BNIP3P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of synaptic transmission, GABAergic (GO:0032230)8.49045747
2positive regulation of digestive system process (GO:0060456)7.16271816
3regulation of glucocorticoid secretion (GO:2000849)6.88002664
4positive regulation of steroid hormone secretion (GO:2000833)6.83314470
5negative regulation of heart rate (GO:0010459)6.79747755
6regulation of action potential (GO:0098900)6.19102294
7regulation of corticosteroid hormone secretion (GO:2000846)5.87410859
8negative regulation of mast cell activation (GO:0033004)5.16955756
9positive regulation of vesicle fusion (GO:0031340)4.85004005
10microtubule nucleation (GO:0007020)4.82361035
11facial nerve structural organization (GO:0021612)4.74551006
12positive regulation of renal sodium excretion (GO:0035815)4.72628753
13semaphorin-plexin signaling pathway (GO:0071526)4.19956467
14regulation of steroid hormone secretion (GO:2000831)4.19675332
15regulation of synaptic transmission, GABAergic (GO:0032228)4.14671246
16substrate-dependent cell migration (GO:0006929)3.97465688
17negative regulation of calcium ion transport into cytosol (GO:0010523)3.85470583
18tyrosine phosphorylation of STAT protein (GO:0007260)3.84131645
19myelination in peripheral nervous system (GO:0022011)3.74654310
20peripheral nervous system axon ensheathment (GO:0032292)3.74654310
21negative regulation of heart contraction (GO:0045822)3.68054740
22auditory behavior (GO:0031223)3.67593365
23righting reflex (GO:0060013)3.63837168
24establishment of protein localization to Golgi (GO:0072600)3.56190234
25regulation of vesicle fusion (GO:0031338)3.48160204
26hemidesmosome assembly (GO:0031581)3.44356775
27ovulation cycle (GO:0042698)3.40864457
28neuronal action potential propagation (GO:0019227)3.40372471
29ganglion development (GO:0061548)3.40058518
30positive regulation of developmental pigmentation (GO:0048087)3.39453549
31retrograde transport, vesicle recycling within Golgi (GO:0000301)3.31068521
32interleukin-6-mediated signaling pathway (GO:0070102)3.26685916
33regulation of axon extension involved in axon guidance (GO:0048841)3.25618338
34response to pain (GO:0048265)3.22812765
35protein targeting to Golgi (GO:0000042)3.22460884
36cranial nerve structural organization (GO:0021604)3.22035216
37smooth muscle tissue development (GO:0048745)3.17277669
38detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.15366598
39regulation of protein heterodimerization activity (GO:0043497)3.13855490
40regulation of renal sodium excretion (GO:0035813)3.09864405
41response to morphine (GO:0043278)3.05679349
42presynaptic membrane assembly (GO:0097105)3.05165940
43presynaptic membrane organization (GO:0097090)3.00863316
44positive regulation of synapse assembly (GO:0051965)2.99740509
45glomerulus development (GO:0032835)2.99555584
46glomerular visceral epithelial cell development (GO:0072015)2.97705191
47negative regulation of anoikis (GO:2000811)2.95289929
48regulation of axon guidance (GO:1902667)2.95005465
49axonal fasciculation (GO:0007413)2.94818979
50retina vasculature morphogenesis in camera-type eye (GO:0061299)2.93045740
51response to isoquinoline alkaloid (GO:0014072)2.92840611
52UDP-N-acetylglucosamine metabolic process (GO:0006047)2.91542452
53membrane assembly (GO:0071709)2.89231390
54motor neuron axon guidance (GO:0008045)2.89027166
55regulation of pigment cell differentiation (GO:0050932)2.88093348
56activation of Rac GTPase activity (GO:0032863)2.88007130
57establishment of protein localization to vacuole (GO:0072666)2.87714356
58protein targeting to vacuole (GO:0006623)2.87714356
