BNIP3P27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1kinetochore assembly (GO:0051382)5.29225078
2kinetochore organization (GO:0051383)5.23404468
3cullin deneddylation (GO:0010388)4.85077624
4respiratory chain complex IV assembly (GO:0008535)4.76635413
5mitotic sister chromatid cohesion (GO:0007064)4.51470913
6protein deneddylation (GO:0000338)4.46302541
7DNA ligation (GO:0006266)4.41506466
8cell wall macromolecule catabolic process (GO:0016998)4.27619757
9cytochrome complex assembly (GO:0017004)4.17995896
10metaphase plate congression (GO:0051310)4.00220103
11DNA double-strand break processing (GO:0000729)3.94020235
12DNA replication-dependent nucleosome organization (GO:0034723)3.82117988
13DNA replication-dependent nucleosome assembly (GO:0006335)3.82117988
14centriole replication (GO:0007099)3.77168780
15negative regulation of DNA-dependent DNA replication (GO:2000104)3.60113958
16G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.59745077
17regulation of centriole replication (GO:0046599)3.56344359
18chromatin remodeling at centromere (GO:0031055)3.54563270
19cell wall macromolecule metabolic process (GO:0044036)3.51143147
20nucleoside diphosphate catabolic process (GO:0009134)3.50380611
21regulation of Golgi to plasma membrane protein transport (GO:0042996)3.49946420
22CENP-A containing nucleosome assembly (GO:0034080)3.45407934
23regulation of nuclear cell cycle DNA replication (GO:0033262)3.43322960
24purine nucleobase biosynthetic process (GO:0009113)3.34887602
25DNA strand elongation involved in DNA replication (GO:0006271)3.30111315
26DNA replication-independent nucleosome organization (GO:0034724)3.29915013
27DNA replication-independent nucleosome assembly (GO:0006336)3.29915013
28negative regulation of cell cycle G2/M phase transition (GO:1902750)3.26322408
29deoxyribonucleotide catabolic process (GO:0009264)3.25000586
30regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.22333326
31regulation of mitotic spindle checkpoint (GO:1903504)3.22333326
32DNA strand elongation (GO:0022616)3.17858762
33regulation of female receptivity (GO:0045924)3.15758605
34embryonic retina morphogenesis in camera-type eye (GO:0060059)3.08916056
35recombinational repair (GO:0000725)3.07810330
36regulation of DNA endoreduplication (GO:0032875)3.07115378
37purine deoxyribonucleotide catabolic process (GO:0009155)3.06474008
38regulation of telomere maintenance (GO:0032204)3.05786351
39double-strand break repair via homologous recombination (GO:0000724)3.05246526
40postreplication repair (GO:0006301)3.05035221
41auditory receptor cell differentiation (GO:0042491)3.04647435
42replication fork processing (GO:0031297)3.01988556
43neural tube formation (GO:0001841)2.98688551
44regulation of mitotic metaphase/anaphase transition (GO:0030071)2.98044306
45regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.98044306
46deoxyribose phosphate catabolic process (GO:0046386)2.97183722
47monoubiquitinated protein deubiquitination (GO:0035520)2.96901003
48dopamine transport (GO:0015872)2.96294768
49histone exchange (GO:0043486)2.95656268
50negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.95084585
51regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)2.94219943
52translesion synthesis (GO:0019985)2.93908202
53protein complex biogenesis (GO:0070271)2.93722672
54mitotic metaphase plate congression (GO:0007080)2.91281173
55regulation of telomere maintenance via telomerase (GO:0032210)2.90420409
56regulation of mitotic sister chromatid separation (GO:0010965)2.89771937
57regulation of mitotic sister chromatid segregation (GO:0033047)2.89771937
58regulation of sister chromatid segregation (GO:0033045)2.89771937
