BORCS8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.57951713
2ATP synthesis coupled proton transport (GO:0015986)7.24923547
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.24923547
4ribosomal small subunit biogenesis (GO:0042274)5.94834765
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.81701059
6ribosomal small subunit assembly (GO:0000028)5.73425264
7viral transcription (GO:0019083)5.67684833
8chaperone-mediated protein transport (GO:0072321)5.51529337
9translational termination (GO:0006415)5.36265478
10respiratory electron transport chain (GO:0022904)5.36118021
11protein neddylation (GO:0045116)5.31299133
12electron transport chain (GO:0022900)5.25652093
13cotranslational protein targeting to membrane (GO:0006613)5.13467588
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.12166286
15protein targeting to ER (GO:0045047)5.03832958
16sperm motility (GO:0030317)4.94084808
17behavioral response to nicotine (GO:0035095)4.88423098
18protein localization to endoplasmic reticulum (GO:0070972)4.84364765
19establishment of protein localization to endoplasmic reticulum (GO:0072599)4.75700056
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.73405991
21mitochondrial respiratory chain complex I assembly (GO:0032981)4.73405991
22NADH dehydrogenase complex assembly (GO:0010257)4.73405991
23maturation of SSU-rRNA (GO:0030490)4.71562331
24protein complex biogenesis (GO:0070271)4.64522427
25translational elongation (GO:0006414)4.62405211
26regulation of female gonad development (GO:2000194)4.60506165
27cellular ketone body metabolic process (GO:0046950)4.49113250
28negative regulation of translation, ncRNA-mediated (GO:0040033)4.43039475
29regulation of translation, ncRNA-mediated (GO:0045974)4.43039475
30negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.43039475
31cellular protein complex disassembly (GO:0043624)4.38988272
32viral life cycle (GO:0019058)4.31939662
33mitochondrial respiratory chain complex assembly (GO:0033108)4.23435970
34cilium or flagellum-dependent cell motility (GO:0001539)4.22967386
35regulation of sarcomere organization (GO:0060297)4.22028555
36protein polyglutamylation (GO:0018095)4.21764478
37proteasome assembly (GO:0043248)4.19307838
38acrosome reaction (GO:0007340)4.16200294
39tryptophan catabolic process (GO:0006569)4.11281663
40indole-containing compound catabolic process (GO:0042436)4.11281663
41indolalkylamine catabolic process (GO:0046218)4.11281663
42GTP biosynthetic process (GO:0006183)4.06132144
43ketone body metabolic process (GO:1902224)4.02455468
44translation (GO:0006412)3.98676917
45NAD biosynthetic process (GO:0009435)3.95816373
46establishment of protein localization to mitochondrial membrane (GO:0090151)3.95471165
47nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.91744304
48kynurenine metabolic process (GO:0070189)3.88730640
49oxidative phosphorylation (GO:0006119)3.88247618
50translational initiation (GO:0006413)3.86664472
51detection of light stimulus involved in sensory perception (GO:0050962)3.80392355
52detection of light stimulus involved in visual perception (GO:0050908)3.80392355
53response to misfolded protein (GO:0051788)3.79969653
54antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.78081694
55purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.76376856
56indolalkylamine metabolic process (GO:0006586)3.76281777
57regulation of cellular amino acid metabolic process (GO:0006521)3.75457022
58dopamine transport (GO:0015872)3.75226274
59negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.72018186
60sequestering of actin monomers (GO:0042989)3.71825735
61protein complex disassembly (GO:0043241)3.71194022
62transcription elongation from RNA polymerase III promoter (GO:0006385)3.71166532
63termination of RNA polymerase III transcription (GO:0006386)3.71166532
64purine nucleoside triphosphate biosynthetic process (GO:0009145)3.68261794
65ATP biosynthetic process (GO:0006754)3.67875345
667-methylguanosine mRNA capping (GO:0006370)3.65623731
67G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.64484924
68RNA capping (GO:0036260)3.60716959
697-methylguanosine RNA capping (GO:0009452)3.60716959
70DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.59855170
71positive regulation of protein homodimerization activity (GO:0090073)3.59645111
72macromolecular complex disassembly (GO:0032984)3.59224327
73guanosine-containing compound biosynthetic process (GO:1901070)3.58731482
74multicellular organism reproduction (GO:0032504)3.57145986
75response to pheromone (GO:0019236)3.55891971
76membrane depolarization during action potential (GO:0086010)3.54281549
77antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.52886445
78cullin deneddylation (GO:0010388)3.51177282
79respiratory chain complex IV assembly (GO:0008535)3.50850347
80signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.50265876
81intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.50265876
82hydrogen ion transmembrane transport (GO:1902600)3.49343921
83negative regulation of ligase activity (GO:0051352)3.47098007
84negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.47098007
85protein K48-linked deubiquitination (GO:0071108)3.47047015
86inner mitochondrial membrane organization (GO:0007007)3.46515666
87signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.45650828
88signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.45650828
89signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.45650828
90tryptophan metabolic process (GO:0006568)3.45162334
91ribonucleoside triphosphate biosynthetic process (GO:0009201)3.43408262
92calcium ion-dependent exocytosis (GO:0017156)3.42511740
93ribosomal large subunit biogenesis (GO:0042273)3.40574852
94UTP biosynthetic process (GO:0006228)3.39000524
95L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.37434576
96protein targeting to membrane (GO:0006612)3.37210592
97L-fucose catabolic process (GO:0042355)3.32108574
98fucose catabolic process (GO:0019317)3.32108574
99L-fucose metabolic process (GO:0042354)3.32108574
100protein targeting to mitochondrion (GO:0006626)3.31757937
101establishment of integrated proviral latency (GO:0075713)3.31722880
102signal transduction involved in DNA integrity checkpoint (GO:0072401)3.30615874
103signal transduction involved in DNA damage checkpoint (GO:0072422)3.30615874
104CTP metabolic process (GO:0046036)3.30506550
105CTP biosynthetic process (GO:0006241)3.30506550
106DNA deamination (GO:0045006)3.30248205
107positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.30229784
108protein deneddylation (GO:0000338)3.29904724
109regulation of cilium movement (GO:0003352)3.29802459
110establishment of protein localization to Golgi (GO:0072600)3.27846746
111axoneme assembly (GO:0035082)3.27690222
112signal transduction involved in cell cycle checkpoint (GO:0072395)3.27359764
113fusion of sperm to egg plasma membrane (GO:0007342)3.22422458
114aerobic respiration (GO:0009060)3.22003182
115establishment of protein localization to mitochondrion (GO:0072655)3.20445016
116positive regulation of CREB transcription factor activity (GO:0032793)3.19759342
117monoubiquitinated protein deubiquitination (GO:0035520)3.19201822
118cytochrome complex assembly (GO:0017004)3.16076934
119proton transport (GO:0015992)3.15199286
120regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.12099726
121nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.11533774
122deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.10424162
123cellular biogenic amine catabolic process (GO:0042402)3.09328122
124amine catabolic process (GO:0009310)3.09328122
125hydrogen transport (GO:0006818)3.08402936
126gamma-aminobutyric acid transport (GO:0015812)3.06500320
127reflex (GO:0060004)3.06119509
128membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.05869354
129nucleoside triphosphate biosynthetic process (GO:0009142)3.05439382
130establishment of viral latency (GO:0019043)3.04768432
131regulation of cellular amine metabolic process (GO:0033238)3.04309981
132epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.04296187
133exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.01475420
134iron-sulfur cluster assembly (GO:0016226)3.01325780
135metallo-sulfur cluster assembly (GO:0031163)3.01325780
136spermatid development (GO:0007286)3.00895278
137cellular component biogenesis (GO:0044085)2.98850811
138peptidyl-threonine dephosphorylation (GO:0035970)2.98601192
139protein localization to mitochondrion (GO:0070585)2.97704781
140signal peptide processing (GO:0006465)2.96094975
141pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.95641972
142protein K63-linked deubiquitination (GO:0070536)2.95619539
143anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.94491236
144regulation of oxidative phosphorylation (GO:0002082)2.94226415
145pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.94225223
146nuclear-transcribed mRNA catabolic process (GO:0000956)2.93064736
147nicotinamide nucleotide biosynthetic process (GO:0019359)2.92413990
148pyridine nucleotide biosynthetic process (GO:0019363)2.92413990
149striated muscle atrophy (GO:0014891)2.92200966
150cAMP catabolic process (GO:0006198)2.90942537
151primary amino compound metabolic process (GO:1901160)2.89658401
152multicellular organismal movement (GO:0050879)2.89527828
153musculoskeletal movement (GO:0050881)2.89527828
154indole-containing compound metabolic process (GO:0042430)2.88894195
155phosphatidylethanolamine biosynthetic process (GO:0006646)2.88145861
156epithelial cilium movement (GO:0003351)2.88098008
157tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.87634763
158motile cilium assembly (GO:0044458)2.85673571
159cilium movement (GO:0003341)2.83619841
160detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.76709682
161skeletal muscle adaptation (GO:0043501)2.75375183
162spinal cord motor neuron differentiation (GO:0021522)2.73966106
163axonemal dynein complex assembly (GO:0070286)2.73722231
164regulation of skeletal muscle contraction (GO:0014819)2.72049358
165regulation of hippo signaling (GO:0035330)2.70976400
166calcium ion import (GO:0070509)2.69681961
167phosphatidylethanolamine metabolic process (GO:0046337)2.67838799
168regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.66418648
169positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.66418648
170neuronal action potential (GO:0019228)2.64101969
171regulation of Rab GTPase activity (GO:0032313)2.61993696
172positive regulation of Rab GTPase activity (GO:0032851)2.61993696
173negative regulation of systemic arterial blood pressure (GO:0003085)2.61025831
174response to gravity (GO:0009629)2.60497117
175alanine transport (GO:0032328)2.60350425
176cyclic nucleotide catabolic process (GO:0009214)2.59651625
177nonmotile primary cilium assembly (GO:0035058)2.58205085
178interkinetic nuclear migration (GO:0022027)2.57625593
179DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.56913615
180microtubule severing (GO:0051013)2.54732614
181cellular potassium ion transport (GO:0071804)2.54103789
182potassium ion transmembrane transport (GO:0071805)2.54103789
183organic cation transport (GO:0015695)2.53805157
184serotonin metabolic process (GO:0042428)2.53315136
185sulfation (GO:0051923)2.53295550
186negative regulation of cAMP-mediated signaling (GO:0043951)2.53151455
187microtubule polymerization or depolymerization (GO:0031109)2.52065803
188plasma membrane fusion (GO:0045026)2.51085297
189auditory receptor cell stereocilium organization (GO:0060088)2.50257414
190cilium organization (GO:0044782)2.50007761
191negative regulation of Rho protein signal transduction (GO:0035024)2.49571642
192misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.48895138
193reproduction (GO:0000003)2.47997482
194regulation of action potential (GO:0098900)2.47281239
195microtubule depolymerization (GO:0007019)2.46393154
196protein targeting to Golgi (GO:0000042)2.46321102
197sperm capacitation (GO:0048240)2.46129806
198dendritic spine morphogenesis (GO:0060997)2.46035966
199cilium assembly (GO:0042384)2.45819287

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.12961534
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.75148779
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.40850469
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.34498009
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.01457313
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.76802705
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.50584805
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.49574170
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.45475618
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.45172841
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.21707874
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.16713509
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.94015513
14ZNF274_21170338_ChIP-Seq_K562_Hela2.83972644
