

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | GDP-mannose metabolic process (GO:0019673) | 8.60292107 |
| 2 | DNA deamination (GO:0045006) | 7.15033619 |
| 3 | ribosomal small subunit assembly (GO:0000028) | 6.43362491 |
| 4 | viral transcription (GO:0019083) | 6.19952387 |
| 5 | translational termination (GO:0006415) | 6.02919184 |
| 6 | maturation of SSU-rRNA (GO:0030490) | 5.85118278 |
| 7 | nucleoside transmembrane transport (GO:1901642) | 5.80019128 |
| 8 | ribosomal small subunit biogenesis (GO:0042274) | 5.77899917 |
| 9 | ribosomal large subunit biogenesis (GO:0042273) | 5.45389374 |
| 10 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 5.39012666 |
| 11 | translational elongation (GO:0006414) | 5.38079409 |
| 12 | cotranslational protein targeting to membrane (GO:0006613) | 5.29337822 |
| 13 | protein targeting to ER (GO:0045047) | 5.25706607 |
| 14 | protein localization to endoplasmic reticulum (GO:0070972) | 4.98993476 |
| 15 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.97618445 |
| 16 | nucleoside transport (GO:0015858) | 4.79175885 |
| 17 | translational initiation (GO:0006413) | 4.78664530 |
| 18 | cellular protein complex disassembly (GO:0043624) | 4.71518948 |
| 19 | viral life cycle (GO:0019058) | 4.69254425 |
| 20 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 4.63769847 |
| 21 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 4.63769847 |
| 22 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.63467770 |
| 23 | proteasome assembly (GO:0043248) | 4.59225489 |
| 24 | ribonucleoprotein complex biogenesis (GO:0022613) | 4.44033598 |
| 25 | translation (GO:0006412) | 4.38357980 |
| 26 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.29946917 |
| 27 | mannose metabolic process (GO:0006013) | 4.29940004 |
| 28 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.22596289 |
| 29 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 4.21695117 |
| 30 | protein complex disassembly (GO:0043241) | 4.15492461 |
| 31 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.13661993 |
| 32 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.08917617 |
| 33 | termination of RNA polymerase III transcription (GO:0006386) | 4.08917617 |
| 34 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 4.01189897 |
| 35 | macromolecular complex disassembly (GO:0032984) | 4.00030183 |
| 36 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.95614733 |
| 37 | ATP synthesis coupled proton transport (GO:0015986) | 3.95614733 |
| 38 | cellular component biogenesis (GO:0044085) | 3.95504991 |
| 39 | DNA strand elongation (GO:0022616) | 3.93823985 |
| 40 | spliceosomal snRNP assembly (GO:0000387) | 3.93085915 |
| 41 | regulation of mitochondrial translation (GO:0070129) | 3.92284419 |
| 42 | pseudouridine synthesis (GO:0001522) | 3.91069459 |
| 43 | rRNA processing (GO:0006364) | 3.89319071 |
| 44 | rRNA modification (GO:0000154) | 3.86372098 |
| 45 | rRNA metabolic process (GO:0016072) | 3.79057661 |
| 46 | nucleobase biosynthetic process (GO:0046112) | 3.77797936 |
| 47 | peroxisome fission (GO:0016559) | 3.77375955 |
| 48 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.74340594 |
| 49 | oxidative phosphorylation (GO:0006119) | 3.71816727 |
| 50 | GTP biosynthetic process (GO:0006183) | 3.70548399 |
| 51 | purine nucleobase biosynthetic process (GO:0009113) | 3.66961359 |
| 52 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.65582990 |
| 53 | NADH dehydrogenase complex assembly (GO:0010257) | 3.65582990 |
| 54 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.65582990 |
| 55 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.64898075 |
| 56 | DNA replication initiation (GO:0006270) | 3.64634666 |
| 57 | telomere maintenance via recombination (GO:0000722) | 3.61939574 |
| 58 | ribosome biogenesis (GO:0042254) | 3.61427903 |
| 59 | DNA replication checkpoint (GO:0000076) | 3.60229561 |
| 60 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.59080219 |
| 61 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 3.58347383 |
| 62 | deoxyribose phosphate biosynthetic process (GO:0046385) | 3.58347383 |
| 63 | spliceosomal complex assembly (GO:0000245) | 3.56940957 |
| 64 | ubiquinone biosynthetic process (GO:0006744) | 3.56824833 |
| 65 | formation of translation preinitiation complex (GO:0001731) | 3.56611503 |
| 66 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.53916980 |
| 67 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.53323508 |
| 68 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.50799467 |
| 69 | protein complex biogenesis (GO:0070271) | 3.49772340 |
| 70 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.46842301 |
| 71 | UTP biosynthetic process (GO:0006228) | 3.46505208 |
| 72 | chromatin remodeling at centromere (GO:0031055) | 3.46343711 |
| 73 | short-chain fatty acid metabolic process (GO:0046459) | 3.45720499 |
| 74 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.43556022 |
| 75 | protein deneddylation (GO:0000338) | 3.43429624 |
| 76 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.42841862 |
| 77 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.41769383 |
| 78 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.41294876 |
| 79 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.41146918 |
| 80 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.40595258 |
| 81 | CENP-A containing nucleosome assembly (GO:0034080) | 3.40583052 |
| 82 | negative regulation of ligase activity (GO:0051352) | 3.40363621 |
| 83 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.40363621 |
| 84 | mRNA catabolic process (GO:0006402) | 3.38137257 |
| 85 | 7-methylguanosine mRNA capping (GO:0006370) | 3.37973299 |
| 86 | respiratory electron transport chain (GO:0022904) | 3.37865517 |
| 87 | protein targeting to membrane (GO:0006612) | 3.37496504 |
| 88 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.34535141 |
