BOLA2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine ribonucleoside catabolic process (GO:0046133)9.38489329
2cellular anion homeostasis (GO:0030002)6.28535697
3regulation of Wnt signaling pathway involved in heart development (GO:0003307)5.64295112
4negative regulation of cell fate specification (GO:0009996)5.51880696
5secondary heart field specification (GO:0003139)5.46719449
6heart field specification (GO:0003128)5.46719449
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.20172055
8cell migration involved in heart development (GO:0060973)5.14933737
9sequestering of actin monomers (GO:0042989)5.10455413
10positive regulation of cell fate commitment (GO:0010455)4.78925777
11ATP synthesis coupled proton transport (GO:0015986)4.62405482
12energy coupled proton transport, down electrochemical gradient (GO:0015985)4.62405482
13pyrimidine nucleoside catabolic process (GO:0046135)4.45400244
14L-fucose catabolic process (GO:0042355)4.39665072
15fucose catabolic process (GO:0019317)4.39665072
16L-fucose metabolic process (GO:0042354)4.39665072
17positive regulation of fibroblast migration (GO:0010763)4.38859290
18viral transcription (GO:0019083)4.20514573
19cardiac ventricle formation (GO:0003211)4.14206826
20maturation of SSU-rRNA (GO:0030490)4.12990800
21mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.09703004
22positive regulation of endothelial cell apoptotic process (GO:2000353)4.08895192
23negative regulation of cell fate commitment (GO:0010454)4.05526356
24translational termination (GO:0006415)4.04385883
25positive regulation of calcium-mediated signaling (GO:0050850)3.97225268
26positive regulation of interleukin-8 secretion (GO:2000484)3.96137569
27ribosomal small subunit assembly (GO:0000028)3.95148114
28positive regulation of defense response to virus by host (GO:0002230)3.89810438
29cardiac chamber formation (GO:0003207)3.89483710
30respiratory electron transport chain (GO:0022904)3.82020867
31specification of organ identity (GO:0010092)3.79654688
32positive regulation of interleukin-17 production (GO:0032740)3.78221117
33negative regulation by host of viral transcription (GO:0043922)3.77324735
34SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.73096272
35electron transport chain (GO:0022900)3.70807291
36cotranslational protein targeting to membrane (GO:0006613)3.69666725
37cell migration involved in gastrulation (GO:0042074)3.69615862
38T cell apoptotic process (GO:0070231)3.64724847
39protein targeting to ER (GO:0045047)3.63640100
40regulation of mesoderm development (GO:2000380)3.62603892
41translational elongation (GO:0006414)3.59054225
42necroptotic process (GO:0070266)3.55791369
43DNA demethylation (GO:0080111)3.52503294
44somite rostral/caudal axis specification (GO:0032525)3.45291534
45establishment of protein localization to endoplasmic reticulum (GO:0072599)3.42183580
46regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.41965332
47positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.41965332
48chaperone-mediated protein transport (GO:0072321)3.41239096
49sleep (GO:0030431)3.38887258
50positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.35447633
51behavioral response to nicotine (GO:0035095)3.34622237
52protein localization to endoplasmic reticulum (GO:0070972)3.34484136
53T cell migration (GO:0072678)3.32100327
54negative regulation of viral genome replication (GO:0045071)3.31035637
55eosinophil chemotaxis (GO:0048245)3.26972791
56positive regulation of lamellipodium organization (GO:1902745)3.20112062
57cytolysis (GO:0019835)3.14709644
58regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.13081385
59positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.13081385
60DNA dealkylation (GO:0035510)3.12254525
61cellular protein complex disassembly (GO:0043624)3.10502325
62regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.08744683
63positive regulation of alpha-beta T cell proliferation (GO:0046641)3.08026243
64establishment of protein localization to mitochondrial membrane (GO:0090151)3.04974790
65intracellular pH reduction (GO:0051452)3.03160988
66pyrimidine-containing compound catabolic process (GO:0072529)3.02980233
67growth hormone receptor signaling pathway (GO:0060396)3.02585709
68lymphocyte apoptotic process (GO:0070227)3.01161689
69viral life cycle (GO:0019058)3.00541423
70eosinophil migration (GO:0072677)2.99107349
71negative regulation of telomere maintenance (GO:0032205)2.91831112
72macrophage chemotaxis (GO:0048246)2.87272289
73regulation of alpha-beta T cell proliferation (GO:0046640)2.83546247
74extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625)2.83354838
75positive regulation of B cell differentiation (GO:0045579)2.81417146
76positive T cell selection (GO:0043368)2.80125075
77protein complex biogenesis (GO:0070271)2.80111428
78regulation of lymphocyte chemotaxis (GO:1901623)2.79148754
79ATP biosynthetic process (GO:0006754)2.75754876
80positive thymic T cell selection (GO:0045059)2.74836540
81regulation of calcium-mediated signaling (GO:0050848)2.73879546
82negative regulation of T cell apoptotic process (GO:0070233)2.73707552
83positive regulation of prostaglandin secretion (GO:0032308)2.73579236
84cellular response to growth hormone stimulus (GO:0071378)2.72543261
85positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.70407090
86signal transduction involved in regulation of gene expression (GO:0023019)2.70097429
87translational initiation (GO:0006413)2.66052819
88endothelial cell differentiation (GO:0045446)2.65813924
89positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.65767245
90pH reduction (GO:0045851)2.65617252
91nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.65139126
92hydrogen peroxide biosynthetic process (GO:0050665)2.64397435
93platelet dense granule organization (GO:0060155)2.64394186
94positive regulation of ERBB signaling pathway (GO:1901186)2.64219512
95programmed necrotic cell death (GO:0097300)2.63283338
96regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:004509111.8099461
97DNA deamination (GO:0045006)11.0550253
98cytidine catabolic process (GO:0006216)10.6727238
99cytidine deamination (GO:0009972)10.6727238
100cytidine metabolic process (GO:0046087)10.6727238

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.28027940
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.39841405
3ELF1_17652178_ChIP-ChIP_JURKAT_Human4.13734600
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.60253911
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.39871503
6CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.38886690
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.17624712
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.08200705
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.04789394
10VDR_22108803_ChIP-Seq_LS180_Human2.96943748
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.83628979
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.80638859
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.73841372
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.73822039
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.47013644
16EZH2_22144423_ChIP-Seq_EOC_Human2.43704305
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.39298184
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.05953229
