ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	leukotriene biosynthetic process (GO:0019370)	5.73477080
2	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	5.72622921
3	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	5.72622921
4	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	5.71258775
5	cardiac left ventricle morphogenesis (GO:0003214)	5.67393434
6	cysteine metabolic process (GO:0006534)	5.48847900
7	resolution of meiotic recombination intermediates (GO:0000712)	5.31606915
8	positive regulation of catecholamine secretion (GO:0033605)	5.28005768
9	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	5.27253665
10	response to nitrosative stress (GO:0051409)	5.10362821
11	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	4.79683015
12	negative regulation of membrane potential (GO:0045837)	4.61833176
13	notochord development (GO:0030903)	4.59631029
14	fucose catabolic process (GO:0019317)	4.55303016
15	L-fucose metabolic process (GO:0042354)	4.55303016
16	L-fucose catabolic process (GO:0042355)	4.55303016
17	protein-chromophore linkage (GO:0018298)	4.47815339
18	sphingosine metabolic process (GO:0006670)	4.45348021
19	somite rostral/caudal axis specification (GO:0032525)	4.19620102
20	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:006052	4.11960115
21	paraxial mesoderm development (GO:0048339)	4.06787968
22	regulation of meiosis I (GO:0060631)	4.02645236
23	diol metabolic process (GO:0034311)	3.90298325
24	regulation of protein glycosylation (GO:0060049)	3.89198597
25	negative regulation of neurological system process (GO:0031645)	3.86721074
26	meiotic chromosome segregation (GO:0045132)	3.79012601
27	regulation of helicase activity (GO:0051095)	3.78102050
28	leukotriene metabolic process (GO:0006691)	3.69436458
29	activated T cell proliferation (GO:0050798)	3.68655150
30	kynurenine metabolic process (GO:0070189)	3.67748007
31	glutathione metabolic process (GO:0006749)	3.65509843
32	preassembly of GPI anchor in ER membrane (GO:0016254)	3.62412131
33	regulation of establishment of cell polarity (GO:2000114)	3.60709996
34	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.55865911
35	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.55865911
36	positive regulation of circadian rhythm (GO:0042753)	3.54962976
37	sphingoid metabolic process (GO:0046519)	3.54936992
38	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	3.54716342
39	indolalkylamine metabolic process (GO:0006586)	3.54682051
40	platelet dense granule organization (GO:0060155)	3.52526934
41	embryonic axis specification (GO:0000578)	3.52333204
42	heme transport (GO:0015886)	3.49683975
43	DNA methylation involved in gamete generation (GO:0043046)	3.47902471
44	regulation of establishment or maintenance of cell polarity (GO:0032878)	3.42480063
45	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	3.40798340
46	pseudouridine synthesis (GO:0001522)	3.39700603
47	protein targeting to vacuole (GO:0006623)	3.39082397
48	protein targeting to lysosome (GO:0006622)	3.39082397
49	establishment of protein localization to vacuole (GO:0072666)	3.39082397
50	positive regulation of fatty acid oxidation (GO:0046321)	3.35962979
51	replication fork processing (GO:0031297)	3.34574342
52	cell migration involved in gastrulation (GO:0042074)	3.33595378
53	sensory perception of taste (GO:0050909)	3.32498495
54	lipopolysaccharide biosynthetic process (GO:0009103)	3.31660029
55	icosanoid biosynthetic process (GO:0046456)	3.25834705
56	fatty acid derivative biosynthetic process (GO:1901570)	3.25834705
57	pantothenate metabolic process (GO:0015939)	3.23073282
58	neural tube formation (GO:0001841)	3.21641077
59	transmission of nerve impulse (GO:0019226)	3.21238960
60	regulation of pigment cell differentiation (GO:0050932)	3.17404093
61	acrosome assembly (GO:0001675)	3.14051930
