BOLA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is located within a region of a segmental duplication on chromosome 16 and is identical to BOLA2B (bolA family member 2B). The product of this gene belongs to a family of proteins that are widely conserved and may be involved in iron maturation. Related pseudogenes are found multiple different chromosomes. Alternative splicing results in multiple transcript variants. Transcripts initiating at this locus may extend into downstream SMG1 pseudogene 6 (SMG1P6) and encode fusion proteins with a C-terminus related to SMG1 phosphatidylinositol 3-kinase-related kinase. A readthrough locus is represented with GeneID:107282092. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)8.19622107
2ribosomal small subunit biogenesis (GO:0042274)7.91044790
3translational termination (GO:0006415)7.88344809
4ribosomal small subunit assembly (GO:0000028)7.09070223
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.89438219
6cotranslational protein targeting to membrane (GO:0006613)6.83843072
7protein targeting to ER (GO:0045047)6.79226200
8translational elongation (GO:0006414)6.60503705
9establishment of protein localization to endoplasmic reticulum (GO:0072599)6.46843477
10protein localization to endoplasmic reticulum (GO:0070972)6.40470081
11ribosomal large subunit biogenesis (GO:0042273)6.22724955
12cellular protein complex disassembly (GO:0043624)6.21710855
13viral life cycle (GO:0019058)6.18338461
14maturation of SSU-rRNA (GO:0030490)6.17877714
15mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.99856664
16nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.84178744
17translational initiation (GO:0006413)5.77114376
18energy coupled proton transport, down electrochemical gradient (GO:0015985)5.73805514
19ATP synthesis coupled proton transport (GO:0015986)5.73805514
20protein complex disassembly (GO:0043241)5.27826659
21mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.14616171
22macromolecular complex disassembly (GO:0032984)5.03247281
23translation (GO:0006412)4.97651727
24proteasome assembly (GO:0043248)4.90060608
25DNA deamination (GO:0045006)4.88055957
26transcription elongation from RNA polymerase III promoter (GO:0006385)4.83413852
27termination of RNA polymerase III transcription (GO:0006386)4.83413852
28respiratory electron transport chain (GO:0022904)4.66645081
29ribonucleoprotein complex biogenesis (GO:0022613)4.59492812
30protein neddylation (GO:0045116)4.54865326
31electron transport chain (GO:0022900)4.54337185
32protein targeting to membrane (GO:0006612)4.43938405
33establishment of protein localization to mitochondrial membrane (GO:0090151)4.29508687
34GTP biosynthetic process (GO:0006183)4.28978196
35chaperone-mediated protein transport (GO:0072321)4.18069184
36nuclear-transcribed mRNA catabolic process (GO:0000956)4.16086008
37cellular component biogenesis (GO:0044085)4.08754947
38mRNA catabolic process (GO:0006402)3.96377974
39protein complex biogenesis (GO:0070271)3.95420078
40regulation of mitochondrial translation (GO:0070129)3.92536925
41water-soluble vitamin biosynthetic process (GO:0042364)3.90893020
42rRNA processing (GO:0006364)3.88121264
43UTP biosynthetic process (GO:0006228)3.87853798
447-methylguanosine mRNA capping (GO:0006370)3.76869216
45rRNA metabolic process (GO:0016072)3.73942807
467-methylguanosine RNA capping (GO:0009452)3.71941609
47RNA capping (GO:0036260)3.71941609
48cullin deneddylation (GO:0010388)3.70843292
49protein deneddylation (GO:0000338)3.70790217
50spliceosomal snRNP assembly (GO:0000387)3.69674204
51mitochondrial respiratory chain complex assembly (GO:0033108)3.69101642
52spliceosomal complex assembly (GO:0000245)3.68438061
53RNA catabolic process (GO:0006401)3.68061984
54NADH dehydrogenase complex assembly (GO:0010257)3.60525458
55mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.60525458
56mitochondrial respiratory chain complex I assembly (GO:0032981)3.60525458
57rRNA methylation (GO:0031167)3.57130305
58negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.54820150
59protein targeting to mitochondrion (GO:0006626)3.52465830
60establishment of integrated proviral latency (GO:0075713)3.52449852
61pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.50793965
62establishment of protein localization to mitochondrion (GO:0072655)3.47491027
63guanosine-containing compound biosynthetic process (GO:1901070)3.38164953
64positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.35176121
65exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.34629138
66tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.34410887
67RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.34410887
68nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.32434531
69protein-cofactor linkage (GO:0018065)3.31741491
70pseudouridine synthesis (GO:0001522)3.31393757
71negative regulation of ligase activity (GO:0051352)3.31201821
72negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.31201821
73transcription from RNA polymerase I promoter (GO:0006360)3.28612251
74DNA damage response, detection of DNA damage (GO:0042769)3.23548921
75positive regulation of ligase activity (GO:0051351)3.21555245
76transcription elongation from RNA polymerase I promoter (GO:0006362)3.21406326
77transcription-coupled nucleotide-excision repair (GO:0006283)3.21277984
78UTP metabolic process (GO:0046051)3.20621758
79base-excision repair, AP site formation (GO:0006285)3.20360337
80maturation of 5.8S rRNA (GO:0000460)3.19863229
81antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.19556173
82positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.18982975
83DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.18080962
84tRNA processing (GO:0008033)3.17767938
85establishment of protein localization to membrane (GO:0090150)3.16389304
86telomere maintenance via semi-conservative replication (GO:0032201)3.15878391
87regulation of cellular amino acid metabolic process (GO:0006521)3.15208255
88protein localization to mitochondrion (GO:0070585)3.15128825
89DNA catabolic process, exonucleolytic (GO:0000738)3.14976462
90CTP biosynthetic process (GO:0006241)3.14910744
91CTP metabolic process (GO:0046036)3.14910744
92deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.13146299
93rRNA modification (GO:0000154)3.12560784
94transcription from mitochondrial promoter (GO:0006390)3.12329801
95establishment of viral latency (GO:0019043)3.11834937
96protein targeting (GO:0006605)3.10704065
97signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.10380277
98intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.10380277
99purine nucleoside triphosphate biosynthetic process (GO:0009145)3.10346899
100signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.09944030
101signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.09944030
102signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.09944030
103regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.09891598
104signal transduction involved in DNA integrity checkpoint (GO:0072401)3.08902705
105signal transduction involved in DNA damage checkpoint (GO:0072422)3.08902705
106pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.07526803
107signal transduction involved in cell cycle checkpoint (GO:0072395)3.05604480
108mitochondrial transport (GO:0006839)3.05264363
109hydrogen ion transmembrane transport (GO:1902600)3.05121993
110termination of RNA polymerase I transcription (GO:0006363)3.04865914
111pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.04436546
112anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.03712326
113ATP biosynthetic process (GO:0006754)3.03136723
114antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.02281519
115DNA replication checkpoint (GO:0000076)3.01682236
116purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.96278906
117ribosome biogenesis (GO:0042254)2.95477640
118formation of translation preinitiation complex (GO:0001731)2.95327420
119regulation of ubiquitin-protein transferase activity (GO:0051438)2.95150569
120peptidyl-histidine modification (GO:0018202)2.94694974
121establishment of protein localization to organelle (GO:0072594)2.94272750
122ncRNA processing (GO:0034470)2.93493710
123cytochrome complex assembly (GO:0017004)2.93125868
124inner mitochondrial membrane organization (GO:0007007)2.92394557
125pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.92357349
126respiratory chain complex IV assembly (GO:0008535)2.92226864
127regulation of cellular amine metabolic process (GO:0033238)2.86081092

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.38924060
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.51167156
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.51011732
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.31027407
5EST1_17652178_ChIP-ChIP_JURKAT_Human4.05102155
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.83668200
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.82022181
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.80850492
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.51967124
10E2F7_22180533_ChIP-Seq_HELA_Human3.50053607
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.46486059
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.37437097
13CREB1_15753290_ChIP-ChIP_HEK293T_Human3.37303432
14MYC_19079543_ChIP-ChIP_MESCs_Mouse3.23185451
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.16156436
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.15152356
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.14473913
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.06990102
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.77555716
20XRN2_22483619_ChIP-Seq_HELA_Human2.68249820
21VDR_23849224_ChIP-Seq_CD4+_Human2.64284225
22DCP1A_22483619_ChIP-Seq_HELA_Human2.46256230
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.39262450
