ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	substrate-independent telencephalic tangential migration (GO:0021826)	7.58819167
2	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	7.58819167
3	peristalsis (GO:0030432)	6.59940354
4	regulation of mitotic spindle organization (GO:0060236)	6.46740254
5	neuron remodeling (GO:0016322)	6.20550476
6	head development (GO:0060322)	6.15390008
7	lateral sprouting from an epithelium (GO:0060601)	5.00629766
8	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	4.86259237
9	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	4.86259237
10	ephrin receptor signaling pathway (GO:0048013)	4.64477632
11	negative regulation of cAMP-mediated signaling (GO:0043951)	4.58003277
12	dopamine transport (GO:0015872)	4.57606427
13	maternal behavior (GO:0042711)	4.53510412
14	hindbrain development (GO:0030902)	4.47455631
15	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	4.44505335
16	regulation of transforming growth factor beta2 production (GO:0032909)	4.43971253
17	behavioral response to cocaine (GO:0048148)	4.36831074
18	phasic smooth muscle contraction (GO:0014821)	4.25090737
19	regulation of spindle organization (GO:0090224)	4.18739186
20	parental behavior (GO:0060746)	4.15974754
21	cell proliferation in forebrain (GO:0021846)	4.07147859
22	tryptophan metabolic process (GO:0006568)	4.03281067
23	sulfation (GO:0051923)	4.01590769
24	lens fiber cell development (GO:0070307)	3.94623917
25	sex differentiation (GO:0007548)	3.91486463
26	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	3.89485301
27	sodium-independent organic anion transport (GO:0043252)	3.76487802
28	substrate-dependent cell migration (GO:0006929)	3.74030304
29	adult walking behavior (GO:0007628)	3.72575068
30	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.72514969
31	regulation of translation, ncRNA-mediated (GO:0045974)	3.72514969
32	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.72514969
33	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199	3.72182615
34	pyrimidine nucleobase catabolic process (GO:0006208)	3.68632846
35	transmission of nerve impulse (GO:0019226)	3.63372953
36	regulation of neurotransmitter uptake (GO:0051580)	3.62849671
37	synaptic transmission, dopaminergic (GO:0001963)	3.60277915
38	neuronal stem cell maintenance (GO:0097150)	3.52613267
39	negative regulation of neurotransmitter secretion (GO:0046929)	3.49744022
40	detection of molecule of bacterial origin (GO:0032490)	3.46776679
41	S-adenosylmethionine metabolic process (GO:0046500)	3.46723764
42	regulation of non-canonical Wnt signaling pathway (GO:2000050)	3.45935122
43	positive regulation of receptor activity (GO:2000273)	3.44534309
44	pituitary gland development (GO:0021983)	3.44444051
45	indole-containing compound catabolic process (GO:0042436)	3.42019705
46	indolalkylamine catabolic process (GO:0046218)	3.42019705
47	tryptophan catabolic process (GO:0006569)	3.42019705
48	somatic stem cell maintenance (GO:0035019)	3.40898809
49	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	3.40543476
50	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	3.40543476
51	neural tube formation (GO:0001841)	3.39979210
52	striatum development (GO:0021756)	3.38206456
53	positive regulation of triglyceride biosynthetic process (GO:0010867)	3.35472057
54	positive regulation of RNA splicing (GO:0033120)	3.34507543
55	generation of neurons (GO:0048699)	3.33945662
56	neuron maturation (GO:0042551)	3.33365833
57	positive regulation of T cell differentiation in thymus (GO:0033089)	3.27328821
58	asymmetric protein localization (GO:0008105)	3.22652020
59	dentate gyrus development (GO:0021542)	3.21565482
60	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	3.21054334
61	flavonoid metabolic process (GO:0009812)	3.20042211
