

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 7.57951713 |
| 2 | ATP synthesis coupled proton transport (GO:0015986) | 7.24923547 |
| 3 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 7.24923547 |
| 4 | ribosomal small subunit biogenesis (GO:0042274) | 5.94834765 |
| 5 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 5.81701059 |
| 6 | ribosomal small subunit assembly (GO:0000028) | 5.73425264 |
| 7 | viral transcription (GO:0019083) | 5.67684833 |
| 8 | chaperone-mediated protein transport (GO:0072321) | 5.51529337 |
| 9 | translational termination (GO:0006415) | 5.36265478 |
| 10 | respiratory electron transport chain (GO:0022904) | 5.36118021 |
| 11 | protein neddylation (GO:0045116) | 5.31299133 |
| 12 | electron transport chain (GO:0022900) | 5.25652093 |
| 13 | cotranslational protein targeting to membrane (GO:0006613) | 5.13467588 |
| 14 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 5.12166286 |
| 15 | protein targeting to ER (GO:0045047) | 5.03832958 |
| 16 | sperm motility (GO:0030317) | 4.94084808 |
| 17 | behavioral response to nicotine (GO:0035095) | 4.88423098 |
| 18 | protein localization to endoplasmic reticulum (GO:0070972) | 4.84364765 |
| 19 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.75700056 |
| 20 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.73405991 |
| 21 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.73405991 |
| 22 | NADH dehydrogenase complex assembly (GO:0010257) | 4.73405991 |
| 23 | maturation of SSU-rRNA (GO:0030490) | 4.71562331 |
| 24 | protein complex biogenesis (GO:0070271) | 4.64522427 |
| 25 | translational elongation (GO:0006414) | 4.62405211 |
| 26 | regulation of female gonad development (GO:2000194) | 4.60506165 |
| 27 | cellular ketone body metabolic process (GO:0046950) | 4.49113250 |
| 28 | negative regulation of translation, ncRNA-mediated (GO:0040033) | 4.43039475 |
| 29 | regulation of translation, ncRNA-mediated (GO:0045974) | 4.43039475 |
| 30 | negative regulation of translation involved in gene silencing by miRNA (GO:0035278) | 4.43039475 |
| 31 | cellular protein complex disassembly (GO:0043624) | 4.38988272 |
| 32 | viral life cycle (GO:0019058) | 4.31939662 |
| 33 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.23435970 |
| 34 | cilium or flagellum-dependent cell motility (GO:0001539) | 4.22967386 |
| 35 | regulation of sarcomere organization (GO:0060297) | 4.22028555 |
| 36 | protein polyglutamylation (GO:0018095) | 4.21764478 |
| 37 | proteasome assembly (GO:0043248) | 4.19307838 |
| 38 | acrosome reaction (GO:0007340) | 4.16200294 |
| 39 | tryptophan catabolic process (GO:0006569) | 4.11281663 |
| 40 | indole-containing compound catabolic process (GO:0042436) | 4.11281663 |
| 41 | indolalkylamine catabolic process (GO:0046218) | 4.11281663 |
| 42 | GTP biosynthetic process (GO:0006183) | 4.06132144 |
| 43 | ketone body metabolic process (GO:1902224) | 4.02455468 |
| 44 | translation (GO:0006412) | 3.98676917 |
| 45 | NAD biosynthetic process (GO:0009435) | 3.95816373 |
| 46 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.95471165 |
| 47 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.91744304 |
| 48 | kynurenine metabolic process (GO:0070189) | 3.88730640 |
| 49 | oxidative phosphorylation (GO:0006119) | 3.88247618 |
| 50 | translational initiation (GO:0006413) | 3.86664472 |
| 51 | detection of light stimulus involved in sensory perception (GO:0050962) | 3.80392355 |
| 52 | detection of light stimulus involved in visual perception (GO:0050908) | 3.80392355 |
| 53 | response to misfolded protein (GO:0051788) | 3.79969653 |
| 54 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.78081694 |
| 55 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.76376856 |
| 56 | indolalkylamine metabolic process (GO:0006586) | 3.76281777 |
| 57 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.75457022 |
| 58 | dopamine transport (GO:0015872) | 3.75226274 |
| 59 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.72018186 |
| 60 | sequestering of actin monomers (GO:0042989) | 3.71825735 |
| 61 | protein complex disassembly (GO:0043241) | 3.71194022 |
| 62 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.71166532 |
| 63 | termination of RNA polymerase III transcription (GO:0006386) | 3.71166532 |
| 64 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.68261794 |
| 65 | ATP biosynthetic process (GO:0006754) | 3.67875345 |
| 66 | 7-methylguanosine mRNA capping (GO:0006370) | 3.65623731 |
| 67 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.64484924 |
| 68 | RNA capping (GO:0036260) | 3.60716959 |
| 69 | 7-methylguanosine RNA capping (GO:0009452) | 3.60716959 |
| 70 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.59855170 |
| 71 | positive regulation of protein homodimerization activity (GO:0090073) | 3.59645111 |
| 72 | macromolecular complex disassembly (GO:0032984) | 3.59224327 |
| 73 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.58731482 |
| 74 | multicellular organism reproduction (GO:0032504) | 3.57145986 |
| 75 | response to pheromone (GO:0019236) | 3.55891971 |
| 76 | membrane depolarization during action potential (GO:0086010) | 3.54281549 |
| 77 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.52886445 |
| 78 | cullin deneddylation (GO:0010388) | 3.51177282 |
| 79 | respiratory chain complex IV assembly (GO:0008535) | 3.50850347 |
| 80 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.50265876 |
| 81 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.50265876 |
| 82 | hydrogen ion transmembrane transport (GO:1902600) | 3.49343921 |
| 83 | negative regulation of ligase activity (GO:0051352) | 3.47098007 |
| 84 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.47098007 |
| 85 | protein K48-linked deubiquitination (GO:0071108) | 3.47047015 |
| 86 | inner mitochondrial membrane organization (GO:0007007) | 3.46515666 |
| 87 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.45650828 |
| 88 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.45650828 |
| 89 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.45650828 |
| 90 | tryptophan metabolic process (GO:0006568) | 3.45162334 |
| 91 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.43408262 |
| 92 | calcium ion-dependent exocytosis (GO:0017156) | 3.42511740 |
| 93 | ribosomal large subunit biogenesis (GO:0042273) | 3.40574852 |
| 94 | UTP biosynthetic process (GO:0006228) | 3.39000524 |
| 95 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.37434576 |
| 96 | protein targeting to membrane (GO:0006612) | 3.37210592 |
| 97 | L-fucose catabolic process (GO:0042355) | 3.32108574 |
| 98 | fucose catabolic process (GO:0019317) | 3.32108574 |
| 99 | L-fucose metabolic process (GO:0042354) | 3.32108574 |
| 100 | protein targeting to mitochondrion (GO:0006626) | 3.31757937 |
| 101 | establishment of integrated proviral latency (GO:0075713) | 3.31722880 |
| 102 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.30615874 |
| 103 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.30615874 |
| 104 | CTP metabolic process (GO:0046036) | 3.30506550 |
| 105 | CTP biosynthetic process (GO:0006241) | 3.30506550 |
| 106 | DNA deamination (GO:0045006) | 3.30248205 |
| 107 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.30229784 |
| 108 | protein deneddylation (GO:0000338) | 3.29904724 |
| 109 | regulation of cilium movement (GO:0003352) | 3.29802459 |
| 110 | establishment of protein localization to Golgi (GO:0072600) | 3.27846746 |
| 111 | axoneme assembly (GO:0035082) | 3.27690222 |
| 112 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.27359764 |
| 113 | fusion of sperm to egg plasma membrane (GO:0007342) | 3.22422458 |
| 114 | aerobic respiration (GO:0009060) | 3.22003182 |
