BOD1L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromosome condensation (GO:0030261)9.53438392
2DNA packaging (GO:0006323)9.42972684
3spermatid development (GO:0007286)9.14995445
4spermatid nucleus differentiation (GO:0007289)8.90996202
5single strand break repair (GO:0000012)8.79750314
6microtubule depolymerization (GO:0007019)8.00427161
7plasma membrane fusion (GO:0045026)7.71893007
8negative regulation of inclusion body assembly (GO:0090084)7.65634867
9sperm-egg recognition (GO:0035036)7.56493064
10phosphatidylethanolamine biosynthetic process (GO:0006646)7.56305461
11response to pheromone (GO:0019236)7.51661680
12sexual reproduction (GO:0019953)7.46163560
13protein polyglutamylation (GO:0018095)7.41009483
14multicellular organism reproduction (GO:0032504)7.34784261
15rRNA methylation (GO:0031167)7.27838662
16reproduction (GO:0000003)7.12220558
17phosphatidylethanolamine metabolic process (GO:0046337)6.98048054
18binding of sperm to zona pellucida (GO:0007339)6.93997881
19microtubule severing (GO:0051013)6.78795588
20calcium ion-dependent exocytosis (GO:0017156)6.56577298
21axonemal dynein complex assembly (GO:0070286)6.27150113
22microtubule polymerization or depolymerization (GO:0031109)6.26651209
23protein targeting to Golgi (GO:0000042)6.22984676
24cell-cell recognition (GO:0009988)6.22612407
25rRNA modification (GO:0000154)6.15162277
26spermatogenesis (GO:0007283)6.09702629
27male gamete generation (GO:0048232)6.07596291
28cellular ketone body metabolic process (GO:0046950)6.02767926
29establishment of protein localization to Golgi (GO:0072600)5.96569645
30regulation of cilium movement (GO:0003352)5.91451427
31retrograde transport, vesicle recycling within Golgi (GO:0000301)5.81397640
32gamete generation (GO:0007276)5.56813250
33regulation of inclusion body assembly (GO:0090083)5.49320490
34ketone body metabolic process (GO:1902224)5.32122539
35RNA destabilization (GO:0050779)5.14779245
36germ cell development (GO:0007281)5.05346367
37single fertilization (GO:0007338)4.99399957
38motile cilium assembly (GO:0044458)4.91318075
39cilium or flagellum-dependent cell motility (GO:0001539)4.85079600
40cell wall macromolecule catabolic process (GO:0016998)4.81727192
41cellular process involved in reproduction in multicellular organism (GO:0022412)4.73139332
42centriole replication (GO:0007099)4.69432268
43positive regulation of Rab GTPase activity (GO:0032851)4.64046843
44regulation of Rab GTPase activity (GO:0032313)4.64046843
45chromatin silencing (GO:0006342)4.61790580
46nucleus organization (GO:0006997)4.53918613
47multicellular organismal reproductive process (GO:0048609)4.50252509
48cell wall macromolecule metabolic process (GO:0044036)4.47990128
49regulation of transcription involved in cell fate commitment (GO:0060850)4.47501655
50regulation of microtubule-based movement (GO:0060632)4.45378662
51protein localization to Golgi apparatus (GO:0034067)4.45371601
52centriole assembly (GO:0098534)4.31656924
53organic cation transport (GO:0015695)4.21780569
54polyamine biosynthetic process (GO:0006596)4.21499080
55epithelial cilium movement (GO:0003351)4.20141664
56fertilization (GO:0009566)4.09151030
57protein-DNA complex disassembly (GO:0032986)4.05037682
58nucleosome disassembly (GO:0006337)4.05037682
59response to acidic pH (GO:0010447)3.91529842
60regulation of centriole replication (GO:0046599)3.69308454
61peptidyl-threonine dephosphorylation (GO:0035970)3.68696622
62cilium movement (GO:0003341)3.63354379
63antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.61969113