62	regulation of sarcomere organization (GO:0060297)	3.10331616
63	positive regulation of smooth muscle contraction (GO:0045987)	3.08930787
64	nuclear pore organization (GO:0006999)	3.05127721
65	acrosome reaction (GO:0007340)	3.02029489
66	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	2.99518702
67	negative regulation of cAMP-mediated signaling (GO:0043951)	2.99168997
68	tRNA processing (GO:0008033)	2.97428980
69	regulation of dopamine secretion (GO:0014059)	2.96914540
70	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.95773184
71	mismatch repair (GO:0006298)	2.90220413
72	indole-containing compound catabolic process (GO:0042436)	2.88639490
73	indolalkylamine catabolic process (GO:0046218)	2.88639490
74	tryptophan catabolic process (GO:0006569)	2.88639490
75	regulation of telomere maintenance via telomerase (GO:0032210)	2.87644717
76	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.85286735
77	inositol phosphate dephosphorylation (GO:0046855)	2.85286735
78	DNA deamination (GO:0045006)	2.85266583
79	otic vesicle formation (GO:0030916)	2.85138476
80	protein ADP-ribosylation (GO:0006471)	2.83247110
81	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.81704422
82	DNA damage induced protein phosphorylation (GO:0006975)	2.81472538
83	regulation of DNA damage checkpoint (GO:2000001)	2.81148195
84	regulation of telomere maintenance (GO:0032204)	2.81112668
85	genitalia morphogenesis (GO:0035112)	2.80723038
86	nuclear pore complex assembly (GO:0051292)	2.80656439
87	peptide catabolic process (GO:0043171)	2.80608969
88	regulation of feeding behavior (GO:0060259)	2.76361613
89	positive regulation of cytokinesis (GO:0032467)	2.74070433
90	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.73690013
91	unsaturated fatty acid biosynthetic process (GO:0006636)	2.73378439
92	respiratory chain complex IV assembly (GO:0008535)	2.72800601
93	translational termination (GO:0006415)	2.71954118
94	glycerol metabolic process (GO:0006071)	2.71730480
95	serine family amino acid biosynthetic process (GO:0009070)	2.69904301
96	organ induction (GO:0001759)	2.69845397
97	signal peptide processing (GO:0006465)	2.69681231
98	aromatic amino acid family metabolic process (GO:0009072)	2.68857310
99	lipopolysaccharide metabolic process (GO:0008653)	2.68359968
100	viral transcription (GO:0019083)	2.66233156

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.06080681
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.46795640
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.28739585
4	TAF15_26573619_Chip-Seq_HEK293_Human	3.24616316
5	IRF1_19129219_ChIP-ChIP_H3396_Human	3.10566112
6	FLI1_27457419_Chip-Seq_LIVER_Mouse	3.05175107
7	VDR_22108803_ChIP-Seq_LS180_Human	2.61629758
8	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.55171401
9	ELK1_19687146_ChIP-ChIP_HELA_Human	2.51787051
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.49245717
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.35686501
12	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.34998967
13	IGF1R_20145208_ChIP-Seq_DFB_Human	2.25294300
14	EGR1_19032775_ChIP-ChIP_M12_Human	2.22040927
15	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.08850563
16	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	2.01928660
17	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.99765106
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.99343882
19	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.98041157
20	P300_19829295_ChIP-Seq_ESCs_Human	1.96183496
21	GBX2_23144817_ChIP-Seq_PC3_Human	1.85066223
22	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.84278393
23	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.81968315
24	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.77428831
25	CBP_20019798_ChIP-Seq_JUKART_Human	1.77428831
26	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.73773563