| 115 | establishment of protein localization to mitochondrion (GO:0072655) | 3.20445016 |
| 116 | positive regulation of CREB transcription factor activity (GO:0032793) | 3.19759342 |
| 117 | monoubiquitinated protein deubiquitination (GO:0035520) | 3.19201822 |
| 118 | cytochrome complex assembly (GO:0017004) | 3.16076934 |
| 119 | proton transport (GO:0015992) | 3.15199286 |
| 120 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.12099726 |
| 121 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.11533774 |
| 122 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.10424162 |
| 123 | cellular biogenic amine catabolic process (GO:0042402) | 3.09328122 |
| 124 | amine catabolic process (GO:0009310) | 3.09328122 |
| 125 | hydrogen transport (GO:0006818) | 3.08402936 |
| 126 | gamma-aminobutyric acid transport (GO:0015812) | 3.06500320 |
| 127 | reflex (GO:0060004) | 3.06119509 |
| 128 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.05869354 |
| 129 | nucleoside triphosphate biosynthetic process (GO:0009142) | 3.05439382 |
| 130 | establishment of viral latency (GO:0019043) | 3.04768432 |
| 131 | regulation of cellular amine metabolic process (GO:0033238) | 3.04309981 |
| 132 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 3.04296187 |
| 133 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.01475420 |
| 134 | iron-sulfur cluster assembly (GO:0016226) | 3.01325780 |
| 135 | metallo-sulfur cluster assembly (GO:0031163) | 3.01325780 |
| 136 | spermatid development (GO:0007286) | 3.00895278 |
| 137 | cellular component biogenesis (GO:0044085) | 2.98850811 |
| 138 | peptidyl-threonine dephosphorylation (GO:0035970) | 2.98601192 |
| 139 | protein localization to mitochondrion (GO:0070585) | 2.97704781 |
| 140 | signal peptide processing (GO:0006465) | 2.96094975 |
| 141 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 2.95641972 |
| 142 | protein K63-linked deubiquitination (GO:0070536) | 2.95619539 |
| 143 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.94491236 |
| 144 | regulation of oxidative phosphorylation (GO:0002082) | 2.94226415 |
| 145 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 2.94225223 |
| 146 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 2.93064736 |
| 147 | nicotinamide nucleotide biosynthetic process (GO:0019359) | 2.92413990 |
| 148 | pyridine nucleotide biosynthetic process (GO:0019363) | 2.92413990 |
| 149 | striated muscle atrophy (GO:0014891) | 2.92200966 |
| 150 | cAMP catabolic process (GO:0006198) | 2.90942537 |
| 151 | primary amino compound metabolic process (GO:1901160) | 2.89658401 |
| 152 | multicellular organismal movement (GO:0050879) | 2.89527828 |
| 153 | musculoskeletal movement (GO:0050881) | 2.89527828 |
| 154 | indole-containing compound metabolic process (GO:0042430) | 2.88894195 |
| 155 | phosphatidylethanolamine biosynthetic process (GO:0006646) | 2.88145861 |
| 156 | epithelial cilium movement (GO:0003351) | 2.88098008 |
| 157 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.87634763 |
| 158 | motile cilium assembly (GO:0044458) | 2.85673571 |
| 159 | cilium movement (GO:0003341) | 2.83619841 |
| 160 | detection of mechanical stimulus involved in sensory perception of sound (GO:0050910) | 2.76709682 |
| 161 | skeletal muscle adaptation (GO:0043501) | 2.75375183 |
| 162 | spinal cord motor neuron differentiation (GO:0021522) | 2.73966106 |
| 163 | axonemal dynein complex assembly (GO:0070286) | 2.73722231 |
| 164 | regulation of skeletal muscle contraction (GO:0014819) | 2.72049358 |
| 165 | regulation of hippo signaling (GO:0035330) | 2.70976400 |
| 166 | calcium ion import (GO:0070509) | 2.69681961 |
| 167 | phosphatidylethanolamine metabolic process (GO:0046337) | 2.67838799 |
| 168 | regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211) | 2.66418648 |
| 169 | positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213) | 2.66418648 |
| 170 | neuronal action potential (GO:0019228) | 2.64101969 |
| 171 | regulation of Rab GTPase activity (GO:0032313) | 2.61993696 |
| 172 | positive regulation of Rab GTPase activity (GO:0032851) | 2.61993696 |
| 173 | negative regulation of systemic arterial blood pressure (GO:0003085) | 2.61025831 |
| 174 | response to gravity (GO:0009629) | 2.60497117 |
| 175 | alanine transport (GO:0032328) | 2.60350425 |
| 176 | cyclic nucleotide catabolic process (GO:0009214) | 2.59651625 |
| 177 | nonmotile primary cilium assembly (GO:0035058) | 2.58205085 |
| 178 | interkinetic nuclear migration (GO:0022027) | 2.57625593 |
| 179 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla | 2.56913615 |
| 180 | microtubule severing (GO:0051013) | 2.54732614 |
| 181 | cellular potassium ion transport (GO:0071804) | 2.54103789 |
| 182 | potassium ion transmembrane transport (GO:0071805) | 2.54103789 |
| 183 | organic cation transport (GO:0015695) | 2.53805157 |
| 184 | serotonin metabolic process (GO:0042428) | 2.53315136 |
| 185 | sulfation (GO:0051923) | 2.53295550 |
| 186 | negative regulation of cAMP-mediated signaling (GO:0043951) | 2.53151455 |
| 187 | microtubule polymerization or depolymerization (GO:0031109) | 2.52065803 |
| 188 | plasma membrane fusion (GO:0045026) | 2.51085297 |
| 189 | auditory receptor cell stereocilium organization (GO:0060088) | 2.50257414 |
| 190 | cilium organization (GO:0044782) | 2.50007761 |
| 191 | negative regulation of Rho protein signal transduction (GO:0035024) | 2.49571642 |
| 192 | misfolded or incompletely synthesized protein catabolic process (GO:0006515) | 2.48895138 |
| 193 | reproduction (GO:0000003) | 2.47997482 |
| 194 | regulation of action potential (GO:0098900) | 2.47281239 |
| 195 | microtubule depolymerization (GO:0007019) | 2.46393154 |
| 196 | protein targeting to Golgi (GO:0000042) | 2.46321102 |
| 197 | sperm capacitation (GO:0048240) | 2.46129806 |
| 198 | dendritic spine morphogenesis (GO:0060997) | 2.46035966 |
| 199 | cilium assembly (GO:0042384) | 2.45819287 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 6.12961534 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.75148779 |
| 3 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.40850469 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.34498009 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 4.01457313 |
| 6 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.76802705 |
| 7 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.50584805 |
| 8 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 3.49574170 |
| 9 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.45475618 |
| 10 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.45172841 |
| 11 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.21707874 |
| 12 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.16713509 |
| 13 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.94015513 |
| 14 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.83972644 |
| 15 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.83871786 |
| 16 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.75236244 |
| 17 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.74095664 |
| 18 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.60971349 |
| 19 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.60521773 |
| 20 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.58779364 |
| 21 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.51716391 |
| 22 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.51448606 |
| 23 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.42849905 |
| 24 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.34973992 |
| 25 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 2.30202889 |
| 26 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.29409657 |