64membrane protein intracellular domain proteolysis (GO:0031293)3.60344575
65cellular response to pH (GO:0071467)3.55295774
66multicellular organismal movement (GO:0050879)3.54403754
67musculoskeletal movement (GO:0050881)3.54403754
68homeostasis of number of cells within a tissue (GO:0048873)3.44478101
69coenzyme catabolic process (GO:0009109)3.42082112
70regulation of interleukin-13 production (GO:0032656)3.32535733
71cerebral cortex neuron differentiation (GO:0021895)3.32233467
72negative regulation of Rho protein signal transduction (GO:0035024)3.31535811
73multicellular organismal development (GO:0007275)3.25723881
74regulation of T-helper 2 cell differentiation (GO:0045628)3.20605007
75mitochondrial fission (GO:0000266)3.18056202
76negative regulation of gene expression, epigenetic (GO:0045814)3.14693214
77glycerol ether metabolic process (GO:0006662)3.14098416
78regulation of somitogenesis (GO:0014807)3.12492635
79seminiferous tubule development (GO:0072520)3.10530225
80cranial nerve morphogenesis (GO:0021602)3.10154799
81cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.07331865
82genitalia morphogenesis (GO:0035112)3.04202128
83DNA conformation change (GO:0071103)3.03110734
84histone H3-K9 demethylation (GO:0033169)3.02296309
85regulation of phosphoprotein phosphatase activity (GO:0043666)3.02283400
86protein depolymerization (GO:0051261)2.98421785
87cell recognition (GO:0008037)2.97905420
88ether metabolic process (GO:0018904)2.89221679
89RNA localization (GO:0006403)2.85646805
90histone exchange (GO:0043486)2.82725105
91mitotic G1 DNA damage checkpoint (GO:0031571)2.79260553
92microtubule nucleation (GO:0007020)2.79053265
93cellular biogenic amine biosynthetic process (GO:0042401)2.73533829
94chaperone-mediated protein complex assembly (GO:0051131)2.73337608
95negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.72557642
96positive regulation of guanylate cyclase activity (GO:0031284)2.71799034
97sperm motility (GO:0030317)12.6165818
98acrosome reaction (GO:0007340)12.4603028
99sperm capacitation (GO:0048240)10.1936771
100fusion of sperm to egg plasma membrane (GO:0007342)10.1779011

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.81904966
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.51070422
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.46763621
4POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.35925029
5TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.35925029
6EZH2_22144423_ChIP-Seq_EOC_Human2.30755015
7VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.25687309
8ELF1_20517297_ChIP-Seq_JURKAT_Human2.18228539
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15777623
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.12774953
11CBP_20019798_ChIP-Seq_JUKART_Human2.06158680
12IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.06158680
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05558521
14CTCF_27219007_Chip-Seq_Bcells_Human1.95586369
15CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95441797
16DROSHA_22980978_ChIP-Seq_HELA_Human1.92257294
17EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.89499830
18RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.89339675
19NANOG_20526341_ChIP-Seq_ESCs_Human1.86506699
20ERA_21632823_ChIP-Seq_H3396_Human1.86493605
21RAC3_21632823_ChIP-Seq_H3396_Human1.85350294
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.83914037
23BCL6_27268052_Chip-Seq_Bcells_Human1.78335603
24YY1_22570637_ChIP-Seq_MALME-3M_Human1.74427487
25EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.71593678
