BORA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: BORA is an activator of the protein kinase Aurora A (AURKA; MIM 603072), which is required for centrosome maturation, spindle assembly, and asymmetric protein localization during mitosis (Hutterer et al., 2006 [PubMed 16890155]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA ligation (GO:0006266)5.52121928
2protein localization to kinetochore (GO:0034501)5.25559460
3mitotic metaphase plate congression (GO:0007080)5.01976798
4kinetochore organization (GO:0051383)4.80298367
5protein localization to chromosome, centromeric region (GO:0071459)4.73870528
6CENP-A containing nucleosome assembly (GO:0034080)4.71854901
7DNA strand elongation involved in DNA replication (GO:0006271)4.63370776
8chromatin remodeling at centromere (GO:0031055)4.61612200
9metaphase plate congression (GO:0051310)4.51057672
10ribosomal small subunit assembly (GO:0000028)4.46494264
11telomere maintenance via semi-conservative replication (GO:0032201)4.46017189
12DNA strand elongation (GO:0022616)4.43756006
13DNA unwinding involved in DNA replication (GO:0006268)4.42095259
14DNA replication initiation (GO:0006270)4.42002381
15mitotic sister chromatid segregation (GO:0000070)4.41874307
16attachment of spindle microtubules to kinetochore (GO:0008608)4.36898533
17mitotic chromosome condensation (GO:0007076)4.28471963
18DNA replication-independent nucleosome assembly (GO:0006336)4.27790941
19DNA replication-independent nucleosome organization (GO:0034724)4.27790941
20kinetochore assembly (GO:0051382)4.25227434
21establishment of integrated proviral latency (GO:0075713)4.22160034
22maturation of SSU-rRNA (GO:0030490)4.19653168
23sister chromatid segregation (GO:0000819)4.10741568
24telomere maintenance via recombination (GO:0000722)4.09948402
25DNA replication checkpoint (GO:0000076)4.09920999
26establishment of chromosome localization (GO:0051303)4.09515014
27regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.07673746
28mitotic nuclear envelope disassembly (GO:0007077)4.07050254
29mitotic recombination (GO:0006312)4.04871646
30DNA double-strand break processing (GO:0000729)4.00274276
31DNA packaging (GO:0006323)3.95168539
32meiotic chromosome segregation (GO:0045132)3.94720661
33microtubule depolymerization (GO:0007019)3.92962635
34* regulation of spindle organization (GO:0090224)3.90536057
35nucleobase biosynthetic process (GO:0046112)3.89597266
36histone exchange (GO:0043486)3.87378741
37pore complex assembly (GO:0046931)3.78927509
38positive regulation of chromosome segregation (GO:0051984)3.76337837
39nuclear envelope disassembly (GO:0051081)3.73503686
40membrane disassembly (GO:0030397)3.73503686
41viral transcription (GO:0019083)3.68532875
42telomere maintenance via telomere lengthening (GO:0010833)3.66889215
43DNA replication-dependent nucleosome assembly (GO:0006335)3.64922296
44DNA replication-dependent nucleosome organization (GO:0034723)3.64922296
45negative regulation of mitosis (GO:0045839)3.63855604
46translational termination (GO:0006415)3.63380167
47anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.62822285
48spindle checkpoint (GO:0031577)3.59442386
49purine nucleobase biosynthetic process (GO:0009113)3.58227881
50DNA deamination (GO:0045006)3.56533800
51regulation of centriole replication (GO:0046599)3.56248053
52replication fork processing (GO:0031297)3.54287332
53mitotic G2/M transition checkpoint (GO:0044818)3.52327550
54nuclear pore organization (GO:0006999)3.51468816
55regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.48951204
56protein localization to chromosome (GO:0034502)3.47986905
57regulation of chromosome segregation (GO:0051983)3.47198551
58spindle assembly checkpoint (GO:0071173)3.46338969
59nucleotide-excision repair, DNA gap filling (GO:0006297)3.45925545
60ribosomal small subunit biogenesis (GO:0042274)3.45718137
61nuclear pore complex assembly (GO:0051292)3.45274997
62formation of translation preinitiation complex (GO:0001731)3.44916734
63regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.42654275
64negative regulation of chromosome segregation (GO:0051985)3.42137402
65regulation of sister chromatid cohesion (GO:0007063)3.40718752
66negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.40247535
67negative regulation of sister chromatid segregation (GO:0033046)3.40247535
68negative regulation of mitotic sister chromatid separation (GO:2000816)3.40247535
69negative regulation of mitotic sister chromatid segregation (GO:0033048)3.40247535
70ribosomal large subunit biogenesis (GO:0042273)3.40238883
71DNA topological change (GO:0006265)3.38354131
72IMP biosynthetic process (GO:0006188)3.37513471
73chromosome segregation (GO:0007059)3.37034909
