BORCS5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)9.45934828
2transcription from mitochondrial promoter (GO:0006390)7.55846054
3DNA deamination (GO:0045006)7.45873477
4proline metabolic process (GO:0006560)7.13979552
5replication fork processing (GO:0031297)6.97844605
6positive regulation of protein homooligomerization (GO:0032464)6.28921252
7maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.85790729
8oxidative demethylation (GO:0070989)5.75799319
9regulation of protein homooligomerization (GO:0032462)5.75026457
10mitochondrial DNA metabolic process (GO:0032042)5.05876391
11embryonic process involved in female pregnancy (GO:0060136)4.92584872
12maturation of 5.8S rRNA (GO:0000460)4.87256005
13pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.85790208
14negative regulation of JAK-STAT cascade (GO:0046426)4.84567681
15behavioral response to nicotine (GO:0035095)4.82252708
16DNA strand renaturation (GO:0000733)4.60892822
17poly(A)+ mRNA export from nucleus (GO:0016973)4.51538259
18negative regulation of protein oligomerization (GO:0032460)4.50297300
19piRNA metabolic process (GO:0034587)4.45167644
20mitotic G1 DNA damage checkpoint (GO:0031571)4.44430984
21regulation of integrin activation (GO:0033623)4.43105339
22establishment of apical/basal cell polarity (GO:0035089)4.24331888
23pyrimidine nucleotide catabolic process (GO:0006244)4.22699213
24viral mRNA export from host cell nucleus (GO:0046784)4.15200024
25synaptic vesicle endocytosis (GO:0048488)4.12462511
26somatic hypermutation of immunoglobulin genes (GO:0016446)4.10639134
27somatic diversification of immune receptors via somatic mutation (GO:0002566)4.10639134
28protein deneddylation (GO:0000338)4.09475515
29establishment of protein localization to mitochondrial membrane (GO:0090151)4.07206241
30base-excision repair, AP site formation (GO:0006285)4.03442660
31DNA methylation involved in gamete generation (GO:0043046)4.02130074
32regulation of cAMP-dependent protein kinase activity (GO:2000479)3.99930077
33establishment or maintenance of monopolar cell polarity (GO:0061339)3.93445280
34establishment of monopolar cell polarity (GO:0061162)3.93445280
35G1 DNA damage checkpoint (GO:0044783)3.84949381
36negative regulation of Ras GTPase activity (GO:0034261)3.84769308
37mitotic G1/S transition checkpoint (GO:0044819)3.80411345
38GDP-mannose metabolic process (GO:0019673)3.78799704
39cullin deneddylation (GO:0010388)3.76803099
40L-fucose catabolic process (GO:0042355)3.75545923
41fucose catabolic process (GO:0019317)3.75545923
42L-fucose metabolic process (GO:0042354)3.75545923
43glutamine family amino acid biosynthetic process (GO:0009084)3.73621705
44mitochondrial RNA metabolic process (GO:0000959)3.64170336
45cellular response to ATP (GO:0071318)3.62043694
46regulation of protein oligomerization (GO:0032459)3.59108628
47sleep (GO:0030431)3.57817639
48non-recombinational repair (GO:0000726)3.52311742
49double-strand break repair via nonhomologous end joining (GO:0006303)3.52311742
50positive regulation of defense response to virus by host (GO:0002230)3.49496654
51protein K11-linked deubiquitination (GO:0035871)3.48283551
52neuromuscular process controlling posture (GO:0050884)3.47109717
53DNA integration (GO:0015074)3.46574952
54base-excision repair (GO:0006284)3.45573430
55regulation of early endosome to late endosome transport (GO:2000641)3.44538009
56negative regulation of fatty acid biosynthetic process (GO:0045717)3.42952962
57cellular response to interleukin-15 (GO:0071350)3.41655217
58negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.38222899
59telomere maintenance via semi-conservative replication (GO:0032201)3.34364464
60regulation of glomerular filtration (GO:0003093)3.34008162
61negative regulation of cell cycle arrest (GO:0071157)3.32842964
62retinal cone cell development (GO:0046549)3.31558719
63negative regulation of heart rate (GO:0010459)3.30613184
64respiratory system process (GO:0003016)3.28630223
65positive regulation of DNA repair (GO:0045739)3.28025478
66protein polyglutamylation (GO:0018095)3.27432780
67positive regulation of protein oligomerization (GO:0032461)3.25816044
68regulation of double-strand break repair via homologous recombination (GO:0010569)3.24638114
69synaptic vesicle exocytosis (GO:0016079)3.20252730
70meiotic chromosome segregation (GO:0045132)3.17723460
71mitochondrial fusion (GO:0008053)3.16893224
72glial cell migration (GO:0008347)3.16177513
73mitochondrial DNA replication (GO:0006264)3.14554785
74positive regulation of circadian rhythm (GO:0042753)3.13928258
75platelet dense granule organization (GO:0060155)3.12414089
76positive regulation of dendritic spine morphogenesis (GO:0061003)3.11409536
77negative regulation of telomere maintenance (GO:0032205)3.11234176
78inositol phosphate dephosphorylation (GO:0046855)3.10941012
79phosphorylated carbohydrate dephosphorylation (GO:0046838)3.10941012
80nucleotide-excision repair, DNA gap filling (GO:0006297)3.10708412
81preassembly of GPI anchor in ER membrane (GO:0016254)3.10487211
82detection of light stimulus involved in visual perception (GO:0050908)3.08791216
83detection of light stimulus involved in sensory perception (GO:0050962)3.08791216
84spliceosomal tri-snRNP complex assembly (GO:0000244)3.08700174
85multicellular organism reproduction (GO:0032504)3.07542518
86single strand break repair (GO:0000012)3.05246661
87rRNA catabolic process (GO:0016075)3.02363674
88negative regulation of interleukin-1 beta production (GO:0032691)3.02110856
89cell migration in hindbrain (GO:0021535)3.01085039
90establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.00714583
91mitochondrion transport along microtubule (GO:0047497)3.00714583
92DNA double-strand break processing (GO:0000729)3.00006726
93mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.99120988
94positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.99120988
95interferon-gamma production (GO:0032609)2.97796180
96formation of translation preinitiation complex (GO:0001731)2.95139836
97negative regulation of appetite (GO:0032099)2.95080772
98negative regulation of response to food (GO:0032096)2.95080772
99membrane tubulation (GO:0097320)2.94448965
100regulation of translational fidelity (GO:0006450)2.92569230
101regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.91833027
102heme biosynthetic process (GO:0006783)2.90947138
103regulation of membrane depolarization (GO:0003254)2.90836276
104positive regulation of mRNA catabolic process (GO:0061014)2.89678862
105SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)2.89402496