26TDRD3_21172665_ChIP-Seq_MCF-7_Human1.71416671
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.69855486
28BCOR_27268052_Chip-Seq_Bcells_Human1.69158559
29SMC4_20622854_ChIP-Seq_HELA_Human1.68741994
30WDR5_24793694_ChIP-Seq_LNCAP_Human1.67789053
31FUS_26573619_Chip-Seq_HEK293_Human1.65162875
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64141015
33P68_20966046_ChIP-Seq_HELA_Human1.63255951
34TAF2_19829295_ChIP-Seq_ESCs_Human1.62500710
35E2F1_20622854_ChIP-Seq_HELA_Human1.62128332
36PHF8_20622854_ChIP-Seq_HELA_Human1.61673410
37LXR_22292898_ChIP-Seq_THP-1_Human1.58424702
38BP1_19119308_ChIP-ChIP_Hs578T_Human1.56456684
39TP63_22573176_ChIP-Seq_HFKS_Human1.52095230
40CTCF_20526341_ChIP-Seq_ESCs_Human1.51955216
41OCT4_20526341_ChIP-Seq_ESCs_Human1.51045176
42AUTS2_25519132_ChIP-Seq_293T-REX_Human1.47775944
43P300_27268052_Chip-Seq_Bcells_Human1.44991144
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43671763
45MYC_19829295_ChIP-Seq_ESCs_Human1.42631615
46ERG_20517297_ChIP-Seq_VCAP_Human1.42302191
47AR_25329375_ChIP-Seq_VCAP_Human1.41611157
48ARNT_22903824_ChIP-Seq_MCF-7_Human1.40745477
49SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40329704
50SMAD4_21741376_ChIP-Seq_EPCs_Human1.39583810
51PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.38632322
52P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.37671304
53EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.37030911
54ER_23166858_ChIP-Seq_MCF-7_Human1.36590975
55RBPJ_21746931_ChIP-Seq_IB4_Human1.34886817
56ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34779396
57DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.34640479
58ETV2_25802403_ChIP-Seq_MESCs_Mouse1.34435299
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34247883
60CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.33216351
61RUNX1_26923725_Chip-Seq_HPCs_Mouse1.32159059
62HNFA_21074721_ChIP-Seq_CACO-2_Human1.31706641
63SUZ12_27294783_Chip-Seq_ESCs_Mouse1.31143884
64SOX2_22085726_ChIP-Seq_NPCs_Mouse1.30526345
65SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.30353515
66CBX2_22325352_ChIP-Seq_293T-Rex_Human1.29793251
67KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.29271379
68SMAD3_21741376_ChIP-Seq_ESCs_Human1.26463946
69ETV1_20927104_ChIP-Seq_GIST48_Human1.24082452
70CEBPB_22108803_ChIP-Seq_LS180_Human1.21477578
71TP53_18474530_ChIP-ChIP_U2OS_Human1.19046693
72SMRT_27268052_Chip-Seq_Bcells_Human1.16716141
73GATA3_21878914_ChIP-Seq_MCF-7_Human1.14858528
74SA1_27219007_Chip-Seq_Bcells_Human1.13625933
75RUNX_20019798_ChIP-Seq_JUKART_Human1.13518816
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.13056751
77P53_21459846_ChIP-Seq_SAOS-2_Human1.12347918
78EZH2_27294783_Chip-Seq_ESCs_Mouse1.12307590
79NFYB_21822215_ChIP-Seq_K562_Human1.11597100
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.11548453
81NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09506693
82TBL1_22424771_ChIP-Seq_293T_Human1.08999261
83PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07525807
84P300_19829295_ChIP-Seq_ESCs_Human1.06369853
85GATA6_21074721_ChIP-Seq_CACO-2_Human1.06309847
86CSB_26484114_Chip-Seq_FIBROBLAST_Human1.05598128
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05163094
88PHF8_20622853_ChIP-Seq_HELA_Human1.04297929
89SA1_27219007_Chip-Seq_ERYTHROID_Human1.04037060
90SMAD4_21741376_ChIP-Seq_HESCs_Human1.03704195
91OCT1_27270436_Chip-Seq_PROSTATE_Human1.03148147
92CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01388366
93OCT4_19829295_ChIP-Seq_ESCs_Human1.00817506
94FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00654043
95TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98071685
96NFYA_21822215_ChIP-Seq_K562_Human0.97886052
97KLF4_19829295_ChIP-Seq_ESCs_Human0.97663977
98SOX2_19829295_ChIP-Seq_ESCs_Human0.96880093
99NANOG_19829295_ChIP-Seq_ESCs_Human0.96880093
100SOX11_22085726_ChIP-Seq_ESNs_Mouse0.96645252

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose5.43796193
2MP0003698_abnormal_male_reproductive4.76967099
3MP0005377_hearing/vestibular/ear_phenot4.76791577
4MP0003878_abnormal_ear_physiology4.76791577
5MP0001929_abnormal_gametogenesis4.17931535
6MP0001348_abnormal_lacrimal_gland3.03036431
7MP0002161_abnormal_fertility/fecundity2.73177656
8MP0000678_abnormal_parathyroid_gland2.39268632
9MP0003718_maternal_effect2.11138550
10MP0003646_muscle_fatigue2.08407522
11MP0005410_abnormal_fertilization13.1039542
12MP0002210_abnormal_sex_determination1.94182242
13MP0003011_delayed_dark_adaptation1.88626144
14MP0002132_abnormal_respiratory_system1.75845241
15MP0002234_abnormal_pharynx_morphology1.62224833
16MP0001145_abnormal_male_reproductive1.58360002
17MP0002249_abnormal_larynx_morphology1.54791800
18MP0005423_abnormal_somatic_nervous1.54106653
19MP0000653_abnormal_sex_gland1.50321079
20MP0002822_catalepsy1.43208311
21MP0001485_abnormal_pinna_reflex1.41547272
22MP0009053_abnormal_anal_canal1.35566822
23MP0005310_abnormal_salivary_gland1.30339695
24MP0005379_endocrine/exocrine_gland_phen1.29691483
25MP0002282_abnormal_trachea_morphology1.28210483
26MP0000534_abnormal_ureter_morphology1.27204592
27MP0004859_abnormal_synaptic_plasticity1.20181461
28MP0001486_abnormal_startle_reflex1.19835599
29MP0002138_abnormal_hepatobiliary_system1.15949240
30MP0002735_abnormal_chemical_nociception1.12732766
31MP0001765_abnormal_ion_homeostasis1.08487582
32MP0003879_abnormal_hair_cell1.06511771
33MP0009115_abnormal_fat_cell1.02640216
34MP0002127_abnormal_cardiovascular_syste1.02181650
35MP0005666_abnormal_adipose_tissue1.00104626
36MP0001963_abnormal_hearing_physiology1.00001261
37MP0001968_abnormal_touch/_nociception0.98836954
38MP0004742_abnormal_vestibular_system0.97742855
39MP0005395_other_phenotype0.96975780
40MP0005451_abnormal_body_composition0.92259513
41MP0008569_lethality_at_weaning0.87870351
42MP0000026_abnormal_inner_ear0.86781822
43MP0002229_neurodegeneration0.85346884
44MP0000955_abnormal_spinal_cord0.84779637
45MP0005248_abnormal_Harderian_gland0.84340479
46MP0008877_abnormal_DNA_methylation0.80209910
47MP0004510_myositis0.79699493
48MP0000681_abnormal_thyroid_gland0.77592985
49MP0005375_adipose_tissue_phenotype0.75515074
50MP0001905_abnormal_dopamine_level0.74673534
51MP0005083_abnormal_biliary_tract0.73818357
52MP0005551_abnormal_eye_electrophysiolog0.72585413
53MP0002557_abnormal_social/conspecific_i0.71685311
54MP0000049_abnormal_middle_ear0.71596284
55MP0002067_abnormal_sensory_capabilities0.71426591
56MP0001879_abnormal_lymphatic_vessel0.68510302
57MP0004085_abnormal_heartbeat0.59824790
58MP0005253_abnormal_eye_physiology0.59381010
59MP0003077_abnormal_cell_cycle0.57129542
60MP0005636_abnormal_mineral_homeostasis0.56946493
61MP0001666_abnormal_nutrient_absorption0.55722488
62MP0003699_abnormal_female_reproductive0.54547918
63MP0005367_renal/urinary_system_phenotyp0.54527265
64MP0000516_abnormal_urinary_system0.54527265
65MP0000613_abnormal_salivary_gland0.53527824
66MP0001270_distended_abdomen0.50210610
67MP0002272_abnormal_nervous_system0.48916553
68MP0000003_abnormal_adipose_tissue0.48841435
69MP0002733_abnormal_thermal_nociception0.48456587
70MP0005647_abnormal_sex_gland0.48455858
71MP0004484_altered_response_of0.46004896