62	stem cell development (GO:0048864)	3.17679486
63	neuroblast proliferation (GO:0007405)	3.16068026
64	somatic stem cell division (GO:0048103)	3.09395222
65	prepulse inhibition (GO:0060134)	3.07068031
66	organ formation (GO:0048645)	3.04503091
67	centriole replication (GO:0007099)	3.04147349
68	neural precursor cell proliferation (GO:0061351)	3.03545372
69	nephron tubule morphogenesis (GO:0072078)	3.01529755
70	nephron epithelium morphogenesis (GO:0072088)	3.01529755
71	cellular response to interferon-alpha (GO:0035457)	2.99063079
72	catecholamine transport (GO:0051937)	2.98469172
73	nucleobase catabolic process (GO:0046113)	2.97302852
74	regulation of oligodendrocyte differentiation (GO:0048713)	2.95105462
75	DNA double-strand break processing (GO:0000729)	2.94482064
76	negative regulation of neurotransmitter transport (GO:0051589)	2.93225599
77	mating behavior (GO:0007617)	2.88634641
78	indolalkylamine metabolic process (GO:0006586)	2.85856823
79	astrocyte development (GO:0014002)	2.85544113
80	central nervous system neuron axonogenesis (GO:0021955)	2.83686952
81	regulation of cardioblast proliferation (GO:0003264)	2.80704414
82	regulation of secondary heart field cardioblast proliferation (GO:0003266)	2.80704414
83	forebrain neuron differentiation (GO:0021879)	2.78682292
84	protein K11-linked deubiquitination (GO:0035871)	2.78350276
85	regulation of triglyceride biosynthetic process (GO:0010866)	2.77805248
86	left/right axis specification (GO:0070986)	2.77459269
87	positive regulation of neuroblast proliferation (GO:0002052)	2.75274285
88	nonmotile primary cilium assembly (GO:0035058)	2.74837644
89	positive regulation of developmental pigmentation (GO:0048087)	2.71834329
90	mRNA modification (GO:0016556)	2.70295082
91	cell wall macromolecule catabolic process (GO:0016998)	2.67143836
92	outer ear morphogenesis (GO:0042473)	2.65836116
93	maturation of 5.8S rRNA (GO:0000460)	2.65123084
94	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.64814495
95	response to pheromone (GO:0019236)	2.64296704
96	behavioral defense response (GO:0002209)	2.62403187
97	behavioral fear response (GO:0001662)	2.62403187
98	regulation of heat generation (GO:0031650)	2.59414422
99	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.58944232
100	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.58944232

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.59171247
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.23305978
3	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.02532187
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.99074933
5	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.94832200
6	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.94160658
7	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.89781137
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.67880120
9	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.45286286
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.34693007
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.19174596
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.14163751
13	SUZ12_27294783_Chip-Seq_NPCs_Mouse	2.08068507
14	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	2.03218961
15	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.91477809
16	FUS_26573619_Chip-Seq_HEK293_Human	1.90788749
17	P300_19829295_ChIP-Seq_ESCs_Human	1.89776897
18	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.87885835
19	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.84298876
20	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.81992220
21	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.78960505
22	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.78635491
23	SMAD4_21799915_ChIP-Seq_A2780_Human	1.76323278