59mitochondrial respiratory chain complex assembly (GO:0033108)2.87609318
60positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.87310556
61positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.87310556
62positive regulation of mitotic sister chromatid separation (GO:1901970)2.87310556
63negative regulation of mitotic sister chromatid separation (GO:2000816)2.85864482
64negative regulation of sister chromatid segregation (GO:0033046)2.85864482
65negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.85864482
66negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.85864482
67negative regulation of mitotic sister chromatid segregation (GO:0033048)2.85864482
68V(D)J recombination (GO:0033151)2.83870542
69regulation of DNA-templated transcription, initiation (GO:2000142)2.82535360
70resolution of meiotic recombination intermediates (GO:0000712)2.81634761
71non-recombinational repair (GO:0000726)2.81424124
72double-strand break repair via nonhomologous end joining (GO:0006303)2.81424124
73pteridine-containing compound biosynthetic process (GO:0042559)2.80606580
74histone H3-K9 methylation (GO:0051567)2.78412566
75positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.78110899
76mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.78110899
77nitric oxide mediated signal transduction (GO:0007263)2.76743376
78establishment of chromosome localization (GO:0051303)2.76664497
79positive regulation of chromosome segregation (GO:0051984)2.75006056
80mRNA cleavage (GO:0006379)2.73664731
81detection of light stimulus involved in sensory perception (GO:0050962)2.72234122
82detection of light stimulus involved in visual perception (GO:0050908)2.72234122
83maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.72154600
84negative regulation of chromosome segregation (GO:0051985)2.72148220
85mitotic recombination (GO:0006312)2.71494171
86purine deoxyribonucleotide metabolic process (GO:0009151)2.71374028
87replicative senescence (GO:0090399)2.69563397
88DNA replication checkpoint (GO:0000076)2.68725712
89nucleobase biosynthetic process (GO:0046112)2.68471609
90kidney morphogenesis (GO:0060993)2.67156704
91mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.66788603
92mitochondrial respiratory chain complex I assembly (GO:0032981)2.66788603
93NADH dehydrogenase complex assembly (GO:0010257)2.66788603
94embryonic digestive tract development (GO:0048566)2.66707485
95telomere maintenance via recombination (GO:0000722)2.66298523
96C-terminal protein amino acid modification (GO:0018410)2.65754446
97adenosine metabolic process (GO:0046085)2.59175451
98mitotic G2/M transition checkpoint (GO:0044818)2.58811059
99mitotic spindle checkpoint (GO:0071174)2.57598554
100female mating behavior (GO:0060180)2.55439123

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.64028194
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.92416176
3FUS_26573619_Chip-Seq_HEK293_Human2.92846631
4POU3F2_20337985_ChIP-ChIP_501MEL_Human2.74257081
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.66492015
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.66308768
7TAF15_26573619_Chip-Seq_HEK293_Human2.55047440
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.51703797
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.36280968
10ZNF274_21170338_ChIP-Seq_K562_Hela2.34032841
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.27605859
12EWS_26573619_Chip-Seq_HEK293_Human2.25604948
13RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.25140202
14VDR_22108803_ChIP-Seq_LS180_Human2.24476709
15GBX2_23144817_ChIP-Seq_PC3_Human2.19415254
16ELK1_19687146_ChIP-ChIP_HELA_Human2.14593234
