BOC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the immunoglobulin/fibronectin type III repeat family. It is a component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells, and promotes myogenic differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tongue development (GO:0043586)4.61187628
2planar cell polarity pathway involved in neural tube closure (GO:0090179)4.51641597
3protein heterotrimerization (GO:0070208)4.47943888
4bone trabecula formation (GO:0060346)4.47403700
5outer ear morphogenesis (GO:0042473)4.37636865
6collagen fibril organization (GO:0030199)4.35669822
7hemidesmosome assembly (GO:0031581)4.26586488
8regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.26530012
9radial glial cell differentiation (GO:0060019)4.14778174
10chondrocyte proliferation (GO:0035988)3.96992398
11lateral sprouting from an epithelium (GO:0060601)3.93898348
12sequestering of extracellular ligand from receptor (GO:0035581)3.93142221
13neuronal stem cell maintenance (GO:0097150)3.86061209
14nonmotile primary cilium assembly (GO:0035058)3.77243238
15axonal fasciculation (GO:0007413)3.71037842
16cell proliferation in forebrain (GO:0021846)3.70313465
17presynaptic membrane assembly (GO:0097105)3.68649409
18postsynaptic membrane organization (GO:0001941)3.66192081
19cerebral cortex radially oriented cell migration (GO:0021799)3.57267717
20negative regulation of catenin import into nucleus (GO:0035414)3.56319666
21dendritic spine morphogenesis (GO:0060997)3.55018806
22negative regulation of chondrocyte differentiation (GO:0032331)3.54769785
23limb development (GO:0060173)3.53688507
24appendage development (GO:0048736)3.53688507
25G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.50467756
26somite development (GO:0061053)3.50280718
27lens fiber cell development (GO:0070307)3.47582986
28establishment of planar polarity (GO:0001736)3.40793201
29establishment of tissue polarity (GO:0007164)3.40793201
30dermatan sulfate biosynthetic process (GO:0030208)3.35302074
31presynaptic membrane organization (GO:0097090)3.33300847
32collagen metabolic process (GO:0032963)3.32237098
33retinal ganglion cell axon guidance (GO:0031290)3.31774480
34pyrimidine nucleobase catabolic process (GO:0006208)3.30874630
35axon extension involved in axon guidance (GO:0048846)3.28663839
36neuron projection extension involved in neuron projection guidance (GO:1902284)3.28663839
37metanephric mesenchyme development (GO:0072075)3.26348114
38otic vesicle formation (GO:0030916)3.25590372
39regulation of non-canonical Wnt signaling pathway (GO:2000050)3.25390647
40collagen catabolic process (GO:0030574)3.25174864
41non-canonical Wnt signaling pathway (GO:0035567)3.24595364
42mesenchymal-epithelial cell signaling (GO:0060638)3.22727220
43endodermal cell differentiation (GO:0035987)3.22216957
44middle ear morphogenesis (GO:0042474)3.20979128
45multicellular organismal macromolecule metabolic process (GO:0044259)3.17708030
46Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.16826570
47insulin-like growth factor receptor signaling pathway (GO:0048009)3.16758840
48positive regulation of mesenchymal cell proliferation (GO:0002053)3.13410788
49embryonic cranial skeleton morphogenesis (GO:0048701)3.10072901
50mesenchyme morphogenesis (GO:0072132)3.09439215
51segment specification (GO:0007379)3.07450658
52regulation of establishment of planar polarity (GO:0090175)3.07402780
53neuron recognition (GO:0008038)3.06737585
54cranial nerve morphogenesis (GO:0021602)3.06127112
55kidney mesenchyme development (GO:0072074)3.06074721
56dermatan sulfate metabolic process (GO:0030205)3.05613938
57endocardial cushion morphogenesis (GO:0003203)3.04656083
58neuron fate determination (GO:0048664)3.04327093
59craniofacial suture morphogenesis (GO:0097094)3.03937084
60positive regulation of neuroblast proliferation (GO:0002052)3.01885543
61multicellular organismal catabolic process (GO:0044243)2.99117627
62hippo signaling (GO:0035329)2.98728373
63multicellular organismal metabolic process (GO:0044236)2.97677839
64extracellular matrix assembly (GO:0085029)2.96634131
65limb bud formation (GO:0060174)2.96359463
66regulation of somitogenesis (GO:0014807)2.96018780
67spinal cord association neuron differentiation (GO:0021527)2.95021813
68peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.94701901
69spinal cord development (GO:0021510)2.94258075
70extracellular matrix disassembly (GO:0022617)2.93427766
71basement membrane organization (GO:0071711)2.92991346
72epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.92942938
73negative regulation of axon guidance (GO:1902668)2.92415725
74regulation of mesenchymal cell proliferation (GO:0010464)2.92099477
75negative regulation of cartilage development (GO:0061037)2.91805268
76regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.89550942
77prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.87205988
78pattern specification involved in kidney development (GO:0061004)2.85897213
79calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.85664849
80paraxial mesoderm development (GO:0048339)2.84673823
81collecting duct development (GO:0072044)2.83906314
82apical protein localization (GO:0045176)2.83106415
83central nervous system projection neuron axonogenesis (GO:0021952)2.82808313
84cell proliferation involved in metanephros development (GO:0072203)2.82024583
85regulation of smoothened signaling pathway (GO:0008589)2.81905924
