BOD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1meiotic cell cycle (GO:0051321)5.87651000
2protein localization to chromosome, centromeric region (GO:0071459)5.30711749
3regulation of histone H3-K9 methylation (GO:0051570)5.22644603
4protein localization to kinetochore (GO:0034501)5.17989464
5regulation of acrosome reaction (GO:0060046)4.98902228
6positive regulation of histone H3-K4 methylation (GO:0051571)4.77678103
7negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.61358933
8negative regulation of histone methylation (GO:0031061)4.44902688
9DNA methylation involved in gamete generation (GO:0043046)4.32251827
10female gamete generation (GO:0007292)4.30303114
11oocyte development (GO:0048599)4.27987222
12negative regulation of potassium ion transmembrane transport (GO:1901380)4.24980267
13retinal cone cell development (GO:0046549)4.20969958
14positive regulation of chromosome segregation (GO:0051984)4.19255635
15CENP-A containing nucleosome assembly (GO:0034080)4.18451162
16regulation of cell maturation (GO:1903429)4.12465376
17metaphase plate congression (GO:0051310)4.09946842
18establishment of chromosome localization (GO:0051303)4.04642825
19chromatin remodeling at centromere (GO:0031055)4.03783381
20plasma membrane repair (GO:0001778)3.98727725
21positive regulation of mitotic sister chromatid separation (GO:1901970)3.95273121
22positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.95273121
23positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.95273121
24positive regulation of gastrulation (GO:2000543)3.86196529
25regulation of steroid hormone secretion (GO:2000831)3.80873955
26protein localization to chromosome (GO:0034502)3.75867851
27regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.74761943
28regulation of spindle organization (GO:0090224)3.72285554
29gene silencing by RNA (GO:0031047)3.69415668
30negative regulation of reproductive process (GO:2000242)3.65630306
31attachment of spindle microtubules to kinetochore (GO:0008608)3.64786889
32DNA replication checkpoint (GO:0000076)3.62354932
33synapsis (GO:0007129)3.60119662
34sarcomere organization (GO:0045214)3.57774289
35chromatin assembly (GO:0031497)3.56792198
36actin-myosin filament sliding (GO:0033275)3.53878021
37muscle filament sliding (GO:0030049)3.53878021
38positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.52556503
39multicellular organism reproduction (GO:0032504)3.49507930
40primitive streak formation (GO:0090009)3.49448455
41chromosome organization involved in meiosis (GO:0070192)3.49044886
42paraxial mesoderm development (GO:0048339)3.46254724
43regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.45402007
44DNA replication-independent nucleosome organization (GO:0034724)3.43195199
45DNA replication-independent nucleosome assembly (GO:0006336)3.43195199
46cardiac myofibril assembly (GO:0055003)3.38996648
47chromatin assembly or disassembly (GO:0006333)3.38958798
48histone exchange (GO:0043486)3.38567892
49DNA replication-dependent nucleosome assembly (GO:0006335)3.33789841
50DNA replication-dependent nucleosome organization (GO:0034723)3.33789841
51nuclear pore organization (GO:0006999)3.30647866
52centriole replication (GO:0007099)3.30602224
53positive regulation of histone methylation (GO:0031062)3.29165133
54translesion synthesis (GO:0019985)3.28326449
55regulation of spindle checkpoint (GO:0090231)3.18313434
56regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.17642021
57chromosome condensation (GO:0030261)3.11243137
58regulation of hippo signaling (GO:0035330)3.11129518
59glycine transport (GO:0015816)3.11053549
60tricarboxylic acid cycle (GO:0006099)3.10351237
61myofibril assembly (GO:0030239)3.10192447
62piRNA metabolic process (GO:0034587)3.09061112
63regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.07939404
64sarcoplasmic reticulum calcium ion transport (GO:0070296)3.07223341
65cardiac muscle cell development (GO:0055013)3.07070671
66DNA strand elongation (GO:0022616)3.03032175
67binding of sperm to zona pellucida (GO:0007339)3.02109329
68DNA strand elongation involved in DNA replication (GO:0006271)3.01646869
69actin-mediated cell contraction (GO:0070252)2.98201651
70DNA damage induced protein phosphorylation (GO:0006975)2.97739146
71regulation of skeletal muscle contraction (GO:0014819)2.94501018
72regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.94079539
73regulation of histone methylation (GO:0031060)2.92702685
74regulation of membrane repolarization (GO:0060306)2.92353494
75meiotic cell cycle process (GO:1903046)2.90041378
76cardiac muscle contraction (GO:0060048)2.89931788
77regulation of histone H3-K4 methylation (GO:0051569)2.89342170
78protein kinase C signaling (GO:0070528)2.87536192
79male meiosis I (GO:0007141)2.87355666
80nuclear pore complex assembly (GO:0051292)2.87052335
81positive regulation of DNA-dependent DNA replication (GO:2000105)2.86877025
82telomere maintenance via semi-conservative replication (GO:0032201)2.85645110
83cardiac cell development (GO:0055006)2.83704335
84regulation of RNA export from nucleus (GO:0046831)2.80764462
85ventricular cardiac muscle cell action potential (GO:0086005)2.80193649
86regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.78864156
87notochord development (GO:0030903)2.77600934
88cell migration in hindbrain (GO:0021535)2.75404342
89positive regulation of reproductive process (GO:2000243)2.74611389
90striated muscle contraction (GO:0006941)2.74497586
91nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.73846253
92regulation of meiosis (GO:0040020)2.73195310
93positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.72942791
94sister chromatid cohesion (GO:0007062)2.70876902
95regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.70582107
96meiotic nuclear division (GO:0007126)2.70232795
97regulation of cell cycle G2/M phase transition (GO:1902749)2.69359146
98regulation of mitotic spindle organization (GO:0060236)2.66700953
99regulation of steroid hormone biosynthetic process (GO:0090030)2.66632242
100regulation of acyl-CoA biosynthetic process (GO:0050812)2.65640742
101regulation of chromosome segregation (GO:0051983)2.65576155
102base-excision repair (GO:0006284)2.64899639
103DNA alkylation (GO:0006305)2.64780239