17P300_19829295_ChIP-Seq_ESCs_Human2.06278570
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00351628
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.94064894
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93772162
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80091479
22IRF1_19129219_ChIP-ChIP_H3396_Human1.78552004
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75894928
24TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67021268
25POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.67021268
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.65776518
27MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.60674875
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53432849
29SMAD4_21799915_ChIP-Seq_A2780_Human1.52944808
30PIAS1_25552417_ChIP-Seq_VCAP_Human1.52672843
31EST1_17652178_ChIP-ChIP_JURKAT_Human1.50013030
32KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.49365403
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47058098
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.46098321
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.45261600
36IGF1R_20145208_ChIP-Seq_DFB_Human1.45100325
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.44572136
38NANOG_18555785_Chip-Seq_ESCs_Mouse1.43630991
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42642299
40STAT3_23295773_ChIP-Seq_U87_Human1.42409993
41TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40694484
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37395836
43TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36414194
44FOXM1_23109430_ChIP-Seq_U2OS_Human1.35687077
45VDR_23849224_ChIP-Seq_CD4+_Human1.34925347
46GABP_17652178_ChIP-ChIP_JURKAT_Human1.33685336
47RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.33194744
48EZH2_27294783_Chip-Seq_NPCs_Mouse1.32560003
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31499677
50RUNX2_22187159_ChIP-Seq_PCA_Human1.30236509
51ER_23166858_ChIP-Seq_MCF-7_Human1.30053585
52TCF4_23295773_ChIP-Seq_U87_Human1.29347222
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.28386293
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27708238
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27049522
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26879666
57FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.26567704
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26141939
59EZH2_22144423_ChIP-Seq_EOC_Human1.25262041
60MYC_18940864_ChIP-ChIP_HL60_Human1.25192362
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.23534618
62TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.22879453
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22347759
64CBP_20019798_ChIP-Seq_JUKART_Human1.22279912
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22279912
66E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.22196276
67FOXM1_26456572_ChIP-Seq_MCF-7_Human1.21293240
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.19896048
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19836980
70KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19321489
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17062526
72YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16639232
73E2F1_18555785_Chip-Seq_ESCs_Mouse1.16036607
74TCF4_22108803_ChIP-Seq_LS180_Human1.14633399
75FOXP3_21729870_ChIP-Seq_TREG_Human1.12987899
76SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12815705
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12426760
78DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.11782997
79P53_22387025_ChIP-Seq_ESCs_Mouse1.10200355
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08248541