| 27 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.26684129 |
| 28 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.25501845 |
| 29 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 2.22671606 |
| 30 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.18798674 |
| 31 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.18725731 |
| 32 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.13291573 |
| 33 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 2.01408473 |
| 34 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 2.00353762 |
| 35 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.99189847 |
| 36 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.96549546 |
| 37 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.94520431 |
| 38 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.92295233 |
| 39 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.91015646 |
| 40 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.90610704 |
| 41 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.89062627 |
| 42 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.84586770 |
| 43 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.82930779 |
| 44 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.82502565 |
| 45 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.81985525 |
| 46 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.81781274 |
| 47 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.81781274 |
| 48 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.80908508 |
| 49 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.80865476 |
| 50 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.77756087 |
| 51 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.75571337 |
| 52 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.73872549 |
| 53 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.62549947 |
| 54 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.61914236 |
| 55 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.56228042 |
| 56 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.54669101 |
| 57 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.54642243 |
| 58 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.53879251 |
| 59 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.52750932 |
| 60 | VDR_22108803_ChIP-Seq_LS180_Human | 1.52091411 |
| 61 | STAT3_23295773_ChIP-Seq_U87_Human | 1.48699633 |
| 62 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.45023410 |
| 63 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.44340459 |
| 64 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.42519632 |
| 65 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.42095873 |
| 66 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.40970074 |
| 67 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.37944784 |
| 68 | TCF4_23295773_ChIP-Seq_U87_Human | 1.37539041 |
| 69 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.36557763 |
| 70 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 1.36057527 |
| 71 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.35052689 |
| 72 | P300_19829295_ChIP-Seq_ESCs_Human | 1.34021716 |
| 73 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.33997721 |
| 74 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.32883205 |
| 75 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.32754169 |
| 76 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.32443653 |
| 77 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.32249944 |
| 78 | ERA_21632823_ChIP-Seq_H3396_Human | 1.31562676 |
| 79 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.30336478 |
| 80 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.29393376 |
| 81 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.29388653 |
| 82 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.29167732 |
| 83 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.29167732 |
| 84 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.26583920 |
| 85 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.26189652 |
| 86 | AR_25329375_ChIP-Seq_VCAP_Human | 1.25834224 |
| 87 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.24191114 |
| 88 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.23641421 |
| 89 | OCT4_20526341_ChIP-Seq_ESCs_Human | 1.23370753 |
| 90 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.22268637 |
| 91 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.22268487 |
| 92 | MYC_19829295_ChIP-Seq_ESCs_Human | 1.20831080 |
| 93 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 1.17899699 |
| 94 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.17830279 |
| 95 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.16933885 |
| 96 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 1.15801302 |
| 97 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 1.15620063 |
| 98 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.15057467 |
| 99 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.13011602 |
| 100 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.12233380 |
| 101 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.11987768 |
| 102 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.11569273 |
| 103 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.11412061 |
| 104 | WDR5_24793694_ChIP-Seq_LNCAP_Human | 1.11155211 |
| 105 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 1.10755690 |
| 106 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.10014184 |
| 107 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.08478575 |
| 108 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.08426779 |
| 109 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.08210021 |
| 110 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.07940680 |
| 111 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.07919882 |
| 112 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 1.07730934 |
| 113 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.05928147 |
| 114 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.05907525 |
| 115 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.05798557 |
| 116 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.05606837 |
| 117 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.05584464 |
| 118 | TDRD3_21172665_ChIP-Seq_MCF-7_Human | 1.05322519 |
| 119 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.04321838 |
| 120 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.04312744 |
| 121 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.02779483 |
| 122 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.02515302 |
| 123 | E2F1_20622854_ChIP-Seq_HELA_Human | 1.01258146 |
| 124 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.00463485 |
| 125 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.99914503 |
| 126 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.99823960 |
| 127 | RXR_22108803_ChIP-Seq_LS180_Human | 0.99664408 |
| 128 | P53_21459846_ChIP-Seq_SAOS-2_Human | 0.99649280 |
| 129 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 0.99601660 |
| 130 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.99537513 |
| 131 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.99423972 |
| 132 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 0.99035146 |
| 133 | OCT1_27270436_Chip-Seq_PROSTATE_Human | 0.98859646 |
| 134 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.98536375 |
| 135 | RAC3_21632823_ChIP-Seq_H3396_Human | 0.97907329 |
| 136 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.96957995 |
| 137 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.96819143 |
| 138 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.96819143 |
| 139 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.96416184 |
