BOD1L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K4 trimethylation (GO:0080182)4.84183444
2detection of molecule of bacterial origin (GO:0032490)4.52365978
3positive regulation of gamma-delta T cell activation (GO:0046645)4.49084063
4establishment of protein localization to Golgi (GO:0072600)4.37240677
5regulation of B cell receptor signaling pathway (GO:0050855)4.27327778
6peptidyl-lysine trimethylation (GO:0018023)4.22034548
7phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.14721110
8protein targeting to Golgi (GO:0000042)4.11823134
9positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.10519589
10monoubiquitinated protein deubiquitination (GO:0035520)4.08629073
11retrograde transport, vesicle recycling within Golgi (GO:0000301)4.01801902
12negative regulation of translation, ncRNA-mediated (GO:0040033)3.99494533
13regulation of translation, ncRNA-mediated (GO:0045974)3.99494533
14negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.99494533
15microglial cell activation (GO:0001774)3.92077698
16negative regulation of cell killing (GO:0031342)3.84702210
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.84702210
18modulation by symbiont of host defense response (GO:0052031)3.81675774
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.81675774
20modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.81675774
21positive regulation by organism of defense response of other organism involved in symbiotic interact3.81675774
22modulation by symbiont of host immune response (GO:0052553)3.81675774
23positive regulation by symbiont of host defense response (GO:0052509)3.81675774
24activated T cell proliferation (GO:0050798)3.56272032
25cellular extravasation (GO:0045123)3.56027153
26histone H3-K9 modification (GO:0061647)3.52868590
27histone H3-K9 methylation (GO:0051567)3.47631033
28neutrophil mediated immunity (GO:0002446)3.45008993
29neural tube formation (GO:0001841)3.39393571
30regulation of gamma-delta T cell activation (GO:0046643)3.38142242
31pre-miRNA processing (GO:0031054)3.38014684
32interkinetic nuclear migration (GO:0022027)3.37128476
33negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.36939087
34regulation of gamma-delta T cell differentiation (GO:0045586)3.35549013
35macrophage activation involved in immune response (GO:0002281)3.33000353
36peptidyl-lysine methylation (GO:0018022)3.30889714
37negative regulation of T cell mediated immunity (GO:0002710)3.29120096
38macrophage activation (GO:0042116)3.24998963
39cytoplasmic mRNA processing body assembly (GO:0033962)3.17676676
40myeloid leukocyte mediated immunity (GO:0002444)3.14909433
41positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.09323114
42B cell receptor signaling pathway (GO:0050853)3.08838726
43response to interleukin-15 (GO:0070672)3.08592448
44histone mRNA catabolic process (GO:0071044)3.07317752
45negative regulation of B cell proliferation (GO:0030889)3.04126617
46regulation of interferon-beta biosynthetic process (GO:0045357)3.03608737
47histone H3-K36 demethylation (GO:0070544)3.01676079
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.99907498
49negative regulation of lymphocyte mediated immunity (GO:0002707)2.99718030
50detection of external biotic stimulus (GO:0098581)2.96557195
51positive T cell selection (GO:0043368)2.92742497
52regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.91118292
53negative regulation of cAMP-mediated signaling (GO:0043951)2.90008565
54cellular response to ethanol (GO:0071361)2.87575544
55protein K11-linked deubiquitination (GO:0035871)2.86211777
56positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.85759895
57centrosome localization (GO:0051642)2.80710965
58histone H3-K4 methylation (GO:0051568)2.78602084
59negative T cell selection (GO:0043383)2.78183881
60response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.78165658
61response to host immune response (GO:0052572)2.78165658
62cellular response to interleukin-15 (GO:0071350)2.78076842
63hepatocyte apoptotic process (GO:0097284)2.77651843
64negative thymic T cell selection (GO:0045060)2.74648238
65regulation of RNA export from nucleus (GO:0046831)2.74215434
66negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.72878385
67regulation of establishment of cell polarity (GO:2000114)2.69816507
68positive regulation of granulocyte differentiation (GO:0030854)2.69186179
69regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.68266286
70negative regulation of B cell mediated immunity (GO:0002713)2.65131563
71negative regulation of immunoglobulin mediated immune response (GO:0002890)2.65131563
72protein targeting to lysosome (GO:0006622)2.64232743
73establishment of protein localization to vacuole (GO:0072666)2.64232743
74protein targeting to vacuole (GO:0006623)2.64232743
75histone lysine methylation (GO:0034968)2.62371559
76interferon-gamma production (GO:0032609)2.61961370
77response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.61897920
78response to host (GO:0075136)2.61897920
79response to host defenses (GO:0052200)2.61897920
80protein localization to Golgi apparatus (GO:0034067)2.60052943
81detection of biotic stimulus (GO:0009595)2.56358178
82positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.56183213
83cerebellar Purkinje cell differentiation (GO:0021702)2.54952521
84regulation of beta-amyloid formation (GO:1902003)2.52153629
85nerve growth factor signaling pathway (GO:0038180)2.51508715
86protein K48-linked deubiquitination (GO:0071108)2.51145816
87nucleus localization (GO:0051647)2.50821213
88histone H3-K9 demethylation (GO:0033169)2.49370462
89regulation of MHC class I biosynthetic process (GO:0045343)2.48110839
90detection of other organism (GO:0098543)2.46469608
91negative regulation of adaptive immune response (GO:0002820)2.46254404
92dosage compensation (GO:0007549)2.44493240
93production of molecular mediator involved in inflammatory response (GO:0002532)2.41385762
94negative regulation of neurotransmitter transport (GO:0051589)2.39574519
95establishment of nucleus localization (GO:0040023)2.39386804
96negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.38413207
97negative regulation of neurotransmitter secretion (GO:0046929)2.37106177
98peptidyl-threonine phosphorylation (GO:0018107)2.37061604
99microtubule anchoring (GO:0034453)2.36065982
100positive thymic T cell selection (GO:0045059)2.35945183

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.48880557
2CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.95561868
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.90907749
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.87040482
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.71249971
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.49405605
7SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.13638781
8GBX2_23144817_ChIP-Seq_PC3_Human2.04926378
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.04523147
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.96197193
11RUNX_20019798_ChIP-Seq_JUKART_Human1.94385187
12POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93666830
13TP53_16413492_ChIP-PET_HCT116_Human1.92435705
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.90384307
15IRF8_22096565_ChIP-ChIP_GC-B_Human1.90105534
16RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86241683
17AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.78188065
18TAF15_26573619_Chip-Seq_HEK293_Human1.77301288
19PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73077600
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.72043294
21POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.70613894
22TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70613894
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.65369914
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.63225676
25IRF8_27001747_Chip-Seq_BMDM_Mouse1.61134694
26IRF8_21731497_ChIP-ChIP_J774_Mouse1.60720302
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.52772872
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.50806471
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50719543
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49579330
31STAT3_23295773_ChIP-Seq_U87_Human1.47823733
32MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47273282