81NANOG_19829295_ChIP-Seq_ESCs_Human1.07530719
82SOX2_19829295_ChIP-Seq_ESCs_Human1.07530719
83P300_18555785_Chip-Seq_ESCs_Mouse1.06967176
84FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06751932
85FOXA1_25329375_ChIP-Seq_VCAP_Human1.06751932
86FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.06453873
87CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04825210
88CMYC_18555785_Chip-Seq_ESCs_Mouse1.04236404
89AR_21909140_ChIP-Seq_LNCAP_Human1.03794778
90NFE2_27457419_Chip-Seq_LIVER_Mouse1.03674450
91CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03658511
92FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02980988
93SOX2_18555785_Chip-Seq_ESCs_Mouse1.02339523
94AR_25329375_ChIP-Seq_VCAP_Human1.01654677
95HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01601229
96SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00675670
97OCT4_18555785_Chip-Seq_ESCs_Mouse1.00644854
98TP53_22573176_ChIP-Seq_HFKS_Human1.00567461
99PRDM14_20953172_ChIP-Seq_ESCs_Human0.99025821
100TAL1_26923725_Chip-Seq_HPCs_Mouse0.98837019

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting4.68394624
2MP0010094_abnormal_chromosome_stability4.15113104
3MP0009780_abnormal_chondrocyte_physiolo3.93802074
4MP0000569_abnormal_digit_pigmentation3.83132552
5MP0003121_genomic_imprinting3.72750016
6MP0008877_abnormal_DNA_methylation3.65463068
7MP0003122_maternal_imprinting3.39958730
8MP0004885_abnormal_endolymph2.61253941
9MP0006072_abnormal_retinal_apoptosis2.54992717
10MP0008057_abnormal_DNA_replication2.54502770
11MP0008058_abnormal_DNA_repair2.39496562
12MP0003136_yellow_coat_color2.27076063
13MP0002837_dystrophic_cardiac_calcinosis2.25136472
14MP0000372_irregular_coat_pigmentation2.21505063
15MP0002909_abnormal_adrenal_gland1.98472536
16MP0009697_abnormal_copulation1.97563886
17MP0003111_abnormal_nucleus_morphology1.95977355
18MP0002876_abnormal_thyroid_physiology1.74522381
19MP0005451_abnormal_body_composition1.66628191
20MP0008789_abnormal_olfactory_epithelium1.61407451
21MP0005645_abnormal_hypothalamus_physiol1.58473160
22MP0010352_gastrointestinal_tract_polyps1.57730027
23MP0005379_endocrine/exocrine_gland_phen1.56383248
24MP0001529_abnormal_vocalization1.54753313
25MP0005551_abnormal_eye_electrophysiolog1.50821192
26MP0002163_abnormal_gland_morphology1.49549989
27MP0001968_abnormal_touch/_nociception1.49204738
28MP0010307_abnormal_tumor_latency1.48953594
29MP0001485_abnormal_pinna_reflex1.47706454
30MP0002693_abnormal_pancreas_physiology1.47493771
31MP0002751_abnormal_autonomic_nervous1.45942096
32MP0002938_white_spotting1.45201078
33MP0005253_abnormal_eye_physiology1.38947128
34MP0002009_preneoplasia1.38146764
35MP0003567_abnormal_fetal_cardiomyocyte1.36227581
36MP0002736_abnormal_nociception_after1.36183650
37MP0009046_muscle_twitch1.32708844
38MP0001486_abnormal_startle_reflex1.32065190
39MP0003077_abnormal_cell_cycle1.29249849
40MP0006035_abnormal_mitochondrial_morpho1.28387169
41MP0001764_abnormal_homeostasis1.26597003
42MP0006292_abnormal_olfactory_placode1.25371287
43MP0006276_abnormal_autonomic_nervous1.19690193
44MP0000631_abnormal_neuroendocrine_gland1.12709920
45MP0003718_maternal_effect1.12259223
46MP0005171_absent_coat_pigmentation1.10765749
47MP0003195_calcinosis1.10072178
48MP0005266_abnormal_metabolism1.08260162
49MP0003943_abnormal_hepatobiliary_system1.04207571
50MP0009703_decreased_birth_body1.03830111
51MP0001905_abnormal_dopamine_level1.01807834
52MP0008775_abnormal_heart_ventricle1.00675297
53MP0000427_abnormal_hair_cycle1.00564129
54MP0001293_anophthalmia0.99902452
55MP0006036_abnormal_mitochondrial_physio0.99371437
56MP0004147_increased_porphyrin_level0.97922087