24TTF2_22483619_ChIP-Seq_HELA_Human2.29392152
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.22314157
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.20894654
27E2F4_17652178_ChIP-ChIP_JURKAT_Human2.18367273
28YY1_21170310_ChIP-Seq_MESCs_Mouse2.17694960
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.09705076
30ELK1_19687146_ChIP-ChIP_HELA_Human2.09640133
31FOXP3_21729870_ChIP-Seq_TREG_Human2.05086103
32* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.97434930
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.96620663
34ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.89156846
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.87636031
36GABP_19822575_ChIP-Seq_HepG2_Human1.81085293
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.75757907
38ELK1_22589737_ChIP-Seq_MCF10A_Human1.74110752
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.71267091
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.69122332
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.64608923
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.62605579
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60704798
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.58948061
45CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.57359120
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.56639758
47KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.53631913
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52748198
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50273566
50MYC_18940864_ChIP-ChIP_HL60_Human1.47081931
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44626848
52* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41802796
53SRY_22984422_ChIP-ChIP_TESTIS_Rat1.38036884
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37663019
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36748161
56BP1_19119308_ChIP-ChIP_Hs578T_Human1.34397460
57MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.27513824
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27001430
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25579565
60ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.21207555
61* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18616765
62KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.15863119
63KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.15863119
64KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.15863119
65* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.14036973
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10919971
67NOTCH1_21737748_ChIP-Seq_TLL_Human1.10731791
68BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08810194
69FOXM1_23109430_ChIP-Seq_U2OS_Human1.05437814
70* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05329840
71* E2F1_21310950_ChIP-Seq_MCF-7_Human1.00957741
72CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00038911
73ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99929375
74HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98458526
75CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97299110
76TFEB_21752829_ChIP-Seq_HELA_Human0.96751269
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96675902
78STAT1_20625510_ChIP-Seq_HELA_Human0.96418115
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94976367
80SPI1_23547873_ChIP-Seq_NB4_Human0.94752146
81SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94669434
82ZNF263_19887448_ChIP-Seq_K562_Human0.93253395
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91325440
84PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.90520798
85YY1_22570637_ChIP-Seq_MALME-3M_Human0.89499043
86CIITA_25753668_ChIP-Seq_RAJI_Human0.89322268
87OCT4_18692474_ChIP-Seq_MEFs_Mouse0.86977992
88* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.86146033
89STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85592838
90KDM5A_27292631_Chip-Seq_BREAST_Human0.85474348
91IRF1_19129219_ChIP-ChIP_H3396_Human0.85043654
92* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.84196570
93ELF5_23300383_ChIP-Seq_T47D_Human0.83377027
94PADI4_21655091_ChIP-ChIP_MCF-7_Human0.83231015
95SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82864760
96SOX17_20123909_ChIP-Seq_XEN_Mouse0.82463436
97TP53_22573176_ChIP-Seq_HFKS_Human0.82257031
98FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80238624
99EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.79217354
100IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.79001262
101DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.78265797
102PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.76330492
103ZNF274_21170338_ChIP-Seq_K562_Hela0.76043270
104GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.75264695
105NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.72622663
106POU5F1_16153702_ChIP-ChIP_HESCs_Human0.72234819
107VDR_22108803_ChIP-Seq_LS180_Human0.71967054
108POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.71675602
109* FOXP1_21924763_ChIP-Seq_HESCs_Human0.71648483
110ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.70756834
111HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.69542322
112EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.68580014
113E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.67563197
114AR_20517297_ChIP-Seq_VCAP_Human0.66458748
115ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.64797195
116EGR1_23403033_ChIP-Seq_LIVER_Mouse0.64686467
117RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.64643508
118GATA3_26560356_Chip-Seq_TH2_Human0.64170641

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.53696347
2MP0003806_abnormal_nucleotide_metabolis4.78198780
3MP0003693_abnormal_embryo_hatching3.68458495
4MP0003136_yellow_coat_color3.66840994
5MP0004957_abnormal_blastocyst_morpholog2.66529221
6MP0008932_abnormal_embryonic_tissue2.62871456
7MP0009697_abnormal_copulation2.53661472
8MP0001529_abnormal_vocalization2.39179265
9MP0004381_abnormal_hair_follicle2.27037560
10MP0002132_abnormal_respiratory_system2.17602811
11MP0001986_abnormal_taste_sensitivity2.10967780
12MP0003718_maternal_effect2.08906425
13MP0002277_abnormal_respiratory_mucosa2.05041553
14MP0002837_dystrophic_cardiac_calcinosis2.03875797
15MP0001905_abnormal_dopamine_level2.03310191
16MP0008058_abnormal_DNA_repair2.02951297
17MP0003111_abnormal_nucleus_morphology2.01739669
18MP0003077_abnormal_cell_cycle1.97726718
19MP0003315_abnormal_perineum_morphology1.95583584
20MP0008057_abnormal_DNA_replication1.95172450
21MP0005084_abnormal_gallbladder_morpholo1.93204050
22MP0010094_abnormal_chromosome_stability1.91380033
23MP0006292_abnormal_olfactory_placode1.90194186
24MP0002163_abnormal_gland_morphology1.89023077
25MP0002102_abnormal_ear_morphology1.87381612
26MP0001188_hyperpigmentation1.80163676
27MP0001764_abnormal_homeostasis1.80110585
28MP0009333_abnormal_splenocyte_physiolog1.76863278
29MP0001873_stomach_inflammation1.76389367
30MP0003186_abnormal_redox_activity1.71764544
31MP0008875_abnormal_xenobiotic_pharmacok1.69743508
32MP0003786_premature_aging1.69149787
33MP0000372_irregular_coat_pigmentation1.67102077
34MP0002148_abnormal_hypersensitivity_rea1.65429207
35MP0005409_darkened_coat_color1.62265050
36MP0004142_abnormal_muscle_tone1.61072426
37MP0008872_abnormal_physiological_respon1.55471632
38MP0005174_abnormal_tail_pigmentation1.49602302
39MP0002751_abnormal_autonomic_nervous1.49281584
40MP0002736_abnormal_nociception_after1.45613869
41MP0002638_abnormal_pupillary_reflex1.42714749
42MP0003941_abnormal_skin_development1.40780304
43MP0002938_white_spotting1.40431072
44MP0006276_abnormal_autonomic_nervous1.37040651
45MP0004147_increased_porphyrin_level1.36789291
46MP0004133_heterotaxia1.31945060
47MP0005645_abnormal_hypothalamus_physiol1.29253078
48MP0005646_abnormal_pituitary_gland1.26660372
49MP0005332_abnormal_amino_acid1.25561137
50MP0000490_abnormal_crypts_of1.24562479
51MP0006036_abnormal_mitochondrial_physio1.24105531
52MP0003880_abnormal_central_pattern1.22074595
53MP0008007_abnormal_cellular_replicative1.21245068
54MP0003938_abnormal_ear_development1.20456474
55MP0003646_muscle_fatigue1.19758721
56MP0009785_altered_susceptibility_to1.19614078
57MP0003011_delayed_dark_adaptation1.19133420
58MP0005075_abnormal_melanosome_morpholog1.15380606
59MP0003195_calcinosis1.14482919
60MP0003724_increased_susceptibility_to1.12269442
61MP0002876_abnormal_thyroid_physiology1.12032805
62MP0006035_abnormal_mitochondrial_morpho1.11945218
63MP0008873_increased_physiological_sensi1.10425562
64MP0005636_abnormal_mineral_homeostasis1.09407025
65MP0005408_hypopigmentation1.07673751
66MP0005000_abnormal_immune_tolerance1.06695047
67MP0005410_abnormal_fertilization1.06682032
68MP0001968_abnormal_touch/_nociception1.06413977
69MP0005671_abnormal_response_to1.06228999
70MP0001881_abnormal_mammary_gland1.04872183
71MP0010030_abnormal_orbit_morphology1.04512574
72MP0002019_abnormal_tumor_incidence1.02248244
73MP0000516_abnormal_urinary_system1.01587040
74MP0005367_renal/urinary_system_phenotyp1.01587040
75MP0008877_abnormal_DNA_methylation1.01224125
76MP0005025_abnormal_response_to1.00671892
77MP0000613_abnormal_salivary_gland0.99665543
78MP0000566_synostosis0.96492102
79MP0001727_abnormal_embryo_implantation0.96156024
80MP0002234_abnormal_pharynx_morphology0.95799273
81MP0005379_endocrine/exocrine_gland_phen0.95138623
82MP0000015_abnormal_ear_pigmentation0.94920680
83MP0000685_abnormal_immune_system0.94068584
84MP0002095_abnormal_skin_pigmentation0.93688331
85MP0000049_abnormal_middle_ear0.93408533
86MP0008789_abnormal_olfactory_epithelium0.93126095
87MP0004742_abnormal_vestibular_system0.91062752
88MP0000689_abnormal_spleen_morphology0.91014166
89MP0002160_abnormal_reproductive_system0.89163419
90MP0002723_abnormal_immune_serum0.87531371
91MP0008995_early_reproductive_senescence0.86931183