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.83871786
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.75236244
17DROSHA_22980978_ChIP-Seq_HELA_Human2.74095664
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.60971349
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.60521773
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.58779364
21VDR_23849224_ChIP-Seq_CD4+_Human2.51716391
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.51448606
23YY1_21170310_ChIP-Seq_MESCs_Mouse2.42849905
24THAP11_20581084_ChIP-Seq_MESCs_Mouse2.34973992
25CTBP2_25329375_ChIP-Seq_LNCAP_Human2.30202889
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.29409657
27ELK1_19687146_ChIP-ChIP_HELA_Human2.26684129
28DCP1A_22483619_ChIP-Seq_HELA_Human2.25501845
29CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.22671606
30FOXP3_21729870_ChIP-Seq_TREG_Human2.18798674
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.18725731
32GBX2_23144817_ChIP-Seq_PC3_Human2.13291573
33CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01408473
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.00353762
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.99189847
36XRN2_22483619_ChIP-Seq_HELA_Human1.96549546
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.94520431
38MYC_19030024_ChIP-ChIP_MESCs_Mouse1.92295233
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91015646
40TTF2_22483619_ChIP-Seq_HELA_Human1.90610704
41REST_21632747_ChIP-Seq_MESCs_Mouse1.89062627
42ELK1_22589737_ChIP-Seq_MCF10A_Human1.84586770
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.82930779
44IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.82502565
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.81985525
46POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.81781274
47TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81781274
48GABP_19822575_ChIP-Seq_HepG2_Human1.80908508
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80865476
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.77756087
51MYC_19079543_ChIP-ChIP_MESCs_Mouse1.75571337
52AR_21572438_ChIP-Seq_LNCaP_Human1.73872549
53IRF1_19129219_ChIP-ChIP_H3396_Human1.62549947
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.61914236
55EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.56228042
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54669101
57SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.54642243
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.53879251
59JARID2_20075857_ChIP-Seq_MESCs_Mouse1.52750932
60VDR_22108803_ChIP-Seq_LS180_Human1.52091411
61STAT3_23295773_ChIP-Seq_U87_Human1.48699633
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.45023410
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44340459
64MYC_18940864_ChIP-ChIP_HL60_Human1.42519632
65EZH2_27294783_Chip-Seq_ESCs_Mouse1.42095873
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40970074
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37944784
68TCF4_23295773_ChIP-Seq_U87_Human1.37539041
69CTCF_18555785_ChIP-Seq_MESCs_Mouse1.36557763
70JARID2_20064375_ChIP-Seq_MESCs_Mouse1.36057527
71SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35052689
72P300_19829295_ChIP-Seq_ESCs_Human1.34021716
73BCAT_22108803_ChIP-Seq_LS180_Human1.33997721
74EED_16625203_ChIP-ChIP_MESCs_Mouse1.32883205
75SMAD4_21799915_ChIP-Seq_A2780_Human1.32754169
76CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.32443653
77ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32249944
78ERA_21632823_ChIP-Seq_H3396_Human1.31562676
79IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30336478
80LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.29393376
81EZH2_27304074_Chip-Seq_ESCs_Mouse1.29388653
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29167732
83CBP_20019798_ChIP-Seq_JUKART_Human1.29167732
84GATA3_21878914_ChIP-Seq_MCF-7_Human1.26583920
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.26189652
86AR_25329375_ChIP-Seq_VCAP_Human1.25834224
87NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24191114
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23641421
89OCT4_20526341_ChIP-Seq_ESCs_Human1.23370753
90IRF8_22096565_ChIP-ChIP_GC-B_Human1.22268637
91PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22268487
92MYC_19829295_ChIP-Seq_ESCs_Human1.20831080
93SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.17899699
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17830279
95REST_18959480_ChIP-ChIP_MESCs_Mouse1.16933885
96ETV2_25802403_ChIP-Seq_MESCs_Mouse1.15801302
97SMAD4_21741376_ChIP-Seq_EPCs_Human1.15620063
98TAF15_26573619_Chip-Seq_HEK293_Human1.15057467
99MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.13011602
100PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12233380
101IRF8_21731497_ChIP-ChIP_J774_Mouse1.11987768
102TP53_22573176_ChIP-Seq_HFKS_Human1.11569273
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11412061
104WDR5_24793694_ChIP-Seq_LNCAP_Human1.11155211
105SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.10755690
106CIITA_25753668_ChIP-Seq_RAJI_Human1.10014184
107BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08478575
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08426779
109RNF2_27304074_Chip-Seq_ESCs_Mouse1.08210021
110BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07940680
111TAF2_19829295_ChIP-Seq_ESCs_Human1.07919882
112SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.07730934
113RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05928147
114RUNX2_22187159_ChIP-Seq_PCA_Human1.05907525
115BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05798557
116NANOG_20526341_ChIP-Seq_ESCs_Human1.05606837
117ARNT_22903824_ChIP-Seq_MCF-7_Human1.05584464
118TDRD3_21172665_ChIP-Seq_MCF-7_Human1.05322519
119FLI1_27457419_Chip-Seq_LIVER_Mouse1.04321838
120SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04312744
121IGF1R_20145208_ChIP-Seq_DFB_Human1.02779483
122EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.02515302
123E2F1_20622854_ChIP-Seq_HELA_Human1.01258146
124YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00463485
125SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99914503
126ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99823960
127RXR_22108803_ChIP-Seq_LS180_Human0.99664408
128P53_21459846_ChIP-Seq_SAOS-2_Human0.99649280
129VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99601660
130SMAD3_21741376_ChIP-Seq_ESCs_Human0.99537513
131TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99423972