57MP0005220_abnormal_exocrine_pancreas0.97486401
58MP0002095_abnormal_skin_pigmentation0.96087819
59MP0008872_abnormal_physiological_respon0.95522178
60MP0005394_taste/olfaction_phenotype0.93070396
61MP0005499_abnormal_olfactory_system0.93070396
62MP0002735_abnormal_chemical_nociception0.92352017
63MP0004133_heterotaxia0.92268319
64MP0002638_abnormal_pupillary_reflex0.91052831
65MP0001963_abnormal_hearing_physiology0.90789052
66MP0005174_abnormal_tail_pigmentation0.90224492
67MP0002090_abnormal_vision0.89722444
68MP0004142_abnormal_muscle_tone0.89283647
69MP0001501_abnormal_sleep_pattern0.88752526
70MP0004957_abnormal_blastocyst_morpholog0.87427902
71MP0002928_abnormal_bile_duct0.87318748
72MP0005646_abnormal_pituitary_gland0.86588873
73MP0008932_abnormal_embryonic_tissue0.85468687
74MP0004215_abnormal_myocardial_fiber0.85234397
75MP0001944_abnormal_pancreas_morphology0.84736974
76MP0008961_abnormal_basal_metabolism0.84586731
77MP0004043_abnormal_pH_regulation0.84260136
78MP0003890_abnormal_embryonic-extraembry0.83241090
79MP0008007_abnormal_cellular_replicative0.82208333
80MP0000358_abnormal_cell_content/0.81632678
81MP0002557_abnormal_social/conspecific_i0.80587220
82MP0001299_abnormal_eye_distance/0.79475785
83MP0010386_abnormal_urinary_bladder0.78830663
84MP0003123_paternal_imprinting0.76055503
85MP0002233_abnormal_nose_morphology0.75459431
86MP0000639_abnormal_adrenal_gland0.75274850
87MP0002177_abnormal_outer_ear0.73316750
88MP0005391_vision/eye_phenotype0.70743656
89MP0005395_other_phenotype0.69498368
90MP0002734_abnormal_mechanical_nocicepti0.68742873
91MP0009672_abnormal_birth_weight0.67928107
92MP0001177_atelectasis0.67593253
93MP0002572_abnormal_emotion/affect_behav0.67416643
94MP0002067_abnormal_sensory_capabilities0.66808456
95MP0003941_abnormal_skin_development0.66788863
96MP0004742_abnormal_vestibular_system0.62925726
97MP0005376_homeostasis/metabolism_phenot0.62439383
98MP0002396_abnormal_hematopoietic_system0.61253820
99MP0009745_abnormal_behavioral_response0.60243021
100MP0000230_abnormal_systemic_arterial0.59770058

Predicted human phenotypes

RankGene SetZ-score
1Tubulointerstitial nephritis (HP:0001970)4.27679480
2Abnormality of endocrine pancreas physiology (HP:0012093)4.13268823
3Abnormality of the pancreatic islet cells (HP:0006476)4.13268823
4Chromsome breakage (HP:0040012)3.97753545
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.94475063
6Volvulus (HP:0002580)3.44069798
7Ketoacidosis (HP:0001993)3.31667093
8Abnormality of chromosome stability (HP:0003220)3.23639322
9Abnormality of the labia minora (HP:0012880)3.10395622
10Severe combined immunodeficiency (HP:0004430)2.94035301
11Late onset (HP:0003584)2.84795922
12Abnormality of the antihelix (HP:0009738)2.83642671
13Intestinal atresia (HP:0011100)2.81085236
14Molar tooth sign on MRI (HP:0002419)2.77530021
15Abnormality of midbrain morphology (HP:0002418)2.77530021
16True hermaphroditism (HP:0010459)2.73706154
17Aplasia/Hypoplasia of the uvula (HP:0010293)2.70889755
18Gastrointestinal atresia (HP:0002589)2.63238922
19Acute lymphatic leukemia (HP:0006721)2.56330584
20Colon cancer (HP:0003003)2.53110895
21B lymphocytopenia (HP:0010976)2.50628611
22Nephronophthisis (HP:0000090)2.47807176
23Thyroiditis (HP:0100646)2.47288790
24Meckel diverticulum (HP:0002245)2.47037249
25Congenital sensorineural hearing impairment (HP:0008527)2.42289693
26Neurodegeneration (HP:0002180)2.40553576
27Congenital stationary night blindness (HP:0007642)2.40009721
28Hypoplastic pelvis (HP:0008839)2.39686450
29Aplasia/Hypoplasia of the tibia (HP:0005772)2.39566751
30Combined immunodeficiency (HP:0005387)2.37591159