86negative regulation of axon extension involved in axon guidance (GO:0048843)2.81072341
87astrocyte differentiation (GO:0048708)2.81009864
88regulation of axon guidance (GO:1902667)2.80614999
89negative regulation of smoothened signaling pathway (GO:0045879)2.78977469
90positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.78355261
91extracellular fibril organization (GO:0043206)2.77565542
92regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.77359583
93glomerular basement membrane development (GO:0032836)2.76191471
94notochord development (GO:0030903)2.75283106
95head development (GO:0060322)2.75266544
96regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.74979499
97regulation of heart morphogenesis (GO:2000826)2.73879337
98embryonic body morphogenesis (GO:0010172)2.73725934
99negative chemotaxis (GO:0050919)2.71609741
100lens morphogenesis in camera-type eye (GO:0002089)2.71084729
101keratan sulfate catabolic process (GO:0042340)2.70289657
102negative regulation of oligodendrocyte differentiation (GO:0048715)2.70259437
103cell-cell signaling involved in cell fate commitment (GO:0045168)2.70116740
104blood vessel maturation (GO:0001955)2.70063534
105polarized epithelial cell differentiation (GO:0030859)2.68846740
106developmental induction (GO:0031128)2.68747237
107lung-associated mesenchyme development (GO:0060484)2.67687589
108regulation of catenin import into nucleus (GO:0035412)2.67573238
109negative regulation of fatty acid transport (GO:2000192)2.64185068
110organ induction (GO:0001759)2.63495869
111regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.62235598
112cochlea morphogenesis (GO:0090103)2.60373410
113negative regulation of embryonic development (GO:0045992)2.59666686
114desmosome organization (GO:0002934)2.59198265
115body morphogenesis (GO:0010171)2.57821669
116central nervous system myelination (GO:0022010)2.55832072
117axon ensheathment in central nervous system (GO:0032291)2.55832072
118proximal/distal pattern formation (GO:0009954)2.55605312
119positive regulation of synapse assembly (GO:0051965)2.55280875
120intraciliary transport (GO:0042073)2.55268150
121camera-type eye morphogenesis (GO:0048593)2.54909446
122anatomical structure regression (GO:0060033)2.54641742
123bone morphogenesis (GO:0060349)2.54252091
124convergent extension (GO:0060026)2.54213544
125dorsal/ventral pattern formation (GO:0009953)2.53636114
126retina vasculature morphogenesis in camera-type eye (GO:0061299)2.53245155
127mesenchyme development (GO:0060485)2.53195174
128establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.52664702
129regulation of chondrocyte differentiation (GO:0032330)2.52569417
130establishment of nucleus localization (GO:0040023)2.52288232
131positive regulation of gastrulation (GO:2000543)2.51580076
132dorsal/ventral axis specification (GO:0009950)2.50950605
133regulation of cell fate specification (GO:0042659)2.50834891
134chondrocyte development (GO:0002063)2.50556685
135olfactory bulb development (GO:0021772)2.50244734
136positive regulation of glycogen biosynthetic process (GO:0045725)2.50097162
137negative regulation of astrocyte differentiation (GO:0048712)2.50020311
138regulation of neuroblast proliferation (GO:1902692)2.49741011
139heart valve morphogenesis (GO:0003179)2.48516269
140cell proliferation involved in kidney development (GO:0072111)2.48421709
141regulation of cartilage development (GO:0061035)2.47530916
142positive regulation of smoothened signaling pathway (GO:0045880)2.47189406
143artery development (GO:0060840)2.46662706
144positive regulation of epithelial to mesenchymal transition (GO:0010718)2.46314087
145asymmetric protein localization (GO:0008105)2.45777047
146post-anal tail morphogenesis (GO:0036342)2.45695441
147peripheral nervous system axon ensheathment (GO:0032292)2.45534364
148myelination in peripheral nervous system (GO:0022011)2.45534364
149negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.45116429
150regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.44989838
151inner ear morphogenesis (GO:0042472)2.44671268
152positive regulation of cartilage development (GO:0061036)2.44667589
153mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.44554139
154cell-substrate junction assembly (GO:0007044)2.44376691
155cell migration involved in heart development (GO:0060973)2.43874759
156cellular response to vitamin (GO:0071295)2.42925667
157face morphogenesis (GO:0060325)2.42748326
158substrate-independent telencephalic tangential migration (GO:0021826)2.42110923
159substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.42110923
160positive regulation of vascular permeability (GO:0043117)2.41804040
161axon extension (GO:0048675)2.41583551
162gastrulation with mouth forming second (GO:0001702)2.41556005
163regulation of axon extension involved in axon guidance (GO:0048841)2.41100404
164somatic stem cell division (GO:0048103)2.40414501
165branching involved in salivary gland morphogenesis (GO:0060445)2.39432829
166epithelial cilium movement (GO:0003351)2.39399655
167renal system development (GO:0072001)2.38768014
168metanephric nephron tubule development (GO:0072234)2.38733559
169plasma membrane repair (GO:0001778)2.38456585
170epithelial cell-cell adhesion (GO:0090136)2.37586447
171extracellular matrix organization (GO:0030198)2.36616608

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.01723926
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.54367687
3* EED_16625203_ChIP-ChIP_MESCs_Mouse2.65268892
4* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60793467
5* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60793467
6* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.49272446
7SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.36452098
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.32636361
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.29615099
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.21798305
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.20256123
12ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.19385668
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.17343767
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.12425110
15CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.11025821
16* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.10862151
17* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.10233497
18* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.04841041
19EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.00341432
20EZH2_22144423_ChIP-Seq_EOC_Human1.99944852
21* RNF2_27304074_Chip-Seq_ESCs_Mouse1.98107447
22* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.90096581
23CLOCK_20551151_ChIP-Seq_293T_Human1.88062566
24RBPJ_22232070_ChIP-Seq_NCS_Mouse1.83017312
25* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.82520591
26TP53_20018659_ChIP-ChIP_R1E_Mouse1.80012966
27* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.79217355
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.78096567
29EP300_21415370_ChIP-Seq_HL-1_Mouse1.76591795
30ESR1_21235772_ChIP-Seq_MCF-7_Human1.73135773
31POU5F1_16153702_ChIP-ChIP_HESCs_Human1.72494014
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.70581700
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.69279470
34* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.66592508
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.64275014
36AR_21572438_ChIP-Seq_LNCaP_Human1.59502327
37* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.53161619
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.52994236
39CJUN_26792858_Chip-Seq_BT549_Human1.52873952
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52215692
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.51062268
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49338012
43RNF2_27304074_Chip-Seq_NSC_Mouse1.49014722
44TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.48089505
45DROSHA_22980978_ChIP-Seq_HELA_Human1.46215924
46ISL1_27105846_Chip-Seq_CPCs_Mouse1.46174651
47WT1_19549856_ChIP-ChIP_CCG9911_Human1.44741095
48NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.44670601
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.43586536
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.43020510
51* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.42310122
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.42244502
53* RING1B_27294783_Chip-Seq_ESCs_Mouse1.41654816
54ZFP281_18757296_ChIP-ChIP_E14_Mouse1.40545876
55RING1B_27294783_Chip-Seq_NPCs_Mouse1.37989702
56RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.37842148
57TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.36577912
58* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.36045050
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35658501
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.35348317
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34646716
62AHR_22903824_ChIP-Seq_MCF-7_Human1.34427579
63KDM2B_26808549_Chip-Seq_K562_Human1.34153581
64TP53_18474530_ChIP-ChIP_U2OS_Human1.33979587
65TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.33919180
66TP53_16413492_ChIP-PET_HCT116_Human1.31891685
67DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.29353807
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29321380
69TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28200604
70ARNT_22903824_ChIP-Seq_MCF-7_Human1.26796508
71ZFP281_27345836_Chip-Seq_ESCs_Mouse1.25104612
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24841219
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24841219
74SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24431745
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24343177
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.23022654
77KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22585583
78ESR1_20079471_ChIP-ChIP_T-47D_Human1.21074486
79TBX3_20139965_ChIP-Seq_MESCs_Mouse1.20743063
80TBX3_20139965_ChIP-Seq_ESCs_Mouse1.20385924
81STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17956551
82ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16318281
83IGF1R_20145208_ChIP-Seq_DFB_Human1.15057780
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14895827
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14297224
86CBX2_27304074_Chip-Seq_ESCs_Mouse1.13255513
87STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.12693495
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12236361
89CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11365821
90BRD4_25478319_ChIP-Seq_HGPS_Human1.10028313
91HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09178256
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08514514
93NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08355450
94NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08355450
95ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07784481
96KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07735268
