BOLA3P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.98452294
2translational termination (GO:0006415)7.70638270
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.57517300
4ATP synthesis coupled proton transport (GO:0015986)7.04686843
5energy coupled proton transport, down electrochemical gradient (GO:0015985)7.04686843
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.01875976
7cotranslational protein targeting to membrane (GO:0006613)6.92673956
8protein targeting to ER (GO:0045047)6.85435631
9establishment of protein localization to endoplasmic reticulum (GO:0072599)6.57912719
10protein localization to endoplasmic reticulum (GO:0070972)6.46456542
11ribosomal small subunit biogenesis (GO:0042274)6.34362861
12viral life cycle (GO:0019058)6.30898966
13translational elongation (GO:0006414)6.30445236
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.98117358
15cellular protein complex disassembly (GO:0043624)5.92784762
16protein complex biogenesis (GO:0070271)5.90791438
17viral protein processing (GO:0019082)5.82804203
18nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.69625489
19ribosomal small subunit assembly (GO:0000028)5.65141788
20respiratory electron transport chain (GO:0022904)5.56199870
21electron transport chain (GO:0022900)5.43293451
22mitochondrial respiratory chain complex assembly (GO:0033108)5.42306835
23ribosomal large subunit biogenesis (GO:0042273)5.38839674
24translational initiation (GO:0006413)5.37718461
25chaperone-mediated protein transport (GO:0072321)5.26188289
26regulation of mitochondrial translation (GO:0070129)5.22227087
27NADH dehydrogenase complex assembly (GO:0010257)5.02715354
28mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.02715354
29mitochondrial respiratory chain complex I assembly (GO:0032981)5.02715354
30cytochrome complex assembly (GO:0017004)4.99732512
31protein complex disassembly (GO:0043241)4.93418678
32protein targeting to membrane (GO:0006612)4.85559444
33macromolecular complex disassembly (GO:0032984)4.68748856
34regulation of DNA endoreduplication (GO:0032875)4.67669969
35translation (GO:0006412)4.66754021
36negative regulation of DNA-dependent DNA replication (GO:2000104)4.43883535
37establishment of protein localization to mitochondrial membrane (GO:0090151)4.32093934
38virion assembly (GO:0019068)4.20603664
39cellular component biogenesis (GO:0044085)4.16658985
40respiratory chain complex IV assembly (GO:0008535)4.14133357
41nonmotile primary cilium assembly (GO:0035058)4.13358980
42hydrogen ion transmembrane transport (GO:1902600)4.07062836
43nuclear-transcribed mRNA catabolic process (GO:0000956)4.01330215
44proteasome assembly (GO:0043248)3.97853578
45ATP biosynthetic process (GO:0006754)3.94430923
46ribonucleoprotein complex biogenesis (GO:0022613)3.89298054
47maturation of SSU-rRNA (GO:0030490)3.86435865
48mRNA catabolic process (GO:0006402)3.81906772
49purine nucleoside triphosphate biosynthetic process (GO:0009145)3.74283514
50purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.73977217
51proton transport (GO:0015992)3.56384579
52RNA catabolic process (GO:0006401)3.50609101
53protein neddylation (GO:0045116)3.48828183
54oxidative phosphorylation (GO:0006119)3.48021077
55purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.47779638
56hydrogen transport (GO:0006818)3.46968195
57retinal rod cell development (GO:0046548)3.44283358
58establishment of protein localization to membrane (GO:0090150)3.43791986
59spliceosomal complex assembly (GO:0000245)3.42882156
60protein targeting (GO:0006605)3.35333163
61RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.27698695
62tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.27698695
63purine deoxyribonucleotide catabolic process (GO:0009155)3.27363505
64ribonucleoside triphosphate biosynthetic process (GO:0009201)3.24978226
65DNA excision (GO:0044349)3.22813867
66nucleotide-excision repair, DNA damage removal (GO:0000718)3.22813867
67spermatid nucleus differentiation (GO:0007289)3.19074124
68nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.16688685
69GPI anchor biosynthetic process (GO:0006506)3.11888426
70GTP biosynthetic process (GO:0006183)3.09207146
71exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.08647084
72purine deoxyribonucleotide metabolic process (GO:0009151)3.05280718
73negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.01827340
74DNA deamination (GO:0045006)3.00581953
75regulation of cellular respiration (GO:0043457)2.95595351
76intra-S DNA damage checkpoint (GO:0031573)2.93837673
77negative regulation of appetite (GO:0032099)2.93236053
78negative regulation of response to food (GO:0032096)2.93236053
79positive regulation of vascular permeability (GO:0043117)2.93148039
80establishment of protein localization to organelle (GO:0072594)2.91585092
81pattern specification involved in kidney development (GO:0061004)2.90846322
82negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.84391478
83positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.79564002
84nucleoside triphosphate biosynthetic process (GO:0009142)2.78123400
85GPI anchor metabolic process (GO:0006505)2.75194135
86striatum development (GO:0021756)2.74895516
87protein localization to membrane (GO:0072657)2.72910527
88spliceosomal snRNP assembly (GO:0000387)2.69310066
89detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.68755019
90water-soluble vitamin biosynthetic process (GO:0042364)2.65931802
91negative regulation of T cell differentiation in thymus (GO:0033085)2.64606498
92protein targeting to mitochondrion (GO:0006626)2.63557368
93aldehyde catabolic process (GO:0046185)2.63074427
94regulation of cilium movement (GO:0003352)2.62774856
95mitochondrial transport (GO:0006839)2.61192580
96negative regulation of telomere maintenance (GO:0032205)2.59287612
97nucleoside diphosphate catabolic process (GO:0009134)2.57712399
98tRNA processing (GO:0008033)2.55795077
99UTP biosynthetic process (GO:0006228)2.55427001
100deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.55144390

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human5.40653588
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.84139403
3EZH2_22144423_ChIP-Seq_EOC_Human4.66459940
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.10735055
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.90658197
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.72855661
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.53768634
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.49862333
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.38714754
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.08476656
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.75849426
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.61929566
13VDR_22108803_ChIP-Seq_LS180_Human2.60205350
14ELK1_19687146_ChIP-ChIP_HELA_Human2.57933650
15VDR_23849224_ChIP-Seq_CD4+_Human2.50163441
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.39737944
17TTF2_22483619_ChIP-Seq_HELA_Human2.26468718
18FOXP3_21729870_ChIP-Seq_TREG_Human2.18167510
19CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.17417815
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.16897194
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.14680251
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.09246937
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.08001978
24SRF_21415370_ChIP-Seq_HL-1_Mouse1.95375594
25TAF15_26573619_Chip-Seq_HEK293_Human1.93654276
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.90624067
27XRN2_22483619_ChIP-Seq_HELA_Human1.80128742
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76962790
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.73139513
30GABP_19822575_ChIP-Seq_HepG2_Human1.72960116
31DCP1A_22483619_ChIP-Seq_HELA_Human1.70969228
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.68364567
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68213355
34CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.65873798
35ELK1_22589737_ChIP-Seq_MCF10A_Human1.60788627
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60680250
37EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.60398046
38MYC_19030024_ChIP-ChIP_MESCs_Mouse1.59123900
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.59054131
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57975842