27	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.69998549
28	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.67014111
29	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.66342697
30	EWS_26573619_Chip-Seq_HEK293_Human	1.65459615
31	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.64865005
32	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.63054994
33	FUS_26573619_Chip-Seq_HEK293_Human	1.62465494
34	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.61659808
35	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.59848857
36	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.56381732
37	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.56295047
38	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.54910259
39	E2F7_22180533_ChIP-Seq_HELA_Human	1.52380412
40	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.51340170
41	STAT3_23295773_ChIP-Seq_U87_Human	1.49641952
42	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.47610968
43	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.47411873
44	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.47320856
45	CDX2_22108803_ChIP-Seq_LS180_Human	1.44212180
46	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.40958068
47	NANOG_19829295_ChIP-Seq_ESCs_Human	1.39829950
48	SOX2_19829295_ChIP-Seq_ESCs_Human	1.39829950
49	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.38828732
50	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.37442622
51	SMAD4_21799915_ChIP-Seq_A2780_Human	1.35718105
52	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.35442083
53	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.35086131
54	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.34044993
55	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.33800059
56	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.32162263
57	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.31902404
58	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.31024733
59	GF1B_26923725_Chip-Seq_HPCs_Mouse	1.30947906
60	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.30390869
61	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.27549978
62	HOXB7_26014856_ChIP-Seq_BT474_Human	1.23268982
63	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.23161636
64	ER_23166858_ChIP-Seq_MCF-7_Human	1.20262111
65	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.20029716
66	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.19357040
67	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.18422788
68	TCF4_23295773_ChIP-Seq_U87_Human	1.18260446
69	MYC_18940864_ChIP-ChIP_HL60_Human	1.18145430
70	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17980323
71	TP53_16413492_ChIP-PET_HCT116_Human	1.17338568
72	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.16843309
73	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.16469865
74	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.15483780
75	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.14380911
76	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.13001277
77	NCOR_22424771_ChIP-Seq_293T_Human	1.10593041
78	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.10115406
79	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.09953171
80	TCF4_22108803_ChIP-Seq_LS180_Human	1.09618636
81	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.09213496
82	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.08773867
83	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.08773867
84	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.07986556
85	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.07828378
86	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.06910448
87	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.06670092
88	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.05752457