| 89 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.33921795 |
| 90 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.32473830 |
| 91 | 7-methylguanosine RNA capping (GO:0009452) | 3.30688171 |
| 92 | RNA capping (GO:0036260) | 3.30688171 |
| 93 | electron transport chain (GO:0022900) | 3.30495416 |
| 94 | protein targeting to mitochondrion (GO:0006626) | 3.26901033 |
| 95 | telomere maintenance via telomere lengthening (GO:0010833) | 3.25856047 |
| 96 | RNA catabolic process (GO:0006401) | 3.25309285 |
| 97 | GMP metabolic process (GO:0046037) | 3.24675817 |
| 98 | chaperone-mediated protein transport (GO:0072321) | 3.24270906 |
| 99 | nucleotide-sugar biosynthetic process (GO:0009226) | 3.24230969 |
| 100 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.23996335 |
| 101 | mitotic recombination (GO:0006312) | 3.23245199 |
| 102 | nucleobase-containing small molecule interconversion (GO:0015949) | 3.19497208 |
| 103 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 3.19177250 |
| 104 | deoxyribonucleotide catabolic process (GO:0009264) | 3.18776135 |
| 105 | establishment of integrated proviral latency (GO:0075713) | 3.18276299 |
| 106 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.18130294 |
| 107 | establishment of protein localization to mitochondrion (GO:0072655) | 3.17726452 |
| 108 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.17252192 |
| 109 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.17223410 |
| 110 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.17223410 |
| 111 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.17131731 |
| 112 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.17131731 |
| 113 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.17131731 |
| 114 | purine deoxyribonucleoside triphosphate metabolic process (GO:0009215) | 3.16613087 |
| 115 | regulation of dopamine uptake involved in synaptic transmission (GO:0051584) | 3.16219002 |
| 116 | regulation of catecholamine uptake involved in synaptic transmission (GO:0051940) | 3.16219002 |
| 117 | base-excision repair, AP site formation (GO:0006285) | 3.15268655 |
| 118 | kinetochore assembly (GO:0051382) | 3.15204512 |
| 119 | ubiquinone metabolic process (GO:0006743) | 3.13638345 |
| 120 | regulation of penile erection (GO:0060405) | 3.13534884 |
| 121 | iron-sulfur cluster assembly (GO:0016226) | 3.13405511 |
| 122 | metallo-sulfur cluster assembly (GO:0031163) | 3.13405511 |
| 123 | aerobic respiration (GO:0009060) | 3.13332189 |
| 124 | viral mRNA export from host cell nucleus (GO:0046784) | 3.12497201 |
| 125 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.11759071 |
| 126 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.11759071 |
| 127 | pteridine-containing compound biosynthetic process (GO:0042559) | 3.10423778 |
| 128 | nucleotide salvage (GO:0043173) | 3.06585327 |
| 129 | intracellular protein transmembrane import (GO:0044743) | 3.03388068 |
| 130 | regulation of mitochondrial membrane potential (GO:0051881) | 3.02585087 |
| 131 | regulation of proton transport (GO:0010155) | 3.02524887 |
| 132 | protein localization to mitochondrion (GO:0070585) | 3.01218071 |
| 133 | deoxyribose phosphate catabolic process (GO:0046386) | 2.99278542 |
| 134 | cytidine deamination (GO:0009972) | 2.98748961 |
| 135 | cytidine metabolic process (GO:0046087) | 2.98748961 |
| 136 | cytidine catabolic process (GO:0006216) | 2.98748961 |
| 137 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 2.97394968 |
| 138 | protein neddylation (GO:0045116) | 2.95298741 |
| 139 | 2-deoxyribonucleotide metabolic process (GO:0009394) | 2.94455757 |
| 140 | pyrimidine-containing compound salvage (GO:0008655) | 2.93923492 |
| 141 | pyrimidine nucleoside salvage (GO:0043097) | 2.93923492 |
| 142 | rRNA methylation (GO:0031167) | 2.91126670 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 5.10171409 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.57785368 |
| 3 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.32208331 |
| 4 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 4.00176943 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.85906145 |
| 6 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.75491560 |
| 7 | * EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.66020096 |
| 8 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.53816893 |
| 9 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.30365364 |
| 10 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.24594624 |
| 11 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.23556299 |
| 12 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.19605243 |
| 13 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.11960077 |
| 14 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.97413864 |
| 15 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.93353825 |
| 16 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.86867605 |
| 17 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.68573610 |
| 18 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.63965710 |
| 19 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.63757625 |
| 20 | * E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.60332859 |
| 21 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.59881040 |
| 22 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.55375185 |
| 23 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.50924058 |
| 24 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.44205954 |
| 25 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.38940593 |
| 26 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.38341060 |
| 27 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.32521615 |
| 28 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.25941561 |
| 29 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.20301737 |
