BNIP3P41

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1B cell receptor signaling pathway (GO:0050853)6.58458611
2rRNA catabolic process (GO:0016075)5.52501330
3regulation of telomere maintenance via telomerase (GO:0032210)5.20518474
4positive regulation of B cell differentiation (GO:0045579)5.03756635
5spermatid nucleus differentiation (GO:0007289)4.88187252
6regulation of memory T cell differentiation (GO:0043380)4.80257349
7mucosal-associated lymphoid tissue development (GO:0048537)4.71125734
8Peyers patch development (GO:0048541)4.71125734
9regulation of B cell receptor signaling pathway (GO:0050855)4.60724351
10DNA topological change (GO:0006265)4.58590881
11purinergic nucleotide receptor signaling pathway (GO:0035590)4.49901112
12positive regulation of gamma-delta T cell activation (GO:0046645)4.24688493
13positive thymic T cell selection (GO:0045059)4.14153859
14antigen processing and presentation of endogenous antigen (GO:0019883)4.01087982
15regulation of B cell differentiation (GO:0045577)3.99791782
16negative regulation of type 2 immune response (GO:0002829)3.93149038
17cytoplasmic mRNA processing body assembly (GO:0033962)3.91734801
18protoporphyrinogen IX biosynthetic process (GO:0006782)3.84989814
19seminiferous tubule development (GO:0072520)3.82479129
20regulation of B cell apoptotic process (GO:0002902)3.80240169
21negative regulation of multicellular organism growth (GO:0040015)3.77221266
22G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.76436276
23mitochondrial DNA replication (GO:0006264)3.73066268
24ribosome assembly (GO:0042255)3.72303922
25megakaryocyte development (GO:0035855)3.63136782
26single strand break repair (GO:0000012)3.59790688
27regulation of female gonad development (GO:2000194)3.56621769
28protein ADP-ribosylation (GO:0006471)3.55522065
29positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.52357341
30regulation of MHC class I biosynthetic process (GO:0045343)3.52044803
31histamine secretion (GO:0001821)3.51030082
32protoporphyrinogen IX metabolic process (GO:0046501)3.50812566
33replication fork processing (GO:0031297)3.50384170
34regulation of telomere maintenance (GO:0032204)3.40829521
35B cell proliferation (GO:0042100)3.35830256
36negative regulation of B cell apoptotic process (GO:0002903)3.34575042
37regulation of germinal center formation (GO:0002634)3.28504386
38maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.25761904
39regulation of gamma-delta T cell differentiation (GO:0045586)3.24335603
40regulation of Golgi to plasma membrane protein transport (GO:0042996)3.23601188
41mismatch repair (GO:0006298)3.21071130
42DNA ligation (GO:0006266)3.15881388
43deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.14834114
44somatic hypermutation of immunoglobulin genes (GO:0016446)3.14467860
45somatic diversification of immune receptors via somatic mutation (GO:0002566)3.14467860
46histone H4-K8 acetylation (GO:0043982)3.13016215
47histone H4-K5 acetylation (GO:0043981)3.13016215
48response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.04239184
49response to host immune response (GO:0052572)3.04239184
50regulation of establishment of cell polarity (GO:2000114)3.04021349
51RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.03454118
52B cell mediated immunity (GO:0019724)3.01040616
53purinergic receptor signaling pathway (GO:0035587)3.00595870
54positive regulation of granulocyte differentiation (GO:0030854)2.99170953
55histone H3-K9 methylation (GO:0051567)2.93600527
56definitive hemopoiesis (GO:0060216)2.89401699
57response to host (GO:0075136)2.89160056
58response to host defenses (GO:0052200)2.89160056
59response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.89160056
60replicative senescence (GO:0090399)2.87096098
61antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.85972306
62negative regulation of T cell differentiation (GO:0045581)2.85940450
63positive T cell selection (GO:0043368)2.85794216
64antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.85737444
65mature B cell differentiation (GO:0002335)2.82064098
66alternative mRNA splicing, via spliceosome (GO:0000380)2.82008663
67B cell activation (GO:0042113)2.79521902
