ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	chromosome organization involved in meiosis (GO:0070192)	7.78323089
2	male meiosis I (GO:0007141)	7.70758334
3	DNA synthesis involved in DNA repair (GO:0000731)	6.74158625
4	piRNA metabolic process (GO:0034587)	6.53649736
5	male meiosis (GO:0007140)	6.47740819
6	synaptonemal complex assembly (GO:0007130)	6.37916661
7	meiosis I (GO:0007127)	6.05252160
8	synaptonemal complex organization (GO:0070193)	6.01763249
9	meiotic nuclear division (GO:0007126)	5.35686269
10	DNA methylation involved in gamete generation (GO:0043046)	5.06930857
11	cellular response to interleukin-15 (GO:0071350)	4.88702485
12	sister chromatid cohesion (GO:0007062)	4.86929345
13	positive regulation of B cell differentiation (GO:0045579)	4.43590000
14	attachment of spindle microtubules to kinetochore (GO:0008608)	4.39000182
15	reciprocal DNA recombination (GO:0035825)	4.38732751
16	reciprocal meiotic recombination (GO:0007131)	4.38732751
17	meiotic cell cycle process (GO:1903046)	4.33033171
18	regulation of meiosis I (GO:0060631)	4.25900013
19	arginine catabolic process (GO:0006527)	4.22479761
20	response to pheromone (GO:0019236)	4.20320852
21	resolution of meiotic recombination intermediates (GO:0000712)	3.92757904
22	viral protein processing (GO:0019082)	3.87658604
23	amine catabolic process (GO:0009310)	3.80522353
24	cellular biogenic amine catabolic process (GO:0042402)	3.80522353
25	regulation of DNA endoreduplication (GO:0032875)	3.67775518
26	secondary metabolite biosynthetic process (GO:0044550)	3.62788479
27	melanin biosynthetic process (GO:0042438)	3.59644475
28	indole-containing compound catabolic process (GO:0042436)	3.58062102
29	indolalkylamine catabolic process (GO:0046218)	3.58062102
30	tryptophan catabolic process (GO:0006569)	3.58062102
31	positive regulation of cellular response to oxidative stress (GO:1900409)	3.50394723
32	positive regulation of response to oxidative stress (GO:1902884)	3.50394723
33	response to interleukin-15 (GO:0070672)	3.47242310
34	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	3.44434320
35	acrosome assembly (GO:0001675)	3.41890177
36	positive regulation of interleukin-8 biosynthetic process (GO:0045416)	3.41089509
37	aromatic amino acid family catabolic process (GO:0009074)	3.37217925
38	intestinal epithelial cell development (GO:0060576)	3.34378523
39	cellular response to nicotine (GO:0071316)	3.28460470
40	negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)	3.24013421
41	parental behavior (GO:0060746)	3.23539773
42	arginine metabolic process (GO:0006525)	3.17547415
43	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	3.15530681
44	melanin metabolic process (GO:0006582)	3.13968754
45	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.13768225
46	L-phenylalanine catabolic process (GO:0006559)	3.13768225
47	N-terminal protein amino acid acetylation (GO:0006474)	3.12819262
48	positive regulation of protein homooligomerization (GO:0032464)	3.10847573
49	protein K6-linked ubiquitination (GO:0085020)	3.09615781
50	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.07428468
51	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.07428468
52	isotype switching (GO:0045190)	3.07428468
53	tryptophan metabolic process (GO:0006568)	3.04502940
54	L-fucose catabolic process (GO:0042355)	3.02801515
55	fucose catabolic process (GO:0019317)	3.02801515
56	L-fucose metabolic process (GO:0042354)	3.02801515
57	mature B cell differentiation involved in immune response (GO:0002313)	3.02658207
58	oocyte development (GO:0048599)	3.02491606
59	glyoxylate metabolic process (GO:0046487)	2.98989897
60	aromatic amino acid family metabolic process (GO:0009072)	2.98592676
61	regulation of double-strand break repair via homologous recombination (GO:0010569)	2.94728301
