BORCS8-MEF2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene represents numerous read-through transcripts that span GeneID:729991 and 100271849. Many read-through transcripts are predicted to be nonsense-mediated decay (NMD) candidates, and are thought to be non-coding. Some transcripts are predicted to be capable of translation reinitiation at a downstream AUG, resulting in expression of at least one isoform of myocyte enhancer factor 2B (MEF2B) from this read-through locus. At least one additional MEF2B variant and isoform can be expressed from a downstream promoter, and is annotated on GeneID:100271849. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.02576991
2negative regulation of cell killing (GO:0031342)5.02576991
3positive regulation of gamma-delta T cell activation (GO:0046645)4.81639523
4regulation of B cell receptor signaling pathway (GO:0050855)4.58293240
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.45404067
6antigen processing and presentation of endogenous antigen (GO:0019883)4.44548070
7negative regulation of phagocytosis (GO:0050765)4.35442283
8neutrophil activation involved in immune response (GO:0002283)4.28323609
9regulation of interferon-beta biosynthetic process (GO:0045357)4.27998583
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.22030760
11modulation by symbiont of host immune response (GO:0052553)4.11524994
12positive regulation by symbiont of host defense response (GO:0052509)4.11524994
13modulation by symbiont of host defense response (GO:0052031)4.11524994
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.11524994
15modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.11524994
16positive regulation by organism of defense response of other organism involved in symbiotic interact4.11524994
17B cell receptor signaling pathway (GO:0050853)4.04840709
18antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.99864063
19response to peptidoglycan (GO:0032494)3.80815646
20leukocyte aggregation (GO:0070486)3.80677905
21germinal center formation (GO:0002467)3.68677158
22positive thymic T cell selection (GO:0045059)3.67049233
23positive regulation of B cell differentiation (GO:0045579)3.62643270
24regulation of gamma-delta T cell activation (GO:0046643)3.60655257
25immunoglobulin mediated immune response (GO:0016064)3.57802013
26detection of bacterium (GO:0016045)3.40078437
27regulation of B cell differentiation (GO:0045577)3.39079795
28macrophage activation involved in immune response (GO:0002281)3.38862978
29detection of other organism (GO:0098543)3.38497433
30regulation of gamma-delta T cell differentiation (GO:0045586)3.36507947
31regulation of mast cell degranulation (GO:0043304)3.35697953
32response to muramyl dipeptide (GO:0032495)3.32642352
33negative regulation of erythrocyte differentiation (GO:0045647)3.29529093
34respiratory burst (GO:0045730)3.28422136
35cellular extravasation (GO:0045123)3.27605236
36defense response to protozoan (GO:0042832)3.26580891
37NIK/NF-kappaB signaling (GO:0038061)3.22766700
38positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.16438260
39positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.13344024
40B cell homeostasis (GO:0001782)3.12940846
41response to interleukin-15 (GO:0070672)3.11564861
42negative thymic T cell selection (GO:0045060)3.10286658
43cellular response to type I interferon (GO:0071357)3.08176557
44type I interferon signaling pathway (GO:0060337)3.08176557
45negative regulation of leukocyte mediated immunity (GO:0002704)3.06515987
46negative regulation of lymphocyte mediated immunity (GO:0002707)3.05678467
47response to type I interferon (GO:0034340)3.05498582
48thymic T cell selection (GO:0045061)3.04746576