72MP0002572_abnormal_emotion/affect_behav0.45750330
73MP0009745_abnormal_behavioral_response0.45428895
74MP0008961_abnormal_basal_metabolism0.44300321
75MP0001440_abnormal_grooming_behavior0.43729386
76MP0003091_abnormal_cell_migration0.43617532
77MP0010329_abnormal_lipoprotein_level0.42584724
78MP0009697_abnormal_copulation0.40942264
79MP0002734_abnormal_mechanical_nocicepti0.40119950
80MP0003631_nervous_system_phenotype0.39586111
81MP0000249_abnormal_blood_vessel0.39549444
82MP0001873_stomach_inflammation0.39077246
83MP0000470_abnormal_stomach_morphology0.38956948
84MP0003137_abnormal_impulse_conducting0.38925343
85MP0005535_abnormal_body_temperature0.38236250
86MP0002928_abnormal_bile_duct0.37696697
87MP0004036_abnormal_muscle_relaxation0.36892962
88MP0005084_abnormal_gallbladder_morpholo0.36736786
89MP0008995_early_reproductive_senescence0.35826790
90MP0003632_abnormal_nervous_system0.35249546
91MP0004233_abnormal_muscle_weight0.35158993
92MP0003119_abnormal_digestive_system0.34723364
93MP0001970_abnormal_pain_threshold0.34144277
94MP0003936_abnormal_reproductive_system0.33824156
95MP0003880_abnormal_central_pattern0.33234903
96MP0005408_hypopigmentation0.33106028
97MP0003959_abnormal_lean_body0.33102149
98MP0005167_abnormal_blood-brain_barrier0.32484572
99MP0001501_abnormal_sleep_pattern0.32061823
100MP0005623_abnormal_meninges_morphology0.31077847

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)8.38978183
2Absent/shortened dynein arms (HP:0200106)6.00556180
3Dynein arm defect of respiratory motile cilia (HP:0012255)6.00556180
4Tubulointerstitial nephritis (HP:0001970)5.61904024
5Hyperkalemia (HP:0002153)5.23146599
6Chronic hepatic failure (HP:0100626)5.12114609
7Bony spicule pigmentary retinopathy (HP:0007737)5.09651859
8Attenuation of retinal blood vessels (HP:0007843)4.97335663
9Resting tremor (HP:0002322)4.77907379
10Asymmetric septal hypertrophy (HP:0001670)4.65658136
11Abnormal ciliary motility (HP:0012262)4.62721699
12Abnormal respiratory motile cilium physiology (HP:0012261)4.58630495
13Infertility (HP:0000789)4.47535601
14Abnormal respiratory epithelium morphology (HP:0012253)4.47119786
15Abnormal respiratory motile cilium morphology (HP:0005938)4.47119786
16Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.44431124
17Nasal polyposis (HP:0100582)4.35646921
18Abnormality of macular pigmentation (HP:0008002)4.31446423
19Male infertility (HP:0003251)4.16672608
20Potter facies (HP:0002009)4.07244085
21Facial shape deformation (HP:0011334)4.07244085
22Bell-shaped thorax (HP:0001591)4.06747137
23Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.05288808
24Abnormal rod and cone electroretinograms (HP:0008323)4.03543963
25Cone-rod dystrophy (HP:0000548)3.91375342
26Hypoalphalipoproteinemia (HP:0003233)3.55692852
27Abnormality of the nasal mucosa (HP:0000433)3.54687959
28Hypoplasia of the thymus (HP:0000778)3.49282363
29Progressive sensorineural hearing impairment (HP:0000408)3.43842557
30Azoospermia (HP:0000027)3.42554010
31Abnormal spermatogenesis (HP:0008669)3.39694013
32Impulsivity (HP:0100710)3.33085156
33Aplasia/Hypoplasia of the earlobes (HP:0009906)3.26766844
34Hypoplastic ischia (HP:0003175)3.20336006
35Postural instability (HP:0002172)3.18059517
36Unilateral renal agenesis (HP:0000122)3.06594147
37Menstrual irregularities (HP:0000858)3.05121086
38Enlarged epiphyses (HP:0010580)2.96364140
39Renovascular hypertension (HP:0100817)2.95765174
40Truncal obesity (HP:0001956)2.95145956
41Congenital malformation of the right heart (HP:0011723)2.92347071