62	tyrosine metabolic process (GO:0006570)	2.91646296
63	cilium or flagellum-dependent cell motility (GO:0001539)	2.91419303
64	brain morphogenesis (GO:0048854)	2.90801233
65	alkaloid metabolic process (GO:0009820)	2.89599400
66	protein K11-linked deubiquitination (GO:0035871)	2.84546893
67	positive regulation of meiosis (GO:0045836)	2.84525946
68	negative regulation of thymocyte apoptotic process (GO:0070244)	2.84044123
69	transcription from mitochondrial promoter (GO:0006390)	2.82888124
70	B cell activation involved in immune response (GO:0002312)	2.82266187
71	diterpenoid biosynthetic process (GO:0016102)	2.79991875
72	regulation of RIG-I signaling pathway (GO:0039535)	2.77340668
73	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.76846060
74	regulation of podosome assembly (GO:0071801)	2.74949799
75	response to vitamin E (GO:0033197)	2.71381270
76	regulation of vitamin D biosynthetic process (GO:0060556)	2.71196105
77	positive regulation of developmental pigmentation (GO:0048087)	2.69990067
78	mitotic sister chromatid cohesion (GO:0007064)	2.69663915
79	DNA catabolic process, exonucleolytic (GO:0000738)	2.69514853
80	negative regulation of JUN kinase activity (GO:0043508)	2.68934563
81	positive regulation of meiotic cell cycle (GO:0051446)	2.64102416
82	regulation of alkaline phosphatase activity (GO:0010692)	2.62575809
83	exocrine pancreas development (GO:0031017)	2.58760242
84	cellular response to dsRNA (GO:0071359)	2.58291244
85	DNA biosynthetic process (GO:0071897)	2.57795210
86	regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	2.57389865
87	DNA double-strand break processing (GO:0000729)	2.57035551
88	mature B cell differentiation (GO:0002335)	2.55836836
89	serine family amino acid catabolic process (GO:0009071)	2.52216131
90	indolalkylamine metabolic process (GO:0006586)	2.50365948
91	regulation of chronic inflammatory response (GO:0002676)	2.50033544
92	regulation of histone H3-K9 methylation (GO:0051570)	2.48539294
93	chronic inflammatory response (GO:0002544)	2.47930621
94	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.47837364
95	L-phenylalanine metabolic process (GO:0006558)	2.47837364
96	negative regulation of T-helper cell differentiation (GO:0045623)	2.46039415
97	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	2.46039415
98	regulation of triglyceride catabolic process (GO:0010896)	2.44603861
99	histone H2A acetylation (GO:0043968)	2.43738749
100	synapsis (GO:0007129)	10.8025050

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IRF8_22096565_ChIP-ChIP_GC-B_Human	5.62693103
2	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	3.02508405
3	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.91169674
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.44176013
5	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.35859414
6	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.31331960
7	FUS_26573619_Chip-Seq_HEK293_Human	2.26543847
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.25703052
9	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.22382411
10	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.15982632
11	ER_23166858_ChIP-Seq_MCF-7_Human	2.10587307
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.09260823
13	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.98466146
14	EWS_26573619_Chip-Seq_HEK293_Human	1.97837312
15	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.97070337
16	BCAT_22108803_ChIP-Seq_LS180_Human	1.90904343
17	ZNF274_21170338_ChIP-Seq_K562_Hela	1.87621834
18	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.79192431
19	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.72263555
20	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.66545855
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.61557742
22	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.59693597