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.05581691
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.05452110
21NOTCH1_21737748_ChIP-Seq_TLL_Human1.86911909
22MYC_18940864_ChIP-ChIP_HL60_Human1.86268113
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.83585294
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.83378988
25RUNX_20019798_ChIP-Seq_JUKART_Human1.76756160
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74048507
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.65267931
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63663536
29VDR_23849224_ChIP-Seq_CD4+_Human1.57205205
30ETV2_25802403_ChIP-Seq_MESCs_Mouse1.53966555
31ELK1_19687146_ChIP-ChIP_HELA_Human1.52292372
32ZNF274_21170338_ChIP-Seq_K562_Hela1.50006932
33TAF2_19829295_ChIP-Seq_ESCs_Human1.48000296
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47154416
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44227619
36ERG_20517297_ChIP-Seq_VCAP_Human1.40020646
37TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.39724381
38PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.39376161
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35526676
40TP53_22573176_ChIP-Seq_HFKS_Human1.35515564
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34554478
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.31979275
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.30618608
44RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.29146378
45FOXA1_21572438_ChIP-Seq_LNCaP_Human1.29053285
46ETS1_20019798_ChIP-Seq_JURKAT_Human1.28992485
47PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.27732694
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.27284177
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24638059
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24040891
51P300_19829295_ChIP-Seq_ESCs_Human1.22101277
52EGR1_23403033_ChIP-Seq_LIVER_Mouse1.19036588
53HTT_18923047_ChIP-ChIP_STHdh_Human1.18504144
54FOXP3_21729870_ChIP-Seq_TREG_Human1.17975907
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15690209
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.15690209
57GATA3_27048872_Chip-Seq_THYMUS_Human1.14512439
58GATA3_21878914_ChIP-Seq_MCF-7_Human1.12345999
59AR_20517297_ChIP-Seq_VCAP_Human1.11803959
60GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.10568715
61IRF8_21731497_ChIP-ChIP_J774_Mouse1.09865200
62GATA6_21074721_ChIP-Seq_CACO-2_Human1.09227400
63EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08222133
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.08153061
65NANOG_20526341_ChIP-Seq_ESCs_Human1.07346573
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06715177
67FOXH1_21741376_ChIP-Seq_EPCs_Human1.05308271
68STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05188984
69MYB_26560356_Chip-Seq_TH2_Human1.05164783
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04581095
71GATA3_26560356_Chip-Seq_TH2_Human1.03152757
72OCT4_20526341_ChIP-Seq_ESCs_Human1.02756989
73CTCF_20526341_ChIP-Seq_ESCs_Human1.01995531
74FUS_26573619_Chip-Seq_HEK293_Human1.00273008
75NCOR_22424771_ChIP-Seq_293T_Human0.99585980
76MYC_19829295_ChIP-Seq_ESCs_Human0.98829300
77RBPJ_21746931_ChIP-Seq_IB4_Human0.98441534
78HOXB7_26014856_ChIP-Seq_BT474_Human0.98418565
79E2F4_17652178_ChIP-ChIP_JURKAT_Human0.98279327
80EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97816836
81CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94555766
82CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94265453
83ERA_21632823_ChIP-Seq_H3396_Human0.94208136
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94039934
85TDRD3_21172665_ChIP-Seq_MCF-7_Human0.93071851
86AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92619554
87RNF2_27304074_Chip-Seq_NSC_Mouse0.91682252
88ELK1_22589737_ChIP-Seq_MCF10A_Human0.90188323
89GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.89269432
90LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.88960365
91ER_23166858_ChIP-Seq_MCF-7_Human0.88144385
92FOXH1_21741376_ChIP-Seq_ESCs_Human0.88024186
93P53_21459846_ChIP-Seq_SAOS-2_Human0.87973168
94PHF8_20622853_ChIP-Seq_HELA_Human0.87834189
95EWS_26573619_Chip-Seq_HEK293_Human0.87687976
96JARID2_20064375_ChIP-Seq_MESCs_Mouse0.86494779
97ZNF263_19887448_ChIP-Seq_K562_Human0.86397182
98TAF15_26573619_Chip-Seq_HEK293_Human0.85373705
99RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.85256504
100EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.84532932

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002234_abnormal_pharynx_morphology6.43682462
2MP0005671_abnormal_response_to4.22733090
3MP0001873_stomach_inflammation3.81059833
4MP0006082_CNS_inflammation3.61761343
5MP0000566_synostosis3.48117792
6MP0009379_abnormal_foot_pigmentation3.46362322
7MP0002822_catalepsy2.31184518
8MP0009785_altered_susceptibility_to2.19216506
9MP0002837_dystrophic_cardiac_calcinosis2.17611392
10MP0009333_abnormal_splenocyte_physiolog2.10861478
11MP0003136_yellow_coat_color1.95810738
12MP0003763_abnormal_thymus_physiology1.94930235
13MP0006292_abnormal_olfactory_placode1.92230264
14MP0005646_abnormal_pituitary_gland1.88837325
15MP0003880_abnormal_central_pattern1.79648855
16MP0001485_abnormal_pinna_reflex1.73068406
17MP0005377_hearing/vestibular/ear_phenot1.69138123
18MP0003878_abnormal_ear_physiology1.69138123
19MP0001835_abnormal_antigen_presentation1.65830019
20MP0001529_abnormal_vocalization1.64897043
21MP0004130_abnormal_muscle_cell1.64183089
22MP0008995_early_reproductive_senescence1.50602667
23MP0002102_abnormal_ear_morphology1.47017441
24MP0006072_abnormal_retinal_apoptosis1.46991000
25MP0003011_delayed_dark_adaptation1.45177863
26MP0005025_abnormal_response_to1.44843442
27MP0002148_abnormal_hypersensitivity_rea1.41839150
28MP0005000_abnormal_immune_tolerance1.40640526
29MP0008875_abnormal_xenobiotic_pharmacok1.37988889
30MP0002277_abnormal_respiratory_mucosa1.36135203
31MP0008877_abnormal_DNA_methylation1.34644880
32MP0005360_urolithiasis1.30438117
33MP0003786_premature_aging1.29893181
34MP0000631_abnormal_neuroendocrine_gland1.29552250
35MP0003646_muscle_fatigue1.27731546
36MP0004145_abnormal_muscle_electrophysio1.23080119
37MP0008872_abnormal_physiological_respon1.22890639
38MP0000465_gastrointestinal_hemorrhage1.22885082
39MP0001800_abnormal_humoral_immune1.21195751
40MP0002420_abnormal_adaptive_immunity1.18827520
41MP0004147_increased_porphyrin_level1.17922444
42MP0001905_abnormal_dopamine_level1.15532422
43MP0001819_abnormal_immune_cell1.12054228
44MP0002938_white_spotting1.10455683
45MP0003567_abnormal_fetal_cardiomyocyte1.07342397
46MP0004510_myositis1.05643039
47MP0002723_abnormal_immune_serum1.05544980
48MP0001663_abnormal_digestive_system1.05106090
49MP0001346_abnormal_lacrimal_gland1.05102528
50MP0001919_abnormal_reproductive_system1.03948243
51MP0001790_abnormal_immune_system1.02825815
52MP0005387_immune_system_phenotype1.02825815
53MP0000685_abnormal_immune_system1.00803671
54MP0002638_abnormal_pupillary_reflex0.99874834
55MP0004885_abnormal_endolymph0.97785284
56MP0005645_abnormal_hypothalamus_physiol0.97183457
57MP0003866_abnormal_defecation0.96096997
58MP0002693_abnormal_pancreas_physiology0.95238775
59MP0000703_abnormal_thymus_morphology0.93373878
60MP0008873_increased_physiological_sensi0.92095821
61MP0005551_abnormal_eye_electrophysiolog0.91601758