92MP0005171_absent_coat_pigmentation0.85811482
93MP0000313_abnormal_cell_death0.85719167
94MP0005319_abnormal_enzyme/_coenzyme0.84373450
95MP0000858_altered_metastatic_potential0.83278078
96MP0009764_decreased_sensitivity_to0.83238059
97MP0005451_abnormal_body_composition0.83203449
98MP0001853_heart_inflammation0.82874206
99MP0002693_abnormal_pancreas_physiology0.82260746
100MP0001542_abnormal_bone_strength0.80586919
101MP0008469_abnormal_protein_level0.80133559
102MP0002735_abnormal_chemical_nociception0.80117503
103MP0000762_abnormal_tongue_morphology0.78944430
104MP0001845_abnormal_inflammatory_respons0.78352793
105MP0002452_abnormal_antigen_presenting0.78128038
106MP0001929_abnormal_gametogenesis0.78127611
107MP0004043_abnormal_pH_regulation0.77067582
108MP0003123_paternal_imprinting0.76764581
109MP0005381_digestive/alimentary_phenotyp0.76702612
110MP0005389_reproductive_system_phenotype0.76458312
111MP0001800_abnormal_humoral_immune0.76043660
112MP0001819_abnormal_immune_cell0.75391397
113MP0002420_abnormal_adaptive_immunity0.75338584
114MP0001835_abnormal_antigen_presentation0.74635057
115MP0004019_abnormal_vitamin_homeostasis0.74508902
116MP0000653_abnormal_sex_gland0.73644966
117MP0003866_abnormal_defecation0.72773511
118MP0008260_abnormal_autophagy0.72186597
119MP0001663_abnormal_digestive_system0.71968873
120MP0002405_respiratory_system_inflammati0.71840245
121MP0002210_abnormal_sex_determination0.71412679
122MP0003436_decreased_susceptibility_to0.71325614
123MP0000350_abnormal_cell_proliferation0.70859490
124MP0001145_abnormal_male_reproductive0.70542093
125MP0000358_abnormal_cell_content/0.70451047
126MP0005387_immune_system_phenotype0.70094170
127MP0001790_abnormal_immune_system0.70094170
128MP0003763_abnormal_thymus_physiology0.69985632
129MP0001485_abnormal_pinna_reflex0.69798963
130MP0001119_abnormal_female_reproductive0.69730312
131MP0000026_abnormal_inner_ear0.65391100
132MP0009250_abnormal_appendicular_skeleto0.65305719
133MP0001919_abnormal_reproductive_system0.65075551
134MP0002722_abnormal_immune_system0.64339663
135MP0002398_abnormal_bone_marrow0.64013765
136MP0002429_abnormal_blood_cell0.63588743
137MP0006082_CNS_inflammation0.63202050
138MP0000703_abnormal_thymus_morphology0.63020788
139MP0000716_abnormal_immune_system0.63017234
140MP0006072_abnormal_retinal_apoptosis0.62706385
141MP0000681_abnormal_thyroid_gland0.62337060

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.40496925
2Reticulocytopenia (HP:0001896)5.85396324
3Acute necrotizing encephalopathy (HP:0006965)5.73256488
4Abnormal number of erythroid precursors (HP:0012131)5.62543176
5Mitochondrial inheritance (HP:0001427)5.30747582
6Abnormal mitochondria in muscle tissue (HP:0008316)5.03601265
7Macrocytic anemia (HP:0001972)5.00854327
8Increased hepatocellular lipid droplets (HP:0006565)4.71877082
9Progressive macrocephaly (HP:0004481)4.67395449
10Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.66753047
11Pallor (HP:0000980)4.53069839
12Hepatocellular necrosis (HP:0001404)4.48577604
13Acute encephalopathy (HP:0006846)4.40940029
14Increased CSF lactate (HP:0002490)4.37652846
15Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.36458195
163-Methylglutaconic aciduria (HP:0003535)4.18219715
17Decreased activity of mitochondrial respiratory chain (HP:0008972)4.06233514
18Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.06233514
19Renal Fanconi syndrome (HP:0001994)4.01333675
20Lipid accumulation in hepatocytes (HP:0006561)3.93739654
21Aplasia/Hypoplasia of the sacrum (HP:0008517)3.84534768
22Exertional dyspnea (HP:0002875)3.72592112
23Hepatic necrosis (HP:0002605)3.65636519
24Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.58883361
25Increased intramyocellular lipid droplets (HP:0012240)3.26065276
26Methylmalonic aciduria (HP:0012120)3.24209925
27Exercise intolerance (HP:0003546)3.19984960
28Abnormal hemoglobin (HP:0011902)3.18285974
29Increased serum lactate (HP:0002151)3.17694892
30Respiratory failure (HP:0002878)3.11671692
31Optic disc pallor (HP:0000543)3.09269893
32Methylmalonic acidemia (HP:0002912)3.05388954
33Leukodystrophy (HP:0002415)2.85214509
34Cerebral edema (HP:0002181)2.82135831
35Breast hypoplasia (HP:0003187)2.79409315
36Cerebral hypomyelination (HP:0006808)2.78002042
37Parakeratosis (HP:0001036)2.75963936
38Abnormal protein glycosylation (HP:0012346)2.75775100
39Abnormal glycosylation (HP:0012345)2.75775100
40Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.75775100
41Abnormal protein N-linked glycosylation (HP:0012347)2.75775100
42Lethargy (HP:0001254)2.75321644
43Lactic acidosis (HP:0003128)2.64563168
44Congenital ichthyosiform erythroderma (HP:0007431)2.59114646
45Respiratory difficulties (HP:0002880)2.57258392
46Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.55136049
47Abnormality of alanine metabolism (HP:0010916)2.55136049
48Hyperalaninemia (HP:0003348)2.55136049
49Reduced antithrombin III activity (HP:0001976)2.52926843