106positive regulation of TOR signaling (GO:0032008)2.88581333
107inositol phosphate catabolic process (GO:0071545)2.88391671
108regulation of sister chromatid cohesion (GO:0007063)2.88372851
109labyrinthine layer development (GO:0060711)2.87255408
110positive regulation of developmental pigmentation (GO:0048087)2.85788694
111regulation of mitochondrial depolarization (GO:0051900)2.85210130
112response to interleukin-15 (GO:0070672)2.83224580
113cellular response to zinc ion (GO:0071294)2.83070397
114negative T cell selection (GO:0043383)2.83050113
115histone H4-K12 acetylation (GO:0043983)2.81589492
116epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.79626655
117tolerance induction (GO:0002507)2.78819658
118embryonic placenta development (GO:0001892)2.78239493
119positive regulation of humoral immune response (GO:0002922)2.78096701
120signal complex assembly (GO:0007172)2.77622797
121resolution of meiotic recombination intermediates (GO:0000712)2.76510749
122detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.76250419
123establishment of mitochondrion localization (GO:0051654)2.75081088
124sulfur amino acid catabolic process (GO:0000098)2.74893303
125mannosylation (GO:0097502)2.74000201
126positive regulation of receptor recycling (GO:0001921)2.73508711
127negative regulation of interleukin-1 production (GO:0032692)2.72940098
128regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.72624772
129positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.71451325
130mRNA cleavage (GO:0006379)2.70957989
131mRNA polyadenylation (GO:0006378)2.69849084
132DNA demethylation (GO:0080111)2.69085305
133pyrimidine ribonucleoside catabolic process (GO:0046133)2.68309071
134ubiquinone biosynthetic process (GO:0006744)2.68017957
135metallo-sulfur cluster assembly (GO:0031163)2.65641241
136iron-sulfur cluster assembly (GO:0016226)2.65641241
137gamma-aminobutyric acid transport (GO:0015812)2.65471831
138cytidine deamination (GO:0009972)2.65207722
139cytidine metabolic process (GO:0046087)2.65207722
140cytidine catabolic process (GO:0006216)2.65207722
141renal system process involved in regulation of blood volume (GO:0001977)2.64800220
142regulation of defense response to virus by host (GO:0050691)2.64175525
143telomere maintenance via recombination (GO:0000722)2.63828316
144somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.63617710
145somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.63617710
146isotype switching (GO:0045190)2.63617710
147L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.63483683
148cellular ketone body metabolic process (GO:0046950)2.63093539
149establishment of protein localization to Golgi (GO:0072600)2.62982268
150regulation of isotype switching to IgG isotypes (GO:0048302)2.62622941
151positive regulation of natural killer cell mediated immunity (GO:0002717)2.62452739
152neural tube formation (GO:0001841)2.62076744
153positive regulation of prostaglandin secretion (GO:0032308)2.59266058
154cAMP catabolic process (GO:0006198)2.58890631
155negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.58565423
156negative regulation of translation, ncRNA-mediated (GO:0040033)2.58565423
157regulation of translation, ncRNA-mediated (GO:0045974)2.58565423
158activated T cell proliferation (GO:0050798)2.56359503
159axoneme assembly (GO:0035082)2.55769275
160GPI anchor metabolic process (GO:0006505)2.55314678
161negative thymic T cell selection (GO:0045060)2.55230702
162positive regulation of oligodendrocyte differentiation (GO:0048714)2.54480724
163positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.53965181
164regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.53965181
165adenosine metabolic process (GO:0046085)2.52967594
166C-terminal protein amino acid modification (GO:0018410)2.52579693
167pseudouridine synthesis (GO:0001522)2.51367544
168startle response (GO:0001964)2.49260044
169C-terminal protein lipidation (GO:0006501)2.48154734
170regulation of leukocyte mediated cytotoxicity (GO:0001910)2.46020730
171protein K63-linked deubiquitination (GO:0070536)2.45383607
172response to pheromone (GO:0019236)2.45027059
173ketone body metabolic process (GO:1902224)2.43178794
174male meiosis I (GO:0007141)2.43050436
175regulation of acrosome reaction (GO:0060046)2.42585005
176histone H2A ubiquitination (GO:0033522)2.42256522
177tRNA modification (GO:0006400)2.42129535
178regulation of neurotransmitter uptake (GO:0051580)2.41275789
179tRNA processing (GO:0008033)2.41090103
180negative regulation of organelle assembly (GO:1902116)2.40713162
181photoreceptor cell maintenance (GO:0045494)2.39671303
182positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.39443246
183positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.38887751
184L-methionine salvage (GO:0071267)2.38115710
185L-methionine biosynthetic process (GO:0071265)2.38115710
186amino acid salvage (GO:0043102)2.38115710
187DNA modification (GO:0006304)2.38017088
188ubiquinone metabolic process (GO:0006743)2.37309994
189nonmotile primary cilium assembly (GO:0035058)2.36765404
190regulation of microtubule-based movement (GO:0060632)2.36595759
191respiratory chain complex IV assembly (GO:0008535)2.36507840
192regulation of natural killer cell mediated immunity (GO:0002715)2.35964587
193regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.35964587
194protein targeting to Golgi (GO:0000042)2.35766269
195cornea development in camera-type eye (GO:0061303)2.35766201

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.51137652
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.24668187
3NOTCH1_21737748_ChIP-Seq_TLL_Human3.08019922
4EZH2_22144423_ChIP-Seq_EOC_Human2.92931575
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.79626747
6IGF1R_20145208_ChIP-Seq_DFB_Human2.74550396
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.64294835
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.54735838
9SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.54141489
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.51121337
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.51026693
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.49014801
13VDR_22108803_ChIP-Seq_LS180_Human2.47914163
14NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.47334583
15DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.43403356
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.39236641
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.36154030
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.32342532