49negative regulation of interleukin-12 production (GO:0032695)3.01218426
50regulation of mast cell activation involved in immune response (GO:0033006)2.98920166
51response to protozoan (GO:0001562)2.98115616
52positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.96462839
53myeloid dendritic cell activation (GO:0001773)2.96285387
54myeloid dendritic cell differentiation (GO:0043011)2.96239138
55response to host immune response (GO:0052572)2.95768530
56response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.95768530
57cellular response to interleukin-15 (GO:0071350)2.95648440
58positive regulation of interferon-alpha production (GO:0032727)2.94872338
59regulation of leukocyte degranulation (GO:0043300)2.93527564
60negative T cell selection (GO:0043383)2.93221776
61granulocyte activation (GO:0036230)2.92319329
62tolerance induction (GO:0002507)2.92098306
63myeloid cell activation involved in immune response (GO:0002275)2.91206008
64neutrophil activation (GO:0042119)2.90751701
65antigen processing and presentation via MHC class Ib (GO:0002475)2.90459682
66B cell mediated immunity (GO:0019724)2.90103889
67regulation of myeloid leukocyte mediated immunity (GO:0002886)2.85641903
68positive T cell selection (GO:0043368)2.82929139
69T cell selection (GO:0045058)2.82693863
70Peyers patch development (GO:0048541)2.81961904
71mucosal-associated lymphoid tissue development (GO:0048537)2.81961904
72response to host (GO:0075136)2.81895148
73response to host defenses (GO:0052200)2.81895148
74response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.81895148
75positive regulation of isotype switching (GO:0045830)2.81879169
76natural killer cell differentiation (GO:0001779)2.77142209
77detection of external biotic stimulus (GO:0098581)2.76736654
78negative regulation of innate immune response (GO:0045824)2.76689684
79regulation of interferon-alpha production (GO:0032647)2.72549619
80negative regulation of T cell mediated immunity (GO:0002710)2.72213578
81regulation of type I interferon-mediated signaling pathway (GO:0060338)2.70733646
82regulation of superoxide anion generation (GO:0032928)2.69295971
83negative regulation of interleukin-6 production (GO:0032715)2.69220122
84lipopolysaccharide-mediated signaling pathway (GO:0031663)2.67717576
85negative regulation of cytokine production involved in immune response (GO:0002719)2.66819715
86regulation of B cell apoptotic process (GO:0002902)2.62732851
87positive regulation of T cell mediated cytotoxicity (GO:0001916)2.61185911
88regulation of T-helper 2 cell differentiation (GO:0045628)2.59941504
89lymphocyte homeostasis (GO:0002260)2.59409499
90positive regulation of B cell activation (GO:0050871)2.59157558
91T cell migration (GO:0072678)2.58971747
92modulation by virus of host process (GO:0019054)2.58942308
93negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.58552061
94leukocyte degranulation (GO:0043299)2.57892684
95mannose metabolic process (GO:0006013)2.57605487
96negative regulation of alpha-beta T cell activation (GO:0046636)2.57553849
97regulation of T cell mediated cytotoxicity (GO:0001914)2.55700064
98modulation by symbiont of host cellular process (GO:0044068)2.55636969
99interferon-gamma-mediated signaling pathway (GO:0060333)2.54405139
100regulation of mast cell activation (GO:0033003)2.53943567

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human3.63654447
2VDR_21846776_ChIP-Seq_THP-1_Human3.02442415
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.01503756
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.48423773
5SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.43237766
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.36793174
7NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.34814754