89	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.05199129
90	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.03423315
91	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.02370067
92	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.02184334
93	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.01841566
94	GATA4_25053715_ChIP-Seq_YYC3_Human	1.00852625
95	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.00251387
96	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.00157522
97	TP53_18474530_ChIP-ChIP_U2OS_Human	0.99342071
98	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.97570846
99	CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.97013169
100	TCF3_18692474_ChIP-Seq_MESCs_Mouse	0.96425049

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005171_absent_coat_pigmentation	5.16762316
2	MP0002653_abnormal_ependyma_morphology	4.44968478
3	MP0002837_dystrophic_cardiac_calcinosis	4.15768162
4	MP0003890_abnormal_embryonic-extraembry	4.05781563
5	MP0006054_spinal_hemorrhage	2.93426986
6	MP0003136_yellow_coat_color	2.89957299
7	MP0002163_abnormal_gland_morphology	2.84625419
8	MP0003183_abnormal_peptide_metabolism	2.84280063
9	MP0003195_calcinosis	2.63110602
10	MP0005379_endocrine/exocrine_gland_phen	2.53989740
11	MP0002138_abnormal_hepatobiliary_system	2.34305276
12	MP0002132_abnormal_respiratory_system	2.28015209
13	MP0002938_white_spotting	2.23836392
14	MP0003646_muscle_fatigue	2.13218558
15	MP0006292_abnormal_olfactory_placode	2.10751897
16	MP0003123_paternal_imprinting	2.05940961
17	MP0000537_abnormal_urethra_morphology	2.02838093
18	MP0002638_abnormal_pupillary_reflex	2.00773473
19	MP0000569_abnormal_digit_pigmentation	1.95279265
20	MP0001984_abnormal_olfaction	1.93592141
21	MP0005377_hearing/vestibular/ear_phenot	1.92733049
22	MP0003878_abnormal_ear_physiology	1.92733049
23	MP0004147_increased_porphyrin_level	1.80900429
24	MP0004957_abnormal_blastocyst_morpholog	1.69068146
25	MP0002971_abnormal_brown_adipose	1.62940073
26	MP0001188_hyperpigmentation	1.60584441
27	MP0000647_abnormal_sebaceous_gland	1.57757704
28	MP0004019_abnormal_vitamin_homeostasis	1.56745896
29	MP0002277_abnormal_respiratory_mucosa	1.54377275
30	MP0001501_abnormal_sleep_pattern	1.49227134
31	MP0005248_abnormal_Harderian_gland	1.48077461
32	MP0003186_abnormal_redox_activity	1.43787732
33	MP0003937_abnormal_limbs/digits/tail_de	1.43040703
34	MP0003121_genomic_imprinting	1.36367561
35	MP0006276_abnormal_autonomic_nervous	1.30938141
36	MP0003879_abnormal_hair_cell	1.26962119
37	MP0005085_abnormal_gallbladder_physiolo	1.19460037
38	MP0005666_abnormal_adipose_tissue	1.15541976
39	MP0000383_abnormal_hair_follicle	1.14911122
40	MP0001186_pigmentation_phenotype	1.14808042
41	MP0008995_early_reproductive_senescence	1.14773774
42	MP0003252_abnormal_bile_duct	1.14463777
43	MP0002075_abnormal_coat/hair_pigmentati	1.12625801
44	MP0002095_abnormal_skin_pigmentation	1.12097494
45	MP0003045_fibrosis	1.11048008
46	MP0004381_abnormal_hair_follicle	1.06419765
47	MP0009379_abnormal_foot_pigmentation	1.06379257
48	MP0001286_abnormal_eye_development	1.01527516
49	MP0008058_abnormal_DNA_repair	1.01091950
50	MP0002735_abnormal_chemical_nociception	0.99635903
51	MP0005551_abnormal_eye_electrophysiolog	0.97603434
52	MP0008872_abnormal_physiological_respon	0.97244552
53	MP0005670_abnormal_white_adipose	0.96743505
54	MP0002111_abnormal_tail_morphology	0.93649705
55	MP0003705_abnormal_hypodermis_morpholog	0.93255076
56	MP0000613_abnormal_salivary_gland	0.92275780
57	MP0002160_abnormal_reproductive_system	0.91931717
58	MP0001879_abnormal_lymphatic_vessel	0.91258369
59	MP0005365_abnormal_bile_salt	0.90956958
60	MP0002751_abnormal_autonomic_nervous	0.88675032
61	MP0005220_abnormal_exocrine_pancreas	0.87641042
62	MP0002233_abnormal_nose_morphology	0.87030035