19IRF8_22096565_ChIP-ChIP_GC-B_Human2.29329642
20PU.1_20513432_ChIP-Seq_Bcells_Mouse2.23477260
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.22991661
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.22108636
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.21557114
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.15612041
25VDR_23849224_ChIP-Seq_CD4+_Human2.12481011
26ERG_21242973_ChIP-ChIP_JURKAT_Human2.09590071
27GBX2_23144817_ChIP-Seq_PC3_Human2.08096577
28ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.05048888
29ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00860544
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.00441492
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.98825022
32VDR_21846776_ChIP-Seq_THP-1_Human1.96655014
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94679448
34LXR_22292898_ChIP-Seq_THP-1_Human1.91682735
35IRF1_19129219_ChIP-ChIP_H3396_Human1.87629092
36TET1_21451524_ChIP-Seq_MESCs_Mouse1.85594006
37SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.85262838
38SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.85144632
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.82590721
40POU5F1_16518401_ChIP-PET_MESCs_Mouse1.82197463
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.79039487
42RUNX_20019798_ChIP-Seq_JUKART_Human1.77654376
43TP53_22573176_ChIP-Seq_HFKS_Human1.76634079
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76463626
45GABP_19822575_ChIP-Seq_HepG2_Human1.75487106
46NANOG_21062744_ChIP-ChIP_HESCs_Human1.75290059
47ETS1_20019798_ChIP-Seq_JURKAT_Human1.72822169
48ZNF263_19887448_ChIP-Seq_K562_Human1.72455100
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72200956
50KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.70043763
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68606956
52NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.68400837
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.66948434
54DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.66466462
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.65381004
56RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.63807885
57SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63735158
58RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.61030451
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60922037
60SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.60604553
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.60283272
62GATA3_26560356_Chip-Seq_TH2_Human1.59271021
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.58874892
64HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.58676638
65NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.56751993
66ER_23166858_ChIP-Seq_MCF-7_Human1.56517552
67BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.56423020
68E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56112496
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.55564201
70CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.54760268
71EST1_17652178_ChIP-ChIP_JURKAT_Human1.52935230
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52473998
73ETS1_21867929_ChIP-Seq_TH2_Mouse1.50373211
74MYC_19030024_ChIP-ChIP_MESCs_Mouse1.48520077
75P300_19829295_ChIP-Seq_ESCs_Human1.46874238
76PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.46070023
77SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45859312
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45206167
79NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45142722
80MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44864399
81RXRA_24833708_ChIP-Seq_LIVER_Mouse1.44418209
82DCP1A_22483619_ChIP-Seq_HELA_Human1.43298905
83MYC_18940864_ChIP-ChIP_HL60_Human1.42730642
84STAT1_20625510_ChIP-Seq_HELA_Human1.40508734
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.39271895
86MYCN_18555785_ChIP-Seq_MESCs_Mouse1.38748013
87TCF3_18692474_ChIP-Seq_MESCs_Mouse1.38401550
88CBP_20019798_ChIP-Seq_JUKART_Human1.37852637
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37852637
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37500295
91FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.36895673
92KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.36624414
93KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.36624414
94KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.36624414
95REST_18959480_ChIP-ChIP_MESCs_Mouse1.35939699
96SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.35421611
97BCOR_27268052_Chip-Seq_Bcells_Human1.35266641
98CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35054033
99CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.34446784
100RARB_24833708_ChIP-Seq_LIVER_Mouse1.33688994
101NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.32972854
102EWS_26573619_Chip-Seq_HEK293_Human1.32399973
103SPI1_26923725_Chip-Seq_HPCs_Mouse1.32290989
104POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.32189655
105YY1_22570637_ChIP-Seq_MALME-3M_Human1.31828359
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31774945
107SRF_21415370_ChIP-Seq_HL-1_Mouse1.31256513
108TET1_21490601_ChIP-Seq_MESCs_Mouse1.30138322
109TCF4_23295773_ChIP-Seq_U87_Human1.29611617
110LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28714752
111IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.28594883
112NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.28518105
113CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.28492623
114BCAT_22108803_ChIP-Seq_LS180_Human1.28413904
115STAT3_23295773_ChIP-Seq_U87_Human1.28388922
116EZH2_27294783_Chip-Seq_NPCs_Mouse1.27655488
117P68_20966046_ChIP-Seq_HELA_Human1.27488362
118FOXP3_21729870_ChIP-Seq_TREG_Human1.27153396
119CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26638455
120FOXA1_25329375_ChIP-Seq_VCAP_Human1.26063556
121FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26063556
122PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25180824
123SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.24539967
124PHF8_20622854_ChIP-Seq_HELA_Human1.24334061
125ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24323659
126GATA3_21878914_ChIP-Seq_MCF-7_Human1.24112765
127AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23658820
128GABP_17652178_ChIP-ChIP_JURKAT_Human1.22088947
129CRX_20693478_ChIP-Seq_RETINA_Mouse1.21026851
130BCL6_27268052_Chip-Seq_Bcells_Human1.20749965
131REST_21632747_ChIP-Seq_MESCs_Mouse1.20664914
132MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20255590
133AR_20517297_ChIP-Seq_VCAP_Human1.19790280
134TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.19698028
135SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19426727
136STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19364005
137MYC_22102868_ChIP-Seq_BL_Human1.18826821
138CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18754652
139CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.18670649
140MYB_26560356_Chip-Seq_TH2_Human1.18400185
141SOX2_19829295_ChIP-Seq_ESCs_Human1.17456789
142NANOG_19829295_ChIP-Seq_ESCs_Human1.17456789
143SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.16443396
144SA1_27219007_Chip-Seq_ERYTHROID_Human1.16185002
145SMAD4_21799915_ChIP-Seq_A2780_Human1.15936152
146RARA_24833708_ChIP-Seq_LIVER_Mouse1.15929596
147HOXB7_26014856_ChIP-Seq_BT474_Human1.15781093
148CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14532097
149CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14424068
150GATA3_27048872_Chip-Seq_THYMUS_Human1.14313473
151ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14003630
152CTCF_21964334_ChIP-Seq_BJAB-B_Human1.13296810
153KDM5A_27292631_Chip-Seq_BREAST_Human1.12118119
154FOXP1_21924763_ChIP-Seq_HESCs_Human1.12048102
155RACK7_27058665_Chip-Seq_MCF-7_Human1.11792236
156CTCF_27219007_Chip-Seq_Bcells_Human1.11607317
157SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11257909
158EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10879871
159FLI1_21867929_ChIP-Seq_TH2_Mouse1.08875407
160FUS_26573619_Chip-Seq_HEK293_Human1.08743215
161E2F1_20622854_ChIP-Seq_HELA_Human1.08360605
162GATA1_22025678_ChIP-Seq_K562_Human1.08207361
163SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.08170263
164GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07835391
165SMC4_20622854_ChIP-Seq_HELA_Human1.07730754
166KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07680182
167PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07348040
168ELK1_19687146_ChIP-ChIP_HELA_Human1.06570741
169FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05975213
170CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04336843
171FLI1_21867929_ChIP-Seq_CD8_Mouse1.04114893
172PRDM14_20953172_ChIP-Seq_ESCs_Human1.04054848
173NCOR_22424771_ChIP-Seq_293T_Human1.03914279
174FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.02869576
175ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02783355
176AR_25329375_ChIP-Seq_VCAP_Human1.02759802
177CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.02203240
178SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01731781
179MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01326348
180TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00684468
181POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00684468
182SMRT_27268052_Chip-Seq_Bcells_Human1.00033838
183TCF4_22108803_ChIP-Seq_LS180_Human0.99178708
184PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98199092
185KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97062063
186TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96993212
187SMAD4_21741376_ChIP-Seq_EPCs_Human0.96794434
188ERA_21632823_ChIP-Seq_H3396_Human0.96069119
189OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96023868
190IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.95594529
191FOXH1_21741376_ChIP-Seq_EPCs_Human0.95373009
192OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94657009

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.62698476
2MP0004233_abnormal_muscle_weight3.81364876
3MP0005171_absent_coat_pigmentation3.64218202
4MP0000569_abnormal_digit_pigmentation3.54598879
5MP0002653_abnormal_ependyma_morphology3.11215064
6MP0002102_abnormal_ear_morphology2.93520062
7MP0010030_abnormal_orbit_morphology2.79867351
8MP0004147_increased_porphyrin_level2.74081379
9MP0006072_abnormal_retinal_apoptosis2.71314549
10MP0003718_maternal_effect2.64206557
11MP0005671_abnormal_response_to2.63544408
12MP0004859_abnormal_synaptic_plasticity2.44084376
13MP0009278_abnormal_bone_marrow2.26469821
14MP0008995_early_reproductive_senescence2.23850856
15MP0008877_abnormal_DNA_methylation2.18201342
16MP0002638_abnormal_pupillary_reflex2.15333234
17MP0002009_preneoplasia2.13012827
18MP0008872_abnormal_physiological_respon2.10043872
19MP0003656_abnormal_erythrocyte_physiolo2.05928720
20MP0001501_abnormal_sleep_pattern2.05778603
21MP0010094_abnormal_chromosome_stability2.02787864
22MP0003693_abnormal_embryo_hatching1.96238219
23MP0000372_irregular_coat_pigmentation1.95384249
24MP0003195_calcinosis1.95127218
25MP0002876_abnormal_thyroid_physiology1.86130872
26MP0003880_abnormal_central_pattern1.81280982
27MP0005645_abnormal_hypothalamus_physiol1.81089309
28MP0001502_abnormal_circadian_rhythm1.79356214
29MP0000015_abnormal_ear_pigmentation1.78573178
30MP0004043_abnormal_pH_regulation1.77466677
31MP0000579_abnormal_nail_morphology1.71807646
32MP0003786_premature_aging1.71730250
33MP0002163_abnormal_gland_morphology1.66707203
34MP0001968_abnormal_touch/_nociception1.65191408
35MP0009745_abnormal_behavioral_response1.62744399
36MP0003763_abnormal_thymus_physiology1.60606545
37MP0005174_abnormal_tail_pigmentation1.60199555
38MP0004142_abnormal_muscle_tone1.59533229
39MP0003137_abnormal_impulse_conducting1.59338299
40MP0002269_muscular_atrophy1.56923564
41MP0004957_abnormal_blastocyst_morpholog1.54651877
42MP0003890_abnormal_embryonic-extraembry1.53764317
43MP0000639_abnormal_adrenal_gland1.49800810
44MP0002063_abnormal_learning/memory/cond1.49689638
45MP0009046_muscle_twitch1.49188745
46MP0001545_abnormal_hematopoietic_system1.46357744
47MP0005397_hematopoietic_system_phenotyp1.46357744
48MP0001986_abnormal_taste_sensitivity1.46174065
49MP0001905_abnormal_dopamine_level1.46135506
50MP0001486_abnormal_startle_reflex1.45033921
51MP0002735_abnormal_chemical_nociception1.44273853
52MP0005167_abnormal_blood-brain_barrier1.43522373
53MP0002733_abnormal_thermal_nociception1.43139552
54MP0001970_abnormal_pain_threshold1.42339978
55MP0005075_abnormal_melanosome_morpholog1.41241334
56MP0003646_muscle_fatigue1.38425841
57MP0002249_abnormal_larynx_morphology1.38039783
58MP0005646_abnormal_pituitary_gland1.36773495
59MP0004742_abnormal_vestibular_system1.35904915
60MP0003635_abnormal_synaptic_transmissio1.34317234
61MP0001800_abnormal_humoral_immune1.33886945
62MP0000427_abnormal_hair_cycle1.33708547
63MP0002572_abnormal_emotion/affect_behav1.33416461
64MP0008932_abnormal_embryonic_tissue1.33027096
65MP0003011_delayed_dark_adaptation1.31863636
66MP0003111_abnormal_nucleus_morphology1.30489169
67MP0003172_abnormal_lysosome_physiology1.29860843