62MP0005166_decreased_susceptibility_to0.91279168
63MP0000372_irregular_coat_pigmentation0.91216979
64MP0009745_abnormal_behavioral_response0.90173942
65MP0010386_abnormal_urinary_bladder0.89233811
66MP0001188_hyperpigmentation0.89209911
67MP0002933_joint_inflammation0.88673322
68MP0001984_abnormal_olfaction0.87364500
69MP0008058_abnormal_DNA_repair0.86748899
70MP0001968_abnormal_touch/_nociception0.86386088
71MP0002405_respiratory_system_inflammati0.82749056
72MP0005503_abnormal_tendon_morphology0.81740919
73MP0001845_abnormal_inflammatory_respons0.81692682
74MP0003693_abnormal_embryo_hatching0.81543420
75MP0001293_anophthalmia0.80700915
76MP0009046_muscle_twitch0.80533328
77MP0002452_abnormal_antigen_presenting0.80411381
78MP0000716_abnormal_immune_system0.79960516
79MP0002876_abnormal_thyroid_physiology0.79953614
80MP0005381_digestive/alimentary_phenotyp0.79387817
81MP0004142_abnormal_muscle_tone0.78442864
82MP0004134_abnormal_chest_morphology0.78186795
83MP0002722_abnormal_immune_system0.77996045
84MP0002736_abnormal_nociception_after0.76825807
85MP0002138_abnormal_hepatobiliary_system0.76770608
86MP0003075_altered_response_to0.75771841
87MP0005171_absent_coat_pigmentation0.74532242
88MP0005253_abnormal_eye_physiology0.74086743
89MP0005389_reproductive_system_phenotype0.73464110
90MP0001542_abnormal_bone_strength0.72557154
91MP0008469_abnormal_protein_level0.72497591
92MP0002653_abnormal_ependyma_morphology0.71260245
93MP0002733_abnormal_thermal_nociception0.71136430
94MP0003195_calcinosis0.70464563
95MP0005408_hypopigmentation0.70331510
96MP0005423_abnormal_somatic_nervous0.70057507
97MP0005075_abnormal_melanosome_morpholog0.69933175
98MP0000049_abnormal_middle_ear0.69771047
99MP0008789_abnormal_olfactory_epithelium0.69104985
100MP0003137_abnormal_impulse_conducting0.68808971

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune thrombocytopenia (HP:0001973)7.96505348
2Autoimmune hemolytic anemia (HP:0001890)6.90438798
3Increased IgM level (HP:0003496)6.87481285
4Abnormality of T cell number (HP:0011839)6.13222713
5Abnormal delayed hypersensitivity skin test (HP:0002963)5.76471070
6Abnormal activity of mitochondrial respiratory chain (HP:0011922)5.07500195
7Decreased activity of mitochondrial respiratory chain (HP:0008972)5.07500195
8Birth length less than 3rd percentile (HP:0003561)4.64011510
9Eosinophilia (HP:0001880)4.43245846
10Abnormality of eosinophils (HP:0001879)3.92906991
11Hypochromic anemia (HP:0001931)3.78222496
12Anterior segment dysgenesis (HP:0007700)3.63044767
13Neonatal hypoglycemia (HP:0001998)3.57222313
14Aplastic anemia (HP:0001915)3.53803049
15Acute necrotizing encephalopathy (HP:0006965)3.51457776
16Abnormality of T cells (HP:0002843)3.45740383
17Lip pit (HP:0100267)3.42743086
18Mitochondrial inheritance (HP:0001427)3.38265587
19Granulocytopenia (HP:0001913)3.37720803
20Increased hepatocellular lipid droplets (HP:0006565)3.32192787
21Glucose intolerance (HP:0000833)3.31522674
22Enlarged epiphyses (HP:0010580)3.27819879
23T lymphocytopenia (HP:0005403)3.27723969
24Myotonia (HP:0002486)3.22938781
25Congenital, generalized hypertrichosis (HP:0004540)3.21814917
26Abnormality of T cell physiology (HP:0011840)3.12933780
27Depressed nasal tip (HP:0000437)3.12391238
28Chin dimple (HP:0010751)3.12212071
29Abnormal mitochondria in muscle tissue (HP:0008316)3.11675061
30Renal Fanconi syndrome (HP:0001994)2.92769387
31Progressive macrocephaly (HP:0004481)2.89400634
32Agammaglobulinemia (HP:0004432)2.89305481
33Increased CSF lactate (HP:0002490)2.84041204
34Acute encephalopathy (HP:0006846)2.80570742
35Leukocytosis (HP:0001974)2.79132051