68N-acetylglucosamine metabolic process (GO:0006044)2.79403204
69regulation of pigment cell differentiation (GO:0050932)2.79131983
70immunoglobulin mediated immune response (GO:0016064)2.79121610
71positive regulation of vasculogenesis (GO:2001214)2.78633693
72negative regulation of cell cycle G2/M phase transition (GO:1902750)2.77155694
73regulation of interferon-beta biosynthetic process (GO:0045357)2.76685681
74regulation of gamma-delta T cell activation (GO:0046643)2.76463288
75regulation of histone phosphorylation (GO:0033127)2.75401539
76negative regulation of DNA-dependent DNA replication (GO:2000104)2.74648680
77purine-containing compound salvage (GO:0043101)2.73673967
78purine deoxyribonucleotide catabolic process (GO:0009155)2.71874821
79ncRNA catabolic process (GO:0034661)2.70463830
80negative regulation of thymocyte apoptotic process (GO:0070244)2.69258848
81negative thymic T cell selection (GO:0045060)2.68410567
82regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.67404732
83DNA demethylation (GO:0080111)2.66140823
84regulation of histone H3-K9 methylation (GO:0051570)2.64555203
85histamine transport (GO:0051608)2.63472798
86iron-sulfur cluster assembly (GO:0016226)2.61497908
87metallo-sulfur cluster assembly (GO:0031163)2.61497908
88protein prenylation (GO:0018342)2.60869155
89prenylation (GO:0097354)2.60869155
90histone H3-K9 modification (GO:0061647)2.58724722
91mitochondrial RNA metabolic process (GO:0000959)2.58355261
92positive regulation of B cell activation (GO:0050871)2.57952440
93DNA dealkylation (GO:0035510)2.56928666
94negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.56729194
95L-fucose catabolic process (GO:0042355)2.54698279
96fucose catabolic process (GO:0019317)2.54698279
97L-fucose metabolic process (GO:0042354)2.54698279
98histone H4-K16 acetylation (GO:0043984)2.54298119
99preassembly of GPI anchor in ER membrane (GO:0016254)2.54170542
100regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.51087223

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.20532779
2E2F7_22180533_ChIP-Seq_HELA_Human5.88618655
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.88507211
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.59893760
5ZNF274_21170338_ChIP-Seq_K562_Hela2.65018494
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.62490176
7CIITA_25753668_ChIP-Seq_RAJI_Human2.61176826
8MYB_26560356_Chip-Seq_TH2_Human2.41972411
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.39185474
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.35931342
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.34835613
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.24084325
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.11235606
14VDR_22108803_ChIP-Seq_LS180_Human2.09990722
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.07662574
16MYC_22102868_ChIP-Seq_BL_Human2.06940361
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.03078274
18E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.00007785
19RUNX_20019798_ChIP-Seq_JUKART_Human1.99039043
20LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.95615462
21MYB_26560356_Chip-Seq_TH1_Human1.93866829
22SPI1_23547873_ChIP-Seq_NB4_Human1.90231132
23VDR_23849224_ChIP-Seq_CD4+_Human1.89467860
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.82599792
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.79984962
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79871134
27VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.73097077
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.68908667
29FOXP3_21729870_ChIP-Seq_TREG_Human1.68714996
30IGF1R_20145208_ChIP-Seq_DFB_Human1.61383100
31CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.59412015
32GATA3_27048872_Chip-Seq_THYMUS_Human1.54384643
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.53999480
34SCL_19346495_ChIP-Seq_HPC-7_Human1.53989592
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.53269527
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.49930832
37CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.49821335
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.47332130
39GATA3_26560356_Chip-Seq_TH2_Human1.44965817
40STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.40710127
41LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.35051268
42MYC_18940864_ChIP-ChIP_HL60_Human1.32639879
43TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.32439477
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28102743
45KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.27646958
46ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27557073
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25724584
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25286530
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.24147940
50TP53_22573176_ChIP-Seq_HFKS_Human1.24143609
51IRF8_27001747_Chip-Seq_BMDM_Mouse1.22235215
52MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.21048582
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20631267
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.19091055
55GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18736868
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.17589910
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17589910
58ETS1_20019798_ChIP-Seq_JURKAT_Human1.15486001
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15394852
60CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15133493
61RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.15041628
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.13343456
63SPI1_23127762_ChIP-Seq_K562_Human1.12915682
64AR_20517297_ChIP-Seq_VCAP_Human1.12472302
65GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.12224522
66ELK1_19687146_ChIP-ChIP_HELA_Human1.12008989
67EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11699924
68JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.11016595
69SMRT_27268052_Chip-Seq_Bcells_Human1.09588500
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09567038
71FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08146199
72TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.05536610
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.04944482
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03738659
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02976324
76P300_27268052_Chip-Seq_Bcells_Human1.02107184
77UTX_26944678_Chip-Seq_JUKART_Human1.01311941
78ELF1_20517297_ChIP-Seq_JURKAT_Human0.99264886
79GATA3_26560356_Chip-Seq_TH1_Human0.98855623
80FUS_26573619_Chip-Seq_HEK293_Human0.98721847
81GATA1_19941826_ChIP-Seq_K562_Human0.97714547
82GATA3_21878914_ChIP-Seq_MCF-7_Human0.95608444
83TP63_19390658_ChIP-ChIP_HaCaT_Human0.95556568
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95043798
85VDR_21846776_ChIP-Seq_THP-1_Human0.94550283
86IRF1_19129219_ChIP-ChIP_H3396_Human0.94337816
87MAF_26560356_Chip-Seq_TH1_Human0.94095569
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93728560
89CBP_20019798_ChIP-Seq_JUKART_Human0.93728560
90FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92376283
91EZH2_22144423_ChIP-Seq_EOC_Human0.91320526
92PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90552859
93GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90067399
94FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.88732859
95GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88483046
96SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88161385
97STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85724213
98KDM5A_27292631_Chip-Seq_BREAST_Human0.85448659
99VDR_24763502_ChIP-Seq_THP-1_Human0.85051711
100EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.82984781

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair3.92287744
2MP0001835_abnormal_antigen_presentation3.44343308
3MP0002396_abnormal_hematopoietic_system3.41958724
4MP0008877_abnormal_DNA_methylation2.84645119
5MP0001800_abnormal_humoral_immune2.80206173
6MP0002138_abnormal_hepatobiliary_system2.78017427
7MP0000685_abnormal_immune_system2.76090551
8MP0010094_abnormal_chromosome_stability2.70755229
9MP0001790_abnormal_immune_system2.65324926
10MP0005387_immune_system_phenotype2.65324926
11MP0009697_abnormal_copulation2.38073925
12MP0003252_abnormal_bile_duct2.37781742
13MP0005310_abnormal_salivary_gland2.22634038
14MP0003787_abnormal_imprinting2.16001311