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55155167
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53412591
43SRY_22984422_ChIP-ChIP_TESTIS_Rat1.51024886
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46086496
45MYC_18940864_ChIP-ChIP_HL60_Human1.45260668
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41051903
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.37501060
48FUS_26573619_Chip-Seq_HEK293_Human1.36575556
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35978905
50IRF1_19129219_ChIP-ChIP_H3396_Human1.30831922
51ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.29273637
52IGF1R_20145208_ChIP-Seq_DFB_Human1.26975902
53TP53_22573176_ChIP-Seq_HFKS_Human1.21810851
54EWS_26573619_Chip-Seq_HEK293_Human1.19730528
55SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.19283321
56THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15070727
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12501064
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12307264
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11411484
60KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10682811
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.10131967
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07224677
63PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.06484824
64PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.06129831
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04777635
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04570843
67CTCF_18555785_ChIP-Seq_MESCs_Mouse1.04149540
68ERG_20517297_ChIP-Seq_VCAP_Human1.00718710
69NELFA_20434984_ChIP-Seq_ESCs_Mouse1.00706998
70RNF2_27304074_Chip-Seq_NSC_Mouse1.00032892
71NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.97378934
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97260789
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95802572
74NANOG_18555785_ChIP-Seq_MESCs_Mouse0.92809284
75MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.89972321
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87767939
77FOXA1_27270436_Chip-Seq_PROSTATE_Human0.84986073
78FOXA1_25329375_ChIP-Seq_VCAP_Human0.84986073
79HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84918981
80YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.84802083
81E2F1_21310950_ChIP-Seq_MCF-7_Human0.83766181
82AR_20517297_ChIP-Seq_VCAP_Human0.83688252
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.83172376
84CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82854464
85SOX2_19829295_ChIP-Seq_ESCs_Human0.82558099
86NANOG_19829295_ChIP-Seq_ESCs_Human0.82558099
87FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.82336731
88FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80489497
89ERG_20887958_ChIP-Seq_HPC-7_Mouse0.80451968
90SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.79692414
91KDM5A_27292631_Chip-Seq_BREAST_Human0.79615647
92POU3F2_20337985_ChIP-ChIP_501MEL_Human0.79199563
93HTT_18923047_ChIP-ChIP_STHdh_Human0.78743851
94FOXA1_21572438_ChIP-Seq_LNCaP_Human0.77831346
95KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.77452277
96BMI1_23680149_ChIP-Seq_NPCS_Mouse0.77221386
97RUNX1_26923725_Chip-Seq_HPCs_Mouse0.75418830
98FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.74592881
99HOXB4_20404135_ChIP-ChIP_EML_Mouse0.72866918
100PCGF2_27294783_Chip-Seq_ESCs_Mouse0.72531175

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color6.49477484
2MP0009379_abnormal_foot_pigmentation5.38856158
3MP0002638_abnormal_pupillary_reflex3.87904741
4MP0004142_abnormal_muscle_tone3.50590515
5MP0000569_abnormal_digit_pigmentation3.32413653
6MP0003806_abnormal_nucleotide_metabolis3.30099433
7MP0001984_abnormal_olfaction3.08604855
8MP0002653_abnormal_ependyma_morphology2.84681282
9MP0003186_abnormal_redox_activity2.70129064
10MP0001764_abnormal_homeostasis2.41137559
11MP0002938_white_spotting2.34338481
12MP0001529_abnormal_vocalization2.08890679
13MP0008789_abnormal_olfactory_epithelium2.02946189
14MP0009046_muscle_twitch1.91989906
15MP0002095_abnormal_skin_pigmentation1.89163250
16MP0006072_abnormal_retinal_apoptosis1.87984026
17MP0002837_dystrophic_cardiac_calcinosis1.81466575