59protein targeting to lysosome (GO:0006622)2.87714356
60negative regulation of blood circulation (GO:1903523)2.86702870
61long-term memory (GO:0007616)2.86524543
62acidic amino acid transport (GO:0015800)2.83382910
63early endosome to late endosome transport (GO:0045022)2.82890299
64negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.81561833
65positive regulation of smooth muscle cell migration (GO:0014911)2.80824566
66regulation of digestive system process (GO:0044058)2.79551717
67establishment of spindle orientation (GO:0051294)2.77316210
68regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.77218830
69regulation of histone H3-K27 methylation (GO:0061085)2.75931944
70regulation of endocrine process (GO:0044060)2.75364866
71centrosome localization (GO:0051642)2.75233737
72dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.74723682
73axon extension involved in axon guidance (GO:0048846)2.73573213
74neuron projection extension involved in neuron projection guidance (GO:1902284)2.73573213
75inositol metabolic process (GO:0006020)2.71533469
76L-glutamate transport (GO:0015813)2.67710199
77positive regulation of epithelial cell migration (GO:0010634)2.66486236
78histone H3-K4 trimethylation (GO:0080182)2.66382176
79regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.65448308
80mechanosensory behavior (GO:0007638)2.65339877
81glucocorticoid receptor signaling pathway (GO:0042921)2.63838026
82renal filtration (GO:0097205)2.63784267
83detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.63058428
84cell adhesion mediated by integrin (GO:0033627)2.62728569
85protein localization to synapse (GO:0035418)2.61285387
86mesodermal cell differentiation (GO:0048333)2.59807854
87regulation of cholesterol homeostasis (GO:2000188)2.58642300
88negative regulation of axon extension involved in axon guidance (GO:0048843)2.56822004
89regulation of hippo signaling (GO:0035330)2.56122991
90coronary vasculature morphogenesis (GO:0060977)2.55911862
91homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.54902052
92regulation of MHC class I biosynthetic process (GO:0045343)2.54338315
93positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)2.54116063
94dermatan sulfate biosynthetic process (GO:0030208)2.53776421
95multicellular organism reproduction (GO:0032504)2.52926958
96retinal ganglion cell axon guidance (GO:0031290)2.52192561
97regulation of excretion (GO:0044062)2.52163553
98chemosensory behavior (GO:0007635)2.51591083
99tachykinin receptor signaling pathway (GO:0007217)11.1116731
100positive regulation of action potential (GO:0045760)11.0640319

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.38109757
2SMAD_19615063_ChIP-ChIP_OVARY_Human3.97317814
3GBX2_23144817_ChIP-Seq_PC3_Human3.81876658
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.63223805
5VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human3.10859780
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.79335641
7CDX2_19796622_ChIP-Seq_MESCs_Mouse2.61665654
8SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.50118004
9AHR_22903824_ChIP-Seq_MCF-7_Human2.45159013
10FUS_26573619_Chip-Seq_HEK293_Human2.39597819
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.39075089
12ZNF217_24962896_ChIP-Seq_MCF-7_Human2.38529640
13AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.26756386
14AR_21572438_ChIP-Seq_LNCaP_Human2.25362519
15PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.16215022
16TAF15_26573619_Chip-Seq_HEK293_Human2.09140372
17NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human2.07549681
18ARNT_22903824_ChIP-Seq_MCF-7_Human2.04061534
19CJUN_26792858_Chip-Seq_BT549_Human1.98799058