104DNA methylation (GO:0006306)2.64780239
105regulation of chromatin silencing (GO:0031935)2.64182429
106regulation of double-strand break repair via homologous recombination (GO:0010569)2.63879695
107positive regulation of cytokinesis (GO:0032467)2.63667155
108DNA packaging (GO:0006323)2.63619451
109respiratory system process (GO:0003016)2.63526027
110gene silencing (GO:0016458)2.62650288
111nucleotide-excision repair, DNA gap filling (GO:0006297)2.62616845
112kinetochore organization (GO:0051383)2.62367854
113positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.60428186
114positive regulation of cell cycle G2/M phase transition (GO:1902751)2.60428186
115somite rostral/caudal axis specification (GO:0032525)2.59437328
116mitotic G2/M transition checkpoint (GO:0044818)2.58049899
117stress granule assembly (GO:0034063)2.57759372
118oogenesis (GO:0048477)2.57496395
119regulation of meiosis I (GO:0060631)2.56819969
120skeletal muscle contraction (GO:0003009)2.56796980
121fertilization (GO:0009566)2.55633043
122cell communication by electrical coupling (GO:0010644)2.54586898
123mitotic metaphase plate congression (GO:0007080)2.54358830
124ventricular cardiac muscle cell development (GO:0055015)2.53651320
125microtubule severing (GO:0051013)2.53053419
126negative regulation of potassium ion transport (GO:0043267)2.52655624
127regulation of cofactor metabolic process (GO:0051193)2.50132336
128regulation of coenzyme metabolic process (GO:0051196)2.50132336
129cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.49799190
130response to pheromone (GO:0019236)2.48765845
131histone H2A monoubiquitination (GO:0035518)2.46781393
132regulation of short-term neuronal synaptic plasticity (GO:0048172)2.46138828
133positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.44718909
134cytoplasmic microtubule organization (GO:0031122)2.44100519
135carnitine shuttle (GO:0006853)2.43122437
136regulation of cardioblast differentiation (GO:0051890)2.41609513
137regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.39444964
138mitochondrial fusion (GO:0008053)2.37417744
139histone H2A ubiquitination (GO:0033522)2.37086676
140cell communication involved in cardiac conduction (GO:0086065)2.36491945
141neuronal action potential propagation (GO:0019227)2.32839042
142actomyosin structure organization (GO:0031032)2.31986470
143regulation of sulfur metabolic process (GO:0042762)2.31633804
144cardiac muscle cell action potential involved in contraction (GO:0086002)2.29747957
145regulation of early endosome to late endosome transport (GO:2000641)2.28730612
146positive regulation of sodium ion transport (GO:0010765)2.27370931
147layer formation in cerebral cortex (GO:0021819)2.26638688
148establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.26483852
149mitochondrion transport along microtubule (GO:0047497)2.26483852
150regulation of synaptic vesicle transport (GO:1902803)2.25477749
151pre-miRNA processing (GO:0031054)2.25204479
152regulation of DNA methylation (GO:0044030)2.24851081
153negative regulation of organelle assembly (GO:1902116)2.24600601
154synaptonemal complex organization (GO:0070193)2.24367048
155regulation of potassium ion transmembrane transporter activity (GO:1901016)2.24299264
156cardiac muscle cell action potential (GO:0086001)2.24101927
157muscle cell cellular homeostasis (GO:0046716)2.23098243
158regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.22773203
159heart trabecula formation (GO:0060347)2.20859225
160chaperone-mediated protein transport (GO:0072321)2.20356172
161mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.20285115
162protein K6-linked ubiquitination (GO:0085020)2.20044144
163negative regulation of cell size (GO:0045792)2.16554193
164actin filament-based movement (GO:0030048)2.15970887
165membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.15647141
166NADH metabolic process (GO:0006734)2.15408115
167mitotic chromosome condensation (GO:0007076)2.14672996
168regulation of corticosteroid hormone secretion (GO:2000846)2.14145081
169regulation of potassium ion transmembrane transport (GO:1901379)2.12626010
170regulation of female gonad development (GO:2000194)2.12609186
171regulation of meiotic cell cycle (GO:0051445)2.12200093
172striated muscle cell development (GO:0055002)2.10754581
173regulation of synaptic vesicle exocytosis (GO:2000300)2.10692380
174synaptonemal complex assembly (GO:0007130)2.08813016
175regulation of sodium ion transmembrane transporter activity (GO:2000649)2.08068061
176regulation of clathrin-mediated endocytosis (GO:2000369)2.07826731
177carnitine transport (GO:0015879)2.07106740
178amino-acid betaine transport (GO:0015838)2.07106740
179male meiosis (GO:0007140)2.06782064
180skeletal muscle fiber development (GO:0048741)2.06237879
181energy coupled proton transport, down electrochemical gradient (GO:0015985)2.05279203
182ATP synthesis coupled proton transport (GO:0015986)2.05279203
183embryonic foregut morphogenesis (GO:0048617)2.05028217
184muscle contraction (GO:0006936)2.04450111
185response to parathyroid hormone (GO:0071107)2.03844414
186positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.02237695
187labyrinthine layer development (GO:0060711)2.02081265

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.47936373
2EZH2_22144423_ChIP-Seq_EOC_Human4.24246607
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.55219687
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.55219687
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.55219687
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.92002114
7ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.82719804
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.70249943
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.61804881
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.49885280
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.43945633
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.29089105
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.27817788
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.26431200
15ESR1_15608294_ChIP-ChIP_MCF-7_Human2.17687624
16ZNF263_19887448_ChIP-Seq_K562_Human2.17617717
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.14689147
