BOK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the BCL2 family, members of which form homo- or heterodimers, and act as anti- or proapoptotic regulators that are involved in a wide variety of cellular processes. Studies in rat show that this protein has restricted expression in reproductive tissues, interacts strongly with some antiapoptotic BCL2 proteins, not at all with proapoptotic BCL2 proteins, and induces apoptosis in transfected cells. Thus, this protein represents a proapoptotic member of the BCL2 family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)5.08013715
2low-density lipoprotein particle clearance (GO:0034383)4.69173452
3hemidesmosome assembly (GO:0031581)4.51752262
4lung-associated mesenchyme development (GO:0060484)4.39331731
5triglyceride catabolic process (GO:0019433)4.24598063
6neutral lipid catabolic process (GO:0046461)4.10793781
7acylglycerol catabolic process (GO:0046464)4.10793781
8peptidyl-glutamic acid carboxylation (GO:0017187)3.95454357
9protein carboxylation (GO:0018214)3.95454357
10negative regulation of fibrinolysis (GO:0051918)3.88474526
11establishment of skin barrier (GO:0061436)3.82374001
12protein insertion into membrane (GO:0051205)3.81914993
13purine nucleobase biosynthetic process (GO:0009113)3.79896341
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.68217547
15L-phenylalanine metabolic process (GO:0006558)3.68217547
16regulation of fibrinolysis (GO:0051917)3.67269887
17regulation of plasminogen activation (GO:0010755)3.63420399
18regulation of hippo signaling (GO:0035330)3.60354667
19regulation of water loss via skin (GO:0033561)3.57504420
20urea metabolic process (GO:0019627)3.51970162
21L-phenylalanine catabolic process (GO:0006559)3.43338734
22erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.43338734
23ethanol oxidation (GO:0006069)3.42412629
24urea cycle (GO:0000050)3.39792796
25protein heterotrimerization (GO:0070208)3.26026370
26guanosine-containing compound biosynthetic process (GO:1901070)3.22083058
27ribosomal large subunit biogenesis (GO:0042273)3.21875235
28regulation of cardioblast differentiation (GO:0051890)3.20178969
29maturation of SSU-rRNA (GO:0030490)3.17721047
30regulation of G0 to G1 transition (GO:0070316)3.17264573
31nitrogen cycle metabolic process (GO:0071941)3.15464145
32nucleobase-containing small molecule interconversion (GO:0015949)3.14120034
33nucleobase biosynthetic process (GO:0046112)3.13944613
34viral transcription (GO:0019083)3.13929739
35negative regulation of fatty acid transport (GO:2000192)3.13378982
36glycerolipid catabolic process (GO:0046503)3.11553406
37plasma lipoprotein particle clearance (GO:0034381)3.10687593
38positive regulation of triglyceride lipase activity (GO:0061365)3.08881529
39positive regulation of lipoprotein lipase activity (GO:0051006)3.08881529
40formation of translation preinitiation complex (GO:0001731)3.08069056
41adherens junction assembly (GO:0034333)3.06872688
42translational termination (GO:0006415)3.05756162
43NADH metabolic process (GO:0006734)3.05703440
44regulation of cholesterol biosynthetic process (GO:0045540)3.05683550
45negative regulation of axon extension involved in axon guidance (GO:0048843)3.03081840
46negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.01581012
47epithelial cell-cell adhesion (GO:0090136)3.00775654
48cell-substrate adherens junction assembly (GO:0007045)2.98607678
49focal adhesion assembly (GO:0048041)2.98607678
50respiratory tube development (GO:0030323)2.98070625
51cytoskeletal anchoring at plasma membrane (GO:0007016)2.97618081
52protein retention in ER lumen (GO:0006621)2.97032343
53gonadal mesoderm development (GO:0007506)2.96903301
54membrane budding (GO:0006900)2.95732373
55ethanol metabolic process (GO:0006067)2.95547755
56fatty acid homeostasis (GO:0055089)2.95404711
57positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.93525110
58paraxial mesoderm development (GO:0048339)2.91747119
59lung morphogenesis (GO:0060425)2.91509484
60diacylglycerol metabolic process (GO:0046339)2.91434107
61alpha-linolenic acid metabolic process (GO:0036109)2.91062390
62translational initiation (GO:0006413)2.88992629
63biotin metabolic process (GO:0006768)2.88828805
64fibrinolysis (GO:0042730)2.87868959
65translational elongation (GO:0006414)2.87226810
66negative regulation of catenin import into nucleus (GO:0035414)2.85914106
67ribosome assembly (GO:0042255)2.84557429
68anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.82822164
69ephrin receptor signaling pathway (GO:0048013)2.82429172
70intestinal epithelial cell development (GO:0060576)2.80487509
71regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.79004585
72interferon-gamma secretion (GO:0072643)2.78466651
73regulation of protein activation cascade (GO:2000257)2.78151768
74positive regulation of synapse maturation (GO:0090129)2.77771094
75triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.75360884
76maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.74931113
77lymphangiogenesis (GO:0001946)2.73706832
78negative regulation of lipase activity (GO:0060192)2.73644244
79positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.73465831
80DNA deamination (GO:0045006)2.73292312
81complement activation, alternative pathway (GO:0006957)2.72404493
82folic acid metabolic process (GO:0046655)2.72244260
83retina vasculature morphogenesis in camera-type eye (GO:0061299)2.70806385
84proline metabolic process (GO:0006560)2.69753725
85regulation of glucose import in response to insulin stimulus (GO:2001273)2.69664581
86endothelial cell morphogenesis (GO:0001886)2.69052226
87cellular protein complex disassembly (GO:0043624)2.67273596
88negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.67244680
89negative regulation of ligase activity (GO:0051352)2.67244680
90GTP biosynthetic process (GO:0006183)2.66934900
91synaptic vesicle docking involved in exocytosis (GO:0016081)2.64439380
92regulation of early endosome to late endosome transport (GO:2000641)2.62765887
93barbed-end actin filament capping (GO:0051016)2.62308922
94regulation of complement activation (GO:0030449)2.61877141
95regulation of sequestering of triglyceride (GO:0010889)2.60652945
