangioma (HP:0000329)1.99162345
59Absent speech (HP:0001344)1.97378297
60Nephrogenic diabetes insipidus (HP:0009806)1.96240400
61Stomatitis (HP:0010280)1.94729687
62Medulloblastoma (HP:0002885)1.94148195
63Transitional cell carcinoma of the bladder (HP:0006740)1.91325733
64Arterial tortuosity (HP:0005116)1.90096149
65Intestinal atresia (HP:0011100)1.88564095
66Spontaneous hematomas (HP:0007420)1.88127973
67Severe combined immunodeficiency (HP:0004430)1.82477950
68Fatigable weakness (HP:0003473)1.81957220
69Abnormality of the neuromuscular junction (HP:0003398)1.81957220
70Specific learning disability (HP:0001328)1.81718153
71Abnormality of the labia minora (HP:0012880)1.81474444
72Drooling (HP:0002307)1.80959451
73Hip dysplasia (HP:0001385)1.80904755
74Dyschromatopsia (HP:0007641)1.79741248
75Abnormality of midbrain morphology (HP:0002418)1.78892185
76Molar tooth sign on MRI (HP:0002419)1.78892185
77Abnormal biliary tract physiology (HP:0012439)1.78661579
78Bile duct proliferation (HP:0001408)1.78661579
79Depressed nasal tip (HP:0000437)1.77455322
80Decreased muscle mass (HP:0003199)1.77276904
81Attenuation of retinal blood vessels (HP:0007843)1.77239758
82Ocular albinism (HP:0001107)1.74587037
83Aplasia/Hypoplasia involving the musculature (HP:0001460)1.73844707
84Febrile seizures (HP:0002373)1.73295045
85Abolished electroretinogram (ERG) (HP:0000550)1.72444107
86Hematochezia (HP:0002573)1.70051206
87Subacute progressive viral hepatitis (HP:0006572)1.68274531
88Excessive salivation (HP:0003781)1.68257404
89Iris hypopigmentation (HP:0007730)1.68062331
90Breast aplasia (HP:0100783)1.67452827
91Volvulus (HP:0002580)1.67335056
92Short tibia (HP:0005736)1.64919168
93Rimmed vacuoles (HP:0003805)1.64212403
94Abnormality of eosinophils (HP:0001879)1.63537640
95Genital tract atresia (HP:0001827)1.62845935
96Aplasia/Hypoplasia of the breasts (HP:0010311)1.62764924
97Protruding tongue (HP:0010808)1.62615240
98Broad ribs (HP:0000885)1.62384477
99Pelvic girdle muscle weakness (HP:0003749)1.61678435
100Small hand (HP:0200055)1.59756424

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.57928555
2MKNK23.89722235
3WNK33.25948050
4FRK2.93478304
5MARK12.82297918
6MKNK12.64697432
7ERBB32.60128742
8CAMKK22.35630930
9BRD42.31271985
10AKT32.14811477
11ACVR1B1.84904893
12PLK41.77376103
13MAP3K41.69522313
14EPHA41.63265602
15PLK21.61086962
16ZAK1.59456866
17PAK31.55961786
18BRSK21.54807773
19EPHB21.49333008
20CSNK1G31.40985645
21INSRR1.39803250
22CSNK1G21.37858641
23MAPK131.35903970
24ADRBK21.33095627
25MAP4K21.30358658
26SGK21.22927120
27BMPR1B1.22592612
28NTRK21.22220193
29DYRK31.18703046
30PLK31.18186779
31CSNK1G11.17693020
32DYRK1A1.16385559
33PRKCQ1.12861068
34MAP3K61.12841454
35MAP2K71.07470087
36CSNK1A1L1.07096053
37TXK1.02938434
38TGFBR21.02530253
39NTRK31.02303738
40TAOK11.00722829
41MAPK151.00239000
42CAMK1G0.98817432
43SGK10.98640590
44CAMK40.95433950
45TEC0.92824280
46BCR0.92206961
47MAP2K40.91047005
48KSR10.90305896
49BMPR20.89872380
50SIK30.89747120
51TAOK30.89171248
52PRKCE0.85490852
53SGK2230.81844309
54SGK4940.81844309
55GRK60.80966357
56PRKCG0.78099713
57PIK3CG0.77496511
58VRK10.75112593
59BLK0.73972292
60TRIM280.69702890
61CAMK1D0.68823643
62WNK10.67671789
63ERBB20.67120876
64FGR0.66697883
65MUSK0.64734262
66IKBKE0.62314061
67HCK0.61565087
68SGK30.60183026
69FLT30.59188491
70SYK0.58702404
71CAMKK10.55216595
72YES10.53925720
73MARK20.53697136
74MAP4K10.52622383
75PIK3CA0.52109625
76MAP3K30.50282494
77BTK0.49258704
78GRK50.49069801
79NLK0.48387845
80PNCK0.48297207
81STK240.45962444
82IRAK10.45949563
83MATK0.45862125
84CAMK2B0.41567343
85PTK2B0.41552470
86LATS20.41144635
87MAP3K120.41112651
88LYN0.40547921
89PRKCZ0.39392091
90KIT0.37688284
91MAPK100.37326101
92DYRK20.36322155
93PRKG10.35946846
94PKN20.33911668
95UHMK10.33450903
96GSK3A0.33287809
97FES0.33231728
98STK110.32358051
99CSNK1D0.31528857
100MAP3K100.31441470