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.07094413
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.00435320
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.96001809
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.91720692
22TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.89625932
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.81305396
24KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.75415212
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72831749
26ZFP281_18757296_ChIP-ChIP_E14_Mouse1.72152616
27NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.69833895
28SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.67042127
29POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64429456
30ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.64046269
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.62302158
32KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.61986572
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.58529670
34PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.54846385
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53373496
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.52852696
37RARB_27405468_Chip-Seq_BRAIN_Mouse1.51558119
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.50872847
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.50013357
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.49865657
41ZNF274_21170338_ChIP-Seq_K562_Hela1.49184417
42NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48726155
43ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.46363540
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45402544
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.43750919
46ESR1_20079471_ChIP-ChIP_T-47D_Human1.40498419
47FOXM1_23109430_ChIP-Seq_U2OS_Human1.38632256
48RNF2_18974828_ChIP-Seq_MESCs_Mouse1.38171037
49EZH2_18974828_ChIP-Seq_MESCs_Mouse1.38171037
50MYC_18358816_ChIP-ChIP_MESCs_Mouse1.36619024
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.35241403
52NANOG_21062744_ChIP-ChIP_HESCs_Human1.35214909
53WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32248875
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.32245042
55KDM2B_26808549_Chip-Seq_K562_Human1.31355898
56JARID2_20064375_ChIP-Seq_MESCs_Mouse1.30881486
57* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.29938840
58RNF2_27304074_Chip-Seq_ESCs_Mouse1.25346799
59SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25187101
60RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.24695041
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.21895510
62EZH2_27294783_Chip-Seq_ESCs_Mouse1.21618326
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19546680
64REST_21632747_ChIP-Seq_MESCs_Mouse1.19337709
65REST_18959480_ChIP-ChIP_MESCs_Mouse1.19027627
66DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18849106
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17404557
68CREB1_26743006_Chip-Seq_LNCaP_Human1.16781743
69SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15378064
70ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14675242
71* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14359159
72MTF2_20144788_ChIP-Seq_MESCs_Mouse1.14123347
73RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13086189
74CTCF_27219007_Chip-Seq_Bcells_Human1.12849526
75POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.12202149
76NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.11759874
77JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10983014
78SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.10960240
79GATA1_26923725_Chip-Seq_HPCs_Mouse1.10924793
80CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.09447665
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09315699
82EP300_21415370_ChIP-Seq_HL-1_Mouse1.08848633
83DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07707205
84SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.05255948
85CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05116884
86TP53_20018659_ChIP-ChIP_R1E_Mouse1.04350566
87ATF3_27146783_Chip-Seq_COLON_Human1.04311193
88TET1_21490601_ChIP-Seq_MESCs_Mouse1.03634300
89EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03007080
90SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02230309
91RING1B_27294783_Chip-Seq_NPCs_Mouse1.02220411
92TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00645847
93YY1_21170310_ChIP-Seq_MESCs_Mouse1.00268325
94ELK4_26923725_Chip-Seq_MESODERM_Mouse0.99834731
95MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.99773864
96TTF2_22483619_ChIP-Seq_HELA_Human0.99587980
97KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99449176
98TBX20_22328084_ChIP-Seq_HEART_Mouse0.98421447
99TBX20_22080862_ChIP-Seq_HEART_Mouse0.98421447
100RING1B_27294783_Chip-Seq_ESCs_Mouse0.98057777
101EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.96401041
102SALL1_21062744_ChIP-ChIP_HESCs_Human0.96380943
103E2F1_18555785_ChIP-Seq_MESCs_Mouse0.95073025
104IRF1_19129219_ChIP-ChIP_H3396_Human0.94665121
105WDR5_24793694_ChIP-Seq_LNCAP_Human0.94525365
106TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.93867524
107HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.92755466
108TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92543373
109SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.92280836
110NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.92250265
111SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90890279
112* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90590415
113P68_20966046_ChIP-Seq_HELA_Human0.89546284
114DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.89298896
115KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89120233
116PKCTHETA_26484144_Chip-Seq_BREAST_Human0.88965787
117NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.88308749
118POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.88043763
119POU5F1_16518401_ChIP-PET_MESCs_Mouse0.87528801
120ISL1_27105846_Chip-Seq_CPCs_Mouse0.85371141
121PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.85175736
122RUNX1_26923725_Chip-Seq_HPCs_Mouse0.85027901
123UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.83611536
124OCT4_19829295_ChIP-Seq_ESCs_Human0.83108085
125CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82872224
126SMC4_20622854_ChIP-Seq_HELA_Human0.82662189
127* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82254330
128SOX3_22085726_ChIP-Seq_NPCs_Mouse0.81820069
129GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81808648
130KLF4_19829295_ChIP-Seq_ESCs_Human0.81803698
131YY1_22570637_ChIP-Seq_MALME-3M_Human0.81480082
132SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.81466950
133CBX2_27304074_Chip-Seq_ESCs_Mouse0.80866628
134ZFX_18555785_ChIP-Seq_MESCs_Mouse0.80624814
135SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.80356466
136FOXP1_21924763_ChIP-Seq_HESCs_Human0.79709914
137CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.79573957
138OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.79472541
139FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.78998935
140TCF3_18692474_ChIP-Seq_MESCs_Mouse0.78824557
141MYC_18940864_ChIP-ChIP_HL60_Human0.78448149
142PADI4_21655091_ChIP-ChIP_MCF-7_Human0.78059707
143FOXP3_21729870_ChIP-Seq_TREG_Human0.77758585
144BMI1_23680149_ChIP-Seq_NPCS_Mouse0.77417619
145E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.77050099
146EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.76646953
147CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.76511690
148ETS1_20019798_ChIP-Seq_JURKAT_Human0.76197410
149TDRD3_21172665_ChIP-Seq_MCF-7_Human0.76139721
150TET1_21451524_ChIP-Seq_MESCs_Mouse0.75855420
151* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.75713840
152MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.75441367
153RUNX1_27514584_Chip-Seq_MCF-7_Human0.74957012
154TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.74884764
155RNF2_27304074_Chip-Seq_NSC_Mouse0.74390528
156AR_21909140_ChIP-Seq_LNCAP_Human0.74060319
157MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.73951487
158GABP_19822575_ChIP-Seq_HepG2_Human0.73538630
159AR_19668381_ChIP-Seq_PC3_Human0.73356008
160TCF3_18692474_ChIP-Seq_MEFs_Mouse0.71476819
161EED_16625203_ChIP-ChIP_MESCs_Mouse0.69763423
162* XRN2_22483619_ChIP-Seq_HELA_Human0.69602610
163NANOG_16153702_ChIP-ChIP_HESCs_Human0.69303413
164LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.68837712
165TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.67837466
166EST1_17652178_ChIP-ChIP_JURKAT_Human0.67208522
167JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.66861332
168WT1_19549856_ChIP-ChIP_CCG9911_Human0.66198793
169STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.65361014
170PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.64876492
171TBX3_20139965_ChIP-Seq_ESCs_Mouse0.64568644
172POU5F1_16153702_ChIP-ChIP_HESCs_Human0.64474952

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.79153974
2MP0006292_abnormal_olfactory_placode4.12418121
3MP0000751_myopathy3.49108916
4MP0004145_abnormal_muscle_electrophysio3.37277428
5MP0002837_dystrophic_cardiac_calcinosis3.00485815
6MP0002653_abnormal_ependyma_morphology2.58427282
7MP0008057_abnormal_DNA_replication2.58187275
8MP0000566_synostosis2.37850807
9MP0003077_abnormal_cell_cycle2.36701400
10MP0003111_abnormal_nucleus_morphology2.21951881
11MP0010094_abnormal_chromosome_stability2.21906020
12MP0000749_muscle_degeneration2.18492316
13MP0004233_abnormal_muscle_weight2.18211942
14MP0004859_abnormal_synaptic_plasticity2.14869753
15MP0005395_other_phenotype2.14398840
16MP0008932_abnormal_embryonic_tissue2.12713411
17MP0004084_abnormal_cardiac_muscle2.07970069
18MP0004036_abnormal_muscle_relaxation2.05123138
19MP0000750_abnormal_muscle_regeneration2.04701587
20MP0008058_abnormal_DNA_repair2.01012491
21MP0001293_anophthalmia1.97651731
22MP0002106_abnormal_muscle_physiology1.94851499
23MP0004215_abnormal_myocardial_fiber1.93307816
24MP0004270_analgesia1.87103094
25MP0004087_abnormal_muscle_fiber1.84846128
26MP0002269_muscular_atrophy1.84623276
27MP0000747_muscle_weakness1.79947163
28MP0003699_abnormal_female_reproductive1.78358841
29MP0003941_abnormal_skin_development1.75313631
30MP0003123_paternal_imprinting1.71139151
31MP0005620_abnormal_muscle_contractility1.68316461
32MP0000759_abnormal_skeletal_muscle1.66956739
33MP0002234_abnormal_pharynx_morphology1.62501129
34MP0002233_abnormal_nose_morphology1.60771091
35MP0005330_cardiomyopathy1.59807015
36MP0004130_abnormal_muscle_cell1.56844744
37MP0009379_abnormal_foot_pigmentation1.56746316
38MP0002139_abnormal_hepatobiliary_system1.55636129
39MP0003137_abnormal_impulse_conducting1.53675615
40MP0005369_muscle_phenotype1.52576626
41MP0010030_abnormal_orbit_morphology1.51294073
42MP0003718_maternal_effect1.44091194
43MP0004185_abnormal_adipocyte_glucose1.43362509
44MP0002160_abnormal_reproductive_system1.42872865
45MP0004043_abnormal_pH_regulation1.41068709
46MP0003879_abnormal_hair_cell1.39491872
47MP0004484_altered_response_of1.36649727
48MP0002161_abnormal_fertility/fecundity1.35706103
49MP0000537_abnormal_urethra_morphology1.35598891
50MP0005380_embryogenesis_phenotype1.34671296
51MP0001145_abnormal_male_reproductive1.27808603
52MP0010307_abnormal_tumor_latency1.26483761
53MP0003705_abnormal_hypodermis_morpholog1.24855825
54MP0000350_abnormal_cell_proliferation1.24784131
55MP0002697_abnormal_eye_size1.23704771
56MP0002972_abnormal_cardiac_muscle1.23493685
57MP0003119_abnormal_digestive_system1.22392723
58MP0003635_abnormal_synaptic_transmissio1.19187055
59MP0000631_abnormal_neuroendocrine_gland1.17777541
60MP0003221_abnormal_cardiomyocyte_apopto1.17194671
61MP0000428_abnormal_craniofacial_morphol1.15615087
62MP0000733_abnormal_muscle_development1.15222935
63MP0003283_abnormal_digestive_organ1.13720070
64MP0003693_abnormal_embryo_hatching1.10139154
65MP0000678_abnormal_parathyroid_gland1.05691011
66MP0003136_yellow_coat_color1.04834930
67MP0001286_abnormal_eye_development1.04791432
68MP0005076_abnormal_cell_differentiation1.04026667
69MP0002877_abnormal_melanocyte_morpholog1.03881479
70MP0006036_abnormal_mitochondrial_physio1.03869584
71MP0003122_maternal_imprinting1.03620686
72MP0010368_abnormal_lymphatic_system1.02870195
73MP0002909_abnormal_adrenal_gland1.02846685
74MP0003950_abnormal_plasma_membrane1.02834355
75MP0005410_abnormal_fertilization1.01998808
76MP0002089_abnormal_postnatal_growth/wei1.01625691