18MP0003122_maternal_imprinting1.75931358
19MP0005394_taste/olfaction_phenotype1.74886758
20MP0005499_abnormal_olfactory_system1.74886758
21MP0000631_abnormal_neuroendocrine_gland1.71712326
22MP0005174_abnormal_tail_pigmentation1.71382253
23MP0001485_abnormal_pinna_reflex1.70392399
24MP0001919_abnormal_reproductive_system1.64215967
25MP0002282_abnormal_trachea_morphology1.60679892
26MP0002163_abnormal_gland_morphology1.56563566
27MP0005646_abnormal_pituitary_gland1.54469903
28MP0002277_abnormal_respiratory_mucosa1.53724026
29MP0005253_abnormal_eye_physiology1.53074205
30MP0005551_abnormal_eye_electrophysiolog1.52943467
31MP0003011_delayed_dark_adaptation1.49302028
32MP0002160_abnormal_reproductive_system1.42356083
33MP0001502_abnormal_circadian_rhythm1.39623116
34MP0006036_abnormal_mitochondrial_physio1.34853026
35MP0005645_abnormal_hypothalamus_physiol1.33423204
36MP0002090_abnormal_vision1.32835584
37MP0003121_genomic_imprinting1.30943967
38MP0005389_reproductive_system_phenotype1.29743994
39MP0004145_abnormal_muscle_electrophysio1.26244378
40MP0008995_early_reproductive_senescence1.25380957
41MP0000026_abnormal_inner_ear1.22304308
42MP0004133_heterotaxia1.20889826
43MP0002132_abnormal_respiratory_system1.12704048
44MP0005377_hearing/vestibular/ear_phenot1.11959359
45MP0003878_abnormal_ear_physiology1.11959359
46MP0006276_abnormal_autonomic_nervous1.11717377
47MP0001324_abnormal_eye_pigmentation1.09344111
48MP0002572_abnormal_emotion/affect_behav1.04085642
49MP0005195_abnormal_posterior_eye1.00339156
50MP0002272_abnormal_nervous_system1.00112013
51MP0001440_abnormal_grooming_behavior0.99016960
52MP0001970_abnormal_pain_threshold0.95766123
53MP0002067_abnormal_sensory_capabilities0.93808614
54MP0000778_abnormal_nervous_system0.93344063
55MP0002557_abnormal_social/conspecific_i0.90271957
56MP0004885_abnormal_endolymph0.88655388
57MP0005075_abnormal_melanosome_morpholog0.88101875
58MP0002064_seizures0.87641129
59MP0005084_abnormal_gallbladder_morpholo0.87226087
60MP0002876_abnormal_thyroid_physiology0.86866244
61MP0009745_abnormal_behavioral_response0.85988594
62MP0001963_abnormal_hearing_physiology0.83949808
63MP0008872_abnormal_physiological_respon0.82630866
64MP0000955_abnormal_spinal_cord0.82113996
65MP0001486_abnormal_startle_reflex0.81522861
66MP0000647_abnormal_sebaceous_gland0.81521456
67MP0001293_anophthalmia0.81435154
68MP0009384_cardiac_valve_regurgitation0.81301037
69MP0005391_vision/eye_phenotype0.81226313
70MP0004859_abnormal_synaptic_plasticity0.80516337
71MP0005408_hypopigmentation0.80326068
72MP0000015_abnormal_ear_pigmentation0.80013047
73MP0002734_abnormal_mechanical_nocicepti0.79937932
74MP0001286_abnormal_eye_development0.78750196
75MP0002234_abnormal_pharynx_morphology0.78409930
76MP0006292_abnormal_olfactory_placode0.75242739
77MP0008877_abnormal_DNA_methylation0.74733637
78MP0000343_altered_response_to0.73996016
79MP0003567_abnormal_fetal_cardiomyocyte0.73304849
80MP0008058_abnormal_DNA_repair0.72477221
81MP0002752_abnormal_somatic_nervous0.71992622
82MP0002736_abnormal_nociception_after0.71731902
83MP0001905_abnormal_dopamine_level0.71382730
84MP0003950_abnormal_plasma_membrane0.69690152
85MP0005535_abnormal_body_temperature0.68806972
86MP0001881_abnormal_mammary_gland0.68601237
87MP0002102_abnormal_ear_morphology0.67942602
88MP0000685_abnormal_immune_system0.66901248
89MP0001765_abnormal_ion_homeostasis0.66317669
90MP0000371_diluted_coat_color0.64996744
91MP0005266_abnormal_metabolism0.63989766
92MP0000750_abnormal_muscle_regeneration0.63454987
93MP0005319_abnormal_enzyme/_coenzyme0.63222139
94MP0009764_decreased_sensitivity_to0.62715057
95MP0005636_abnormal_mineral_homeostasis0.58636882
96MP0002733_abnormal_thermal_nociception0.56595107
97MP0008875_abnormal_xenobiotic_pharmacok0.56523334
98MP0005376_homeostasis/metabolism_phenot0.55812135
99MP0005448_abnormal_energy_balance0.55004538
100MP0000230_abnormal_systemic_arterial0.54386820

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.53693928
2Mitochondrial inheritance (HP:0001427)5.14446455
3Septo-optic dysplasia (HP:0100842)4.99494300
4Hepatocellular necrosis (HP:0001404)4.95766119
5Reticulocytopenia (HP:0001896)4.85225034