24	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.75903703
25	CBP_20019798_ChIP-Seq_JUKART_Human	1.75903703
26	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.74896878
27	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.74551848
28	AHR_22903824_ChIP-Seq_MCF-7_Human	1.74239089
29	IGF1R_20145208_ChIP-Seq_DFB_Human	1.74051097
30	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.72115584
31	EWS_26573619_Chip-Seq_HEK293_Human	1.69785330
32	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.68817500
33	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.68626120
34	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.66074021
35	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.65838389
36	P53_22387025_ChIP-Seq_ESCs_Mouse	1.65380795
37	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.64553833
38	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.62226946
39	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.61669339
40	BCAT_22108803_ChIP-Seq_LS180_Human	1.58240699
41	STAT3_23295773_ChIP-Seq_U87_Human	1.57388134
42	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.57221193
43	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.54538775
44	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.52979590
45	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.51967258
46	P300_18555785_Chip-Seq_ESCs_Mouse	1.51670585
47	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.50724944
48	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.49119413
49	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.48998346
50	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.47248090
51	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.47093945
52	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.43077666
53	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.41956278
54	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.41533976
55	RUNX2_22187159_ChIP-Seq_PCA_Human	1.41085645
56	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.39976829
57	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.36977551
58	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.36458871
59	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.35306382
60	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.35306382
61	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.33777590
62	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.33255692
63	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.32083708
64	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.29793792
65	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.28668618
66	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.27620215
67	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.27441214
68	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.27380981
69	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.27124918
70	TCF4_22108803_ChIP-Seq_LS180_Human	1.27084549
71	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.26552483
72	PU1_27457419_Chip-Seq_LIVER_Mouse	1.24066633
73	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.22739059
74	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.22089570
75	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.21252978
76	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.20676636
77	SOX2_19829295_ChIP-Seq_ESCs_Human	1.20498487
78	NANOG_19829295_ChIP-Seq_ESCs_Human	1.20498487
79	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.19154029
80	KLF4_18555785_Chip-Seq_ESCs_Mouse	1.18554645
81	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.17765637
82	RNF2_27304074_Chip-Seq_NSC_Mouse	1.17674016
83	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.16855582
84	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.16797152