132STAT4_19710469_ChIP-ChIP_TH1__Mouse0.99035146
133OCT1_27270436_Chip-Seq_PROSTATE_Human0.98859646
134PIAS1_25552417_ChIP-Seq_VCAP_Human0.98536375
135RAC3_21632823_ChIP-Seq_H3396_Human0.97907329
136TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96957995
137NANOG_19829295_ChIP-Seq_ESCs_Human0.96819143
138SOX2_19829295_ChIP-Seq_ESCs_Human0.96819143
139PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.96416184
140POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96027796
141KDM2B_26808549_Chip-Seq_REH_Human0.95810859
142NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95279857
143SMAD3_21741376_ChIP-Seq_EPCs_Human0.95134585
144TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94471111
145TCF4_22108803_ChIP-Seq_LS180_Human0.94177348
146BCL6_27268052_Chip-Seq_Bcells_Human0.93627266
147ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93401825
148SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93317162
149FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93214782
150FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93166495
151FOXA1_25329375_ChIP-Seq_VCAP_Human0.93166495
152SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.93010983
153RNF2_27304074_Chip-Seq_NSC_Mouse0.92712897
154CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.92047879
155FOXH1_21741376_ChIP-Seq_EPCs_Human0.91910827
156CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.91022255
157FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90891923
158MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90567601
159SPI1_23547873_ChIP-Seq_NB4_Human0.89988468
160CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.88496147
161POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.88176271
162EZH2_22144423_ChIP-Seq_EOC_Human0.87994871
163ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87613125
164SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87287061
165ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.86368082
166PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86150360
167MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.85761781
168PADI4_21655091_ChIP-ChIP_MCF-7_Human0.84742410
169DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81295813
170STAT1_20625510_ChIP-Seq_HELA_Human0.80398260
171SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.79585444
172ER_23166858_ChIP-Seq_MCF-7_Human0.79544748
173NANOG_18555785_ChIP-Seq_MESCs_Mouse0.77371716
174NOTCH1_21737748_ChIP-Seq_TLL_Human0.76927360
175RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.76427815
176MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.76216701
177CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.76095104
178GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.73004785
179LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.72940271
180MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.72484899
181ERG_20517297_ChIP-Seq_VCAP_Human0.70797276
182ELF5_23300383_ChIP-Seq_T47D_Human0.70622443
183YY1_22570637_ChIP-Seq_MALME-3M_Human0.69806814
184CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.69592977
185MYCN_18555785_ChIP-Seq_MESCs_Mouse0.69074811
186FUS_26573619_Chip-Seq_HEK293_Human0.68823533

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001529_abnormal_vocalization3.94195037
2MP0009379_abnormal_foot_pigmentation3.87395034
3MP0003880_abnormal_central_pattern3.46918401
4MP0003646_muscle_fatigue2.92450918
5MP0001905_abnormal_dopamine_level2.92283920
6MP0005377_hearing/vestibular/ear_phenot2.86893770
7MP0003878_abnormal_ear_physiology2.86893770
8MP0000569_abnormal_digit_pigmentation2.75949481
9MP0002736_abnormal_nociception_after2.61781728
10MP0003195_calcinosis2.44832816
11MP0005670_abnormal_white_adipose2.41985280
12MP0002638_abnormal_pupillary_reflex2.30441522
13MP0001968_abnormal_touch/_nociception2.28553319
14MP0001986_abnormal_taste_sensitivity2.23293907
15MP0002163_abnormal_gland_morphology2.19769281
16MP0006276_abnormal_autonomic_nervous2.12707998
17MP0004043_abnormal_pH_regulation2.00719941
18MP0000372_irregular_coat_pigmentation1.96347981
19MP0005423_abnormal_somatic_nervous1.94345158
20MP0006035_abnormal_mitochondrial_morpho1.91829263
21MP0001485_abnormal_pinna_reflex1.90099727
22MP0003186_abnormal_redox_activity1.89604428
23MP0005671_abnormal_response_to1.89052983
24MP0002272_abnormal_nervous_system1.88502231
25MP0004145_abnormal_muscle_electrophysio1.85716026
26MP0006036_abnormal_mitochondrial_physio1.84964512
27MP0002148_abnormal_hypersensitivity_rea1.83016113
28MP0001188_hyperpigmentation1.82894349
29MP0005645_abnormal_hypothalamus_physiol1.82437842
30MP0009745_abnormal_behavioral_response1.80386142
31MP0005379_endocrine/exocrine_gland_phen1.78716168
32MP0004142_abnormal_muscle_tone1.77259788
33MP0003724_increased_susceptibility_to1.73860831
34MP0002876_abnormal_thyroid_physiology1.73309590
35MP0002735_abnormal_chemical_nociception1.73264372
36MP0008789_abnormal_olfactory_epithelium1.71735969
37MP0010386_abnormal_urinary_bladder1.67094572
38MP0002064_seizures1.66226427
39MP0001984_abnormal_olfaction1.66155694
40MP0001835_abnormal_antigen_presentation1.64605473
41MP0006292_abnormal_olfactory_placode1.64461735
42MP0003698_abnormal_male_reproductive1.63663806
43MP0009785_altered_susceptibility_to1.58338389
44MP0005174_abnormal_tail_pigmentation1.53115996
45MP0005075_abnormal_melanosome_morpholog1.52616632
46MP0005083_abnormal_biliary_tract1.52392563
47MP0000015_abnormal_ear_pigmentation1.47889523
48MP0009046_muscle_twitch1.47468404
49MP0002928_abnormal_bile_duct1.46558130
50MP0008961_abnormal_basal_metabolism1.46388755
51MP0005167_abnormal_blood-brain_barrier1.46330690
52MP0005394_taste/olfaction_phenotype1.45906024
53MP0005499_abnormal_olfactory_system1.45906024
54MP0005084_abnormal_gallbladder_morpholo1.45161443
55MP0002572_abnormal_emotion/affect_behav1.44843530
56MP0004885_abnormal_endolymph1.43259343
57MP0005000_abnormal_immune_tolerance1.41644371
58MP0001970_abnormal_pain_threshold1.40291342
59MP0002938_white_spotting1.39318299
60MP0002837_dystrophic_cardiac_calcinosis1.35389645
61MP0008872_abnormal_physiological_respon1.32403260
62MP0003635_abnormal_synaptic_transmissio1.31201151
63MP0004130_abnormal_muscle_cell1.31152930
64MP0001929_abnormal_gametogenesis1.30098236
65MP0002734_abnormal_mechanical_nocicepti1.29242506
66MP0003045_fibrosis1.28512539
67MP0002653_abnormal_ependyma_morphology1.28031841
68MP0009333_abnormal_splenocyte_physiolog1.27767643