68MP0008875_abnormal_xenobiotic_pharmacok1.29847413
69MP0001919_abnormal_reproductive_system1.29383813
70MP0003119_abnormal_digestive_system1.29311288
71MP0009785_altered_susceptibility_to1.27782367
72MP0005000_abnormal_immune_tolerance1.26625963
73MP0003724_increased_susceptibility_to1.25568812
74MP0004133_heterotaxia1.23721063
75MP0000462_abnormal_digestive_system1.22812690
76MP0010386_abnormal_urinary_bladder1.22486245
77MP0008058_abnormal_DNA_repair1.21066754
78MP0001529_abnormal_vocalization1.20277902
79MP0002095_abnormal_skin_pigmentation1.19994635
80MP0004885_abnormal_endolymph1.18719056
81MP0002723_abnormal_immune_serum1.18558571
82MP0005084_abnormal_gallbladder_morpholo1.17975838
83MP0002736_abnormal_nociception_after1.17707956
84MP0002064_seizures1.13754961
85MP0003453_abnormal_keratinocyte_physiol1.12870144
86MP0003699_abnormal_female_reproductive1.12379785
87MP0005551_abnormal_eye_electrophysiolog1.12008530
88MP0005058_abnormal_lysosome_morphology1.11789014
89MP0000955_abnormal_spinal_cord1.10991002
90MP0006036_abnormal_mitochondrial_physio1.10372904
91MP0005647_abnormal_sex_gland1.09087097
92MP0005389_reproductive_system_phenotype1.07430048
93MP0001697_abnormal_embryo_size1.06740008
94MP0002420_abnormal_adaptive_immunity1.05187456
95MP0005266_abnormal_metabolism1.04871902
96MP0002928_abnormal_bile_duct1.03715333
97MP0001819_abnormal_immune_cell1.03493857
98MP0004145_abnormal_muscle_electrophysio1.03304443
99MP0002332_abnormal_exercise_endurance1.03293948
100MP0002272_abnormal_nervous_system1.02682185
101MP0000490_abnormal_crypts_of1.01503852
102MP0002452_abnormal_antigen_presenting1.00713109
103MP0004270_analgesia1.00450007
104MP0003077_abnormal_cell_cycle0.99512555
105MP0000470_abnormal_stomach_morphology0.99279739
106MP0002557_abnormal_social/conspecific_i0.99205211
107MP0005253_abnormal_eye_physiology0.98797707
108MP0006292_abnormal_olfactory_placode0.98125004
109MP0002277_abnormal_respiratory_mucosa0.97243498
110MP0001929_abnormal_gametogenesis0.97240134
111MP0004811_abnormal_neuron_physiology0.95087916
112MP0000751_myopathy0.95083521
113MP0002085_abnormal_embryonic_tissue0.93930994
114MP0005395_other_phenotype0.93673127
115MP0009764_decreased_sensitivity_to0.93468394
116MP0005083_abnormal_biliary_tract0.92841200
117MP0003329_amyloid_beta_deposits0.92650734
118MP0002084_abnormal_developmental_patter0.92561120
119MP0002148_abnormal_hypersensitivity_rea0.92183890
120MP0001984_abnormal_olfaction0.91425778
121MP0002229_neurodegeneration0.91042710
122MP0000371_diluted_coat_color0.90504902
123MP0000653_abnormal_sex_gland0.90427360
124MP0001145_abnormal_male_reproductive0.90282978
125MP0001835_abnormal_antigen_presentation0.90101361
126MP0002882_abnormal_neuron_morphology0.88742588
127MP0004924_abnormal_behavior0.88351191
128MP0005386_behavior/neurological_phenoty0.88351191
129MP0002066_abnormal_motor_capabilities/c0.87693734
130MP0005379_endocrine/exocrine_gland_phen0.87347835
131MP0001324_abnormal_eye_pigmentation0.87034157
132MP0004264_abnormal_extraembryonic_tissu0.84489636
133MP0000689_abnormal_spleen_morphology0.83818122
134MP0005310_abnormal_salivary_gland0.82785470
135MP0002161_abnormal_fertility/fecundity0.82591318
136MP0003183_abnormal_peptide_metabolism0.82552230
137MP0002254_reproductive_system_inflammat0.80975056
138MP0008569_lethality_at_weaning0.80628050
139MP0005365_abnormal_bile_salt0.80336581
140MP0001485_abnormal_pinna_reflex0.79972920
141MP0002734_abnormal_mechanical_nocicepti0.79408738
142MP0000631_abnormal_neuroendocrine_gland0.78524356
143MP0002184_abnormal_innervation0.78421232
144MP0001119_abnormal_female_reproductive0.78409224
145MP0000465_gastrointestinal_hemorrhage0.77791156
146MP0000685_abnormal_immune_system0.77754956
147MP0002210_abnormal_sex_determination0.77692316
148MP0002282_abnormal_trachea_morphology0.77681522
149MP0005499_abnormal_olfactory_system0.76872435
150MP0005394_taste/olfaction_phenotype0.76872435
151MP0005195_abnormal_posterior_eye0.76256010
152MP0008789_abnormal_olfactory_epithelium0.75899998
153MP0003075_altered_response_to0.75629020
154MP0002796_impaired_skin_barrier0.75220874
155MP0005025_abnormal_response_to0.75027032
156MP0002067_abnormal_sensory_capabilities0.74291736
157MP0002752_abnormal_somatic_nervous0.74193452
158MP0002019_abnormal_tumor_incidence0.73973702
159MP0000716_abnormal_immune_system0.73753209
160MP0003436_decreased_susceptibility_to0.73496288
161MP0008961_abnormal_basal_metabolism0.73381651
162MP0006276_abnormal_autonomic_nervous0.72886402
163MP0001730_embryonic_growth_arrest0.72232426

Predicted human phenotypes

RankGene SetZ-score
1Annular pancreas (HP:0001734)4.92835604
2Male infertility (HP:0003251)4.81415277
3Facial hemangioma (HP:0000329)4.78506308
4Increased IgM level (HP:0003496)4.53163208
5Rib fusion (HP:0000902)4.33519670
6Concave nail (HP:0001598)4.30334095
7Molar tooth sign on MRI (HP:0002419)4.20119501
8Abnormality of midbrain morphology (HP:0002418)4.20119501
9Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.14032831
10Poikiloderma (HP:0001029)4.11396406
11Pustule (HP:0200039)4.10431696
12IgG deficiency (HP:0004315)4.01737590
13Pancreatic cysts (HP:0001737)3.95705566
14Broad alveolar ridges (HP:0000187)3.86392447
15Tongue fasciculations (HP:0001308)3.80708491
16Rectal fistula (HP:0100590)3.56643439
17Rectovaginal fistula (HP:0000143)3.56643439
18Albinism (HP:0001022)3.45065476
19Type II lissencephaly (HP:0007260)3.44952850
20Nephronophthisis (HP:0000090)3.39452423
21Abnormality of the renal cortex (HP:0011035)3.38914519
22Alopecia of scalp (HP:0002293)3.38618515
23Muscle fibrillation (HP:0010546)3.37169815
24Abnormality of male internal genitalia (HP:0000022)3.36380815
25Myokymia (HP:0002411)3.35338637
26Dysautonomia (HP:0002459)3.32246027
27Turricephaly (HP:0000262)3.28523460
28Abnormality of the pons (HP:0007361)3.18679593
29Vaginal fistula (HP:0004320)3.14235871
30Intestinal fistula (HP:0100819)3.12818948
31Anteriorly placed anus (HP:0001545)3.12272653
32Narrow nasal bridge (HP:0000446)3.00070195
33Abnormality of the aortic arch (HP:0012303)2.99395659
34Pancreatic fibrosis (HP:0100732)2.99386637
35Congenital stationary night blindness (HP:0007642)2.99335787
36Abnormality of the renal medulla (HP:0100957)2.97095199
37Hypoplasia of the pons (HP:0012110)2.94462300
38Stomatitis (HP:0010280)2.93730565
39Atonic seizures (HP:0010819)2.92813364
40Abnormality of the labia minora (HP:0012880)2.89205129
41True hermaphroditism (HP:0010459)2.86833929
42Hyperventilation (HP:0002883)2.86409639
43Type 2 muscle fiber atrophy (HP:0003554)2.84489601