85	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.16797152
86	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15087659
87	TCF4_23295773_ChIP-Seq_U87_Human	1.14966381
88	AR_25329375_ChIP-Seq_VCAP_Human	1.13965712
89	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.12156158
90	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.09130201
91	RUNX1_27457419_Chip-Seq_LIVER_Mouse	1.09019813
92	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.08732117
93	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.08185280
94	ER_23166858_ChIP-Seq_MCF-7_Human	1.08116050
95	CDX2_22108803_ChIP-Seq_LS180_Human	1.07736517
96	ZFX_18555785_Chip-Seq_ESCs_Mouse	1.07669611
97	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.07112432
98	JUN_21703547_ChIP-Seq_K562_Human	1.06939008
99	CTCF_18555785_Chip-Seq_ESCs_Mouse	1.06719867
100	VDR_22108803_ChIP-Seq_LS180_Human	1.04797223

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.78431030
2	MP0005423_abnormal_somatic_nervous	3.57088623
3	MP0004147_increased_porphyrin_level	3.30008605
4	MP0005171_absent_coat_pigmentation	2.98620405
5	MP0002160_abnormal_reproductive_system	2.88729737
6	MP0001188_hyperpigmentation	2.67635486
7	MP0001919_abnormal_reproductive_system	2.50598736
8	MP0001727_abnormal_embryo_implantation	2.28685816
9	MP0003183_abnormal_peptide_metabolism	2.21488400
10	MP0003880_abnormal_central_pattern	11.1287197
11	MP0002653_abnormal_ependyma_morphology	1.86511751
12	MP0002751_abnormal_autonomic_nervous	1.82881975
13	MP0009697_abnormal_copulation	1.77102416
14	MP0002234_abnormal_pharynx_morphology	1.75063440
15	MP0000569_abnormal_digit_pigmentation	1.71343122
16	MP0003938_abnormal_ear_development	1.71268448
17	MP0002277_abnormal_respiratory_mucosa	1.69810809
18	MP0002163_abnormal_gland_morphology	1.65833304
19	MP0000613_abnormal_salivary_gland	1.63158525
20	MP0005389_reproductive_system_phenotype	1.57298839
21	MP0000778_abnormal_nervous_system	1.54498475
22	MP0005645_abnormal_hypothalamus_physiol	1.54345234
23	MP0000955_abnormal_spinal_cord	1.52178685
24	MP0000049_abnormal_middle_ear	1.51626749
25	MP0000631_abnormal_neuroendocrine_gland	1.50223282
26	MP0003136_yellow_coat_color	1.44063701
27	MP0002837_dystrophic_cardiac_calcinosis	1.39109445
28	MP0003195_calcinosis	1.35315151
29	MP0009250_abnormal_appendicular_skeleto	1.32871272
30	MP0002638_abnormal_pupillary_reflex	1.30607387
31	MP0005551_abnormal_eye_electrophysiolog	1.26776021
32	MP0005386_behavior/neurological_phenoty	1.25782350
33	MP0004924_abnormal_behavior	1.25782350
34	MP0006276_abnormal_autonomic_nervous	1.22965141
35	MP0003755_abnormal_palate_morphology	1.21705308
36	MP0002233_abnormal_nose_morphology	1.20698643
37	MP0000026_abnormal_inner_ear	1.17874409
38	MP0002098_abnormal_vibrissa_morphology	1.15212612
39	MP0003011_delayed_dark_adaptation	1.12239416
40	MP0005075_abnormal_melanosome_morpholog	1.10171275
41	MP0001286_abnormal_eye_development	1.10085959
42	MP0002928_abnormal_bile_duct	1.08891761
43	MP0003656_abnormal_erythrocyte_physiolo	1.07938515
44	MP0001873_stomach_inflammation	1.07907420
45	MP0004885_abnormal_endolymph	1.07555582
46	MP0003172_abnormal_lysosome_physiology	1.06135002
47	MP0002272_abnormal_nervous_system	1.05129958
48	MP0008789_abnormal_olfactory_epithelium	1.04971674
49	MP0002109_abnormal_limb_morphology	1.04256748
50	MP0003936_abnormal_reproductive_system	1.03768112
51	MP0006292_abnormal_olfactory_placode	1.03376592
52	MP0008057_abnormal_DNA_replication	1.00860623
53	MP0003828_pulmonary_edema	1.00352262
54	MP0001486_abnormal_startle_reflex	0.98234124
55	MP0002282_abnormal_trachea_morphology	0.95052522
56	MP0001293_anophthalmia	0.93538042
57	MP0000427_abnormal_hair_cycle	0.92825485
58	MP0010352_gastrointestinal_tract_polyps	0.92817231
59	MP0002108_abnormal_muscle_morphology	0.92442767