74establishment of viral latency (GO:0019043)3.35958564
75mitotic spindle assembly checkpoint (GO:0007094)3.35736337
76regulation of mitotic metaphase/anaphase transition (GO:0030071)3.35222562
77negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.33345914
78translational elongation (GO:0006414)3.33175260
79double-strand break repair via nonhomologous end joining (GO:0006303)3.31992926
80non-recombinational repair (GO:0000726)3.31992926
81histone-serine phosphorylation (GO:0035404)3.31392688
82positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.30486566
83positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.30486566
84positive regulation of mitotic sister chromatid separation (GO:1901970)3.30486566
85mitotic spindle checkpoint (GO:0071174)3.30343566
86chromatin assembly or disassembly (GO:0006333)3.30227272
87regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.30003695
88ribonucleoprotein complex biogenesis (GO:0022613)3.28807002
89negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)3.25629902
90* mitotic cell cycle (GO:0000278)3.23079104
91translational initiation (GO:0006413)3.22740008
92ribosome biogenesis (GO:0042254)3.21833235
93negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.21673731
94DNA catabolic process, exonucleolytic (GO:0000738)3.19218664
95regulation of sister chromatid segregation (GO:0033045)3.18838337
96regulation of mitotic sister chromatid separation (GO:0010965)3.18838337
97regulation of mitotic sister chromatid segregation (GO:0033047)3.18838337
98negative regulation of cell division (GO:0051782)3.18600139
99nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.17408751
100ventricular cardiac muscle cell development (GO:0055015)3.16686963
101negative regulation of nuclear division (GO:0051784)3.16652624
102protein K6-linked ubiquitination (GO:0085020)3.15918852
103regulation of nuclear cell cycle DNA replication (GO:0033262)3.15536266
104rRNA processing (GO:0006364)3.15081398
105regulation of mitotic spindle checkpoint (GO:1903504)3.14797404
106regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.14797404
107spliceosomal snRNP assembly (GO:0000387)3.13953432
108regulation of centrosome cycle (GO:0046605)3.13341010
109maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.13326110
110heterochromatin organization (GO:0070828)3.12634831
111SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.11629376
112positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.11566932
113V(D)J recombination (GO:0033151)3.11532080
114mitotic G2 DNA damage checkpoint (GO:0007095)3.11141163
115nuclear envelope organization (GO:0006998)3.10493306
116ATP-dependent chromatin remodeling (GO:0043044)3.09255146
117regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.09093387
118regulation of double-strand break repair via homologous recombination (GO:0010569)3.08366014
119rRNA modification (GO:0000154)3.07433422
120IMP metabolic process (GO:0046040)3.06971546
121DNA duplex unwinding (GO:0032508)3.06712575
122DNA geometric change (GO:0032392)3.06172030
123cotranslational protein targeting to membrane (GO:0006613)3.05086816
124rRNA metabolic process (GO:0016072)3.04947384
125ribosome assembly (GO:0042255)3.02372435
126protein targeting to ER (GO:0045047)3.01181330
127mitotic sister chromatid cohesion (GO:0007064)3.00214039
128chromosome condensation (GO:0030261)2.98252310
129* regulation of mitotic spindle organization (GO:0060236)2.98155078
130transcription-coupled nucleotide-excision repair (GO:0006283)2.97431390
131telomere organization (GO:0032200)2.96809914
132telomere maintenance (GO:0000723)2.96806718
133folic acid-containing compound biosynthetic process (GO:0009396)2.94289623
134DNA conformation change (GO:0071103)2.94065807

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.91254054
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.59125971
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.28073657
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.15231802
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.83508514
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.43582213
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.20121077
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.87708053
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.80845541
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.74952045
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.70732121
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.62678480
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.60015235
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.57779599
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.48688214