50Increased muscle lipid content (HP:0009058)2.48515814
51Concave nail (HP:0001598)2.46364301
52Abnormality of renal resorption (HP:0011038)2.43981885
53Microvesicular hepatic steatosis (HP:0001414)2.40935319
54IgG deficiency (HP:0004315)2.40500945
55Rough bone trabeculation (HP:0100670)2.34450771
56Triphalangeal thumb (HP:0001199)2.31742384
57Dicarboxylic aciduria (HP:0003215)2.29176744
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.29176744
59Oral leukoplakia (HP:0002745)2.28684871
60Aplastic anemia (HP:0001915)2.27289486
61Glycosuria (HP:0003076)2.23752721
62Abnormality of urine glucose concentration (HP:0011016)2.23752721
63Abnormality of methionine metabolism (HP:0010901)2.22403699
64Abnormality of the anterior horn cell (HP:0006802)2.21562555
65Degeneration of anterior horn cells (HP:0002398)2.21562555
66Abnormality of glycolysis (HP:0004366)2.17281395
67Increased serum pyruvate (HP:0003542)2.17281395
68Absent thumb (HP:0009777)2.15292685
69Type I transferrin isoform profile (HP:0003642)2.15009231
70Amniotic constriction ring (HP:0009775)2.14427208
71Abnormality of placental membranes (HP:0011409)2.14427208
72Aplasia/hypoplasia of the uterus (HP:0008684)2.13206462
73Trismus (HP:0000211)2.10559467
74Progressive external ophthalmoplegia (HP:0000590)2.10526933
75Generalized aminoaciduria (HP:0002909)2.10083094
76B lymphocytopenia (HP:0010976)2.08204105
77Abnormality of aspartate family amino acid metabolism (HP:0010899)2.06052591
78Depressed nasal ridge (HP:0000457)2.02468616
79Abnormality of serum amino acid levels (HP:0003112)2.02321724
80Horseshoe kidney (HP:0000085)2.02254147
81Carpal bone hypoplasia (HP:0001498)2.00662969
82Asplenia (HP:0001746)2.00350785
83Cleft eyelid (HP:0000625)1.97813168
84Opisthotonus (HP:0002179)1.97634279
85Partial duplication of thumb phalanx (HP:0009944)1.97610420
86Abnormal trabecular bone morphology (HP:0100671)1.97099446
87Hyperphosphaturia (HP:0003109)1.96892708
88Abnormality of B cell number (HP:0010975)1.95983331
89Poor head control (HP:0002421)1.95100294
90Emotional lability (HP:0000712)1.93185026
91Progressive microcephaly (HP:0000253)1.91929012
92Hypoplasia of the radius (HP:0002984)1.91686753
93Partial duplication of the phalanx of hand (HP:0009999)1.89150272
94Birth length less than 3rd percentile (HP:0003561)1.85995804
95Premature graying of hair (HP:0002216)1.84926684
96CNS demyelination (HP:0007305)1.84067831
97Abnormality of vitamin B metabolism (HP:0004340)1.82778032
98Stenosis of the external auditory canal (HP:0000402)1.82728225
99Sensory axonal neuropathy (HP:0003390)1.80604935
100IgM deficiency (HP:0002850)1.80548239
101Abnormality of the vitamin B12 metabolism (HP:0004341)1.78682127
102Obstructive lung disease (HP:0006536)1.78228251
103Chronic obstructive pulmonary disease (HP:0006510)1.78228251
104Abnormal pupillary function (HP:0007686)1.77155859
105Pancytopenia (HP:0001876)1.76309369
106Secondary amenorrhea (HP:0000869)1.76015483
107Neutropenia (HP:0001875)1.75634855
108Aplasia/Hypoplasia of the spleen (HP:0010451)1.75472410
109Duplicated collecting system (HP:0000081)1.72690764
110Abnormality of aromatic amino acid family metabolism (HP:0004338)1.71850330
111Sparse eyelashes (HP:0000653)1.71409921
112Duplication of thumb phalanx (HP:0009942)1.70995423
113Hypoplasia of the pons (HP:0012110)1.70114622
114Absent radius (HP:0003974)1.69461134
115Congenital, generalized hypertrichosis (HP:0004540)1.69408351
116Aplasia/Hypoplasia of the patella (HP:0006498)1.68430107
117Abnormality of the preputium (HP:0100587)1.67998294
118Palpitations (HP:0001962)1.66966149
119Homocystinuria (HP:0002156)1.66829755
120Abnormality of homocysteine metabolism (HP:0010919)1.66829755
121Patellar aplasia (HP:0006443)1.66420589
122Aplasia/Hypoplasia involving the musculature (HP:0001460)1.65965595
123Abnormal urine phosphate concentration (HP:0012599)1.65864857
124Abnormality of T cell physiology (HP:0011840)1.65438425
125Pancreatic cysts (HP:0001737)1.64411170
126Decreased electroretinogram (ERG) amplitude (HP:0000654)1.63081692
127Supernumerary spleens (HP:0009799)1.61938836
128Renal tubular dysfunction (HP:0000124)1.61298721
129Hyperglycinemia (HP:0002154)1.60931173
130Abnormality of the axillary hair (HP:0100134)1.60892031
131Abnormality of secondary sexual hair (HP:0009888)1.60892031
132Metabolic acidosis (HP:0001942)1.59990899
133Vomiting (HP:0002013)1.59731498
134Hypergonadotropic hypogonadism (HP:0000815)1.59643160
135Abnormality of the pons (HP:0007361)1.59395274
136Aplasia involving forearm bones (HP:0009822)1.58748339
137Absent forearm bone (HP:0003953)1.58748339
138Microretrognathia (HP:0000308)1.57205567
139X-linked dominant inheritance (HP:0001423)1.55046586
140Nasolacrimal duct obstruction (HP:0000579)1.53954606
141Abnormality of reticulocytes (HP:0004312)1.53836603
142Testicular atrophy (HP:0000029)1.50876499
143Migraine (HP:0002076)1.49713665
144Blindness (HP:0000618)1.49008154