31Pancreatic fibrosis (HP:0100732)2.37376299
32Abnormality of the renal medulla (HP:0100957)2.36922417
33Severe global developmental delay (HP:0011344)2.33878561
34Aplasia/Hypoplasia of the tongue (HP:0010295)2.31903053
35Aplasia/Hypoplasia of the sternum (HP:0006714)2.31384434
36Abnormality of the preputium (HP:0100587)2.30665885
37Abnormality of the ileum (HP:0001549)2.29728645
38Pancreatic cysts (HP:0001737)2.29423186
39Widely spaced teeth (HP:0000687)2.29074355
40Pendular nystagmus (HP:0012043)2.28073124
41Esophageal atresia (HP:0002032)2.25816138
42Clubbing of toes (HP:0100760)2.25769531
43Neoplasm of the adrenal cortex (HP:0100641)2.25150126
44Abnormal hair whorl (HP:0010721)2.21104856
45Bony spicule pigmentary retinopathy (HP:0007737)2.18645900
46Abnormality of B cell number (HP:0010975)2.17744971
47Sloping forehead (HP:0000340)2.16017885
48Intellectual disability, progressive (HP:0006887)2.12412501
49Ketosis (HP:0001946)2.10851345
50Hypoproteinemia (HP:0003075)2.08433225
51Rectal fistula (HP:0100590)2.07911402
52Rectovaginal fistula (HP:0000143)2.07911402
53Short tibia (HP:0005736)2.03175212
54Brushfield spots (HP:0001088)2.02719754
55Glioma (HP:0009733)1.99174537
56Fair hair (HP:0002286)1.98288077
57Abnormal rod and cone electroretinograms (HP:0008323)1.98226494
58Aqueductal stenosis (HP:0002410)1.97958055
59Hyperglycinemia (HP:0002154)1.96948477
60Central scotoma (HP:0000603)1.95523181
61Rhabdomyosarcoma (HP:0002859)1.94055873
62Abnormality of the duodenum (HP:0002246)1.93733972
63Medial flaring of the eyebrow (HP:0010747)1.93291063
64Delayed CNS myelination (HP:0002188)1.92428310
65Respiratory difficulties (HP:0002880)1.92017033
66Thyroid-stimulating hormone excess (HP:0002925)1.91649614
67Panhypogammaglobulinemia (HP:0003139)1.91158527
68Hemiparesis (HP:0001269)1.90933377
69Septo-optic dysplasia (HP:0100842)1.90723239
70Preaxial hand polydactyly (HP:0001177)1.88878404
71Triphalangeal thumb (HP:0001199)1.86828142
72Narrow forehead (HP:0000341)1.85556314
73Attenuation of retinal blood vessels (HP:0007843)1.85259310
74Cutis marmorata (HP:0000965)1.84638432
75Metaphyseal dysplasia (HP:0100255)1.84579971
76Intestinal fistula (HP:0100819)1.84036339
77Gaze-evoked nystagmus (HP:0000640)1.82534304
78Episodic fever (HP:0001954)1.81865423
79Chronic hepatic failure (HP:0100626)1.81495018
80Clitoromegaly (HP:0000057)1.81032923
81Epiphyseal stippling (HP:0010655)1.80160899
82Abnormality of the renal cortex (HP:0011035)1.79485560
83Agitation (HP:0000713)1.79016407
84Duodenal stenosis (HP:0100867)1.77992933
85Small intestinal stenosis (HP:0012848)1.77992933
86Oligodactyly (hands) (HP:0001180)1.77100638
87Hypoplastic labia majora (HP:0000059)1.76683511
88Postaxial foot polydactyly (HP:0001830)1.76063358
89Abnormal lung lobation (HP:0002101)1.75512736
90Tubulointerstitial abnormality (HP:0001969)1.75251430
91Drooling (HP:0002307)1.74880747
92Inability to walk (HP:0002540)1.73555727
93Abnormality of the carotid arteries (HP:0005344)1.72941610
94Microglossia (HP:0000171)1.71807985
95Generalized hypopigmentation of hair (HP:0011358)1.69364314
96Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.68823821
97Genital tract atresia (HP:0001827)1.68275397
98Poor head control (HP:0002421)1.67246315
99Horizontal nystagmus (HP:0000666)1.67073788
100Pancreatic islet-cell hyperplasia (HP:0004510)1.67006951

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.43175041
2ZAK3.25753709
3MAP4K23.16629014
4MKNK12.58954086
5PNCK2.50386348
6MKNK22.44747117
7BMPR1B2.43791114
8MAPK132.25992108
9PLK42.13695890
10CDC72.13692209
11NUAK11.99488384
12WEE11.77482921
13WNK31.74590777
14AKT31.72280830
15TSSK61.70428249
16TTK1.66591936