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.48389128
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.42790293
18AR_21909140_ChIP-Seq_LNCAP_Human2.40880109
19XRN2_22483619_ChIP-Seq_HELA_Human2.28817681
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28556019
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.19607449
22VDR_23849224_ChIP-Seq_CD4+_Human2.18902410
23E2F1_21310950_ChIP-Seq_MCF-7_Human2.11740098
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.09066683
25FOXP3_21729870_ChIP-Seq_TREG_Human2.00230878
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.98511322
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.92574980
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.90203640
29DCP1A_22483619_ChIP-Seq_HELA_Human1.88469067
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88144739
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.87093775
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82929842
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.82020350
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81228233
35TTF2_22483619_ChIP-Seq_HELA_Human1.80218286
36KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.80146920
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76932196
38GABP_19822575_ChIP-Seq_HepG2_Human1.76015699
39CIITA_25753668_ChIP-Seq_RAJI_Human1.73412411
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72495399
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70070395
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66487009
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.66363150
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.64538511
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63492449
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62166631
47ELK1_19687146_ChIP-ChIP_HELA_Human1.62009944
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60700207
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.57007720
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56812117
51MYC_22102868_ChIP-Seq_BL_Human1.55822990
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45343530
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.43154023
54KDM5A_27292631_Chip-Seq_BREAST_Human1.42609325
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40765730
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37311816
57TP63_19390658_ChIP-ChIP_HaCaT_Human1.35935166
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35468178
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34540179
60ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33765395
61SRF_21415370_ChIP-Seq_HL-1_Mouse1.32372998
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27447747
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26833688
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24627701
65E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24417794
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17650376
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15242629
68PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.15024619
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.14029540
70VDR_21846776_ChIP-Seq_THP-1_Human1.11271877
71KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09476359
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08840822
73SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03958980
74MYC_18940864_ChIP-ChIP_HL60_Human1.03664075
75SPI1_23547873_ChIP-Seq_NB4_Human1.01771868
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.01211679
77TFEB_21752829_ChIP-Seq_HELA_Human1.00035056
78STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99832864
79SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.99610974
80DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99224849
81CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99185543
82EWS_26573619_Chip-Seq_HEK293_Human0.98676709
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98123730
84ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96519957
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96073987
86KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94951524
87SOX2_16153702_ChIP-ChIP_HESCs_Human0.91355994
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90080696
89NANOG_16153702_ChIP-ChIP_HESCs_Human0.87743737
90CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87218247
91POU5F1_16153702_ChIP-ChIP_HESCs_Human0.86729331
92BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86635712
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.86575005
94HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.85801200
95SOX17_20123909_ChIP-Seq_XEN_Mouse0.83010621
96NANOG_21062744_ChIP-ChIP_HESCs_Human0.82105514
97TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.81412184
98SCL_19346495_ChIP-Seq_HPC-7_Human0.81345378
99CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.78895317
100CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.76776080
101FUS_26573619_Chip-Seq_HEK293_Human0.76773906
102MYB_21317192_ChIP-Seq_ERMYB_Mouse0.76529217
103TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76082915
104IRF1_19129219_ChIP-ChIP_H3396_Human0.74773419
105KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.74663279
106MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.72900399
107ELK1_22589737_ChIP-Seq_MCF10A_Human0.71713938
108SALL1_21062744_ChIP-ChIP_HESCs_Human0.71576622
109FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70502685
110SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.67043204
111IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.65479546
112HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.63604338
113CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.60082745
114CHD1_26751641_Chip-Seq_LNCaP_Human0.57868148
115NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.56980523

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.73945478
2MP0010094_abnormal_chromosome_stability5.00752931
3MP0003111_abnormal_nucleus_morphology4.98953117
4MP0004957_abnormal_blastocyst_morpholog4.30639651
5MP0003077_abnormal_cell_cycle4.24478473
6MP0008057_abnormal_DNA_replication4.05732231
7MP0008058_abnormal_DNA_repair3.36962086
8MP0008007_abnormal_cellular_replicative3.11452966
9MP0002396_abnormal_hematopoietic_system2.99796739
10MP0009697_abnormal_copulation2.62909912
11MP0008932_abnormal_embryonic_tissue2.57682379
12MP0003123_paternal_imprinting2.25871607
13MP0001730_embryonic_growth_arrest2.21191270
14MP0000350_abnormal_cell_proliferation2.16517872
15MP0008877_abnormal_DNA_methylation1.99315311
16MP0003786_premature_aging1.97742038
17MP0004808_abnormal_hematopoietic_stem1.89321561
18MP0000490_abnormal_crypts_of1.82686065
19MP0010307_abnormal_tumor_latency1.71463583
20MP0001697_abnormal_embryo_size1.68505495
21MP0005380_embryogenesis_phenotype1.67314086
22MP0001672_abnormal_embryogenesis/_devel1.67314086
23MP0001727_abnormal_embryo_implantation1.66711294
24MP0001545_abnormal_hematopoietic_system1.64743973
25MP0005397_hematopoietic_system_phenotyp1.64743973
26MP0010352_gastrointestinal_tract_polyps1.61702926
27MP0006035_abnormal_mitochondrial_morpho1.54532684
28MP0002080_prenatal_lethality1.54382812
29MP0003718_maternal_effect1.54326039
30MP0000313_abnormal_cell_death1.50786587
31MP0003984_embryonic_growth_retardation1.49614133
32MP0002019_abnormal_tumor_incidence1.48261575
33MP0003121_genomic_imprinting1.46234696
34MP0002085_abnormal_embryonic_tissue1.45158940
35MP0002088_abnormal_embryonic_growth/wei1.44901901
36MP0006292_abnormal_olfactory_placode1.41136389
37MP0006054_spinal_hemorrhage1.39809886
38MP0002086_abnormal_extraembryonic_tissu1.36024900
39MP0003567_abnormal_fetal_cardiomyocyte1.28320823
40MP0002084_abnormal_developmental_patter1.27940201
41MP0002210_abnormal_sex_determination1.27615245
42MP0001346_abnormal_lacrimal_gland1.25858091
43MP0003763_abnormal_thymus_physiology1.24846332
44MP0002398_abnormal_bone_marrow1.24039205
45MP0004197_abnormal_fetal_growth/weight/1.20500763
46MP0009333_abnormal_splenocyte_physiolog1.19742667
47MP0000703_abnormal_thymus_morphology1.19591941
48MP0001293_anophthalmia1.19397390
49MP0001145_abnormal_male_reproductive1.14435254
50MP0002722_abnormal_immune_system1.12725064
51MP0001929_abnormal_gametogenesis1.12625384
52MP0010030_abnormal_orbit_morphology1.12370115
53MP0000689_abnormal_spleen_morphology1.07543418
54MP0001529_abnormal_vocalization1.02576506
55MP0000653_abnormal_sex_gland1.00727458
56MP0005075_abnormal_melanosome_morpholog0.99673366
57MP0005395_other_phenotype0.99082969
58MP0002095_abnormal_skin_pigmentation0.97283811
59MP0008789_abnormal_olfactory_epithelium0.95978508
60MP0005174_abnormal_tail_pigmentation0.95155869
61MP0002429_abnormal_blood_cell0.94451137
62MP0002697_abnormal_eye_size0.92791285
63MP0006036_abnormal_mitochondrial_physio0.92538917
64MP0003315_abnormal_perineum_morphology0.92065825
65MP0002132_abnormal_respiratory_system0.91917696
66MP0009278_abnormal_bone_marrow0.91692052
67MP0004147_increased_porphyrin_level0.90884744
68MP0003941_abnormal_skin_development0.89136860
69MP0006072_abnormal_retinal_apoptosis0.87818135
70MP0003890_abnormal_embryonic-extraembry0.87447036
71MP0001119_abnormal_female_reproductive0.84691923
72MP0000465_gastrointestinal_hemorrhage0.84454631
73MP0002938_white_spotting0.82962895
74MP0002009_preneoplasia0.81431850
75MP0000428_abnormal_craniofacial_morphol0.81152710
76MP0000716_abnormal_immune_system0.80893633