63	MP0002168_other_aberrant_phenotype	0.85374993
64	MP0003567_abnormal_fetal_cardiomyocyte	0.85099211
65	MP0009765_abnormal_xenobiotic_induced	0.83927263
66	MP0001293_anophthalmia	0.80245324
67	MP0004215_abnormal_myocardial_fiber	0.80038510
68	MP0001324_abnormal_eye_pigmentation	0.79981170
69	MP0010094_abnormal_chromosome_stability	0.79434744
70	MP0000230_abnormal_systemic_arterial	0.79326541
71	MP0008932_abnormal_embryonic_tissue	0.79096780
72	MP0000371_diluted_coat_color	0.76651810
73	MP0003698_abnormal_male_reproductive	0.75718771
74	MP0009115_abnormal_fat_cell	0.75147248
75	MP0010352_gastrointestinal_tract_polyps	0.74280112
76	MP0002084_abnormal_developmental_patter	0.73625246
77	MP0005410_abnormal_fertilization	0.72839220
78	MP0000026_abnormal_inner_ear	0.72391162
79	MP0001756_abnormal_urination	0.72372766
80	MP0003942_abnormal_urinary_system	0.71735275
81	MP0001963_abnormal_hearing_physiology	0.70615592
82	MP0001697_abnormal_embryo_size	0.70445247
83	MP0000534_abnormal_ureter_morphology	0.69099606
84	MP0005187_abnormal_penis_morphology	0.67295383
85	MP0005195_abnormal_posterior_eye	0.66986030
86	MP0004142_abnormal_muscle_tone	0.66583299
87	MP0001986_abnormal_taste_sensitivity	0.65485169
88	MP0001346_abnormal_lacrimal_gland	0.65158277
89	MP0010678_abnormal_skin_adnexa	0.65045968
90	MP0001145_abnormal_male_reproductive	0.64916875
91	MP0002752_abnormal_somatic_nervous	0.64752604
92	MP0005389_reproductive_system_phenotype	0.63764147
93	MP0009053_abnormal_anal_canal	0.63110373
94	MP0008057_abnormal_DNA_replication	0.62279110
95	MP0002269_muscular_atrophy	0.61785180
96	MP0002210_abnormal_sex_determination	0.61150905
97	MP0005408_hypopigmentation	0.60965669
98	MP0005499_abnormal_olfactory_system	0.60516131
99	MP0005394_taste/olfaction_phenotype	0.60516131
100	MP0002254_reproductive_system_inflammat	0.60006244

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	6.26565524
2	Acanthocytosis (HP:0001927)	4.96097642
3	Cavernous hemangioma (HP:0001048)	4.33620423
4	Conjugated hyperbilirubinemia (HP:0002908)	4.31560255
5	Amelogenesis imperfecta (HP:0000705)	4.23815405
6	Pigmentary retinal degeneration (HP:0001146)	3.91827743
7	Birth length less than 3rd percentile (HP:0003561)	3.76092705
8	Focal motor seizures (HP:0011153)	3.48130245
9	Vertebral arch anomaly (HP:0008438)	3.46048566
10	Pancreatic fibrosis (HP:0100732)	3.44859437
11	Chorioretinal atrophy (HP:0000533)	3.33852636
12	Parakeratosis (HP:0001036)	3.25780231
13	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.24015864
14	Carpal bone hypoplasia (HP:0001498)	3.16849519
15	Abnormality of the lumbar spine (HP:0100712)	2.88740175
16	Colon cancer (HP:0003003)	2.85028831
17	Broad ribs (HP:0000885)	2.84920138
18	Pancreatic cysts (HP:0001737)	2.81854241
19	Diastasis recti (HP:0001540)	2.76000526
20	Short middle phalanx of the 5th finger (HP:0004220)	2.71408807
21	Nephrogenic diabetes insipidus (HP:0009806)	2.71147572
22	Neoplasm of the small intestine (HP:0100833)	2.62739862
23	Rib fusion (HP:0000902)	2.62725737
24	Biliary tract neoplasm (HP:0100574)	2.57019952
25	Pendular nystagmus (HP:0012043)	2.50510432
26	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.47121388
27	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.47121388
28	J-shaped sella turcica (HP:0002680)	2.45782161
29	Ectopic kidney (HP:0000086)	2.38733961
30	Angiofibromas (HP:0010615)	2.34705538
31	Adenoma sebaceum (HP:0009720)	2.34705538
32	Abnormality of abdominal situs (HP:0011620)	2.34084912
33	Abdominal situs inversus (HP:0003363)	2.34084912
34	Breast aplasia (HP:0100783)	2.32564509
35	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.30013107
36	Abnormality of the pons (HP:0007361)	2.24781766
37	Clumsiness (HP:0002312)	2.23933466
38	Thickened calvaria (HP:0002684)	2.23189584
39	Hypoplasia of the pons (HP:0012110)	2.23036721