17BRD41.64109994
18PLK31.61871326
19TAOK31.61328924
20TRIM281.60717496
21EIF2AK31.58619286
22FLT31.57129435
23PIK3CA1.55654117
24MAP3K91.52199071
25CDK81.51251044
26MAP3K41.45841657
27BUB11.40928054
28CLK11.38819669
29FGFR21.32747710
30BRSK21.31894812
31MAP3K101.29923256
32ERBB31.29772887
33NEK11.25638359
34FGFR31.25616888
35ACVR1B1.21936238
36MAP2K71.11522579
37YES11.09791759
38TNIK1.06297607
39PLK11.05443131
40NLK1.05399383
41MAPKAPK31.04448349
42TGFBR11.02271165
43MAPKAPK51.01354915
44MAP3K21.01265526
45TRPM71.01149670
46CSNK1G10.93187114
47ADRBK20.93130577
48KIT0.92797223
49TAF10.91501830
50IRAK10.89604907
51CDK30.89483257
52PAK30.88328382
53PINK10.88132437
54FGFR10.88069093
55STK30.86395988
56STK38L0.83050058
57ATR0.81807073
58PKN10.80996776
59EIF2AK20.79093163
60CHEK20.74551229
61ATM0.74300984
62MST40.66042933
63DYRK30.62686243
64EGFR0.58742119
65EPHA30.56986606
66DAPK20.56865422
67EEF2K0.56752421
68CCNB10.55905666
69STK390.55680680
70TEC0.55645427
71AURKB0.54490714
72PLK20.54455940
73PRKCE0.53193813
74PASK0.50096342
75CSNK1G30.49835662
76PRKDC0.48437430
77OXSR10.46628694
78CDK70.46447258
79CDK10.42562511
80CSNK1E0.41751998
81ERBB20.40693160
82CSNK2A20.39641123
83MINK10.39455849
84GRK70.37776000
85CAMK2A0.36394799
86RPS6KA40.36353273
87CSNK2A10.35602385
88CSNK1A10.35451952
89GRK10.35364506
90PRKCG0.34553276
91CSNK1D0.34137282
92NEK20.32099844
93DYRK20.31911782
94BCR0.31364866
95CSNK1G20.30878761
96MARK30.30210459
97TAOK10.29957228
98PRKG10.28292254
99STK110.27403239
100PRKACB0.25814493

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.16645479
2Fanconi anemia pathway_Homo sapiens_hsa034603.06380065
3Homologous recombination_Homo sapiens_hsa034402.96879418
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.93308884
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.89905446
6Non-homologous end-joining_Homo sapiens_hsa034502.83986000
7Folate biosynthesis_Homo sapiens_hsa007902.69943351
8Mismatch repair_Homo sapiens_hsa034302.68822586
9DNA replication_Homo sapiens_hsa030302.59080581
10Caffeine metabolism_Homo sapiens_hsa002322.43087299
11Butanoate metabolism_Homo sapiens_hsa006502.40891371
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.40794601
13Protein export_Homo sapiens_hsa030602.25766488
14Base excision repair_Homo sapiens_hsa034102.23804204
15Lysine degradation_Homo sapiens_hsa003102.11983701
16Propanoate metabolism_Homo sapiens_hsa006402.02688569
17SNARE interactions in vesicular transport_Homo sapiens_hsa041301.96860352
18Steroid biosynthesis_Homo sapiens_hsa001001.87181123
19RNA polymerase_Homo sapiens_hsa030201.82468462
20RNA degradation_Homo sapiens_hsa030181.80131941
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.80027194
22One carbon pool by folate_Homo sapiens_hsa006701.78871830
23Cell cycle_Homo sapiens_hsa041101.74152887
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.63714380
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.50783471
26Oocyte meiosis_Homo sapiens_hsa041141.46229339
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44335101
28Nicotine addiction_Homo sapiens_hsa050331.44232948
29Purine metabolism_Homo sapiens_hsa002301.43912568
30Tryptophan metabolism_Homo sapiens_hsa003801.43409214
31Fatty acid elongation_Homo sapiens_hsa000621.42331229
32Basal transcription factors_Homo sapiens_hsa030221.41730750
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.41668606
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.33115145
35Phototransduction_Homo sapiens_hsa047441.31617305
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.26634292
37beta-Alanine metabolism_Homo sapiens_hsa004101.14568691
38Spliceosome_Homo sapiens_hsa030401.08688542