77MP0000858_altered_metastatic_potential0.78914971
78MP0002877_abnormal_melanocyte_morpholog0.77712535
79MP0001919_abnormal_reproductive_system0.77021087
80MP0003937_abnormal_limbs/digits/tail_de0.76435430
81MP0000537_abnormal_urethra_morphology0.76393920
82MP0009672_abnormal_birth_weight0.75647261
83MP0009053_abnormal_anal_canal0.75034520
84MP0005076_abnormal_cell_differentiation0.74467351
85MP0002233_abnormal_nose_morphology0.73935047
86MP0001915_intracranial_hemorrhage0.73156669
87MP0009379_abnormal_foot_pigmentation0.72088345
88MP0002111_abnormal_tail_morphology0.71975196
89MP0005384_cellular_phenotype0.71175304
90MP0002102_abnormal_ear_morphology0.71153327
91MP0002161_abnormal_fertility/fecundity0.68117871
92MP0002163_abnormal_gland_morphology0.67374445
93MP0005621_abnormal_cell_physiology0.66735158
94MP0003861_abnormal_nervous_system0.65010965
95MP0008995_early_reproductive_senescence0.63627734
96MP0002420_abnormal_adaptive_immunity0.62609962
97MP0000015_abnormal_ear_pigmentation0.62364733
98MP0000477_abnormal_intestine_morphology0.62174451
99MP0003221_abnormal_cardiomyocyte_apopto0.62089687
100MP0003186_abnormal_redox_activity0.61356334
101MP0003943_abnormal_hepatobiliary_system0.61202748
102MP0001819_abnormal_immune_cell0.60556497
103MP0000049_abnormal_middle_ear0.60059171
104MP0003119_abnormal_digestive_system0.59898222
105MP0009703_decreased_birth_body0.59831581
106MP0000358_abnormal_cell_content/0.59719436
107MP0001286_abnormal_eye_development0.59358525
108MP0002092_abnormal_eye_morphology0.59272690
109MP0005391_vision/eye_phenotype0.58542009
110MP0004264_abnormal_extraembryonic_tissu0.58443109
111MP0003806_abnormal_nucleotide_metabolis0.58249873
112MP0005389_reproductive_system_phenotype0.57746237
113MP0003656_abnormal_erythrocyte_physiolo0.57578611
114MP0005248_abnormal_Harderian_gland0.57451842
115MP0002160_abnormal_reproductive_system0.57048833
116MP0001800_abnormal_humoral_immune0.56790116
117MP0005394_taste/olfaction_phenotype0.56747882
118MP0005499_abnormal_olfactory_system0.56747882
119MP0000627_abnormal_mammary_gland0.55972776
120MP0002075_abnormal_coat/hair_pigmentati0.55608640
121MP0003755_abnormal_palate_morphology0.55485823
122MP0000566_synostosis0.55375926
123MP0002932_abnormal_joint_morphology0.54088687
124MP0002452_abnormal_antigen_presenting0.53850917
125MP0003699_abnormal_female_reproductive0.53273880
126MP0003698_abnormal_male_reproductive0.53238947
127MP0000432_abnormal_head_morphology0.52125082
128MP0005023_abnormal_wound_healing0.52108805
129MP0001853_heart_inflammation0.51814185
130MP0003936_abnormal_reproductive_system0.51796229
131MP0005408_hypopigmentation0.51135630

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.82685239
2Birth length less than 3rd percentile (HP:0003561)4.63661803
3Chromsome breakage (HP:0040012)4.56435600
4Abnormality of cells of the erythroid lineage (HP:0012130)4.40464796
5Abnormal number of erythroid precursors (HP:0012131)4.35584489
6Chromosomal breakage induced by crosslinking agents (HP:0003221)4.25848635
7Cortical dysplasia (HP:0002539)3.99038050
8Aplastic anemia (HP:0001915)3.89624269
9Breast hypoplasia (HP:0003187)3.67516332
10Abnormality of chromosome stability (HP:0003220)3.50334657
11Patellar aplasia (HP:0006443)3.40411754
12Carpal bone hypoplasia (HP:0001498)3.31980854
13Colon cancer (HP:0003003)3.31444222
14Myelodysplasia (HP:0002863)3.29735863
15Meckel diverticulum (HP:0002245)3.28243836
16Abnormality of the preputium (HP:0100587)3.24667690
17Oral leukoplakia (HP:0002745)3.23042340
18Aplasia/Hypoplasia of the patella (HP:0006498)3.16304223
19Abnormality of the ileum (HP:0001549)3.13616343
20Aplasia/Hypoplasia of the uvula (HP:0010293)3.04500786
21Small intestinal stenosis (HP:0012848)3.04324056
22Duodenal stenosis (HP:0100867)3.04324056
23Medulloblastoma (HP:0002885)3.02115518
2411 pairs of ribs (HP:0000878)2.91160601
25Selective tooth agenesis (HP:0001592)2.90007132
26Pallor (HP:0000980)2.84189695
27Impulsivity (HP:0100710)2.83946566
28Macrocytic anemia (HP:0001972)2.76062979
29Thrombocytosis (HP:0001894)2.75977175
30Bone marrow hypocellularity (HP:0005528)2.72348594
31Degeneration of anterior horn cells (HP:0002398)2.72021711
32Abnormality of the anterior horn cell (HP:0006802)2.72021711
33Rough bone trabeculation (HP:0100670)2.67482054
34Absent thumb (HP:0009777)2.66047601
35Abnormal lung lobation (HP:0002101)2.65686537
36Sloping forehead (HP:0000340)2.63774420
37Hypoplasia of the capital femoral epiphysis (HP:0003090)2.57482915
38Microvesicular hepatic steatosis (HP:0001414)2.54311022
39Duplicated collecting system (HP:0000081)2.49975031
40Abnormality of the duodenum (HP:0002246)2.46140816
41Ectopic kidney (HP:0000086)2.46120963