77MP0005360_urolithiasis1.01251510
78MP0004957_abnormal_blastocyst_morpholog1.00681882
79MP0002249_abnormal_larynx_morphology1.00284338
80MP0003937_abnormal_limbs/digits/tail_de1.00254112
81MP0001849_ear_inflammation0.99925137
82MP0008877_abnormal_DNA_methylation0.99579012
83MP0005499_abnormal_olfactory_system0.99348393
84MP0005394_taste/olfaction_phenotype0.99348393
85MP0002092_abnormal_eye_morphology0.99317162
86MP0008789_abnormal_olfactory_epithelium0.99207506
87MP0002332_abnormal_exercise_endurance0.98962012
88MP0004085_abnormal_heartbeat0.98687646
89MP0003698_abnormal_male_reproductive0.98548994
90MP0002796_impaired_skin_barrier0.97954166
91MP0003935_abnormal_craniofacial_develop0.97717628
92MP0002063_abnormal_learning/memory/cond0.97139977
93MP0003121_genomic_imprinting0.96896052
94MP0001119_abnormal_female_reproductive0.96229569
95MP0005187_abnormal_penis_morphology0.96117155
96MP0003890_abnormal_embryonic-extraembry0.96056604
97MP0009250_abnormal_appendicular_skeleto0.95741000
98MP0005666_abnormal_adipose_tissue0.95274544
99MP0003880_abnormal_central_pattern0.95030720
100MP0000778_abnormal_nervous_system0.93553266
101MP0002084_abnormal_developmental_patter0.93534513
102MP0003315_abnormal_perineum_morphology0.93203820
103MP0005501_abnormal_skin_physiology0.92091246
104MP0002184_abnormal_innervation0.91770339
105MP0010630_abnormal_cardiac_muscle0.91402004
106MP0005451_abnormal_body_composition0.90968749
107MP0010234_abnormal_vibrissa_follicle0.89001149
108MP0003984_embryonic_growth_retardation0.88714024
109MP0001529_abnormal_vocalization0.87626644
110MP0005385_cardiovascular_system_phenoty0.87495072
111MP0001544_abnormal_cardiovascular_syste0.87495072
112MP0005646_abnormal_pituitary_gland0.87041028
113MP0006138_congestive_heart_failure0.86703046
114MP0006035_abnormal_mitochondrial_morpho0.86532459
115MP0001346_abnormal_lacrimal_gland0.86501542
116MP0001730_embryonic_growth_arrest0.86142040
117MP0002734_abnormal_mechanical_nocicepti0.85836602
118MP0003861_abnormal_nervous_system0.85182029
119MP0002088_abnormal_embryonic_growth/wei0.84824542
120MP0002085_abnormal_embryonic_tissue0.84681653
121MP0002210_abnormal_sex_determination0.83801710
122MP0001929_abnormal_gametogenesis0.83795530
123MP0003385_abnormal_body_wall0.82566357
124MP0006276_abnormal_autonomic_nervous0.82285434
125MP0002116_abnormal_craniofacial_bone0.81846249
126MP0004858_abnormal_nervous_system0.81687247
127MP0000534_abnormal_ureter_morphology0.81308552
128MP0006072_abnormal_retinal_apoptosis0.80009581
129MP0003755_abnormal_palate_morphology0.79984650
130MP0001299_abnormal_eye_distance/0.79598632
131MP0000049_abnormal_middle_ear0.79594546
132MP0003567_abnormal_fetal_cardiomyocyte0.79294487
133MP0009672_abnormal_birth_weight0.79183510
134MP0002127_abnormal_cardiovascular_syste0.78715767
135MP0002080_prenatal_lethality0.77978009
136MP0003942_abnormal_urinary_system0.77948909
137MP0005389_reproductive_system_phenotype0.76337939
138MP0005623_abnormal_meninges_morphology0.75410747
139MP0000955_abnormal_spinal_cord0.75073349
140MP0003787_abnormal_imprinting0.74959160
141MP0002102_abnormal_ear_morphology0.74896221
142MP0003183_abnormal_peptide_metabolism0.74163452
143MP0002138_abnormal_hepatobiliary_system0.73890522
144MP0002114_abnormal_axial_skeleton0.72592624
145MP0005248_abnormal_Harderian_gland0.72557356
146MP0000762_abnormal_tongue_morphology0.72421412
147MP0002111_abnormal_tail_morphology0.72187952
148MP0005386_behavior/neurological_phenoty0.71262579
149MP0004924_abnormal_behavior0.71262579
150MP0001697_abnormal_embryo_size0.70463097
151MP0004197_abnormal_fetal_growth/weight/0.70395689
152MP0000653_abnormal_sex_gland0.70132468
153MP0001672_abnormal_embryogenesis/_devel0.69922701
154MP0005647_abnormal_sex_gland0.66746921
155MP0002163_abnormal_gland_morphology0.66031172
156MP0005197_abnormal_uvea_morphology0.64721945
157MP0005508_abnormal_skeleton_morphology0.62647749
158MP0010678_abnormal_skin_adnexa0.59991928
159MP0002177_abnormal_outer_ear0.56491129
160MP0000427_abnormal_hair_cycle0.55110285
161MP0001340_abnormal_eyelid_morphology0.54304159

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)4.71028607
2Supernumerary spleens (HP:0009799)4.40608420
3Septo-optic dysplasia (HP:0100842)4.29247511
4Osteomalacia (HP:0002749)4.21229485
5Facial hemangioma (HP:0000329)4.10019099
6Abdominal situs inversus (HP:0003363)4.09503536
7Abnormality of abdominal situs (HP:0011620)4.09503536
8Muscle fiber inclusion bodies (HP:0100299)4.07378303
9Muscle fiber splitting (HP:0003555)4.04905882
10Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.93753779
11Muscle hypertrophy of the lower extremities (HP:0008968)3.87401137
12Exercise-induced muscle cramps (HP:0003710)3.86027308
13Calf muscle hypertrophy (HP:0008981)3.81484969
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.68456687
15Chromsome breakage (HP:0040012)3.67759715
16Sudden death (HP:0001699)3.63595790
17Nemaline bodies (HP:0003798)3.53192808
18Impulsivity (HP:0100710)3.51958864
19Absent septum pellucidum (HP:0001331)3.43081590
20Type 1 muscle fiber predominance (HP:0003803)3.28814860
21Lip pit (HP:0100267)3.20276962
22Bundle branch block (HP:0011710)3.19771531
23Abnormality of the calf musculature (HP:0001430)3.16076492
24Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.15497541
25Abnormality of the phalanges of the hallux (HP:0010057)3.13058103
26Oligodactyly (hands) (HP:0001180)3.12869160
27Difficulty climbing stairs (HP:0003551)3.11786026
28Difficulty running (HP:0009046)3.10520361
29Hypophosphatemic rickets (HP:0004912)3.07053702
30Male infertility (HP:0003251)3.00298911
31Hyporeflexia of lower limbs (HP:0002600)3.00176652
32Myoglobinuria (HP:0002913)2.99318484
33Anterior segment dysgenesis (HP:0007700)2.97955953
34Abnormality of the septum pellucidum (HP:0007375)2.94893227
35Cholecystitis (HP:0001082)2.92294178
36Abnormal gallbladder physiology (HP:0012438)2.92294178
37Capillary hemangiomas (HP:0005306)2.90692317
38Median cleft lip (HP:0000161)2.87983938
39Maternal diabetes (HP:0009800)2.86360397
40Myopathic facies (HP:0002058)2.84213025
41Ventricular fibrillation (HP:0001663)2.74102538
42Oligodactyly (HP:0012165)2.72961369
43Enlarged penis (HP:0000040)2.71390306
44Gonadotropin excess (HP:0000837)2.69060035
