BNIP3P26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1dosage compensation (GO:0007549)7.24527254
2positive regulation of interleukin-8 biosynthetic process (GO:0045416)5.51919033
3histone mRNA catabolic process (GO:0071044)5.50491628
4regulation of chemokine-mediated signaling pathway (GO:0070099)5.33525150
5negative regulation of histone acetylation (GO:0035067)5.17321042
6negative regulation of receptor-mediated endocytosis (GO:0048261)4.96196150
7neutrophil mediated immunity (GO:0002446)4.74448755
8DNA double-strand break processing (GO:0000729)4.68631812
9negative regulation of histone methylation (GO:0031061)4.52539469
10regulation of gene expression by genetic imprinting (GO:0006349)4.50652360
11regulation of RNA export from nucleus (GO:0046831)4.48717222
12cellular extravasation (GO:0045123)4.40263680
13mitotic sister chromatid cohesion (GO:0007064)4.36275262
14regulation of hippo signaling (GO:0035330)4.28410165
15myeloid leukocyte mediated immunity (GO:0002444)4.17774825
16negative regulation of mast cell activation (GO:0033004)4.12385738
17negative regulation of peptidyl-lysine acetylation (GO:2000757)4.10390253
18regulation of centriole replication (GO:0046599)4.08767949
19regulation of DNA methylation (GO:0044030)4.08164106
20mRNA modification (GO:0016556)4.00129629
21regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.93406385
22microglial cell activation (GO:0001774)3.88466298
23positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.87788740
24replication fork processing (GO:0031297)3.81735270
25apical protein localization (GO:0045176)3.81529691
26positive regulation of histone H3-K4 methylation (GO:0051571)3.80707743
27nuclear pore complex assembly (GO:0051292)3.70603360
28epithelial cilium movement (GO:0003351)3.68397373
29protein K6-linked ubiquitination (GO:0085020)3.60211335
30establishment of nucleus localization (GO:0040023)3.59203580
31cerebral cortex radially oriented cell migration (GO:0021799)3.58395303
32resolution of meiotic recombination intermediates (GO:0000712)3.53019995
33regulation of Rac protein signal transduction (GO:0035020)3.51660891
34response to nitrosative stress (GO:0051409)3.51488152
35histamine secretion (GO:0001821)3.49421388
36myelin assembly (GO:0032288)3.48587616
37protein polyglutamylation (GO:0018095)3.45190799
38disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.43534478
39killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.43534478
40superoxide anion generation (GO:0042554)3.37357003
41tongue development (GO:0043586)3.34962888
42negative regulation of Rho protein signal transduction (GO:0035024)3.34417151
43regulation of telomere maintenance (GO:0032204)3.34132587
44regulation of nucleobase-containing compound transport (GO:0032239)3.32297891
45intraciliary transport (GO:0042073)3.26829178
46positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.24696752
47regulation of histone H3-K9 methylation (GO:0051570)3.22419057
48neural tube formation (GO:0001841)3.20915104
49regulation of interleukin-8 biosynthetic process (GO:0045414)3.19549981
50negative regulation of small GTPase mediated signal transduction (GO:0051058)3.18552195
51negative regulation of exocytosis (GO:0045920)3.17331710
52hepatocyte apoptotic process (GO:0097284)3.16609249
53negative regulation of protein acetylation (GO:1901984)3.13099656
54detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.12135327
55nucleus localization (GO:0051647)3.06506106
56negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.05687830
57histamine transport (GO:0051608)3.03475286
58protein K48-linked deubiquitination (GO:0071108)3.02786373
59regulation of protein glycosylation (GO:0060049)3.02429404
60genetic imprinting (GO:0071514)3.02397043
61cellular response to interferon-alpha (GO:0035457)3.00870545
62regulation of mitochondrial depolarization (GO:0051900)2.99467695
63pore complex assembly (GO:0046931)2.99227661
64inositol phosphate dephosphorylation (GO:0046855)2.98980956
65phosphorylated carbohydrate dephosphorylation (GO:0046838)2.98980956
66negative regulation of fatty acid biosynthetic process (GO:0045717)2.96119574
67positive regulation of cell size (GO:0045793)2.96040583