| 140 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.96027796 |
| 141 | KDM2B_26808549_Chip-Seq_REH_Human | 0.95810859 |
| 142 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.95279857 |
| 143 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 0.95134585 |
| 144 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.94471111 |
| 145 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.94177348 |
| 146 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.93627266 |
| 147 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.93401825 |
| 148 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.93317162 |
| 149 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.93214782 |
| 150 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.93166495 |
| 151 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.93166495 |
| 152 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 0.93010983 |
| 153 | RNF2_27304074_Chip-Seq_NSC_Mouse | 0.92712897 |
| 154 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.92047879 |
| 155 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.91910827 |
| 156 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.91022255 |
| 157 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.90891923 |
| 158 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.90567601 |
| 159 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.89988468 |
| 160 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.88496147 |
| 161 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.88176271 |
| 162 | EZH2_22144423_ChIP-Seq_EOC_Human | 0.87994871 |
| 163 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.87613125 |
| 164 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.87287061 |
| 165 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.86368082 |
| 166 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.86150360 |
| 167 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.85761781 |
| 168 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.84742410 |
| 169 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.81295813 |
| 170 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.80398260 |
| 171 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.79585444 |
| 172 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.79544748 |
| 173 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.77371716 |
| 174 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.76927360 |
| 175 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.76427815 |
| 176 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 0.76216701 |
| 177 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.76095104 |
| 178 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.73004785 |
| 179 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.72940271 |
| 180 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 0.72484899 |
| 181 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.70797276 |
| 182 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.70622443 |
| 183 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.69806814 |
| 184 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 0.69592977 |
| 185 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.69074811 |
| 186 | FUS_26573619_Chip-Seq_HEK293_Human | 0.68823533 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001529_abnormal_vocalization | 3.94195037 |
| 2 | MP0009379_abnormal_foot_pigmentation | 3.87395034 |
| 3 | MP0003880_abnormal_central_pattern | 3.46918401 |
| 4 | MP0003646_muscle_fatigue | 2.92450918 |
| 5 | MP0001905_abnormal_dopamine_level | 2.92283920 |
| 6 | MP0005377_hearing/vestibular/ear_phenot | 2.86893770 |
| 7 | MP0003878_abnormal_ear_physiology | 2.86893770 |
| 8 | MP0000569_abnormal_digit_pigmentation | 2.75949481 |
| 9 | MP0002736_abnormal_nociception_after | 2.61781728 |
| 10 | MP0003195_calcinosis | 2.44832816 |
| 11 | MP0005670_abnormal_white_adipose | 2.41985280 |
| 12 | MP0002638_abnormal_pupillary_reflex | 2.30441522 |
| 13 | MP0001968_abnormal_touch/_nociception | 2.28553319 |
| 14 | MP0001986_abnormal_taste_sensitivity | 2.23293907 |
| 15 | MP0002163_abnormal_gland_morphology | 2.19769281 |
| 16 | MP0006276_abnormal_autonomic_nervous | 2.12707998 |
| 17 | MP0004043_abnormal_pH_regulation | 2.00719941 |
| 18 | MP0000372_irregular_coat_pigmentation | 1.96347981 |
| 19 | MP0005423_abnormal_somatic_nervous | 1.94345158 |
| 20 | MP0006035_abnormal_mitochondrial_morpho | 1.91829263 |
| 21 | MP0001485_abnormal_pinna_reflex | 1.90099727 |
| 22 | MP0003186_abnormal_redox_activity | 1.89604428 |
| 23 | MP0005671_abnormal_response_to | 1.89052983 |
| 24 | MP0002272_abnormal_nervous_system | 1.88502231 |
| 25 | MP0004145_abnormal_muscle_electrophysio | 1.85716026 |
| 26 | MP0006036_abnormal_mitochondrial_physio | 1.84964512 |
| 27 | MP0002148_abnormal_hypersensitivity_rea | 1.83016113 |
| 28 | MP0001188_hyperpigmentation | 1.82894349 |
| 29 | MP0005645_abnormal_hypothalamus_physiol | 1.82437842 |
| 30 | MP0009745_abnormal_behavioral_response | 1.80386142 |
| 31 | MP0005379_endocrine/exocrine_gland_phen | 1.78716168 |
| 32 | MP0004142_abnormal_muscle_tone | 1.77259788 |
| 33 | MP0003724_increased_susceptibility_to | 1.73860831 |
| 34 | MP0002876_abnormal_thyroid_physiology | 1.73309590 |
| 35 | MP0002735_abnormal_chemical_nociception | 1.73264372 |
| 36 | MP0008789_abnormal_olfactory_epithelium | 1.71735969 |
| 37 | MP0010386_abnormal_urinary_bladder | 1.67094572 |
| 38 | MP0002064_seizures | 1.66226427 |
| 39 | MP0001984_abnormal_olfaction | 1.66155694 |
| 40 | MP0001835_abnormal_antigen_presentation | 1.64605473 |
| 41 | MP0006292_abnormal_olfactory_placode | 1.64461735 |
| 42 | MP0003698_abnormal_male_reproductive | 1.63663806 |
| 43 | MP0009785_altered_susceptibility_to | 1.58338389 |
| 44 | MP0005174_abnormal_tail_pigmentation | 1.53115996 |
| 45 | MP0005075_abnormal_melanosome_morpholog | 1.52616632 |
| 46 | MP0005083_abnormal_biliary_tract | 1.52392563 |
| 47 | MP0000015_abnormal_ear_pigmentation | 1.47889523 |
| 48 | MP0009046_muscle_twitch | 1.47468404 |
| 49 | MP0002928_abnormal_bile_duct | 1.46558130 |
| 50 | MP0008961_abnormal_basal_metabolism | 1.46388755 |
| 51 | MP0005167_abnormal_blood-brain_barrier | 1.46330690 |
| 52 | MP0005394_taste/olfaction_phenotype | 1.45906024 |
| 53 | MP0005499_abnormal_olfactory_system | 1.45906024 |
| 54 | MP0005084_abnormal_gallbladder_morpholo | 1.45161443 |
| 55 | MP0002572_abnormal_emotion/affect_behav | 1.44843530 |
| 56 | MP0004885_abnormal_endolymph | 1.43259343 |
| 57 | MP0005000_abnormal_immune_tolerance | 1.41644371 |
| 58 | MP0001970_abnormal_pain_threshold | 1.40291342 |
| 59 | MP0002938_white_spotting | 1.39318299 |
| 60 | MP0002837_dystrophic_cardiac_calcinosis | 1.35389645 |
| 61 | MP0008872_abnormal_physiological_respon | 1.32403260 |
| 62 | MP0003635_abnormal_synaptic_transmissio | 1.31201151 |
| 63 | MP0004130_abnormal_muscle_cell | 1.31152930 |
| 64 | MP0001929_abnormal_gametogenesis | 1.30098236 |
| 65 | MP0002734_abnormal_mechanical_nocicepti | 1.29242506 |
| 66 | MP0003045_fibrosis | 1.28512539 |
| 67 | MP0002653_abnormal_ependyma_morphology | 1.28031841 |
| 68 | MP0009333_abnormal_splenocyte_physiolog | 1.27767643 |
| 69 | MP0001501_abnormal_sleep_pattern | 1.25894084 |
| 70 | MP0000685_abnormal_immune_system | 1.25565193 |
| 71 | MP0003122_maternal_imprinting | 1.25054753 |
| 72 | MP0001348_abnormal_lacrimal_gland | 1.24363992 |
| 73 | MP0001963_abnormal_hearing_physiology | 1.21246382 |
| 74 | MP0005646_abnormal_pituitary_gland | 1.21108816 |
| 75 | MP0002132_abnormal_respiratory_system | 1.19486239 |
| 76 | MP0005253_abnormal_eye_physiology | 1.16519773 |
| 77 | MP0005408_hypopigmentation | 1.16403646 |
| 78 | MP0001800_abnormal_humoral_immune | 1.14901724 |
| 79 | MP0004147_increased_porphyrin_level | 1.14640001 |