45Nephroblastoma (Wilms tumor) (HP:0002667)2.66809233
46Myotonia (HP:0002486)2.63938019
47Distal arthrogryposis (HP:0005684)2.58926125
48Microglossia (HP:0000171)2.58611547
49Abnormality of the left ventricular outflow tract (HP:0011103)2.58410829
50Subaortic stenosis (HP:0001682)2.58410829
51Abnormal lung lobation (HP:0002101)2.56803854
52Premature ovarian failure (HP:0008209)2.54906153
53Spinal cord compression (HP:0002176)2.50633995
54Embryonal renal neoplasm (HP:0011794)2.48900121
55EMG: myopathic abnormalities (HP:0003458)2.48066084
56Skin pits (HP:0100276)2.41291044
57Calcaneovalgus deformity (HP:0001848)2.39856852
58Shallow orbits (HP:0000586)2.38897686
59Fetal akinesia sequence (HP:0001989)2.38340785
60Azoospermia (HP:0000027)2.38181183
61Ankle contracture (HP:0006466)2.36615343
62Shoulder girdle muscle weakness (HP:0003547)2.29348896
63Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.29306362
64Primary atrial arrhythmia (HP:0001692)2.27365510
65Partial duplication of thumb phalanx (HP:0009944)2.27100154
66Urethral obstruction (HP:0000796)2.26231972
67Increased nuchal translucency (HP:0010880)2.26168007
68Ventricular tachycardia (HP:0004756)2.26132476
69Hypoplasia of the fovea (HP:0007750)2.25629413
70Aplasia/Hypoplasia of the fovea (HP:0008060)2.25629413
71Focal motor seizures (HP:0011153)2.23961930
72Short tibia (HP:0005736)2.22693922
73Deformed tarsal bones (HP:0008119)2.21142254
74Atrial fibrillation (HP:0005110)2.19913713
75EMG: neuropathic changes (HP:0003445)2.18332952
76Hypokinesia (HP:0002375)2.17876765
77Partial duplication of the phalanx of hand (HP:0009999)2.17773030
78Round ear (HP:0100830)2.17557687
79Gout (HP:0001997)2.17412509
80Supraventricular tachycardia (HP:0004755)2.16556563
81Areflexia of lower limbs (HP:0002522)2.15369014
82Duplication of thumb phalanx (HP:0009942)2.14024652
83Ulnar deviation of the wrist (HP:0003049)2.13692020
84Supraventricular arrhythmia (HP:0005115)2.13129393
85Heart block (HP:0012722)2.13077707
86Heterotopia (HP:0002282)2.12361112
87Increased variability in muscle fiber diameter (HP:0003557)2.11268828
88Asymmetric septal hypertrophy (HP:0001670)2.10470065
89Bifid tongue (HP:0010297)2.10234888
90Absent radius (HP:0003974)2.08710184
91Increased connective tissue (HP:0009025)2.07234183
92Bicornuate uterus (HP:0000813)2.05757060
93Muscle stiffness (HP:0003552)2.05751680
94Rhabdomyolysis (HP:0003201)2.02965033
95Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.02373362
96Hypoplastic ischia (HP:0003175)2.02147473
97Abnormal atrioventricular conduction (HP:0005150)2.01403828
98Periauricular skin pits (HP:0100277)1.98766115
99Preauricular pit (HP:0004467)1.98766115
100Pelvic girdle muscle weakness (HP:0003749)1.98660340
101Aplasia of the musculature (HP:0100854)1.98172019
102Facial cleft (HP:0002006)1.97462388
103Wrist flexion contracture (HP:0001239)1.96657243
104Atrioventricular block (HP:0001678)1.96123261
105Abnormality of skeletal muscle fiber size (HP:0012084)1.95755207
106Aplasia involving forearm bones (HP:0009822)1.95197365
107Absent forearm bone (HP:0003953)1.95197365
108Apathy (HP:0000741)1.94921201
109Myokymia (HP:0002411)1.94560837
110Papillary thyroid carcinoma (HP:0002895)1.93884753
111Diminished motivation (HP:0000745)1.93710737
112Meckel diverticulum (HP:0002245)1.93365701
113Abnormality of the fovea (HP:0000493)1.91359442
114Proximal tubulopathy (HP:0000114)1.90308034
115Hydroureter (HP:0000072)1.88164751
116Ventricular arrhythmia (HP:0004308)1.87705448
117Absent phalangeal crease (HP:0006109)1.82824487
118Proximal amyotrophy (HP:0007126)1.81664752
119Sensory axonal neuropathy (HP:0003390)1.80219038
120Abnormality of the musculature of the pelvis (HP:0001469)1.80104173
121Abnormality of the hip-girdle musculature (HP:0001445)1.80104173
122Abnormality of the ileum (HP:0001549)1.79463956
123Abnormality of alanine metabolism (HP:0010916)1.79390447
124Hyperalaninemia (HP:0003348)1.79390447
125Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79390447
126Neck muscle weakness (HP:0000467)1.79328251
127Failure to thrive in infancy (HP:0001531)1.78302848
128Stillbirth (HP:0003826)1.77835488
129Truncal obesity (HP:0001956)1.77700845
130Abnormality of chromosome segregation (HP:0002916)1.77239536
131Multiple enchondromatosis (HP:0005701)1.76685365
132Achilles tendon contracture (HP:0001771)1.76369138
133Thyroid carcinoma (HP:0002890)1.76297551
134Rectal prolapse (HP:0002035)1.75582635
135Horseshoe kidney (HP:0000085)1.74820643
136Syncope (HP:0001279)1.74153348
137Acute encephalopathy (HP:0006846)1.73679087
138Reticulocytopenia (HP:0001896)1.73430435
139Acute necrotizing encephalopathy (HP:0006965)1.73237355
140Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.73077508
141Aplasia/Hypoplasia of the uvula (HP:0010293)1.72900633
142Optic nerve hypoplasia (HP:0000609)1.72788845
143Abnormal mitochondria in muscle tissue (HP:0008316)1.72543502
144Increased purine levels (HP:0004368)1.72524372
145Hyperuricemia (HP:0002149)1.72524372
146Aplasia/Hypoplasia of the tibia (HP:0005772)1.71863199
147Triphalangeal thumb (HP:0001199)1.68464287
148Short thumb (HP:0009778)1.68022237
149Prolonged QT interval (HP:0001657)1.67758518
150Hip contracture (HP:0003273)1.67567888
151Abnormal spermatogenesis (HP:0008669)1.67431292
152Hamartoma of the eye (HP:0010568)1.67425255
153Limb-girdle muscle weakness (HP:0003325)1.67210402
154Abnormality of chromosome stability (HP:0003220)1.66965208
155Broad alveolar ridges (HP:0000187)1.66954184
156Infertility (HP:0000789)1.66643714
157Shawl scrotum (HP:0000049)1.66577891
158Gowers sign (HP:0003391)1.65910576
159Ectopic kidney (HP:0000086)1.65528265
160Embryonal neoplasm (HP:0002898)1.65183277
161Rimmed vacuoles (HP:0003805)1.63604532
162Ketoacidosis (HP:0001993)1.63536546
163Abnormal EKG (HP:0003115)1.63303345
164Abnormality of the Achilles tendon (HP:0005109)1.62831449
165Atresia of the external auditory canal (HP:0000413)1.62770522
166Intrahepatic cholestasis (HP:0001406)1.62707016
167Small intestinal stenosis (HP:0012848)1.61943351
168Duodenal stenosis (HP:0100867)1.61943351
169Abnormality of the ischium (HP:0003174)1.60036525
170Mildly elevated creatine phosphokinase (HP:0008180)1.58641351
171Birth length less than 3rd percentile (HP:0003561)1.58427322