| 30 | * NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.19860040 |
| 31 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.17149570 |
| 32 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.12103923 |
| 33 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.11558492 |
| 34 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.08387901 |
| 35 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.89580607 |
| 36 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.89310899 |
| 37 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.88798552 |
| 38 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.79065317 |
| 39 | * TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.78585636 |
| 40 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.77734008 |
| 41 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.75743254 |
| 42 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.67886428 |
| 43 | * FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.66637790 |
| 44 | * CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.64995158 |
| 45 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.62166322 |
| 46 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.61958492 |
| 47 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.60005773 |
| 48 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.59827284 |
| 49 | * HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.58758326 |
| 50 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.58290352 |
| 51 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.57496140 |
| 52 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.50011443 |
| 53 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.47906892 |
| 54 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.46447258 |
| 55 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.45867884 |
| 56 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.45363584 |
| 57 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.45018854 |
| 58 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.42777444 |
| 59 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.40639102 |
| 60 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.38791867 |
| 61 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.37130063 |
| 62 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.33939489 |
| 63 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.33459228 |
| 64 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.32971250 |
| 65 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.32819727 |
| 66 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.31280654 |
| 67 | P68_20966046_ChIP-Seq_HELA_Human | 1.30643243 |
| 68 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.29701610 |
| 69 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.28051051 |
| 70 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.25908641 |
| 71 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.25844791 |
| 72 | * BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.22048364 |
| 73 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.21497399 |
| 74 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.20701955 |
| 75 | * KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.18546339 |
| 76 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.17743169 |
| 77 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.15923344 |
| 78 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.15136653 |
| 79 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.14769537 |
| 80 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.11701359 |
| 81 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.10852373 |
| 82 | E2F1_20622854_ChIP-Seq_HELA_Human | 1.10795374 |
| 83 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.10478715 |
| 84 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.08722814 |
| 85 | * DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.07240303 |
| 86 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.06852774 |
| 87 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.02138457 |
| 88 | PHF8_20622854_ChIP-Seq_HELA_Human | 1.01530392 |
| 89 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 1.01471886 |
| 90 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.01138856 |
| 91 | CTCF_21964334_Chip-Seq_Bcells_Human | 0.99871915 |
| 92 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 0.99503098 |
| 93 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.99492379 |
| 94 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.99189872 |
| 95 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.97970883 |
| 96 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.97678390 |
| 97 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.96919127 |
| 98 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.96898488 |
| 99 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.94289874 |
| 100 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.93658139 |
| 101 | * SA1_27219007_Chip-Seq_Bcells_Human | 0.93473703 |
| 102 | * SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.93090625 |
| 103 | * MAF_26560356_Chip-Seq_TH2_Human | 0.91956044 |
| 104 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.91393554 |
| 105 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.90877162 |
| 106 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.90297719 |
| 107 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.90012411 |
| 108 | CTCF_20526341_ChIP-Seq_ESCs_Human | 0.89809752 |
| 109 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.88401436 |
| 110 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.87839629 |
| 111 | * BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.87015888 |
| 112 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.86724766 |
| 113 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 0.85764669 |
| 114 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.84789892 |