6Abnormal mitochondria in muscle tissue (HP:0008316)4.84149746
7Increased hepatocellular lipid droplets (HP:0006565)4.70859892
8Lipid accumulation in hepatocytes (HP:0006561)4.67005563
9Increased CSF lactate (HP:0002490)4.59404708
10Acute encephalopathy (HP:0006846)4.56279946
11Progressive macrocephaly (HP:0004481)4.54022756
12Hepatic necrosis (HP:0002605)4.11086464
13Renal Fanconi syndrome (HP:0001994)4.02109344
14Abnormality of cells of the erythroid lineage (HP:0012130)3.61653919
15Exertional dyspnea (HP:0002875)3.55948274
16Microretrognathia (HP:0000308)3.53774054
17Increased intramyocellular lipid droplets (HP:0012240)3.48440544
18Macrocytic anemia (HP:0001972)3.38551592
19Cerebral edema (HP:0002181)3.34094933
203-Methylglutaconic aciduria (HP:0003535)3.27042646
21Absent septum pellucidum (HP:0001331)3.21973128
22Gait imbalance (HP:0002141)3.17927295
23Abnormality of DNA repair (HP:0003254)3.16198636
24Increased muscle lipid content (HP:0009058)3.14226793
25Nephrogenic diabetes insipidus (HP:0009806)3.13942767
26Medial flaring of the eyebrow (HP:0010747)3.13876299
27Myokymia (HP:0002411)3.01812723
28Congenital primary aphakia (HP:0007707)3.01281203
29Molar tooth sign on MRI (HP:0002419)2.96116500
30Abnormality of midbrain morphology (HP:0002418)2.96116500
31Abnormality of renal resorption (HP:0011038)2.95995304
32Respiratory failure (HP:0002878)2.90526623
33Congenital, generalized hypertrichosis (HP:0004540)2.89274054
34Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.80275573
35Respiratory difficulties (HP:0002880)2.78505753
36Increased serum lactate (HP:0002151)2.70997780
37Leukodystrophy (HP:0002415)2.69866629
38Abnormality of the septum pellucidum (HP:0007375)2.68003933
39Exercise intolerance (HP:0003546)2.66318825
40Optic disc pallor (HP:0000543)2.65869232
41Lactic acidosis (HP:0003128)2.54678334
42Maternal diabetes (HP:0009800)2.51014518
43Nephronophthisis (HP:0000090)2.50955093
44Pallor (HP:0000980)2.50725486
45Partial duplication of thumb phalanx (HP:0009944)2.43390393
46Absent thumb (HP:0009777)2.43271105
47Constricted visual fields (HP:0001133)2.39490674
48Short 1st metacarpal (HP:0010034)2.38877603
49Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.38877603
50Abnormal number of erythroid precursors (HP:0012131)2.36877048
51Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.34193098
52Pancreatic cysts (HP:0001737)2.34027224
53Cortical visual impairment (HP:0100704)2.32591915
54Optic nerve hypoplasia (HP:0000609)2.32169616
55CNS demyelination (HP:0007305)2.28957167
56Aplasia/Hypoplasia of the uvula (HP:0010293)2.28342824
57Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.27764428
58Decreased activity of mitochondrial respiratory chain (HP:0008972)2.27764428
59Diastasis recti (HP:0001540)2.25254643
60Abnormality of the renal medulla (HP:0100957)2.23965301
61Myotonia (HP:0002486)2.22650700
62Vaginal atresia (HP:0000148)2.22306015
63Genital tract atresia (HP:0001827)2.20135736
64Meckel diverticulum (HP:0002245)2.17307280
65Type I transferrin isoform profile (HP:0003642)2.12861718
66Abnormality of the 1st metacarpal (HP:0010009)2.12350638
67Poor coordination (HP:0002370)2.11453745
68Emotional lability (HP:0000712)2.10799614
69Abnormality of the ileum (HP:0001549)2.07041573
70Stenosis of the external auditory canal (HP:0000402)2.05555905
71Flat capital femoral epiphysis (HP:0003370)2.04246785
72Lethargy (HP:0001254)2.04231120
73Rib fusion (HP:0000902)2.02602652
74Duplication of thumb phalanx (HP:0009942)1.99957949
75Renal tubular dysfunction (HP:0000124)1.99742010
76Squamous cell carcinoma (HP:0002860)1.98294056
77Poor head control (HP:0002421)1.97287027
78Partial duplication of the phalanx of hand (HP:0009999)1.97286866
79Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.94669307
80Pancreatic fibrosis (HP:0100732)1.91392285
81Glycosuria (HP:0003076)1.90713198
82Abnormality of urine glucose concentration (HP:0011016)1.90713198
83Progressive microcephaly (HP:0000253)1.90297078
84Abnormality of the pons (HP:0007361)1.89076051
85Hyperphosphaturia (HP:0003109)1.87284274
86Abnormality of chromosome stability (HP:0003220)1.86012298