68artery smooth muscle contraction (GO:0014824)2.92374054
69protein localization to microtubule cytoskeleton (GO:0072698)2.91502800
70negative regulation of organelle assembly (GO:1902116)2.90360771
71RNA destabilization (GO:0050779)2.86596554
72negative regulation of astrocyte differentiation (GO:0048712)2.85187363
73forebrain neuron differentiation (GO:0021879)2.83952352
74DNA damage induced protein phosphorylation (GO:0006975)2.81252215
75modulation of growth of symbiont involved in interaction with host (GO:0044144)2.76453599
76regulation of growth of symbiont in host (GO:0044126)2.76453599
77negative regulation of growth of symbiont in host (GO:0044130)2.76453599
78negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.76453599
79pyrimidine nucleotide catabolic process (GO:0006244)2.76043307
80embryonic foregut morphogenesis (GO:0048617)2.75847813
81ether lipid metabolic process (GO:0046485)2.74711981
82negative regulation of Ras protein signal transduction (GO:0046580)2.73363349
83regulation of histone H3-K4 methylation (GO:0051569)2.73232493
84negative regulation of leukocyte migration (GO:0002686)2.71169734
85anterior/posterior axis specification, embryo (GO:0008595)2.71103245
86base-excision repair, AP site formation (GO:0006285)2.70237259
87regulation of chemokine biosynthetic process (GO:0045073)2.65852401
88sister chromatid cohesion (GO:0007062)2.65169896
89cell migration in hindbrain (GO:0021535)2.63661978
90DNA excision (GO:0044349)2.63432238
91nucleotide-excision repair, DNA damage removal (GO:0000718)2.63432238
92positive regulation of glycoprotein biosynthetic process (GO:0010560)2.62073941
93positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.61673794
94pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.59372042
95protein autoubiquitination (GO:0051865)2.58017358
96cell wall macromolecule catabolic process (GO:0016998)2.57999531
97lymph node development (GO:0048535)2.57943383
98CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.57294672
99T-helper cell differentiation (GO:0042093)2.57294672
100establishment of protein localization to Golgi (GO:0072600)2.56955862

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human5.56548298
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.48989713
3SMAD_19615063_ChIP-ChIP_OVARY_Human4.09236066
4IGF1R_20145208_ChIP-Seq_DFB_Human3.63957116
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.86837248
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.85775712
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.71288274
8TP53_16413492_ChIP-PET_HCT116_Human2.67137720
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.63111805
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.40191875
11ZNF274_21170338_ChIP-Seq_K562_Hela2.32308236
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.28646776
13SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.25961900
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.22877648
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.13219918
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.07377236
17E2F7_22180533_ChIP-Seq_HELA_Human2.04966807
18TAF15_26573619_Chip-Seq_HEK293_Human1.99269049
19P300_19829295_ChIP-Seq_ESCs_Human1.93784649
20CDX2_19796622_ChIP-Seq_MESCs_Mouse1.90845819
21TP63_19390658_ChIP-ChIP_HaCaT_Human1.80066372
22RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.72151173
23EWS_26573619_Chip-Seq_HEK293_Human1.70168015
24ESR1_20079471_ChIP-ChIP_T-47D_Human1.69855673
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67864469
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59717293
27IRF8_22096565_ChIP-ChIP_GC-B_Human1.56780346
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.52439155
29VDR_22108803_ChIP-Seq_LS180_Human1.52431882
30IRF8_21731497_ChIP-ChIP_J774_Mouse1.52218252
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.49641585
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.47889999
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.44842864
34STAT3_23295773_ChIP-Seq_U87_Human1.44673939
35AHR_22903824_ChIP-Seq_MCF-7_Human1.44271233
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43370672
37ER_23166858_ChIP-Seq_MCF-7_Human1.40731790