69MP0001501_abnormal_sleep_pattern1.25894084
70MP0000685_abnormal_immune_system1.25565193
71MP0003122_maternal_imprinting1.25054753
72MP0001348_abnormal_lacrimal_gland1.24363992
73MP0001963_abnormal_hearing_physiology1.21246382
74MP0005646_abnormal_pituitary_gland1.21108816
75MP0002132_abnormal_respiratory_system1.19486239
76MP0005253_abnormal_eye_physiology1.16519773
77MP0005408_hypopigmentation1.16403646
78MP0001800_abnormal_humoral_immune1.14901724
79MP0004147_increased_porphyrin_level1.14640001
80MP0005409_darkened_coat_color1.14515170
81MP0002063_abnormal_learning/memory/cond1.14411494
82MP0002822_catalepsy1.13847326
83MP0008877_abnormal_DNA_methylation1.12843971
84MP0002723_abnormal_immune_serum1.11445493
85MP0003787_abnormal_imprinting1.11114678
86MP0005025_abnormal_response_to1.11047135
87MP0002420_abnormal_adaptive_immunity1.10783515
88MP0002733_abnormal_thermal_nociception1.10342050
89MP0001440_abnormal_grooming_behavior1.10325435
90MP0003763_abnormal_thymus_physiology1.08225689
91MP0000427_abnormal_hair_cycle1.07032093
92MP0001819_abnormal_immune_cell1.06899024
93MP0004742_abnormal_vestibular_system1.05236519
94MP0000026_abnormal_inner_ear1.05221993
95MP0002398_abnormal_bone_marrow1.04465788
96MP0001765_abnormal_ion_homeostasis1.03186393
97MP0003866_abnormal_defecation1.01190019
98MP0003136_yellow_coat_color1.01099807
99MP0004133_heterotaxia1.00786110
100MP0002229_neurodegeneration0.99452407
101MP0005310_abnormal_salivary_gland0.97670066
102MP0005410_abnormal_fertilization0.95861751
103MP0000230_abnormal_systemic_arterial0.95369397
104MP0003656_abnormal_erythrocyte_physiolo0.95124504
105MP0003879_abnormal_hair_cell0.94081381
106MP0002095_abnormal_skin_pigmentation0.93876689
107MP0000716_abnormal_immune_system0.92645679
108MP0000631_abnormal_neuroendocrine_gland0.92598653
109MP0002452_abnormal_antigen_presenting0.91848048
110MP0002067_abnormal_sensory_capabilities0.91641606
111MP0004859_abnormal_synaptic_plasticity0.91522194
112MP0000470_abnormal_stomach_morphology0.91002165
113MP0001764_abnormal_homeostasis0.90982583
114MP0003436_decreased_susceptibility_to0.88759431
115MP0002138_abnormal_hepatobiliary_system0.88074883
116MP0001790_abnormal_immune_system0.87957321
117MP0005387_immune_system_phenotype0.87957321
118MP0008569_lethality_at_weaning0.87560068
119MP0005448_abnormal_energy_balance0.87406645
120MP0003137_abnormal_impulse_conducting0.85355467
121MP0002102_abnormal_ear_morphology0.85113795
122MP0004924_abnormal_behavior0.84953796
123MP0005386_behavior/neurological_phenoty0.84953796
124MP0001542_abnormal_bone_strength0.84614650
125MP0002429_abnormal_blood_cell0.83614161
126MP0002210_abnormal_sex_determination0.82928651
127MP0001853_heart_inflammation0.82821993
128MP0005636_abnormal_mineral_homeostasis0.82772212
129MP0000955_abnormal_spinal_cord0.81991626
130MP0008995_early_reproductive_senescence0.81744200
131MP0000465_gastrointestinal_hemorrhage0.81152973
132MP0003786_premature_aging0.80917983
133MP0006072_abnormal_retinal_apoptosis0.80877436
134MP0002752_abnormal_somatic_nervous0.80430495
135MP0002405_respiratory_system_inflammati0.80171389
136MP0005551_abnormal_eye_electrophysiolog0.79892906
137MP0001486_abnormal_startle_reflex0.79054226
138MP0002693_abnormal_pancreas_physiology0.78900551
139MP0002419_abnormal_innate_immunity0.78478425
140MP0002184_abnormal_innervation0.76144258
141MP0000689_abnormal_spleen_morphology0.75502227
142MP0002882_abnormal_neuron_morphology0.74965346
143MP0002722_abnormal_immune_system0.73951137
144MP0002751_abnormal_autonomic_nervous0.73641621
145MP0004085_abnormal_heartbeat0.72127189
146MP0004883_abnormal_blood_vessel0.71682612
147MP0002557_abnormal_social/conspecific_i0.71379110
148MP0000920_abnormal_myelination0.71332702
149MP0002168_other_aberrant_phenotype0.70646330
150MP0009764_decreased_sensitivity_to0.70532962
151MP0005195_abnormal_posterior_eye0.70166207
152MP0004270_analgesia0.69809280
153MP0002234_abnormal_pharynx_morphology0.69403593
154MP0008875_abnormal_xenobiotic_pharmacok0.69248247
155MP0003633_abnormal_nervous_system0.68523878
156MP0003693_abnormal_embryo_hatching0.68136519
157MP0005535_abnormal_body_temperature0.68134779
158MP0002161_abnormal_fertility/fecundity0.67921316

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.58070550
2Genetic anticipation (HP:0003743)6.05059757
3Mitochondrial inheritance (HP:0001427)5.89169198
4Abnormal mitochondria in muscle tissue (HP:0008316)5.86488758
5Progressive macrocephaly (HP:0004481)5.38221496
6Hepatocellular necrosis (HP:0001404)5.21265163
7Acute encephalopathy (HP:0006846)5.14719668
8Progressive cerebellar ataxia (HP:0002073)5.00697118
9Increased CSF lactate (HP:0002490)4.98882432
10Abnormality of cells of the erythroid lineage (HP:0012130)4.88352422
11Increased hepatocellular lipid droplets (HP:0006565)4.45213753
12Hepatic necrosis (HP:0002605)4.34456697
13Abnormal number of erythroid precursors (HP:0012131)4.33430316
14Congenital stationary night blindness (HP:0007642)4.18421970
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.17142290
16Renal Fanconi syndrome (HP:0001994)4.13299945
17Attenuation of retinal blood vessels (HP:0007843)4.03130132
18Abnormality of glycolysis (HP:0004366)3.87126559
19Increased serum pyruvate (HP:0003542)3.87126559
20Lipid accumulation in hepatocytes (HP:0006561)3.84408467
21Gaze-evoked nystagmus (HP:0000640)3.82328382
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.76995781
23Reticulocytopenia (HP:0001896)3.71500135
243-Methylglutaconic aciduria (HP:0003535)3.67231232
25Nephronophthisis (HP:0000090)3.65824009
26Decreased activity of mitochondrial respiratory chain (HP:0008972)3.60636517
27Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.60636517
28Exertional dyspnea (HP:0002875)3.55524122
29Optic disc pallor (HP:0000543)3.53032514
30Exercise intolerance (HP:0003546)3.51328998
31Respiratory failure (HP:0002878)3.43107877
32Abnormality of midbrain morphology (HP:0002418)3.38346853
33Molar tooth sign on MRI (HP:0002419)3.38346853
34Chronic hepatic failure (HP:0100626)3.36360056
35Bony spicule pigmentary retinopathy (HP:0007737)3.27165835
36Diplopia (HP:0000651)3.27131925
37Abnormality of binocular vision (HP:0011514)3.27131925
38Hypothermia (HP:0002045)3.25167408
39Decreased circulating renin level (HP:0003351)3.21953351
40Abnormality of the renal medulla (HP:0100957)3.21045497
41Lactic acidosis (HP:0003128)3.15447186
42Increased serum lactate (HP:0002151)3.14001734
43Increased intramyocellular lipid droplets (HP:0012240)3.13304514