| 80 | MP0005409_darkened_coat_color | 1.14515170 |
| 81 | MP0002063_abnormal_learning/memory/cond | 1.14411494 |
| 82 | MP0002822_catalepsy | 1.13847326 |
| 83 | MP0008877_abnormal_DNA_methylation | 1.12843971 |
| 84 | MP0002723_abnormal_immune_serum | 1.11445493 |
| 85 | MP0003787_abnormal_imprinting | 1.11114678 |
| 86 | MP0005025_abnormal_response_to | 1.11047135 |
| 87 | MP0002420_abnormal_adaptive_immunity | 1.10783515 |
| 88 | MP0002733_abnormal_thermal_nociception | 1.10342050 |
| 89 | MP0001440_abnormal_grooming_behavior | 1.10325435 |
| 90 | MP0003763_abnormal_thymus_physiology | 1.08225689 |
| 91 | MP0000427_abnormal_hair_cycle | 1.07032093 |
| 92 | MP0001819_abnormal_immune_cell | 1.06899024 |
| 93 | MP0004742_abnormal_vestibular_system | 1.05236519 |
| 94 | MP0000026_abnormal_inner_ear | 1.05221993 |
| 95 | MP0002398_abnormal_bone_marrow | 1.04465788 |
| 96 | MP0001765_abnormal_ion_homeostasis | 1.03186393 |
| 97 | MP0003866_abnormal_defecation | 1.01190019 |
| 98 | MP0003136_yellow_coat_color | 1.01099807 |
| 99 | MP0004133_heterotaxia | 1.00786110 |
| 100 | MP0002229_neurodegeneration | 0.99452407 |
| 101 | MP0005310_abnormal_salivary_gland | 0.97670066 |
| 102 | MP0005410_abnormal_fertilization | 0.95861751 |
| 103 | MP0000230_abnormal_systemic_arterial | 0.95369397 |
| 104 | MP0003656_abnormal_erythrocyte_physiolo | 0.95124504 |
| 105 | MP0003879_abnormal_hair_cell | 0.94081381 |
| 106 | MP0002095_abnormal_skin_pigmentation | 0.93876689 |
| 107 | MP0000716_abnormal_immune_system | 0.92645679 |
| 108 | MP0000631_abnormal_neuroendocrine_gland | 0.92598653 |
| 109 | MP0002452_abnormal_antigen_presenting | 0.91848048 |
| 110 | MP0002067_abnormal_sensory_capabilities | 0.91641606 |
| 111 | MP0004859_abnormal_synaptic_plasticity | 0.91522194 |
| 112 | MP0000470_abnormal_stomach_morphology | 0.91002165 |
| 113 | MP0001764_abnormal_homeostasis | 0.90982583 |
| 114 | MP0003436_decreased_susceptibility_to | 0.88759431 |
| 115 | MP0002138_abnormal_hepatobiliary_system | 0.88074883 |
| 116 | MP0001790_abnormal_immune_system | 0.87957321 |
| 117 | MP0005387_immune_system_phenotype | 0.87957321 |
| 118 | MP0008569_lethality_at_weaning | 0.87560068 |
| 119 | MP0005448_abnormal_energy_balance | 0.87406645 |
| 120 | MP0003137_abnormal_impulse_conducting | 0.85355467 |
| 121 | MP0002102_abnormal_ear_morphology | 0.85113795 |
| 122 | MP0004924_abnormal_behavior | 0.84953796 |
| 123 | MP0005386_behavior/neurological_phenoty | 0.84953796 |
| 124 | MP0001542_abnormal_bone_strength | 0.84614650 |
| 125 | MP0002429_abnormal_blood_cell | 0.83614161 |
| 126 | MP0002210_abnormal_sex_determination | 0.82928651 |
| 127 | MP0001853_heart_inflammation | 0.82821993 |
| 128 | MP0005636_abnormal_mineral_homeostasis | 0.82772212 |
| 129 | MP0000955_abnormal_spinal_cord | 0.81991626 |
| 130 | MP0008995_early_reproductive_senescence | 0.81744200 |
| 131 | MP0000465_gastrointestinal_hemorrhage | 0.81152973 |
| 132 | MP0003786_premature_aging | 0.80917983 |
| 133 | MP0006072_abnormal_retinal_apoptosis | 0.80877436 |
| 134 | MP0002752_abnormal_somatic_nervous | 0.80430495 |
| 135 | MP0002405_respiratory_system_inflammati | 0.80171389 |
| 136 | MP0005551_abnormal_eye_electrophysiolog | 0.79892906 |
| 137 | MP0001486_abnormal_startle_reflex | 0.79054226 |
| 138 | MP0002693_abnormal_pancreas_physiology | 0.78900551 |
| 139 | MP0002419_abnormal_innate_immunity | 0.78478425 |
| 140 | MP0002184_abnormal_innervation | 0.76144258 |
| 141 | MP0000689_abnormal_spleen_morphology | 0.75502227 |
| 142 | MP0002882_abnormal_neuron_morphology | 0.74965346 |
| 143 | MP0002722_abnormal_immune_system | 0.73951137 |
| 144 | MP0002751_abnormal_autonomic_nervous | 0.73641621 |
| 145 | MP0004085_abnormal_heartbeat | 0.72127189 |
| 146 | MP0004883_abnormal_blood_vessel | 0.71682612 |
| 147 | MP0002557_abnormal_social/conspecific_i | 0.71379110 |
| 148 | MP0000920_abnormal_myelination | 0.71332702 |
| 149 | MP0002168_other_aberrant_phenotype | 0.70646330 |
| 150 | MP0009764_decreased_sensitivity_to | 0.70532962 |
| 151 | MP0005195_abnormal_posterior_eye | 0.70166207 |
| 152 | MP0004270_analgesia | 0.69809280 |
| 153 | MP0002234_abnormal_pharynx_morphology | 0.69403593 |
| 154 | MP0008875_abnormal_xenobiotic_pharmacok | 0.69248247 |
| 155 | MP0003633_abnormal_nervous_system | 0.68523878 |
| 156 | MP0003693_abnormal_embryo_hatching | 0.68136519 |
| 157 | MP0005535_abnormal_body_temperature | 0.68134779 |
| 158 | MP0002161_abnormal_fertility/fecundity | 0.67921316 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 6.58070550 |
| 2 | Genetic anticipation (HP:0003743) | 6.05059757 |
| 3 | Mitochondrial inheritance (HP:0001427) | 5.89169198 |
| 4 | Abnormal mitochondria in muscle tissue (HP:0008316) | 5.86488758 |
| 5 | Progressive macrocephaly (HP:0004481) | 5.38221496 |
| 6 | Hepatocellular necrosis (HP:0001404) | 5.21265163 |
| 7 | Acute encephalopathy (HP:0006846) | 5.14719668 |
| 8 | Progressive cerebellar ataxia (HP:0002073) | 5.00697118 |
| 9 | Increased CSF lactate (HP:0002490) | 4.98882432 |
| 10 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.88352422 |
| 11 | Increased hepatocellular lipid droplets (HP:0006565) | 4.45213753 |
| 12 | Hepatic necrosis (HP:0002605) | 4.34456697 |
| 13 | Abnormal number of erythroid precursors (HP:0012131) | 4.33430316 |
| 14 | Congenital stationary night blindness (HP:0007642) | 4.18421970 |
| 15 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 4.17142290 |
| 16 | Renal Fanconi syndrome (HP:0001994) | 4.13299945 |
| 17 | Attenuation of retinal blood vessels (HP:0007843) | 4.03130132 |
| 18 | Abnormality of glycolysis (HP:0004366) | 3.87126559 |
| 19 | Increased serum pyruvate (HP:0003542) | 3.87126559 |
| 20 | Lipid accumulation in hepatocytes (HP:0006561) | 3.84408467 |
| 21 | Gaze-evoked nystagmus (HP:0000640) | 3.82328382 |
| 22 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.76995781 |
| 23 | Reticulocytopenia (HP:0001896) | 3.71500135 |
| 24 | 3-Methylglutaconic aciduria (HP:0003535) | 3.67231232 |
| 25 | Nephronophthisis (HP:0000090) | 3.65824009 |
| 26 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.60636517 |
| 27 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.60636517 |
| 28 | Exertional dyspnea (HP:0002875) | 3.55524122 |
| 29 | Optic disc pallor (HP:0000543) | 3.53032514 |
| 30 | Exercise intolerance (HP:0003546) | 3.51328998 |
| 31 | Respiratory failure (HP:0002878) | 3.43107877 |
| 32 | Abnormality of midbrain morphology (HP:0002418) | 3.38346853 |
| 33 | Molar tooth sign on MRI (HP:0002419) | 3.38346853 |
| 34 | Chronic hepatic failure (HP:0100626) | 3.36360056 |
| 35 | Bony spicule pigmentary retinopathy (HP:0007737) | 3.27165835 |
| 36 | Diplopia (HP:0000651) | 3.27131925 |
| 37 | Abnormality of binocular vision (HP:0011514) | 3.27131925 |
| 38 | Hypothermia (HP:0002045) | 3.25167408 |
| 39 | Decreased circulating renin level (HP:0003351) | 3.21953351 |
| 40 | Abnormality of the renal medulla (HP:0100957) | 3.21045497 |
| 41 | Lactic acidosis (HP:0003128) | 3.15447186 |
| 42 | Increased serum lactate (HP:0002151) | 3.14001734 |
| 43 | Increased intramyocellular lipid droplets (HP:0012240) | 3.13304514 |
| 44 | Decreased central vision (HP:0007663) | 3.12830250 |
| 45 | Abnormal drinking behavior (HP:0030082) | 3.11755619 |
| 46 | Polydipsia (HP:0001959) | 3.11755619 |
| 47 | Cerebral edema (HP:0002181) | 3.09159129 |
| 48 | Retinal dysplasia (HP:0007973) | 3.08042389 |
| 49 | Leukodystrophy (HP:0002415) | 3.08023610 |
| 50 | Absent/shortened dynein arms (HP:0200106) | 3.02640477 |
| 51 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 3.02640477 |
| 52 | Respiratory difficulties (HP:0002880) | 3.02222364 |
| 53 | Macrocytic anemia (HP:0001972) | 2.96609955 |