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.28837908
9E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.19841780
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.19005532
11MAF_26560356_Chip-Seq_TH1_Human2.18483586
12TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.14653827
13VDR_24763502_ChIP-Seq_THP-1_Human2.14437702
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.07009886
15ELK3_25401928_ChIP-Seq_HUVEC_Human2.03315381
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.01608385
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.00901685
18SPI1_23547873_ChIP-Seq_NB4_Human1.98324648
19EGR1_19374776_ChIP-ChIP_THP-1_Human1.97598864
20UTX_26944678_Chip-Seq_JUKART_Human1.97079414
21LXR_22292898_ChIP-Seq_THP-1_Human1.96385429
22KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.88951821
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.87486190
24RUNX1_22412390_ChIP-Seq_EML_Mouse1.85900354
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84246970
26STAT4_19710469_ChIP-ChIP_TH1__Mouse1.83619251
27E2F7_22180533_ChIP-Seq_HELA_Human1.83008638
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.82063491
29KDM2B_26808549_Chip-Seq_SUP-B15_Human1.81549725
30TCF7_22412390_ChIP-Seq_EML_Mouse1.79987142
31MAF_26560356_Chip-Seq_TH2_Human1.76523003
32FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.74758364
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.74403432
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.71892530
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.71363977
36KDM2B_26808549_Chip-Seq_DND41_Human1.68842361
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.68445683
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.67822447
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.64227617
40MYB_26560356_Chip-Seq_TH2_Human1.61296642
41SCL_19346495_ChIP-Seq_HPC-7_Human1.60704835
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59518302
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.57838228
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.57329628
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.55264880
46MYB_26560356_Chip-Seq_TH1_Human1.53770112
47IRF8_27001747_Chip-Seq_BMDM_Mouse1.53274912
48SPI1_23127762_ChIP-Seq_K562_Human1.51645028
49KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.51559993
50SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48328344
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47079622
52RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.40613306
53ELF1_20517297_ChIP-Seq_JURKAT_Human1.37786893
54GATA1_22383799_ChIP-Seq_G1ME_Mouse1.37769431
55CIITA_25753668_ChIP-Seq_RAJI_Human1.33400883
56PU.1_20513432_ChIP-Seq_Bcells_Mouse1.33270918
57TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32837789
58PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30946333
59BCL6_27268052_Chip-Seq_Bcells_Human1.30096731
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.29125680
61RACK7_27058665_Chip-Seq_MCF-7_Human1.28059982
62DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26019901
63GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26016761
64BCOR_27268052_Chip-Seq_Bcells_Human1.25106289
65STAT6_21828071_ChIP-Seq_BEAS2B_Human1.24590192
66TFEB_21752829_ChIP-Seq_HELA_Human1.23736836
67NCOR1_26117541_ChIP-Seq_K562_Human1.22774644
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22373941
69CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22181378
70RUNX_20019798_ChIP-Seq_JUKART_Human1.21603456
71FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.21594250
72MYC_18358816_ChIP-ChIP_MESCs_Mouse1.20214261
73JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.20130429
74PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.18658977
75PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18602755
76P68_20966046_ChIP-Seq_HELA_Human1.18563057
77CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18394554
78RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18096140
79LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15390065
80TET1_21451524_ChIP-Seq_MESCs_Mouse1.15219061
81CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15058321
82SA1_27219007_Chip-Seq_ERYTHROID_Human1.14032452
83CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11551939
84GATA1_19941827_ChIP-Seq_MEL_Mouse1.10289247
85STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.10063065
86CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.06617620
87SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06145403
88VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05884699
89ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03996130
90TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03965935
91SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03258750
92CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03007284
93MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.02429103
94KDM2B_26808549_Chip-Seq_JURKAT_Human1.01609081
95STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01142813
96BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01128153
97HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00578895
98CTCF_26484167_Chip-Seq_Bcells_Mouse1.00534020
99DCP1A_22483619_ChIP-Seq_HELA_Human0.99955482
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99604088

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.09929103
2MP0001835_abnormal_antigen_presentation3.76625060
3MP0003303_peritoneal_inflammation3.43186345
4MP0003763_abnormal_thymus_physiology3.06932766
5MP0000685_abnormal_immune_system3.05389283
6MP0005387_immune_system_phenotype3.01624466
7MP0001790_abnormal_immune_system3.01624466
8MP0005000_abnormal_immune_tolerance2.95708005
9MP0001800_abnormal_humoral_immune2.88343453
10MP0005671_abnormal_response_to2.72676795
11MP0002419_abnormal_innate_immunity2.52004043
12MP0002420_abnormal_adaptive_immunity2.50125262
13MP0002723_abnormal_immune_serum2.50104193
14MP0005025_abnormal_response_to2.48275469
15MP0002452_abnormal_antigen_presenting2.47629195
16MP0001819_abnormal_immune_cell2.45215276
17MP0003724_increased_susceptibility_to2.42686045
18MP0009785_altered_susceptibility_to2.37411508
19MP0005451_abnormal_body_composition2.28469044
20MP0009333_abnormal_splenocyte_physiolog2.24243206
21MP0002398_abnormal_bone_marrow2.22949543
22MP0003172_abnormal_lysosome_physiology2.21314055
23MP0002148_abnormal_hypersensitivity_rea2.17244302
24MP0002405_respiratory_system_inflammati2.13070779
25MP0003300_gastrointestinal_ulcer2.08258664
26MP0005464_abnormal_platelet_physiology2.01610616
27MP0000716_abnormal_immune_system1.98246489
28MP0002396_abnormal_hematopoietic_system1.92267568
29MP0008260_abnormal_autophagy1.91703584
30MP0005058_abnormal_lysosome_morphology1.89719633
31MP0000689_abnormal_spleen_morphology1.89493567
32MP0002722_abnormal_immune_system1.87327448
33MP0009278_abnormal_bone_marrow1.82802646
34MP0004947_skin_inflammation1.81676821
35MP0001533_abnormal_skeleton_physiology1.77136531
36MP0010155_abnormal_intestine_physiology1.76504017
37MP0002429_abnormal_blood_cell1.74236712
38MP0000703_abnormal_thymus_morphology1.72461130
39MP0003191_abnormal_cellular_cholesterol1.63038076
40MP0006082_CNS_inflammation1.61641821
41MP0001845_abnormal_inflammatory_respons1.59936360
42MP0001873_stomach_inflammation1.59931510
43MP0001853_heart_inflammation1.55468389
44MP0000858_altered_metastatic_potential1.42083697
45MP0002166_altered_tumor_susceptibility1.40909363