23	PHF8_20622853_ChIP-Seq_HELA_Human	1.56755996
24	P300_19829295_ChIP-Seq_ESCs_Human	1.56235729
25	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.55550329
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.54636415
27	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.52857688
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.52335775
29	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.52276513
30	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.48929737
31	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.47496801
32	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.44816307
33	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.44488523
34	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.42375556
35	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.42055968
36	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.42046953
37	RBPJ_21746931_ChIP-Seq_IB4_Human	1.41916980
38	NFYB_21822215_ChIP-Seq_K562_Human	1.39699845
39	AR_25329375_ChIP-Seq_VCAP_Human	1.39693256
40	CBP_20019798_ChIP-Seq_JUKART_Human	1.37628375
41	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.37628375
42	CDX2_22108803_ChIP-Seq_LS180_Human	1.36580178
43	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.36309855
44	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.35515891
45	NFYA_21822215_ChIP-Seq_K562_Human	1.33164024
46	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.33140442
47	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.32860213
48	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.32622484
49	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.31741055
50	TAF15_26573619_Chip-Seq_HEK293_Human	1.30860734
51	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.29580726
52	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.28651657
53	ETV1_20927104_ChIP-Seq_GIST48_Human	1.27634399
54	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.27573816
55	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.26581969
56	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.25404248
57	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.23956949
58	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.23205584
59	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.23126512
60	TP53_22573176_ChIP-Seq_HFKS_Human	1.20023307
61	GATA3_26560356_Chip-Seq_TH2_Human	1.19983293
62	GATA3_26560356_Chip-Seq_TH1_Human	1.18990739
63	VDR_24787735_ChIP-Seq_THP-1_Human	1.18116631
64	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.17697014
65	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.17697014
66	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.16639719
67	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.15968315
68	VDR_22108803_ChIP-Seq_LS180_Human	1.15704657
69	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.15684807
70	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.15350398
71	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.15330422
72	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.15315987
73	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.13806469
74	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.12466816
75	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.12346355
76	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.12267032
77	SMRT_27268052_Chip-Seq_Bcells_Human	1.11199303
78	EZH2_22144423_ChIP-Seq_EOC_Human	1.10947325
79	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.10545873
80	IGF1R_20145208_ChIP-Seq_DFB_Human	1.08044974
81	RUNX1_27457419_Chip-Seq_LIVER_Mouse	1.06743320
82	TCF4_23295773_ChIP-Seq_U87_Human	1.05575760
83	P53_22387025_ChIP-Seq_ESCs_Mouse	1.05244839
84	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.04959449
85	NANOG_19829295_ChIP-Seq_ESCs_Human	1.04639236
86	SOX2_19829295_ChIP-Seq_ESCs_Human	1.04639236