36Lipid accumulation in hepatocytes (HP:0006561)2.68938347
37IgG deficiency (HP:0004315)2.62217452
38Increased intramyocellular lipid droplets (HP:0012240)2.61157822
39Reticulocytopenia (HP:0001896)2.52719501
40Hepatocellular necrosis (HP:0001404)2.50486380
41Epileptic encephalopathy (HP:0200134)2.46457253
42Neutropenia (HP:0001875)2.43950900
43Sparse lateral eyebrow (HP:0005338)2.42803115
44Abnormality of cells of the lymphoid lineage (HP:0012140)2.40983599
45Stomatitis (HP:0010280)2.39230696
46Hypoproteinemia (HP:0003075)2.36275136
47Cerebral edema (HP:0002181)2.34674117
48Exertional dyspnea (HP:0002875)2.31756312
49Insulin-resistant diabetes mellitus (HP:0000831)2.29526894
50Abnormality of the neuromuscular junction (HP:0003398)2.24734968
51Fatigable weakness (HP:0003473)2.24734968
52Abnormal glucose tolerance (HP:0001952)2.24076869
53Hypergammaglobulinemia (HP:0010702)2.22588188
54Hepatic necrosis (HP:0002605)2.22402355
55Type 2 muscle fiber atrophy (HP:0003554)2.19014007
56Hypoalbuminemia (HP:0003073)2.14578971
57Abnormal albumin level (HP:0012116)2.14578971
58Severe combined immunodeficiency (HP:0004430)2.10003442
59Abnormal number of erythroid precursors (HP:0012131)2.07858486
60B lymphocytopenia (HP:0010976)2.06540945
61Generalized aminoaciduria (HP:0002909)2.01775628
62Constricted visual fields (HP:0001133)1.98929169
63Abnormality of cells of the erythroid lineage (HP:0012130)1.98305512
64Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.97989448
65Respiratory failure (HP:0002878)1.95607964
66Increased muscle lipid content (HP:0009058)1.95367804
67Macrocytic anemia (HP:0001972)1.95325458
68Vasculitis (HP:0002633)1.94327317
69Hypothermia (HP:0002045)1.92247008
70Abnormality of B cell number (HP:0010975)1.89843681
71Humeroradial synostosis (HP:0003041)1.89647808
72Synostosis involving the elbow (HP:0003938)1.89647808
73Symphalangism affecting the phalanges of the hand (HP:0009773)1.89144238
74Urticaria (HP:0001025)1.87499315
75Meningitis (HP:0001287)1.87332365
76Pancreatic cysts (HP:0001737)1.86700106
77Premature skin wrinkling (HP:0100678)1.86599264
78Partial duplication of thumb phalanx (HP:0009944)1.85999430
79Lactic acidosis (HP:0003128)1.84856179
80Hyperphosphaturia (HP:0003109)1.84534916
81Absent rod-and cone-mediated responses on ERG (HP:0007688)1.84516352
82Lethargy (HP:0001254)1.84416907
83Muscle fiber atrophy (HP:0100295)1.84372736
84Partial duplication of the phalanx of hand (HP:0009999)1.82378390
85Congenital stationary night blindness (HP:0007642)1.82317108
86Abnormality of renal resorption (HP:0011038)1.81576805
87Thyroiditis (HP:0100646)1.80123694
88Abnormality of midbrain morphology (HP:0002418)1.80071234
89Molar tooth sign on MRI (HP:0002419)1.80071234
903-Methylglutaconic aciduria (HP:0003535)1.78705377
91Abnormality of the columella (HP:0009929)1.77676688
92Abnormality of the prostate (HP:0008775)1.77634155
93Abnormality of the phalanges of the 2nd finger (HP:0009541)1.77305884
94Septo-optic dysplasia (HP:0100842)1.75202114
95Decreased central vision (HP:0007663)1.69352703
96Abnormality of the renal collecting system (HP:0004742)1.68958663
97Combined immunodeficiency (HP:0005387)1.68848540
98Methylmalonic acidemia (HP:0002912)1.67969143
99Hyperglycemia (HP:0003074)1.67888148
100Rectal fistula (HP:0100590)1.67347609

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK17.77684569
2PIK3CA6.10228662
3KDR3.26272905
4CDK193.12605030
5VRK22.83983417
6TXK2.65092661
7BCKDK2.54000350
8TESK22.39254885
9MUSK2.11909863
10KIT2.00522096
11BUB11.91609643
12TAOK31.80109265
13GRK71.73308292
14CAMKK21.64876262
15ZAK1.59996858
16TESK11.59791100
17MAP3K61.54972561
18OXSR11.47438932
19MAP4K11.41429077