44Hypochromic microcytic anemia (HP:0004840)2.82591094
45Renal cortical cysts (HP:0000803)2.81735195
46Chronic hepatic failure (HP:0100626)2.81190628
47Orthostatic hypotension (HP:0001278)2.78939472
48Short chin (HP:0000331)2.78729220
49Congenital hip dislocation (HP:0001374)2.76341501
50Absent speech (HP:0001344)2.76285392
51Muscle fiber atrophy (HP:0100295)2.74542894
52Capillary hemangiomas (HP:0005306)2.72402963
53Cerebral hypomyelination (HP:0006808)2.71124391
54Abnormality of polysaccharide metabolism (HP:0011012)2.67519971
55Abnormality of glycosaminoglycan metabolism (HP:0004371)2.67519971
56Abnormality of mucopolysaccharide metabolism (HP:0011020)2.67519971
57Microretrognathia (HP:0000308)2.66583021
58Dysostosis multiplex (HP:0000943)2.66137501
59Large for gestational age (HP:0001520)2.64881500
60Urinary glycosaminoglycan excretion (HP:0003541)2.63423352
61Mucopolysacchariduria (HP:0008155)2.63423352
62Growth hormone excess (HP:0000845)2.62893488
63Progressive inability to walk (HP:0002505)2.58732681
64Lissencephaly (HP:0001339)2.58190110
65Diaphragmatic weakness (HP:0009113)2.56668499
66Short humerus (HP:0005792)2.51251772
67Severe combined immunodeficiency (HP:0004430)2.50229612
68Patellar aplasia (HP:0006443)2.49935792
69Ulnar bowing (HP:0003031)2.49025685
70Febrile seizures (HP:0002373)2.48436279
71Aplasia/hypoplasia of the humerus (HP:0006507)2.48330131
72Alacrima (HP:0000522)2.48069862
73Genetic anticipation (HP:0003743)2.46726910
74Exertional dyspnea (HP:0002875)2.44422359
75Hypokinesia (HP:0002375)2.44115789
76Broad-based gait (HP:0002136)2.44014342
77Absent radius (HP:0003974)2.42588360
78Intestinal atresia (HP:0011100)2.42478052
79Fetal akinesia sequence (HP:0001989)2.41882911
80Inability to walk (HP:0002540)2.36210587
81Medial flaring of the eyebrow (HP:0010747)2.35041869
82Thyroiditis (HP:0100646)2.32573625
83Aplasia/Hypoplasia of the tibia (HP:0005772)2.32480157
84Selective tooth agenesis (HP:0001592)2.31583638
85Amniotic constriction ring (HP:0009775)2.31204814
86Abnormality of placental membranes (HP:0011409)2.31204814
87Aplasia/Hypoplasia of the patella (HP:0006498)2.31095286
88Absent forearm bone (HP:0003953)2.30601754
89Aplasia involving forearm bones (HP:0009822)2.30601754
90Gaze-evoked nystagmus (HP:0000640)2.29266148
91Cerebellar dysplasia (HP:0007033)2.29039047
92Stomach cancer (HP:0012126)2.26290705
93Absence seizures (HP:0002121)2.25570615
94Epileptic encephalopathy (HP:0200134)2.24323335
95Squamous cell carcinoma (HP:0002860)2.23657140
96Birth length less than 3rd percentile (HP:0003561)2.23292483
97Short tibia (HP:0005736)2.22392795
98Abnormality of eosinophils (HP:0001879)2.21590299
99Coronal craniosynostosis (HP:0004440)2.20865218
100Lower limb hyperreflexia (HP:0002395)2.20504594
101Polydipsia (HP:0001959)2.19597818
102Abnormal drinking behavior (HP:0030082)2.19597818
103Hypercortisolism (HP:0001578)2.18039521
104Polycythemia (HP:0001901)2.17816879
105Absent thumb (HP:0009777)2.15139238
106Breast hypoplasia (HP:0003187)2.14563738
107Progressive cerebellar ataxia (HP:0002073)2.14390244
108Hypotrichosis (HP:0001006)2.14002756
109Abnormality of T cells (HP:0002843)2.13622162
110Joint stiffness (HP:0001387)2.13232516
111Attenuation of retinal blood vessels (HP:0007843)2.13165477
112Decreased electroretinogram (ERG) amplitude (HP:0000654)2.12526564
113T lymphocytopenia (HP:0005403)2.11710836
114Hypotelorism (HP:0000601)2.11701407
115Retinal dysplasia (HP:0007973)2.11363486
116Aplasia of the musculature (HP:0100854)2.10864039
117Redundant skin (HP:0001582)2.10182372
118Abnormality of T cell number (HP:0011839)2.08075523
119Asymmetric septal hypertrophy (HP:0001670)2.08053215
120Abnormal biliary tract physiology (HP:0012439)2.07346270
121Bile duct proliferation (HP:0001408)2.07346270
122Amelogenesis imperfecta (HP:0000705)2.06618050
123Tubular atrophy (HP:0000092)2.06575177
124Median cleft lip (HP:0000161)2.06016668
125Short 5th finger (HP:0009237)2.04862298
126Optic neuritis (HP:0100653)2.04167457
127Retrobulbar optic neuritis (HP:0100654)2.04167457
128Abnormality of alanine metabolism (HP:0010916)2.03385414
129Hyperalaninemia (HP:0003348)2.03385414
130Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.03385414
131Congenital primary aphakia (HP:0007707)2.03283588
132Clumsiness (HP:0002312)2.03067477
133Protruding tongue (HP:0010808)2.02659807
134Premature graying of hair (HP:0002216)2.02405180
1353-Methylglutaconic aciduria (HP:0003535)2.01890752
136Infertility (HP:0000789)2.01763999
137Decreased lacrimation (HP:0000633)2.01570307
138Congenital sensorineural hearing impairment (HP:0008527)2.01101893
139Poor suck (HP:0002033)2.01097351
140Abnormality of T cell physiology (HP:0011840)2.00728686
141Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.00327755
142Vertebral hypoplasia (HP:0008417)2.00327755
143Delusions (HP:0000746)1.96287936
144Diminished movement (HP:0002374)1.96138841
145Methylmalonic acidemia (HP:0002912)1.95553506
146Gait imbalance (HP:0002141)1.95466703
147Anhidrosis (HP:0000970)1.95342061
148Agitation (HP:0000713)1.94294980
149Premature skin wrinkling (HP:0100678)1.93319560
150Methylmalonic aciduria (HP:0012120)1.93308615
151Generalized hypopigmentation (HP:0007513)1.92660860
152Hypochromic anemia (HP:0001931)1.90755649
153Hamartoma (HP:0010566)1.90244881
154Abnormal hemoglobin (HP:0011902)1.90206584
155Basal cell carcinoma (HP:0002671)1.90193119
156Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.89797013
157Anterior segment dysgenesis (HP:0007700)1.89670195
158Exercise-induced myalgia (HP:0003738)1.89209488
159Hypothermia (HP:0002045)1.88425236
160Anencephaly (HP:0002323)1.88285356
161Emotional lability (HP:0000712)1.87856112
162Abnormality of the lower motor neuron (HP:0002366)1.87822651
163Aplasia/Hypoplasia involving the musculature (HP:0001460)1.85446777
164Pachygyria (HP:0001302)1.84631478
165Increased CSF lactate (HP:0002490)1.84383709
166Abolished electroretinogram (ERG) (HP:0000550)1.81499498
167Hepatocellular necrosis (HP:0001404)1.81392496
168Aplasia/hypoplasia of the uterus (HP:0008684)1.80510372
169Widely spaced teeth (HP:0000687)1.79600225
170Pendular nystagmus (HP:0012043)1.79383916
171Aplasia/Hypoplasia of the spleen (HP:0010451)1.79134719
172Elevated erythrocyte sedimentation rate (HP:0003565)1.79052248
173Nephrogenic diabetes insipidus (HP:0009806)1.78989386
174Asplenia (HP:0001746)1.77639545
175Hypoplasia of the fovea (HP:0007750)1.77052060
176Aplasia/Hypoplasia of the fovea (HP:0008060)1.77052060
177Combined immunodeficiency (HP:0005387)1.76281091