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46782708
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45456590
35AHR_22903824_ChIP-Seq_MCF-7_Human1.45184575
36EZH2_22144423_ChIP-Seq_EOC_Human1.44439699
37Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.43475790
38SCL_19346495_ChIP-Seq_HPC-7_Human1.43216682
39SMAD4_21799915_ChIP-Seq_A2780_Human1.42096495
40ARNT_22903824_ChIP-Seq_MCF-7_Human1.41550904
41AR_21572438_ChIP-Seq_LNCaP_Human1.39922628
42P300_19829295_ChIP-Seq_ESCs_Human1.37015097
43OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36985306
44ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34664689
45TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.34561725
46ER_23166858_ChIP-Seq_MCF-7_Human1.32190436
47MYB_21317192_ChIP-Seq_ERMYB_Mouse1.32185961
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.31995315
49TCF4_23295773_ChIP-Seq_U87_Human1.31625807
50VDR_24787735_ChIP-Seq_THP-1_Human1.31137409
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28986273
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28665724
53CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26754340
54PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26096248
55FLI1_21867929_ChIP-Seq_TH2_Mouse1.26028321
56TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23149404
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22548602
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.21995689
59RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.21911623
60CTNNB1_20460455_ChIP-Seq_HCT116_Human1.18735591
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.17144766
62PRDM14_20953172_ChIP-Seq_ESCs_Human1.16331150
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16025159
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11768752
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11399244
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.11283624
67CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10190534
68TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.09280253
69MYB_26560356_Chip-Seq_TH2_Human1.08248769
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.07854614
71NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.07276588
72E2F1_18555785_Chip-Seq_ESCs_Mouse1.06137640
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05522453
74STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05258144
75SPI1_23127762_ChIP-Seq_K562_Human1.04680224
76FUS_26573619_Chip-Seq_HEK293_Human1.04137630
77IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03650100
78OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03508589
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03320506
80EWS_26573619_Chip-Seq_HEK293_Human1.03177661
81BCAT_22108803_ChIP-Seq_LS180_Human1.02741561
82CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02192725
83KDM2B_26808549_Chip-Seq_REH_Human1.01884573
84RUNX2_22187159_ChIP-Seq_PCA_Human1.01447351
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01017572
86TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00832967
87DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.00128679
88DROSHA_22980978_ChIP-Seq_HELA_Human0.99640756
89FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99313940
90CMYC_18555785_Chip-Seq_ESCs_Mouse0.99194837
91TCF4_18268006_ChIP-ChIP_LS174T_Human0.97797639
92P53_22387025_ChIP-Seq_ESCs_Mouse0.97453490
93MYB_26560356_Chip-Seq_TH1_Human0.96716977
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96220256
95CBP_20019798_ChIP-Seq_JUKART_Human0.95884763
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95884763
97NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95667736
98GATA3_27048872_Chip-Seq_THYMUS_Human0.95042934
99ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95025709
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92856210

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation7.49459471
2MP0003787_abnormal_imprinting6.37639098
3MP0008057_abnormal_DNA_replication4.78796854
4MP0008877_abnormal_DNA_methylation4.00805251
5MP0003724_increased_susceptibility_to3.11884281
6MP0003121_genomic_imprinting3.00893936
7MP0002396_abnormal_hematopoietic_system2.58887776