40	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.22053014
41	Poikilocytosis (HP:0004447)	2.21830673
42	Abnormal biliary tract morphology (HP:0012440)	2.20310438
43	Rectal prolapse (HP:0002035)	2.19221815
44	Broad alveolar ridges (HP:0000187)	2.16626713
45	Hip dysplasia (HP:0001385)	2.15594317
46	Anomalous pulmonary venous return (HP:0010772)	2.14805425
47	Concave nail (HP:0001598)	2.13918772
48	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.13784735
49	Cutaneous finger syndactyly (HP:0010554)	2.10988515
50	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.09605238
51	Abnormality of alanine metabolism (HP:0010916)	2.09605238
52	Hyperalaninemia (HP:0003348)	2.09605238
53	Febrile seizures (HP:0002373)	2.07442979
54	Hypoplastic labia majora (HP:0000059)	2.06790651
55	True hermaphroditism (HP:0010459)	2.06595240
56	Hypoplasia of the fovea (HP:0007750)	2.04090627
57	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.04090627
58	Genetic anticipation (HP:0003743)	2.02298005
59	Neonatal respiratory distress (HP:0002643)	2.01915719
60	Nonprogressive disorder (HP:0003680)	2.01686662
61	Beaking of vertebral bodies (HP:0004568)	2.01657772
62	Gonadotropin excess (HP:0000837)	2.01277527
63	Abnormality of the parathyroid morphology (HP:0011766)	1.99942498
64	Aplasia/Hypoplasia of the breasts (HP:0010311)	1.98588596
65	Abnormal rod and cone electroretinograms (HP:0008323)	1.93984190
66	Volvulus (HP:0002580)	1.93912879
67	Aplastic anemia (HP:0001915)	1.93021304
68	Hypochromic microcytic anemia (HP:0004840)	1.92319874
69	Anencephaly (HP:0002323)	1.88813943
70	Ependymoma (HP:0002888)	1.88368531
71	Conjunctival telangiectasia (HP:0000524)	1.87904600
72	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	1.86486887
73	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.85808262
74	Abnormality of the labia majora (HP:0012881)	1.85635393
75	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.85356091
76	Aortic regurgitation (HP:0001659)	1.85001043
77	Neoplasm of the rectum (HP:0100743)	1.83076804
78	Medulloblastoma (HP:0002885)	1.82444177
79	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.82073615
80	Congenital ichthyosiform erythroderma (HP:0007431)	1.81441265
81	Abnormality of the corticospinal tract (HP:0002492)	1.81003416
82	Broad-based gait (HP:0002136)	1.80925648
83	Abnormality of the ileum (HP:0001549)	1.80632078
84	Dyskinesia (HP:0100660)	1.80505206
85	Small hand (HP:0200055)	1.79995821
86	Abnormality of the pulmonary veins (HP:0011718)	1.79211973
87	Postaxial foot polydactyly (HP:0001830)	1.78744714
88	Meckel diverticulum (HP:0002245)	1.77670317
89	Deformed sella turcica (HP:0002681)	1.77393038
90	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	1.76761078
91	Thoracolumbar scoliosis (HP:0002944)	1.75938217
92	Anal stenosis (HP:0002025)	1.75351294
93	Irregular epiphyses (HP:0010582)	1.75007870
94	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.72622721
95	Cutaneous syndactyly (HP:0012725)	1.71119426
96	Curly hair (HP:0002212)	1.70725173
97	Wide intermamillary distance (HP:0006610)	1.68989912
98	Hypophosphatemic rickets (HP:0004912)	1.68690180
99	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.68581341
100	Rhabdomyosarcoma (HP:0002859)	1.68562702

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LATS1	5.23800667
2	STK38L	4.76592849
3	FRK	4.57990920
4	MST4	3.64590260
5	PIK3CA	3.50572466
6	ACVR1B	2.97031973
7	LATS2	2.91964635
8	PRKD3	2.84136012
9	NLK	2.31247269
10	PASK	2.08257621
11	MAP4K2	2.04014428
12	BRD4	1.97895089
13	STK24	1.84731188
14	DYRK3	1.80725365
15	ADRBK2	1.77711690
16	NUAK1	1.72835041
17	PINK1	1.70266808
18	MELK	1.69604243
19	FGFR1	1.61625915
20	TGFBR1	1.57172916
21	RPS6KA4	1.52733912
22	EIF2AK3	1.48913814
23	TRIM28	1.48847521
24	GRK1	1.40970349
25	STK3	1.38545464
26	BMPR1B	1.31425560
27	ADRBK1	1.30458880