| 54 | Medial flaring of the eyebrow (HP:0010747) | 2.91320960 |
| 55 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 2.85477829 |
| 56 | Protruding tongue (HP:0010808) | 2.82751100 |
| 57 | Cystic liver disease (HP:0006706) | 2.82738665 |
| 58 | Sclerocornea (HP:0000647) | 2.79007967 |
| 59 | Abolished electroretinogram (ERG) (HP:0000550) | 2.78794341 |
| 60 | Pallor (HP:0000980) | 2.78536629 |
| 61 | Parakeratosis (HP:0001036) | 2.78038729 |
| 62 | Clumsiness (HP:0002312) | 2.77770104 |
| 63 | Hyperkalemia (HP:0002153) | 2.75989396 |
| 64 | Type I transferrin isoform profile (HP:0003642) | 2.74742975 |
| 65 | Abnormality of the renal cortex (HP:0011035) | 2.73742163 |
| 66 | Nephrogenic diabetes insipidus (HP:0009806) | 2.72318996 |
| 67 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.68622329 |
| 68 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.66896326 |
| 69 | Abnormality of renal resorption (HP:0011038) | 2.66711860 |
| 70 | Abnormal hair whorl (HP:0010721) | 2.66349053 |
| 71 | Type II lissencephaly (HP:0007260) | 2.66295480 |
| 72 | Gait imbalance (HP:0002141) | 2.65001518 |
| 73 | Congenital primary aphakia (HP:0007707) | 2.64279007 |
| 74 | Hypoplastic ischia (HP:0003175) | 2.63880167 |
| 75 | Tubular atrophy (HP:0000092) | 2.58060234 |
| 76 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 2.57904559 |
| 77 | Congenital sensorineural hearing impairment (HP:0008527) | 2.57141282 |
| 78 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.54117066 |
| 79 | Increased muscle lipid content (HP:0009058) | 2.52777918 |
| 80 | Myokymia (HP:0002411) | 2.50012436 |
| 81 | Polyuria (HP:0000103) | 2.43359874 |
| 82 | Febrile seizures (HP:0002373) | 2.40729122 |
| 83 | Abnormal ciliary motility (HP:0012262) | 2.37148412 |
| 84 | Large for gestational age (HP:0001520) | 2.36908078 |
| 85 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 2.36330184 |
| 86 | Inability to walk (HP:0002540) | 2.34441888 |
| 87 | Focal motor seizures (HP:0011153) | 2.31844543 |
| 88 | True hermaphroditism (HP:0010459) | 2.31517247 |
| 89 | Impaired smooth pursuit (HP:0007772) | 2.30697116 |
| 90 | Aplastic anemia (HP:0001915) | 2.29418876 |
| 91 | Broad-based gait (HP:0002136) | 2.28028464 |
| 92 | Abnormality of macular pigmentation (HP:0008002) | 2.24746791 |
| 93 | Postural instability (HP:0002172) | 2.23989293 |
| 94 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.21110081 |
| 95 | Emotional lability (HP:0000712) | 2.20361367 |
| 96 | Congenital hepatic fibrosis (HP:0002612) | 2.19931942 |
| 97 | X-linked dominant inheritance (HP:0001423) | 2.19378886 |
| 98 | Limb dystonia (HP:0002451) | 2.18865715 |
| 99 | Abnormality of the ischium (HP:0003174) | 2.13276567 |
| 100 | Abnormal urine output (HP:0012590) | 2.10221949 |
| 101 | Abnormal protein glycosylation (HP:0012346) | 2.09653606 |
| 102 | Abnormal glycosylation (HP:0012345) | 2.09653606 |
| 103 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.09653606 |
| 104 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.09653606 |
| 105 | Pendular nystagmus (HP:0012043) | 2.09459982 |
| 106 | Absent speech (HP:0001344) | 2.07241133 |
| 107 | Abnormality of alanine metabolism (HP:0010916) | 2.05872334 |
| 108 | Hyperalaninemia (HP:0003348) | 2.05872334 |
| 109 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.05872334 |
| 110 | CNS demyelination (HP:0007305) | 2.04429808 |
| 111 | Neuroendocrine neoplasm (HP:0100634) | 2.03661834 |
| 112 | Cerebellar dysplasia (HP:0007033) | 2.03533223 |
| 113 | Abnormality of potassium homeostasis (HP:0011042) | 2.01906637 |
| 114 | Pancreatic fibrosis (HP:0100732) | 2.01159253 |
| 115 | Reduced antithrombin III activity (HP:0001976) | 2.00397146 |
| 116 | Poor suck (HP:0002033) | 2.00366486 |
| 117 | Patellar aplasia (HP:0006443) | 1.99205001 |
| 118 | Anencephaly (HP:0002323) | 1.99197610 |
| 119 | Hypoplasia of the pons (HP:0012110) | 1.97741766 |
| 120 | Urinary bladder sphincter dysfunction (HP:0002839) | 1.97592380 |
| 121 | Abnormal respiratory motile cilium physiology (HP:0012261) | 1.97293159 |
| 122 | Keratoconus (HP:0000563) | 1.96933002 |
| 123 | Increased corneal curvature (HP:0100692) | 1.96933002 |
| 124 | Abnormality of renin-angiotensin system (HP:0000847) | 1.96583762 |
| 125 | Bulbous nose (HP:0000414) | 1.92059574 |
| 126 | Amniotic constriction ring (HP:0009775) | 1.91858171 |
| 127 | Abnormality of placental membranes (HP:0011409) | 1.91858171 |
| 128 | Abnormality of the renal collecting system (HP:0004742) | 1.90535394 |
| 129 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.90140672 |
| 130 | Widely spaced teeth (HP:0000687) | 1.89613367 |
| 131 | Dysmetric saccades (HP:0000641) | 1.89528955 |
| 132 | Severe visual impairment (HP:0001141) | 1.89414447 |
| 133 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.88966110 |
| 134 | Palpebral edema (HP:0100540) | 1.88223594 |
| 135 | Abnormality of the pons (HP:0007361) | 1.86466921 |
| 136 | Macular degeneration (HP:0000608) | 1.86056564 |
| 137 | Focal seizures (HP:0007359) | 1.85946889 |
| 138 | Congenital ichthyosiform erythroderma (HP:0007431) | 1.85894619 |
| 139 | Tubulointerstitial nephritis (HP:0001970) | 1.84178216 |
| 140 | Cerebral hypomyelination (HP:0006808) | 1.83691511 |
| 141 | Vaginal atresia (HP:0000148) | 1.83401757 |
| 142 | Lissencephaly (HP:0001339) | 1.82023381 |
| 143 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.81847652 |
| 144 | IgM deficiency (HP:0002850) | 1.81357346 |
| 145 | Chorioretinal atrophy (HP:0000533) | 1.81213564 |
| 146 | Renal tubular dysfunction (HP:0000124) | 1.81197654 |
| 147 | Dialeptic seizures (HP:0011146) | 1.79606146 |
| 148 | Abnormality of renal excretion (HP:0011036) | 1.79354300 |
| 149 | Ectopic kidney (HP:0000086) | 1.77889260 |
| 150 | Thrombocytosis (HP:0001894) | 1.77797255 |
| 151 | Abnormality of the pubic bones (HP:0003172) | 1.76922036 |
| 152 | Male pseudohermaphroditism (HP:0000037) | 1.76743243 |
| 153 | Genital tract atresia (HP:0001827) | 1.76536241 |
| 154 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.76523971 |
| 155 | Hemiparesis (HP:0001269) | 1.76513236 |
| 156 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 1.76051677 |
| 157 | Amelogenesis imperfecta (HP:0000705) | 1.76042011 |
| 158 | Furrowed tongue (HP:0000221) | 1.75497768 |
| 159 | Progressive inability to walk (HP:0002505) | 1.73631297 |
| 160 | Pheochromocytoma (HP:0002666) | 1.72289315 |
| 161 | Absence seizures (HP:0002121) | 1.70566889 |
| 162 | Poor coordination (HP:0002370) | 1.69451778 |
| 163 | Hyperventilation (HP:0002883) | 1.68259568 |
| 164 | Abnormality of ocular smooth pursuit (HP:0000617) | 1.68134242 |
| 165 | Pancreatic cysts (HP:0001737) | 1.67968959 |
| 166 | Petechiae (HP:0000967) | 1.67674826 |
| 167 | Prolonged QT interval (HP:0001657) | 1.67560640 |
| 168 | Neutropenia (HP:0001875) | 1.67430525 |
| 169 | IgG deficiency (HP:0004315) | 1.66783041 |
| 170 | Hyperphosphaturia (HP:0003109) | 1.65767655 |
| 171 | Delusions (HP:0000746) | 1.63323539 |
| 172 | Microvesicular hepatic steatosis (HP:0001414) | 1.62699723 |
| 173 | Aplasia/Hypoplasia of the lens (HP:0008063) | 1.61848909 |
| 174 | Methylmalonic aciduria (HP:0012120) | 1.61481270 |
| 175 | Irregular epiphyses (HP:0010582) | 1.58648534 |
| 176 | Abnormal respiratory epithelium morphology (HP:0012253) | 1.57918732 |
| 177 | Abnormal respiratory motile cilium morphology (HP:0005938) | 1.57918732 |
| 178 | Glycosuria (HP:0003076) | 1.56966424 |
| 179 | Abnormality of urine glucose concentration (HP:0011016) | 1.56966424 |
| 180 | 11 pairs of ribs (HP:0000878) | 1.55737645 |
| 181 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.55284565 |
| 182 | Polyphagia (HP:0002591) | 1.54800320 |
| 183 | Redundant skin (HP:0001582) | 1.54759467 |