42Double outlet right ventricle (HP:0001719)2.92347071
43Abnormality of the ischium (HP:0003174)2.86983676
44Abnormality of the aortic arch (HP:0012303)2.85940335
45Rhinitis (HP:0012384)2.85851383
46Abnormality of potassium homeostasis (HP:0011042)2.83444203
47Renal dysplasia (HP:0000110)2.82940365
48Insulin-resistant diabetes mellitus (HP:0000831)2.79930020
49Abnormal urine output (HP:0012590)2.75146439
50Generalized aminoaciduria (HP:0002909)2.73883305
51Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.56480098
52Amelogenesis imperfecta (HP:0000705)2.55431391
53Progressive cerebellar ataxia (HP:0002073)2.53708766
54Nephronophthisis (HP:0000090)2.51959899
55Tubulointerstitial abnormality (HP:0001969)2.51681944
56Portal hypertension (HP:0001409)2.50898561
57Abnormality of renal excretion (HP:0011036)2.37509019
58Abnormality of the parathyroid morphology (HP:0011766)2.34191636
59Abnormality of the costochondral junction (HP:0000919)2.32856479
60Stage 5 chronic kidney disease (HP:0003774)2.32493168
61Abnormality of dental color (HP:0011073)2.29232160
62Abnormality of the hepatic vasculature (HP:0006707)2.29207543
63Abnormal drinking behavior (HP:0030082)2.23006166
64Polydipsia (HP:0001959)2.23006166
65Myokymia (HP:0002411)2.22794921
66Flattened epiphyses (HP:0003071)2.20893878
67Increased purine levels (HP:0004368)2.18750376
68Hyperuricemia (HP:0002149)2.18750376
69Progressive hearing impairment (HP:0001730)2.16566281
70Abnormality of the renal medulla (HP:0100957)2.12966906
71Polyuria (HP:0000103)2.11727506
72Osteomalacia (HP:0002749)2.08644190
73Bronchiectasis (HP:0002110)2.07906467
74Tetany (HP:0001281)2.05319174
75Chronic bronchitis (HP:0004469)2.03745227
76Recurrent pneumonia (HP:0006532)2.02218201
77Ventricular tachycardia (HP:0004756)2.01789136
78Widely patent fontanelles and sutures (HP:0004492)1.99430542
79Aplasia/Hypoplasia of the sacrum (HP:0008517)1.97316188
80Peripheral hypomyelination (HP:0007182)1.95820636
81Hyponatremia (HP:0002902)1.95603170
82Transposition of the great arteries (HP:0001669)1.94657059
83Abnormal connection of the cardiac segments (HP:0011545)1.94657059
84Abnormal ventriculo-arterial connection (HP:0011563)1.94657059
85Epiphyseal dysplasia (HP:0002656)1.94482648
86Optic nerve hypoplasia (HP:0000609)1.91447156
87Subcapsular cataract (HP:0000523)1.87275036
88Abnormality of the epiphysis of the femoral head (HP:0010574)1.85229130
89Abnormality of chloride homeostasis (HP:0011422)1.83468926
90Hyperthyroidism (HP:0000836)1.81385897
91Hypophosphatemic rickets (HP:0004912)1.79720206
92Neoplasm of the heart (HP:0100544)1.79691173
93Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.77713327
94Absent epiphyses (HP:0010577)1.77713327
95Flat capital femoral epiphysis (HP:0003370)1.77505315
96Renal Fanconi syndrome (HP:0001994)1.77324852
97Upper limb muscle weakness (HP:0003484)1.74466779
98Hypoparathyroidism (HP:0000829)1.72599783
99Amblyopia (HP:0000646)1.72437991
100Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.71628352

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK47.40012693
2TESK16.62263867
3STK384.54710051
4DDR24.36925034
5PNCK3.57911735
6MAP4K23.36868535
7PRKD33.15822329
8STK38L2.99681403
9BRD42.80741533
10PLK22.64727088
11CAMK1G2.62542625
12MAPK152.61537125
13INSRR2.42552693
14MST1R2.05544715
15PDPK11.78134178
16DYRK1B1.75164602
17PDK11.59908141
18NEK61.57627003
19WNK11.43632019
20CDK121.34855231
21PIK3CG1.23576696
22CDK71.18498182
23AKT31.16731999
24KSR21.10052389
25MAP3K91.09912705
26SIK21.00978444
27PTK2B0.98023932
28WNK40.96261810
29BRAF0.87876150
30CAMK1D0.84425386