172Conjunctival hamartoma (HP:0100780)1.58000239
173Aplasia/Hypoplasia of the macula (HP:0008059)1.57932324
174Midline defect of the nose (HP:0004122)1.57866516
175Abnormality of the shoulder girdle musculature (HP:0001435)1.57190943
176Myelomeningocele (HP:0002475)1.57004100
177Visual hallucinations (HP:0002367)1.56889205
178Abnormality of the anterior chamber (HP:0000593)1.56573331
179Uterine leiomyosarcoma (HP:0002891)1.56341383
180Leiomyosarcoma (HP:0100243)1.56341383
181Progressive muscle weakness (HP:0003323)1.56296086
182Progressive macrocephaly (HP:0004481)1.56124047
183Adenoma sebaceum (HP:0009720)1.55212276
184Angiofibromas (HP:0010615)1.55212276
185Abnormality of the labia minora (HP:0012880)1.54847543
186Truncus arteriosus (HP:0001660)1.54318461
187Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.54119553
188Left ventricular hypertrophy (HP:0001712)1.53839551
189Lipoatrophy (HP:0100578)1.53755537
190Amblyopia (HP:0000646)1.53044059
191Abnormal finger flexion creases (HP:0006143)1.52647421
192Right ventricular cardiomyopathy (HP:0011663)1.52279074
193Congenital malformation of the right heart (HP:0011723)1.52117164

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K133.76581459
2LATS23.50189518
3MAP3K92.91741539
4STK38L2.82388939
5PRKD32.77563521
6LATS12.67909214
7NEK12.41973668
8KSR22.40102898
9PHKG22.33306859
10PHKG12.33306859
11TRIB32.32684285
12PDK42.28569342
13PDK32.28569342
14MOS2.26060951
15KSR12.18585895
16TTN2.13658147
17PINK12.12446441
18NEK62.09160033
19MAP3K42.07665598
20OBSCN2.00755984
21MET1.98648754
22MAP3K61.82980754
23TAOK11.78282678
24CDK71.72186981
25CDK91.69312431
26MAP2K41.66874956
27BRSK11.64300149
28PAK61.64026314
29STK381.63018275
30EIF2AK31.55932237
31BMPR21.49751591
32TYRO31.49407210
33BRSK21.39802322
34NME11.37380815
35PBK1.37249985
36DMPK1.34122996
37WNK41.31422611
38DYRK21.29821243
39PRKCI1.27588552
40PTK21.27029338
41SRPK11.26886848
42EPHA41.25917579
43CDK191.24700824
44MARK11.21817805
45PKN21.21085453
46MAP2K71.20500140
47PLK31.19140441
48MELK1.16833957
49PDK21.16323828
50LMTK21.08945291
51TNIK1.08748156
52WNK31.08043574
53VRK21.07156760
54TTK1.01663083
55CHEK11.00904113
56AURKB1.00120303
57MAP3K80.99601593
58ZAK0.96126857
59NTRK30.94970494
60BCKDK0.94393722
61ICK0.93114756
62MUSK0.92011788
63BRAF0.90936177
64MINK10.89778988
65PRKAA10.89243730
66ARAF0.88054050
67EPHB20.84355594
68MAPKAPK30.83260673
69TRIM280.82634489
70NEK20.82093943
71MTOR0.80971391
72MAPK130.80125219
73CDK20.79000001
74RET0.78704886
75CSNK1G30.78103082
76ATR0.74692301
77PDGFRA0.74264978
78WEE10.73488572
79DDR20.70525271
80ATM0.69783121
81SMG10.67868941
82PAK30.66184379
83NTRK10.65944486
84VRK10.65763229
85RPS6KB20.64976726
86RAF10.64920982
87CDK10.64619045
88MAP3K30.62843637
89MAP3K20.62756448
90ILK0.62223018
91CDK80.62209337
92NEK90.60810934
93NME20.60420978
94CDC70.60162038
95EEF2K0.60005373
96PNCK0.57448590
97UHMK10.56022587
98CSNK1A1L0.55847833
99ERBB40.55653511
100PLK40.54504008
101NTRK20.53673153
102STK30.52763944
103SGK2230.52615342
104SGK4940.52615342
105MAP3K110.52610030
106PAK10.52519296
107DYRK30.51570606
108CHEK20.51278647
109ABL20.51123551
110BRD40.50617710
111OXSR10.48384623
112PRKD20.48384131
113CAMK2A0.48275253
114PIM10.46059948
115CAMK1G0.45653803
116TSSK60.44422522
117ROCK10.44307185
118FER0.44003991
119BUB10.43956586
120PLK10.43631744
121STK110.43148247
122STK160.43144791
123CDK50.41631788
124MAP2K10.41434252
125CDK120.41058474
126CSNK1G20.40781911
127STK390.40710020
128AURKA0.40557014
129CSNK1D0.39730788
130LRRK20.38948576
131CDK180.38416217
132STK240.38400177
133CSNK1E0.37403156
134CDK150.37347550
135MAP3K100.37069698
136CAMKK10.37040622
137MAP3K50.35822591
138ERBB30.35781875
139AKT20.34985391
140EIF2AK20.34251038
141CSNK1G10.33253426
142WNK10.33148035
143SGK20.33047815
144CDK11A0.32430623
145SGK30.32135883
146TGFBR10.32017998
147NUAK10.31435665
148TIE10.31393471
149CDK140.30812410
150TAF10.29926499
151GSK3B0.28874406
152EIF2AK10.28434534
153CSNK2A20.28429068

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.87240748
2DNA replication_Homo sapiens_hsa030303.40333490
3Base excision repair_Homo sapiens_hsa034103.07736733
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.94159265
5Nucleotide excision repair_Homo sapiens_hsa034202.51079465
6Cardiac muscle contraction_Homo sapiens_hsa042602.38651482
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.30305144
8Homologous recombination_Homo sapiens_hsa034402.01746794
9Fanconi anemia pathway_Homo sapiens_hsa034601.93109410
10Oocyte meiosis_Homo sapiens_hsa041141.85090302
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.84933415
12Ribosome_Homo sapiens_hsa030101.83151950
13Parkinsons disease_Homo sapiens_hsa050121.69583047
14Propanoate metabolism_Homo sapiens_hsa006401.65655591
15Dilated cardiomyopathy_Homo sapiens_hsa054141.64744474
16Folate biosynthesis_Homo sapiens_hsa007901.63561624
17p53 signaling pathway_Homo sapiens_hsa041151.59128841
18Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.55864227
19Spliceosome_Homo sapiens_hsa030401.54177428
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.53570650
21Oxidative phosphorylation_Homo sapiens_hsa001901.51210469
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49316304
23Huntingtons disease_Homo sapiens_hsa050161.46949901
24Long-term potentiation_Homo sapiens_hsa047201.45424667
25Circadian rhythm_Homo sapiens_hsa047101.42638090
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.42226415
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.42107505
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.41238303
29mTOR signaling pathway_Homo sapiens_hsa041501.40400352
30RNA polymerase_Homo sapiens_hsa030201.40144479
31GnRH signaling pathway_Homo sapiens_hsa049121.33595006
32Insulin signaling pathway_Homo sapiens_hsa049101.27864826
33Thyroid cancer_Homo sapiens_hsa052161.27364469
34Hippo signaling pathway_Homo sapiens_hsa043901.24096855
35Pyruvate metabolism_Homo sapiens_hsa006201.23824896
36Carbon metabolism_Homo sapiens_hsa012001.22560098
37Oxytocin signaling pathway_Homo sapiens_hsa049211.22462915
38Glucagon signaling pathway_Homo sapiens_hsa049221.22458458
39Adherens junction_Homo sapiens_hsa045201.21693942
40Synaptic vesicle cycle_Homo sapiens_hsa047211.21309599