| 115 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.84562831 |
| 116 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.83892110 |
| 117 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.83733628 |
| 118 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.82907786 |
| 119 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.82550773 |
| 120 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.81080375 |
| 121 | * TFEB_21752829_ChIP-Seq_HELA_Human | 0.80967888 |
| 122 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.79605081 |
| 123 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.76892779 |
| 124 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.76689843 |
| 125 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.74908979 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.66608127 |
| 2 | MP0009379_abnormal_foot_pigmentation | 4.33017420 |
| 3 | MP0004957_abnormal_blastocyst_morpholog | 4.15431852 |
| 4 | MP0003111_abnormal_nucleus_morphology | 3.66995916 |
| 5 | MP0010094_abnormal_chromosome_stability | 3.59200068 |
| 6 | MP0003077_abnormal_cell_cycle | 3.36424899 |
| 7 | MP0008058_abnormal_DNA_repair | 3.23294904 |
| 8 | MP0001727_abnormal_embryo_implantation | 3.10557203 |
| 9 | MP0003806_abnormal_nucleotide_metabolis | 3.10013053 |
| 10 | MP0002822_catalepsy | 3.07593145 |
| 11 | MP0003186_abnormal_redox_activity | 2.96699530 |
| 12 | MP0008260_abnormal_autophagy | 2.89271319 |
| 13 | MP0008932_abnormal_embryonic_tissue | 2.71123682 |
| 14 | MP0008007_abnormal_cellular_replicative | 2.46596780 |
| 15 | MP0008057_abnormal_DNA_replication | 2.42472606 |
| 16 | MP0003878_abnormal_ear_physiology | 2.40344189 |
| 17 | MP0005377_hearing/vestibular/ear_phenot | 2.40344189 |
| 18 | MP0006036_abnormal_mitochondrial_physio | 2.34118807 |
| 19 | MP0002132_abnormal_respiratory_system | 2.33392048 |
| 20 | MP0003718_maternal_effect | 2.24505804 |
| 21 | MP0006292_abnormal_olfactory_placode | 2.23240358 |
| 22 | MP0005671_abnormal_response_to | 2.18275811 |
| 23 | MP0003786_premature_aging | 2.09252512 |
| 24 | MP0002396_abnormal_hematopoietic_system | 1.81015069 |
| 25 | MP0000490_abnormal_crypts_of | 1.79345283 |
| 26 | MP0005075_abnormal_melanosome_morpholog | 1.75433233 |
| 27 | MP0001485_abnormal_pinna_reflex | 1.74386723 |
| 28 | MP0006035_abnormal_mitochondrial_morpho | 1.73205780 |
| 29 | MP0005423_abnormal_somatic_nervous | 1.68930800 |
| 30 | MP0001986_abnormal_taste_sensitivity | 1.67887026 |
| 31 | MP0001764_abnormal_homeostasis | 1.63785291 |
| 32 | MP0010030_abnormal_orbit_morphology | 1.61103788 |
| 33 | MP0003315_abnormal_perineum_morphology | 1.60701984 |
| 34 | MP0008789_abnormal_olfactory_epithelium | 1.60562093 |
| 35 | MP0001529_abnormal_vocalization | 1.53230927 |
| 36 | MP0004133_heterotaxia | 1.52759020 |
| 37 | MP0002837_dystrophic_cardiac_calcinosis | 1.50447897 |
| 38 | MP0001730_embryonic_growth_arrest | 1.44506879 |
| 39 | MP0003123_paternal_imprinting | 1.44324207 |
| 40 | MP0000350_abnormal_cell_proliferation | 1.40197068 |
| 41 | MP0003656_abnormal_erythrocyte_physiolo | 1.33917212 |
| 42 | MP0001881_abnormal_mammary_gland | 1.33352351 |
| 43 | MP0004147_increased_porphyrin_level | 1.33020756 |
| 44 | MP0002160_abnormal_reproductive_system | 1.31508627 |
| 45 | MP0000313_abnormal_cell_death | 1.29161919 |
| 46 | MP0000358_abnormal_cell_content/ | 1.27684093 |
| 47 | MP0009333_abnormal_splenocyte_physiolog | 1.26452125 |
| 48 | MP0002234_abnormal_pharynx_morphology | 1.24078609 |
| 49 | MP0005389_reproductive_system_phenotype | 1.19433236 |
| 50 | MP0001542_abnormal_bone_strength | 1.18344198 |
| 51 | MP0002277_abnormal_respiratory_mucosa | 1.16496173 |
| 52 | MP0005501_abnormal_skin_physiology | 1.15305644 |
| 53 | MP0000750_abnormal_muscle_regeneration | 1.14337942 |
| 54 | MP0002638_abnormal_pupillary_reflex | 1.13065037 |
| 55 | MP0002653_abnormal_ependyma_morphology | 1.11475888 |
| 56 | MP0002019_abnormal_tumor_incidence | 1.09794841 |
| 57 | MP0006072_abnormal_retinal_apoptosis | 1.09739400 |
| 58 | MP0002080_prenatal_lethality | 1.07243334 |
| 59 | MP0001697_abnormal_embryo_size | 1.06816021 |
| 60 | MP0002210_abnormal_sex_determination | 1.05461929 |
| 61 | MP0005174_abnormal_tail_pigmentation | 1.02854649 |
| 62 | MP0000372_irregular_coat_pigmentation | 1.02696394 |
| 63 | MP0000049_abnormal_middle_ear | 1.01240108 |
| 64 | MP0005636_abnormal_mineral_homeostasis | 1.01033834 |
| 65 | MP0005499_abnormal_olfactory_system | 0.98932670 |
| 66 | MP0005394_taste/olfaction_phenotype | 0.98932670 |
| 67 | MP0001919_abnormal_reproductive_system | 0.98308975 |
| 68 | MP0002163_abnormal_gland_morphology | 0.97967284 |
| 69 | MP0000462_abnormal_digestive_system | 0.97295916 |
| 70 | MP0002102_abnormal_ear_morphology | 0.96785192 |
| 71 | MP0009697_abnormal_copulation | 0.95947824 |
| 72 | MP0000678_abnormal_parathyroid_gland | 0.94849663 |
| 73 | MP0005646_abnormal_pituitary_gland | 0.94613648 |
| 74 | MP0001672_abnormal_embryogenesis/_devel | 0.94070501 |
| 75 | MP0005380_embryogenesis_phenotype | 0.94070501 |
| 76 | MP0000566_synostosis | 0.93840566 |
| 77 | MP0008877_abnormal_DNA_methylation | 0.93402735 |
| 78 | MP0002249_abnormal_larynx_morphology | 0.92645860 |
| 79 | MP0003136_yellow_coat_color | 0.92571401 |
| 80 | MP0000026_abnormal_inner_ear | 0.91991093 |
| 81 | MP0003763_abnormal_thymus_physiology | 0.91909249 |
| 82 | MP0003646_muscle_fatigue | 0.91640774 |
| 83 | MP0005332_abnormal_amino_acid | 0.91451597 |
| 84 | MP0003011_delayed_dark_adaptation | 0.90845409 |
| 85 | MP0001145_abnormal_male_reproductive | 0.90767813 |
| 86 | MP0004858_abnormal_nervous_system | 0.90439407 |
| 87 | MP0000579_abnormal_nail_morphology | 0.90082700 |
| 88 | MP0005266_abnormal_metabolism | 0.88536743 |
| 89 | MP0005397_hematopoietic_system_phenotyp | 0.87475262 |
| 90 | MP0001545_abnormal_hematopoietic_system | 0.87475262 |