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40279331
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38772515
40TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.38266986
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.37874162
42PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36822475
43TCF4_23295773_ChIP-Seq_U87_Human1.34627038
44FUS_26573619_Chip-Seq_HEK293_Human1.34292428
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.32192406
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32010648
47CBP_20019798_ChIP-Seq_JUKART_Human1.29482203
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29482203
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29432693
50HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.29089892
51ARNT_22903824_ChIP-Seq_MCF-7_Human1.26232473
52SMAD4_21799915_ChIP-Seq_A2780_Human1.25087692
53ELK1_19687146_ChIP-ChIP_HELA_Human1.24978892
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24902180
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24784114
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22838757
57BRD4_25478319_ChIP-Seq_HGPS_Human1.18795423
58CTNNB1_20460455_ChIP-Seq_HCT116_Human1.17149722
59MYB_26560356_Chip-Seq_TH2_Human1.14816021
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14334123
61POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13616727
62TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13616727
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.13574081
64ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12654081
65NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11583237
66TCF4_22108803_ChIP-Seq_LS180_Human1.08264287
67GATA3_27048872_Chip-Seq_THYMUS_Human1.08053694
68FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07868488
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.06516925
70FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05848582
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05324977
72STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.04409183
73CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04256950
74PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02879340
75FLI1_21867929_ChIP-Seq_TH2_Mouse1.02200279
76CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01322082
77RUNX_20019798_ChIP-Seq_JUKART_Human1.01245357
78PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99619637
79CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.97828182
80NANOG_18555785_Chip-Seq_ESCs_Mouse0.97216712
81GBX2_23144817_ChIP-Seq_PC3_Human0.97150035
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97097359
83IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.96874611
84PRDM14_20953172_ChIP-Seq_ESCs_Human0.95521193
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93434316
86TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93291344
87KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.92686598
88NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92615746
89NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92615746
90ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92200017
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92004675
92KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91334431
93SCL_19346495_ChIP-Seq_HPC-7_Human0.90286533
94SUZ12_27294783_Chip-Seq_NPCs_Mouse0.89617400
95SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89503503
96ETV2_25802403_ChIP-Seq_MESCs_Mouse0.88881074
97GATA1_22025678_ChIP-Seq_K562_Human0.88263329
98FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.87882929
99SMAD4_21741376_ChIP-Seq_HESCs_Human0.87747466
100CJUN_26792858_Chip-Seq_BT549_Human0.87609693

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.10978912
2MP0003787_abnormal_imprinting4.56927309
3MP0008260_abnormal_autophagy4.34598587
4MP0003705_abnormal_hypodermis_morpholog3.02588630
5MP0000427_abnormal_hair_cycle3.00255628
6MP0002095_abnormal_skin_pigmentation2.88860610
7MP0003121_genomic_imprinting2.86136496
8MP0003183_abnormal_peptide_metabolism2.81384015
9MP0006292_abnormal_olfactory_placode2.79562992
10MP0008057_abnormal_DNA_replication2.68848583
11MP0004147_increased_porphyrin_level2.53933935
12MP0010307_abnormal_tumor_latency2.36690083