46MP0003806_abnormal_nucleotide_metabolis1.36467125
47MP0002132_abnormal_respiratory_system1.31590595
48MP0008469_abnormal_protein_level1.31195637
49MP0000490_abnormal_crypts_of1.29609385
50MP0005397_hematopoietic_system_phenotyp1.23539926
51MP0001545_abnormal_hematopoietic_system1.23539926
52MP0005310_abnormal_salivary_gland1.22439260
53MP0004510_myositis1.17991314
54MP0004808_abnormal_hematopoietic_stem1.17940603
55MP0000465_gastrointestinal_hemorrhage1.17066009
56MP0003866_abnormal_defecation1.14130499
57MP0005076_abnormal_cell_differentiation1.13312416
58MP0009840_abnormal_foam_cell1.09401652
59MP0002933_joint_inflammation1.05220332
60MP0003828_pulmonary_edema1.02990683
61MP0003075_altered_response_to1.02888891
62MP0003656_abnormal_erythrocyte_physiolo1.02621930
63MP0002998_abnormal_bone_remodeling1.00398968
64MP0002019_abnormal_tumor_incidence1.00218616
65MP0009764_decreased_sensitivity_to0.99323188
66MP0003183_abnormal_peptide_metabolism0.93697677
67MP0003705_abnormal_hypodermis_morpholog0.91377693
68MP0005075_abnormal_melanosome_morpholog0.88666950
69MP0002006_tumorigenesis0.87813070
70MP0000015_abnormal_ear_pigmentation0.87672710
71MP0005390_skeleton_phenotype0.86663299
72MP0004185_abnormal_adipocyte_glucose0.84787406
73MP0003566_abnormal_cell_adhesion0.83749573
74MP0001851_eye_inflammation0.82442776
75MP0004381_abnormal_hair_follicle0.82404983
76MP0000343_altered_response_to0.82369851
77MP0003448_altered_tumor_morphology0.80557143
78MP0000313_abnormal_cell_death0.78774917
79MP0009763_increased_sensitivity_to0.73952315
80MP0010307_abnormal_tumor_latency0.72659512
81MP0003795_abnormal_bone_structure0.72370876
82MP0000609_abnormal_liver_physiology0.71620131
83MP0002877_abnormal_melanocyte_morpholog0.71469337
84MP0001663_abnormal_digestive_system0.69949808
85MP0003453_abnormal_keratinocyte_physiol0.69727901
86MP0005166_decreased_susceptibility_to0.68488584
87MP0003091_abnormal_cell_migration0.68096946
88MP0006035_abnormal_mitochondrial_morpho0.65975648
89MP0008004_abnormal_stomach_pH0.65890949
90MP0009931_abnormal_skin_appearance0.64921868
91MP0006036_abnormal_mitochondrial_physio0.64850955
92MP0005621_abnormal_cell_physiology0.63218565
93MP0005319_abnormal_enzyme/_coenzyme0.62835381
94MP0005501_abnormal_skin_physiology0.62513626
95MP0003077_abnormal_cell_cycle0.59481097
96MP0000249_abnormal_blood_vessel0.59053238
97MP0003111_abnormal_nucleus_morphology0.59022750
98MP0003221_abnormal_cardiomyocyte_apopto0.58551835
99MP0005375_adipose_tissue_phenotype0.58202871
100MP0002009_preneoplasia0.57827232

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.89521821
2Recurrent abscess formation (HP:0002722)4.41840332
3Agammaglobulinemia (HP:0004432)4.25966017
4Recurrent bacterial skin infections (HP:0005406)4.12805818
5Abnormal delayed hypersensitivity skin test (HP:0002963)4.12690160
6Abnormality of macrophages (HP:0004311)4.05330118
7Meningitis (HP:0001287)4.03043523
8Cellulitis (HP:0100658)3.86284221
9Chronic obstructive pulmonary disease (HP:0006510)3.81366321
10Obstructive lung disease (HP:0006536)3.81366321
11Colitis (HP:0002583)3.80336302
12Panhypogammaglobulinemia (HP:0003139)3.78921407
13Gastrointestinal inflammation (HP:0004386)3.78007998
14Recurrent viral infections (HP:0004429)3.77038625
15Inflammation of the large intestine (HP:0002037)3.72334037
16Mediastinal lymphadenopathy (HP:0100721)3.72332784
17Myositis (HP:0100614)3.56379861
18Recurrent fungal infections (HP:0002841)3.55572234
19Elevated erythrocyte sedimentation rate (HP:0003565)3.54878241
20Chronic mucocutaneous candidiasis (HP:0002728)3.44227722
21Recurrent cutaneous fungal infections (HP:0011370)3.44227722
22Stomatitis (HP:0010280)3.39405296