8MP0004381_abnormal_hair_follicle2.47392953
9MP0005174_abnormal_tail_pigmentation2.25517078
10MP0000015_abnormal_ear_pigmentation2.18675602
11MP0003172_abnormal_lysosome_physiology2.07869176
12MP0003890_abnormal_embryonic-extraembry1.99312372
13MP0001835_abnormal_antigen_presentation1.98260778
14MP0003303_peritoneal_inflammation1.88287207
15MP0001800_abnormal_humoral_immune1.84884965
16MP0008260_abnormal_autophagy1.82776267
17MP0003763_abnormal_thymus_physiology1.79407872
18MP0004883_abnormal_blood_vessel1.65938097
19MP0005409_darkened_coat_color1.47387616
20MP0003828_pulmonary_edema1.44032726
21MP0002419_abnormal_innate_immunity1.43301475
22MP0002166_altered_tumor_susceptibility1.40246090
23MP0000685_abnormal_immune_system1.36264694
24MP0002420_abnormal_adaptive_immunity1.35989862
25MP0002723_abnormal_immune_serum1.35084945
26MP0003183_abnormal_peptide_metabolism1.34958069
27MP0001819_abnormal_immune_cell1.32552435
28MP0006292_abnormal_olfactory_placode1.29677687
29MP0002452_abnormal_antigen_presenting1.28427029
30MP0002398_abnormal_bone_marrow1.28176881
31MP0005076_abnormal_cell_differentiation1.26288822
32MP0004130_abnormal_muscle_cell1.25760648
33MP0003221_abnormal_cardiomyocyte_apopto1.25425048
34MP0004808_abnormal_hematopoietic_stem1.24630475
35MP0002009_preneoplasia1.23694572
36MP0000427_abnormal_hair_cycle1.23185544
37MP0000778_abnormal_nervous_system1.21955839
38MP0006054_spinal_hemorrhage1.21048741
39MP0003122_maternal_imprinting1.20667363
40MP0000703_abnormal_thymus_morphology1.18570767
41MP0003436_decreased_susceptibility_to1.18378215
42MP0002405_respiratory_system_inflammati1.15670349
43MP0000716_abnormal_immune_system1.14397415
44MP0003300_gastrointestinal_ulcer1.11412331
45MP0005310_abnormal_salivary_gland1.10718384
46MP0002928_abnormal_bile_duct1.07659134
47MP0003632_abnormal_nervous_system1.06783926
48MP0003091_abnormal_cell_migration1.06448481
49MP0005075_abnormal_melanosome_morpholog1.06237383
50MP0005387_immune_system_phenotype1.03110363
51MP0001790_abnormal_immune_system1.03110363
52MP0003690_abnormal_glial_cell1.02093156
53MP0000428_abnormal_craniofacial_morphol1.00090924
54MP0000689_abnormal_spleen_morphology0.98806585
55MP0000371_diluted_coat_color0.98246400
56MP0005000_abnormal_immune_tolerance0.96310810
57MP0004484_altered_response_of0.95509099
58MP0002722_abnormal_immune_system0.95005213
59MP0005164_abnormal_response_to0.94891029
60MP0005025_abnormal_response_to0.93441935
61MP0003045_fibrosis0.92944954
62MP0005671_abnormal_response_to0.92789845
63MP0003656_abnormal_erythrocyte_physiolo0.90177164
64MP0002909_abnormal_adrenal_gland0.89959608
65MP0002006_tumorigenesis0.89731517
66MP0001188_hyperpigmentation0.89177216
67MP0002638_abnormal_pupillary_reflex0.85560142
68MP0001851_eye_inflammation0.83003044
69MP0003866_abnormal_defecation0.81799427
70MP0010307_abnormal_tumor_latency0.80989250
71MP0004142_abnormal_muscle_tone0.78542267
72MP0008961_abnormal_basal_metabolism0.78388269
73MP0002332_abnormal_exercise_endurance0.77912567
74MP0004885_abnormal_endolymph0.75820942
75MP0003631_nervous_system_phenotype0.75048540
76MP0002429_abnormal_blood_cell0.74603340
77MP0009115_abnormal_fat_cell0.73207924
78MP0000383_abnormal_hair_follicle0.70869130
79MP0002095_abnormal_skin_pigmentation0.70044233
80MP0003635_abnormal_synaptic_transmissio0.68957561
81MP0001958_emphysema0.64588998
82MP0002063_abnormal_learning/memory/cond0.63543964
83MP0002133_abnormal_respiratory_system0.63440684
84MP0005388_respiratory_system_phenotype0.63440684
85MP0001545_abnormal_hematopoietic_system0.63278883
86MP0005397_hematopoietic_system_phenotyp0.63278883
87MP0003633_abnormal_nervous_system0.62811125
88MP0004811_abnormal_neuron_physiology0.62522675
89MP0005621_abnormal_cell_physiology0.61867651
90MP0003115_abnormal_respiratory_system0.60787545
91MP0002067_abnormal_sensory_capabilities0.60276160
92MP0001186_pigmentation_phenotype0.54697717
93MP0000955_abnormal_spinal_cord0.54695979
94MP0004742_abnormal_vestibular_system0.53576464
95MP0001440_abnormal_grooming_behavior0.52467209
96MP0002998_abnormal_bone_remodeling0.51895226
97MP0010678_abnormal_skin_adnexa0.51890557
98MP0002168_other_aberrant_phenotype0.51136814