13MP0003724_increased_susceptibility_to2.20831955
14MP0005409_darkened_coat_color2.08742793
15MP0005174_abnormal_tail_pigmentation2.00607557
16MP0002653_abnormal_ependyma_morphology1.92000252
17MP0003786_premature_aging1.91354741
18MP0000015_abnormal_ear_pigmentation1.84304575
19MP0002168_other_aberrant_phenotype1.75402251
20MP0004484_altered_response_of1.72980234
21MP0002075_abnormal_coat/hair_pigmentati1.72567322
22MP0002089_abnormal_postnatal_growth/wei1.71366283
23MP0003172_abnormal_lysosome_physiology1.66577373
24MP0006276_abnormal_autonomic_nervous1.63243224
25MP0006054_spinal_hemorrhage1.60088127
26MP0002102_abnormal_ear_morphology1.52285631
27MP0010094_abnormal_chromosome_stability1.48085386
28MP0003890_abnormal_embryonic-extraembry1.47774741
29MP0001986_abnormal_taste_sensitivity1.43758527
30MP0003045_fibrosis1.41453501
31MP0003632_abnormal_nervous_system1.39715974
32MP0003191_abnormal_cellular_cholesterol1.34236075
33MP0003567_abnormal_fetal_cardiomyocyte1.32323308
34MP0000778_abnormal_nervous_system1.31591996
35MP0005248_abnormal_Harderian_gland1.31504436
36MP0001186_pigmentation_phenotype1.31365405
37MP0003656_abnormal_erythrocyte_physiolo1.25700896
38MP0009703_decreased_birth_body1.25140487
39MP0000371_diluted_coat_color1.24238220
40MP0004883_abnormal_blood_vessel1.23801338
41MP0001764_abnormal_homeostasis1.22219284
42MP0002751_abnormal_autonomic_nervous1.19165028
43MP0001661_extended_life_span1.17138703
44MP0005408_hypopigmentation1.11693410
45MP0002282_abnormal_trachea_morphology1.11565036
46MP0005075_abnormal_melanosome_morpholog1.11492900
47MP0000613_abnormal_salivary_gland1.05433576
48MP0003755_abnormal_palate_morphology1.03799154
49MP0000462_abnormal_digestive_system1.03364788
50MP0005623_abnormal_meninges_morphology1.03190382
51MP0003943_abnormal_hepatobiliary_system1.01352743
52MP0001800_abnormal_humoral_immune1.01124806
53MP0002405_respiratory_system_inflammati1.01091544
54MP0000467_abnormal_esophagus_morphology0.98361497
55MP0002722_abnormal_immune_system0.97577973
56MP0008961_abnormal_basal_metabolism0.97556800
57MP0002009_preneoplasia0.97552431
58MP0001286_abnormal_eye_development0.95584920
59MP0000689_abnormal_spleen_morphology0.93215729
60MP0008995_early_reproductive_senescence0.92575503
61MP0003385_abnormal_body_wall0.92203673
62MP0002166_altered_tumor_susceptibility0.92043254
63MP0003937_abnormal_limbs/digits/tail_de0.91228817
64MP0005395_other_phenotype0.87265903
65MP0009785_altered_susceptibility_to0.86933786
66MP0000703_abnormal_thymus_morphology0.84301039
67MP0002419_abnormal_innate_immunity0.83360250
68MP0003950_abnormal_plasma_membrane0.81518379
69MP0002420_abnormal_adaptive_immunity0.81511984
70MP0001819_abnormal_immune_cell0.80382061
71MP0001177_atelectasis0.79804778
72MP0002006_tumorigenesis0.79503195
73MP0005379_endocrine/exocrine_gland_phen0.79478500
74MP0000358_abnormal_cell_content/0.79127203
75MP0001929_abnormal_gametogenesis0.78758365
76MP0000716_abnormal_immune_system0.77915648
77MP0002088_abnormal_embryonic_growth/wei0.77309663
78MP0005376_homeostasis/metabolism_phenot0.76970667
79MP0003763_abnormal_thymus_physiology0.76803984
80MP0002398_abnormal_bone_marrow0.75555179
81MP0009765_abnormal_xenobiotic_induced0.74971576
82MP0003698_abnormal_male_reproductive0.74873286
83MP0005083_abnormal_biliary_tract0.72367022
84MP0002127_abnormal_cardiovascular_syste0.71977503
85MP0001835_abnormal_antigen_presentation0.70857558
86MP0002938_white_spotting0.70186010
87MP0002723_abnormal_immune_serum0.69657802
88MP0003984_embryonic_growth_retardation0.68800761
89MP0003935_abnormal_craniofacial_develop0.67928198
90MP0000647_abnormal_sebaceous_gland0.67266628
91MP0003091_abnormal_cell_migration0.66048608
92MP0005451_abnormal_body_composition0.64044260
93MP0003948_abnormal_gas_homeostasis0.63976579
94MP0001243_abnormal_dermal_layer0.63624690
95MP0004264_abnormal_extraembryonic_tissu0.62515419
96MP0003252_abnormal_bile_duct0.60865658
97MP0002396_abnormal_hematopoietic_system0.60466042
98MP0005164_abnormal_response_to0.58955157
99MP0002452_abnormal_antigen_presenting0.58556238
100MP0008873_increased_physiological_sensi0.57687491

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.69804129