41Alzheimers disease_Homo sapiens_hsa050101.19242897
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17267802
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16664241
44Butanoate metabolism_Homo sapiens_hsa006501.14653312
45Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.12202171
46Glioma_Homo sapiens_hsa052141.11082330
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.10988273
48Tight junction_Homo sapiens_hsa045301.10745526
49Gap junction_Homo sapiens_hsa045401.10710844
50Longevity regulating pathway - mammal_Homo sapiens_hsa042111.09168076
51Endometrial cancer_Homo sapiens_hsa052131.08853038
52Non-homologous end-joining_Homo sapiens_hsa034501.06579666
53Dopaminergic synapse_Homo sapiens_hsa047281.06149919
54Dorso-ventral axis formation_Homo sapiens_hsa043201.05466535
55Ovarian steroidogenesis_Homo sapiens_hsa049131.05329243
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04213709
57Fatty acid elongation_Homo sapiens_hsa000621.02535245
58Hedgehog signaling pathway_Homo sapiens_hsa043401.02121110
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01676665
60Biosynthesis of amino acids_Homo sapiens_hsa012301.01033000
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00498675
62Olfactory transduction_Homo sapiens_hsa047400.98715751
63Notch signaling pathway_Homo sapiens_hsa043300.97413551
64VEGF signaling pathway_Homo sapiens_hsa043700.97376609
65Amphetamine addiction_Homo sapiens_hsa050310.96900828
66AMPK signaling pathway_Homo sapiens_hsa041520.94913183
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94708544
68mRNA surveillance pathway_Homo sapiens_hsa030150.94608694
69Insulin secretion_Homo sapiens_hsa049110.93129613
70Melanogenesis_Homo sapiens_hsa049160.92622343
71MicroRNAs in cancer_Homo sapiens_hsa052060.92557139
72Vitamin B6 metabolism_Homo sapiens_hsa007500.91591057
73Renal cell carcinoma_Homo sapiens_hsa052110.91359729
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91096363
75Long-term depression_Homo sapiens_hsa047300.90362881
76ErbB signaling pathway_Homo sapiens_hsa040120.89742748
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88641093
78Gastric acid secretion_Homo sapiens_hsa049710.87752622
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87659961
80Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87368477
81Nicotine addiction_Homo sapiens_hsa050330.87097849
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86778306
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85963714
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84977462
85Pyrimidine metabolism_Homo sapiens_hsa002400.84770982
86Estrogen signaling pathway_Homo sapiens_hsa049150.83435001
87Caffeine metabolism_Homo sapiens_hsa002320.82433017
88Basal cell carcinoma_Homo sapiens_hsa052170.81051156
89Glutamatergic synapse_Homo sapiens_hsa047240.80904434
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80195055
91Bladder cancer_Homo sapiens_hsa052190.79887783
92Wnt signaling pathway_Homo sapiens_hsa043100.79394661
93Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78663027
94Basal transcription factors_Homo sapiens_hsa030220.77196001
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.76600115
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76049382
97Circadian entrainment_Homo sapiens_hsa047130.75953680
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.75460549
99Cholinergic synapse_Homo sapiens_hsa047250.74123983
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73428391
101Colorectal cancer_Homo sapiens_hsa052100.73158536
102Cell cycle_Homo sapiens_hsa041100.72785865
103Purine metabolism_Homo sapiens_hsa002300.72304348
104Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71244059
105Non-small cell lung cancer_Homo sapiens_hsa052230.70984570
106GABAergic synapse_Homo sapiens_hsa047270.70891690
107RNA transport_Homo sapiens_hsa030130.70148879
108Choline metabolism in cancer_Homo sapiens_hsa052310.68563218
109RNA degradation_Homo sapiens_hsa030180.68030637
110Sulfur relay system_Homo sapiens_hsa041220.65020544
111Insulin resistance_Homo sapiens_hsa049310.63347371
112Calcium signaling pathway_Homo sapiens_hsa040200.62479345
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.61968445
114TGF-beta signaling pathway_Homo sapiens_hsa043500.60999790
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60949635
116Fatty acid degradation_Homo sapiens_hsa000710.60621681
117Arginine biosynthesis_Homo sapiens_hsa002200.60372296
118Axon guidance_Homo sapiens_hsa043600.59351200
119Steroid biosynthesis_Homo sapiens_hsa001000.58426120
120Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57442415
121Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56649132
122Small cell lung cancer_Homo sapiens_hsa052220.56164847
123Prolactin signaling pathway_Homo sapiens_hsa049170.56032393
124Arginine and proline metabolism_Homo sapiens_hsa003300.55731208
125Renin secretion_Homo sapiens_hsa049240.55501159
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55144178
127cAMP signaling pathway_Homo sapiens_hsa040240.55089395
128Melanoma_Homo sapiens_hsa052180.54980746
129Inositol phosphate metabolism_Homo sapiens_hsa005620.48124862
130Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45919979
131Viral carcinogenesis_Homo sapiens_hsa052030.45501870
132FoxO signaling pathway_Homo sapiens_hsa040680.43811024
133Lysine degradation_Homo sapiens_hsa003100.42659535
134Selenocompound metabolism_Homo sapiens_hsa004500.40873049
135HTLV-I infection_Homo sapiens_hsa051660.39030374
136Prostate cancer_Homo sapiens_hsa052150.38503879
137Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37348479
138Pathways in cancer_Homo sapiens_hsa052000.37001224
139Proteoglycans in cancer_Homo sapiens_hsa052050.35823173
140Pentose phosphate pathway_Homo sapiens_hsa000300.35754614
141Proteasome_Homo sapiens_hsa030500.31320218
142Prion diseases_Homo sapiens_hsa050200.31300097
143Phototransduction_Homo sapiens_hsa047440.29645378
144One carbon pool by folate_Homo sapiens_hsa006700.25701310
145PI3K-Akt signaling pathway_Homo sapiens_hsa041510.25500828
146Bile secretion_Homo sapiens_hsa049760.25080386
147Protein digestion and absorption_Homo sapiens_hsa049740.24515333

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