44Decreased central vision (HP:0007663)3.12830250
45Abnormal drinking behavior (HP:0030082)3.11755619
46Polydipsia (HP:0001959)3.11755619
47Cerebral edema (HP:0002181)3.09159129
48Retinal dysplasia (HP:0007973)3.08042389
49Leukodystrophy (HP:0002415)3.08023610
50Absent/shortened dynein arms (HP:0200106)3.02640477
51Dynein arm defect of respiratory motile cilia (HP:0012255)3.02640477
52Respiratory difficulties (HP:0002880)3.02222364
53Macrocytic anemia (HP:0001972)2.96609955
54Medial flaring of the eyebrow (HP:0010747)2.91320960
55Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.85477829
56Protruding tongue (HP:0010808)2.82751100
57Cystic liver disease (HP:0006706)2.82738665
58Sclerocornea (HP:0000647)2.79007967
59Abolished electroretinogram (ERG) (HP:0000550)2.78794341
60Pallor (HP:0000980)2.78536629
61Parakeratosis (HP:0001036)2.78038729
62Clumsiness (HP:0002312)2.77770104
63Hyperkalemia (HP:0002153)2.75989396
64Type I transferrin isoform profile (HP:0003642)2.74742975
65Abnormality of the renal cortex (HP:0011035)2.73742163
66Nephrogenic diabetes insipidus (HP:0009806)2.72318996
67Abnormality of the heme biosynthetic pathway (HP:0010472)2.68622329
68Decreased electroretinogram (ERG) amplitude (HP:0000654)2.66896326
69Abnormality of renal resorption (HP:0011038)2.66711860
70Abnormal hair whorl (HP:0010721)2.66349053
71Type II lissencephaly (HP:0007260)2.66295480
72Gait imbalance (HP:0002141)2.65001518
73Congenital primary aphakia (HP:0007707)2.64279007
74Hypoplastic ischia (HP:0003175)2.63880167
75Tubular atrophy (HP:0000092)2.58060234
76Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.57904559
77Congenital sensorineural hearing impairment (HP:0008527)2.57141282
78Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.54117066
79Increased muscle lipid content (HP:0009058)2.52777918
80Myokymia (HP:0002411)2.50012436
81Polyuria (HP:0000103)2.43359874
82Febrile seizures (HP:0002373)2.40729122
83Abnormal ciliary motility (HP:0012262)2.37148412
84Large for gestational age (HP:0001520)2.36908078
85Increased neuronal autofluorescent lipopigment (HP:0002074)2.36330184
86Inability to walk (HP:0002540)2.34441888
87Focal motor seizures (HP:0011153)2.31844543
88True hermaphroditism (HP:0010459)2.31517247
89Impaired smooth pursuit (HP:0007772)2.30697116
90Aplastic anemia (HP:0001915)2.29418876
91Broad-based gait (HP:0002136)2.28028464
92Abnormality of macular pigmentation (HP:0008002)2.24746791
93Postural instability (HP:0002172)2.23989293
94Elevated erythrocyte sedimentation rate (HP:0003565)2.21110081
95Emotional lability (HP:0000712)2.20361367
96Congenital hepatic fibrosis (HP:0002612)2.19931942
97X-linked dominant inheritance (HP:0001423)2.19378886
98Limb dystonia (HP:0002451)2.18865715
99Abnormality of the ischium (HP:0003174)2.13276567
100Abnormal urine output (HP:0012590)2.10221949
101Abnormal protein glycosylation (HP:0012346)2.09653606
102Abnormal glycosylation (HP:0012345)2.09653606
103Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.09653606
104Abnormal protein N-linked glycosylation (HP:0012347)2.09653606
105Pendular nystagmus (HP:0012043)2.09459982
106Absent speech (HP:0001344)2.07241133
107Abnormality of alanine metabolism (HP:0010916)2.05872334
108Hyperalaninemia (HP:0003348)2.05872334
109Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.05872334
110CNS demyelination (HP:0007305)2.04429808
111Neuroendocrine neoplasm (HP:0100634)2.03661834
112Cerebellar dysplasia (HP:0007033)2.03533223
113Abnormality of potassium homeostasis (HP:0011042)2.01906637
114Pancreatic fibrosis (HP:0100732)2.01159253
115Reduced antithrombin III activity (HP:0001976)2.00397146
116Poor suck (HP:0002033)2.00366486
117Patellar aplasia (HP:0006443)1.99205001
118Anencephaly (HP:0002323)1.99197610
119Hypoplasia of the pons (HP:0012110)1.97741766
120Urinary bladder sphincter dysfunction (HP:0002839)1.97592380
121Abnormal respiratory motile cilium physiology (HP:0012261)1.97293159
122Keratoconus (HP:0000563)1.96933002
123Increased corneal curvature (HP:0100692)1.96933002
124Abnormality of renin-angiotensin system (HP:0000847)1.96583762
125Bulbous nose (HP:0000414)1.92059574
126Amniotic constriction ring (HP:0009775)1.91858171
127Abnormality of placental membranes (HP:0011409)1.91858171
128Abnormality of the renal collecting system (HP:0004742)1.90535394
129Aplasia/Hypoplasia of the tongue (HP:0010295)1.90140672
130Widely spaced teeth (HP:0000687)1.89613367
131Dysmetric saccades (HP:0000641)1.89528955
132Severe visual impairment (HP:0001141)1.89414447
133Aplasia/Hypoplasia of the patella (HP:0006498)1.88966110
134Palpebral edema (HP:0100540)1.88223594
135Abnormality of the pons (HP:0007361)1.86466921
136Macular degeneration (HP:0000608)1.86056564
137Focal seizures (HP:0007359)1.85946889
138Congenital ichthyosiform erythroderma (HP:0007431)1.85894619
139Tubulointerstitial nephritis (HP:0001970)1.84178216
140Cerebral hypomyelination (HP:0006808)1.83691511
141Vaginal atresia (HP:0000148)1.83401757
142Lissencephaly (HP:0001339)1.82023381
143Aplasia/Hypoplasia of the sacrum (HP:0008517)1.81847652
144IgM deficiency (HP:0002850)1.81357346
145Chorioretinal atrophy (HP:0000533)1.81213564
146Renal tubular dysfunction (HP:0000124)1.81197654
147Dialeptic seizures (HP:0011146)1.79606146
148Abnormality of renal excretion (HP:0011036)1.79354300
149Ectopic kidney (HP:0000086)1.77889260
150Thrombocytosis (HP:0001894)1.77797255
151Abnormality of the pubic bones (HP:0003172)1.76922036
152Male pseudohermaphroditism (HP:0000037)1.76743243
153Genital tract atresia (HP:0001827)1.76536241
154Aplasia/Hypoplasia of the tibia (HP:0005772)1.76523971
155Hemiparesis (HP:0001269)1.76513236
156Absent rod-and cone-mediated responses on ERG (HP:0007688)1.76051677
157Amelogenesis imperfecta (HP:0000705)1.76042011
158Furrowed tongue (HP:0000221)1.75497768
159Progressive inability to walk (HP:0002505)1.73631297
160Pheochromocytoma (HP:0002666)1.72289315
161Absence seizures (HP:0002121)1.70566889
162Poor coordination (HP:0002370)1.69451778
163Hyperventilation (HP:0002883)1.68259568
164Abnormality of ocular smooth pursuit (HP:0000617)1.68134242
165Pancreatic cysts (HP:0001737)1.67968959
166Petechiae (HP:0000967)1.67674826
167Prolonged QT interval (HP:0001657)1.67560640
168Neutropenia (HP:0001875)1.67430525
169IgG deficiency (HP:0004315)1.66783041
170Hyperphosphaturia (HP:0003109)1.65767655
171Delusions (HP:0000746)1.63323539
172Microvesicular hepatic steatosis (HP:0001414)1.62699723