20STAT3_23295773_ChIP-Seq_U87_Human1.93988905
21NR3C1_21868756_ChIP-Seq_MCF10A_Human1.93169906
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.91564311
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.88824198
24SMAD4_21799915_ChIP-Seq_A2780_Human1.86499382
25CTNNB1_20460455_ChIP-Seq_HCT116_Human1.78781168
26NRF2_20460467_ChIP-Seq_MEFs_Mouse1.72772096
27NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.72772096
28TP53_18474530_ChIP-ChIP_U2OS_Human1.71858233
29TRIM28_21343339_ChIP-Seq_HEK293_Human1.71203721
30PIAS1_25552417_ChIP-Seq_VCAP_Human1.68928541
31TP53_16413492_ChIP-PET_HCT116_Human1.68576252
32IGF1R_20145208_ChIP-Seq_DFB_Human1.67081798
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.62043306
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.58909034
35ESR1_15608294_ChIP-ChIP_MCF-7_Human1.56327767
36BRD4_25478319_ChIP-Seq_HGPS_Human1.55959403
37RXR_22108803_ChIP-Seq_LS180_Human1.52962947
38FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.52003064
39OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49531121
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46513682
41GATA2_21666600_ChIP-Seq_HMVEC_Human1.45962720
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.44992418
43ER_23166858_ChIP-Seq_MCF-7_Human1.44923935
44IRF8_22096565_ChIP-ChIP_GC-B_Human1.44792707
45ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.41809245
46P300_19829295_ChIP-Seq_ESCs_Human1.40955272
47PPAR_26484153_Chip-Seq_NCI-H1993_Human1.40627192
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40523976
49FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.39371522
50SOX2_21211035_ChIP-Seq_LN229_Gbm1.38188546
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34904133
52TCF4_23295773_ChIP-Seq_U87_Human1.33716251
53TCF4_18268006_ChIP-ChIP_LS174T_Human1.33217342
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.33005752
55SMAD3_21741376_ChIP-Seq_HESCs_Human1.32275117
56TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.32217672
57TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31993257
58JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31623438
59FOXM1_26456572_ChIP-Seq_MCF-7_Human1.31592354
60SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.30313745
61SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.30313745
62YAP1_20516196_ChIP-Seq_MESCs_Mouse1.29023493
63EWS_26573619_Chip-Seq_HEK293_Human1.24528602
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24382920
65TP63_17297297_ChIP-ChIP_HaCaT_Human1.22462762
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.22083446
67SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.21306154
68CBP_20019798_ChIP-Seq_JUKART_Human1.18807431
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18807431
70KDM2B_26808549_Chip-Seq_REH_Human1.18432784
71AR_25329375_ChIP-Seq_VCAP_Human1.15515316
72RUNX2_22187159_ChIP-Seq_PCA_Human1.14702631
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14299540
74HIF1A_21447827_ChIP-Seq_MCF-7_Human1.13701650
75PRDM14_20953172_ChIP-Seq_ESCs_Human1.11842786
76CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.11471885
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10874580
78CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10677706
79HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07909050
80AR_19668381_ChIP-Seq_PC3_Human1.07298253
81BCAT_22108803_ChIP-Seq_LS180_Human1.07207678
82TP63_23658742_ChIP-Seq_EP156T_Human1.06696626
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05939508
84FOXA2_19822575_ChIP-Seq_HepG2_Human1.05937837
85VDR_22108803_ChIP-Seq_LS180_Human1.05676344
86Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04727658
87SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04684386
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04314720
89EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03168958
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02606966
91E2F1_18555785_Chip-Seq_ESCs_Mouse1.01784926
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00848572
93NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.98423071
94SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.97321412
95SMAD4_21741376_ChIP-Seq_HESCs_Human0.96670279
96SOX9_26525672_Chip-Seq_HEART_Mouse0.96450752
97STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95892751
98SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.95323495
99WT1_19549856_ChIP-ChIP_CCG9911_Human0.94210810
100SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94210474

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010386_abnormal_urinary_bladder8.11221456
2MP0004859_abnormal_synaptic_plasticity3.76392289
3MP0003045_fibrosis3.10366674
4MP0005623_abnormal_meninges_morphology2.83095190
5MP0003950_abnormal_plasma_membrane2.75853887
6MP0005423_abnormal_somatic_nervous2.57436889
7MP0003879_abnormal_hair_cell2.54884635
8MP0003123_paternal_imprinting2.51812707
9MP0010368_abnormal_lymphatic_system2.42429862
10MP0004272_abnormal_basement_membrane2.14577613
11MP0001879_abnormal_lymphatic_vessel2.06844854
12MP0002168_other_aberrant_phenotype2.05166547
13MP0002822_catalepsy2.05148595
14MP0002332_abnormal_exercise_endurance2.03415977
15MP0005076_abnormal_cell_differentiation2.00148082
16MP0005670_abnormal_white_adipose1.92679836
17MP0001348_abnormal_lacrimal_gland1.87653101
18MP0000733_abnormal_muscle_development1.75392589
19MP0005187_abnormal_penis_morphology1.74060506
20MP0001486_abnormal_startle_reflex1.73577362
21MP0008057_abnormal_DNA_replication1.71418901
22MP0002736_abnormal_nociception_after1.68798573
23MP0005646_abnormal_pituitary_gland1.63743251
24MP0000569_abnormal_digit_pigmentation1.60718997
25MP0009046_muscle_twitch1.60417140
26MP0000647_abnormal_sebaceous_gland1.57742399
27MP0000013_abnormal_adipose_tissue1.54343332
28MP0009697_abnormal_copulation1.54082808
29MP0003091_abnormal_cell_migration1.48333224
30MP0001970_abnormal_pain_threshold1.48193176
31MP0000778_abnormal_nervous_system1.42760742
32MP0000383_abnormal_hair_follicle1.40192831
33MP0004510_myositis1.37707806
34MP0001968_abnormal_touch/_nociception1.36900251
35MP0003635_abnormal_synaptic_transmissio1.34493772
36MP0003279_aneurysm1.32432638
37MP0002177_abnormal_outer_ear1.25401907
38MP0002572_abnormal_emotion/affect_behav1.24359654
39MP0002932_abnormal_joint_morphology1.24351875
40MP0004134_abnormal_chest_morphology1.22948894
41MP0002735_abnormal_chemical_nociception1.21422705
42MP0003385_abnormal_body_wall1.18588581
43MP0002184_abnormal_innervation1.18474015
44MP0002272_abnormal_nervous_system1.16417049
45MP0001299_abnormal_eye_distance/1.14335965
46MP0005503_abnormal_tendon_morphology1.13722319
47MP0002733_abnormal_thermal_nociception1.12119959
48MP0004145_abnormal_muscle_electrophysio1.10562987
49MP0004270_analgesia1.10539148
50MP0002063_abnormal_learning/memory/cond1.10217758
51MP0003121_genomic_imprinting1.08009176
52MP0000427_abnormal_hair_cycle1.06937864
53MP0000751_myopathy1.05029035
54MP0001905_abnormal_dopamine_level1.04174666
55MP0005395_other_phenotype1.03296275
56MP0005023_abnormal_wound_healing0.99147534
57MP0002734_abnormal_mechanical_nocicepti0.99103493
58MP0001529_abnormal_vocalization0.98821873
59MP0009250_abnormal_appendicular_skeleto0.97705733
60MP0010352_gastrointestinal_tract_polyps0.96778933