2Abnormality of incisor morphology (HP:0011063)4.61248695
3Absent frontal sinuses (HP:0002688)4.57960663
4Severe visual impairment (HP:0001141)4.53919698
5Microglossia (HP:0000171)4.30571028
6Stenosis of the external auditory canal (HP:0000402)4.16054187
7Periodontitis (HP:0000704)3.69361912
8Abnormal number of incisors (HP:0011064)3.68607152
9Papillary thyroid carcinoma (HP:0002895)3.48448945
10Hypochromic microcytic anemia (HP:0004840)3.41523967
11Aqueductal stenosis (HP:0002410)3.41497332
12Abnormality of the incisor (HP:0000676)3.33907993
13Thrombocytosis (HP:0001894)3.30246621
14Eosinophilia (HP:0001880)3.25848957
15Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.25480154
16Aplasia/Hypoplasia of the tongue (HP:0010295)3.07570320
17Abnormality of lateral ventricle (HP:0030047)3.06263993
18Absent rod-and cone-mediated responses on ERG (HP:0007688)2.93822744
19Tented upper lip vermilion (HP:0010804)2.93551492
20Increased number of teeth (HP:0011069)2.90342688
21Abnormality of the frontal sinuses (HP:0002687)2.89955794
22Granulocytopenia (HP:0001913)2.80104093
23Abdominal situs inversus (HP:0003363)2.80036583
24Abnormality of abdominal situs (HP:0011620)2.80036583
25Nuclear cataract (HP:0100018)2.75692596
26Abnormality of the peritoneum (HP:0002585)2.73195752
27Nephronophthisis (HP:0000090)2.56636128
28Genetic anticipation (HP:0003743)2.55956566
29Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.55065849
30Hypoplastic ischia (HP:0003175)2.53175442
31Abnormality of eosinophils (HP:0001879)2.48952942
32IgM deficiency (HP:0002850)2.47076593
33Capillary hemangiomas (HP:0005306)2.46354120
34Abnormality of the ischium (HP:0003174)2.44733347
35Dynein arm defect of respiratory motile cilia (HP:0012255)2.44334307
36Absent/shortened dynein arms (HP:0200106)2.44334307
37T lymphocytopenia (HP:0005403)2.39285570
38Septo-optic dysplasia (HP:0100842)2.35206048
39Abnormality of the prostate (HP:0008775)2.33734347
40Abnormality of T cell number (HP:0011839)2.30661334
41Hyperglycinemia (HP:0002154)2.29312695
42Arterial tortuosity (HP:0005116)2.18074061
43Hypoplasia of the thymus (HP:0000778)2.17474921
44Progressive cerebellar ataxia (HP:0002073)2.14692436
45Abolished electroretinogram (ERG) (HP:0000550)2.12734691
46Large earlobe (HP:0009748)2.11988030
47Abnormality of the renal medulla (HP:0100957)2.11310416
48Tetraparesis (HP:0002273)2.11284621
49Prominent nose (HP:0000448)2.10056001
50Pancreatic fibrosis (HP:0100732)2.09665423
51Widely spaced teeth (HP:0000687)2.06124700
52Abnormality of B cell number (HP:0010975)2.03012497
53Hyperglycinuria (HP:0003108)2.01433360
54Panhypogammaglobulinemia (HP:0003139)1.99651421
55Thyroid carcinoma (HP:0002890)1.99196677
56Recurrent fungal infections (HP:0002841)1.99156402
57Disproportionate short-trunk short stature (HP:0003521)1.97257131
58Pancreatic cysts (HP:0001737)1.97028674
59Asymmetric septal hypertrophy (HP:0001670)1.96531701
60Intellectual disability, progressive (HP:0006887)1.95855226
61Leukocytosis (HP:0001974)1.95444509
62Gonadotropin excess (HP:0000837)1.95164117
63Curly hair (HP:0002212)1.91232237
64Tubulointerstitial nephritis (HP:0001970)1.89987328
65Anteriorly placed anus (HP:0001545)1.89213750
66Thyroiditis (HP:0100646)1.87715409
67Median cleft lip (HP:0000161)1.84924256
68Synophrys (HP:0000664)1.84576998
69Abnormality of the lower motor neuron (HP:0002366)1.83775057
70Abnormality of chromosome stability (HP:0003220)1.83343343
71Abnormal rod and cone electroretinograms (HP:0008323)1.81758191
72Genital tract atresia (HP:0001827)1.81541422
73Hypoplasia of the uterus (HP:0000013)1.80899468
74Severe combined immunodeficiency (HP:0004430)1.79839876
75Amyotrophic lateral sclerosis (HP:0007354)1.78783110
76Gaze-evoked nystagmus (HP:0000640)1.78154561
77Exotropia (HP:0000577)1.77773797
78Metaphyseal dysplasia (HP:0100255)1.77060793
79Truncal obesity (HP:0001956)1.76469548
80Anal atresia (HP:0002023)1.74356891
81Facial diplegia (HP:0001349)1.74042914
82Microcytic anemia (HP:0001935)1.73259583
83Absent septum pellucidum (HP:0001331)1.73115582
84Postaxial foot polydactyly (HP:0001830)1.72042436
85Recurrent bacterial skin infections (HP:0005406)1.70567480
86Infantile muscular hypotonia (HP:0008947)1.70013674