173Aplasia/Hypoplasia of the lens (HP:0008063)1.61848909
174Methylmalonic aciduria (HP:0012120)1.61481270
175Irregular epiphyses (HP:0010582)1.58648534
176Abnormal respiratory epithelium morphology (HP:0012253)1.57918732
177Abnormal respiratory motile cilium morphology (HP:0005938)1.57918732
178Glycosuria (HP:0003076)1.56966424
179Abnormality of urine glucose concentration (HP:0011016)1.56966424
18011 pairs of ribs (HP:0000878)1.55737645
181Abnormal rod and cone electroretinograms (HP:0008323)1.55284565
182Polyphagia (HP:0002591)1.54800320
183Redundant skin (HP:0001582)1.54759467
184Birth length less than 3rd percentile (HP:0003561)1.54177213
185Chronic sinusitis (HP:0011109)1.53940053
186Epileptic encephalopathy (HP:0200134)1.53799506
187Atonic seizures (HP:0010819)1.53750435
188Blindness (HP:0000618)1.53081944

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.58584080
2MAP3K124.50793106
3INSRR3.61142200
4STK163.55388336
5SIK23.15587739
6NME22.80234139
7NME12.78794693
8MST42.59975540
9CASK2.51579047
10ACVR1B2.48830658
11PIM22.43949519
12VRK12.29659026
13MAP4K22.22913894
14TESK22.21223285
15BUB12.15073561
16CDK192.09857013
17MAP2K72.00265030
18DAPK21.99391663
19WNK41.96035079
20RIPK41.93740978
21SIK31.91417197
22ARAF1.88083893
23MAPKAPK51.86235081
24MYLK1.75726040
25CAMK1D1.73896119
26LIMK11.73453739
27GRK11.67922784
28BMPR21.66338907
29CAMK1G1.61790291
30EIF2AK31.60014471
31TAOK31.58997224
32EIF2AK11.53596522
33MAPK151.50776464
34PLK21.49382999
35ZAK1.49151566
36PINK11.47164085
37TSSK61.35878914
38STK381.33781995
39GRK51.33643051
40WNK31.31761273
41ADRBK21.30349983
42TNK21.30187572
43CAMKK21.25171326
44CDK81.24428750
45BCR1.23719888
46ERBB31.23555465
47BLK1.22506658
48TESK11.21272982
49NUAK11.18657422
50TEC1.18358542
51PTK2B1.17538909
52BRAF1.16798268
53ILK1.15392095
54AKT31.14822419
55SYK1.12988615
56CCNB11.12357394
57MAPK131.12024202
58TNIK1.09987688
59TXK1.09922388
60BMPR1B1.08422136
61CAMK11.06261668
62CAMKK11.05331409
63KIT1.02438345
64DYRK21.02101640
65MAP2K61.01420009
66GRK60.97834447
67DDR20.95492758
68DAPK10.93672713
69PRKD30.90960877
70TIE10.87854310
71MARK30.87780581
72BCKDK0.86297274
73PRKCE0.85029383
74CSNK1G30.84812855
75PBK0.84795486
76YES10.84285997
77PHKG20.83354111
78PHKG10.83354111
79SRPK10.82593947
80WNK10.82310853
81MAP3K70.81178770
82PRKCG0.81133423
83PASK0.80704640
84ABL20.75812489
85GRK70.74986101
86NEK20.73346838
87STK110.72303425
88PRKAA20.71992513
89PNCK0.71489338
90MAP3K40.71177618
91OXSR10.71089672
92IRAK10.70585674
93PRKCH0.69564343
94PRKAA10.67978511
95CAMK2B0.67876620
96CAMK40.67326248
97KDR0.67062103
98UHMK10.66834955
99MUSK0.65022118
100STK390.64698060
101ADRBK10.64269414
102MARK20.62568872
103RAF10.62543430
104PAK10.61843779
105CHUK0.61333687
106PAK30.61229283
107PLK30.60994204
108TYRO30.59953375
109NTRK30.59701428
110MKNK10.58925131
111BRSK10.58666679
112RPS6KA60.58513851
113CDK180.56733606
114WEE10.56517802
115PLK40.55719065
116OBSCN0.55621782
117TLK10.55216178
118PRKD20.54803120
119ZAP700.54544691
120PIK3CA0.54168571
121PDK10.53321996
122TYK20.53138148
123BTK0.51990347
124CDK11A0.51711020
125LYN0.51686082
126IRAK40.51640671
127MAPK40.51495387
128EPHA40.51165279
129CAMK2A0.50202807
130TGFBR10.50030289
131ITK0.49635720
132PRPF4B0.49478017
133DAPK30.48982277
134CSNK2A10.48489357
135MAP4K10.48210800
136ROCK20.47757000
137PIK3CG0.47670676
138CDK150.47622228
139TAOK10.47528508
140BRSK20.46779458
141LRRK20.46750981
142FES0.46737803
143PRKCZ0.46724472
144MAPKAPK30.46390844
145IKBKB0.45753011
146MINK10.45295239
147CDK140.44992467
148STK38L0.44054171
149MAP3K140.43946196
150SGK20.43847209
151PRKCQ0.43442254
152LCK0.43177142
153PRKG10.42836341
154MARK10.42484550
155SGK2230.40212958
156SGK4940.40212958
157RPS6KA50.40209389
158MAP3K110.39907823
159CSNK2A20.39871207
160SGK10.39182405
161PKN10.38160945
162AURKA0.38108490
163TRPM70.38046967
164NTRK20.37970622
165PRKCA0.37850598
166DYRK30.37840824
167PRKACA0.37659892
168PDPK10.36312858
169MKNK20.35723792
170MAP2K40.35646544
171MAPK110.34841484

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.44438481
2Ribosome_Homo sapiens_hsa030105.30046962
3Parkinsons disease_Homo sapiens_hsa050124.67988436
4Proteasome_Homo sapiens_hsa030504.52896373
5Alzheimers disease_Homo sapiens_hsa050103.43966434
6Huntingtons disease_Homo sapiens_hsa050163.30863295
7RNA polymerase_Homo sapiens_hsa030203.21733606
8Protein export_Homo sapiens_hsa030603.12807183
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.80943076
10Butanoate metabolism_Homo sapiens_hsa006502.17876908
11Collecting duct acid secretion_Homo sapiens_hsa049662.15498765
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.93727288
13Pyrimidine metabolism_Homo sapiens_hsa002401.91513588
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.86378808
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.86317053
16Nitrogen metabolism_Homo sapiens_hsa009101.85608342
17SNARE interactions in vesicular transport_Homo sapiens_hsa041301.81090183
18ABC transporters_Homo sapiens_hsa020101.79254452
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.66991551
20Cardiac muscle contraction_Homo sapiens_hsa042601.66073291
21Calcium signaling pathway_Homo sapiens_hsa040201.56797928
22Insulin secretion_Homo sapiens_hsa049111.56653629
23Tryptophan metabolism_Homo sapiens_hsa003801.55075220
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.51922743
25DNA replication_Homo sapiens_hsa030301.51043729
26Selenocompound metabolism_Homo sapiens_hsa004501.47528770
27Vibrio cholerae infection_Homo sapiens_hsa051101.44845740
28Spliceosome_Homo sapiens_hsa030401.35284700
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.33418314
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.29204861
31Fatty acid biosynthesis_Homo sapiens_hsa000611.27907271
32Rheumatoid arthritis_Homo sapiens_hsa053231.24075699
33Purine metabolism_Homo sapiens_hsa002301.23558888
34Vascular smooth muscle contraction_Homo sapiens_hsa042701.22721800
35Nucleotide excision repair_Homo sapiens_hsa034201.22653395
36Gastric acid secretion_Homo sapiens_hsa049711.20982864
37Mismatch repair_Homo sapiens_hsa034301.20936295
38Oxytocin signaling pathway_Homo sapiens_hsa049211.20727727
39Synaptic vesicle cycle_Homo sapiens_hsa047211.18346384
40Basal transcription factors_Homo sapiens_hsa030221.17568333
41Nicotine addiction_Homo sapiens_hsa050331.14248767
42Salivary secretion_Homo sapiens_hsa049701.11041641
43Homologous recombination_Homo sapiens_hsa034401.08474130