60	MP0003950_abnormal_plasma_membrane	0.91814188
61	MP0003045_fibrosis	0.91329556
62	MP0006072_abnormal_retinal_apoptosis	0.89353369
63	MP0003935_abnormal_craniofacial_develop	0.88870694
64	MP0005174_abnormal_tail_pigmentation	0.84988438
65	MP0002115_abnormal_skeleton_extremities	0.84524572
66	MP0004142_abnormal_muscle_tone	0.84077521
67	MP0002184_abnormal_innervation	0.83362525
68	MP0005379_endocrine/exocrine_gland_phen	0.82075664
69	MP0003937_abnormal_limbs/digits/tail_de	0.80987534
70	MP0004133_heterotaxia	0.80282049
71	MP0009046_muscle_twitch	0.78727166
72	MP0009384_cardiac_valve_regurgitation	0.78439820
73	MP0003724_increased_susceptibility_to	0.73150377
74	MP0002557_abnormal_social/conspecific_i	0.71406894
75	MP0000516_abnormal_urinary_system	0.70421808
76	MP0005367_renal/urinary_system_phenotyp	0.70421808
77	MP0005187_abnormal_penis_morphology	0.68135235
78	MP0000372_irregular_coat_pigmentation	0.67294301
79	MP0005253_abnormal_eye_physiology	0.66845286
80	MP0000627_abnormal_mammary_gland	0.65407446
81	MP0003861_abnormal_nervous_system	0.64256682
82	MP0003121_genomic_imprinting	0.64177586
83	MP0002882_abnormal_neuron_morphology	0.63942550
84	MP0002249_abnormal_larynx_morphology	0.63675904
85	MP0000647_abnormal_sebaceous_gland	0.63232738
86	MP0002697_abnormal_eye_size	0.62947743
87	MP0000015_abnormal_ear_pigmentation	0.61987713
88	MP0000432_abnormal_head_morphology	0.61934552
89	MP0005248_abnormal_Harderian_gland	0.61775951
90	MP0003698_abnormal_male_reproductive	0.61520578
91	MP0005164_abnormal_response_to	0.61493821
92	MP0002152_abnormal_brain_morphology	0.60957098
93	MP0003252_abnormal_bile_duct	0.60610359
94	MP0000470_abnormal_stomach_morphology	0.60487496
95	MP0004215_abnormal_myocardial_fiber	0.60458844
96	MP0002938_white_spotting	0.59767570
97	MP0002177_abnormal_outer_ear	0.58653133
98	MP0000383_abnormal_hair_follicle	0.58259684
99	MP0009745_abnormal_behavioral_response	0.57938079
100	MP0005508_abnormal_skeleton_morphology	0.56052338

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperinsulinemic hypoglycemia (HP:0000825)	5.98287372
2	Broad ribs (HP:0000885)	5.23069718
3	Adactyly (HP:0009776)	5.04021841
4	Hypoplastic pelvis (HP:0008839)	4.82457353
5	Split foot (HP:0001839)	4.71326187
6	Oligodactyly (hands) (HP:0001180)	4.68292433
7	Fibular aplasia (HP:0002990)	4.51111523
8	Action tremor (HP:0002345)	4.50893303
9	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	3.94963351
10	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	3.89426779
11	Gonadotropin excess (HP:0000837)	3.82242509
12	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	3.49467471
13	Molar tooth sign on MRI (HP:0002419)	3.21936900
14	Abnormality of midbrain morphology (HP:0002418)	3.21936900
15	Resting tremor (HP:0002322)	3.16367194
16	Febrile seizures (HP:0002373)	3.13203824
17	Hypoplastic iliac wings (HP:0002866)	3.10375123
18	Humeroradial synostosis (HP:0003041)	3.04925026
19	Synostosis involving the elbow (HP:0003938)	3.04925026
20	Aplasia/hypoplasia of the uterus (HP:0008684)	3.03831771
21	Oligodactyly (HP:0012165)	2.95087981
22	Lissencephaly (HP:0001339)	2.94931282
23	Aplasia/Hypoplasia of the 5th finger (HP:0006262)	2.75919927
24	Short foot (HP:0001773)	2.74810700
25	Abnormality of the pubic bones (HP:0003172)	2.65063714
26	Partial agenesis of the corpus callosum (HP:0001338)	2.64690505
27	Vertebral arch anomaly (HP:0008438)	2.59949588
28	Menstrual irregularities (HP:0000858)	2.59431073
29	Papilledema (HP:0001085)	2.56772211
30	Inappropriate behavior (HP:0000719)	2.55418352
31	Pachygyria (HP:0001302)	2.54897414
32	Spontaneous hematomas (HP:0007420)	2.54781432
33	Broad alveolar ridges (HP:0000187)	2.49711755
34	Congenital stationary night blindness (HP:0007642)	2.47904404
35	Absent speech (HP:0001344)	2.46086225