96G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.60528962
97keratinocyte development (GO:0003334)2.60087693
98regulation of cholesterol homeostasis (GO:2000188)2.60003911
99regulation of cellular amino acid metabolic process (GO:0006521)2.56904374
100keratinocyte proliferation (GO:0043616)2.55665256
101molting cycle (GO:0042303)2.55236933
102hair cycle (GO:0042633)2.55236933
103UTP biosynthetic process (GO:0006228)2.55178613
104triglyceride homeostasis (GO:0070328)2.55148928
105acylglycerol homeostasis (GO:0055090)2.55148928
106negative regulation of cell fate specification (GO:0009996)2.55086504
107regulation of cholesterol esterification (GO:0010872)2.54507517
108regulation of transforming growth factor beta1 production (GO:0032908)2.54499719
109Golgi transport vesicle coating (GO:0048200)2.53335780
110COPI coating of Golgi vesicle (GO:0048205)2.53335780
111triglyceride metabolic process (GO:0006641)2.52847704
112positive regulation of lipid catabolic process (GO:0050996)2.52055489
113negative regulation of microtubule polymerization (GO:0031115)2.51727095
114ventricular cardiac muscle cell development (GO:0055015)2.50139008
115positive regulation of extracellular matrix organization (GO:1903055)2.49885798
116positive regulation of endothelial cell apoptotic process (GO:2000353)2.49873272
117positive regulation of cellular response to insulin stimulus (GO:1900078)2.49289270
118positive regulation of ligase activity (GO:0051351)2.48649710
119proteasome assembly (GO:0043248)2.48507793
120chondrocyte proliferation (GO:0035988)2.47604454
121viral life cycle (GO:0019058)2.47042438
122regulation of tight junction assembly (GO:2000810)2.46613966
123blood coagulation, intrinsic pathway (GO:0007597)2.46148598
124proline biosynthetic process (GO:0006561)2.45404605
125endodermal cell differentiation (GO:0035987)2.44676474
126semaphorin-plexin signaling pathway (GO:0071526)2.44555993
127ribosomal small subunit biogenesis (GO:0042274)2.44324389
128ADP metabolic process (GO:0046031)2.43993455
129UTP metabolic process (GO:0046051)2.43747614
130planar cell polarity pathway involved in neural tube closure (GO:0090179)2.43355175
131negative regulation of complement activation (GO:0045916)2.42551362
132skin morphogenesis (GO:0043589)2.42368701
133fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.42356454
134triglyceride biosynthetic process (GO:0019432)2.41127880
135nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.40926648
136regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.40669475
137neuron projection extension involved in neuron projection guidance (GO:1902284)2.40642455
138axon extension involved in axon guidance (GO:0048846)2.40642455
139apoptotic cell clearance (GO:0043277)2.40348399
140acylglycerol metabolic process (GO:0006639)2.39631912
141keratinization (GO:0031424)2.39620809
142folic acid transport (GO:0015884)2.39128941
143glyoxylate metabolic process (GO:0046487)2.38762340
144insulin-like growth factor receptor signaling pathway (GO:0048009)2.38468022
145negative regulation of blood coagulation (GO:0030195)2.38058287
146negative regulation of hemostasis (GO:1900047)2.38058287
147stress fiber assembly (GO:0043149)2.37961490
148protein complex disassembly (GO:0043241)2.37931713
149L-serine transport (GO:0015825)2.37663910
150regulation of cholesterol metabolic process (GO:0090181)2.37529703
151intermediate filament organization (GO:0045109)2.37056247
152plasma membrane repair (GO:0001778)2.36648809
153negative regulation of axon guidance (GO:1902668)2.36504108
154lymph vessel development (GO:0001945)2.36415269
155negative regulation of lipid transport (GO:0032369)2.35933269
156neutral lipid metabolic process (GO:0006638)2.35019587
157positive regulation of glucose import (GO:0046326)2.34939396
158ribonucleoprotein complex biogenesis (GO:0022613)2.34694976
159protein localization to endosome (GO:0036010)2.34587736
160neutral lipid biosynthetic process (GO:0046460)2.34338910
161acylglycerol biosynthetic process (GO:0046463)2.34338910
162deoxyribonucleotide biosynthetic process (GO:0009263)2.33965210
163hippo signaling (GO:0035329)2.33860190
164water homeostasis (GO:0030104)2.32004259
165oxaloacetate metabolic process (GO:0006107)2.31937345
166glial cell proliferation (GO:0014009)2.31192389
167gap junction assembly (GO:0016264)2.31076151
168regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.30864770
169glutamine family amino acid biosynthetic process (GO:0009084)2.30635311
170regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.30150267
171regulation of ubiquitin-protein transferase activity (GO:0051438)2.30114350
172basement membrane organization (GO:0071711)2.29886934
173atrioventricular valve morphogenesis (GO:0003181)2.29873096
174bundle of His cell to Purkinje myocyte communication (GO:0086069)2.29454882
175multicellular organismal water homeostasis (GO:0050891)2.28262642
176vascular endothelial growth factor signaling pathway (GO:0038084)2.28214190
177negative regulation of keratinocyte proliferation (GO:0010839)2.27327220
178SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.27256732
179macromolecular complex disassembly (GO:0032984)2.26967455
180regulation of synapse maturation (GO:0090128)2.26947440
181cell-substrate junction assembly (GO:0007044)2.26086174
182mesenchymal to epithelial transition (GO:0060231)2.25927865
183primary alcohol catabolic process (GO:0034310)2.24545421
184regulation of triglyceride catabolic process (GO:0010896)2.24048035
185spliceosomal snRNP assembly (GO:0000387)2.23825831
186negative regulation of coagulation (GO:0050819)2.23669008
187nucleoside diphosphate biosynthetic process (GO:0009133)2.23612771
188cell adhesion mediated by integrin (GO:0033627)2.23403824
189negative regulation of wound healing (GO:0061045)2.23267585
190positive regulation of gastrulation (GO:2000543)2.20675935
191translation (GO:0006412)2.20639965
192DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.20389595

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.60148706
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.41078062
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.72710164
4ZNF263_19887448_ChIP-Seq_K562_Human3.19112554
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.07284102