31RIPK40.84260828
32STK390.80892584
33MAP3K110.74705006
34UHMK10.72848305
35MAP2K20.72562527
36LATS20.71797050
37RPS6KA10.71717406
38MAP3K20.71386811
39RPS6KA20.68046941
40PRKG10.65937686
41MAP3K80.64161575
42PRKG20.62667216
43ROCK10.62618220
44SGK2230.61042338
45SGK4940.61042338
46TYRO30.60670424
47CAMK10.56817816
48GSK3B0.52296960
49CDK20.50511741
50CDK30.48453849
51LATS10.48196119
52PRKAA20.47810658
53MAP3K10.47666630
54BMPR1B0.46260396
55MTOR0.46103856
56PINK10.45989574
57CDK40.45806053
58MAPK80.44472739
59CDK10.43761387
60TESK20.42076563
61MAPK10.41800971
62SGK10.37452194
63PRKCZ0.35936638
64ARAF0.35241234
65MET0.34167765
66RPS6KL10.33826069
67RPS6KC10.33826069
68CAMK40.31850804
69CHEK10.31787365
70RPS6KA60.31448904
71MINK10.28635002
72PRKCG0.27599537
73MAPK140.27016285
74PRKCB0.24743809
75MAPK100.24666807
76NEK20.24017729
77NTRK30.22892002
78MARK10.22762971
79OXSR10.18647390
80MUSK0.18547414
81AKT10.16490087
82BRSK10.16384715
83MAPK110.15217465
84MARK20.15029200
85TNIK0.14802247
86FER0.13054267
87PKN10.12101003
88TIE10.12000173
89MAP3K40.11783880
90SGK20.10678017
91ACVR1B0.09644867
92PRKACB0.09215503
93PRKAA10.09101733
94PRKACA0.07828341
95DYRK20.07115725
96PRKCQ0.06704134
97MAPK90.06125624
98DYRK30.05743973
99ZAK0.05577233
100PRKCA0.05124408

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000728.15180162
2Fatty acid biosynthesis_Homo sapiens_hsa000617.68671787
3Olfactory transduction_Homo sapiens_hsa047402.98814746
4Butanoate metabolism_Homo sapiens_hsa006502.69133161
5Glycerophospholipid metabolism_Homo sapiens_hsa005642.18660074
6Fatty acid degradation_Homo sapiens_hsa000712.16246619
7Fatty acid metabolism_Homo sapiens_hsa012122.01767981
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.80891006
9Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.79534714
10Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.77990422
11Dorso-ventral axis formation_Homo sapiens_hsa043201.77163042
12Adipocytokine signaling pathway_Homo sapiens_hsa049201.50537468
13Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.49950574
14Type II diabetes mellitus_Homo sapiens_hsa049301.49126064
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.35516432
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.34907652
17Taste transduction_Homo sapiens_hsa047421.34325270
18RNA transport_Homo sapiens_hsa030131.33713034
19Phenylalanine metabolism_Homo sapiens_hsa003601.28722777
20PPAR signaling pathway_Homo sapiens_hsa033201.26426571
21Type I diabetes mellitus_Homo sapiens_hsa049401.23869578
22Antigen processing and presentation_Homo sapiens_hsa046121.18245066
23Allograft rejection_Homo sapiens_hsa053301.08298098
24Endocytosis_Homo sapiens_hsa041441.08200348
25Autoimmune thyroid disease_Homo sapiens_hsa053201.05836372
26Phototransduction_Homo sapiens_hsa047441.04461475
27Arginine and proline metabolism_Homo sapiens_hsa003301.01905448
28Graft-versus-host disease_Homo sapiens_hsa053320.96156358
29Hedgehog signaling pathway_Homo sapiens_hsa043400.92670421
30Morphine addiction_Homo sapiens_hsa050320.92514802
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89492093
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87815526
33Inositol phosphate metabolism_Homo sapiens_hsa005620.86240450
34Salivary secretion_Homo sapiens_hsa049700.85514524
35Selenocompound metabolism_Homo sapiens_hsa004500.82976608
36Arginine biosynthesis_Homo sapiens_hsa002200.81755764
37Circadian entrainment_Homo sapiens_hsa047130.80837062
38Protein digestion and absorption_Homo sapiens_hsa049740.79462253
39Viral myocarditis_Homo sapiens_hsa054160.78928232