61MP0001340_abnormal_eyelid_morphology0.95001769
62MP0003890_abnormal_embryonic-extraembry0.93831032
63MP0002896_abnormal_bone_mineralization0.92135799
64MP0001915_intracranial_hemorrhage0.91805753
65MP0000465_gastrointestinal_hemorrhage0.91256902
66MP0002067_abnormal_sensory_capabilities0.90013508
67MP0000003_abnormal_adipose_tissue0.90000418
68MP0010678_abnormal_skin_adnexa0.87123320
69MP0004233_abnormal_muscle_weight0.85439761
70MP0006054_spinal_hemorrhage0.85180663
71MP0003566_abnormal_cell_adhesion0.84028747
72MP0003315_abnormal_perineum_morphology0.82599430
73MP0005257_abnormal_intraocular_pressure0.82155353
74MP0002933_joint_inflammation0.77787643
75MP0002234_abnormal_pharynx_morphology0.76149123
76MP0002109_abnormal_limb_morphology0.75984149
77MP0002925_abnormal_cardiovascular_devel0.74300750
78MP0002089_abnormal_postnatal_growth/wei0.73266204
79MP0003690_abnormal_glial_cell0.72895294
80MP0002928_abnormal_bile_duct0.72607318
81MP0010307_abnormal_tumor_latency0.71638028
82MP0003252_abnormal_bile_duct0.71067691
83MP0002877_abnormal_melanocyte_morpholog0.70849409
84MP0002970_abnormal_white_adipose0.70579848
85MP0001919_abnormal_reproductive_system0.70395916
86MP0001756_abnormal_urination0.70083511
87MP0005386_behavior/neurological_phenoty0.69884684
88MP0004924_abnormal_behavior0.69884684
89MP0008569_lethality_at_weaning0.69746862
90MP0004043_abnormal_pH_regulation0.68228112
91MP0003221_abnormal_cardiomyocyte_apopto0.68067615
92MP0002138_abnormal_hepatobiliary_system0.67720362
93MP0003868_abnormal_feces_composition0.67240686
94MP0003329_amyloid_beta_deposits0.66386007
95MP0005266_abnormal_metabolism0.66214927
96MP0001501_abnormal_sleep_pattern0.65732980
97MP0004811_abnormal_neuron_physiology0.64935812
98MP0005167_abnormal_blood-brain_barrier0.64585061
99MP0002115_abnormal_skeleton_extremities0.63309014
100MP0002882_abnormal_neuron_morphology0.62971455

Predicted human phenotypes

RankGene SetZ-score
1Thoracolumbar scoliosis (HP:0002944)5.89622989
2Fibular aplasia (HP:0002990)4.98529477
3Broad-based gait (HP:0002136)4.01613520
4Genetic anticipation (HP:0003743)3.81631446
5Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.69582622
6Overlapping toe (HP:0001845)3.69248618
7Advanced eruption of teeth (HP:0006288)3.58614604
8Natal tooth (HP:0000695)3.52614143
9Broad face (HP:0000283)3.50545469
10Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)3.40437396
11Down-sloping shoulders (HP:0200021)3.27279387
12Neonatal short-limb short stature (HP:0008921)3.21871073
13Tented upper lip vermilion (HP:0010804)3.16551173
14Submucous cleft hard palate (HP:0000176)2.96719213
15Insidious onset (HP:0003587)2.89052681
16Termporal pattern (HP:0011008)2.89052681
17Absent speech (HP:0001344)2.88564860
18Prominent nose (HP:0000448)2.85160067
19Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.76577011
20Adactyly (HP:0009776)2.69437380
21Tracheomalacia (HP:0002779)2.64845328
22Abnormality of the musculature of the pelvis (HP:0001469)2.64458733
23Abnormality of the hip-girdle musculature (HP:0001445)2.64458733
24Protruding tongue (HP:0010808)2.63620516
25Short chin (HP:0000331)2.58641076
26Abnormality of the epiphyses of the hand (HP:0005924)2.55402299
27Fair hair (HP:0002286)2.54952741
28Shoulder girdle muscle weakness (HP:0003547)2.53238841
29Chin dimple (HP:0010751)2.51089935
30Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.50380550
31Degeneration of the lateral corticospinal tracts (HP:0002314)2.50380550
32Clumsiness (HP:0002312)2.48530643
33Abnormality of the proximal phalanges of the hand (HP:0009834)2.48486474
34Pelvic girdle muscle weakness (HP:0003749)2.48358163