| 184 | Birth length less than 3rd percentile (HP:0003561) | 1.54177213 |
| 185 | Chronic sinusitis (HP:0011109) | 1.53940053 |
| 186 | Epileptic encephalopathy (HP:0200134) | 1.53799506 |
| 187 | Atonic seizures (HP:0010819) | 1.53750435 |
| 188 | Blindness (HP:0000618) | 1.53081944 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FRK | 7.58584080 |
| 2 | MAP3K12 | 4.50793106 |
| 3 | INSRR | 3.61142200 |
| 4 | STK16 | 3.55388336 |
| 5 | SIK2 | 3.15587739 |
| 6 | NME2 | 2.80234139 |
| 7 | NME1 | 2.78794693 |
| 8 | MST4 | 2.59975540 |
| 9 | CASK | 2.51579047 |
| 10 | ACVR1B | 2.48830658 |
| 11 | PIM2 | 2.43949519 |
| 12 | VRK1 | 2.29659026 |
| 13 | MAP4K2 | 2.22913894 |
| 14 | TESK2 | 2.21223285 |
| 15 | BUB1 | 2.15073561 |
| 16 | CDK19 | 2.09857013 |
| 17 | MAP2K7 | 2.00265030 |
| 18 | DAPK2 | 1.99391663 |
| 19 | WNK4 | 1.96035079 |
| 20 | RIPK4 | 1.93740978 |
| 21 | SIK3 | 1.91417197 |
| 22 | ARAF | 1.88083893 |
| 23 | MAPKAPK5 | 1.86235081 |
| 24 | MYLK | 1.75726040 |
| 25 | CAMK1D | 1.73896119 |
| 26 | LIMK1 | 1.73453739 |
| 27 | GRK1 | 1.67922784 |
| 28 | BMPR2 | 1.66338907 |
| 29 | CAMK1G | 1.61790291 |
| 30 | EIF2AK3 | 1.60014471 |
| 31 | TAOK3 | 1.58997224 |
| 32 | EIF2AK1 | 1.53596522 |
| 33 | MAPK15 | 1.50776464 |
| 34 | PLK2 | 1.49382999 |
| 35 | ZAK | 1.49151566 |
| 36 | PINK1 | 1.47164085 |
| 37 | TSSK6 | 1.35878914 |
| 38 | STK38 | 1.33781995 |
| 39 | GRK5 | 1.33643051 |
| 40 | WNK3 | 1.31761273 |
| 41 | ADRBK2 | 1.30349983 |
| 42 | TNK2 | 1.30187572 |
| 43 | CAMKK2 | 1.25171326 |
| 44 | CDK8 | 1.24428750 |
| 45 | BCR | 1.23719888 |
| 46 | ERBB3 | 1.23555465 |
| 47 | BLK | 1.22506658 |
| 48 | TESK1 | 1.21272982 |
| 49 | NUAK1 | 1.18657422 |
| 50 | TEC | 1.18358542 |
| 51 | PTK2B | 1.17538909 |
| 52 | BRAF | 1.16798268 |
| 53 | ILK | 1.15392095 |
| 54 | AKT3 | 1.14822419 |
| 55 | SYK | 1.12988615 |
| 56 | CCNB1 | 1.12357394 |
| 57 | MAPK13 | 1.12024202 |
| 58 | TNIK | 1.09987688 |
| 59 | TXK | 1.09922388 |
| 60 | BMPR1B | 1.08422136 |
| 61 | CAMK1 | 1.06261668 |
| 62 | CAMKK1 | 1.05331409 |
| 63 | KIT | 1.02438345 |
| 64 | DYRK2 | 1.02101640 |
| 65 | MAP2K6 | 1.01420009 |
| 66 | GRK6 | 0.97834447 |
| 67 | DDR2 | 0.95492758 |
| 68 | DAPK1 | 0.93672713 |
| 69 | PRKD3 | 0.90960877 |
| 70 | TIE1 | 0.87854310 |
| 71 | MARK3 | 0.87780581 |
| 72 | BCKDK | 0.86297274 |
| 73 | PRKCE | 0.85029383 |
| 74 | CSNK1G3 | 0.84812855 |
| 75 | PBK | 0.84795486 |
| 76 | YES1 | 0.84285997 |
| 77 | PHKG2 | 0.83354111 |
| 78 | PHKG1 | 0.83354111 |
| 79 | SRPK1 | 0.82593947 |
| 80 | WNK1 | 0.82310853 |
| 81 | MAP3K7 | 0.81178770 |
| 82 | PRKCG | 0.81133423 |
| 83 | PASK | 0.80704640 |
| 84 | ABL2 | 0.75812489 |
| 85 | GRK7 | 0.74986101 |
| 86 | NEK2 | 0.73346838 |
| 87 | STK11 | 0.72303425 |
| 88 | PRKAA2 | 0.71992513 |
| 89 | PNCK | 0.71489338 |
| 90 | MAP3K4 | 0.71177618 |
| 91 | OXSR1 | 0.71089672 |
| 92 | IRAK1 | 0.70585674 |
| 93 | PRKCH | 0.69564343 |
| 94 | PRKAA1 | 0.67978511 |
| 95 | CAMK2B | 0.67876620 |
| 96 | CAMK4 | 0.67326248 |
| 97 | KDR | 0.67062103 |
| 98 | UHMK1 | 0.66834955 |
| 99 | MUSK | 0.65022118 |
| 100 | STK39 | 0.64698060 |
| 101 | ADRBK1 | 0.64269414 |
| 102 | MARK2 | 0.62568872 |
| 103 | RAF1 | 0.62543430 |
| 104 | PAK1 | 0.61843779 |
| 105 | CHUK | 0.61333687 |
| 106 | PAK3 | 0.61229283 |
| 107 | PLK3 | 0.60994204 |
| 108 | TYRO3 | 0.59953375 |
| 109 | NTRK3 | 0.59701428 |
| 110 | MKNK1 | 0.58925131 |
| 111 | BRSK1 | 0.58666679 |
| 112 | RPS6KA6 | 0.58513851 |
| 113 | CDK18 | 0.56733606 |
| 114 | WEE1 | 0.56517802 |
| 115 | PLK4 | 0.55719065 |
| 116 | OBSCN | 0.55621782 |
| 117 | TLK1 | 0.55216178 |
| 118 | PRKD2 | 0.54803120 |
| 119 | ZAP70 | 0.54544691 |
| 120 | PIK3CA | 0.54168571 |
| 121 | PDK1 | 0.53321996 |
| 122 | TYK2 | 0.53138148 |
| 123 | BTK | 0.51990347 |
| 124 | CDK11A | 0.51711020 |
| 125 | LYN | 0.51686082 |
| 126 | IRAK4 | 0.51640671 |
| 127 | MAPK4 | 0.51495387 |
| 128 | EPHA4 | 0.51165279 |
| 129 | CAMK2A | 0.50202807 |
| 130 | TGFBR1 | 0.50030289 |
| 131 | ITK | 0.49635720 |
| 132 | PRPF4B | 0.49478017 |
| 133 | DAPK3 | 0.48982277 |
| 134 | CSNK2A1 | 0.48489357 |
| 135 | MAP4K1 | 0.48210800 |
| 136 | ROCK2 | 0.47757000 |
| 137 | PIK3CG | 0.47670676 |
| 138 | CDK15 | 0.47622228 |
| 139 | TAOK1 | 0.47528508 |
| 140 | BRSK2 | 0.46779458 |
| 141 | LRRK2 | 0.46750981 |
| 142 | FES | 0.46737803 |
| 143 | PRKCZ | 0.46724472 |
| 144 | MAPKAPK3 | 0.46390844 |
| 145 | IKBKB | 0.45753011 |
| 146 | MINK1 | 0.45295239 |
| 147 | CDK14 | 0.44992467 |
| 148 | STK38L | 0.44054171 |
| 149 | MAP3K14 | 0.43946196 |
| 150 | SGK2 | 0.43847209 |
| 151 | PRKCQ | 0.43442254 |
| 152 | LCK | 0.43177142 |
| 153 | PRKG1 | 0.42836341 |
| 154 | MARK1 | 0.42484550 |
| 155 | SGK223 | 0.40212958 |
| 156 | SGK494 | 0.40212958 |
| 157 | RPS6KA5 | 0.40209389 |
| 158 | MAP3K11 | 0.39907823 |
| 159 | CSNK2A2 | 0.39871207 |
| 160 | SGK1 | 0.39182405 |
| 161 | PKN1 | 0.38160945 |
| 162 | AURKA | 0.38108490 |
| 163 | TRPM7 | 0.38046967 |
| 164 | NTRK2 | 0.37970622 |
| 165 | PRKCA | 0.37850598 |
| 166 | DYRK3 | 0.37840824 |
| 167 | PRKACA | 0.37659892 |
| 168 | PDPK1 | 0.36312858 |
| 169 | MKNK2 | 0.35723792 |
| 170 | MAP2K4 | 0.35646544 |
| 171 | MAPK11 | 0.34841484 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 5.44438481 |
| 2 | Ribosome_Homo sapiens_hsa03010 | 5.30046962 |
| 3 | Parkinsons disease_Homo sapiens_hsa05012 | 4.67988436 |
| 4 | Proteasome_Homo sapiens_hsa03050 | 4.52896373 |
| 5 | Alzheimers disease_Homo sapiens_hsa05010 | 3.43966434 |
| 6 | Huntingtons disease_Homo sapiens_hsa05016 | 3.30863295 |
| 7 | RNA polymerase_Homo sapiens_hsa03020 | 3.21733606 |
| 8 | Protein export_Homo sapiens_hsa03060 | 3.12807183 |
| 9 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.80943076 |
| 10 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.17876908 |
| 11 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 2.15498765 |
| 12 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.93727288 |
| 13 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.91513588 |
| 14 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.86378808 |
| 15 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.86317053 |
| 16 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.85608342 |
| 17 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.81090183 |
| 18 | ABC transporters_Homo sapiens_hsa02010 | 1.79254452 |
| 19 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.66991551 |
| 20 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.66073291 |
| 21 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.56797928 |
| 22 | Insulin secretion_Homo sapiens_hsa04911 | 1.56653629 |
| 23 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.55075220 |
| 24 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.51922743 |
| 25 | DNA replication_Homo sapiens_hsa03030 | 1.51043729 |
| 26 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.47528770 |
| 27 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.44845740 |
| 28 | Spliceosome_Homo sapiens_hsa03040 | 1.35284700 |
| 29 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.33418314 |
| 30 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.29204861 |
| 31 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 1.27907271 |
| 32 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.24075699 |
| 33 | Purine metabolism_Homo sapiens_hsa00230 | 1.23558888 |
| 34 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 1.22721800 |
| 35 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.22653395 |
| 36 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.20982864 |
| 37 | Mismatch repair_Homo sapiens_hsa03430 | 1.20936295 |
| 38 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.20727727 |
| 39 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.18346384 |