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.33025198
2TLK14.85444624
3VRK24.74505056
4STK163.67506123
5BUB13.54316078
6EIF2AK12.95056324
7WEE12.50637586
8SRPK12.47076590
9NUAK12.45767202
10PBK2.45246694
11PIM22.43092896
12TESK22.29183974
13BCKDK2.21392937
14VRK12.18546023
15NME12.10533082
16CDK192.05306868
17CASK1.98401127
18ARAF1.87846506
19IRAK31.85697573
20MAP4K21.76506070
21BRAF1.74168123
22PLK41.60058068
23BLK1.54252818
24MST41.47974721
25IRAK41.43656255
26LIMK11.39875258
27NEK11.38047753
28MKNK21.37266784
29EIF2AK31.35107551
30MKNK11.29352920
31MAP3K121.28447591
32SCYL21.18901199
33TAF11.17937679
34GRK51.16644826
35MAP3K111.12339628
36ABL21.08848723
37GRK11.08502064
38STK391.08030424
39PDK21.07347972
40DYRK21.05783319
41AURKA1.05299729
42GRK71.01151026
43ZAK0.98421871
44IRAK10.97885101
45IRAK20.96555417
46DAPK10.95431875
47MAP2K20.95383956
48CDC70.94866669
49INSRR0.92796038
50DAPK30.92427261
51PLK10.91561597
52CDK70.91254855
53CSNK1G20.91033212
54EIF2AK20.89752593
55TAOK30.89167918
56PNCK0.88722555
57TESK10.88051231
58BMPR1B0.87642144
59ADRBK20.87497504
60FRK0.87057840
61DYRK30.86232413
62RPS6KA50.82106370
63TRIM280.80873363
64CLK10.79965242
65CSNK1A1L0.79361641
66KDR0.76963010
67MAPKAPK30.76591568
68PAK10.75565416
69IKBKB0.74690134
70BRSK20.74370542
71CDK80.72242405
72AURKB0.71702597
73CSNK2A20.70816317
74TSSK60.70609428
75CSNK2A10.70028097
76WNK30.69634767
77RPS6KB20.69621670
78MAPKAPK50.67316839
79PHKG20.67133881
80PHKG10.67133881
81CCNB10.64889251
82TXK0.63921153
83TTK0.63626856
84CSNK1G30.58716452
85PIM10.58687276
86UHMK10.57363143
87TNIK0.55959766
88ILK0.55645998
89PRKCI0.53949286
90TEC0.52530227
91YES10.51469424
92PKN10.50593686
93MAP3K80.50233358
94RPS6KA40.49190238
95ADRBK10.48830244
96LYN0.48515628
97EPHA20.48000201
98MYLK0.47191745
99MAP4K10.46884705
100OXSR10.46797078
101BCR0.46530470
102TBK10.45446137
103CHEK20.44567453
104FES0.43639830
105PAK40.42665718
106STK40.41766203
107CAMK2B0.41707032
108PLK30.41677564
109LRRK20.41601060
110FGR0.37761387
111ATR0.35019353
112MUSK0.34809205
113CSNK1A10.34563579
114ATM0.34524265
115IKBKE0.34293889
116MAP2K60.34109543
117BMPR20.33731102
118PRKCQ0.33296914
119BRSK10.32835217
120CSNK1G10.32753116
121CDK11A0.31985664
122MOS0.30004597
123SYK0.29916942
124CHEK10.29546246
125MAP2K70.29122954
126CAMK2D0.28666005
127CDK140.28573073
128CAMK2G0.28542291
129ITK0.28362272
130GRK60.27932049
131KIT0.27677741
132LCK0.26983915
133WNK40.26886929
134MAPK40.25108812

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.62860056
2Oxidative phosphorylation_Homo sapiens_hsa001904.39736182
3RNA polymerase_Homo sapiens_hsa030203.95635604
4Proteasome_Homo sapiens_hsa030503.85005237
5Parkinsons disease_Homo sapiens_hsa050123.83674261
6Huntingtons disease_Homo sapiens_hsa050162.94111848
7DNA replication_Homo sapiens_hsa030302.73993023
8Alzheimers disease_Homo sapiens_hsa050102.72558857
9Protein export_Homo sapiens_hsa030602.61782308
10Homologous recombination_Homo sapiens_hsa034402.42636939
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.41389919
12Pyrimidine metabolism_Homo sapiens_hsa002402.41106814
13Spliceosome_Homo sapiens_hsa030402.38346093
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.34941732
15Mismatch repair_Homo sapiens_hsa034302.31845841
16Nucleotide excision repair_Homo sapiens_hsa034201.98280733
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.96703488
18Base excision repair_Homo sapiens_hsa034101.64262157
19Fanconi anemia pathway_Homo sapiens_hsa034601.53878104
20Basal transcription factors_Homo sapiens_hsa030221.52709166
21Cardiac muscle contraction_Homo sapiens_hsa042601.42808670
22RNA transport_Homo sapiens_hsa030131.42371769
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.37056346
24Sulfur relay system_Homo sapiens_hsa041221.35413147
25Purine metabolism_Homo sapiens_hsa002301.27952887
26RNA degradation_Homo sapiens_hsa030181.13486815
27Non-homologous end-joining_Homo sapiens_hsa034501.03436036
28One carbon pool by folate_Homo sapiens_hsa006700.99769995
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95206257
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95158183
31Folate biosynthesis_Homo sapiens_hsa007900.93831391
32Systemic lupus erythematosus_Homo sapiens_hsa053220.89217559
33Cell cycle_Homo sapiens_hsa041100.87041039
34Epstein-Barr virus infection_Homo sapiens_hsa051690.82476113
35Arachidonic acid metabolism_Homo sapiens_hsa005900.82331892
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79741987
37Graft-versus-host disease_Homo sapiens_hsa053320.76829932
38Caffeine metabolism_Homo sapiens_hsa002320.76692994
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76217690
40Glutathione metabolism_Homo sapiens_hsa004800.74471889
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71880014
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69935879
43Steroid biosynthesis_Homo sapiens_hsa001000.69746117
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68648288