97RXR_22108803_ChIP-Seq_LS180_Human1.07342903
98HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06552681
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.06413098
100SMAD_19615063_ChIP-ChIP_OVARY_Human1.06079778
101VDR_22108803_ChIP-Seq_LS180_Human1.05781262
102SMAD4_21799915_ChIP-Seq_A2780_Human1.05588132
103BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05500256
104GBX2_23144817_ChIP-Seq_PC3_Human1.04886647
105YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04414410
106P300_19829295_ChIP-Seq_ESCs_Human1.03470912
107SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01202425
108ZNF263_19887448_ChIP-Seq_K562_Human1.00886534
109SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00311425
110CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.00231120
111P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00032368
112REST_21632747_ChIP-Seq_MESCs_Mouse0.99918128
113LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99179346
114BCAT_22108803_ChIP-Seq_LS180_Human0.99154419
115TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98480411
116MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97186605
117* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97114883
118PPAR_26484153_Chip-Seq_NCI-H1993_Human0.96187112
119FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95990842
120* SOX9_26525672_Chip-Seq_HEART_Mouse0.95511862
121ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95444621
122TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95021085
123KDM2B_26808549_Chip-Seq_JURKAT_Human0.94970213
124HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94906640
125SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94255329
126AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93980273
127SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.93824573
128UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93206198
129POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.93205388
130TCF4_18268006_ChIP-ChIP_LS174T_Human0.92522178
131CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92470320
132* TBX20_22328084_ChIP-Seq_HEART_Mouse0.92392670
133* TBX20_22080862_ChIP-Seq_HEART_Mouse0.92392670
134* AR_19668381_ChIP-Seq_PC3_Human0.92280425
135SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.91577932
136RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90989787
137SMAD3_21741376_ChIP-Seq_ESCs_Human0.90583908
138GATA1_26923725_Chip-Seq_HPCs_Mouse0.89968340
139CTCF_27219007_Chip-Seq_Bcells_Human0.89681920
140MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89533822
141OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.89427964
142* SOX2_21211035_ChIP-Seq_LN229_Gbm0.89300428
143SOX2_16153702_ChIP-ChIP_HESCs_Human0.89278807
144FUS_26573619_Chip-Seq_HEK293_Human0.88989072
145THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88263402
146SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84470939

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.99535238
2MP0005503_abnormal_tendon_morphology4.82719142
3MP0005275_abnormal_skin_tensile4.44261253
4MP0003705_abnormal_hypodermis_morpholog3.31255423
5MP0006292_abnormal_olfactory_placode3.26155658
6MP0004272_abnormal_basement_membrane3.10062058
7MP0010030_abnormal_orbit_morphology2.74796399
8MP0002653_abnormal_ependyma_morphology2.47862704
9MP0001958_emphysema2.31867038
10MP0005508_abnormal_skeleton_morphology2.24493673
11MP0003136_yellow_coat_color2.23360884
12MP0009250_abnormal_appendicular_skeleto2.18980217
13MP0003279_aneurysm2.18311370
14MP0005623_abnormal_meninges_morphology2.16786987
15MP0002249_abnormal_larynx_morphology2.04545949
16MP0003385_abnormal_body_wall2.02117677
17MP0002108_abnormal_muscle_morphology1.89130464
18MP0009384_cardiac_valve_regurgitation1.88090627
19MP0001293_anophthalmia1.86885044
20MP0002060_abnormal_skin_morphology1.81672618
21MP0000428_abnormal_craniofacial_morphol1.80263879
22MP0000049_abnormal_middle_ear1.79418770
23MP0003942_abnormal_urinary_system1.78334239
24MP0002282_abnormal_trachea_morphology1.77785457
25MP0000537_abnormal_urethra_morphology1.75762846
26MP0005257_abnormal_intraocular_pressure1.74662396
27MP0005499_abnormal_olfactory_system1.73215915
28MP0005394_taste/olfaction_phenotype1.73215915
29MP0000534_abnormal_ureter_morphology1.70354991
30MP0006054_spinal_hemorrhage1.69856969
31MP0009053_abnormal_anal_canal1.68085394
32MP0001299_abnormal_eye_distance/1.65478637
33MP0009379_abnormal_foot_pigmentation1.64212703
34MP0004133_heterotaxia1.63757065
35MP0000762_abnormal_tongue_morphology1.58359094
36MP0000026_abnormal_inner_ear1.50971994
37MP0002932_abnormal_joint_morphology1.50971689
38MP0001849_ear_inflammation1.50475455
39MP0000566_synostosis1.50152271
40MP0002938_white_spotting1.49558136
41MP0003283_abnormal_digestive_organ1.47027428
42MP0004858_abnormal_nervous_system1.45936003
43MP0000163_abnormal_cartilage_morphology1.44807477
44MP0004885_abnormal_endolymph1.44408588
45MP0000733_abnormal_muscle_development1.43814757
46MP0003115_abnormal_respiratory_system1.43778307
47MP0003755_abnormal_palate_morphology1.43724190
48MP0002233_abnormal_nose_morphology1.43051776
49MP0002896_abnormal_bone_mineralization1.42286311
50MP0000516_abnormal_urinary_system1.41867929
51MP0005367_renal/urinary_system_phenotyp1.41867929
52MP0000579_abnormal_nail_morphology1.41532448
53MP0002254_reproductive_system_inflammat1.38525933
54MP0010234_abnormal_vibrissa_follicle1.35605731
55MP0003941_abnormal_skin_development1.32810122