87Vascular tortuosity (HP:0004948)1.69742650
88Progressive inability to walk (HP:0002505)1.66163685
89Chronic mucocutaneous candidiasis (HP:0002728)1.66018663
90Recurrent cutaneous fungal infections (HP:0011370)1.66018663
91Gastrointestinal atresia (HP:0002589)1.65739432
92Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.64781843
93Abnormal delayed hypersensitivity skin test (HP:0002963)1.64215948
94Thyroid-stimulating hormone excess (HP:0002925)1.63949370
95Ulnar deviation of the wrist (HP:0003049)1.63250822
96Intellectual disability, moderate (HP:0002342)1.62110322
97Dyskinesia (HP:0100660)1.61598165
98B lymphocytopenia (HP:0010976)1.61359273
99Recurrent viral infections (HP:0004429)1.60630123
100Agammaglobulinemia (HP:0004432)1.60333395

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K25.70456644
2STK38L4.81875866
3WNK33.95716160
4STK243.85001825
5TNIK3.25531125
6ACVR1B3.13552629
7FRK2.71160967
8NEK12.24188614
9TNK22.12410706
10CDK42.00719522
11NLK1.92791338
12STK31.75126292
13AKT31.71120005
14TAOK31.67403525
15BMPR1B1.62129936
16BRD41.53504389
17IRAK11.42503721
18MAP3K121.42234288
19BLK1.36997080
20SGK21.33285439
21SGK31.31622077
22YES11.31466152
23PAK31.31408467
24IRAK21.25417094
25CHEK21.24870631
26NUAK11.19004286
27PLK21.18847760
28MAP2K41.17945649
29TEC1.16084474
30WNK11.13977285
31CSK1.09106527
32FES1.07900008
33FGR1.03710830
34LIMK10.94784227
35PTK2B0.92813086
36AURKA0.92692900
37DYRK1B0.92564907
38ATR0.91067503
39MATK0.88898667
40MAP4K10.88819471
41JAK30.87639954
42EIF2AK30.85185254
43JAK10.84861081
44IKBKE0.82128672
45FGFR30.81582254
46RIPK40.81105883
47LYN0.80143881
48TGFBR10.80074537
49EPHA40.77861823
50HCK0.76977278
51MAP2K30.74628555
52MKNK20.73891787
53IRAK40.73772820
54TXK0.73633629
55DYRK1A0.70062956
56ERBB40.69253538
57BMPR20.68205615
58MINK10.67073436
59SYK0.66746078
60MAP3K50.61625689
61CDK60.59356780
62LCK0.58248608
63EGFR0.56953048
64ITK0.55477081
65KIT0.55259592
66STK390.54963961
67BMX0.54398152
68TAF10.53573040
69BTK0.53079978
70PTK60.51177233
71PIM10.50307634
72ATM0.47528929
73ERBB20.47497548
74FGFR20.47431378
75NTRK30.46550263
76DYRK30.46195404
77TYRO30.46002002
78TYK20.44151344
79PIK3CG0.42943500
80FGFR10.42510686
81PRKCZ0.41467229
82GRK60.41316647
83STK110.41210992
84SGK2230.40681579
85SGK4940.40681579
86ROCK10.40644656
87PDGFRB0.40240918
88MAP3K110.39361774
89TGFBR20.39148220
90FYN0.38051781
91ERBB30.36757557
92PAK20.36533155
93GRK10.35791879
94NEK60.34593067
95PAK60.33717579
96MST40.33296519
97NEK20.33251960
98STK40.31729088
99MAPK80.30197125
100PRKDC0.30072501

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.59472045
2Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.75153494
3Ubiquitin mediated proteolysis_Homo sapiens_hsa041202.48790982
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.36250965
5Primary immunodeficiency_Homo sapiens_hsa053402.23364465
6Taste transduction_Homo sapiens_hsa047422.15826982
7Basal transcription factors_Homo sapiens_hsa030222.11989643
8Hedgehog signaling pathway_Homo sapiens_hsa043402.00201021
9Thyroid cancer_Homo sapiens_hsa052161.96265732
10Nitrogen metabolism_Homo sapiens_hsa009101.90821270
11Nucleotide excision repair_Homo sapiens_hsa034201.84706506
12Leishmaniasis_Homo sapiens_hsa051401.82274818
13Non-homologous end-joining_Homo sapiens_hsa034501.81286941
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.77400273
15Base excision repair_Homo sapiens_hsa034101.54877033
16Protein export_Homo sapiens_hsa030601.50612083
17Inositol phosphate metabolism_Homo sapiens_hsa005621.40592398
18Phosphatidylinositol signaling system_Homo sapiens_hsa040701.38032522
19Olfactory transduction_Homo sapiens_hsa047401.37522593
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.37414230
21Basal cell carcinoma_Homo sapiens_hsa052171.36627979
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.35065409
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.28523476
24Osteoclast differentiation_Homo sapiens_hsa043801.27002646
25Glycerolipid metabolism_Homo sapiens_hsa005611.24835207
26Dorso-ventral axis formation_Homo sapiens_hsa043201.19204595
27Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.17601692