15MP0005464_abnormal_platelet_physiology2.15332129
16MP0003763_abnormal_thymus_physiology2.14837166
17MP0005000_abnormal_immune_tolerance2.13919096
18MP0002398_abnormal_bone_marrow2.12299245
19MP0005671_abnormal_response_to2.10132830
20MP0002452_abnormal_antigen_presenting2.07055756
21MP0002723_abnormal_immune_serum2.06199550
22MP0000689_abnormal_spleen_morphology2.02966155
23MP0009278_abnormal_bone_marrow2.01025218
24MP0002420_abnormal_adaptive_immunity2.00800816
25MP0001819_abnormal_immune_cell1.94808673
26MP0008057_abnormal_DNA_replication1.91292049
27MP0002009_preneoplasia1.88872248
28MP0004185_abnormal_adipocyte_glucose1.87612351
29MP0001968_abnormal_touch/_nociception1.85904225
30MP0002148_abnormal_hypersensitivity_rea1.79161736
31MP0005397_hematopoietic_system_phenotyp1.77364238
32MP0001545_abnormal_hematopoietic_system1.77364238
33MP0005075_abnormal_melanosome_morpholog1.69858999
34MP0000716_abnormal_immune_system1.68775367
35MP0005645_abnormal_hypothalamus_physiol1.63531039
36MP0002405_respiratory_system_inflammati1.60266660
37MP0002722_abnormal_immune_system1.58281164
38MP0003183_abnormal_peptide_metabolism1.52756366
39MP0004808_abnormal_hematopoietic_stem1.52629311
40MP0002429_abnormal_blood_cell1.51724170
41MP0003806_abnormal_nucleotide_metabolis1.51022889
42MP0000015_abnormal_ear_pigmentation1.47866102
43MP0001873_stomach_inflammation1.46003937
44MP0003786_premature_aging1.41518591
45MP0001986_abnormal_taste_sensitivity1.41435336
46MP0005410_abnormal_fertilization1.36749569
47MP0004147_increased_porphyrin_level1.31403169
48MP0000371_diluted_coat_color1.28567569
49MP0000465_gastrointestinal_hemorrhage1.23562595
50MP0000703_abnormal_thymus_morphology1.23312103
51MP0002019_abnormal_tumor_incidence1.22601835
52MP0000569_abnormal_digit_pigmentation1.19164584
53MP0003111_abnormal_nucleus_morphology1.15025698
54MP0005646_abnormal_pituitary_gland1.14248634
55MP0001764_abnormal_homeostasis1.12718898
56MP0005025_abnormal_response_to1.12660980
57MP0006036_abnormal_mitochondrial_physio1.06290455
58MP0002736_abnormal_nociception_after1.04960173
59MP0008007_abnormal_cellular_replicative1.04271776
60MP0005220_abnormal_exocrine_pancreas1.02659622
61MP0010155_abnormal_intestine_physiology1.01800596
62MP0002166_altered_tumor_susceptibility0.99263039
63MP0002419_abnormal_innate_immunity0.98966045
64MP0001661_extended_life_span0.98806839
65MP0009379_abnormal_foot_pigmentation0.98369300
66MP0010386_abnormal_urinary_bladder0.97662596
67MP0005551_abnormal_eye_electrophysiolog0.95011267
68MP0002075_abnormal_coat/hair_pigmentati0.91430161
69MP0001845_abnormal_inflammatory_respons0.90895459
70MP0005174_abnormal_tail_pigmentation0.90700615
71MP0003436_decreased_susceptibility_to0.87815604
72MP0002006_tumorigenesis0.86828708
73MP0002693_abnormal_pancreas_physiology0.85061848
74MP0009785_altered_susceptibility_to0.84906271
75MP0008872_abnormal_physiological_respon0.82637642
76MP0008775_abnormal_heart_ventricle0.81505615
77MP0005266_abnormal_metabolism0.81477411
78MP0003646_muscle_fatigue0.81011617
79MP0001929_abnormal_gametogenesis0.80119452
80MP0000013_abnormal_adipose_tissue0.76590392
81MP0004742_abnormal_vestibular_system0.75958617
82MP0005636_abnormal_mineral_homeostasis0.73081029
83MP0005083_abnormal_biliary_tract0.72863253
84MP0001881_abnormal_mammary_gland0.70037768
85MP0003303_peritoneal_inflammation0.68690681
86MP0005171_absent_coat_pigmentation0.68637151
87MP0003698_abnormal_male_reproductive0.68435387
88MP0002095_abnormal_skin_pigmentation0.68010408
89MP0000372_irregular_coat_pigmentation0.66674403
90MP0003077_abnormal_cell_cycle0.64421231
91MP0002837_dystrophic_cardiac_calcinosis0.62834431
92MP0005084_abnormal_gallbladder_morpholo0.62658900
93MP0008469_abnormal_protein_level0.62417767
94MP0003011_delayed_dark_adaptation0.61431864
95MP0005334_abnormal_fat_pad0.61032742
96MP0000609_abnormal_liver_physiology0.60794991
97MP0002876_abnormal_thyroid_physiology0.60472956
98MP0000313_abnormal_cell_death0.59575604
99MP0002083_premature_death0.59260619
100MP0005666_abnormal_adipose_tissue0.58934930

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)8.16291885
2Panhypogammaglobulinemia (HP:0003139)5.50802865