56MP0002115_abnormal_skeleton_extremities1.30531734
57MP0002116_abnormal_craniofacial_bone1.28987197
58MP0003122_maternal_imprinting1.27688615
59MP0003566_abnormal_cell_adhesion1.24090664
60MP0003937_abnormal_limbs/digits/tail_de1.23892270
61MP0003935_abnormal_craniofacial_develop1.23774644
62MP0001984_abnormal_olfaction1.19105698
63MP0002234_abnormal_pharynx_morphology1.18670149
64MP0005076_abnormal_cell_differentiation1.17552650
65MP0004134_abnormal_chest_morphology1.16916694
66MP0000751_myopathy1.16680427
67MP0000631_abnormal_neuroendocrine_gland1.16034411
68MP0001270_distended_abdomen1.15222048
69MP0001286_abnormal_eye_development1.12301996
70MP0009780_abnormal_chondrocyte_physiolo1.10763960
71MP0002109_abnormal_limb_morphology1.10350461
72MP0003861_abnormal_nervous_system1.10323666
73MP0000383_abnormal_hair_follicle1.09338331
74MP0000432_abnormal_head_morphology1.09331399
75MP0002638_abnormal_pupillary_reflex1.08420012
76MP0005391_vision/eye_phenotype1.06588761
77MP0002295_abnormal_pulmonary_circulatio1.06536456
78MP0005023_abnormal_wound_healing1.04405116
79MP0004859_abnormal_synaptic_plasticity1.04351681
80MP0010678_abnormal_skin_adnexa1.02093643
81MP0006072_abnormal_retinal_apoptosis1.00672459
82MP0003121_genomic_imprinting1.00633295
83MP0000955_abnormal_spinal_cord0.98860982
84MP0001346_abnormal_lacrimal_gland0.98837735
85MP0001485_abnormal_pinna_reflex0.98557163
86MP0010368_abnormal_lymphatic_system0.96197969
87MP0001177_atelectasis0.96003380
88MP0002102_abnormal_ear_morphology0.95517407
89MP0008789_abnormal_olfactory_epithelium0.94687057
90MP0000767_abnormal_smooth_muscle0.94067006
91MP0002113_abnormal_skeleton_development0.93574068
92MP0002089_abnormal_postnatal_growth/wei0.92591865
93MP0003119_abnormal_digestive_system0.91689761
94MP0005390_skeleton_phenotype0.90919338
95MP0005187_abnormal_penis_morphology0.90683784
96MP0002114_abnormal_axial_skeleton0.90296820
97MP0002752_abnormal_somatic_nervous0.90263916
98MP0002152_abnormal_brain_morphology0.89929440
99MP0003045_fibrosis0.88971486
100MP0002177_abnormal_outer_ear0.87837539
101MP0005248_abnormal_Harderian_gland0.87391953
102MP0003091_abnormal_cell_migration0.87201377
103MP0002111_abnormal_tail_morphology0.87053225
104MP0003011_delayed_dark_adaptation0.86272419
105MP0000013_abnormal_adipose_tissue0.85988232
106MP0005195_abnormal_posterior_eye0.85970796
107MP0001340_abnormal_eyelid_morphology0.84652318
108MP0001879_abnormal_lymphatic_vessel0.83638676
109MP0005253_abnormal_eye_physiology0.83571201
110MP0003880_abnormal_central_pattern0.80855653
111MP0005377_hearing/vestibular/ear_phenot0.80845319
112MP0003878_abnormal_ear_physiology0.80845319
113MP0000467_abnormal_esophagus_morphology0.79790558
114MP0000462_abnormal_digestive_system0.77615659
115MP0006276_abnormal_autonomic_nervous0.77506402
116MP0001529_abnormal_vocalization0.77491640
117MP0001502_abnormal_circadian_rhythm0.76262508
118MP0000678_abnormal_parathyroid_gland0.75848676
119MP0002882_abnormal_neuron_morphology0.75626138
120MP0005171_absent_coat_pigmentation0.75565517
121MP0003938_abnormal_ear_development0.75460813
122MP0002557_abnormal_social/conspecific_i0.75435311
123MP0002092_abnormal_eye_morphology0.74099434
124MP0002697_abnormal_eye_size0.73154525
125* MP0002184_abnormal_innervation0.72738493
126MP0004145_abnormal_muscle_electrophysio0.72666811
127MP0002081_perinatal_lethality0.71760373
128MP0001963_abnormal_hearing_physiology0.71430981
129MP0010771_integument_phenotype0.70538136
130MP0001243_abnormal_dermal_layer0.69955430
131MP0002098_abnormal_vibrissa_morphology0.68116824
132MP0000003_abnormal_adipose_tissue0.68092628
133MP0002925_abnormal_cardiovascular_devel0.67972451
134MP0001486_abnormal_startle_reflex0.67518658
135MP0003787_abnormal_imprinting0.67354744
136MP0002133_abnormal_respiratory_system0.66220532
137MP0005388_respiratory_system_phenotype0.66220532
138MP0002168_other_aberrant_phenotype0.65303774
139MP0000778_abnormal_nervous_system0.61593659

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.52134935
2Premature rupture of membranes (HP:0001788)5.28608137
3Shallow orbits (HP:0000586)5.11164674
4Broad metatarsal (HP:0001783)4.97160501
5Ankle contracture (HP:0006466)4.21865641
6Atrophic scars (HP:0001075)4.15646927
7Aortic dissection (HP:0002647)3.55537698
8Rib fusion (HP:0000902)3.37057364
9Bladder diverticulum (HP:0000015)3.22351931
10Follicular hyperkeratosis (HP:0007502)3.19500791
11Neonatal short-limb short stature (HP:0008921)3.16521708
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.15704134
13Short 4th metacarpal (HP:0010044)3.15704134
14Fragile skin (HP:0001030)3.00023808
15Septo-optic dysplasia (HP:0100842)2.97726932
16Soft skin (HP:0000977)2.95122386
17Vitreoretinal degeneration (HP:0000655)2.90616726
18Aortic aneurysm (HP:0004942)2.89391281
19Cerebral aneurysm (HP:0004944)2.86108939
20Cutaneous syndactyly (HP:0012725)2.84898304
21Type 1 muscle fiber predominance (HP:0003803)2.84797784
22Abnormality of the 4th metacarpal (HP:0010012)2.74609739
23Abnormality of the ischium (HP:0003174)2.72620721
24Cervical subluxation (HP:0003308)2.67833349
25Spinal rigidity (HP:0003306)2.61177993
26Dilatation of the ascending aorta (HP:0005111)2.59578675
27Mitral valve prolapse (HP:0001634)2.58894967
28Hypoplastic ischia (HP:0003175)2.58843184
29Abnormality of dentin (HP:0010299)2.56071338
30Synostosis of carpal bones (HP:0005048)2.52082729
31Coronal craniosynostosis (HP:0004440)2.45669495
32Tracheomalacia (HP:0002779)2.42564958