28	NEK1	1.22539153
29	TNIK	1.20818054
30	PTK6	1.18076946
31	MAP3K2	1.12546927
32	EPHB2	1.12058191
33	AKT3	1.11831433
34	TIE1	1.09476358
35	KSR1	1.06672615
36	WNK4	1.04937469
37	PLK4	1.02760459
38	ZAK	1.00740458
39	WNK3	0.97428562
40	NTRK2	0.95556418
41	CLK1	0.94827265
42	TAF1	0.94082653
43	CAMKK2	0.93157371
44	VRK1	0.89808804
45	SGK2	0.88671786
46	YES1	0.81972254
47	MKNK2	0.78684487
48	BCR	0.77908738
49	BRSK2	0.75712846
50	ERBB2	0.72191646
51	BMPR2	0.66937781
52	MKNK1	0.66574568
53	CAMK4	0.65599802
54	DYRK1B	0.63054414
55	STK38	0.62910131
56	PLK2	0.62261315
57	NEK2	0.60811585
58	PIM1	0.60578224
59	EPHA2	0.59094718
60	CAMK2A	0.58957736
61	PRKAA2	0.58692675
62	RPS6KA5	0.57590443
63	PRKCG	0.55973612
64	OXSR1	0.55966784
65	CHEK2	0.54997032
66	MAP2K2	0.54518585
67	MAPK15	0.47189808
68	EPHA4	0.46402666
69	AKT2	0.45388470
70	MAPK13	0.45258379
71	CSNK1A1L	0.42401756
72	MAPK7	0.40945049
73	BMX	0.40521127
74	STK39	0.38922952
75	PRKCE	0.38375921
76	CAMK1	0.36745903
77	KSR2	0.34785214
78	PLK3	0.34299851
79	PLK1	0.31428294
80	RIPK4	0.30802423
81	SGK3	0.29928066
82	AURKB	0.29195884
83	PDK2	0.28631107
84	SGK223	0.26866223
85	SGK494	0.26866223
86	CAMK2B	0.26501588
87	CSNK1A1	0.25733636
88	PIK3CG	0.25661183
89	MAP3K9	0.24452656
90	OBSCN	0.23897846
91	NEK9	0.23159208
92	TXK	0.22204374
93	CAMK2G	0.21720794
94	ERBB4	0.21487347
95	SIK3	0.20614174
96	INSR	0.19254891
97	PRKACA	0.18958603
98	CAMK1D	0.18937081
99	SGK1	0.18376550
100	AKT1	0.17543020

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Cyanoamino acid metabolism_Homo sapiens_hsa00460	4.45013417
2	Phototransduction_Homo sapiens_hsa04744	4.13398540
3	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	4.05470906
4	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.49096823
5	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	3.31119777
6	Taste transduction_Homo sapiens_hsa04742	2.97367891
7	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.72507901
8	Ribosome_Homo sapiens_hsa03010	2.53757522
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.47247699
10	Basal transcription factors_Homo sapiens_hsa03022	2.43955635
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.39786574
12	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.39018593
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.30895713
14	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	2.21119799
15	Mismatch repair_Homo sapiens_hsa03430	2.18011820
16	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.03712012
17	Selenocompound metabolism_Homo sapiens_hsa00450	1.81827034
18	Propanoate metabolism_Homo sapiens_hsa00640	1.79087838
19	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.69872402
20	Homologous recombination_Homo sapiens_hsa03440	1.54636785
21	Protein export_Homo sapiens_hsa03060	1.54579732
22	Glutathione metabolism_Homo sapiens_hsa00480	1.44248544
23	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.43599154
24	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.40813123
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.37532732
26	RNA transport_Homo sapiens_hsa03013	1.34338297
27	One carbon pool by folate_Homo sapiens_hsa00670	1.19831118
28	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.18724995
29	Fatty acid degradation_Homo sapiens_hsa00071	1.07979528
30	Calcium signaling pathway_Homo sapiens_hsa04020	1.05800961
31	Nitrogen metabolism_Homo sapiens_hsa00910	1.02090229
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.00474874
33	beta-Alanine metabolism_Homo sapiens_hsa00410	1.00214011
34	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.97367876
35	RNA degradation_Homo sapiens_hsa03018	0.95595510
36	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.93030425
37	Nucleotide excision repair_Homo sapiens_hsa03420	0.92559683
38	p53 signaling pathway_Homo sapiens_hsa04115	0.92507849