99MP0001784_abnormal_fluid_regulation0.48694846
100MP0001486_abnormal_startle_reflex0.48408131

Predicted human phenotypes

RankGene SetZ-score
1Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.07600723
2Papillary thyroid carcinoma (HP:0002895)3.98120858
3Volvulus (HP:0002580)3.83476509
4Subacute progressive viral hepatitis (HP:0006572)3.37053155
5Recurrent bacterial skin infections (HP:0005406)3.36677333
6T lymphocytopenia (HP:0005403)3.27298941
7Optic neuritis (HP:0100653)3.21903427
8Retrobulbar optic neuritis (HP:0100654)3.21903427
9Genetic anticipation (HP:0003743)3.15691685
10Abnormality of T cell number (HP:0011839)3.01717302
11Difficulty running (HP:0009046)2.95618770
12Orchitis (HP:0100796)2.87532432
13Truncal obesity (HP:0001956)2.87440083
14Eczematoid dermatitis (HP:0000976)2.75370458
15Hyperventilation (HP:0002883)2.74428735
16Recurrent abscess formation (HP:0002722)2.67977767
17Myositis (HP:0100614)2.64795920
18Peritonitis (HP:0002586)2.59110165
19Abnormality of incisor morphology (HP:0011063)2.54111096
20Recurrent fungal infections (HP:0002841)2.50050090
21Hip dysplasia (HP:0001385)2.49493252
22Aqueductal stenosis (HP:0002410)2.48386270
23Abnormal hair whorl (HP:0010721)2.44237515
24Protruding tongue (HP:0010808)2.42125933
25Narrow palate (HP:0000189)2.42044835
26Acute myeloid leukemia (HP:0004808)2.39657847
27Keratoconjunctivitis sicca (HP:0001097)2.35860138
28Abnormality of the fingertips (HP:0001211)2.34228089
29Gastrointestinal infarctions (HP:0005244)2.34126750
30Tapered finger (HP:0001182)2.30401168
31Neoplasm of the tracheobronchial system (HP:0100552)2.29890560
32Viral hepatitis (HP:0006562)2.28673421
33Low anterior hairline (HP:0000294)2.27510708
34Papilledema (HP:0001085)2.27446088
35Widely spaced teeth (HP:0000687)2.26988145
36Gingivitis (HP:0000230)2.20509314
37Stomach cancer (HP:0012126)2.19068138
38Recurrent cutaneous fungal infections (HP:0011370)2.19011642
39Chronic mucocutaneous candidiasis (HP:0002728)2.19011642
40Thyroid carcinoma (HP:0002890)2.17839252
41Absent frontal sinuses (HP:0002688)2.16477221
42Keratoconjunctivitis (HP:0001096)2.16126292
43Abnormality of the ischium (HP:0003174)2.15787973
44Postural instability (HP:0002172)2.12881977
45Overgrowth (HP:0001548)2.11827750
46Abnormal delayed hypersensitivity skin test (HP:0002963)2.11175220
47Hepatoblastoma (HP:0002884)2.09383591
48Spontaneous hematomas (HP:0007420)2.08420576
49Recurrent skin infections (HP:0001581)2.08185712
50Febrile seizures (HP:0002373)2.07053257
51Vertebral arch anomaly (HP:0008438)2.06885576
52Cystic hygroma (HP:0000476)2.04333082
53Neonatal hypoglycemia (HP:0001998)2.01631950
54Recurrent gram-negative bacterial infections (HP:0005420)2.00779000
55Long eyelashes (HP:0000527)2.00364372
56Hypoplastic ischia (HP:0003175)1.99722869
57Gaze-evoked nystagmus (HP:0000640)1.95507443
58Progressive cerebellar ataxia (HP:0002073)1.95484138
59Fair hair (HP:0002286)1.94271224
60Oligodactyly (hands) (HP:0001180)1.93936508
61Heterotopia (HP:0002282)1.93828323
62Inappropriate behavior (HP:0000719)1.92964011
63Hypochromic microcytic anemia (HP:0004840)1.92961951
64Excessive salivation (HP:0003781)1.92028501
65Prominent nose (HP:0000448)1.91563408
66Generalized hypopigmentation of hair (HP:0011358)1.90610363
67Macroorchidism (HP:0000053)1.90547962
68Drooling (HP:0002307)1.88262166
69Stomatitis (HP:0010280)1.83657043
70Leukocytosis (HP:0001974)1.82495411
71Tented upper lip vermilion (HP:0010804)1.80832069
72Sandal gap (HP:0001852)1.80732037
73Thyroiditis (HP:0100646)1.79491117
74Curly hair (HP:0002212)1.78440548
75Supernumerary ribs (HP:0005815)1.77995738
76Encephalitis (HP:0002383)1.76368137
77Acute lymphatic leukemia (HP:0006721)1.73937663
78Aplasia/Hypoplasia of the macula (HP:0008059)1.73819307
79Hemoptysis (HP:0002105)1.72181825
80Obstructive sleep apnea (HP:0002870)1.71233510
81Thick eyebrow (HP:0000574)1.70128983
82Absent speech (HP:0001344)1.68817798
83Dislocated radial head (HP:0003083)1.68277569
84Hypoplasia of the maxilla (HP:0000327)1.66686566
85Arterial thrombosis (HP:0004420)1.65785381
86Supernumerary bones of the axial skeleton (HP:0009144)1.64742250