3B lymphocytopenia (HP:0010976)5.49079455
4Abnormality of B cell number (HP:0010975)5.16927353
5Cellulitis (HP:0100658)3.96761217
6Severe combined immunodeficiency (HP:0004430)3.93323556
7Hypoplasia of the thymus (HP:0000778)3.80473197
8Prostate neoplasm (HP:0100787)3.77071297
9Abnormality of the prostate (HP:0008775)3.73071018
10Genetic anticipation (HP:0003743)3.71608352
11Recurrent viral infections (HP:0004429)3.62184211
12Meningitis (HP:0001287)3.40479563
13Thyroiditis (HP:0100646)3.37497376
14Papilloma (HP:0012740)3.33212227
15Verrucae (HP:0200043)3.33212227
16Combined immunodeficiency (HP:0005387)3.32013402
17Progressive external ophthalmoplegia (HP:0000590)3.14547855
18Visual hallucinations (HP:0002367)3.11336713
19Chromosomal breakage induced by crosslinking agents (HP:0003221)3.03974132
20Recurrent bronchitis (HP:0002837)3.00768349
21Chromsome breakage (HP:0040012)3.00040105
22Metaphyseal dysplasia (HP:0100255)2.93678914
23Gaze-evoked nystagmus (HP:0000640)2.93670942
24Sepsis (HP:0100806)2.86114867
25Severe visual impairment (HP:0001141)2.81462247
26Chronic otitis media (HP:0000389)2.79126213
27Acute lymphatic leukemia (HP:0006721)2.78609304
28Osteomyelitis (HP:0002754)2.77299955
29Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.76173856
30Abnormal biliary tract physiology (HP:0012439)2.72203054
31Bile duct proliferation (HP:0001408)2.72203054
32Absence seizures (HP:0002121)2.71865087
33Absent/shortened dynein arms (HP:0200106)2.70720993
34Dynein arm defect of respiratory motile cilia (HP:0012255)2.70720993
35Constricted visual fields (HP:0001133)2.68898069
36IgG deficiency (HP:0004315)2.64542122
37Aplasia/Hypoplasia of the thymus (HP:0010515)2.61364790
38Clubbing of toes (HP:0100760)2.56948758
39Hypoproteinemia (HP:0003075)2.56650399
40Recurrent sinusitis (HP:0011108)2.53816440
41Dialeptic seizures (HP:0011146)2.52329444
42Autoimmune hemolytic anemia (HP:0001890)2.50960676
43Duplicated collecting system (HP:0000081)2.50209630
44Chronic sinusitis (HP:0011109)2.48932714
45Recurrent pneumonia (HP:0006532)2.44915260
46Colitis (HP:0002583)2.44455536
47Recurrent fungal infections (HP:0002841)2.41150159
48Encephalitis (HP:0002383)2.39416047
49Abnormality of the renal collecting system (HP:0004742)2.38027384
50Neurodegeneration (HP:0002180)2.36130105
51Gastrointestinal inflammation (HP:0004386)2.31377771
52Autoimmune thrombocytopenia (HP:0001973)2.31247339
53Myelodysplasia (HP:0002863)2.25378757
54Abnormality of male internal genitalia (HP:0000022)2.20655344
55Limb hypertonia (HP:0002509)2.20598877
56Birth length less than 3rd percentile (HP:0003561)2.20026472
57Recurrent lower respiratory tract infections (HP:0002783)2.18069745
58Inflammation of the large intestine (HP:0002037)2.15129424
59Granulocytopenia (HP:0001913)2.14963818
60Stomach cancer (HP:0012126)2.13040787
61Recurrent bacterial skin infections (HP:0005406)2.12921065
62Congenital stationary night blindness (HP:0007642)2.11776053
63Attenuation of retinal blood vessels (HP:0007843)2.11772636
64IgM deficiency (HP:0002850)2.09201284
65Abnormality of macular pigmentation (HP:0008002)2.08755248
66Neutropenia (HP:0001875)2.07650752
67Dysmetric saccades (HP:0000641)2.06371970
68Abnormality of the hepatic vasculature (HP:0006707)2.05615453
69Ragged-red muscle fibers (HP:0003200)2.04593018
70Gastrointestinal stroma tumor (HP:0100723)2.02885876
71Pendular nystagmus (HP:0012043)1.99668015
72Abnormality of chromosome stability (HP:0003220)1.98569748
73Eosinophilia (HP:0001880)1.95084472
74Brushfield spots (HP:0001088)1.91651085
75Abnormality of T cell physiology (HP:0011840)1.91178611
76Increased intramyocellular lipid droplets (HP:0012240)1.90706757
77Abnormality of the thymus (HP:0000777)1.89752875
78Adactyly (HP:0009776)1.88676341
79Hypochromic microcytic anemia (HP:0004840)1.88659058
80Recurrent abscess formation (HP:0002722)1.87630348
81Abnormality of T cells (HP:0002843)1.87506838
82Viral hepatitis (HP:0006562)1.86439947
83Abnormality of the preputium (HP:0100587)1.85733183
84Skin rash (HP:0000988)1.83929295
85Lymphoma (HP:0002665)1.83725249
86Lymphopenia (HP:0001888)1.82191930
87Colon cancer (HP:0003003)1.81225345