33Blue sclerae (HP:0000592)2.41233545
34True hermaphroditism (HP:0010459)2.39119540
35Wrist flexion contracture (HP:0001239)2.38527497
36Aplasia of the phalanges of the hand (HP:0009802)2.36483725
37Aplasia involving bones of the extremities (HP:0009825)2.36483725
38Aplasia involving bones of the upper limbs (HP:0009823)2.36483725
39Bronchomalacia (HP:0002780)2.34386574
40Abnormality of the diencephalon (HP:0010662)2.32332735
41Wormian bones (HP:0002645)2.31650251
42Hyperextensible skin (HP:0000974)2.31394498
43Bell-shaped thorax (HP:0001591)2.31040184
44Broad ribs (HP:0000885)2.28850327
45Preaxial foot polydactyly (HP:0001841)2.28555066
46Deviation of the hallux (HP:0010051)2.26415455
47Increased connective tissue (HP:0009025)2.26384490
48Milia (HP:0001056)2.25617904
49Fibular hypoplasia (HP:0003038)2.23197755
50High anterior hairline (HP:0009890)2.22173628
51Pancreatic fibrosis (HP:0100732)2.21813369
52Partial duplication of thumb phalanx (HP:0009944)2.21048202
53Genu recurvatum (HP:0002816)2.20210858
54Abdominal situs inversus (HP:0003363)2.20008882
55Abnormality of abdominal situs (HP:0011620)2.20008882
56Partial duplication of the phalanx of hand (HP:0009999)2.19980535
57Abnormality of the aortic arch (HP:0012303)2.19806721
58Wide anterior fontanel (HP:0000260)2.19689696
59Overgrowth (HP:0001548)2.16258945
60Infantile muscular hypotonia (HP:0008947)2.15841526
61Joint laxity (HP:0001388)2.15521762
62Renal dysplasia (HP:0000110)2.14810089
63Mildly elevated creatine phosphokinase (HP:0008180)2.14605251
64Broad long bones (HP:0005622)2.13096871
65Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.11526182
66Bowel diverticulosis (HP:0005222)2.10526183
67Flat cornea (HP:0007720)2.09068405
68Increased variability in muscle fiber diameter (HP:0003557)2.08289863
69Renal duplication (HP:0000075)2.08024220
70Mesomelia (HP:0003027)2.06583908
71Camptodactyly of toe (HP:0001836)2.06301670
72Morphological abnormality of the middle ear (HP:0008609)2.04480182
73Oligodactyly (HP:0012165)2.03812834
74Hallux valgus (HP:0001822)2.03356647
75Narrow nasal bridge (HP:0000446)2.02777385
76Vascular tortuosity (HP:0004948)2.02605020
77Elbow flexion contracture (HP:0002987)2.00343951
78Carpal synostosis (HP:0009702)1.98748215
79Slender build (HP:0001533)1.97798994
80Scapular winging (HP:0003691)1.97712528
81Turricephaly (HP:0000262)1.97579044
82Buphthalmos (HP:0000557)1.97225337
83Broad toe (HP:0001837)1.97002886
84Mitral regurgitation (HP:0001653)1.96526242
85Short hallux (HP:0010109)1.94250751
86Abnormality of the middle phalanges of the toes (HP:0010183)1.92674542
87Thin bony cortex (HP:0002753)1.92089963
88Peritonitis (HP:0002586)1.91092192
89Broad phalanx (HP:0006009)1.90268087
90Tarsal synostosis (HP:0008368)1.89729314
91Abnormality of midbrain morphology (HP:0002418)1.89052461
92Molar tooth sign on MRI (HP:0002419)1.89052461
93Optic nerve hypoplasia (HP:0000609)1.88432262
94Asymmetry of the thorax (HP:0001555)1.88386698
95Thin ribs (HP:0000883)1.88358564
96Cystic liver disease (HP:0006706)1.88254699
97Anophthalmia (HP:0000528)1.88165801
98Aplasia/Hypoplasia of the tongue (HP:0010295)1.86974683
99Calcaneovalgus deformity (HP:0001848)1.85875821
100Mixed hearing impairment (HP:0000410)1.84771352
101Postaxial foot polydactyly (HP:0001830)1.84645529
102Hypoplasia of the iris (HP:0007676)1.84274589
103Sprengel anomaly (HP:0000912)1.84273839
104Broad thumb (HP:0011304)1.84126281
105Enlarged penis (HP:0000040)1.82116203
106Bifid tongue (HP:0010297)1.81823507
107Arterial tortuosity (HP:0005116)1.81742823
108Broad hallux (HP:0010055)1.81693910
109Nephronophthisis (HP:0000090)1.81079849
110Alacrima (HP:0000522)1.80696317
111Down-sloping shoulders (HP:0200021)1.79238586
112Selective tooth agenesis (HP:0001592)1.79211813
113Aneurysm (HP:0002617)1.79117595
114Biconcave vertebral bodies (HP:0004586)1.79025645
115Renal hypoplasia (HP:0000089)1.78339283
116Fragile nails (HP:0001808)1.77534205
117Aplasia/Hypoplasia of the fibula (HP:0006492)1.77244231
118Disproportionate tall stature (HP:0001519)1.76480427
119Broad finger (HP:0001500)1.76451346
120Vertebral hypoplasia (HP:0008417)1.76050678
121Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.76050678
122Limited hip movement (HP:0008800)1.76047181
123Maternal diabetes (HP:0009800)1.75958894
124Vertebral compression fractures (HP:0002953)1.75369480
125Supernumerary ribs (HP:0005815)1.75182614
126Natal tooth (HP:0000695)1.75171684
127Postaxial hand polydactyly (HP:0001162)1.74805924
128Hip contracture (HP:0003273)1.74111616
129Midline defect of the nose (HP:0004122)1.72974106
130Ulnar bowing (HP:0003031)1.72897222
131Hemivertebrae (HP:0002937)1.72627956
132Broad phalanges of the hand (HP:0009768)1.72621970
133Supernumerary spleens (HP:0009799)1.72608805
134Tented upper lip vermilion (HP:0010804)1.72497305
135Right ventricular cardiomyopathy (HP:0011663)1.72459165
136Osteoarthritis (HP:0002758)1.72392481
137Synostosis involving bones of the lower limbs (HP:0009138)1.71959017
138Synostosis involving bones of the feet (HP:0009140)1.71959017
139Hypoventilation (HP:0002791)1.71546790
140Aplasia/Hypoplasia of the hallux (HP:0008362)1.71406642
141Missing ribs (HP:0000921)1.71009975
142Advanced eruption of teeth (HP:0006288)1.70571456
143Deformed tarsal bones (HP:0008119)1.70279487
144Trigonocephaly (HP:0000243)1.68827295
145Increased corneal curvature (HP:0100692)1.68128236
146Keratoconus (HP:0000563)1.68128236