| 91 | MP0008995_early_reproductive_senescence | 0.85821707 |
| 92 | MP0002095_abnormal_skin_pigmentation | 0.84209826 |
| 93 | MP0005220_abnormal_exocrine_pancreas | 0.83065015 |
| 94 | MP0002085_abnormal_embryonic_tissue | 0.82998557 |
| 95 | MP0005084_abnormal_gallbladder_morpholo | 0.82276711 |
| 96 | MP0001929_abnormal_gametogenesis | 0.82203156 |
| 97 | MP0002751_abnormal_autonomic_nervous | 0.81846221 |
| 98 | MP0001873_stomach_inflammation | 0.80990398 |
| 99 | MP0002938_white_spotting | 0.79613925 |
| 100 | MP0000653_abnormal_sex_gland | 0.79045998 |
| 101 | MP0003119_abnormal_digestive_system | 0.77396085 |
| 102 | MP0001661_extended_life_span | 0.77027464 |
| 103 | MP0001293_anophthalmia | 0.76803994 |
| 104 | MP0003984_embryonic_growth_retardation | 0.76594475 |
| 105 | MP0000747_muscle_weakness | 0.76180347 |
| 106 | MP0005379_endocrine/exocrine_gland_phen | 0.75518321 |
| 107 | MP0002139_abnormal_hepatobiliary_system | 0.75226855 |
| 108 | MP0005085_abnormal_gallbladder_physiolo | 0.75164779 |
| 109 | MP0002088_abnormal_embryonic_growth/wei | 0.73795509 |
| 110 | MP0005408_hypopigmentation | 0.73401677 |
| 111 | MP0001119_abnormal_female_reproductive | 0.72541964 |
| 112 | MP0009765_abnormal_xenobiotic_induced | 0.71393574 |
| 113 | MP0008873_increased_physiological_sensi | 0.71211332 |
| 114 | MP0004043_abnormal_pH_regulation | 0.71199926 |
| 115 | MP0001853_heart_inflammation | 0.70834384 |
| 116 | MP0005083_abnormal_biliary_tract | 0.70025963 |
| 117 | MP0005376_homeostasis/metabolism_phenot | 0.69742218 |
| 118 | MP0001188_hyperpigmentation | 0.68925138 |
| 119 | MP0000015_abnormal_ear_pigmentation | 0.68177258 |
| 120 | MP0004145_abnormal_muscle_electrophysio | 0.68015170 |
| 121 | MP0003890_abnormal_embryonic-extraembry | 0.67847350 |
| 122 | MP0005195_abnormal_posterior_eye | 0.66117241 |
| 123 | MP0003567_abnormal_fetal_cardiomyocyte | 0.66045530 |
| 124 | MP0002971_abnormal_brown_adipose | 0.65483909 |
| 125 | MP0002722_abnormal_immune_system | 0.65290283 |
| 126 | MP0005360_urolithiasis | 0.64555944 |
| 127 | MP0003698_abnormal_male_reproductive | 0.64464436 |
| 128 | MP0000689_abnormal_spleen_morphology | 0.64048090 |
| 129 | MP0004381_abnormal_hair_follicle | 0.63870210 |
| 130 | MP0000343_altered_response_to | 0.63327285 |
| 131 | MP0003938_abnormal_ear_development | 0.62874080 |
| 132 | MP0001944_abnormal_pancreas_morphology | 0.62383784 |
| 133 | MP0004885_abnormal_endolymph | 0.62075456 |
| 134 | MP0005645_abnormal_hypothalamus_physiol | 0.61849755 |
| 135 | MP0008872_abnormal_physiological_respon | 0.61507563 |
| 136 | MP0003936_abnormal_reproductive_system | 0.60860158 |
| 137 | MP0000703_abnormal_thymus_morphology | 0.60460638 |
| 138 | MP0005410_abnormal_fertilization | 0.60115553 |
| 139 | MP0005319_abnormal_enzyme/_coenzyme | 0.59245522 |
| 140 | MP0001905_abnormal_dopamine_level | 0.58924818 |
| 141 | MP0002177_abnormal_outer_ear | 0.57719315 |
| 142 | MP0003879_abnormal_hair_cell | 0.56655845 |
| 143 | MP0009840_abnormal_foam_cell | 0.55959452 |
| 144 | MP0002752_abnormal_somatic_nervous | 0.55759397 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of cells of the erythroid lineage (HP:0012130) | 6.10012024 |
| 2 | Abnormal number of erythroid precursors (HP:0012131) | 5.73096863 |
| 3 | Reticulocytopenia (HP:0001896) | 5.21721899 |
| 4 | Acute necrotizing encephalopathy (HP:0006965) | 4.90484130 |
| 5 | Mitochondrial inheritance (HP:0001427) | 4.86361961 |
| 6 | Hepatocellular necrosis (HP:0001404) | 4.75706539 |
| 7 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.53547406 |
| 8 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 4.52680751 |
| 9 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 4.52680751 |
| 10 | Hepatic necrosis (HP:0002605) | 4.47491856 |
| 11 | Macrocytic anemia (HP:0001972) | 4.47350410 |
| 12 | Increased CSF lactate (HP:0002490) | 4.37477131 |
| 13 | Acute encephalopathy (HP:0006846) | 4.22041532 |
| 14 | Increased hepatocellular lipid droplets (HP:0006565) | 4.12032618 |
| 15 | Global brain atrophy (HP:0002283) | 4.08600382 |
| 16 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 4.02379886 |
| 17 | Progressive macrocephaly (HP:0004481) | 3.84210271 |
| 18 | Hyperglycinemia (HP:0002154) | 3.79894585 |
| 19 | Lipid accumulation in hepatocytes (HP:0006561) | 3.77925397 |
| 20 | Increased serum lactate (HP:0002151) | 3.77754563 |
| 21 | Pallor (HP:0000980) | 3.76953122 |
| 22 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 3.73151550 |
| 23 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.65723524 |
| 24 | Akinesia (HP:0002304) | 3.63110342 |
| 25 | 3-Methylglutaconic aciduria (HP:0003535) | 3.62036937 |
| 26 | Patent foramen ovale (HP:0001655) | 3.58414162 |
| 27 | Oral leukoplakia (HP:0002745) | 3.45858988 |
| 28 | Increased intramyocellular lipid droplets (HP:0012240) | 3.37618351 |
| 29 | Renal Fanconi syndrome (HP:0001994) | 3.31265420 |
| 30 | Breast hypoplasia (HP:0003187) | 3.29559933 |
| 31 | Lactic acidosis (HP:0003128) | 3.28173585 |
| 32 | Exertional dyspnea (HP:0002875) | 3.19783353 |
| 33 | Birth length less than 3rd percentile (HP:0003561) | 3.19534391 |
| 34 | Cerebral edema (HP:0002181) | 3.17487009 |
| 35 | Exercise intolerance (HP:0003546) | 3.09889945 |
| 36 | Broad distal phalanx of finger (HP:0009836) | 3.09829426 |
| 37 | Respiratory failure (HP:0002878) | 3.05270854 |
| 38 | Aplastic anemia (HP:0001915) | 3.02482593 |
| 39 | Increased muscle lipid content (HP:0009058) | 2.94648014 |
| 40 | Ragged-red muscle fibers (HP:0003200) | 2.88809515 |
| 41 | Neurodegeneration (HP:0002180) | 2.88317218 |
| 42 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 2.83091968 |
| 43 | Cerebral hypomyelination (HP:0006808) | 2.81790878 |
| 44 | Rough bone trabeculation (HP:0100670) | 2.77589758 |
| 45 | Diminished movement (HP:0002374) | 2.76326818 |
| 46 | Dysphonia (HP:0001618) | 2.70883955 |