36	Submucous cleft hard palate (HP:0000176)	2.44918682
37	Tented upper lip vermilion (HP:0010804)	2.42626551
38	Protruding tongue (HP:0010808)	2.40886626
39	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.40003049
40	Nephrogenic diabetes insipidus (HP:0009806)	2.38119291
41	J-shaped sella turcica (HP:0002680)	2.36749716
42	Aplasia/Hypoplasia of the clavicles (HP:0006710)	2.36633163
43	Mask-like facies (HP:0000298)	2.36527414
44	Hyperventilation (HP:0002883)	2.35405915
45	Hypothermia (HP:0002045)	2.34678429
46	Hematochezia (HP:0002573)	2.32223926
47	Drooling (HP:0002307)	2.31157072
48	Abnormality of chromosome segregation (HP:0002916)	2.30883418
49	Anophthalmia (HP:0000528)	2.27507595
50	Diastasis recti (HP:0001540)	2.27201096
51	Barrel-shaped chest (HP:0001552)	2.26236094
52	Abnormal number of incisors (HP:0011064)	2.25865455
53	Congenital primary aphakia (HP:0007707)	2.24807413
54	Skull defect (HP:0001362)	2.24072476
55	Postaxial hand polydactyly (HP:0001162)	2.23013070
56	Aplasia/Hypoplasia of the fibula (HP:0006492)	2.20224480
57	Abnormal finger flexion creases (HP:0006143)	2.19826368
58	Gait imbalance (HP:0002141)	2.18592739
59	Fair hair (HP:0002286)	2.15681050
60	Exertional dyspnea (HP:0002875)	2.15214403
61	Tarsal synostosis (HP:0008368)	2.13699815
62	Medial flaring of the eyebrow (HP:0010747)	2.13181981
63	Albinism (HP:0001022)	2.12884970
64	Abnormality of secondary sexual hair (HP:0009888)	2.12231656
65	Abnormality of the axillary hair (HP:0100134)	2.12231656
66	Chronic hepatic failure (HP:0100626)	2.10947835
67	Excessive salivation (HP:0003781)	2.10444053
68	Abnormality of the wing of the ilium (HP:0011867)	2.08222291
69	Narrow palate (HP:0000189)	2.08067176
70	Exotropia (HP:0000577)	2.07628884
71	Hypoplastic nipples (HP:0002557)	2.07579787
72	Hemivertebrae (HP:0002937)	2.05465558
73	Nephronophthisis (HP:0000090)	2.04454923
74	Intellectual disability, moderate (HP:0002342)	2.02842796
75	Progressive inability to walk (HP:0002505)	2.00561178
76	Synostosis involving bones of the lower limbs (HP:0009138)	1.99239242
77	Synostosis involving bones of the feet (HP:0009140)	1.99239242
78	Delayed puberty (HP:0000823)	1.95937369
79	Disinhibition (HP:0000734)	1.95416835
80	Macroorchidism (HP:0000053)	1.88808546
81	Selective tooth agenesis (HP:0001592)	1.88244186
82	Absent eyebrow (HP:0002223)	1.87639887
83	Abnormality of the renal medulla (HP:0100957)	1.84595134
84	Thickened helices (HP:0000391)	1.83663350
85	Shawl scrotum (HP:0000049)	1.82064245
86	Curly hair (HP:0002212)	1.81725792
87	Neoplasm of the tracheobronchial system (HP:0100552)	1.81509957
88	Meningocele (HP:0002435)	1.80307289
89	Radial bowing (HP:0002986)	1.79006694
90	Decreased skull ossification (HP:0004331)	1.76629218
91	Intellectual disability, profound (HP:0002187)	1.76523377
92	Hypoplastic ilia (HP:0000946)	1.76380356
93	Cavernous hemangioma (HP:0001048)	1.76214799
94	Poor eye contact (HP:0000817)	1.75771413
95	Optic nerve hypoplasia (HP:0000609)	1.75138608
96	Genital tract atresia (HP:0001827)	1.72800675
97	Growth hormone deficiency (HP:0000824)	1.72553686
98	Alveolar cell carcinoma (HP:0006519)	1.71429659
99	Abnormality of ocular smooth pursuit (HP:0000617)	1.71133841
100	Heterotopia (HP:0002282)	1.69866409

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TNIK	8.58815404
2	AKT3	5.63060013
3	INSRR	4.60945274
4	PNCK	4.22054179
5	CDK9	3.89864307
6	NLK	3.28283009
7	GRK1	2.79069772
8	EPHA3	2.43250535
9	MAP4K2	2.34069724
10	FRK	1.85678762
11	SGK2	1.56534100
12	TTK	1.50620469
13	EIF2AK1	1.48570646
14	WEE1	1.48370365
15	LATS1	1.35399364
16	DYRK2	1.34947640
17	DYRK3	1.14734475
18	IRAK1	1.14652673
19	BCR	1.14221656
20	STK38L	1.14065727
21	NUAK1	1.09311900
22	MAPK13	1.05740831
23	VRK1	1.04269447
24	ERBB3	1.02583564
25	IRAK4	1.01276860