88Abnormality of the heme biosynthetic pathway (HP:0010472)1.80373841
89Nonimmune hydrops fetalis (HP:0001790)1.79447409
90Impaired proprioception (HP:0010831)1.79380398
91Focal motor seizures (HP:0011153)1.78696452
92Microvesicular hepatic steatosis (HP:0001414)1.78053751
93Truncus arteriosus (HP:0001660)1.77762379
94Neoplasm of the adrenal cortex (HP:0100641)1.76401584
95Squamous cell carcinoma (HP:0002860)1.74108535
96Increased IgE level (HP:0003212)1.74015256
97Aplasia/Hypoplasia of the uvula (HP:0010293)1.72299684
98Abnormality of lateral ventricle (HP:0030047)1.70790608
99Medial flaring of the eyebrow (HP:0010747)1.68521720
100Impaired vibratory sensation (HP:0002495)1.68203593

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TEC4.09938436
2EIF2AK33.81660953
3MAP4K23.61267968
4FRK3.60983333
5TAOK33.11879894
6BTK2.80622387
7ITK2.78458845
8CCNB12.42314703
9KIT2.30437437
10SYK2.24135773
11SCYL22.22659217
12BLK2.14223896
13MAP4K12.14051467
14KSR22.12565089
15CDK192.10627678
16ZAK1.99169703
17FLT31.97330508
18ERN11.81534143
19OXSR11.74232058
20NUAK11.72000836
21RAF11.70263201
22NTRK31.69316618
23RIPK41.67818039
24MAP3K21.61681490
25PIK3CG1.50015756
26PIK3CA1.32934650
27LYN1.29094442
28MAPKAPK31.24005743
29MAP2K11.22753326
30PBK1.17401482
31EIF2AK21.17101967
32HCK1.15585859
33CSF1R1.14216283
34TTK1.12106413
35GRK11.09851802
36KSR11.07568985
37INSRR1.07351899
38STK31.05445653
39TNK20.97946648
40PIM10.95812416
41CLK10.95772889
42EEF2K0.90226045
43KDR0.87663949
44ADRBK20.87568186
45DAPK10.85187236
46PINK10.83369144
47ATR0.83164116
48SIK20.82588137
49LCK0.80348020
50ACVR1B0.80102646
51TXK0.79966448
52CDK30.78748570
53MARK30.78433151
54RPS6KB20.78298130
55MAPKAPK50.77300675
56NEK20.76720380
57MAPK110.74182206
58IRAK40.73320034
59DYRK30.72773581
60BMPR20.70443520
61LATS10.70055733
62VRK20.68820661
63CDK40.68310736
64JAK20.68128083
65IKBKE0.66478751
66CDC70.66417037
67WNK40.65473510
68JAK30.64930842
69STK160.61587053
70CDK80.60733030
71CHEK20.60044440
72TIE10.56285053
73MELK0.54503562
74MAP3K10.51519127
75GRK60.51212943
76FES0.49166573
77MAP3K140.47538683
78MAPK130.45608990
79MAP3K80.44093762
80RPS6KA60.43984975
81TYK20.43305875
82ATM0.42741760
83ABL10.42583078
84PRKCQ0.40681648
85RPS6KB10.40571109
86MST40.40035256
87ADRBK10.37810702
88MAPK70.37479744
89CDK90.36351022
90MAPK120.36173088
91TESK20.34673919
92CDK120.32921199
93MAPK30.32784839
94MAPKAPK20.32241930
95MKNK10.31677743
96CHEK10.31503018
97RPS6KA50.29726754
98BRD40.28618857
99MAP3K50.28039937
100CDK20.27855831

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.50802533
2Intestinal immune network for IgA production_Homo sapiens_hsa046723.47035246
3Homologous recombination_Homo sapiens_hsa034403.40133478
4Asthma_Homo sapiens_hsa053103.03445954
5Non-homologous end-joining_Homo sapiens_hsa034502.95368866
6B cell receptor signaling pathway_Homo sapiens_hsa046622.76193860
7Allograft rejection_Homo sapiens_hsa053302.63356112
8Mismatch repair_Homo sapiens_hsa034302.58422233
9Autoimmune thyroid disease_Homo sapiens_hsa053202.29746985
10Graft-versus-host disease_Homo sapiens_hsa053322.27119991
11Fanconi anemia pathway_Homo sapiens_hsa034602.25228118
12DNA replication_Homo sapiens_hsa030302.24822109
13Type I diabetes mellitus_Homo sapiens_hsa049401.98952338
14Base excision repair_Homo sapiens_hsa034101.92797072
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.84323249
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.82726345
17One carbon pool by folate_Homo sapiens_hsa006701.82317228
18Caffeine metabolism_Homo sapiens_hsa002321.76290787
19Leishmaniasis_Homo sapiens_hsa051401.66456449
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.62303637
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.53945346
22Hematopoietic cell lineage_Homo sapiens_hsa046401.52821548
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.50024195
24Staphylococcus aureus infection_Homo sapiens_hsa051501.29297445
25Antigen processing and presentation_Homo sapiens_hsa046121.26856201
26Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.24775636
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.22797782
28Olfactory transduction_Homo sapiens_hsa047401.22270118
29Herpes simplex infection_Homo sapiens_hsa051681.21279000