147Abnormality of skeletal muscle fiber size (HP:0012084)1.67722322
148Ectopia lentis (HP:0001083)1.67662019
149Abnormality of the calcaneus (HP:0008364)1.67641828
150Microglossia (HP:0000171)1.66814041
151Hepatoblastoma (HP:0002884)1.66421179
152Humeroradial synostosis (HP:0003041)1.66203374
153Synostosis involving the elbow (HP:0003938)1.66203374
154Cutaneous finger syndactyly (HP:0010554)1.65684662
155Supernumerary bones of the axial skeleton (HP:0009144)1.63727544
156Hypoplasia of the ulna (HP:0003022)1.63607380
157Pancreatic cysts (HP:0001737)1.63092323
158Pulmonary artery stenosis (HP:0004415)1.63079862
159Occipital encephalocele (HP:0002085)1.61892724

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.87737325
2SIK14.01619664
3LATS13.71523388
4TRIB33.41163566
5EPHB23.34781364
6PDGFRA3.19091438
7RIPK13.09573800
8LATS22.37645722
9EPHA42.31589219
10TTN2.29511049
11MARK12.15683857
12EPHA32.11113847
13FER2.08606850
14FGFR22.05503218
15TNIK1.78880127
16DYRK21.70376496
17PTK61.70293472
18INSRR1.61864798
19MOS1.60431625
20FGFR11.56208594
21PRKD31.52220419
22CAMK1G1.50622742
23ERN11.50085216
24BMX1.49371323
25ERBB31.42359834
26PINK11.40389744
27CAMK1D1.39476299
28WNK41.37066466
29PAK21.36375913
30DAPK21.33799699
31PKN21.33012429
32MAP3K41.30416522
33LMTK21.30041670
34PNCK1.28948292
35PTK21.24536645
36STK391.19092400
37STK381.12906672
38TGFBR11.11756674
39PDGFRB1.09825070
40DMPK1.09635527
41WNK31.05836213
42EEF2K1.05218325
43BCR1.02183313
44WNK11.01492295
45EPHB11.01097024
46ERBB20.99682851
47NTRK10.99143429
48DYRK1B0.98732909
49ROCK10.98224300
50PLK20.97432679
51TGFBR20.96994384
52CDK190.96280729
53FGFR30.95575280
54MAPK70.95441309
55PAK30.93484670
56PAK40.91409160
57STK30.90971542
58MYLK0.89753079
59PRKCH0.88095829
60MAP4K20.87374829
61MAPK150.86824721
62TYRO30.86041147
63PAK60.84731167
64CAMKK10.83626144
65PTK2B0.83255469
66MTOR0.83182219
67GRK10.82056410
68CAMK10.81670315
69MAP2K70.81442178
70RET0.79893906
71ROCK20.79784024
72FGFR40.78604761
73MAP3K100.77752851
74LRRK20.76642140
75CDC42BPA0.76141047
76PRKD20.74515695
77SGK2230.72948525
78SGK4940.72948525
79PIK3CA0.72421151
80RPS6KA60.70265703
81NEK20.70162139
82RPS6KC10.69749053
83RPS6KL10.69749053
84MAP3K20.69262100
85STK38L0.67787637
86PRKD10.66750129
87MAP2K10.66564631
88PHKG10.66192363
89PHKG20.66192363
90DYRK1A0.65257984
91STK110.65152173
92NTRK20.63977177
93NEK90.61366691
94MKNK20.60668168
95RPS6KA20.60609577
96CAMKK20.60464878
97CDK30.57927545
98BMPR1B0.57460981
99MET0.57305514
100FRK0.57101007
101PRKCG0.57013995
102MAPK130.56625771
103SGK30.56319148
104KSR10.55842451
105BCKDK0.53322288
106ICK0.53144762
107PKN10.53054268
108MAP2K40.52027346
109CDK11A0.50881336
110MKNK10.50670345
111SRC0.50552030
112UHMK10.49205279
113ILK0.48937498
114DYRK30.48644176
115CDK150.47832673
116SIK20.47685294
117CDK50.47078738
118CAMK40.46742839
119CSNK1G20.46071995
120TIE10.45993302
121CSNK1G10.44190934
122GSK3A0.43841984
123MATK0.43703537
124ADRBK10.43602009
125PRKCE0.43547755
126CDK180.43417038
127JAK10.43242098
128NTRK30.42945119
129MAP3K70.41241785
130MAP3K30.38887828
131CDK60.38207948
132TAOK10.37197866
133SGK20.35852897
134RPS6KB20.35164662
135TRPM70.35114125
136DAPK30.33565350
137INSR0.30354795
138MAPK10.27943305
139MINK10.27633908
140CASK0.26986729
141ALK0.26074993
142AKT30.25671417
143MST1R0.25658006
144MAPK80.24450531
145MARK20.23807579

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.35892926
2Basal cell carcinoma_Homo sapiens_hsa052172.71887406
3Protein digestion and absorption_Homo sapiens_hsa049742.30731288
4Focal adhesion_Homo sapiens_hsa045102.26492821
5Hedgehog signaling pathway_Homo sapiens_hsa043402.24642908
6Hippo signaling pathway_Homo sapiens_hsa043902.05855625
7Proteoglycans in cancer_Homo sapiens_hsa052052.00132880
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.94383979
9Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.87618367
10Adherens junction_Homo sapiens_hsa045201.77053800
11Steroid biosynthesis_Homo sapiens_hsa001001.75095637
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.64027861
13Amoebiasis_Homo sapiens_hsa051461.63312753
14AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.62102126
15TGF-beta signaling pathway_Homo sapiens_hsa043501.61499154
16Dilated cardiomyopathy_Homo sapiens_hsa054141.61167665
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.59143135
18Melanogenesis_Homo sapiens_hsa049161.55917096
19Axon guidance_Homo sapiens_hsa043601.52960386
20Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.48016708
21Wnt signaling pathway_Homo sapiens_hsa043101.43849361
22Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.43274048
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.40993849
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34949815
25Notch signaling pathway_Homo sapiens_hsa043301.33714759
26Bladder cancer_Homo sapiens_hsa052191.33261441
27Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.33144876
28Gastric acid secretion_Homo sapiens_hsa049711.28635841
29Small cell lung cancer_Homo sapiens_hsa052221.27138964
30Estrogen signaling pathway_Homo sapiens_hsa049151.26010397
31Phototransduction_Homo sapiens_hsa047441.23607156
32Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.22648921
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.22364744
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.17692322
35PI3K-Akt signaling pathway_Homo sapiens_hsa041511.17144854
36Melanoma_Homo sapiens_hsa052181.13909429
37Salivary secretion_Homo sapiens_hsa049701.13046568