87	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.04058616
88	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.03864297
89	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.02831401
90	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.02361882
91	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.01985643
92	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.01823693
93	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.01470996
94	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.01435999
95	RUNX_20019798_ChIP-Seq_JUKART_Human	1.01091948
96	DCP1A_22483619_ChIP-Seq_HELA_Human	1.00999952
97	TBL1_22424771_ChIP-Seq_293T_Human	1.00820025
98	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.00643301
99	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.00590989
100	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.00261901

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	5.11372550
2	MP0000569_abnormal_digit_pigmentation	4.48101560
3	MP0002138_abnormal_hepatobiliary_system	3.64087154
4	MP0002139_abnormal_hepatobiliary_system	3.56974658
5	MP0008057_abnormal_DNA_replication	3.51775755
6	MP0005174_abnormal_tail_pigmentation	3.05587105
7	MP0000015_abnormal_ear_pigmentation	2.89352311
8	MP0009697_abnormal_copulation	2.80686422
9	MP0008007_abnormal_cellular_replicative	2.77448773
10	MP0000372_irregular_coat_pigmentation	2.73867585
11	MP0000685_abnormal_immune_system	2.65007388
12	MP0003787_abnormal_imprinting	2.57560804
13	MP0005171_absent_coat_pigmentation	2.55781554
14	MP0002095_abnormal_skin_pigmentation	2.55759522
15	MP0008058_abnormal_DNA_repair	2.49571560
16	MP0002653_abnormal_ependyma_morphology	2.40309356
17	MP0005075_abnormal_melanosome_morpholog	2.38791707
18	MP0010094_abnormal_chromosome_stability	2.24164759
19	MP0005408_hypopigmentation	2.21494446
20	MP0002876_abnormal_thyroid_physiology	2.12553975
21	MP0006036_abnormal_mitochondrial_physio	2.11768934
22	MP0000371_diluted_coat_color	2.11200776
23	MP0000427_abnormal_hair_cycle	2.00450224
24	MP0003136_yellow_coat_color	1.99690070
25	MP0002210_abnormal_sex_determination	1.81556437
26	MP0006035_abnormal_mitochondrial_morpho	1.74487553
27	MP0001929_abnormal_gametogenesis	1.73351712
28	MP0005671_abnormal_response_to	1.71452374
29	MP0005647_abnormal_sex_gland	1.70232775
30	MP0003172_abnormal_lysosome_physiology	1.62919994
31	MP0001835_abnormal_antigen_presentation	1.61131988
32	MP0003186_abnormal_redox_activity	1.56167322
33	MP0003252_abnormal_bile_duct	1.52465399
34	MP0002160_abnormal_reproductive_system	1.52456530
35	MP0002163_abnormal_gland_morphology	1.47150232
36	MP0005389_reproductive_system_phenotype	1.45943731
37	MP0002148_abnormal_hypersensitivity_rea	1.44346138
38	MP0001145_abnormal_male_reproductive	1.40564890
39	MP0008875_abnormal_xenobiotic_pharmacok	1.39572753
40	MP0001800_abnormal_humoral_immune	1.36941554
41	MP0000653_abnormal_sex_gland	1.36368477
42	MP0003195_calcinosis	1.33920615
43	MP0002837_dystrophic_cardiac_calcinosis	1.30935707
44	MP0003646_muscle_fatigue	1.30566656
45	MP0003698_abnormal_male_reproductive	1.29720508
46	MP0005360_urolithiasis	1.28637615
47	MP0003868_abnormal_feces_composition	1.28533111
48	MP0002102_abnormal_ear_morphology	1.28283677
49	MP0005085_abnormal_gallbladder_physiolo	1.26001448
50	MP0005464_abnormal_platelet_physiology	1.25539621
51	MP0003121_genomic_imprinting	1.22527975
52	MP0001915_intracranial_hemorrhage	1.21056801
53	MP0002638_abnormal_pupillary_reflex	1.20063852
54	MP0003943_abnormal_hepatobiliary_system	1.19219289
55	MP0001119_abnormal_female_reproductive	1.16051598
56	MP0004036_abnormal_muscle_relaxation	1.12966105
57	MP0005167_abnormal_blood-brain_barrier	1.10705309
58	MP0001790_abnormal_immune_system	1.07256845
59	MP0005387_immune_system_phenotype	1.07256845
60	MP0005000_abnormal_immune_tolerance	1.07209869