20ADRBK21.35593578
21ITK1.32192111
22BMPR21.28928002
23TNK21.27659729
24VRK11.27517327
25NUAK11.27298119
26MAP2K61.20994220
27GRK61.14731089
28LIMK11.13408768
29CAMK1D1.10121270
30MAP4K21.09205316
31PRKCG1.08307051
32RET1.07215629
33GRK11.05966168
34SYK1.00335120
35TGFBR20.98784808
36WNK30.97845161
37INSRR0.97306896
38FES0.96621004
39PRKCQ0.95891229
40LCK0.90585073
41CSK0.82320111
42TAF10.78890777
43MAPK120.76454379
44MOS0.76143620
45GRK50.72809237
46PINK10.72291058
47NME10.70266072
48MAP2K70.70219383
49CAMK1G0.64241125
50ADRBK10.62641555
51INSR0.60504934
52PASK0.59520782
53MINK10.56011862
54TYRO30.55989312
55PDGFRB0.55839275
56MAPKAPK30.55354821
57ZAP700.52654887
58FRK0.51379183
59MAP2K40.51208592
60MARK30.50918645
61CAMKK10.49988342
62OBSCN0.49980543
63LYN0.49634375
64FYN0.49622507
65FGFR20.46195981
66JAK30.44407991
67CAMK10.44035393
68WNK40.43435916
69FGFR10.43277659
70BTK0.42888509
71AURKA0.42237605
72PAK10.42118589
73MAP3K120.41522026
74STK100.40472213
75MAP3K110.40221013
76EIF2AK30.39198940
77IGF1R0.36058300
78PRKACA0.35282092
79TEC0.35229930
80PRKCA0.34125871
81RPS6KA40.33717670
82BRSK10.33538993
83CSNK2A10.33406432
84CSNK1G30.33218539
85IKBKB0.32608810
86CSNK2A20.30719608
87MAP3K50.29058473
88MAP3K40.27427009
89MAP2K30.26171438
90CAMK2A0.26145453
91AURKB0.26123816
92STK110.25275688
93PLK40.25099649
94PRKG10.25010146
95PTK20.24714265
96TIE10.24252087
97MYLK0.24214491
98EIF2AK10.23190462
99CSNK1G10.22248202
100BRSK20.22074009

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.01469558
2Oxidative phosphorylation_Homo sapiens_hsa001903.99547525
3Graft-versus-host disease_Homo sapiens_hsa053323.88146168
4Allograft rejection_Homo sapiens_hsa053303.44567939
5Autoimmune thyroid disease_Homo sapiens_hsa053203.41452012
6Parkinsons disease_Homo sapiens_hsa050123.25505363
7Primary immunodeficiency_Homo sapiens_hsa053403.22164562
8Caffeine metabolism_Homo sapiens_hsa002323.08945110
9Proteasome_Homo sapiens_hsa030502.96135191
10Type I diabetes mellitus_Homo sapiens_hsa049402.87671915
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.76918465
12Protein export_Homo sapiens_hsa030602.64072218
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.57788152
14Alzheimers disease_Homo sapiens_hsa050102.32033807
15African trypanosomiasis_Homo sapiens_hsa051432.31172803
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.19511983
17Huntingtons disease_Homo sapiens_hsa050162.09744991
18RNA polymerase_Homo sapiens_hsa030201.98242911
19Cardiac muscle contraction_Homo sapiens_hsa042601.88327716
20Antigen processing and presentation_Homo sapiens_hsa046121.72126254
21Linoleic acid metabolism_Homo sapiens_hsa005911.65402894
22Rheumatoid arthritis_Homo sapiens_hsa053231.50643995
23Hematopoietic cell lineage_Homo sapiens_hsa046401.39767563
24Vitamin B6 metabolism_Homo sapiens_hsa007501.38716033
25T cell receptor signaling pathway_Homo sapiens_hsa046601.34725240
26Measles_Homo sapiens_hsa051621.33001217
27Malaria_Homo sapiens_hsa051441.30117640
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.21387227
29Homologous recombination_Homo sapiens_hsa034401.03954282
30Salmonella infection_Homo sapiens_hsa051321.01163254
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99094392
32Phototransduction_Homo sapiens_hsa047440.95269186
33Intestinal immune network for IgA production_Homo sapiens_hsa046720.95128250
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.94741760
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.94535484
36Nitrogen metabolism_Homo sapiens_hsa009100.92130690
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91352147
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88254755