87Abnormal rod and cone electroretinograms (HP:0008323)1.85688296
88Abnormality of the renal collecting system (HP:0004742)1.84568906
89Gliosis (HP:0002171)1.82030034
90Microvesicular hepatic steatosis (HP:0001414)1.80625884
91Delayed CNS myelination (HP:0002188)1.80543743
92Sclerocornea (HP:0000647)1.79826755
93Duplicated collecting system (HP:0000081)1.79579401
94Chromsome breakage (HP:0040012)1.79537270
95Hypoplasia of the pons (HP:0012110)1.78321313
96X-linked dominant inheritance (HP:0001423)1.73849783
97Specific learning disability (HP:0001328)1.73035769
98Blindness (HP:0000618)1.72081654
99Bony spicule pigmentary retinopathy (HP:0007737)1.70466085
100Short femoral neck (HP:0100864)1.70125736

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K75.13305553
2PRKD33.90491877
3MAP3K123.51985954
4ARAF3.37465494
5ZAK3.19935137
6NEK92.69672919
7TNK22.65520607
8STK162.63028548
9BCKDK2.18292077
10NTRK22.15147190
11VRK21.89648302
12NME21.72014674
13MARK31.66358363
14WNK41.63612335
15VRK11.61461737
16FRK1.61420743
17PNCK1.47078771
18NEK11.46218132
19CDK191.45364147
20SRPK11.43243256
21PIK3CG1.42739397
22PHKG11.34502736
23PHKG21.34502736
24NTRK31.34394482
25MAP3K91.33606430
26NME11.33579088
27MAPK131.33205508
28TAOK31.29981721
29NUAK11.25552396
30DYRK21.23396896
31MAP3K131.22857073
32MYLK1.12853600
33KIT1.02802292
34PIM11.02661241
35MOS1.02489856
36CSNK1G31.01822955
37CDC71.01199179
38PASK1.00811829
39PLK10.97774173
40WNK30.96891677
41EIF2AK10.94854165
42AURKA0.92135379
43TLK10.90732225
44CASK0.89977449
45EIF2AK20.89932089
46BRAF0.89127530
47AURKB0.86841494
48INSRR0.82250440
49CSNK2A20.81861124
50MAP3K10.81770862
51WEE10.79815575
52MARK10.77987617
53CSNK1A10.77486245
54MAP3K40.76875244
55CSNK1G20.74003264
56TSSK60.71814231
57MAP3K110.70767194
58MAP2K40.68725807
59DAPK30.68438546
60BMPR1B0.68088437
61CSNK1G10.66551737
62PRKCG0.66220232
63KSR10.65687026
64BMPR20.63341905
65ERBB20.62355939
66ILK0.62257414
67RPS6KA60.59532807
68MINK10.59245844
69MAPK150.58087937
70ABL20.57888445
71CHEK20.56839958
72GRK10.55146503
73NLK0.55046307
74OBSCN0.54654307
75MAPKAPK30.54464569
76PLK30.52631848
77PAK40.51751002
78CSNK1E0.49359989
79SIK20.49290813
80RPS6KC10.48790548
81RPS6KL10.48790548
82PRKCI0.48689748
83RPS6KA50.48673662
84STK110.46540964
85CSNK2A10.46495117
86SCYL20.45081002
87TTK0.44165964
88PINK10.44089356
89STK380.43243367
90EIF2AK30.42686354
91PRKACA0.40589568
92PRKCE0.40528281
93RPS6KB20.39762792
94TIE10.39214678
95FGFR10.39008677
96EPHA40.38728170
97UHMK10.38194728
98ADRBK20.38003162
99PIM20.37743524
100STK38L0.36403786

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.31983487
2Oxidative phosphorylation_Homo sapiens_hsa001905.47841585
3Parkinsons disease_Homo sapiens_hsa050124.48145785
4Protein export_Homo sapiens_hsa030603.79256048
5Proteasome_Homo sapiens_hsa030503.26725417
6Alzheimers disease_Homo sapiens_hsa050103.23348132
7Huntingtons disease_Homo sapiens_hsa050163.12217722
8Cardiac muscle contraction_Homo sapiens_hsa042602.64004491
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.63259284
10Homologous recombination_Homo sapiens_hsa034402.47392556
11Asthma_Homo sapiens_hsa053102.10228702
12Nucleotide excision repair_Homo sapiens_hsa034201.96315191
13Fanconi anemia pathway_Homo sapiens_hsa034601.90637451
14RNA polymerase_Homo sapiens_hsa030201.79699677
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.76144106
16Folate biosynthesis_Homo sapiens_hsa007901.74602716
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.62050528
18RNA degradation_Homo sapiens_hsa030181.46667962
19Sulfur relay system_Homo sapiens_hsa041221.45655010
20Mismatch repair_Homo sapiens_hsa034301.43538355
21DNA replication_Homo sapiens_hsa030301.35338121
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.23429372
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.16006925
24Type I diabetes mellitus_Homo sapiens_hsa049401.13503398
25Spliceosome_Homo sapiens_hsa030401.11364810
26Allograft rejection_Homo sapiens_hsa053301.06906227
27Basal transcription factors_Homo sapiens_hsa030221.04988713
28One carbon pool by folate_Homo sapiens_hsa006701.00861972
29Autoimmune thyroid disease_Homo sapiens_hsa053201.00250613