61	MP0003880_abnormal_central_pattern	1.05672128
62	MP0005451_abnormal_body_composition	1.01398913
63	MP0004808_abnormal_hematopoietic_stem	0.99517511
64	MP0000358_abnormal_cell_content/	0.96455834
65	MP0001879_abnormal_lymphatic_vessel	0.93129675
66	MP0002075_abnormal_coat/hair_pigmentati	0.92147519
67	MP0004381_abnormal_hair_follicle	0.90279661
68	MP0001764_abnormal_homeostasis	0.89260193
69	MP0009333_abnormal_splenocyte_physiolog	0.80530053
70	MP0005365_abnormal_bile_salt	0.77521105
71	MP0003123_paternal_imprinting	0.77083287
72	MP0001853_heart_inflammation	0.76171872
73	MP0002938_white_spotting	0.73661885
74	MP0009278_abnormal_bone_marrow	0.73595234
75	MP0003806_abnormal_nucleotide_metabolis	0.73332411
76	MP0005409_darkened_coat_color	0.72719116
77	MP0001243_abnormal_dermal_layer	0.71282088
78	MP0002452_abnormal_antigen_presenting	0.71034237
79	MP0001324_abnormal_eye_pigmentation	0.69820129
80	MP0005248_abnormal_Harderian_gland	0.68740698
81	MP0003077_abnormal_cell_cycle	0.68326758
82	MP0000383_abnormal_hair_follicle	0.68105607
83	MP0010307_abnormal_tumor_latency	0.67990975
84	MP0005266_abnormal_metabolism	0.67659085
85	MP0002723_abnormal_immune_serum	0.66227146
86	MP0005379_endocrine/exocrine_gland_phen	0.65266453
87	MP0001501_abnormal_sleep_pattern	0.65214102
88	MP0001919_abnormal_reproductive_system	0.64499563
89	MP0001661_extended_life_span	0.64497518
90	MP0002166_altered_tumor_susceptibility	0.64458673
91	MP0009785_altered_susceptibility_to	0.63990849
92	MP0010368_abnormal_lymphatic_system	0.63873422
93	MP0002089_abnormal_postnatal_growth/wei	0.63796413
94	MP0003763_abnormal_thymus_physiology	0.63678328
95	MP0001440_abnormal_grooming_behavior	0.61292695
96	MP0009764_decreased_sensitivity_to	0.60796572
97	MP0009379_abnormal_foot_pigmentation	0.58731053
98	MP0005670_abnormal_white_adipose	0.55493644
99	MP0002019_abnormal_tumor_incidence	0.53190888
100	MP0001186_pigmentation_phenotype	0.52963420

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Agammaglobulinemia (HP:0004432)	5.60029097
2	Volvulus (HP:0002580)	4.56824554
3	B lymphocytopenia (HP:0010976)	4.44009625
4	Severe combined immunodeficiency (HP:0004430)	4.42587444
5	Type I transferrin isoform profile (HP:0003642)	4.33514356
6	Abnormality of the labia minora (HP:0012880)	4.29605537
7	Thyroiditis (HP:0100646)	4.25604399
8	Fair hair (HP:0002286)	4.16563272
9	Abnormality of B cell number (HP:0010975)	4.10713658
10	Generalized hypopigmentation of hair (HP:0011358)	3.99261388
11	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.98748893
12	Abnormality of pyrimidine metabolism (HP:0004353)	3.90914875
13	Combined immunodeficiency (HP:0005387)	3.86742591
14	Chromsome breakage (HP:0040012)	3.83161544
15	Horizontal nystagmus (HP:0000666)	3.65755979
16	Chronic sinusitis (HP:0011109)	3.65725047
17	Chronic diarrhea (HP:0002028)	3.36296106
18	Nausea (HP:0002018)	3.29493281
19	Blue irides (HP:0000635)	3.14960826
20	Azoospermia (HP:0000027)	3.09147544
21	Duplicated collecting system (HP:0000081)	3.08285043
22	Follicular hyperkeratosis (HP:0007502)	3.01636662
23	Abnormality of chromosome stability (HP:0003220)	2.97090181
24	Recurrent sinusitis (HP:0011108)	2.92797783
25	Hypoproteinemia (HP:0003075)	2.89765831
26	Abnormality of the renal collecting system (HP:0004742)	2.85953848
27	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.80578813
28	Recurrent pneumonia (HP:0006532)	2.80450366
29	Congenital stationary night blindness (HP:0007642)	2.80263913
30	Hypoplasia of the thymus (HP:0000778)	2.78826624
31	Reduced antithrombin III activity (HP:0001976)	2.77181512
32	Congenital, generalized hypertrichosis (HP:0004540)	2.73367384
33	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.66924002
34	Opisthotonus (HP:0002179)	2.63158380
35	Abnormal glycosylation (HP:0012345)	2.57865176