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87594257
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.85774617
41Asthma_Homo sapiens_hsa053100.81636648
42Pentose phosphate pathway_Homo sapiens_hsa000300.71795792
43Spliceosome_Homo sapiens_hsa030400.64387517
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63197364
45NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62696219
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.62464632
47Fat digestion and absorption_Homo sapiens_hsa049750.61109781
48Systemic lupus erythematosus_Homo sapiens_hsa053220.59905406
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59818730
50Pyrimidine metabolism_Homo sapiens_hsa002400.58888843
51Taste transduction_Homo sapiens_hsa047420.58581380
52Chemical carcinogenesis_Homo sapiens_hsa052040.57194122
53Nucleotide excision repair_Homo sapiens_hsa034200.56673986
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.53096556
55Nicotine addiction_Homo sapiens_hsa050330.52276581
56Tryptophan metabolism_Homo sapiens_hsa003800.52250604
57Butanoate metabolism_Homo sapiens_hsa006500.49432582
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47710614
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.46997485
60Purine metabolism_Homo sapiens_hsa002300.46463339
61Retinol metabolism_Homo sapiens_hsa008300.46285210
62Toll-like receptor signaling pathway_Homo sapiens_hsa046200.46094047
63Fanconi anemia pathway_Homo sapiens_hsa034600.43879065
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43599122
65Influenza A_Homo sapiens_hsa051640.39630904
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38669141
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38257094
68One carbon pool by folate_Homo sapiens_hsa006700.37621782
69Arachidonic acid metabolism_Homo sapiens_hsa005900.37401182
70Mismatch repair_Homo sapiens_hsa034300.35913511
71RNA transport_Homo sapiens_hsa030130.35547892
72Collecting duct acid secretion_Homo sapiens_hsa049660.33132475
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32858095
74Viral myocarditis_Homo sapiens_hsa054160.32837897
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32044381
76Staphylococcus aureus infection_Homo sapiens_hsa051500.31240759
77Olfactory transduction_Homo sapiens_hsa047400.30503623
78DNA replication_Homo sapiens_hsa030300.30189655
79Basal transcription factors_Homo sapiens_hsa030220.30102342
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.29887945
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29759914
82Herpes simplex infection_Homo sapiens_hsa051680.29599322
83Apoptosis_Homo sapiens_hsa042100.27188787
84Ether lipid metabolism_Homo sapiens_hsa005650.25877806
85Metabolic pathways_Homo sapiens_hsa011000.23791626
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.20946957
87RNA degradation_Homo sapiens_hsa030180.20287075
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16111901
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.15951195
90Regulation of autophagy_Homo sapiens_hsa041400.15281725
91Chemokine signaling pathway_Homo sapiens_hsa040620.12735869
92cAMP signaling pathway_Homo sapiens_hsa040240.11098810
93Shigellosis_Homo sapiens_hsa051310.10637601
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.10313607
95Epstein-Barr virus infection_Homo sapiens_hsa051690.08952801
96HTLV-I infection_Homo sapiens_hsa051660.06070549
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.05792005
98Legionellosis_Homo sapiens_hsa051340.05255362
99Ras signaling pathway_Homo sapiens_hsa040140.04352930
100Folate biosynthesis_Homo sapiens_hsa007900.03788380

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