| 40 | Basal transcription factors_Homo sapiens_hsa03022 | 1.17568333 |
| 41 | Nicotine addiction_Homo sapiens_hsa05033 | 1.14248767 |
| 42 | Salivary secretion_Homo sapiens_hsa04970 | 1.11041641 |
| 43 | Homologous recombination_Homo sapiens_hsa03440 | 1.08474130 |
| 44 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.05949348 |
| 45 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.05926210 |
| 46 | Lysine degradation_Homo sapiens_hsa00310 | 1.05392623 |
| 47 | Base excision repair_Homo sapiens_hsa03410 | 1.05112330 |
| 48 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.03585903 |
| 49 | Allograft rejection_Homo sapiens_hsa05330 | 1.03507940 |
| 50 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.03203676 |
| 51 | RNA degradation_Homo sapiens_hsa03018 | 0.97727501 |
| 52 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.97174999 |
| 53 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.96205631 |
| 54 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.95766787 |
| 55 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.94131354 |
| 56 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.93213711 |
| 57 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.92722168 |
| 58 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.92537693 |
| 59 | Phototransduction_Homo sapiens_hsa04744 | 0.90994854 |
| 60 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.89477119 |
| 61 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.85387988 |
| 62 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.83437120 |
| 63 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.82304993 |
| 64 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.82022999 |
| 65 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.81706547 |
| 66 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.78876247 |
| 67 | Phagosome_Homo sapiens_hsa04145 | 0.77707678 |
| 68 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.76686135 |
| 69 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.76643775 |
| 70 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.75652105 |
| 71 | Sulfur relay system_Homo sapiens_hsa04122 | 0.75460578 |
| 72 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.74619415 |
| 73 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.72463560 |
| 74 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.71300650 |
| 75 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.69244373 |
| 76 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.69238436 |
| 77 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.68353635 |
| 78 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.66944998 |
| 79 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.66700404 |
| 80 | Retinol metabolism_Homo sapiens_hsa00830 | 0.65562903 |
| 81 | Taste transduction_Homo sapiens_hsa04742 | 0.65431719 |
| 82 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.64843752 |
| 83 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.64019241 |
| 84 | Metabolic pathways_Homo sapiens_hsa01100 | 0.63366077 |
| 85 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.62169783 |
| 86 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.61291135 |
| 87 | Long-term depression_Homo sapiens_hsa04730 | 0.58809609 |
| 88 | Renin secretion_Homo sapiens_hsa04924 | 0.56012935 |
| 89 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.55013584 |
| 90 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.54596251 |
| 91 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.53828346 |
| 92 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.53366522 |
| 93 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.52984047 |
| 94 | RNA transport_Homo sapiens_hsa03013 | 0.48052603 |
| 95 | Peroxisome_Homo sapiens_hsa04146 | 0.47708230 |
| 96 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.47609162 |
| 97 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.44602286 |
| 98 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.44132976 |
| 99 | Morphine addiction_Homo sapiens_hsa05032 | 0.43408483 |
| 100 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.43131477 |
| 101 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.42642230 |
| 102 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.42147743 |
| 103 | GABAergic synapse_Homo sapiens_hsa04727 | 0.41453673 |
| 104 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.41427829 |
| 105 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.40794612 |
| 106 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.40774553 |
| 107 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.40521707 |
| 108 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.39945432 |
| 109 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.39173645 |
| 110 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.38454251 |
| 111 | Circadian rhythm_Homo sapiens_hsa04710 | 0.36932490 |
| 112 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.36278822 |
| 113 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.36177653 |
| 114 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.36059040 |
| 115 | Olfactory transduction_Homo sapiens_hsa04740 | 0.35430061 |
| 116 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.35403487 |
| 117 | Mineral absorption_Homo sapiens_hsa04978 | 0.35241332 |
| 118 | Platelet activation_Homo sapiens_hsa04611 | 0.34380219 |
| 119 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.34188532 |
| 120 | Asthma_Homo sapiens_hsa05310 | 0.33958659 |
| 121 | Histidine metabolism_Homo sapiens_hsa00340 | 0.33894021 |
| 122 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.33502023 |
| 123 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.33318036 |
| 124 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.32536312 |
| 125 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.32529495 |
| 126 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.32370313 |
| 127 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.32113682 |
| 128 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.31854539 |
| 129 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.30961218 |
| 130 | Alcoholism_Homo sapiens_hsa05034 | 0.30829814 |
| 131 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.30779489 |
| 132 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.30422931 |
| 133 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.30014336 |
| 134 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.26622948 |
| 135 | Legionellosis_Homo sapiens_hsa05134 | 0.25829038 |
| 136 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.25015010 |
| 137 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.23363827 |
| 138 | Circadian entrainment_Homo sapiens_hsa04713 | 0.23032265 |
| 139 | Galactose metabolism_Homo sapiens_hsa00052 | 0.22697526 |
| 140 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.21471669 |
| 141 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.20263338 |
| 142 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.19580065 |
| 143 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.19052006 |
| 144 | Measles_Homo sapiens_hsa05162 | 0.17362780 |
| 145 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.16835836 |
| 146 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.16539612 |
| 147 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.16317339 |
| 148 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.15590362 |
| 149 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.15247511 |
| 150 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.15119871 |
| 151 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.14340991 |
| 152 | Leishmaniasis_Homo sapiens_hsa05140 | 0.13279699 |
| 153 | Cocaine addiction_Homo sapiens_hsa05030 | 0.12580555 |