36	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.57865176
37	Abnormal protein N-linked glycosylation (HP:0012347)	2.57865176
38	Abnormal protein glycosylation (HP:0012346)	2.57865176
39	Conjunctival telangiectasia (HP:0000524)	2.55364524
40	Small hand (HP:0200055)	2.52988242
41	Exotropia (HP:0000577)	2.48906027
42	Hypobetalipoproteinemia (HP:0003563)	2.48386815
43	Purpura (HP:0000979)	2.40382797
44	Reticulocytopenia (HP:0001896)	2.37951558
45	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.37721977
46	Inappropriate behavior (HP:0000719)	2.37579449
47	Petechiae (HP:0000967)	2.34902533
48	Ocular albinism (HP:0001107)	2.33714916
49	Mesangial abnormality (HP:0001966)	2.29657020
50	Sepsis (HP:0100806)	2.29522629
51	Ectopic kidney (HP:0000086)	2.29283193
52	Dry hair (HP:0011359)	2.27948293
53	Albinism (HP:0001022)	2.27914603
54	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.27140079
55	3-Methylglutaconic aciduria (HP:0003535)	2.24298455
56	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.20565151
57	Absent speech (HP:0001344)	2.19857929
58	Cholecystitis (HP:0001082)	2.18763112
59	Abnormal gallbladder physiology (HP:0012438)	2.18763112
60	Hypoplastic labia majora (HP:0000059)	2.15903118
61	Abnormal spermatogenesis (HP:0008669)	2.15020999
62	Infantile muscular hypotonia (HP:0008947)	2.14333164
63	Breech presentation (HP:0001623)	2.12799315
64	Sparse lateral eyebrow (HP:0005338)	2.11020401
65	Verrucae (HP:0200043)	2.09234460
66	Papilloma (HP:0012740)	2.09234460
67	Iris hypopigmentation (HP:0007730)	2.08012972
68	Large earlobe (HP:0009748)	2.05917851
69	Generalized hypopigmentation (HP:0007513)	2.05641206
70	Meckel diverticulum (HP:0002245)	2.03682927
71	Absent thumb (HP:0009777)	2.02299988
72	Abnormality of the ileum (HP:0001549)	2.01250159
73	Bile duct proliferation (HP:0001408)	2.00535316
74	Abnormal biliary tract physiology (HP:0012439)	2.00535316
75	Chronic otitis media (HP:0000389)	1.94810410
76	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.91698861
77	Hypoplasia of the fovea (HP:0007750)	1.91698861
78	Birth length less than 3rd percentile (HP:0003561)	1.91482891
79	Abnormality of eosinophils (HP:0001879)	1.90783112
80	Abnormality of the labia majora (HP:0012881)	1.90756190
81	Duplication of thumb phalanx (HP:0009942)	1.90641491
82	Small intestinal stenosis (HP:0012848)	1.89243655
83	Duodenal stenosis (HP:0100867)	1.89243655
84	Abnormality of DNA repair (HP:0003254)	1.89188129
85	Abnormality of the preputium (HP:0100587)	1.86485338
86	Panhypogammaglobulinemia (HP:0003139)	1.85997123
87	Corneal dystrophy (HP:0001131)	1.85632682
88	Abnormality of the basal ganglia (HP:0002134)	1.83284583
89	Spontaneous abortion (HP:0005268)	1.80823998
90	Recurrent lower respiratory tract infections (HP:0002783)	1.79014319
91	Cellulitis (HP:0100658)	1.77518309
92	Limb dystonia (HP:0002451)	1.76183346
93	Abnormality of cochlea (HP:0000375)	1.75510874
94	11 pairs of ribs (HP:0000878)	1.73542969
95	Stomach cancer (HP:0012126)	1.72412315
96	Broad-based gait (HP:0002136)	1.71444801
97	Widely spaced teeth (HP:0000687)	1.70153739
98	Decreased lacrimation (HP:0000633)	1.68734784
99	Shawl scrotum (HP:0000049)	1.68501562
100	Aplasia/Hypoplasia of the macula (HP:0008059)	1.64877273

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	3.73896009
2	TRIM28	3.21457290
3	NEK6	2.30913434
4	CAMK1G	2.23288890
5	BMPR2	2.20022513
6	MAPKAPK3	2.11303316
7	WEE1	2.09523331
8	EPHA4	2.04392272
9	PDK2	11.4543990
10	MST4	1.78224948
11	EIF2AK1	1.73883779
12	FRK	1.64142083
13	EIF2AK3	1.61457367
14	PLK2	1.50483057
15	PTK2B	1.40034990
16	IRAK4	1.34724062
17	PKN1	1.29686567
18	TGFBR2	1.24545053
19	MAPK7	1.23713026
20	ZAK	1.20307663
21	SYK	1.11533276
22	CAMK1	1.07982641
23	MAPK12	1.01563042
24	MARK3	0.96104308
25	CLK1	0.95776317
26	PIK3CG	0.94224135
27	CSNK1G2	0.90015278
28	CAMK1D	0.87067714