26	EPHB2	0.98820772
27	SGK3	0.97542162
28	SGK223	0.96485353
29	SGK494	0.96485353
30	WNK3	0.93244422
31	PRKCE	0.93243538
32	PLK2	0.92145561
33	BMPR1B	0.90241199
34	PLK4	0.90061871
35	BRAF	0.89953863
36	ZAP70	0.83097568
37	EPHA4	0.79768503
38	CDK19	0.76005867
39	CDK8	0.74948899
40	CDC7	0.73763059
41	MAP3K4	0.71369240
42	EIF2AK3	0.71017769
43	BLK	0.62740553
44	BRD4	0.61761322
45	CAMK4	0.61302868
46	BMPR2	0.59779480
47	HIPK2	0.59254004
48	RPS6KA4	0.57638715
49	YES1	0.56721790
50	PIK3CG	0.56142407
51	CAMK1G	0.54601982
52	MELK	0.51775620
53	FER	0.51455749
54	UHMK1	0.50307977
55	DYRK1A	0.49183934
56	MATK	0.48644484
57	PRKCG	0.48639469
58	PRKD3	0.48008912
59	OXSR1	0.46040783
60	MINK1	0.43529327
61	CHUK	0.42475841
62	IRAK2	0.42217303
63	MAP2K4	0.41931657
64	PLK3	0.40560668
65	PTK2B	0.39031204
66	PAK3	0.37478218
67	PRKG1	0.37288378
68	MARK1	0.35733552
69	BRSK2	0.35501411
70	STK38	0.34613054
71	CASK	0.33832493
72	IKBKE	0.32390794
73	PBK	0.31877682
74	MAP2K7	0.31244140
75	EPHB1	0.29936438
76	STK11	0.28203143
77	CSNK1A1L	0.27127982
78	OBSCN	0.26520474
79	MAP2K3	0.26376509
80	PAK6	0.25897950
81	RPS6KB1	0.24358073
82	CSNK1G2	0.23903952
83	MAPK1	0.23407391
84	TRIM28	0.22932651
85	GSK3A	0.22155876
86	MAPK3	0.21243877
87	EGFR	0.19916981
88	ADRBK2	0.19857072
89	ERBB2	0.19462386
90	MAP2K2	0.19107089
91	MKNK2	0.18828228
92	MAPK15	0.17743399
93	CDK5	0.17168124
94	EIF2AK2	0.16631156
95	SGK1	0.16171420
96	CAMK2B	0.15792775
97	CAMK2A	0.14786269
98	TAOK1	0.14563315
99	TGFBR1	0.13625023
100	ADRBK1	0.13352068

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	4.03509286
2	Basal cell carcinoma_Homo sapiens_hsa05217	3.35200731
3	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	3.30339922
4	Cocaine addiction_Homo sapiens_hsa05030	2.72114273
5	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.33507311
6	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	2.02225639
7	Protein export_Homo sapiens_hsa03060	2.00245559
8	Nicotine addiction_Homo sapiens_hsa05033	1.97745832
9	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.85360493
10	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.84299379
11	Selenocompound metabolism_Homo sapiens_hsa00450	1.81191112
12	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.70361564
13	Hippo signaling pathway_Homo sapiens_hsa04390	1.66670197
14	Taste transduction_Homo sapiens_hsa04742	1.66623575
15	Lysine degradation_Homo sapiens_hsa00310	1.56551377
16	Prostate cancer_Homo sapiens_hsa05215	1.56375712
17	Alcoholism_Homo sapiens_hsa05034	1.49310500
18	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.46151210
19	Amphetamine addiction_Homo sapiens_hsa05031	1.45982748
20	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.42250021
21	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.41977316
22	RNA degradation_Homo sapiens_hsa03018	1.38824391
23	Melanogenesis_Homo sapiens_hsa04916	1.35825022
24	Insulin secretion_Homo sapiens_hsa04911	1.34911320
25	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.32702242
26	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.32461395
27	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.27905486
28	Ether lipid metabolism_Homo sapiens_hsa00565	1.26784158
29	Phototransduction_Homo sapiens_hsa04744	1.26287085
30	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.25829286
31	Thyroid cancer_Homo sapiens_hsa05216	1.25368990
32	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.22867705
33	FoxO signaling pathway_Homo sapiens_hsa04068	1.17486787
34	Morphine addiction_Homo sapiens_hsa05032	1.17135849
35	Dopaminergic synapse_Homo sapiens_hsa04728	1.14774386
36	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.14243349
37	Nitrogen metabolism_Homo sapiens_hsa00910	1.13965940
38	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.13043783