42Nephroblastoma (Wilms tumor) (HP:0002667)2.44558495
43Absent radius (HP:0003974)2.40169506
44Abnormality of DNA repair (HP:0003254)2.37206317
45Premature graying of hair (HP:0002216)2.31777475
46Increased nuchal translucency (HP:0010880)2.31513822
47Agnosia (HP:0010524)2.30709436
48Abnormal number of incisors (HP:0011064)2.30482392
49Volvulus (HP:0002580)2.28652480
50Supernumerary spleens (HP:0009799)2.25810966
51Embryonal renal neoplasm (HP:0011794)2.25114431
52Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.24275266
53Abnormal foot bone ossification (HP:0010675)2.22858543
54Abnormality of the renal collecting system (HP:0004742)2.22043240
55Embryonal neoplasm (HP:0002898)2.22027390
56Ependymoma (HP:0002888)2.21280459
57Irregular epiphyses (HP:0010582)2.21194024
58Abnormality of the carotid arteries (HP:0005344)2.21127992
59Aplasia involving forearm bones (HP:0009822)2.19969856
60Absent forearm bone (HP:0003953)2.19969856
61Hypoplasia of the pons (HP:0012110)2.19458998
62Abnormality of the heme biosynthetic pathway (HP:0010472)2.19233583
63Microretrognathia (HP:0000308)2.19110165
64Horseshoe kidney (HP:0000085)2.17425239
65Triphalangeal thumb (HP:0001199)2.16734088
66Cerebral hypomyelination (HP:0006808)2.15723605
67Abnormality of the pons (HP:0007361)2.13740127
68Abnormality of chromosome segregation (HP:0002916)2.12637953
69Rhabdomyosarcoma (HP:0002859)2.12595780
70Neoplasm of the pancreas (HP:0002894)2.10054958
71Tracheoesophageal fistula (HP:0002575)2.09565138
72Basal cell carcinoma (HP:0002671)2.06517369
73Multiple enchondromatosis (HP:0005701)2.05732480
74Absent epiphyses (HP:0010577)2.04656088
75Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.04656088
76Short thumb (HP:0009778)2.04569735
77Clubbing of toes (HP:0100760)2.04258581
78Acute myeloid leukemia (HP:0004808)2.03196745
79Pancytopenia (HP:0001876)2.02252973
80Lymphoma (HP:0002665)2.01935621
81Facial hemangioma (HP:0000329)2.01449068
82Atresia of the external auditory canal (HP:0000413)2.00622191
83Aplasia/Hypoplasia of the sacrum (HP:0008517)1.99350520
84Acute encephalopathy (HP:0006846)1.98562359
85Prominent nose (HP:0000448)1.97113560
86Type I transferrin isoform profile (HP:0003642)1.96287377
87Cafe-au-lait spot (HP:0000957)1.95433520
88Abnormal tarsal ossification (HP:0008369)1.94087688
89Progressive external ophthalmoplegia (HP:0000590)1.94056333
90Squamous cell carcinoma (HP:0002860)1.93622639
91Abnormality of reticulocytes (HP:0004312)1.92271280
92Acute necrotizing encephalopathy (HP:0006965)1.90794556
93Cellular immunodeficiency (HP:0005374)1.90344353
94Proximal placement of thumb (HP:0009623)1.90143827
95Abnormality of the labia minora (HP:0012880)1.89180865
96Choanal atresia (HP:0000453)1.88934563
97Abnormal trabecular bone morphology (HP:0100671)1.86886722
98High pitched voice (HP:0001620)1.86782599
99Deviation of the thumb (HP:0009603)1.82978434
100IgM deficiency (HP:0002850)1.82630482
101Cleft eyelid (HP:0000625)1.82513265
102Short 4th metacarpal (HP:0010044)1.81812740
103Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.81812740
104Glioma (HP:0009733)1.81588246
105Neoplasm of the colon (HP:0100273)1.81070580
106Arteriovenous malformation (HP:0100026)1.79828326
107Short middle phalanx of the 5th finger (HP:0004220)1.79313847
108Acute lymphatic leukemia (HP:0006721)1.79141334
109Missing ribs (HP:0000921)1.79130346
110Amaurosis fugax (HP:0100576)1.78436012
111Poikiloderma (HP:0001029)1.76861747
112Ovarian neoplasm (HP:0100615)1.76111921
113Aplasia/Hypoplasia of the sternum (HP:0006714)1.75735796
114Abnormal mitochondria in muscle tissue (HP:0008316)1.74934147
115Optic nerve coloboma (HP:0000588)1.74456761
116Pancreatic islet-cell hyperplasia (HP:0004510)1.74424508
117Premature ovarian failure (HP:0008209)1.73380326
118Increased hepatocellular lipid droplets (HP:0006565)1.72522546
119Abnormality of methionine metabolism (HP:0010901)1.72101925
120Reduced antithrombin III activity (HP:0001976)1.70723322
121Overlapping toe (HP:0001845)1.69958274
122Hypoplastic pelvis (HP:0008839)1.69414355
123Deep philtrum (HP:0002002)1.67024715
124Neoplasm of striated muscle (HP:0009728)1.66889922
125Limb hypertonia (HP:0002509)1.65917438
126Malignant gastrointestinal tract tumors (HP:0006749)1.65303736
127Gastrointestinal carcinoma (HP:0002672)1.65303736
128Cerebral edema (HP:0002181)1.64621334
129Abnormality of the proximal phalanges of the hand (HP:0009834)1.63275708
130Uterine neoplasm (HP:0010784)1.61908832
131Combined immunodeficiency (HP:0005387)1.60501788
132Hyperinsulinemic hypoglycemia (HP:0000825)1.58065609

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.22255916
2WEE14.56392253
3CDC73.94195724
4NEK23.30066351