30Nucleotide excision repair_Homo sapiens_hsa034201.19188398
31Butanoate metabolism_Homo sapiens_hsa006501.14434430
32Ether lipid metabolism_Homo sapiens_hsa005651.12408422
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.10680449
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.10674909
35Platelet activation_Homo sapiens_hsa046111.07068250
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04779102
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.04091911
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02542617
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00304290
40Phototransduction_Homo sapiens_hsa047440.95404249
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93949625
42Peroxisome_Homo sapiens_hsa041460.90634375
43Purine metabolism_Homo sapiens_hsa002300.90256525
44Jak-STAT signaling pathway_Homo sapiens_hsa046300.89883821
45Linoleic acid metabolism_Homo sapiens_hsa005910.88181309
46Regulation of autophagy_Homo sapiens_hsa041400.86454934
47Systemic lupus erythematosus_Homo sapiens_hsa053220.83216606
48Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80828758
49Influenza A_Homo sapiens_hsa051640.78719242
50RNA degradation_Homo sapiens_hsa030180.76636676
51Pyrimidine metabolism_Homo sapiens_hsa002400.76268680
52RNA polymerase_Homo sapiens_hsa030200.75620267
53Nitrogen metabolism_Homo sapiens_hsa009100.73414937
54Salivary secretion_Homo sapiens_hsa049700.72506526
55Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71831063
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71732508
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68296756
58Vitamin B6 metabolism_Homo sapiens_hsa007500.64428568
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.62783702
60Selenocompound metabolism_Homo sapiens_hsa004500.60943168
61Viral myocarditis_Homo sapiens_hsa054160.60896140
62Tuberculosis_Homo sapiens_hsa051520.59831681
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58800488
64Retinol metabolism_Homo sapiens_hsa008300.58228528
65Acute myeloid leukemia_Homo sapiens_hsa052210.57755946
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55869629
67Osteoclast differentiation_Homo sapiens_hsa043800.55428409
68p53 signaling pathway_Homo sapiens_hsa041150.53607600
69Cell cycle_Homo sapiens_hsa041100.53513485
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53208079
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51920601
72Arachidonic acid metabolism_Homo sapiens_hsa005900.47080709
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46241729
74African trypanosomiasis_Homo sapiens_hsa051430.44265380
75Other glycan degradation_Homo sapiens_hsa005110.44096340
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.43684321
77Toxoplasmosis_Homo sapiens_hsa051450.43109859
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42789949
79T cell receptor signaling pathway_Homo sapiens_hsa046600.42388064
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.41921705
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41185019
82HTLV-I infection_Homo sapiens_hsa051660.41122347
83Spliceosome_Homo sapiens_hsa030400.40488874
84Tryptophan metabolism_Homo sapiens_hsa003800.40304755
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40089494
86Chemical carcinogenesis_Homo sapiens_hsa052040.40087069
87Rheumatoid arthritis_Homo sapiens_hsa053230.40035217
88Measles_Homo sapiens_hsa051620.39579021
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39174372
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38220090
91Basal transcription factors_Homo sapiens_hsa030220.38164087
92Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37892130
93Starch and sucrose metabolism_Homo sapiens_hsa005000.36910532
94Long-term depression_Homo sapiens_hsa047300.35729715
95RNA transport_Homo sapiens_hsa030130.34858214
96Viral carcinogenesis_Homo sapiens_hsa052030.34120852
97Epstein-Barr virus infection_Homo sapiens_hsa051690.33266549
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.32503869
99Calcium signaling pathway_Homo sapiens_hsa040200.32342714
100Non-small cell lung cancer_Homo sapiens_hsa052230.30549344

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