39	Retinol metabolism_Homo sapiens_hsa00830	0.88041186
40	Pyruvate metabolism_Homo sapiens_hsa00620	0.86400912
41	Caffeine metabolism_Homo sapiens_hsa00232	0.85513540
42	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.82713631
43	Chemical carcinogenesis_Homo sapiens_hsa05204	0.82325717
44	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.76089744
45	Olfactory transduction_Homo sapiens_hsa04740	0.75775516
46	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.74859474
47	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.72939334
48	Glycerolipid metabolism_Homo sapiens_hsa00561	0.71679580
49	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.68572163
50	Steroid biosynthesis_Homo sapiens_hsa00100	0.67228141
51	Thyroid cancer_Homo sapiens_hsa05216	0.65426403
52	Long-term potentiation_Homo sapiens_hsa04720	0.64961500
53	VEGF signaling pathway_Homo sapiens_hsa04370	0.64310304
54	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.63807750
55	Glutamatergic synapse_Homo sapiens_hsa04724	0.62961586
56	Tyrosine metabolism_Homo sapiens_hsa00350	0.62165186
57	Wnt signaling pathway_Homo sapiens_hsa04310	0.61225897
58	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.60140771
59	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.57393332
60	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.56807528
61	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.54375264
62	Serotonergic synapse_Homo sapiens_hsa04726	0.53118461
63	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.52528277
64	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.51874461
65	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.51748887
66	Histidine metabolism_Homo sapiens_hsa00340	0.50704616
67	Linoleic acid metabolism_Homo sapiens_hsa00591	0.50619986
68	Folate biosynthesis_Homo sapiens_hsa00790	0.46278092
69	Cell cycle_Homo sapiens_hsa04110	0.45899030
70	Renin secretion_Homo sapiens_hsa04924	0.44970959
71	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.44618582
72	Nicotine addiction_Homo sapiens_hsa05033	0.43353199
73	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.43157820
74	ABC transporters_Homo sapiens_hsa02010	0.38187095
75	Metabolic pathways_Homo sapiens_hsa01100	0.37353886
76	Viral carcinogenesis_Homo sapiens_hsa05203	0.37160304
77	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.36366269
78	MicroRNAs in cancer_Homo sapiens_hsa05206	0.34841682
79	Hippo signaling pathway_Homo sapiens_hsa04390	0.33367846
80	Basal cell carcinoma_Homo sapiens_hsa05217	0.33176856
81	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.32952763
82	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.31881757
83	Non-homologous end-joining_Homo sapiens_hsa03450	0.30930439
84	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.30435911
85	Axon guidance_Homo sapiens_hsa04360	0.30296935
86	RNA polymerase_Homo sapiens_hsa03020	0.28777781
87	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.26511822
88	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.24685072
89	GABAergic synapse_Homo sapiens_hsa04727	0.22527634
90	Alcoholism_Homo sapiens_hsa05034	0.22426647
91	Spliceosome_Homo sapiens_hsa03040	0.22153593
92	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.22119805
93	Oocyte meiosis_Homo sapiens_hsa04114	0.20398377
94	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.20397202
95	Phenylalanine metabolism_Homo sapiens_hsa00360	0.18257862
96	Collecting duct acid secretion_Homo sapiens_hsa04966	0.17758034
97	Amphetamine addiction_Homo sapiens_hsa05031	0.17733303
98	Adherens junction_Homo sapiens_hsa04520	0.17250755
99	Carbon metabolism_Homo sapiens_hsa01200	0.16953500
100	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.16458089

BNIP3P39

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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