5BRSK22.78623548
6EIF2AK12.67726519
7TTK2.66347606
8SRPK12.51071594
9VRK22.42389680
10PLK42.28926170
11STK162.25837975
12* PLK12.17374567
13MKNK12.13487557
14BRSK12.10080421
15PNCK2.00828836
16VRK11.98443989
17BRD41.95438862
18ACVR1B1.93362031
19AURKB1.89742150
20TSSK61.86933909
21MKNK21.84350798
22NME21.83559507
23CCNB11.79105205
24NEK11.78830257
25TAF11.76071231
26STK101.70120405
27CDK71.68574539
28TNIK1.65304132
29* ATR1.61501549
30PLK31.61156445
31DYRK31.57150465
32RPS6KB21.56566672
33CHEK21.51983528
34TLK11.47178297
35EIF2AK31.44944276
36RPS6KA41.42101175
37MAP3K81.40221623
38EEF2K1.36444540
39TESK21.35835724
40PASK1.35665492
41STK41.31043847
42CDK41.30993626
43CDK121.28245958
44AURKA1.27385648
45NME11.24220699
46CHEK11.19006819
47CDK81.18699731
48MST41.07263033
49MELK1.07139560
50ZAK1.00905761
51TGFBR10.99864888
52SMG10.97954959
53TRIM280.96796647
54PAK40.96380647
55ATM0.90175804
56CDK20.80523873
57MAP4K10.80239184
58PIM10.77535773
59EIF2AK20.75253236
60FLT30.74797170
61STK30.72743616
62TEC0.72113583
63CLK10.69253522
64PIM20.66041749
65LRRK20.65236942
66MAP3K100.65167737
67KDR0.65151446
68NLK0.63596789
69CDK60.63193364
70* CDK10.63158374
71BTK0.62665210
72PAK10.61109799
73CSNK2A10.59994162
74CSNK2A20.59643634
75SCYL20.58335829
76BRAF0.57489593
77KIT0.53950698
78WNK30.49182070
79MAPKAPK30.46922251
80RPS6KA50.44952997
81CDK90.44362707
82MAP2K30.43273710
83ALK0.41071699
84CDK30.38326715
85MST1R0.37783440
86BMPR1B0.35275193
87TESK10.35151830
88NEK90.35043504
89EPHA20.34706368
90NUAK10.34342631
91TAOK20.32914564
92MAP3K110.32743178
93MAPK110.32223994
94PRKCI0.30544553
95PLK20.29524009
96CSF1R0.29321927
97STK240.28478363
98LATS10.28075594
99PBK0.27275019
100AKT20.26961740
101PRKDC0.25006808
102MAP3K90.24684355
103CSNK1G30.24156249
104CDK180.22749966
105RAF10.21821435
106ERBB30.21311486
107ILK0.21253165
108CDK150.21099842
109MAPK140.21027189
110ERBB40.20990178
111CDK11A0.20558007
112LYN0.20498457
113MAPKAPK20.20170141
114JAK30.19975755
115CSNK1E0.19906607
116RPS6KB10.19682112
117MAP3K40.19451151
118BCR0.18557543
119IRAK40.18539394
120AKT10.18116222
121MTOR0.16382613
122MARK30.15210942
123PKN20.14950980
124FGFR10.14667990
125MAPK10.14581118
126ZAP700.14388272
127CDK140.14005569
128CSNK1G10.13280631
129UHMK10.11817573
130STK38L0.09644783
131LATS20.06832550
132PDK20.04987037

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.06906270
2Mismatch repair_Homo sapiens_hsa034304.31785019
3Ribosome_Homo sapiens_hsa030103.53127504
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.41363920
5Homologous recombination_Homo sapiens_hsa034403.37272821
6Spliceosome_Homo sapiens_hsa030403.32894787
7Base excision repair_Homo sapiens_hsa034103.28169144
8RNA polymerase_Homo sapiens_hsa030203.24967159
9Cell cycle_Homo sapiens_hsa041103.13989327
10RNA transport_Homo sapiens_hsa030133.03805155
11Nucleotide excision repair_Homo sapiens_hsa034202.90875871
12Fanconi anemia pathway_Homo sapiens_hsa034602.60983905
13Proteasome_Homo sapiens_hsa030502.51128995
14Pyrimidine metabolism_Homo sapiens_hsa002402.47000820
15One carbon pool by folate_Homo sapiens_hsa006702.29220912
16Non-homologous end-joining_Homo sapiens_hsa034502.28416625
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.18278311
18Basal transcription factors_Homo sapiens_hsa030222.05349292
19RNA degradation_Homo sapiens_hsa030182.03805956
20mRNA surveillance pathway_Homo sapiens_hsa030151.75857894
21p53 signaling pathway_Homo sapiens_hsa041151.70261545
22Purine metabolism_Homo sapiens_hsa002301.33688132
23Systemic lupus erythematosus_Homo sapiens_hsa053221.20279427
24Oocyte meiosis_Homo sapiens_hsa041141.19120577
25Epstein-Barr virus infection_Homo sapiens_hsa051691.17378338
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15594739
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.09614443
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08748093
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08695996
30Pyruvate metabolism_Homo sapiens_hsa006201.05298882
31Herpes simplex infection_Homo sapiens_hsa051681.02253731
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95201203
33Propanoate metabolism_Homo sapiens_hsa006400.95106565
34Viral carcinogenesis_Homo sapiens_hsa052030.92766894
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91118182
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91052622
37Pentose phosphate pathway_Homo sapiens_hsa000300.90628768
38Protein export_Homo sapiens_hsa030600.87950677
39Antigen processing and presentation_Homo sapiens_hsa046120.86366625
40Vitamin B6 metabolism_Homo sapiens_hsa007500.80366603
41Oxidative phosphorylation_Homo sapiens_hsa001900.79714579
42HTLV-I infection_Homo sapiens_hsa051660.77686831