178Cystic liver disease (HP:0006706)1.75108315
179IgA deficiency (HP:0002720)1.73976278
180Thyroid-stimulating hormone excess (HP:0002925)1.72848867
181Abnormality of the fovea (HP:0000493)1.71715609
182Abnormal delayed hypersensitivity skin test (HP:0002963)1.71701209
183Mitochondrial inheritance (HP:0001427)1.70416827
184Increased serum lactate (HP:0002151)1.68702830
185Myositis (HP:0100614)1.67729463
186Congenital hepatic fibrosis (HP:0002612)1.67296144
187Fair hair (HP:0002286)1.66699336
188Polyuria (HP:0000103)1.66137595
189Conical tooth (HP:0000698)1.64517196
190Progressive microcephaly (HP:0000253)1.64237719
191Sclerocornea (HP:0000647)1.62364797
192Mutism (HP:0002300)1.60758321

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K65.47556458
2ICK4.57335225
3PINK13.91427350
4MAPK153.86986717
5DDR23.85260021
6TXK3.62326080
7TAOK33.42814329
8MAP4K23.36899785
9MAP3K113.23932419
10FRK3.16934995
11ACVR1B2.87836247
12TYRO32.78745365
13DAPK12.72049029
14SIK22.69855212
15FGR2.64182673
16MATK2.60504066
17TLK12.59621657
18ADRBK22.53691825
19ZAK2.53051119
20WNK32.33089402
21LATS22.27008553
22PRKD22.23836606
23MAP3K92.21674706
24NUAK12.20614620
25CASK2.13226884
26BMPR1B2.07827863
27UHMK12.02008372
28PRPF4B2.00887262
29RAF11.91112658
30IKBKE1.78792940
31DAPK21.77907205
32GRK61.74829557
33KSR21.71102778
34TRIM281.70866253
35PAK61.66776881
36PHKG11.64717643
37PHKG21.64717643
38MAP3K141.64586099
39CAMKK21.63598221
40DYRK1B1.54407655
41WNK41.44476649
42PIM21.42897348
43IKBKB1.42245277
44BMX1.41643509
45YES11.39280767
46BCR1.34797612
47GRK11.33055934
48TAOK11.32742309
49NME11.26521772
50DYRK31.21362879
51CSK1.18104933
52DYRK21.13837000
53OXSR11.13612852
54FES1.11689246
55MAP2K61.11021677
56CSNK1A1L1.10760023
57CDK71.10237669
58TRPM71.10159288
59PDGFRA1.09479318
60MAP2K21.09422621
61MST41.08965426
62CHEK21.08056084
63ARAF1.06528833
64MAPKAPK31.05770063
65CAMKK11.02399268
66MAPK111.00603554
67INSRR0.97227791
68PDK20.97045910
69NEK10.94765705
70TAOK20.88712140
71VRK10.88141584
72TBK10.87454912
73PRKD30.86821834
74PRKAA10.86356784
75EPHA40.84612527
76MAP4K10.83444056
77CDC42BPA0.82280423
78STK38L0.81038689
79PLK10.80874645
80PAK30.79831760
81PRKCQ0.78339342
82STK390.77784578
83AKT30.77421570
84BRSK10.75952710
85STK380.75925410
86NTRK20.75292724
87TNIK0.75007398
88SYK0.72352881
89EPHA30.71639570
90CDK11A0.69543134
91CDK150.69445826
92PIM10.68440095
93CDK180.67765457
94LCK0.67553812
95BRAF0.67392510
96SRPK10.67363048
97EIF2AK30.66638781
98CAMK2G0.65501937
99MARK10.65162328
100CDK80.65011831
101MARK20.63412665
102CDK60.63398991
103CAMK2B0.62883359
104TNK20.62087485
105CAMK2A0.61962362
106CHUK0.61287926
107MAP3K40.60474673
108CDK190.60035776
109CDC70.59912105
110HIPK20.59247596
111AURKA0.59235279
112MUSK0.59234873
113CDK140.59017290
114KSR10.58506929
115PTK2B0.57977798
116BLK0.56669802
117ADRBK10.56469886
118PLK20.55429878
119RPS6KA50.54628832
120JAK10.54011083
121TESK20.52721927
122RPS6KC10.52613928
123RPS6KL10.52613928
124CSNK1G10.52286206
125ITK0.51713121
126ERBB40.50556697
127MAPK130.49692495
128MAP2K70.49618996
129CAMK40.49301401
130BUB10.48606915
131PRKCE0.47390336
132BRSK20.47255429
133MOS0.46922165
134NEK20.45914162
135TGFBR10.45856921
136NEK60.45569594
137EIF2AK20.43905046
138RPS6KA60.43308963
139PRKAA20.42316067
140PKN10.41850980
141CSNK1D0.40669804
142BMPR20.40572501
143BCKDK0.40313683
144PRKCG0.40082725
145CAMK2D0.39291246
146MINK10.38164919
147GSK3A0.38155756
148RPS6KA10.37716852
149PRKCI0.37473325
150BRD40.36699624
151OBSCN0.36647619
152ERBB30.36135626
153TEC0.36069723
154CDK50.35243211
155PIK3CA0.34420876
156MARK30.33931110
157JAK30.32750689
158CAMK10.32482462
159RPS6KB20.32326191
160NTRK30.31704736
161CSNK1G30.30774298
162CSF1R0.29595111
163PRKCZ0.29234472
164LIMK10.28628269
165MAP3K120.28437055
166LYN0.27985965
167MAP3K130.26488562
168CDK20.25889913
169MAPK40.24797853
170CSNK1G20.24215124
171CSNK2A10.24063111
172MAPK100.23305203
173DYRK1A0.23269583

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.67602294
2Mismatch repair_Homo sapiens_hsa034304.07959533
3Base excision repair_Homo sapiens_hsa034103.97225727
4Circadian rhythm_Homo sapiens_hsa047103.66511245
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.21862935
6DNA replication_Homo sapiens_hsa030303.21358646
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.66569768
8Phototransduction_Homo sapiens_hsa047442.52849230
9Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.48475746
10Nucleotide excision repair_Homo sapiens_hsa034202.19797515
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.16671298
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.12217718
13Sulfur relay system_Homo sapiens_hsa041222.09762641
14Arginine and proline metabolism_Homo sapiens_hsa003302.09135647
15Selenocompound metabolism_Homo sapiens_hsa004502.07821833
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.04814967
17Biosynthesis of amino acids_Homo sapiens_hsa012302.02001300
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.97725448
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.95720016
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.85342221
21Folate biosynthesis_Homo sapiens_hsa007901.81430987
22mTOR signaling pathway_Homo sapiens_hsa041501.80508419
23Synaptic vesicle cycle_Homo sapiens_hsa047211.75758327
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.70792742
25Butanoate metabolism_Homo sapiens_hsa006501.69701524
26Homologous recombination_Homo sapiens_hsa034401.62695371
27Oocyte meiosis_Homo sapiens_hsa041141.62627010
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.60722545
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.59809466
30Cell cycle_Homo sapiens_hsa041101.58961888
31Protein export_Homo sapiens_hsa030601.57491565
32RNA transport_Homo sapiens_hsa030131.53423871
33Propanoate metabolism_Homo sapiens_hsa006401.40496727
34Nitrogen metabolism_Homo sapiens_hsa009101.38399105
35Longevity regulating pathway - mammal_Homo sapiens_hsa042111.36324590
36Nicotine addiction_Homo sapiens_hsa050331.32349328
37mRNA surveillance pathway_Homo sapiens_hsa030151.30807774
38Olfactory transduction_Homo sapiens_hsa047401.30654778
39T cell receptor signaling pathway_Homo sapiens_hsa046601.29894522
40VEGF signaling pathway_Homo sapiens_hsa043701.26907273
41Ovarian steroidogenesis_Homo sapiens_hsa049131.26432332
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.25652345
43ABC transporters_Homo sapiens_hsa020101.23987880
44Ether lipid metabolism_Homo sapiens_hsa005651.23488311
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22484971