40Calcium signaling pathway_Homo sapiens_hsa040200.78539643
41Renin-angiotensin system_Homo sapiens_hsa046140.75193731
42cAMP signaling pathway_Homo sapiens_hsa040240.74680051
43Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72393358
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72250679
45Estrogen signaling pathway_Homo sapiens_hsa049150.71554886
46Synaptic vesicle cycle_Homo sapiens_hsa047210.70360148
47Fat digestion and absorption_Homo sapiens_hsa049750.68363567
48Glycerolipid metabolism_Homo sapiens_hsa005610.68192117
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67930167
50Oocyte meiosis_Homo sapiens_hsa041140.67628033
51ABC transporters_Homo sapiens_hsa020100.63133807
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61296168
53Cardiac muscle contraction_Homo sapiens_hsa042600.60704611
54Influenza A_Homo sapiens_hsa051640.58370952
55Tyrosine metabolism_Homo sapiens_hsa003500.56604288
56Tight junction_Homo sapiens_hsa045300.56354379
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56246489
58Nicotine addiction_Homo sapiens_hsa050330.55070601
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54804141
60Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54028116
61Biosynthesis of amino acids_Homo sapiens_hsa012300.50631808
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50006772
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.48446430
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.46743363
65Glutamatergic synapse_Homo sapiens_hsa047240.46376949
66Purine metabolism_Homo sapiens_hsa002300.45103843
67MAPK signaling pathway_Homo sapiens_hsa040100.44972392
68Renin secretion_Homo sapiens_hsa049240.44890088
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44177118
70Gastric acid secretion_Homo sapiens_hsa049710.44000666
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.41162869
72Retinol metabolism_Homo sapiens_hsa008300.40059835
73Acute myeloid leukemia_Homo sapiens_hsa052210.37260998
74Insulin secretion_Homo sapiens_hsa049110.37245960
75VEGF signaling pathway_Homo sapiens_hsa043700.35615885
76Serotonergic synapse_Homo sapiens_hsa047260.35321491
77Cholinergic synapse_Homo sapiens_hsa047250.35033686
78Bile secretion_Homo sapiens_hsa049760.33650633
79Basal transcription factors_Homo sapiens_hsa030220.33232535
80Nitrogen metabolism_Homo sapiens_hsa009100.32075430
81GABAergic synapse_Homo sapiens_hsa047270.30647714
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.27090871
83Viral carcinogenesis_Homo sapiens_hsa052030.26124843
84Alcoholism_Homo sapiens_hsa050340.25616733
85Pancreatic secretion_Homo sapiens_hsa049720.25510022
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22812689
87Oxytocin signaling pathway_Homo sapiens_hsa049210.21937385
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.21482116
89mRNA surveillance pathway_Homo sapiens_hsa030150.19483600
90Long-term potentiation_Homo sapiens_hsa047200.18097298
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.17989439
92Carbon metabolism_Homo sapiens_hsa012000.16911627
93Legionellosis_Homo sapiens_hsa051340.16367150
94Metabolic pathways_Homo sapiens_hsa011000.15648405
95Prolactin signaling pathway_Homo sapiens_hsa049170.14855497
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.14637164
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.13630535
98Huntingtons disease_Homo sapiens_hsa050160.11677052
99Circadian rhythm_Homo sapiens_hsa047100.11463345
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.11031573

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