87Abnormality of the radial head (HP:0003995)1.64020987
88Bladder neoplasm (HP:0009725)1.63973094
89Bladder carcinoma (HP:0002862)1.63973094
90Transitional cell carcinoma of the bladder (HP:0006740)1.61815071
91Abnormality of the right ventricle (HP:0001707)1.61658498
92Neoplasm of the adrenal cortex (HP:0100641)1.61593195
93Keratitis (HP:0000491)1.61343199
94Chest pain (HP:0100749)1.60619222
95Gingival bleeding (HP:0000225)1.60081175
96Vasculitis (HP:0002633)1.59182064
97Obsessive-compulsive behavior (HP:0000722)1.59138330
98Mediastinal lymphadenopathy (HP:0100721)1.58017833
99Abnormality of T cells (HP:0002843)1.57789367
100Hypoplastic iliac wings (HP:0002866)1.57207162

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.37391313
2RIPK42.47458626
3SGK22.15104470
4WNK12.09991831
5TAOK32.06900399
6BLK1.95646658
7CSK1.89338551
8CDK121.88539079
9TNIK1.80425078
10CAMK1G1.72006666
11FES1.70365189
12BRD41.70347401
13AKT31.66933217
14BMPR1B1.64682189
15SGK31.64268551
16MAP3K61.58490172
17MARK21.54454379
18IRAK41.50677378
19CAMK1D1.49003884
20FGFR31.46901313
21YES11.42332479
22SGK4941.39280069
23SGK2231.39280069
24PTK2B1.36157252
25CASK1.35042936
26FGR1.31630720
27ACVR1B1.30216075
28IRAK11.29938090
29MAP3K141.28332373
30MAP3K21.26398535
31PAK31.24089511
32JAK11.23738895
33TEC1.23720843
34PIK3CG1.23476551
35NLK1.19846968
36BTK1.19196444
37IKBKE1.18189864
38MAP4K11.16774035
39SIK21.12985632
40SYK1.10874930
41MAP2K31.08785103
42MAP2K41.04048719
43PNCK1.03060829
44SGK10.99617135
45STK110.98089520
46NTRK30.97799643
47JAK30.97464459
48HCK0.96860591
49MAPK130.95928741
50IRAK20.95461537
51TXK0.93640993
52HIPK20.93588856
53PDGFRB0.89553159
54KSR10.88696520
55TYK20.87093860
56DMPK0.87008951
57ERBB20.82440927
58MAP3K130.81778293
59JAK20.81310222
60WNK30.80832754
61GRK60.79712511
62DYRK1A0.79509734
63NUAK10.79149458
64MAP3K40.79145434
65RAF10.78507673
66MARK30.76976425
67TNK20.75237406
68MAP3K70.75083204
69FGFR20.73733313
70MKNK20.71452119
71PLK20.70265059
72MARK10.70113904
73LYN0.68217552
74ITK0.67050182
75CAMKK20.66549139
76NTRK20.63316900
77TRPM70.61687180
78BMPR20.61417683
79CHUK0.61105844
80EPHB10.60852932
81NEK60.58853280
82CAMK40.56568069
83LCK0.56032019
84TYRO30.55227190
85ZAP700.54978330
86MAP3K10.54946418
87CAMKK10.54433148
88MAP3K100.53515687
89MAPK70.52215510
90MELK0.52043562
91MAPK100.51476663
92PRKCH0.50890861
93OXSR10.50775895
94STK380.50623882
95RET0.49486716
96PRKCZ0.47345580
97STK40.44607082
98STK240.43133171
99PDK10.42167512
100CAMK10.41247517

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043202.16398171
2B cell receptor signaling pathway_Homo sapiens_hsa046621.91356141
3Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.77709300
4Osteoclast differentiation_Homo sapiens_hsa043801.67896957
5Non-small cell lung cancer_Homo sapiens_hsa052231.66696050
6NOD-like receptor signaling pathway_Homo sapiens_hsa046211.54025689
7Leishmaniasis_Homo sapiens_hsa051401.53439971
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.51689023
9T cell receptor signaling pathway_Homo sapiens_hsa046601.50438027
10Renal cell carcinoma_Homo sapiens_hsa052111.46012698
11Phosphatidylinositol signaling system_Homo sapiens_hsa040701.36946161
12Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.36230726
13Endometrial cancer_Homo sapiens_hsa052131.35563264
14FoxO signaling pathway_Homo sapiens_hsa040681.35152984
15Prolactin signaling pathway_Homo sapiens_hsa049171.31754410
16Long-term potentiation_Homo sapiens_hsa047201.31725373
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.29418371
18Measles_Homo sapiens_hsa051621.28677400
19Acute myeloid leukemia_Homo sapiens_hsa052211.26429402
20Pancreatic cancer_Homo sapiens_hsa052121.24394680
21Platelet activation_Homo sapiens_hsa046111.23696854
22Chemokine signaling pathway_Homo sapiens_hsa040621.23540749
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.23042247
24Chronic myeloid leukemia_Homo sapiens_hsa052201.21837621
25ErbB signaling pathway_Homo sapiens_hsa040121.21832672
26Neurotrophin signaling pathway_Homo sapiens_hsa047221.21489444
27Tuberculosis_Homo sapiens_hsa051521.21104503
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.20627837