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72019701
44Folate biosynthesis_Homo sapiens_hsa007900.71935699
45Steroid biosynthesis_Homo sapiens_hsa001000.70613240
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.69728990
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69115348
48Thyroid cancer_Homo sapiens_hsa052160.68991691
49MicroRNAs in cancer_Homo sapiens_hsa052060.68866861
50Small cell lung cancer_Homo sapiens_hsa052220.68799657
51Primary immunodeficiency_Homo sapiens_hsa053400.68237025
52Fatty acid elongation_Homo sapiens_hsa000620.65477882
53Selenocompound metabolism_Homo sapiens_hsa004500.65274040
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56547668
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54831558
56N-Glycan biosynthesis_Homo sapiens_hsa005100.54769135
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.53874532
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.53127856
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52773266
60Biosynthesis of amino acids_Homo sapiens_hsa012300.52572440
61Legionellosis_Homo sapiens_hsa051340.47352865
62Measles_Homo sapiens_hsa051620.46937474
63Hepatitis B_Homo sapiens_hsa051610.44239939
64Huntingtons disease_Homo sapiens_hsa050160.44190975
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43901534
66Sulfur relay system_Homo sapiens_hsa041220.43208838
67Glutathione metabolism_Homo sapiens_hsa004800.42963009
68Apoptosis_Homo sapiens_hsa042100.41724098
69Wnt signaling pathway_Homo sapiens_hsa043100.39419348
70Alzheimers disease_Homo sapiens_hsa050100.38336129
71Hematopoietic cell lineage_Homo sapiens_hsa046400.38324095
72Hedgehog signaling pathway_Homo sapiens_hsa043400.37956257
73Colorectal cancer_Homo sapiens_hsa052100.36724221
74Alcoholism_Homo sapiens_hsa050340.36190751
75Adherens junction_Homo sapiens_hsa045200.35291657
76Shigellosis_Homo sapiens_hsa051310.35289394
77TGF-beta signaling pathway_Homo sapiens_hsa043500.35015990
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34992885
79Chronic myeloid leukemia_Homo sapiens_hsa052200.34968528
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.34316993
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32813249
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32253456
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32052355
84Notch signaling pathway_Homo sapiens_hsa043300.31371307
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29513804
86Basal cell carcinoma_Homo sapiens_hsa052170.29053522
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28239003
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27352147
89Influenza A_Homo sapiens_hsa051640.27052134
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.26423706
91Galactose metabolism_Homo sapiens_hsa000520.24661287
92Hippo signaling pathway_Homo sapiens_hsa043900.23444385
93Pathways in cancer_Homo sapiens_hsa052000.23355475
94Intestinal immune network for IgA production_Homo sapiens_hsa046720.22345381
95Acute myeloid leukemia_Homo sapiens_hsa052210.20661418
96HIF-1 signaling pathway_Homo sapiens_hsa040660.19528620
97Carbon metabolism_Homo sapiens_hsa012000.19011178
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.17693723
99Non-small cell lung cancer_Homo sapiens_hsa052230.17620042
100Lysine degradation_Homo sapiens_hsa003100.17558947
101Fatty acid metabolism_Homo sapiens_hsa012120.17225137
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.17189335
103Peroxisome_Homo sapiens_hsa041460.17049950
104B cell receptor signaling pathway_Homo sapiens_hsa046620.16901666
105Parkinsons disease_Homo sapiens_hsa050120.15894945
106Metabolic pathways_Homo sapiens_hsa011000.15577408
107Arachidonic acid metabolism_Homo sapiens_hsa005900.15475671
108Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.15473341
109Asthma_Homo sapiens_hsa053100.14844854
110Fructose and mannose metabolism_Homo sapiens_hsa000510.14838458
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.14262226
112Pancreatic cancer_Homo sapiens_hsa052120.13979503
113Renin-angiotensin system_Homo sapiens_hsa046140.13738084
114Bladder cancer_Homo sapiens_hsa052190.12784601
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.12242063
116Prostate cancer_Homo sapiens_hsa052150.11072373
117Leishmaniasis_Homo sapiens_hsa051400.10956892
118FoxO signaling pathway_Homo sapiens_hsa040680.10651830
119Jak-STAT signaling pathway_Homo sapiens_hsa046300.09476062
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.09210757
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.08408778
122Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.07960176
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.04692932

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