46Notch signaling pathway_Homo sapiens_hsa043301.20471015
47Taste transduction_Homo sapiens_hsa047421.18498436
48Fanconi anemia pathway_Homo sapiens_hsa034601.17365769
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16731320
50Hippo signaling pathway_Homo sapiens_hsa043901.13639089
51RNA polymerase_Homo sapiens_hsa030201.12697883
52p53 signaling pathway_Homo sapiens_hsa041151.11977475
53GABAergic synapse_Homo sapiens_hsa047271.10894007
54Tryptophan metabolism_Homo sapiens_hsa003801.09141606
55Fructose and mannose metabolism_Homo sapiens_hsa000511.08825421
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07442080
57Spliceosome_Homo sapiens_hsa030401.06223954
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.03561700
59Fatty acid metabolism_Homo sapiens_hsa012121.01904145
60NOD-like receptor signaling pathway_Homo sapiens_hsa046211.01804781
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00562913
62Gap junction_Homo sapiens_hsa045401.00419286
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.95736653
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95669298
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.93564269
66Choline metabolism in cancer_Homo sapiens_hsa052310.92975894
67Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.92701926
68Basal transcription factors_Homo sapiens_hsa030220.90298198
69Hedgehog signaling pathway_Homo sapiens_hsa043400.89689411
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89415112
71Shigellosis_Homo sapiens_hsa051310.88565082
72Peroxisome_Homo sapiens_hsa041460.88317161
73Bladder cancer_Homo sapiens_hsa052190.86819006
74Graft-versus-host disease_Homo sapiens_hsa053320.85520303
75Measles_Homo sapiens_hsa051620.82749556
76RNA degradation_Homo sapiens_hsa030180.82525159
77Vitamin B6 metabolism_Homo sapiens_hsa007500.82034520
78Arginine biosynthesis_Homo sapiens_hsa002200.80898518
79Autoimmune thyroid disease_Homo sapiens_hsa053200.78832519
80Allograft rejection_Homo sapiens_hsa053300.78377670
81ErbB signaling pathway_Homo sapiens_hsa040120.76852039
82Caffeine metabolism_Homo sapiens_hsa002320.76611474
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.76368022
84Hematopoietic cell lineage_Homo sapiens_hsa046400.75547202
85Colorectal cancer_Homo sapiens_hsa052100.74536184
86Wnt signaling pathway_Homo sapiens_hsa043100.73899108
87Circadian entrainment_Homo sapiens_hsa047130.71955913
88GnRH signaling pathway_Homo sapiens_hsa049120.71430499
89Regulation of autophagy_Homo sapiens_hsa041400.69454079
90Alzheimers disease_Homo sapiens_hsa050100.68956458
91Non-homologous end-joining_Homo sapiens_hsa034500.68703287
92Proteasome_Homo sapiens_hsa030500.67762265
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66437780
94TNF signaling pathway_Homo sapiens_hsa046680.66143922
95Asthma_Homo sapiens_hsa053100.64740811
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64356053
97Purine metabolism_Homo sapiens_hsa002300.63572173
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.62456419
99Morphine addiction_Homo sapiens_hsa050320.61676084
100Salivary secretion_Homo sapiens_hsa049700.59251706
101Type I diabetes mellitus_Homo sapiens_hsa049400.59062483
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57918124
103Rheumatoid arthritis_Homo sapiens_hsa053230.57815056
104TGF-beta signaling pathway_Homo sapiens_hsa043500.57318544
105N-Glycan biosynthesis_Homo sapiens_hsa005100.57016642
106Herpes simplex infection_Homo sapiens_hsa051680.55221556
107Linoleic acid metabolism_Homo sapiens_hsa005910.54454306
108Glutamatergic synapse_Homo sapiens_hsa047240.54309427
109Arachidonic acid metabolism_Homo sapiens_hsa005900.52777844
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51055512
111Cardiac muscle contraction_Homo sapiens_hsa042600.51037005
112Glycerolipid metabolism_Homo sapiens_hsa005610.51019894
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50394666
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49399417
115Dopaminergic synapse_Homo sapiens_hsa047280.49310637
116Galactose metabolism_Homo sapiens_hsa000520.48613534
117Huntingtons disease_Homo sapiens_hsa050160.48406928
118Pyruvate metabolism_Homo sapiens_hsa006200.48335081
119Sulfur metabolism_Homo sapiens_hsa009200.47983437
120Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47659323
121Amphetamine addiction_Homo sapiens_hsa050310.47301642
122Calcium signaling pathway_Homo sapiens_hsa040200.47255317
123Primary immunodeficiency_Homo sapiens_hsa053400.46080211
124Insulin signaling pathway_Homo sapiens_hsa049100.45245904
125Glycosaminoglycan degradation_Homo sapiens_hsa005310.45061000
126Maturity onset diabetes of the young_Homo sapiens_hsa049500.44943097
127Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44486889
128Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.44157756
129AMPK signaling pathway_Homo sapiens_hsa041520.43658925
130Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43295940
131Pyrimidine metabolism_Homo sapiens_hsa002400.43092990
132Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42210181
133Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42019123
134Endocytosis_Homo sapiens_hsa041440.41125311
135Cholinergic synapse_Homo sapiens_hsa047250.39925760
136Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38557930
137Long-term depression_Homo sapiens_hsa047300.37579444
138Oxytocin signaling pathway_Homo sapiens_hsa049210.37327770
139Primary bile acid biosynthesis_Homo sapiens_hsa001200.35842888
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35512367
141cAMP signaling pathway_Homo sapiens_hsa040240.34196531
142Metabolic pathways_Homo sapiens_hsa011000.33362471
143Adherens junction_Homo sapiens_hsa045200.32990249
144Sphingolipid signaling pathway_Homo sapiens_hsa040710.32732053
145MAPK signaling pathway_Homo sapiens_hsa040100.32655465
146Collecting duct acid secretion_Homo sapiens_hsa049660.32264003
147Parkinsons disease_Homo sapiens_hsa050120.32196085
148Oxidative phosphorylation_Homo sapiens_hsa001900.31374767
149Insulin secretion_Homo sapiens_hsa049110.30089808
150Thyroid cancer_Homo sapiens_hsa052160.26735452
151Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26735121
152Cyanoamino acid metabolism_Homo sapiens_hsa004600.25924430
153Dorso-ventral axis formation_Homo sapiens_hsa043200.25439851
154Serotonergic synapse_Homo sapiens_hsa047260.23539318
155Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22981383
156Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22798931
157Steroid biosynthesis_Homo sapiens_hsa001000.22260270

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