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.82035548
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.72287969
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.70593456
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.62006909
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.38018114
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.30008618
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.26652480
13* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.25692750
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22493718
15FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.17344754
16TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.05442793
17TRIM28_21343339_ChIP-Seq_HEK293_Human1.98190788
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.93383179
19KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.86202805
20ETS1_20019798_ChIP-Seq_JURKAT_Human1.85667547
21LXR_22158963_ChIP-Seq_LIVER_Mouse1.83985182
22ERG_21242973_ChIP-ChIP_JURKAT_Human1.80625142
23NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.80009200
24* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.75504478
25SRY_22984422_ChIP-ChIP_TESTIS_Rat1.72334134
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.69339698
27ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.69148229
28UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.68881870
29ATF3_27146783_Chip-Seq_COLON_Human1.66077635
30KDM2B_26808549_Chip-Seq_SUP-B15_Human1.65860610
31TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.65053627
32XRN2_22483619_ChIP-Seq_HELA_Human1.61671962
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.60637618
34KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.59292863
35* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.59189203
36ZFP281_18757296_ChIP-ChIP_E14_Mouse1.56220633
37TP53_20018659_ChIP-ChIP_R1E_Mouse1.55661496
38JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.54573237
39HIF1A_21447827_ChIP-Seq_MCF-7_Human1.53700578
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.53105462
41PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.52885241
42SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.50947843
43ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.50821655
44* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.42964697
45RACK7_27058665_Chip-Seq_MCF-7_Human1.41439183
46DNAJC2_21179169_ChIP-ChIP_NT2_Human1.38654655
47NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.38642295
48HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.38502568
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.35894708
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.35594025
51P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35468560
52SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.34134314
53TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.33562639
54CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31084741
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30778279
56CTCF_27219007_Chip-Seq_Bcells_Human1.28572913
57CLOCK_20551151_ChIP-Seq_293T_Human1.27936069
58* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.27674534
59NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.26391757
60TET1_21490601_ChIP-Seq_MESCs_Mouse1.26056904
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25402411
62ESR1_21235772_ChIP-Seq_MCF-7_Human1.25014826
63ELK1_22589737_ChIP-Seq_MCF10A_Human1.24736856
64TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24525797
65ESR1_20079471_ChIP-ChIP_T-47D_Human1.23841121
66SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23727621
67NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23161974
68KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23098098
69OCT4_18692474_ChIP-Seq_MEFs_Mouse1.23012867
70TTF2_22483619_ChIP-Seq_HELA_Human1.21944862
71* ELK3_25401928_ChIP-Seq_HUVEC_Human1.21900345
72TBX20_22328084_ChIP-Seq_HEART_Mouse1.20681531
73TBX20_22080862_ChIP-Seq_HEART_Mouse1.20681531
74SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.19852754
75SMC4_20622854_ChIP-Seq_HELA_Human1.19158453
76E2F1_18555785_ChIP-Seq_MESCs_Mouse1.18990867
77KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18281865
78MTF2_20144788_ChIP-Seq_MESCs_Mouse1.17054471
79LXR_22292898_ChIP-Seq_THP-1_Human1.16921490
80FOXM1_23109430_ChIP-Seq_U2OS_Human1.16921042
81ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14771981
82KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.13250809
83DCP1A_22483619_ChIP-Seq_HELA_Human1.12538815
84* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.12094985
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11753512
86TCF3_18692474_ChIP-Seq_MEFs_Mouse1.10792397
87EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.10546849
88KDM2B_26808549_Chip-Seq_DND41_Human1.10023923
89CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09787253
90FOXP1_21924763_ChIP-Seq_HESCs_Human1.09297733
91SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09163738
92SOX2_18692474_ChIP-Seq_MEFs_Mouse1.09114597
93EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.08553592
94* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.08520220
95EED_16625203_ChIP-ChIP_MESCs_Mouse1.08278059
96NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07302608
97GATA2_21666600_ChIP-Seq_HMVEC_Human1.07075928
98TET1_21451524_ChIP-Seq_MESCs_Mouse1.07049193
99DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07023910
100SMC1_22415368_ChIP-Seq_MEFs_Mouse1.06870035
101TP53_22127205_ChIP-Seq_IMR90_Human1.06557397
102TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06553142
103* FOXA2_19822575_ChIP-Seq_HepG2_Human1.06481684
104GABP_17652178_ChIP-ChIP_JURKAT_Human1.06320191
105AR_21909140_ChIP-Seq_LNCAP_Human1.06180585
106NANOG_18555785_ChIP-Seq_MESCs_Mouse1.05768147
107PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05596027
108KDM2B_26808549_Chip-Seq_K562_Human1.05471783
109EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05171950
110EZH2_18974828_ChIP-Seq_MESCs_Mouse1.05121153
111RNF2_18974828_ChIP-Seq_MESCs_Mouse1.05121153
112SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.05096646
113RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04334969
114ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04074482
115STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04007375
116SMC3_22415368_ChIP-Seq_MEFs_Mouse1.03379884
117EST1_17652178_ChIP-ChIP_JURKAT_Human1.02801597
118CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02206094
119SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.02202593
120P68_20966046_ChIP-Seq_HELA_Human1.01787080
121ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01785147
122P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01617056
123SA1_27219007_Chip-Seq_ERYTHROID_Human1.01173291
124ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00952390
125* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.99827253
126CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99740021
127RUNX1_27514584_Chip-Seq_MCF-7_Human0.98857991
128KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98828796
129JARID2_20075857_ChIP-Seq_MESCs_Mouse0.98604579
130TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.98508127
131GABP_19822575_ChIP-Seq_HepG2_Human0.98398154
132SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.98174005
133ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.97800425
134SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.97706580
135SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.97706580
136* TCF7_22412390_ChIP-Seq_EML_Mouse0.96294190
137* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96007574
138UBF1/2_26484160_Chip-Seq_HMECs_Human0.95715422
139SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95133842
140CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94706570
141TP53_23651856_ChIP-Seq_MEFs_Mouse0.94626205
142YY1_22570637_ChIP-Seq_MALME-3M_Human0.94608759
143CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94350790
144PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93893007
145KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93462315
146SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.92802912
147CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91729651
148SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90732294
149TP63_22573176_ChIP-Seq_HFKS_Human0.90131439
150PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90118194
151CREB1_26743006_Chip-Seq_LNCaP_Human0.89302218
152YY1_21170310_ChIP-Seq_MESCs_Mouse0.89026349
153KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.88601480
154KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.88601480
155KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.88601480
156WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88044707
157NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.87806628
158CTCF_18555785_ChIP-Seq_MESCs_Mouse0.86859282
159ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.85193060
160SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.84368370
161EZH2_27304074_Chip-Seq_ESCs_Mouse0.82874394

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose3.56637208
2MP0010030_abnormal_orbit_morphology3.21987245
3MP0002796_impaired_skin_barrier3.07309386
4MP0003941_abnormal_skin_development2.85667426
5MP0003705_abnormal_hypodermis_morpholog2.72816729
6MP0010234_abnormal_vibrissa_follicle2.63874029
7MP0002139_abnormal_hepatobiliary_system2.61556558
8MP0005360_urolithiasis2.58424882
9MP0000537_abnormal_urethra_morphology2.51489572
10MP0005666_abnormal_adipose_tissue2.51306139
11MP0009780_abnormal_chondrocyte_physiolo2.35950982
12MP0005275_abnormal_skin_tensile2.32597238
13MP0003693_abnormal_embryo_hatching2.22620215
14MP0003868_abnormal_feces_composition2.18351924
15MP0005375_adipose_tissue_phenotype2.18270387
16MP0005501_abnormal_skin_physiology2.09283184
17MP0004185_abnormal_adipocyte_glucose2.08924627
18MP0004272_abnormal_basement_membrane2.06324192
19MP0002971_abnormal_brown_adipose1.97949309
20MP0003279_aneurysm1.95793581
21MP0005365_abnormal_bile_salt1.94448587
22MP0000003_abnormal_adipose_tissue1.94320631
23MP0010329_abnormal_lipoprotein_level1.89376271
24MP0000762_abnormal_tongue_morphology1.84458601
25MP0009379_abnormal_foot_pigmentation1.83162098
26MP0003191_abnormal_cellular_cholesterol1.82781836
27MP0000751_myopathy1.81245465
28MP0008438_abnormal_cutaneous_collagen1.80068829
29MP0004130_abnormal_muscle_cell1.80044328
30MP0001879_abnormal_lymphatic_vessel1.74565214
31MP0002060_abnormal_skin_morphology1.72004066
32MP0005257_abnormal_intraocular_pressure1.71970945
33MP0004957_abnormal_blastocyst_morpholog1.68602350
34MP0003315_abnormal_perineum_morphology1.67770130
35MP0001542_abnormal_bone_strength1.65155597
36MP0004858_abnormal_nervous_system1.61938359
37MP0003718_maternal_effect1.61108802
38MP0006054_spinal_hemorrhage1.61057508
39MP0003119_abnormal_digestive_system1.60282772
40MP0005409_darkened_coat_color1.59165599
41MP0009840_abnormal_foam_cell1.59068757
42MP0000013_abnormal_adipose_tissue1.57995681
43MP0004859_abnormal_synaptic_plasticity1.56367308
44MP0010352_gastrointestinal_tract_polyps1.56324870
45MP0010368_abnormal_lymphatic_system1.52627996
46MP0005623_abnormal_meninges_morphology1.52138923
47MP0003942_abnormal_urinary_system1.49073090
48MP0002098_abnormal_vibrissa_morphology1.48569904
49MP0000647_abnormal_sebaceous_gland1.46359209
50MP0000049_abnormal_middle_ear1.46038339
51MP0003123_paternal_imprinting1.43219708
52MP0003566_abnormal_cell_adhesion1.42165065
53MP0003111_abnormal_nucleus_morphology1.41814777
54MP0008789_abnormal_olfactory_epithelium1.41793022
55MP0010771_integument_phenotype1.37547888
56MP0008004_abnormal_stomach_pH1.35680502
57MP0002653_abnormal_ependyma_morphology1.31828493
58MP0003755_abnormal_palate_morphology1.31813992
59MP0001849_ear_inflammation1.31697686
60MP0005085_abnormal_gallbladder_physiolo1.31186796
61MP0000767_abnormal_smooth_muscle1.30723709
62MP0009053_abnormal_anal_canal1.30631875
63MP0000566_synostosis1.29429603
64MP0000750_abnormal_muscle_regeneration1.29221784
65MP0003329_amyloid_beta_deposits1.28058384
66MP0003950_abnormal_plasma_membrane1.27252534
67MP0002234_abnormal_pharynx_morphology1.26804241
68MP0005084_abnormal_gallbladder_morpholo1.23326860
69MP0002118_abnormal_lipid_homeostasis1.23326161
70MP0005451_abnormal_body_composition1.23204528
71MP0010678_abnormal_skin_adnexa1.23086506