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043203.56387994
2Nicotine addiction_Homo sapiens_hsa050333.10831195
3Non-homologous end-joining_Homo sapiens_hsa034502.92504539
4Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.76907873
5Regulation of autophagy_Homo sapiens_hsa041402.15056435
6Protein export_Homo sapiens_hsa030602.11184838
7Amphetamine addiction_Homo sapiens_hsa050312.07140151
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.07065176
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05812915
10Long-term potentiation_Homo sapiens_hsa047202.05758028
11Glutamatergic synapse_Homo sapiens_hsa047241.99235036
12Taste transduction_Homo sapiens_hsa047421.83516091
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.71343750
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.67249069
15Long-term depression_Homo sapiens_hsa047301.52263715
16Basal transcription factors_Homo sapiens_hsa030221.48035826
17RNA degradation_Homo sapiens_hsa030181.44169366
18T cell receptor signaling pathway_Homo sapiens_hsa046601.28594496
19Serotonergic synapse_Homo sapiens_hsa047261.25875821
20Caffeine metabolism_Homo sapiens_hsa002321.25008816
21B cell receptor signaling pathway_Homo sapiens_hsa046621.25008638
22Gap junction_Homo sapiens_hsa045401.24763286
23Dopaminergic synapse_Homo sapiens_hsa047281.24540514
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.23658586
25Colorectal cancer_Homo sapiens_hsa052101.19585313
26Fatty acid biosynthesis_Homo sapiens_hsa000611.18986962
27Calcium signaling pathway_Homo sapiens_hsa040201.18224019
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.16364604
29Transcriptional misregulation in cancer_Homo sapiens_hsa052021.16099174
30GABAergic synapse_Homo sapiens_hsa047271.14916364
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.14416420
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.07189604
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06615664
34FoxO signaling pathway_Homo sapiens_hsa040681.06599877
35Cocaine addiction_Homo sapiens_hsa050301.01512711
36p53 signaling pathway_Homo sapiens_hsa041151.01339548
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00965321
38Oocyte meiosis_Homo sapiens_hsa041141.00528794
39Morphine addiction_Homo sapiens_hsa050321.00480462
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.99195862
41Circadian entrainment_Homo sapiens_hsa047130.94955426
42Propanoate metabolism_Homo sapiens_hsa006400.92601532
43Hedgehog signaling pathway_Homo sapiens_hsa043400.85559449
44Renin secretion_Homo sapiens_hsa049240.85461547
45Osteoclast differentiation_Homo sapiens_hsa043800.82046982
46NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81864089
47Circadian rhythm_Homo sapiens_hsa047100.81232060
48Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78303304
49MAPK signaling pathway_Homo sapiens_hsa040100.77567102
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76510391
51Malaria_Homo sapiens_hsa051440.74880190
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.74113826
53Wnt signaling pathway_Homo sapiens_hsa043100.74023582
54Mineral absorption_Homo sapiens_hsa049780.74005831
55Primary immunodeficiency_Homo sapiens_hsa053400.73266422
56Ras signaling pathway_Homo sapiens_hsa040140.72435103
57Fanconi anemia pathway_Homo sapiens_hsa034600.72367813
58Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71836592
59Alcoholism_Homo sapiens_hsa050340.71022142
60Hematopoietic cell lineage_Homo sapiens_hsa046400.68833411
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.68753777
62MicroRNAs in cancer_Homo sapiens_hsa052060.68353369
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.67773548
64Legionellosis_Homo sapiens_hsa051340.67751610
65Hepatitis B_Homo sapiens_hsa051610.66666805
66TGF-beta signaling pathway_Homo sapiens_hsa043500.65153503
67mTOR signaling pathway_Homo sapiens_hsa041500.63950544
68Melanoma_Homo sapiens_hsa052180.63948864
69Cholinergic synapse_Homo sapiens_hsa047250.63471402
70Axon guidance_Homo sapiens_hsa043600.63382911
71Oxytocin signaling pathway_Homo sapiens_hsa049210.63334744
72Butanoate metabolism_Homo sapiens_hsa006500.62522334
73Prolactin signaling pathway_Homo sapiens_hsa049170.62025930
74TNF signaling pathway_Homo sapiens_hsa046680.60648119
75Olfactory transduction_Homo sapiens_hsa047400.59948394
76Non-small cell lung cancer_Homo sapiens_hsa052230.59210593
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.59083318
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.58644282
79Inositol phosphate metabolism_Homo sapiens_hsa005620.58471420
80cAMP signaling pathway_Homo sapiens_hsa040240.57716308
81Choline metabolism in cancer_Homo sapiens_hsa052310.56026558
82Endometrial cancer_Homo sapiens_hsa052130.55707637
83Measles_Homo sapiens_hsa051620.53522304
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52377044
85Tuberculosis_Homo sapiens_hsa051520.51709210
86ErbB signaling pathway_Homo sapiens_hsa040120.48312540
87Cell cycle_Homo sapiens_hsa041100.46267582
88Platelet activation_Homo sapiens_hsa046110.45665212
89Acute myeloid leukemia_Homo sapiens_hsa052210.45604318
90Prostate cancer_Homo sapiens_hsa052150.42515432
91Starch and sucrose metabolism_Homo sapiens_hsa005000.41408652
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41396877
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.41313169
94Ether lipid metabolism_Homo sapiens_hsa005650.40906912
95Nitrogen metabolism_Homo sapiens_hsa009100.40485086
96VEGF signaling pathway_Homo sapiens_hsa043700.40432508
97Chemokine signaling pathway_Homo sapiens_hsa040620.38983380
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37958639
99Pathways in cancer_Homo sapiens_hsa052000.37461993
100Linoleic acid metabolism_Homo sapiens_hsa005910.36367042

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