| 47 | Carpal bone hypoplasia (HP:0001498) | 2.69958873 |
| 48 | Respiratory difficulties (HP:0002880) | 2.63728880 |
| 49 | Absent thumb (HP:0009777) | 2.63153231 |
| 50 | Hypobetalipoproteinemia (HP:0003563) | 2.60333736 |
| 51 | Testicular atrophy (HP:0000029) | 2.60079547 |
| 52 | Type I transferrin isoform profile (HP:0003642) | 2.54628669 |
| 53 | Microvesicular hepatic steatosis (HP:0001414) | 2.50567872 |
| 54 | Dyskinesia (HP:0100660) | 2.49868196 |
| 55 | CNS demyelination (HP:0007305) | 2.49031594 |
| 56 | 11 pairs of ribs (HP:0000878) | 2.48235441 |
| 57 | Increased serum pyruvate (HP:0003542) | 2.43668495 |
| 58 | Abnormality of glycolysis (HP:0004366) | 2.43668495 |
| 59 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.42844444 |
| 60 | Lethargy (HP:0001254) | 2.35122731 |
| 61 | Methylmalonic acidemia (HP:0002912) | 2.34953879 |
| 62 | Tubulointerstitial nephritis (HP:0001970) | 2.33972333 |
| 63 | Abnormality of pyrimidine metabolism (HP:0004353) | 2.33614239 |
| 64 | Abnormality of the preputium (HP:0100587) | 2.32290811 |
| 65 | Poor suck (HP:0002033) | 2.29943363 |
| 66 | Pancytopenia (HP:0001876) | 2.29145174 |
| 67 | Progressive microcephaly (HP:0000253) | 2.28895791 |
| 68 | Opisthotonus (HP:0002179) | 2.28571957 |
| 69 | Fetal akinesia sequence (HP:0001989) | 2.27923508 |
| 70 | Trismus (HP:0000211) | 2.27660036 |
| 71 | Delayed CNS myelination (HP:0002188) | 2.26047536 |
| 72 | Triphalangeal thumb (HP:0001199) | 2.25891850 |
| 73 | Degeneration of anterior horn cells (HP:0002398) | 2.24485248 |
| 74 | Abnormality of the anterior horn cell (HP:0006802) | 2.24485248 |
| 75 | Abnormal hemoglobin (HP:0011902) | 2.23571682 |
| 76 | Optic disc pallor (HP:0000543) | 2.22430498 |
| 77 | Emotional lability (HP:0000712) | 2.22116172 |
| 78 | Microretrognathia (HP:0000308) | 2.20356406 |
| 79 | Progressive muscle weakness (HP:0003323) | 2.20231605 |
| 80 | Secondary amenorrhea (HP:0000869) | 2.19393145 |
| 81 | Horseshoe kidney (HP:0000085) | 2.18747076 |
| 82 | Renal tubular dysfunction (HP:0000124) | 2.17486753 |
| 83 | Abnormality of fatty-acid metabolism (HP:0004359) | 2.16821635 |
| 84 | Leukodystrophy (HP:0002415) | 2.14680546 |
| 85 | Abnormality of urine glucose concentration (HP:0011016) | 2.14434950 |
| 86 | Glycosuria (HP:0003076) | 2.14434950 |
| 87 | Abnormality of renal resorption (HP:0011038) | 2.13722252 |
| 88 | Methylmalonic aciduria (HP:0012120) | 2.13385899 |
| 89 | Patellar aplasia (HP:0006443) | 2.11561649 |
| 90 | Multiple enchondromatosis (HP:0005701) | 2.10546999 |
| 91 | Colon cancer (HP:0003003) | 2.10534169 |
| 92 | Brushfield spots (HP:0001088) | 2.10152934 |
| 93 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.10028086 |
| 94 | Abnormality of glycine metabolism (HP:0010895) | 2.10028086 |
| 95 | Meckel diverticulum (HP:0002245) | 2.09806715 |
| 96 | Abnormal trabecular bone morphology (HP:0100671) | 2.08579689 |
| 97 | Hyperphosphaturia (HP:0003109) | 2.08186021 |
| 98 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.07443658 |
| 99 | Abnormality of reticulocytes (HP:0004312) | 2.06525906 |
| 100 | Abnormality of the phalanges of the 2nd finger (HP:0009541) | 2.03627190 |
| 101 | Abnormality of serum amino acid levels (HP:0003112) | 2.02503346 |
| 102 | Nausea (HP:0002018) | 2.01296138 |
| 103 | Abnormality of the ileum (HP:0001549) | 1.98259049 |
| 104 | Megaloblastic anemia (HP:0001889) | 1.96971525 |
| 105 | Abnormality of the phalanges of the hallux (HP:0010057) | 1.95510893 |
| 106 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 1.95503993 |
| 107 | Hyperammonemia (HP:0001987) | 1.95476284 |
| 108 | Premature graying of hair (HP:0002216) | 1.93028042 |
| 109 | Death in infancy (HP:0001522) | 1.92610028 |
| 110 | Sparse eyelashes (HP:0000653) | 1.92268137 |
| 111 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.91691389 |
| 112 | Abnormality of alanine metabolism (HP:0010916) | 1.91691389 |
| 113 | Hyperalaninemia (HP:0003348) | 1.91691389 |
| 114 | Abnormal glycosylation (HP:0012345) | 1.90661945 |
| 115 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.90661945 |
| 116 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.90661945 |
| 117 | Abnormal protein glycosylation (HP:0012346) | 1.90661945 |
| 118 | Spastic paraparesis (HP:0002313) | 1.89612327 |
| 119 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.89248500 |
| 120 | Dicarboxylic aciduria (HP:0003215) | 1.89248500 |
| 121 | Hypoplasia of the radius (HP:0002984) | 1.89135305 |
| 122 | Generalized aminoaciduria (HP:0002909) | 1.88373590 |
| 123 | Gliosis (HP:0002171) | 1.86870344 |
| 124 | Fibular aplasia (HP:0002990) | 1.85841687 |
| 125 | Acanthocytosis (HP:0001927) | 1.84659473 |
| 126 | Cerebral palsy (HP:0100021) | 1.81690344 |
| 127 | Abnormality of chromosome stability (HP:0003220) | 1.81225063 |
| 128 | Tongue fasciculations (HP:0001308) | 1.79750091 |
| 129 | Bone marrow hypocellularity (HP:0005528) | 1.78928837 |
| 130 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.78830632 |
| 131 | Muscle fiber atrophy (HP:0100295) | 1.76696105 |
| 132 | Cleft eyelid (HP:0000625) | 1.75119117 |
| 133 | Poor head control (HP:0002421) | 1.74272565 |
| 134 | Cellular immunodeficiency (HP:0005374) | 1.74126605 |
| 135 | Congenital stationary night blindness (HP:0007642) | 1.73627891 |
| 136 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.72684040 |
| 137 | Premature ovarian failure (HP:0008209) | 1.72647328 |
| 138 | Type 2 muscle fiber atrophy (HP:0003554) | 1.71606957 |
| 139 | Short tibia (HP:0005736) | 1.71137688 |
| 140 | Reduced antithrombin III activity (HP:0001976) | 1.70181804 |
| 141 | Severe muscular hypotonia (HP:0006829) | 1.68101864 |
| 142 | Paralysis (HP:0003470) | 1.67486779 |
| 143 | Gait imbalance (HP:0002141) | 1.65364517 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.97660389 |
| 2 | TLK1 | 4.02540205 |