72MP0000383_abnormal_hair_follicle1.22960825
73MP0003091_abnormal_cell_migration1.18567017
74MP0009384_cardiac_valve_regurgitation1.18149826
75MP0001661_extended_life_span1.18081571
76MP0001216_abnormal_epidermal_layer1.17951336
77MP0008932_abnormal_embryonic_tissue1.16706276
78MP0005377_hearing/vestibular/ear_phenot1.16203524
79MP0003878_abnormal_ear_physiology1.16203524
80MP0003385_abnormal_body_wall1.14684560
81MP0002970_abnormal_white_adipose1.13455919
82MP0002111_abnormal_tail_morphology1.13310493
83MP0003690_abnormal_glial_cell1.12281187
84MP0002160_abnormal_reproductive_system1.11503230
85MP0002295_abnormal_pulmonary_circulatio1.10457660
86MP0005058_abnormal_lysosome_morphology1.07890855
87MP0003879_abnormal_hair_cell1.07762308
88MP0003938_abnormal_ear_development1.07375816
89MP0003115_abnormal_respiratory_system1.07265314
90MP0004133_heterotaxia1.06226119
91MP0000467_abnormal_esophagus_morphology1.05949641
92MP0002108_abnormal_muscle_morphology1.05301900
93MP0005508_abnormal_skeleton_morphology1.05177985
94MP0005499_abnormal_olfactory_system1.04457486
95MP0005394_taste/olfaction_phenotype1.04457486
96MP0003959_abnormal_lean_body1.04441990
97MP0001984_abnormal_olfaction1.03891207
98MP0002184_abnormal_innervation1.03790595
99MP0004270_analgesia1.03731384
100MP0005595_abnormal_vascular_smooth1.03568865
101MP0001730_embryonic_growth_arrest1.02101086
102MP0002233_abnormal_nose_morphology1.01511936
103MP0009250_abnormal_appendicular_skeleto1.00728612
104MP0002249_abnormal_larynx_morphology1.00660897
105MP0000534_abnormal_ureter_morphology1.00563221
106MP0005187_abnormal_penis_morphology1.00093707
107MP0008875_abnormal_xenobiotic_pharmacok0.99927120
108MP0000538_abnormal_urinary_bladder0.99497084
109MP0005076_abnormal_cell_differentiation0.99251534
110MP0004782_abnormal_surfactant_physiolog0.98887835
111MP0000427_abnormal_hair_cycle0.98816628
112MP0002089_abnormal_postnatal_growth/wei0.98487429
113MP0009115_abnormal_fat_cell0.97946125
114MP0000377_abnormal_hair_follicle0.97732958
115MP0001915_intracranial_hemorrhage0.93932435
116MP0002876_abnormal_thyroid_physiology0.93581472
117MP0000579_abnormal_nail_morphology0.93519278
118MP0004087_abnormal_muscle_fiber0.93009855
119MP0003937_abnormal_limbs/digits/tail_de0.92967438
120MP0006138_congestive_heart_failure0.92370646
121MP0001958_emphysema0.91759873
122MP0000733_abnormal_muscle_development0.89739707
123MP0000759_abnormal_skeletal_muscle0.88771811
124MP0009672_abnormal_birth_weight0.88722515
125MP0001727_abnormal_embryo_implantation0.86277172
126MP0003453_abnormal_keratinocyte_physiol0.85970939
127MP0005023_abnormal_wound_healing0.85747464
128MP0001666_abnormal_nutrient_absorption0.85285736
129MP0004084_abnormal_cardiac_muscle0.84080513
130MP0002896_abnormal_bone_mineralization0.84059066
131MP0003861_abnormal_nervous_system0.83895378
132MP0005334_abnormal_fat_pad0.83437258
133MP0002085_abnormal_embryonic_tissue0.82180127
134MP0002877_abnormal_melanocyte_morpholog0.81523435
135MP0001299_abnormal_eye_distance/0.80126739
136MP0000428_abnormal_craniofacial_morphol0.78979127
137MP0001697_abnormal_embryo_size0.78878607
138MP0005389_reproductive_system_phenotype0.78846972
139MP0005167_abnormal_blood-brain_barrier0.78669163
140MP0001188_hyperpigmentation0.76679981
141MP0003122_maternal_imprinting0.76430696
142MP0002254_reproductive_system_inflammat0.76058999
143MP0004233_abnormal_muscle_weight0.75743707
144MP0000778_abnormal_nervous_system0.75598894
145MP0003567_abnormal_fetal_cardiomyocyte0.74761231
146MP0000462_abnormal_digestive_system0.74709401
147MP0000747_muscle_weakness0.74225199
148MP0001348_abnormal_lacrimal_gland0.72816727
149MP0000358_abnormal_cell_content/0.72585285
150MP0001672_abnormal_embryogenesis/_devel0.72314656
151MP0005380_embryogenesis_phenotype0.72314656
152MP0005503_abnormal_tendon_morphology0.71954327
153MP0000609_abnormal_liver_physiology0.71214512
154MP0010630_abnormal_cardiac_muscle0.70811290
155MP0000920_abnormal_myelination0.70448151
156MP0003828_pulmonary_edema0.69511691
157MP0000749_muscle_degeneration0.69189962
158MP0001243_abnormal_dermal_layer0.68024784
159MP0005535_abnormal_body_temperature0.67910879
160MP0003634_abnormal_glial_cell0.67343201
161MP0008260_abnormal_autophagy0.67341371
162MP0001614_abnormal_blood_vessel0.65975858
163MP0001177_atelectasis0.65258991

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.75373826
2Deep venous thrombosis (HP:0002625)4.68741019
3Right ventricular cardiomyopathy (HP:0011663)4.01342916
4Natal tooth (HP:0000695)3.72876951
5Fragile nails (HP:0001808)3.72013598
6Abnormality of monocarboxylic acid metabolism (HP:0010996)3.64015387
7Short nail (HP:0001799)3.32046121
8Shoulder girdle muscle weakness (HP:0003547)3.17723533
9Vascular tortuosity (HP:0004948)3.15474344
10Arterial tortuosity (HP:0005116)3.09215657
11Atrophic scars (HP:0001075)3.08625781
12Trismus (HP:0000211)3.06172267
13Complement deficiency (HP:0004431)3.05849160
14Cerebral aneurysm (HP:0004944)3.04391860
15Protrusio acetabuli (HP:0003179)2.96825919
16Abnormality of aromatic amino acid family metabolism (HP:0004338)2.95914352
17Aortic dissection (HP:0002647)2.95025653
18Absent eyelashes (HP:0000561)2.93928660
19Abnormality of the aortic arch (HP:0012303)2.92868800
20Difficulty climbing stairs (HP:0003551)2.90673658
21Abnormality of complement system (HP:0005339)2.88856495
22Abnormality of the umbilical cord (HP:0010881)2.88344909
23Vertebral compression fractures (HP:0002953)2.88337503
24Bronchomalacia (HP:0002780)2.75170182
25Shallow orbits (HP:0000586)2.74710428
26Hemorrhage of the eye (HP:0011885)2.66707524
27Concave nail (HP:0001598)2.63421407
28Pelvic girdle muscle weakness (HP:0003749)2.61580511
29Advanced eruption of teeth (HP:0006288)2.58486154
30Aortic aneurysm (HP:0004942)2.56528960
31Cervical subluxation (HP:0003308)2.55345724
32Prolonged partial thromboplastin time (HP:0003645)2.54023231
33Absent eyebrow (HP:0002223)2.51527965
34Increased variability in muscle fiber diameter (HP:0003557)2.51232495
35Xanthomatosis (HP:0000991)2.49949342
36Sparse eyelashes (HP:0000653)2.48719249
37Fragile skin (HP:0001030)2.48196005
38Ulnar bowing (HP:0003031)2.45150446
39Bladder diverticulum (HP:0000015)2.44792377