30Pyrimidine metabolism_Homo sapiens_hsa002400.98210182
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95411218
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87438740
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84362020
34Systemic lupus erythematosus_Homo sapiens_hsa053220.79117595
35Steroid hormone biosynthesis_Homo sapiens_hsa001400.78929676
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78194420
37Chemical carcinogenesis_Homo sapiens_hsa052040.78054722
38Graft-versus-host disease_Homo sapiens_hsa053320.75260459
39RNA transport_Homo sapiens_hsa030130.72856370
40Metabolic pathways_Homo sapiens_hsa011000.70337832
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69513196
42Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68753839
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67480332
44Nicotine addiction_Homo sapiens_hsa050330.65925660
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65273258
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63787799
47Nitrogen metabolism_Homo sapiens_hsa009100.62132702
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59563563
49Purine metabolism_Homo sapiens_hsa002300.58755718
50Glutathione metabolism_Homo sapiens_hsa004800.58412088
51Propanoate metabolism_Homo sapiens_hsa006400.57605320
52Collecting duct acid secretion_Homo sapiens_hsa049660.57409490
53Phototransduction_Homo sapiens_hsa047440.56721136
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54581047
55Linoleic acid metabolism_Homo sapiens_hsa005910.51878494
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.49687778
57Rheumatoid arthritis_Homo sapiens_hsa053230.49291663
58beta-Alanine metabolism_Homo sapiens_hsa004100.49023531
59Tryptophan metabolism_Homo sapiens_hsa003800.48780121
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47060367
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46998843
62GABAergic synapse_Homo sapiens_hsa047270.46590123
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46028144
64Tyrosine metabolism_Homo sapiens_hsa003500.45177705
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44474851
66Wnt signaling pathway_Homo sapiens_hsa043100.42766368
67Retinol metabolism_Homo sapiens_hsa008300.42660387
68Butanoate metabolism_Homo sapiens_hsa006500.41853205
69Fatty acid degradation_Homo sapiens_hsa000710.41070004
70Peroxisome_Homo sapiens_hsa041460.40586738
71Alcoholism_Homo sapiens_hsa050340.39796018
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.39621465
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36549463
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.34513922
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33767229
76Morphine addiction_Homo sapiens_hsa050320.33329875
77Caffeine metabolism_Homo sapiens_hsa002320.32779188
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32178347
79Phenylalanine metabolism_Homo sapiens_hsa003600.31376645
80Mineral absorption_Homo sapiens_hsa049780.30770400
81Cell cycle_Homo sapiens_hsa041100.29646031
82Non-homologous end-joining_Homo sapiens_hsa034500.28898353
83Regulation of autophagy_Homo sapiens_hsa041400.28509081
84Circadian rhythm_Homo sapiens_hsa047100.27821569
85Base excision repair_Homo sapiens_hsa034100.27443002
86Fatty acid elongation_Homo sapiens_hsa000620.26934595
87Cocaine addiction_Homo sapiens_hsa050300.25862797
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.25816177
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25550059
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.25329105
91Serotonergic synapse_Homo sapiens_hsa047260.24774631
92Taste transduction_Homo sapiens_hsa047420.24480633
93Steroid biosynthesis_Homo sapiens_hsa001000.23963863
94Arachidonic acid metabolism_Homo sapiens_hsa005900.22479366
95Basal cell carcinoma_Homo sapiens_hsa052170.19089224
96Antigen processing and presentation_Homo sapiens_hsa046120.18656308
97Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.17916515
98Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.14795500
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.14793786
100Vitamin digestion and absorption_Homo sapiens_hsa049770.14184081

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