| 3 | NME2 | 3.95038228 |
| 4 | STK16 | 3.79389397 |
| 5 | PRPF4B | 3.73311062 |
| 6 | WEE1 | 3.60458852 |
| 7 | EIF2AK1 | 3.53323861 |
| 8 | VRK2 | 3.28074281 |
| 9 | SRPK1 | 2.89243646 |
| 10 | VRK1 | 2.68839843 |
| 11 | BCKDK | 2.35085993 |
| 12 | ERN1 | 2.33210307 |
| 13 | CDC7 | 2.24521219 |
| 14 | EIF2AK3 | 2.10472880 |
| 15 | DYRK3 | 2.08976048 |
| 16 | TESK2 | 2.04577489 |
| 17 | NME1 | 2.01202287 |
| 18 | BRSK2 | 1.82615933 |
| 19 | MAP3K11 | 1.82509027 |
| 20 | ACVR1B | 1.77972763 |
| 21 | PLK4 | 1.77702370 |
| 22 | PIM2 | 1.77313443 |
| 23 | PBK | 1.60761626 |
| 24 | PLK1 | 1.45118607 |
| 25 | AURKA | 1.44826946 |
| 26 | MKNK1 | 1.37770503 |
| 27 | PDK2 | 1.37399947 |
| 28 | BRAF | 1.37351497 |
| 29 | NEK2 | 1.34160755 |
| 30 | PRKD3 | 1.32316986 |
| 31 | MAP4K2 | 1.30401168 |
| 32 | CDK8 | 1.29241183 |
| 33 | AURKB | 1.28287547 |
| 34 | TSSK6 | 1.28171277 |
| 35 | TTK | 1.26512605 |
| 36 | RPS6KA4 | 1.24909247 |
| 37 | CDK19 | 1.23787399 |
| 38 | ZAK | 1.23238366 |
| 39 | CDK7 | 1.21665061 |
| 40 | FLT3 | 1.19047911 |
| 41 | KDR | 1.14842271 |
| 42 | MKNK2 | 1.12433424 |
| 43 | BRSK1 | 1.10965640 |
| 44 | CCNB1 | 1.08037444 |
| 45 | IRAK3 | 1.06371704 |
| 46 | TRIM28 | 1.05628525 |
| 47 | RPS6KB2 | 1.02791221 |
| 48 | ABL2 | 0.98579910 |
| 49 | ATR | 0.98389515 |
| 50 | MAP2K7 | 0.97705739 |
| 51 | PRKD2 | 0.97091214 |
| 52 | DYRK2 | 0.90061597 |
| 53 | DAPK1 | 0.89112648 |
| 54 | CSNK2A1 | 0.88595407 |
| 55 | CHEK2 | 0.86954547 |
| 56 | MAP2K2 | 0.86461603 |
| 57 | CSNK1G3 | 0.86129038 |
| 58 | CSNK2A2 | 0.84895328 |
| 59 | PASK | 0.83502588 |
| 60 | TEC | 0.82894985 |
| 61 | ILK | 0.82135005 |
| 62 | PLK3 | 0.82104640 |
| 63 | STK38L | 0.79442775 |
| 64 | MAP3K8 | 0.78056542 |
| 65 | OXSR1 | 0.77812861 |
| 66 | TXK | 0.76883462 |
| 67 | TAOK2 | 0.76479787 |
| 68 | TESK1 | 0.73884674 |
| 69 | RPS6KA5 | 0.73472406 |
| 70 | CSF1R | 0.72437374 |
| 71 | EPHA2 | 0.71669424 |
| 72 | NEK1 | 0.71447581 |
| 73 | EIF2AK2 | 0.69384920 |
| 74 | PAK1 | 0.61972520 |
| 75 | SCYL2 | 0.59739445 |
| 76 | ADRBK2 | 0.59668486 |
| 77 | MAP2K4 | 0.59664816 |
| 78 | TGFBR1 | 0.59431603 |
| 79 | PKN1 | 0.59287170 |
| 80 | MST4 | 0.58885076 |
| 81 | ARAF | 0.56938185 |
| 82 | PAK4 | 0.55653114 |
| 83 | CDK4 | 0.55481285 |
| 84 | PRKCI | 0.55435971 |
| 85 | CAMK2G | 0.54411587 |
| 86 | MYLK | 0.54227520 |
| 87 | MAP3K3 | 0.53725984 |
| 88 | DAPK3 | 0.52337016 |
| 89 | STK4 | 0.51482780 |
| 90 | CSNK1G1 | 0.51198078 |
| 91 | IRAK4 | 0.50509064 |
| 92 | WNK4 | 0.49982746 |
| 93 | MAP3K12 | 0.49670538 |
| 94 | TRIB3 | 0.49623765 |
| 95 | NUAK1 | 0.46903138 |
| 96 | PIM1 | 0.46553993 |
| 97 | CSNK1G2 | 0.44344699 |
| 98 | MAP4K1 | 0.44097704 |
| 99 | PRKCD | 0.44007489 |
| 100 | LCK | 0.43785282 |
| 101 | CHEK1 | 0.42531576 |
| 102 | SIK1 | 0.42038706 |
| 103 | MAPK15 | 0.41956545 |
| 104 | CSNK1A1L | 0.40562167 |
| 105 | GRK6 | 0.40291472 |
| 106 | AKT3 | 0.39433795 |
| 107 | BTK | 0.39048219 |
| 108 | CDK2 | 0.37922917 |
| 109 | KIT | 0.37763047 |
| 110 | TBK1 | 0.37299403 |
| 111 | LIMK1 | 0.35435058 |
| 112 | MAP2K3 | 0.34438777 |
| 113 | PHKG1 | 0.34302554 |
| 114 | PHKG2 | 0.34302554 |
| 115 | MAPKAPK3 | 0.33624685 |
| 116 | CAMK2D | 0.33213186 |
| 117 | CASK | 0.32234740 |
| 118 | GRK1 | 0.31781556 |
| 119 | AKT2 | 0.31705919 |
| 120 | ATM | 0.31317276 |
| 121 | SMG1 | 0.31121619 |
| 122 | STK39 | 0.30916132 |
| 123 | DYRK1B | 0.29881988 |
| 124 | TAF1 | 0.29669386 |
| 125 | MUSK | 0.29482804 |
| 126 | IKBKB | 0.29066434 |
| 127 | MAPK4 | 0.29049897 |
| 128 | CSNK1A1 | 0.27732380 |
| 129 | LRRK2 | 0.27108362 |
| 130 | OBSCN | 0.26847524 |
| 131 | RPS6KL1 | 0.25326206 |
| 132 | RPS6KC1 | 0.25326206 |
| 133 | PIK3CG | 0.24949226 |
| 134 | RPS6KA6 | 0.24887614 |
| 135 | MAP2K6 | 0.23970796 |
| 136 | IRAK1 | 0.22802040 |
| 137 | PINK1 | 0.20823362 |
| 138 | NEK9 | 0.20613586 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 5.41521394 |
| 2 | DNA replication_Homo sapiens_hsa03030 | 3.97055982 |
| 3 | Proteasome_Homo sapiens_hsa03050 | 3.80780685 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 3.64911797 |
| 5 | Mismatch repair_Homo sapiens_hsa03430 | 3.31717875 |
| 6 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.95796725 |
| 7 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.78939801 |
| 8 | Parkinsons disease_Homo sapiens_hsa05012 | 2.73763236 |
| 9 | Spliceosome_Homo sapiens_hsa03040 | 2.73444255 |
| 10 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.67774758 |
| 11 | Homologous recombination_Homo sapiens_hsa03440 | 2.66170072 |
| 12 | Base excision repair_Homo sapiens_hsa03410 | 2.39326511 |
| 13 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.35852807 |
| 14 | Huntingtons disease_Homo sapiens_hsa05016 | 2.21987389 |
| 15 | Protein export_Homo sapiens_hsa03060 | 2.14091354 |
| 16 | RNA transport_Homo sapiens_hsa03013 | 2.04236402 |
| 17 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.81936657 |
| 18 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.76019372 |
| 19 | Alzheimers disease_Homo sapiens_hsa05010 | 1.74741343 |
| 20 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.73288942 |
| 21 | Sulfur relay system_Homo sapiens_hsa04122 | 1.73035376 |
| 22 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.71741888 |
| 23 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.61497684 |
| 24 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.54402701 |
| 25 | RNA degradation_Homo sapiens_hsa03018 | 1.53402273 |
| 26 | Basal transcription factors_Homo sapiens_hsa03022 | 1.52090761 |
| 27 | Purine metabolism_Homo sapiens_hsa00230 | 1.50292728 |
| 28 | Cell cycle_Homo sapiens_hsa04110 | 1.40969644 |
| 29 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.33401549 |
| 30 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.22759980 |
| 31 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.21410915 |
| 32 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.20026168 |