40Rough bone trabeculation (HP:0100670)2.43181181
41Hypertriglyceridemia (HP:0002155)2.42340663
42Blue sclerae (HP:0000592)2.42120615
43Wormian bones (HP:0002645)2.41582808
44Abnormality of dentin (HP:0010299)2.41470155
45Onycholysis (HP:0001806)2.40835050
46Joint hemorrhage (HP:0005261)2.37611120
47Hypotrichosis (HP:0001006)2.37226769
48Choanal stenosis (HP:0000452)2.32897037
49Mitral stenosis (HP:0001718)2.31645684
50Milia (HP:0001056)2.29996409
51Abnormality of the fetal cardiovascular system (HP:0010948)2.28036229
52Abnormal umbilical cord blood vessels (HP:0011403)2.28036229
53Single umbilical artery (HP:0001195)2.28036229
54Biconcave vertebral bodies (HP:0004586)2.27762962
55Stridor (HP:0010307)2.26838085
56Mitral valve prolapse (HP:0001634)2.26589189
57Distal lower limb muscle weakness (HP:0009053)2.26355202
58Hyperlipoproteinemia (HP:0010980)2.24898639
59Abnormality of the hip-girdle musculature (HP:0001445)2.23235741
60Abnormality of the musculature of the pelvis (HP:0001469)2.23235741
61Woolly hair (HP:0002224)2.23045173
62Plantar hyperkeratosis (HP:0007556)2.22802771
63Hypercholesterolemia (HP:0003124)2.22226953
64Ankle contracture (HP:0006466)2.21969329
65Achilles tendon contracture (HP:0001771)2.21830846
66Lymphangioma (HP:0100764)2.21293009
67Obstructive sleep apnea (HP:0002870)2.19902082
68Nail dystrophy (HP:0008404)2.18038113
69Limb-girdle muscle atrophy (HP:0003797)2.17418544
70Ventricular fibrillation (HP:0001663)2.15166041
71Mildly elevated creatine phosphokinase (HP:0008180)2.13279027
72Myopathic facies (HP:0002058)2.12549349
73Hyperacusis (HP:0010780)2.10073538
74Abnormality of cells of the erythroid lineage (HP:0012130)2.08929802
75Male infertility (HP:0003251)2.08842180
76Myocardial infarction (HP:0001658)2.08571491
77Cerebral inclusion bodies (HP:0100314)2.05490901
78Abnormality of carpal bone ossification (HP:0006257)2.05160370
79Mitral regurgitation (HP:0001653)2.04694504
80Breast hypoplasia (HP:0003187)2.04322056
81Abnormality of skeletal muscle fiber size (HP:0012084)2.04191775
82Spinal rigidity (HP:0003306)2.00689449
83Soft skin (HP:0000977)2.00474478
84Selective tooth agenesis (HP:0001592)2.00325687
85Abnormality of the Achilles tendon (HP:0005109)1.97981098
86Split foot (HP:0001839)1.97672012
87Neurofibrillary tangles (HP:0002185)1.95994663
88Hypoalphalipoproteinemia (HP:0003233)1.94806202
89Systemic lupus erythematosus (HP:0002725)1.94425858
90Ileus (HP:0002595)1.94017796
91Hyperextensible skin (HP:0000974)1.94010064
92Axonal loss (HP:0003447)1.93453520
93Abnormality of nail color (HP:0100643)1.93435389
94Cardiovascular calcification (HP:0011915)1.92704795
95Facial cleft (HP:0002006)1.92148927
96Turricephaly (HP:0000262)1.91684790
97Congenital, generalized hypertrichosis (HP:0004540)1.91627503
98Growth hormone excess (HP:0000845)1.90946138
99Insulin resistance (HP:0000855)1.90862166
100Down-sloping shoulders (HP:0200021)1.90845897
101Ectopia lentis (HP:0001083)1.90099871
102Hyporeflexia of lower limbs (HP:0002600)1.89835609
103Curly hair (HP:0002212)1.88961118
104Disproportionate tall stature (HP:0001519)1.88878536
105Dilatation of the ascending aorta (HP:0005111)1.88367429
106Pterygium (HP:0001059)1.88047945
107Generalized amyotrophy (HP:0003700)1.86996591
108Distal lower limb amyotrophy (HP:0008944)1.86680468
109Premature ovarian failure (HP:0008209)1.86187537
110Infantile muscular hypotonia (HP:0008947)1.85430652
111Aneurysm (HP:0002617)1.83955445
112Absent hair (HP:0002298)1.83773061
113Coxa vara (HP:0002812)1.83689489
114Abnormal ossification of hand bones (HP:0005921)1.83610445
115Intrahepatic cholestasis (HP:0001406)1.83333843
116Upper limb amyotrophy (HP:0009129)1.82262381
117Distal upper limb amyotrophy (HP:0007149)1.82262381
118Abnormalities of placenta or umbilical cord (HP:0001194)1.82168275
119Hand muscle atrophy (HP:0009130)1.81683663
120Oligomenorrhea (HP:0000876)1.79259383
121Wrist flexion contracture (HP:0001239)1.79236761
122Pili torti (HP:0003777)1.79205859
123Short hallux (HP:0010109)1.78317207
124Mesangial abnormality (HP:0001966)1.77987938
125Broad distal phalanx of finger (HP:0009836)1.77080794
126Increased connective tissue (HP:0009025)1.76496717
127Abnormality of the distal phalanges of the toes (HP:0010182)1.76417567
128Aplasia involving bones of the extremities (HP:0009825)1.76092326
129Aplasia involving bones of the upper limbs (HP:0009823)1.76092326
130Aplasia of the phalanges of the hand (HP:0009802)1.76092326
131Aplasia/Hypoplasia of the patella (HP:0006498)1.75378399
132Asymmetry of the thorax (HP:0001555)1.75141334
133Spinal cord compression (HP:0002176)1.74175214
134Skin nodule (HP:0200036)1.73990834
135Broad metatarsal (HP:0001783)1.73950054
136Neonatal short-limb short stature (HP:0008921)1.73890873
137Esophageal varix (HP:0002040)1.73821705
138Broad face (HP:0000283)1.73764651
139Abnormality of the intrinsic pathway (HP:0010989)1.73426827
140Atrioventricular block (HP:0001678)1.73330968
141Aplasia/Hypoplasia of the hallux (HP:0008362)1.71822574
142Hypoplastic toenails (HP:0001800)1.70462489
143Alopecia of scalp (HP:0002293)1.69705092
144Vascular calcification (HP:0004934)1.69633392
145Thin bony cortex (HP:0002753)1.69514800
146Neonatal death (HP:0003811)1.68933679
147Abnormality of the acetabulum (HP:0003170)1.68878164
148Patellar aplasia (HP:0006443)1.67891470
149Stenosis of the external auditory canal (HP:0000402)1.67193301
150Ureteral duplication (HP:0000073)1.66875259
151Venous abnormality (HP:0002624)1.66401143
152Coronal craniosynostosis (HP:0004440)1.66207025
153Osteolytic defects of the phalanges of the hand (HP:0009771)1.66054230
154Osteolytic defects of the hand bones (HP:0009699)1.66054230
155Congenital malformation of the right heart (HP:0011723)1.65945561
156Double outlet right ventricle (HP:0001719)1.65945561
157Secondary amenorrhea (HP:0000869)1.65085325
158Back pain (HP:0003418)1.64851966
159Truncus arteriosus (HP:0001660)1.64554811
160Abnormal blistering of the skin (HP:0008066)1.63865385
161Lower limb amyotrophy (HP:0007210)1.63776617
162Arnold-Chiari malformation (HP:0002308)1.63753041
163Angiofibromas (HP:0010615)1.62977687
164Adenoma sebaceum (HP:0009720)1.62977687
165Ridged nail (HP:0001807)1.62959663
166Joint laxity (HP:0001388)1.62753845