35Short nail (HP:0001799)2.44783161
36Abnormal finger flexion creases (HP:0006143)2.43713693
37Urinary urgency (HP:0000012)2.42446367
38Limited hip movement (HP:0008800)2.40951607
39Global brain atrophy (HP:0002283)2.39974963
40Hip dysplasia (HP:0001385)2.38148460
41Urinary bladder sphincter dysfunction (HP:0002839)2.35684385
42Inappropriate behavior (HP:0000719)2.35433820
43Difficulty climbing stairs (HP:0003551)2.31851046
44Decreased muscle mass (HP:0003199)2.31135391
45Aplasia/Hypoplasia of the fibula (HP:0006492)2.30677158
46Abnormality involving the epiphyses of the upper limbs (HP:0003839)2.30272190
47Overgrowth (HP:0001548)2.29344816
48Heterotopia (HP:0002282)2.22624931
49Abnormality of the corticospinal tract (HP:0002492)2.21686271
50Radial bowing (HP:0002986)2.20932923
51Atrophic scars (HP:0001075)2.19801655
52Neurofibrillary tangles (HP:0002185)2.19229393
53Increased density of long bones (HP:0006392)2.18243171
54Spondylolisthesis (HP:0003302)2.14078848
55Syringomyelia (HP:0003396)2.13982107
56Spinal cord lesions (HP:0100561)2.13982107
57Hand muscle atrophy (HP:0009130)2.13421698
58Hyperacusis (HP:0010780)2.11616382
59Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.07357637
60Absent phalangeal crease (HP:0006109)2.04964524
61Protruding ear (HP:0000411)2.04820581
62Widely spaced teeth (HP:0000687)2.04257030
63Synophrys (HP:0000664)2.02867176
64Morphological abnormality of the middle ear (HP:0008609)2.01875950
65Menstrual irregularities (HP:0000858)2.00172511
66Poikiloderma (HP:0001029)1.98688362
67Exotropia (HP:0000577)1.96807453
68Cubitus valgus (HP:0002967)1.96714488
69Complete atrioventricular canal defect (HP:0001674)1.94926345
70Upper limb muscle weakness (HP:0003484)1.93972292
71Wrist flexion contracture (HP:0001239)1.92109694
72Upper limb amyotrophy (HP:0009129)1.92039859
73Distal upper limb amyotrophy (HP:0007149)1.92039859
74Impaired vibration sensation in the lower limbs (HP:0002166)1.90090737
75Synostosis of carpal bones (HP:0005048)1.87584659
76Urethral obstruction (HP:0000796)1.87555974
77Generalized hypopigmentation of hair (HP:0011358)1.85600727
78Distal lower limb amyotrophy (HP:0008944)1.83910635
79Open mouth (HP:0000194)1.82380435
80Cerebellar dysplasia (HP:0007033)1.82193993
81Limb-girdle muscle weakness (HP:0003325)1.82110428
82Thick eyebrow (HP:0000574)1.82076851
8311 pairs of ribs (HP:0000878)1.77854032
84Entropion (HP:0000621)1.75094153
85Renovascular hypertension (HP:0100817)1.74748263
86Glucose intolerance (HP:0000833)1.74359483
87Mild short stature (HP:0003502)1.73762658
88Aplasia/Hypoplasia of the tibia (HP:0005772)1.73687466
89Spinal cord compression (HP:0002176)1.72431621
90Febrile seizures (HP:0002373)1.71926391
91Hypoplasia of the brainstem (HP:0002365)1.71655861
92Aplasia/Hypoplasia of the brainstem (HP:0007362)1.71655861
93Abnormality of the distal phalanx of the thumb (HP:0009617)1.70183429
94Neonatal death (HP:0003811)1.68484951
95Hypotelorism (HP:0000601)1.67757369
96Abnormal hand bone ossification (HP:0010660)1.66902657
97High anterior hairline (HP:0009890)1.64675184
98Bronchomalacia (HP:0002780)1.64582944
99Lower limb muscle weakness (HP:0007340)1.64389785
100Difficulty running (HP:0009046)1.63881637

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.52237718
2MAP3K45.01578388
3MAP2K74.63385937
4EPHA23.25113458
5CASK2.70684352
6ERBB42.68178127
7LMTK22.56799038
8MARK12.55434441
9FER2.53226977
10MET2.48955195
11PKN22.48538024
12SIK22.38264697
13CDK122.00755826
14BCR1.91090764
15MAP2K41.86728041
16PTK21.83574520
17MAP3K61.81973806
18WNK31.70356040
19MAP4K21.65010919
20PDGFRA1.61362201
21MAPK131.58323113
22FLT31.44065700
23CDC42BPA1.43408739