23Gastrointestinal stroma tumor (HP:0100723)3.32396444
24Recurrent gram-negative bacterial infections (HP:0005420)3.23467198
25Orchitis (HP:0100796)3.20429661
26Vasculitis (HP:0002633)3.18803182
27Abnormality of T cell physiology (HP:0011840)3.17980225
28Increased IgE level (HP:0003212)3.17692766
29Recurrent skin infections (HP:0001581)3.12471900
30Encephalitis (HP:0002383)3.11172419
31Gastrointestinal infarctions (HP:0005244)2.95196722
32Lymphopenia (HP:0001888)2.83663651
33Optic neuritis (HP:0100653)2.83473974
34Retrobulbar optic neuritis (HP:0100654)2.83473974
35Abnormality of T cells (HP:0002843)2.71924351
36Gingivitis (HP:0000230)2.71609387
37Viral hepatitis (HP:0006562)2.71438495
38Verrucae (HP:0200043)2.70596479
39Papilloma (HP:0012740)2.70596479
40Abnormality of cells of the lymphoid lineage (HP:0012140)2.69611674
41Osteomyelitis (HP:0002754)2.68204495
42Urticaria (HP:0001025)2.66880990
43Increased IgM level (HP:0003496)2.59032670
44Prolonged bleeding time (HP:0003010)2.57646294
45Petechiae (HP:0000967)2.56885454
46Recurrent sinusitis (HP:0011108)2.51218833
47Chest pain (HP:0100749)2.51141270
48Fatigue (HP:0012378)2.49213319
49Recurrent lower respiratory tract infections (HP:0002783)2.46971348
50Pustule (HP:0200039)2.45303444
51Spontaneous hematomas (HP:0007420)2.43638583
52Emphysema (HP:0002097)2.42416072
53Hepatosplenomegaly (HP:0001433)2.41743102
54Hypertensive crisis (HP:0100735)2.36542542
55Sepsis (HP:0100806)2.30707551
56Pulmonary infiltrates (HP:0002113)2.29928388
57Restrictive lung disease (HP:0002091)2.26268791
58IgM deficiency (HP:0002850)2.23877521
59Epistaxis (HP:0000421)2.21711759
60Increased cerebral lipofuscin (HP:0011813)2.19736161
61Hypergammaglobulinemia (HP:0010702)2.18934377
62Granulocytopenia (HP:0001913)2.15618648
63Increased serum ferritin (HP:0003281)2.13484285
64Purpura (HP:0000979)2.12987136
65T lymphocytopenia (HP:0005403)2.12907575
66Episodic fever (HP:0001954)2.12039816
67Premature loss of primary teeth (HP:0006323)2.10451577
68IgG deficiency (HP:0004315)2.07948428
69Recurrent bronchitis (HP:0002837)2.06219013
70Ragged-red muscle fibers (HP:0003200)2.05246618
71Increased neuronal autofluorescent lipopigment (HP:0002074)2.04904623
72Recurrent pneumonia (HP:0006532)2.04558769
73Keratoconjunctivitis sicca (HP:0001097)2.02762668
74Skin rash (HP:0000988)2.00595919
75Lymphoma (HP:0002665)2.00448242
76Arterial thrombosis (HP:0004420)2.00264608
77Hypochromic anemia (HP:0001931)1.99804994
78Dysostosis multiplex (HP:0000943)1.99646834
79Autoimmune hemolytic anemia (HP:0001890)1.97988844
80Hemoptysis (HP:0002105)1.97086129
81Loss of speech (HP:0002371)1.96317429
82Abnormality of T cell number (HP:0011839)1.95187118
83Skin ulcer (HP:0200042)1.94358859
84Abnormality of glycolipid metabolism (HP:0010969)1.93091522
85Abnormality of liposaccharide metabolism (HP:0010968)1.93091522
86Abnormality of glycosphingolipid metabolism (HP:0004343)1.93091522
87Glomerulopathy (HP:0100820)1.91953527
88Vertebral compression fractures (HP:0002953)1.91386034
89Anorexia (HP:0002039)1.86212430
90IgA deficiency (HP:0002720)1.85936871
91Progressive external ophthalmoplegia (HP:0000590)1.82262381
92Abnormality of the prostate (HP:0008775)1.78620188
93Gingival bleeding (HP:0000225)1.78269666
94Arthralgia (HP:0002829)1.77932374
95Increased connective tissue (HP:0009025)1.76883618
96Microvesicular hepatic steatosis (HP:0001414)1.76257313
97Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.75318467
98Abnormality of the pleura (HP:0002103)1.74552713
99Centrally nucleated skeletal muscle fibers (HP:0003687)1.74173859
100Leukocytosis (HP:0001974)1.73662236

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.18360345
2ERN13.95805115
3SMG13.09473918
4IRAK42.92309498