167Genu recurvatum (HP:0002816)1.62279398
168Acanthosis nigricans (HP:0000956)1.62105982
169Myokymia (HP:0002411)1.61817709
170Carpal bone hypoplasia (HP:0001498)1.60636250
171Abnormal delivery (HP:0001787)1.59930405
172Areflexia of lower limbs (HP:0002522)1.59260587
173Macrocytic anemia (HP:0001972)1.59248905
174Abnormal trabecular bone morphology (HP:0100671)1.59227680

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.27142009
2BUB13.53558914
3RIPK13.40819865
4SIK13.31070484
5KDR2.94506345
6BRAF2.37215246
7MAPKAPK32.34024905
8TESK12.30945741
9EPHB22.21505097
10NTRK12.16986820
11WEE12.15213389
12LATS22.14474401
13TRIB32.10534291
14AKT32.10112429
15NME22.04460003
16NME11.92027704
17SMG11.91742491
18LIMK11.89061982
19FGFR41.87406131
20ICK1.77750240
21EEF2K1.76593227
22MARK11.73481564
23MAP2K21.71709997
24PRPF4B1.63614656
25MET1.60485164
26MAP3K31.58800663
27FER1.56704525
28LMTK21.54022115
29IRAK31.53318393
30MUSK1.51839443
31STK38L1.51615500
32ARAF1.50288689
33ACVR1B1.47311680
34MST1R1.46514009
35PAK41.42412673
36MAP2K11.40991004
37MAP3K111.40531905
38NEK11.33611306
39MINK11.27208917
40CAMKK11.22354805
41ERBB31.19760588
42KSR11.17541551
43RPS6KB21.17459945
44PIM21.15846178
45TESK21.15282011
46AURKA1.14999892
47EPHA41.13880536
48TGFBR21.13415048
49PRKD31.13024092
50RPS6KA41.11150561
51TTK1.10040067
52DYRK31.08136246
53ILK1.06836583
54BRSK11.02258559
55FGFR11.01867759
56NEK21.00775664
57ZAK1.00573778
58PRKCI0.97673565
59TIE10.97268641
60PTK20.96998350
61PDPK10.96211067
62MTOR0.94003062
63PTK2B0.93131589
64PRKG20.92623978
65BCR0.91779066
66MAP3K60.90837726
67PRKD20.90548415
68BRSK20.89936262
69MAP3K90.89036385
70TAOK20.88493488
71DYRK20.87970323
72PAK10.87865806
73PLK40.87588812
74EPHB10.85590897
75SCYL20.85305370
76LATS10.82915845
77CAMK2G0.82812902
78SRPK10.82066143
79RPS6KA20.81889048
80PAK30.81240996
81MOS0.80422619
82CDK140.79326325
83DDR20.78690114
84TGFBR10.78474759
85TAOK10.78471619
86MARK20.78462085
87TSSK60.77768493
88DAPK20.77542008
89TYRO30.77439003
90CAMK2B0.77247622
91PLK30.76532588
92ROCK10.75380586
93PDGFRA0.75176434
94CDC42BPA0.73991698
95ERN10.73731851
96DAPK30.73526334
97AURKB0.72728918
98BMX0.71757545
99PLK10.71255659
100MYLK0.70787569
101GRK50.70620795
102CDK180.67177685
103CAMK10.65961999
104MAP3K80.65863874
105LRRK20.64676325
106PKN20.64659282
107NTRK20.64587529
108CDK150.63318945
109MAP3K20.62710802
110PDGFRB0.62068170
111RET0.62031903
112PRKAA20.61277563
113DMPK0.59122255
114PAK20.58684214
115UHMK10.58321369
116PAK60.57317903
117CDK11A0.56989549
118TTN0.56526830
119KSR20.55285328
120CAMK1D0.55281454
121PTK60.53105156
122PRKD10.53006088
123NTRK30.51896996
124ABL20.49383189
125GRK10.49369371
126ROCK20.48243562
127MAP3K10.47959812
128MAPK40.47723492
129PASK0.47278304
130CAMK2D0.46878064
131PRKCG0.43779140
132GSK3A0.43670127
133RAF10.43641442
134ERBB40.43328491
135MAPK120.43107009
136PLK20.40672989
137AKT20.39714180
138STK380.38134751
139DAPK10.36398986
140MAP3K120.35892106
141NEK90.35618292
142SGK30.35102463
143SRC0.35064239
144CDK60.35046918
145MAP2K30.34276244
146MAP3K130.33963397
147MAPK130.32683267
148FGFR20.32081219

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.92811431
2Ribosome_Homo sapiens_hsa030103.42294100
3Phenylalanine metabolism_Homo sapiens_hsa003602.52193852
4RNA polymerase_Homo sapiens_hsa030202.45389362
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.45374818
6Cyanoamino acid metabolism_Homo sapiens_hsa004602.42684194
7Hippo signaling pathway_Homo sapiens_hsa043902.40585730
8PPAR signaling pathway_Homo sapiens_hsa033202.34709660
9Complement and coagulation cascades_Homo sapiens_hsa046102.19333489
10Arginine biosynthesis_Homo sapiens_hsa002202.08757245
11Hedgehog signaling pathway_Homo sapiens_hsa043402.06037439
12Histidine metabolism_Homo sapiens_hsa003401.99936989
13Basal cell carcinoma_Homo sapiens_hsa052171.99617109
14Tight junction_Homo sapiens_hsa045301.93954092
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.84607837
16Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.82395471
17Pyrimidine metabolism_Homo sapiens_hsa002401.81835788
18RNA transport_Homo sapiens_hsa030131.77928424
19Fatty acid degradation_Homo sapiens_hsa000711.77514277
20Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.75815659
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.73688051
22Bladder cancer_Homo sapiens_hsa052191.72483735
23Tyrosine metabolism_Homo sapiens_hsa003501.70271835
24Olfactory transduction_Homo sapiens_hsa047401.69838929
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.66873833
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.66483342
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.62762130
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.59412888
29Bile secretion_Homo sapiens_hsa049761.58746739
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.53082698
31Pyruvate metabolism_Homo sapiens_hsa006201.50711067
32beta-Alanine metabolism_Homo sapiens_hsa004101.48658083
33Fatty acid biosynthesis_Homo sapiens_hsa000611.46418512
34Spliceosome_Homo sapiens_hsa030401.45055853
35p53 signaling pathway_Homo sapiens_hsa041151.42563064
36Cell cycle_Homo sapiens_hsa041101.41653581
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.38351247
38Retinol metabolism_Homo sapiens_hsa008301.38249339
39DNA replication_Homo sapiens_hsa030301.37787532
40Gap junction_Homo sapiens_hsa045401.35736084
41Oocyte meiosis_Homo sapiens_hsa041141.35669870
42Prion diseases_Homo sapiens_hsa050201.35105586
43Biosynthesis of amino acids_Homo sapiens_hsa012301.33388605
44Sulfur relay system_Homo sapiens_hsa041221.32637442
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.31367994
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.30901553
47Fatty acid metabolism_Homo sapiens_hsa012121.30198938
48Melanogenesis_Homo sapiens_hsa049161.29575335
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.28219840
50Axon guidance_Homo sapiens_hsa043601.26674420
51Pentose and glucuronate interconversions_Homo sapiens_hsa000401.24900813
52Adherens junction_Homo sapiens_hsa045201.22544938
53Thyroid cancer_Homo sapiens_hsa052161.21656435
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.20322438
55Synaptic vesicle cycle_Homo sapiens_hsa047211.18892913