39Selenocompound metabolism_Homo sapiens_hsa004501.08632771
40Taste transduction_Homo sapiens_hsa047421.06643213
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99283737
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.99016774
43RNA transport_Homo sapiens_hsa030130.97120854
44mRNA surveillance pathway_Homo sapiens_hsa030150.96562986
45Nucleotide excision repair_Homo sapiens_hsa034200.92062733
46p53 signaling pathway_Homo sapiens_hsa041150.89354370
47Primary immunodeficiency_Homo sapiens_hsa053400.87310076
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85217443
49Pentose and glucuronate interconversions_Homo sapiens_hsa000400.83849579
50Ether lipid metabolism_Homo sapiens_hsa005650.83616208
51Pyrimidine metabolism_Homo sapiens_hsa002400.82354072
52Salivary secretion_Homo sapiens_hsa049700.81012926
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.77544965
54Circadian rhythm_Homo sapiens_hsa047100.74647422
55Glycosaminoglycan degradation_Homo sapiens_hsa005310.73740584
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64911752
57N-Glycan biosynthesis_Homo sapiens_hsa005100.63557372
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62733181
59GABAergic synapse_Homo sapiens_hsa047270.60894754
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59789034
61Serotonergic synapse_Homo sapiens_hsa047260.58833347
62Metabolic pathways_Homo sapiens_hsa011000.58325080
63Regulation of autophagy_Homo sapiens_hsa041400.58096605
64Retinol metabolism_Homo sapiens_hsa008300.57545265
65Peroxisome_Homo sapiens_hsa041460.56750069
66Renin secretion_Homo sapiens_hsa049240.54814422
67Oxidative phosphorylation_Homo sapiens_hsa001900.54711072
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53939942
69Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53539565
70Nitrogen metabolism_Homo sapiens_hsa009100.53376618
71Morphine addiction_Homo sapiens_hsa050320.53264631
72Parkinsons disease_Homo sapiens_hsa050120.52345325
73Chemical carcinogenesis_Homo sapiens_hsa052040.51652206
74Fatty acid metabolism_Homo sapiens_hsa012120.51448460
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49143122
76Proteasome_Homo sapiens_hsa030500.48937645
77Circadian entrainment_Homo sapiens_hsa047130.48777253
78Insulin secretion_Homo sapiens_hsa049110.48458772
79Linoleic acid metabolism_Homo sapiens_hsa005910.48004381
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43860153
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43584148
82Fatty acid biosynthesis_Homo sapiens_hsa000610.41718585
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40975652
84Amphetamine addiction_Homo sapiens_hsa050310.39815964
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.37491446
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.35666284
87Arginine and proline metabolism_Homo sapiens_hsa003300.34121429
88Vitamin B6 metabolism_Homo sapiens_hsa007500.33622353
89Fatty acid degradation_Homo sapiens_hsa000710.33328168
90Dopaminergic synapse_Homo sapiens_hsa047280.32453068
91Arachidonic acid metabolism_Homo sapiens_hsa005900.30881617
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.29536263
93Long-term depression_Homo sapiens_hsa047300.29079516
94Huntingtons disease_Homo sapiens_hsa050160.28674466
95cAMP signaling pathway_Homo sapiens_hsa040240.27755533
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.27699425
97Calcium signaling pathway_Homo sapiens_hsa040200.27353226
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22329565
99Hippo signaling pathway_Homo sapiens_hsa043900.20960511
100Glutathione metabolism_Homo sapiens_hsa004800.20354380

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