29	MAPK13	0.84920391
30	CSNK1G3	0.83700719
31	PINK1	0.82133163
32	STK38L	0.81780885
33	TBK1	0.81738490
34	CSF1R	0.78195935
35	CSNK1G1	0.76806520
36	BLK	0.76730446
37	PAK3	0.75328345
38	WNK3	0.72318468
39	PIM2	0.70853436
40	STK3	0.70068892
41	PRKCI	0.69542436
42	DYRK1A	0.69329239
43	PDPK1	0.68364613
44	IRAK2	0.68321798
45	CCNB1	0.67998936
46	FER	0.65164693
47	NEK1	0.64660752
48	PDK1	0.64372995
49	FGFR2	0.64008736
50	OXSR1	0.62867974
51	MAP2K2	0.62571843
52	JAK3	0.62156926
53	IRAK1	0.61007737
54	HCK	0.59574551
55	MET	0.58602411
56	BTK	0.57971897
57	BMX	0.57924166
58	GRK5	0.57131796
59	OBSCN	0.56265997
60	BMPR1B	0.55557178
61	CSNK1A1L	0.54213156
62	MAPKAPK5	0.51439695
63	ABL1	0.49084978
64	NEK9	0.47048498
65	NUAK1	0.45613926
66	TNIK	0.44861436
67	IGF1R	0.43083540
68	ERBB3	0.42819038
69	TNK2	0.41485502
70	ATM	0.39154997
71	ARAF	0.38729823
72	CDK6	0.38715815
73	ROCK1	0.37941549
74	NME2	0.37168682
75	MAP2K1	0.34749265
76	EIF2AK2	0.33777936
77	MAP3K5	0.33397320
78	ATR	0.31525087
79	SIK2	0.29767098
80	PLK3	0.28940310
81	TEC	0.28877382
82	PRKAA2	0.28733978
83	CDK3	0.28676204
84	TTK	0.28179367
85	NEK2	0.28133407
86	FGFR1	0.28021768
87	EPHB2	0.27829004
88	BCKDK	0.27828946
89	LYN	0.27714547
90	IKBKB	0.27361403
91	KDR	0.26549816
92	PRKCE	0.26485646
93	PLK1	0.26483810
94	ERBB2	0.26037177
95	ZAP70	0.25498564
96	EGFR	0.25387495
97	BCR	0.24780837
98	ABL2	0.24624357
99	PRKCH	0.23548345
100	FGR	0.23242061

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Non-homologous end-joining_Homo sapiens_hsa03450	5.16430188
2	Primary immunodeficiency_Homo sapiens_hsa05340	3.51802454
3	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.18095815
4	Homologous recombination_Homo sapiens_hsa03440	2.67282373
5	Caffeine metabolism_Homo sapiens_hsa00232	2.40870522
6	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.39793032
7	Sulfur metabolism_Homo sapiens_hsa00920	2.29670430
8	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.24106235
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.16200009
10	Asthma_Homo sapiens_hsa05310	2.00486858
11	Phototransduction_Homo sapiens_hsa04744	1.89089712
12	Proteasome_Homo sapiens_hsa03050	1.88386985
13	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.77381732
14	Fanconi anemia pathway_Homo sapiens_hsa03460	1.75221161
15	Retinol metabolism_Homo sapiens_hsa00830	1.70937671
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.66919464
17	Selenocompound metabolism_Homo sapiens_hsa00450	1.66450740
18	Propanoate metabolism_Homo sapiens_hsa00640	1.57403790
19	PPAR signaling pathway_Homo sapiens_hsa03320	1.56959851
20	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.54347504
21	Chemical carcinogenesis_Homo sapiens_hsa05204	1.48821962
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.47826480
23	Allograft rejection_Homo sapiens_hsa05330	1.46959288
24	Parkinsons disease_Homo sapiens_hsa05012	1.45075838
25	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.42164776
26	Complement and coagulation cascades_Homo sapiens_hsa04610	1.36829407
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.26434236
28	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.24361491
29	Pyruvate metabolism_Homo sapiens_hsa00620	1.22797255
30	Graft-versus-host disease_Homo sapiens_hsa05332	1.22538788
31	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.21544719
32	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.18999402
33	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.18412664
34	Mismatch repair_Homo sapiens_hsa03430	1.18206280
35	Sulfur relay system_Homo sapiens_hsa04122	1.16122129
36	Peroxisome_Homo sapiens_hsa04146	1.10003987
37	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.08723636
38	Nucleotide excision repair_Homo sapiens_hsa03420	1.07670125
39	Nitrogen metabolism_Homo sapiens_hsa00910	0.99319835