44Type II diabetes mellitus_Homo sapiens_hsa049301.05949348
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.05926210
46Lysine degradation_Homo sapiens_hsa003101.05392623
47Base excision repair_Homo sapiens_hsa034101.05112330
48Aldosterone synthesis and secretion_Homo sapiens_hsa049251.03585903
49Allograft rejection_Homo sapiens_hsa053301.03507940
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.03203676
51RNA degradation_Homo sapiens_hsa030180.97727501
52Dorso-ventral axis formation_Homo sapiens_hsa043200.97174999
53Glycerophospholipid metabolism_Homo sapiens_hsa005640.96205631
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95766787
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.94131354
56Primary immunodeficiency_Homo sapiens_hsa053400.93213711
57Type I diabetes mellitus_Homo sapiens_hsa049400.92722168
58cAMP signaling pathway_Homo sapiens_hsa040240.92537693
59Phototransduction_Homo sapiens_hsa047440.90994854
60Glycerolipid metabolism_Homo sapiens_hsa005610.89477119
61Pyruvate metabolism_Homo sapiens_hsa006200.85387988
62Ovarian steroidogenesis_Homo sapiens_hsa049130.83437120
63Graft-versus-host disease_Homo sapiens_hsa053320.82304993
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82022999
65Sulfur metabolism_Homo sapiens_hsa009200.81706547
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78876247
67Phagosome_Homo sapiens_hsa041450.77707678
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76686135
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.76643775
70Fatty acid elongation_Homo sapiens_hsa000620.75652105
71Sulfur relay system_Homo sapiens_hsa041220.75460578
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.74619415
73Non-homologous end-joining_Homo sapiens_hsa034500.72463560
74Chemical carcinogenesis_Homo sapiens_hsa052040.71300650
75Epstein-Barr virus infection_Homo sapiens_hsa051690.69244373
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69238436
77Serotonergic synapse_Homo sapiens_hsa047260.68353635
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66944998
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66700404
80Retinol metabolism_Homo sapiens_hsa008300.65562903
81Taste transduction_Homo sapiens_hsa047420.65431719
82Caffeine metabolism_Homo sapiens_hsa002320.64843752
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64019241
84Metabolic pathways_Homo sapiens_hsa011000.63366077
85Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62169783
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61291135
87Long-term depression_Homo sapiens_hsa047300.58809609
88Renin secretion_Homo sapiens_hsa049240.56012935
89Autoimmune thyroid disease_Homo sapiens_hsa053200.55013584
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54596251
91Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53828346
92MAPK signaling pathway_Homo sapiens_hsa040100.53366522
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52984047
94RNA transport_Homo sapiens_hsa030130.48052603
95Peroxisome_Homo sapiens_hsa041460.47708230
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47609162
97Arachidonic acid metabolism_Homo sapiens_hsa005900.44602286
98African trypanosomiasis_Homo sapiens_hsa051430.44132976
99Morphine addiction_Homo sapiens_hsa050320.43408483
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43131477
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42642230
102Steroid biosynthesis_Homo sapiens_hsa001000.42147743
103GABAergic synapse_Homo sapiens_hsa047270.41453673
104Tyrosine metabolism_Homo sapiens_hsa003500.41427829
105Hematopoietic cell lineage_Homo sapiens_hsa046400.40794612
106Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40774553
107Glutathione metabolism_Homo sapiens_hsa004800.40521707
108beta-Alanine metabolism_Homo sapiens_hsa004100.39945432
109Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.39173645
110Amphetamine addiction_Homo sapiens_hsa050310.38454251
111Circadian rhythm_Homo sapiens_hsa047100.36932490
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.36278822
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36177653
114Folate biosynthesis_Homo sapiens_hsa007900.36059040
115Olfactory transduction_Homo sapiens_hsa047400.35430061
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35403487
117Mineral absorption_Homo sapiens_hsa049780.35241332
118Platelet activation_Homo sapiens_hsa046110.34380219
119Vitamin B6 metabolism_Homo sapiens_hsa007500.34188532
120Asthma_Homo sapiens_hsa053100.33958659
121Histidine metabolism_Homo sapiens_hsa003400.33894021
122Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33502023
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33318036
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.32536312
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32529495
126Pancreatic secretion_Homo sapiens_hsa049720.32370313
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32113682
128Cysteine and methionine metabolism_Homo sapiens_hsa002700.31854539
129Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.30961218
130Alcoholism_Homo sapiens_hsa050340.30829814
131Dopaminergic synapse_Homo sapiens_hsa047280.30779489
132Pentose phosphate pathway_Homo sapiens_hsa000300.30422931
133Regulation of autophagy_Homo sapiens_hsa041400.30014336
134Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.26622948
135Legionellosis_Homo sapiens_hsa051340.25829038
136Phenylalanine metabolism_Homo sapiens_hsa003600.25015010
137RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23363827
138Circadian entrainment_Homo sapiens_hsa047130.23032265
139Galactose metabolism_Homo sapiens_hsa000520.22697526
140Ether lipid metabolism_Homo sapiens_hsa005650.21471669
141Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.20263338
142Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19580065
143Glutamatergic synapse_Homo sapiens_hsa047240.19052006
144Measles_Homo sapiens_hsa051620.17362780
145Linoleic acid metabolism_Homo sapiens_hsa005910.16835836
146Fanconi anemia pathway_Homo sapiens_hsa034600.16539612
147Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.16317339
148Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.15590362
149N-Glycan biosynthesis_Homo sapiens_hsa005100.15247511
150Cholinergic synapse_Homo sapiens_hsa047250.15119871
151Antigen processing and presentation_Homo sapiens_hsa046120.14340991
152Leishmaniasis_Homo sapiens_hsa051400.13279699
153Cocaine addiction_Homo sapiens_hsa050300.12580555

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