5PRPF4B2.91523728
6RIPK42.87430680
7MAP2K32.50522755
8TRIB32.44974077
9TYK22.07457248
10TESK22.05876232
11BLK2.05029890
12MAP3K111.91010874
13TBK11.90899661
14GRK61.88004888
15IRAK31.80838172
16TNK21.80552721
17MAP3K141.75965562
18TAOK21.66347087
19SIK11.66329581
20CSF1R1.65315013
21BTK1.59634979
22EPHB11.58709827
23NME21.57652150
24TAOK11.50126257
25CSK1.47889443
26SIK31.42660454
27ZAP701.41243047
28TXK1.34864350
29JAK31.34573209
30EEF2K1.33658597
31IKBKB1.28090404
32IKBKE1.27267908
33SYK1.27116711
34MAP3K31.26858582
35VRK21.26692157
36MAP3K101.25997080
37CDK121.24210791
38FES1.21815891
39HCK1.14073358
40SIK21.03805815
41KDR1.02719134
42ICK1.02319189
43LYN0.99968562
44PRKD20.97901640
45CDC42BPA0.97770049
46ARAF0.97450912
47MAP3K10.96774272
48ITK0.91108545
49MAPK110.90060154
50FGR0.88702925
51JAK10.86832576
52PTK60.84850906
53TESK10.82543047
54LRRK20.82329770
55CDK40.81364446
56MAP3K130.81234140
57IRAK20.81137640
58STK100.80526976
59LCK0.78602376
60FGFR40.77237672
61KIT0.74521240
62CLK10.72927248
63PIM20.70142266
64MARK30.68781689
65MAP2K20.68590902
66TEC0.67650762
67MARK20.67060574
68IRAK10.65746826
69TAOK30.65694941
70MAPK120.62457367
71HIPK20.62193918
72MAP3K80.60892110
73MAPKAPK20.58166667
74PKN20.57329443
75PDPK10.56176815
76PDK10.54415053
77CDK80.52237979
78MAPK70.51342241
79PAK40.50331091
80BRAF0.50063775
81RPS6KC10.49612679
82RPS6KL10.49612679
83CHUK0.49398190
84CDC70.47362365
85MST40.46556736
86KSR20.45590556
87JAK20.45426444
88MAPK40.44584459
89MATK0.40896643
90CDK90.39455655
91MAPKAPK30.37174895
92CDK70.36705601
93PRKCQ0.35465798
94RPS6KA10.34613912
95RPS6KA60.32913500
96MAP2K60.31004524
97PASK0.30581724
98FYN0.29999762
99TTN0.29862170
100PIM10.29262870

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.13823082
2B cell receptor signaling pathway_Homo sapiens_hsa046622.86980386
3Leishmaniasis_Homo sapiens_hsa051402.54929618
4Osteoclast differentiation_Homo sapiens_hsa043802.49056631
5Allograft rejection_Homo sapiens_hsa053302.45552181
6Other glycan degradation_Homo sapiens_hsa005112.31136208
7Graft-versus-host disease_Homo sapiens_hsa053322.26028611
8Autoimmune thyroid disease_Homo sapiens_hsa053202.07971810
9Antigen processing and presentation_Homo sapiens_hsa046122.04137660
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.99661528
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.97943740
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.97093775
13Acute myeloid leukemia_Homo sapiens_hsa052211.89648346
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.83355621
15Tuberculosis_Homo sapiens_hsa051521.83173022
16Measles_Homo sapiens_hsa051621.83099565
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.81538136
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.77854711
19Herpes simplex infection_Homo sapiens_hsa051681.72388247
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.70076873
21Malaria_Homo sapiens_hsa051441.64957524
22T cell receptor signaling pathway_Homo sapiens_hsa046601.64026041
23Staphylococcus aureus infection_Homo sapiens_hsa051501.63752263
24Type I diabetes mellitus_Homo sapiens_hsa049401.58816287
25Toxoplasmosis_Homo sapiens_hsa051451.53014454
26Influenza A_Homo sapiens_hsa051641.52961550
27Hematopoietic cell lineage_Homo sapiens_hsa046401.51482727
28Viral myocarditis_Homo sapiens_hsa054161.48995909
29Epstein-Barr virus infection_Homo sapiens_hsa051691.41192689
30Non-small cell lung cancer_Homo sapiens_hsa052231.39480885
31Hepatitis B_Homo sapiens_hsa051611.38455053
32Asthma_Homo sapiens_hsa053101.38071577
33Chronic myeloid leukemia_Homo sapiens_hsa052201.36771728
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.36301901
35Rheumatoid arthritis_Homo sapiens_hsa053231.33601395