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18533241
57Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.16398544
58ECM-receptor interaction_Homo sapiens_hsa045121.16250895
59Fatty acid elongation_Homo sapiens_hsa000621.15574791
60AMPK signaling pathway_Homo sapiens_hsa041521.15398648
61Regulation of autophagy_Homo sapiens_hsa041401.12400755
62Glycosaminoglycan degradation_Homo sapiens_hsa005311.12338937
63Purine metabolism_Homo sapiens_hsa002301.11695683
64Proteoglycans in cancer_Homo sapiens_hsa052051.11658889
65Glycerolipid metabolism_Homo sapiens_hsa005611.11038970
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.03671351
67Carbon metabolism_Homo sapiens_hsa012001.02879710
68TGF-beta signaling pathway_Homo sapiens_hsa043501.01429397
69Wnt signaling pathway_Homo sapiens_hsa043101.01165541
70Nucleotide excision repair_Homo sapiens_hsa034201.00490175
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00320750
72GnRH signaling pathway_Homo sapiens_hsa049121.00319958
73Protein digestion and absorption_Homo sapiens_hsa049741.00188096
74Glutathione metabolism_Homo sapiens_hsa004800.99278414
75Focal adhesion_Homo sapiens_hsa045100.98884245
76Chemical carcinogenesis_Homo sapiens_hsa052040.97941991
77Dilated cardiomyopathy_Homo sapiens_hsa054140.96975093
78Rap1 signaling pathway_Homo sapiens_hsa040150.96489350
79Caffeine metabolism_Homo sapiens_hsa002320.95315404
80Glioma_Homo sapiens_hsa052140.93703787
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92802314
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90553960
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.90419629
84Huntingtons disease_Homo sapiens_hsa050160.88826269
85Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.87708785
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87238601
87Fat digestion and absorption_Homo sapiens_hsa049750.86660626
88Insulin signaling pathway_Homo sapiens_hsa049100.86512521
89Arachidonic acid metabolism_Homo sapiens_hsa005900.85992296
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85769732
91Melanoma_Homo sapiens_hsa052180.85605613
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84035299
93Vibrio cholerae infection_Homo sapiens_hsa051100.83703017
94VEGF signaling pathway_Homo sapiens_hsa043700.82873273
95Endometrial cancer_Homo sapiens_hsa052130.82367290
96Vitamin B6 metabolism_Homo sapiens_hsa007500.81978393
97Base excision repair_Homo sapiens_hsa034100.81611026
98Pentose phosphate pathway_Homo sapiens_hsa000300.80480585
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.79963204
100Small cell lung cancer_Homo sapiens_hsa052220.77914475
101Starch and sucrose metabolism_Homo sapiens_hsa005000.75649850
102MicroRNAs in cancer_Homo sapiens_hsa052060.75207009
103Cardiac muscle contraction_Homo sapiens_hsa042600.75004607
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74967310
105Glucagon signaling pathway_Homo sapiens_hsa049220.73671189
106Fructose and mannose metabolism_Homo sapiens_hsa000510.70411458
107Pancreatic secretion_Homo sapiens_hsa049720.68473259
108Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68434641
109Tryptophan metabolism_Homo sapiens_hsa003800.67647317
110Lysine degradation_Homo sapiens_hsa003100.66394588
111Folate biosynthesis_Homo sapiens_hsa007900.66252772
112Vitamin digestion and absorption_Homo sapiens_hsa049770.63297560
113Sulfur metabolism_Homo sapiens_hsa009200.62392813
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61777498
115Galactose metabolism_Homo sapiens_hsa000520.61455650
116Oxytocin signaling pathway_Homo sapiens_hsa049210.60465561
117Long-term potentiation_Homo sapiens_hsa047200.59804671
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59196265
119Insulin resistance_Homo sapiens_hsa049310.57814378
120Pathways in cancer_Homo sapiens_hsa052000.57503955
121Arginine and proline metabolism_Homo sapiens_hsa003300.57104845
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.56204288
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.55200026
124Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55188497
125HTLV-I infection_Homo sapiens_hsa051660.55159232
126Parkinsons disease_Homo sapiens_hsa050120.54610087
127PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53380590
128Mismatch repair_Homo sapiens_hsa034300.52511008
129Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52384944
130Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52203131
131Endocytosis_Homo sapiens_hsa041440.52075449
132Epstein-Barr virus infection_Homo sapiens_hsa051690.51782314
133Notch signaling pathway_Homo sapiens_hsa043300.51764901
134Estrogen signaling pathway_Homo sapiens_hsa049150.51537203
135Ras signaling pathway_Homo sapiens_hsa040140.50308721
136Gastric acid secretion_Homo sapiens_hsa049710.49656084
137Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49254169
138Other glycan degradation_Homo sapiens_hsa005110.48917698
139HIF-1 signaling pathway_Homo sapiens_hsa040660.48590487
140AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47725598
141Chronic myeloid leukemia_Homo sapiens_hsa052200.47512314
142mRNA surveillance pathway_Homo sapiens_hsa030150.46260106
143Drug metabolism - other enzymes_Homo sapiens_hsa009830.46122241
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.46028192
145Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45797440
146Dopaminergic synapse_Homo sapiens_hsa047280.45540496
147Renal cell carcinoma_Homo sapiens_hsa052110.45313948
148ErbB signaling pathway_Homo sapiens_hsa040120.45007224
149Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44889446
150Amphetamine addiction_Homo sapiens_hsa050310.44763608
151Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42979221
152Thyroid hormone synthesis_Homo sapiens_hsa049180.41921820
153Propanoate metabolism_Homo sapiens_hsa006400.41714835
154Cocaine addiction_Homo sapiens_hsa050300.41437011
155Ovarian steroidogenesis_Homo sapiens_hsa049130.41142581
156Renin secretion_Homo sapiens_hsa049240.40246501
157Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39289679
158Amoebiasis_Homo sapiens_hsa051460.39070553
159Central carbon metabolism in cancer_Homo sapiens_hsa052300.37680115

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