40	Type I diabetes mellitus_Homo sapiens_hsa04940	0.99139613
41	Galactose metabolism_Homo sapiens_hsa00052	0.97707981
42	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.97511402
43	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.94583689
44	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.94226867
45	Cell cycle_Homo sapiens_hsa04110	0.93435016
46	Tyrosine metabolism_Homo sapiens_hsa00350	0.93090717
47	Huntingtons disease_Homo sapiens_hsa05016	0.92550744
48	Legionellosis_Homo sapiens_hsa05134	0.89607700
49	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.89132528
50	Regulation of autophagy_Homo sapiens_hsa04140	0.88132650
51	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.86455419
52	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.84430245
53	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.83690522
54	Basal transcription factors_Homo sapiens_hsa03022	0.83391471
55	Ether lipid metabolism_Homo sapiens_hsa00565	0.83284290
56	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.79480022
57	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.78903993
58	Butanoate metabolism_Homo sapiens_hsa00650	0.76472462
59	DNA replication_Homo sapiens_hsa03030	0.74401457
60	Oxidative phosphorylation_Homo sapiens_hsa00190	0.73478880
61	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.72469337
62	Glycerolipid metabolism_Homo sapiens_hsa00561	0.70114938
63	Viral myocarditis_Homo sapiens_hsa05416	0.68790035
64	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.67986091
65	Protein export_Homo sapiens_hsa03060	0.67408606
66	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.65779621
67	Base excision repair_Homo sapiens_hsa03410	0.65308891
68	African trypanosomiasis_Homo sapiens_hsa05143	0.65251743
69	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.64783689
70	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.63768359
71	beta-Alanine metabolism_Homo sapiens_hsa00410	0.61657114
72	Fatty acid degradation_Homo sapiens_hsa00071	0.60334911
73	Glutathione metabolism_Homo sapiens_hsa00480	0.59409624
74	Antigen processing and presentation_Homo sapiens_hsa04612	0.58673284
75	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.58526890
76	Rheumatoid arthritis_Homo sapiens_hsa05323	0.57797864
77	Metabolic pathways_Homo sapiens_hsa01100	0.57618188
78	Sphingolipid metabolism_Homo sapiens_hsa00600	0.56989774
79	One carbon pool by folate_Homo sapiens_hsa00670	0.56661280
80	p53 signaling pathway_Homo sapiens_hsa04115	0.51408732
81	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.51112708
82	Pentose phosphate pathway_Homo sapiens_hsa00030	0.50712200
83	Pyrimidine metabolism_Homo sapiens_hsa00240	0.50578178
84	Malaria_Homo sapiens_hsa05144	0.48364791
85	Phenylalanine metabolism_Homo sapiens_hsa00360	0.47084656
86	Other glycan degradation_Homo sapiens_hsa00511	0.46783180
87	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.46652445
88	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.44188149
89	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.42566100
90	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.41990865
91	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.40179127
92	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.39687028
93	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.38479050
94	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.38140341
95	Herpes simplex infection_Homo sapiens_hsa05168	0.37311773
96	Type II diabetes mellitus_Homo sapiens_hsa04930	0.36954036
97	Alzheimers disease_Homo sapiens_hsa05010	0.36384822
98	Collecting duct acid secretion_Homo sapiens_hsa04966	0.33368721
99	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.32351268
100	RNA polymerase_Homo sapiens_hsa03020	0.31201853

BNIP3P5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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