36DNA replication_Homo sapiens_hsa030301.29343401
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.27927832
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27297312
39Legionellosis_Homo sapiens_hsa051341.26879908
40Apoptosis_Homo sapiens_hsa042101.25322346
41TNF signaling pathway_Homo sapiens_hsa046681.24572430
42Pancreatic cancer_Homo sapiens_hsa052121.18825193
43Shigellosis_Homo sapiens_hsa051311.18070798
44NOD-like receptor signaling pathway_Homo sapiens_hsa046211.17488693
45Viral carcinogenesis_Homo sapiens_hsa052031.12641494
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.10695777
47Hepatitis C_Homo sapiens_hsa051601.10208426
48HTLV-I infection_Homo sapiens_hsa051661.07963941
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.01945827
50Bladder cancer_Homo sapiens_hsa052191.00357836
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.98792736
52Pentose phosphate pathway_Homo sapiens_hsa000300.95873580
53Salmonella infection_Homo sapiens_hsa051320.94940995
54Lysosome_Homo sapiens_hsa041420.94319406
55Notch signaling pathway_Homo sapiens_hsa043300.93164636
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.90728868
57Chemokine signaling pathway_Homo sapiens_hsa040620.89582439
58VEGF signaling pathway_Homo sapiens_hsa043700.89127329
59African trypanosomiasis_Homo sapiens_hsa051430.88325916
60Phagosome_Homo sapiens_hsa041450.87338147
61Sulfur relay system_Homo sapiens_hsa041220.81823614
62Base excision repair_Homo sapiens_hsa034100.80900090
63Proteasome_Homo sapiens_hsa030500.80418395
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.75688239
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.72297574
66Renal cell carcinoma_Homo sapiens_hsa052110.69981970
67Pertussis_Homo sapiens_hsa051330.69237967
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65644386
69Endocytosis_Homo sapiens_hsa041440.64281238
70mTOR signaling pathway_Homo sapiens_hsa041500.64037386
71Inositol phosphate metabolism_Homo sapiens_hsa005620.63414304
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61191832
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60811778
74Systemic lupus erythematosus_Homo sapiens_hsa053220.60076644
75Platelet activation_Homo sapiens_hsa046110.58642706
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58320611
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.58026654
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57336385
79Galactose metabolism_Homo sapiens_hsa000520.57104325
80Fructose and mannose metabolism_Homo sapiens_hsa000510.56613773
81HIF-1 signaling pathway_Homo sapiens_hsa040660.56508465
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55961796
83Spliceosome_Homo sapiens_hsa030400.55168420
84Colorectal cancer_Homo sapiens_hsa052100.52702506
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52080038
86Endometrial cancer_Homo sapiens_hsa052130.52013093
87Prostate cancer_Homo sapiens_hsa052150.48338781
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47414668
89Small cell lung cancer_Homo sapiens_hsa052220.46477227
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46411005
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.44799093
92Prolactin signaling pathway_Homo sapiens_hsa049170.43999044
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.42773548
94FoxO signaling pathway_Homo sapiens_hsa040680.38126553
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37315480
96Insulin signaling pathway_Homo sapiens_hsa049100.36396124
97Pyrimidine metabolism_Homo sapiens_hsa002400.35768842
98Amoebiasis_Homo sapiens_hsa051460.35368798
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35095649
100Mismatch repair_Homo sapiens_hsa034300.34103743

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