38Glioma_Homo sapiens_hsa052141.12806521
39MicroRNAs in cancer_Homo sapiens_hsa052061.12790870
40Tight junction_Homo sapiens_hsa045301.12579901
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.12571442
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09740254
43Endometrial cancer_Homo sapiens_hsa052131.08343131
44Propanoate metabolism_Homo sapiens_hsa006401.07999224
45Pathways in cancer_Homo sapiens_hsa052001.07197115
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06140256
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05935909
48Thyroid hormone synthesis_Homo sapiens_hsa049181.05254318
49Rap1 signaling pathway_Homo sapiens_hsa040151.03134626
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01231562
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00947896
52GnRH signaling pathway_Homo sapiens_hsa049121.00755061
53Thyroid hormone signaling pathway_Homo sapiens_hsa049191.00256178
54Prostate cancer_Homo sapiens_hsa052150.99794461
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99601761
56Chronic myeloid leukemia_Homo sapiens_hsa052200.98568632
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97193456
58Circadian entrainment_Homo sapiens_hsa047130.95974772
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95929315
60Dorso-ventral axis formation_Homo sapiens_hsa043200.93046141
61Amphetamine addiction_Homo sapiens_hsa050310.92129895
62Renin secretion_Homo sapiens_hsa049240.91411916
63Gap junction_Homo sapiens_hsa045400.90918906
64Long-term potentiation_Homo sapiens_hsa047200.90885173
65Insulin resistance_Homo sapiens_hsa049310.89064106
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.88615233
67Cardiac muscle contraction_Homo sapiens_hsa042600.86970807
68Colorectal cancer_Homo sapiens_hsa052100.86454781
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85999413
70Morphine addiction_Homo sapiens_hsa050320.85866817
71cAMP signaling pathway_Homo sapiens_hsa040240.85352193
72Oxytocin signaling pathway_Homo sapiens_hsa049210.85169358
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.84423332
74mTOR signaling pathway_Homo sapiens_hsa041500.84111489
75Glutamatergic synapse_Homo sapiens_hsa047240.84051691
76Type II diabetes mellitus_Homo sapiens_hsa049300.83191432
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81821748
78Pancreatic cancer_Homo sapiens_hsa052120.80983547
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80218869
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.79820198
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79734688
82Nitrogen metabolism_Homo sapiens_hsa009100.78799479
83Ribosome_Homo sapiens_hsa030100.78764504
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78515948
85Long-term depression_Homo sapiens_hsa047300.77358347
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.75582984
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75170181
88Fatty acid biosynthesis_Homo sapiens_hsa000610.74811430
89Nicotine addiction_Homo sapiens_hsa050330.74659139
90Toxoplasmosis_Homo sapiens_hsa051450.73789951
91Insulin secretion_Homo sapiens_hsa049110.73261472
92Cocaine addiction_Homo sapiens_hsa050300.73152703
93ErbB signaling pathway_Homo sapiens_hsa040120.73087691
94Taste transduction_Homo sapiens_hsa047420.70918363
95GABAergic synapse_Homo sapiens_hsa047270.70277996
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.70200282
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.69014990
98beta-Alanine metabolism_Homo sapiens_hsa004100.67712823
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67268233
100Lysine degradation_Homo sapiens_hsa003100.66807796
101Renal cell carcinoma_Homo sapiens_hsa052110.66397367
102AMPK signaling pathway_Homo sapiens_hsa041520.65692904
103Dopaminergic synapse_Homo sapiens_hsa047280.65044179
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.64554376
105Cholinergic synapse_Homo sapiens_hsa047250.63946304
106Insulin signaling pathway_Homo sapiens_hsa049100.63902824
107Sulfur relay system_Homo sapiens_hsa041220.63708102
108Circadian rhythm_Homo sapiens_hsa047100.63285046
109Linoleic acid metabolism_Homo sapiens_hsa005910.62999260
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62818783
111HTLV-I infection_Homo sapiens_hsa051660.62492016
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61116824
113MAPK signaling pathway_Homo sapiens_hsa040100.61003467
114Viral myocarditis_Homo sapiens_hsa054160.59779875
115Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59598592
116Butanoate metabolism_Homo sapiens_hsa006500.59571915
117Calcium signaling pathway_Homo sapiens_hsa040200.57579115
118Malaria_Homo sapiens_hsa051440.57347210
119Platelet activation_Homo sapiens_hsa046110.55891836
120Ras signaling pathway_Homo sapiens_hsa040140.55489229
121Ovarian steroidogenesis_Homo sapiens_hsa049130.54821685
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.53331446
123TNF signaling pathway_Homo sapiens_hsa046680.52212036
124Bile secretion_Homo sapiens_hsa049760.50588672
125Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46477431
126Glycerolipid metabolism_Homo sapiens_hsa005610.43011336
127Choline metabolism in cancer_Homo sapiens_hsa052310.42783619
128Ether lipid metabolism_Homo sapiens_hsa005650.40305348
129Glycosaminoglycan degradation_Homo sapiens_hsa005310.38129343
130Arginine and proline metabolism_Homo sapiens_hsa003300.37916671
131Olfactory transduction_Homo sapiens_hsa047400.37551824

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