45p53 signaling pathway_Homo sapiens_hsa041150.67449049
46Allograft rejection_Homo sapiens_hsa053300.65494526
47Ether lipid metabolism_Homo sapiens_hsa005650.65034819
48Selenocompound metabolism_Homo sapiens_hsa004500.62955239
49Collecting duct acid secretion_Homo sapiens_hsa049660.61700178
50Metabolic pathways_Homo sapiens_hsa011000.61535142
51Peroxisome_Homo sapiens_hsa041460.61436590
52Linoleic acid metabolism_Homo sapiens_hsa005910.60314261
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59887139
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59578245
55Sphingolipid metabolism_Homo sapiens_hsa006000.59395442
56Asthma_Homo sapiens_hsa053100.57642470
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.57176176
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55175129
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54983501
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53681884
61Rheumatoid arthritis_Homo sapiens_hsa053230.52668097
62Pyruvate metabolism_Homo sapiens_hsa006200.52329148
63Vitamin digestion and absorption_Homo sapiens_hsa049770.51071203
64N-Glycan biosynthesis_Homo sapiens_hsa005100.50930927
65Chemical carcinogenesis_Homo sapiens_hsa052040.49935143
66Autoimmune thyroid disease_Homo sapiens_hsa053200.48987180
67Propanoate metabolism_Homo sapiens_hsa006400.48488591
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47363393
69Other glycan degradation_Homo sapiens_hsa005110.46058788
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45621168
71Primary immunodeficiency_Homo sapiens_hsa053400.43624321
72Vibrio cholerae infection_Homo sapiens_hsa051100.42941741
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42124124
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41433816
75Hematopoietic cell lineage_Homo sapiens_hsa046400.39721112
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39698217
77Fatty acid elongation_Homo sapiens_hsa000620.38341888
78Alcoholism_Homo sapiens_hsa050340.37788938
79Phototransduction_Homo sapiens_hsa047440.37402699
80Herpes simplex infection_Homo sapiens_hsa051680.36811015
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35597097
82mRNA surveillance pathway_Homo sapiens_hsa030150.35075239
83Pentose phosphate pathway_Homo sapiens_hsa000300.33726120
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.32627230
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32398370
86Phagosome_Homo sapiens_hsa041450.32261734
87Tryptophan metabolism_Homo sapiens_hsa003800.32124811
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31653209
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.30007536
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29558875
91Retinol metabolism_Homo sapiens_hsa008300.28447255
92Nitrogen metabolism_Homo sapiens_hsa009100.27576555
93Sulfur metabolism_Homo sapiens_hsa009200.27349866
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27325135
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27260147
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.26976706
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26898214
98Carbon metabolism_Homo sapiens_hsa012000.25488337
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.22521651
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.22425385
101Regulation of autophagy_Homo sapiens_hsa041400.20961688
1022-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.20466014
103Arginine and proline metabolism_Homo sapiens_hsa003300.19483121
104Mineral absorption_Homo sapiens_hsa049780.18397219
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.18252852
106Pertussis_Homo sapiens_hsa051330.18047582
107Malaria_Homo sapiens_hsa051440.17889346
108Cyanoamino acid metabolism_Homo sapiens_hsa004600.16304910
109Biosynthesis of amino acids_Homo sapiens_hsa012300.16298461
110Antigen processing and presentation_Homo sapiens_hsa046120.16099475
111Viral carcinogenesis_Homo sapiens_hsa052030.14576824
112Vitamin B6 metabolism_Homo sapiens_hsa007500.14137115
113Measles_Homo sapiens_hsa051620.12363205
114Apoptosis_Homo sapiens_hsa042100.11698003
115Cysteine and methionine metabolism_Homo sapiens_hsa002700.11611382
116Shigellosis_Homo sapiens_hsa051310.11266911
117Hedgehog signaling pathway_Homo sapiens_hsa043400.11171849
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.11119545
119Legionellosis_Homo sapiens_hsa051340.10383029
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.10034021
121African trypanosomiasis_Homo sapiens_hsa051430.09034119
122Tyrosine metabolism_Homo sapiens_hsa003500.08983154
123Oocyte meiosis_Homo sapiens_hsa041140.06912470
124Basal cell carcinoma_Homo sapiens_hsa052170.06295605
125Salmonella infection_Homo sapiens_hsa051320.05561627
126Leishmaniasis_Homo sapiens_hsa051400.05445940
127Phenylalanine metabolism_Homo sapiens_hsa003600.05441918
128Type I diabetes mellitus_Homo sapiens_hsa049400.05155687

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