24TRPM71.43132967
25DYRK31.39770404
26PBK1.30948593
27MAPKAPK31.21367092
28LATS11.20977837
29RPS6KA41.13905001
30TESK11.08285479
31STK38L1.07511612
32ICK1.06642061
33FRK1.06389261
34PDGFRB1.05973252
35MELK1.00442754
36SGK21.00007539
37PRKCE0.93574295
38CAMK1D0.91716497
39CDK80.91047907
40TIE10.87488440
41IRAK30.85484637
42CSNK1A1L0.83900595
43PAK20.83897788
44SIK10.81373354
45MAP3K70.80606044
46EEF2K0.80599645
47SGK4940.80412605
48SGK2230.80412605
49PHKG10.79964494
50PHKG20.79964494
51LIMK10.75511350
52MARK20.71340040
53NEK90.70588095
54BLK0.70180796
55CAMK2B0.69155106
56SGK30.68267839
57BMPR1B0.67890970
58EPHB20.66983111
59WNK10.66860703
60MAP3K50.64740788
61CDK50.61892677
62CCNB10.60229926
63CHUK0.58706974
64CAMK2D0.58193248
65PTK2B0.57673780
66SRPK10.56230927
67TLK10.53940523
68JAK10.53920626
69RET0.53117120
70MTOR0.51422975
71ERBB30.50302193
72MAPK100.46089236
73TGFBR20.45861118
74BMX0.44312095
75MAPK90.43382700
76TTN0.41653640
77CAMK1G0.41414094
78OBSCN0.40489301
79EPHB10.40177314
80ROCK10.38851288
81MAPK110.35800671
82NEK20.35193487
83RPS6KA20.34366388
84OXSR10.34243162
85INSRR0.32201338
86CDC70.32108065
87BRD40.31633156
88SGK10.31611860
89CAMK2G0.31289162
90DYRK1A0.31177263
91MAPK10.30981467
92PKN10.28624409
93CAMK40.28365017
94PRKCZ0.27585069
95ABL10.27373255
96MAPK40.24341274
97STK240.23631831
98STK390.22920443
99PRPF4B0.22354524
100FGFR30.22315640

Predicted pathways (KEGG)

RankGene SetZ-score
1Taste transduction_Homo sapiens_hsa047422.61910669
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.61624059
3Adherens junction_Homo sapiens_hsa045202.34124801
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.28303592
5Glutamatergic synapse_Homo sapiens_hsa047242.23657098
6ECM-receptor interaction_Homo sapiens_hsa045122.15581701
7Nicotine addiction_Homo sapiens_hsa050332.06797034
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.92332914
9Fatty acid biosynthesis_Homo sapiens_hsa000611.86439144
10Circadian rhythm_Homo sapiens_hsa047101.79512610
11Focal adhesion_Homo sapiens_hsa045101.78396607
12Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.73920480
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.68279510
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.64990696
15Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64712015
16Synaptic vesicle cycle_Homo sapiens_hsa047211.63848796
17Dilated cardiomyopathy_Homo sapiens_hsa054141.58861031
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.56437169
19Small cell lung cancer_Homo sapiens_hsa052221.53820089
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.45868926
21Lysine degradation_Homo sapiens_hsa003101.37810314
22Axon guidance_Homo sapiens_hsa043601.32164343
23Pancreatic cancer_Homo sapiens_hsa052121.31156636
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.28737725
25Type II diabetes mellitus_Homo sapiens_hsa049301.25653937
26Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.20928593
27GnRH signaling pathway_Homo sapiens_hsa049121.18753992
28Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17331821
29Viral myocarditis_Homo sapiens_hsa054161.14770500
30Salivary secretion_Homo sapiens_hsa049701.12827576
31Choline metabolism in cancer_Homo sapiens_hsa052311.06815527
32Hippo signaling pathway_Homo sapiens_hsa043901.03753581
33TGF-beta signaling pathway_Homo sapiens_hsa043501.02923213
34Toxoplasmosis_Homo sapiens_hsa051451.01751971
35AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.00686677
36Colorectal cancer_Homo sapiens_hsa052100.97138733
37Long-term depression_Homo sapiens_hsa047300.95929492
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94629155