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.16611463
29Prolactin signaling pathway_Homo sapiens_hsa049171.12594341
30Propanoate metabolism_Homo sapiens_hsa006401.09885585
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.08449206
32Colorectal cancer_Homo sapiens_hsa052101.08314256
33B cell receptor signaling pathway_Homo sapiens_hsa046621.08150632
34Chemokine signaling pathway_Homo sapiens_hsa040621.07543036
35Tuberculosis_Homo sapiens_hsa051521.07058136
36Phototransduction_Homo sapiens_hsa047441.05584915
37Non-small cell lung cancer_Homo sapiens_hsa052231.02581495
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.02005601
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.01832375
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00719654
41RNA degradation_Homo sapiens_hsa030181.00214454
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99976953
43Graft-versus-host disease_Homo sapiens_hsa053320.98052603
44Endometrial cancer_Homo sapiens_hsa052130.97021995
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.96874697
46FoxO signaling pathway_Homo sapiens_hsa040680.96732680
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95728474
48Measles_Homo sapiens_hsa051620.95488914
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.95128087
50MicroRNAs in cancer_Homo sapiens_hsa052060.89090846
51Histidine metabolism_Homo sapiens_hsa003400.88983820
52T cell receptor signaling pathway_Homo sapiens_hsa046600.87939640
53Hepatitis C_Homo sapiens_hsa051600.87935526
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87747572
55NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87318432
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.87010954
57Steroid biosynthesis_Homo sapiens_hsa001000.81025637
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.78155321
59Staphylococcus aureus infection_Homo sapiens_hsa051500.77900100
60Melanogenesis_Homo sapiens_hsa049160.77715540
61Platelet activation_Homo sapiens_hsa046110.75084372
62Autoimmune thyroid disease_Homo sapiens_hsa053200.73561476
63Malaria_Homo sapiens_hsa051440.73543056
64Fatty acid degradation_Homo sapiens_hsa000710.72527342
65mTOR signaling pathway_Homo sapiens_hsa041500.71480988
66Renin-angiotensin system_Homo sapiens_hsa046140.70463678
67Wnt signaling pathway_Homo sapiens_hsa043100.69896647
68Influenza A_Homo sapiens_hsa051640.66674847
69TNF signaling pathway_Homo sapiens_hsa046680.66374250
70Homologous recombination_Homo sapiens_hsa034400.63370182
71Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63294853
72Hippo signaling pathway_Homo sapiens_hsa043900.63289676
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.62670243
74Antigen processing and presentation_Homo sapiens_hsa046120.62559616
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61258637
76Viral carcinogenesis_Homo sapiens_hsa052030.60410083
77ErbB signaling pathway_Homo sapiens_hsa040120.59460860
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58996172
79Hematopoietic cell lineage_Homo sapiens_hsa046400.57806817
80Salivary secretion_Homo sapiens_hsa049700.56152807
81Toxoplasmosis_Homo sapiens_hsa051450.55135546
82Peroxisome_Homo sapiens_hsa041460.54398675
83Acute myeloid leukemia_Homo sapiens_hsa052210.54029631
84Prostate cancer_Homo sapiens_hsa052150.50664455
85Toll-like receptor signaling pathway_Homo sapiens_hsa046200.48848764
86Asthma_Homo sapiens_hsa053100.48043491
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.46240009
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45757777
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42788518
90Cell cycle_Homo sapiens_hsa041100.41526895
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40665427
92Adherens junction_Homo sapiens_hsa045200.40587014
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40452889
94Glioma_Homo sapiens_hsa052140.40267047
95Renal cell carcinoma_Homo sapiens_hsa052110.39870574
96Regulation of autophagy_Homo sapiens_hsa041400.39076820
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38166343
98Phagosome_Homo sapiens_hsa041450.37238390
99Allograft rejection_Homo sapiens_hsa053300.35603961
100TGF-beta signaling pathway_Homo sapiens_hsa043500.35290836

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