| 33 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.19133945 |
| 34 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.11077188 |
| 35 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.08286103 |
| 36 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.06960977 |
| 37 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.03755754 |
| 38 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.03224767 |
| 39 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.01208911 |
| 40 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.99325502 |
| 41 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.86351306 |
| 42 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.85258587 |
| 43 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.85180072 |
| 44 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.84540243 |
| 45 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.81940151 |
| 46 | Carbon metabolism_Homo sapiens_hsa01200 | 0.81334782 |
| 47 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.80288689 |
| 48 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.79833254 |
| 49 | Metabolic pathways_Homo sapiens_hsa01100 | 0.79783182 |
| 50 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.77275339 |
| 51 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.71142666 |
| 52 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.70328267 |
| 53 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.69734441 |
| 54 | Phototransduction_Homo sapiens_hsa04744 | 0.68632370 |
| 55 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.66338300 |
| 56 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.65738876 |
| 57 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.63255186 |
| 58 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.62966011 |
| 59 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.61765255 |
| 60 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.60416812 |
| 61 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.59917829 |
| 62 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.59782652 |
| 63 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.58003356 |
| 64 | Galactose metabolism_Homo sapiens_hsa00052 | 0.57511926 |
| 65 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.55857644 |
| 66 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.53376206 |
| 67 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.52900302 |
| 68 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.51476388 |
| 69 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.51085860 |
| 70 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.49267897 |
| 71 | Peroxisome_Homo sapiens_hsa04146 | 0.49081151 |
| 72 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.47055034 |
| 73 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.44278742 |
| 74 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.42744865 |
| 75 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.42681678 |
| 76 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.41726904 |
| 77 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.41045152 |
| 78 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.38162277 |
| 79 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.37844157 |
| 80 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.37492737 |
| 81 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.37399098 |
| 82 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.36771613 |
| 83 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.36109278 |
| 84 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.35079990 |
| 85 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.34921799 |
| 86 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.34210800 |
| 87 | Retinol metabolism_Homo sapiens_hsa00830 | 0.31795131 |
| 88 | Thyroid cancer_Homo sapiens_hsa05216 | 0.31368775 |
| 89 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.30815289 |
| 90 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.26534006 |
| 91 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.25932979 |
| 92 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.25559280 |
| 93 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.25241103 |
| 94 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.25051981 |
| 95 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.25039739 |
| 96 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.23641761 |
| 97 | Other glycan degradation_Homo sapiens_hsa00511 | 0.22945364 |
| 98 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.22160583 |
| 99 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.19889702 |
| 100 | Histidine metabolism_Homo sapiens_hsa00340 | 0.19104823 |
| 101 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.18045638 |
| 102 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.16830969 |
| 103 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.15732004 |
| 104 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.15623877 |
| 105 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.15581212 |
| 106 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.14147441 |
| 107 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.13779497 |
| 108 | Alcoholism_Homo sapiens_hsa05034 | 0.11944446 |
| 109 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.11254214 |
| 110 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.09698654 |
| 111 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.09195699 |
| 112 | Prion diseases_Homo sapiens_hsa05020 | 0.07657928 |
| 113 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.06491272 |
| 114 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.06258341 |
| 115 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.05876883 |
| 116 | Legionellosis_Homo sapiens_hsa05134 | 0.05279507 |
| 117 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.05107871 |