29mTOR signaling pathway_Homo sapiens_hsa041501.19705392
30Inositol phosphate metabolism_Homo sapiens_hsa005621.17555360
31Colorectal cancer_Homo sapiens_hsa052101.16937027
32Notch signaling pathway_Homo sapiens_hsa043301.13483800
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.12643569
34Hepatitis B_Homo sapiens_hsa051611.10765634
35Cholinergic synapse_Homo sapiens_hsa047251.06361030
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05790591
37Glioma_Homo sapiens_hsa052141.04368766
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04332092
39Type II diabetes mellitus_Homo sapiens_hsa049301.03265070
40Prostate cancer_Homo sapiens_hsa052151.02464613
41GnRH signaling pathway_Homo sapiens_hsa049121.02457192
42Phospholipase D signaling pathway_Homo sapiens_hsa040721.01050280
43MicroRNAs in cancer_Homo sapiens_hsa052060.99709555
44Choline metabolism in cancer_Homo sapiens_hsa052310.97038846
45VEGF signaling pathway_Homo sapiens_hsa043700.95481803
46Toxoplasmosis_Homo sapiens_hsa051450.95017980
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93876651
48Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93335844
49Long-term depression_Homo sapiens_hsa047300.93014165
50MAPK signaling pathway_Homo sapiens_hsa040100.91491251
51TNF signaling pathway_Homo sapiens_hsa046680.91362253
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89980693
53Estrogen signaling pathway_Homo sapiens_hsa049150.89048907
54Influenza A_Homo sapiens_hsa051640.88638867
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.88043089
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87356101
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86160847
58Longevity regulating pathway - mammal_Homo sapiens_hsa042110.86038307
59cAMP signaling pathway_Homo sapiens_hsa040240.84703495
60Oxytocin signaling pathway_Homo sapiens_hsa049210.83943769
61Lysine degradation_Homo sapiens_hsa003100.83311001
62Staphylococcus aureus infection_Homo sapiens_hsa051500.82038785
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81819377
64Hepatitis C_Homo sapiens_hsa051600.81039664
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80106993
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79658123
67Nicotine addiction_Homo sapiens_hsa050330.79223083
68Circadian rhythm_Homo sapiens_hsa047100.77787410
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77579722
70Morphine addiction_Homo sapiens_hsa050320.77565548
71Malaria_Homo sapiens_hsa051440.75131076
72Axon guidance_Homo sapiens_hsa043600.74912185
73Glutamatergic synapse_Homo sapiens_hsa047240.74616830
74Ras signaling pathway_Homo sapiens_hsa040140.73382452
75Rap1 signaling pathway_Homo sapiens_hsa040150.73133841
76Dopaminergic synapse_Homo sapiens_hsa047280.71578683
77Insulin resistance_Homo sapiens_hsa049310.70056465
78Herpes simplex infection_Homo sapiens_hsa051680.68848583
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.67719313
80Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.67571646
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66711533
82Legionellosis_Homo sapiens_hsa051340.66015651
83Primary immunodeficiency_Homo sapiens_hsa053400.65407778
84Circadian entrainment_Homo sapiens_hsa047130.65259977
85Adherens junction_Homo sapiens_hsa045200.65214828
86HIF-1 signaling pathway_Homo sapiens_hsa040660.65164906
87Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64982102
88Hematopoietic cell lineage_Homo sapiens_hsa046400.63855428
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63323527
90Apoptosis_Homo sapiens_hsa042100.61209368
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60536825
92Proteoglycans in cancer_Homo sapiens_hsa052050.60072304
93Renin secretion_Homo sapiens_hsa049240.59236128
94Serotonergic synapse_Homo sapiens_hsa047260.58744496
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58626270
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58245314
97Wnt signaling pathway_Homo sapiens_hsa043100.57898079
98Pathways in cancer_Homo sapiens_hsa052000.57600686
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.57477578
100Focal adhesion_Homo sapiens_hsa045100.56614366

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