39Thyroid hormone synthesis_Homo sapiens_hsa049180.94256052
40Insulin resistance_Homo sapiens_hsa049310.93350476
41Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90764744
42Renal cell carcinoma_Homo sapiens_hsa052110.90724545
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89778597
44Dopaminergic synapse_Homo sapiens_hsa047280.89100650
45Phospholipase D signaling pathway_Homo sapiens_hsa040720.87583622
46Ether lipid metabolism_Homo sapiens_hsa005650.85594926
47Proteoglycans in cancer_Homo sapiens_hsa052050.85130505
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.84914096
49NF-kappa B signaling pathway_Homo sapiens_hsa040640.84460087
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84422137
51Ras signaling pathway_Homo sapiens_hsa040140.84057402
52Gap junction_Homo sapiens_hsa045400.82055136
53Dorso-ventral axis formation_Homo sapiens_hsa043200.79472706
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77603568
55Intestinal immune network for IgA production_Homo sapiens_hsa046720.77565533
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73817087
57AMPK signaling pathway_Homo sapiens_hsa041520.73746836
58Aldosterone synthesis and secretion_Homo sapiens_hsa049250.73395456
59Cholinergic synapse_Homo sapiens_hsa047250.72948946
60TNF signaling pathway_Homo sapiens_hsa046680.71220631
61Long-term potentiation_Homo sapiens_hsa047200.70116446
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.69644702
63Pathways in cancer_Homo sapiens_hsa052000.69221624
64PI3K-Akt signaling pathway_Homo sapiens_hsa041510.69144388
65Starch and sucrose metabolism_Homo sapiens_hsa005000.68160596
66Endocytosis_Homo sapiens_hsa041440.67150379
67MAPK signaling pathway_Homo sapiens_hsa040100.66881901
68ErbB signaling pathway_Homo sapiens_hsa040120.65520069
69Inositol phosphate metabolism_Homo sapiens_hsa005620.65512735
70Alcoholism_Homo sapiens_hsa050340.65217285
71mTOR signaling pathway_Homo sapiens_hsa041500.63916215
72Salmonella infection_Homo sapiens_hsa051320.63619775
73GABAergic synapse_Homo sapiens_hsa047270.62810394
74MicroRNAs in cancer_Homo sapiens_hsa052060.62062894
75Viral carcinogenesis_Homo sapiens_hsa052030.61904724
76Tight junction_Homo sapiens_hsa045300.60375964
77Apoptosis_Homo sapiens_hsa042100.58516731
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57762168
79Systemic lupus erythematosus_Homo sapiens_hsa053220.57211607
80Vibrio cholerae infection_Homo sapiens_hsa051100.54654166
81FoxO signaling pathway_Homo sapiens_hsa040680.53793656
82Estrogen signaling pathway_Homo sapiens_hsa049150.53509423
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51505386
84Basal transcription factors_Homo sapiens_hsa030220.50907713
85Renin secretion_Homo sapiens_hsa049240.50819832
86Hepatitis B_Homo sapiens_hsa051610.50761538
87Amphetamine addiction_Homo sapiens_hsa050310.49651905
88Shigellosis_Homo sapiens_hsa051310.49454242
89Fanconi anemia pathway_Homo sapiens_hsa034600.49195867
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.48635337
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48633043
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46967030
93Amoebiasis_Homo sapiens_hsa051460.46940582
94ABC transporters_Homo sapiens_hsa020100.46889364
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46614393
96Cocaine addiction_Homo sapiens_hsa050300.45945680
97Complement and coagulation cascades_Homo sapiens_hsa046100.45562066
98HIF-1 signaling pathway_Homo sapiens_hsa040660.45526491
99Circadian entrainment_Homo sapiens_hsa047130.45524847
100Prolactin signaling pathway_Homo sapiens_hsa049170.45425396

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