39	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.10612632
40	Axon guidance_Homo sapiens_hsa04360	1.09474359
41	Tight junction_Homo sapiens_hsa04530	1.00789776
42	Wnt signaling pathway_Homo sapiens_hsa04310	0.89981237
43	Circadian rhythm_Homo sapiens_hsa04710	0.89608446
44	cAMP signaling pathway_Homo sapiens_hsa04024	0.88789278
45	beta-Alanine metabolism_Homo sapiens_hsa00410	0.87605696
46	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.86010685
47	Basal transcription factors_Homo sapiens_hsa03022	0.85782443
48	Calcium signaling pathway_Homo sapiens_hsa04020	0.85498879
49	GABAergic synapse_Homo sapiens_hsa04727	0.82594456
50	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.81538319
51	Collecting duct acid secretion_Homo sapiens_hsa04966	0.81292468
52	Butanoate metabolism_Homo sapiens_hsa00650	0.81219865
53	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.77698260
54	TNF signaling pathway_Homo sapiens_hsa04668	0.75661214
55	Viral carcinogenesis_Homo sapiens_hsa05203	0.74186171
56	Linoleic acid metabolism_Homo sapiens_hsa00591	0.73726067
57	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.72653085
58	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.68942687
59	Colorectal cancer_Homo sapiens_hsa05210	0.67521221
60	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.67462529
61	Endometrial cancer_Homo sapiens_hsa05213	0.66434289
62	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.65924274
63	Estrogen signaling pathway_Homo sapiens_hsa04915	0.64764778
64	Tryptophan metabolism_Homo sapiens_hsa00380	0.62711333
65	Hepatitis C_Homo sapiens_hsa05160	0.61734370
66	Legionellosis_Homo sapiens_hsa05134	0.61244730
67	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.59964039
68	Olfactory transduction_Homo sapiens_hsa04740	0.58815491
69	AMPK signaling pathway_Homo sapiens_hsa04152	0.57289129
70	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.55598149
71	Steroid biosynthesis_Homo sapiens_hsa00100	0.54397025
72	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.53212520
73	Regulation of autophagy_Homo sapiens_hsa04140	0.52563369
74	Long-term depression_Homo sapiens_hsa04730	0.52512903
75	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.51916468
76	Fanconi anemia pathway_Homo sapiens_hsa03460	0.50386412
77	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.50282346
78	Type II diabetes mellitus_Homo sapiens_hsa04930	0.50018981
79	Ras signaling pathway_Homo sapiens_hsa04014	0.49136187
80	Chemical carcinogenesis_Homo sapiens_hsa05204	0.48264386
81	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.47715507
82	Retinol metabolism_Homo sapiens_hsa00830	0.46848942
83	Glutamatergic synapse_Homo sapiens_hsa04724	0.44444448
84	Mineral absorption_Homo sapiens_hsa04978	0.43376305
85	Renin secretion_Homo sapiens_hsa04924	0.43372809
86	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.41627163
87	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.41542226
88	Histidine metabolism_Homo sapiens_hsa00340	0.41415826
89	Hepatitis B_Homo sapiens_hsa05161	0.41373619
90	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.41170348
91	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.40651806
92	Tuberculosis_Homo sapiens_hsa05152	0.40623561
93	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.40355314
94	Rap1 signaling pathway_Homo sapiens_hsa04015	0.39449296
95	RNA transport_Homo sapiens_hsa03013	0.38661489
96	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.37776000
97	MicroRNAs in cancer_Homo sapiens_hsa05206	0.37497184
98	Glucagon signaling pathway_Homo sapiens_hsa04922	0.36998484
99	Pathways in cancer_Homo sapiens_hsa05200	0.36869699
100	Insulin resistance_Homo sapiens_hsa04931	0.36161687

BNIP3P40

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »