BPGM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: 2,3-diphosphoglycerate (2,3-DPG) is a small molecule found at high concentrations in red blood cells where it binds to and decreases the oxygen affinity of hemoglobin. This gene encodes a multifunctional enzyme that catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. The enzyme also has phosphoglycerate phosphomutase activity. Deficiency of this enzyme increases the affinity of cells for oxygen. Mutations in this gene result in hemolytic anemia. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)6.50735282
2attachment of spindle microtubules to kinetochore (GO:0008608)6.29087012
3ensheathment of neurons (GO:0007272)5.89932639
4axon ensheathment (GO:0008366)5.89932639
5myelination (GO:0042552)5.86421822
6glycerophospholipid catabolic process (GO:0046475)5.58956874
7protoporphyrinogen IX metabolic process (GO:0046501)5.50795003
8protein K11-linked deubiquitination (GO:0035871)5.30604723
9mitotic metaphase plate congression (GO:0007080)5.25821061
10hemoglobin metabolic process (GO:0020027)5.03613374
11oxygen transport (GO:0015671)5.02905558
12protoporphyrinogen IX biosynthetic process (GO:0006782)5.01307109
13response to methylmercury (GO:0051597)4.94070721
14long-chain fatty acid biosynthetic process (GO:0042759)4.84484106
15apical protein localization (GO:0045176)4.76603741
16regulation of meiosis I (GO:0060631)4.58628054
17myelin maintenance (GO:0043217)4.57204744
18glycine transport (GO:0015816)4.49336795
19regulation of female gonad development (GO:2000194)4.36293715
20eye photoreceptor cell differentiation (GO:0001754)4.35538199
21photoreceptor cell differentiation (GO:0046530)4.35538199
22metaphase plate congression (GO:0051310)4.32486161
23establishment of chromosome localization (GO:0051303)4.26636195
24asymmetric protein localization (GO:0008105)4.22834909
25production of molecular mediator involved in inflammatory response (GO:0002532)4.22801255
26negative regulation of protein localization to cell surface (GO:2000009)4.21316521
27histone mRNA catabolic process (GO:0071044)4.21298778
28establishment of mitochondrion localization (GO:0051654)4.21043131
29negative regulation of neurotransmitter transport (GO:0051589)4.20212153
30cholesterol biosynthetic process (GO:0006695)4.19271150
31nuclear pore organization (GO:0006999)4.16652559
32gas transport (GO:0015669)4.06283874
33negative regulation of neurotransmitter secretion (GO:0046929)3.98283295
34membrane tubulation (GO:0097320)3.93756950
35oligodendrocyte differentiation (GO:0048709)3.88914481
36retinal cone cell development (GO:0046549)3.87109735
37microtubule polymerization or depolymerization (GO:0031109)3.82981753
38regulation of response to osmotic stress (GO:0047484)3.80720093
39negative regulation of execution phase of apoptosis (GO:1900118)3.79365701
40positive regulation of humoral immune response (GO:0002922)3.79015375
41regulation of translation, ncRNA-mediated (GO:0045974)3.75897448
42negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.75897448
43negative regulation of translation, ncRNA-mediated (GO:0040033)3.75897448
44regulation of cell maturation (GO:1903429)3.74010597
45microtubule severing (GO:0051013)3.71902382
46sterol biosynthetic process (GO:0016126)3.66654333
47creatine metabolic process (GO:0006600)3.66027095
48isoprenoid biosynthetic process (GO:0008299)3.62927991
49regulation of collateral sprouting (GO:0048670)3.61478873
50oocyte development (GO:0048599)3.60129986
51positive regulation of oligodendrocyte differentiation (GO:0048714)3.53044053
52amyloid precursor protein metabolic process (GO:0042982)3.52180377
53heme metabolic process (GO:0042168)3.51260513
54GPI anchor biosynthetic process (GO:0006506)3.48847597
55regulation of DNA methylation (GO:0044030)3.46300200
56negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.46134516
57protein polyglutamylation (GO:0018095)3.37968740
58multicellular organism reproduction (GO:0032504)3.36167246
59negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)3.35664204
60response to lead ion (GO:0010288)3.34416282
61chaperone-mediated protein transport (GO:0072321)3.32707893
62regulation of exit from mitosis (GO:0007096)3.32139710
63response to redox state (GO:0051775)3.28471350
64histone mRNA metabolic process (GO:0008334)3.27928866
65GPI anchor metabolic process (GO:0006505)3.27332865
66meiotic cell cycle (GO:0051321)3.26886377
67protein targeting to Golgi (GO:0000042)3.21813433
68substantia nigra development (GO:0021762)3.20879066
69piRNA metabolic process (GO:0034587)3.20714451
70preassembly of GPI anchor in ER membrane (GO:0016254)3.20597303
71import into cell (GO:0098657)3.20476197
72N-terminal protein amino acid acetylation (GO:0006474)3.17467558
73regulation of acrosome reaction (GO:0060046)3.16951511
74heme biosynthetic process (GO:0006783)3.16163043
75porphyrin-containing compound biosynthetic process (GO:0006779)3.15722062
76peptidyl-cysteine modification (GO:0018198)3.12717223
77L-amino acid import (GO:0043092)3.11464340
78* erythrocyte development (GO:0048821)3.10691894
79positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.08992454
80positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.08992454
81positive regulation of mitotic sister chromatid separation (GO:1901970)3.08992454
82protein neddylation (GO:0045116)2.98667204
83hepatocyte apoptotic process (GO:0097284)2.97242510
84presynaptic membrane organization (GO:0097090)2.96791229
85protein palmitoylation (GO:0018345)2.96680807
86positive regulation of neurological system process (GO:0031646)2.94807836
87centriole assembly (GO:0098534)2.91816165
88astrocyte development (GO:0014002)2.90960513
89peripheral nervous system axon ensheathment (GO:0032292)2.89858742
90myelination in peripheral nervous system (GO:0022011)2.89858742
91centriole replication (GO:0007099)2.87441039
92retrograde transport, vesicle recycling within Golgi (GO:0000301)2.86774209
93dopamine biosynthetic process (GO:0042416)2.86202538
94tetrapyrrole biosynthetic process (GO:0033014)2.85951760
95establishment of protein localization to Golgi (GO:0072600)2.85699969
96magnesium ion transport (GO:0015693)2.84768922
97regulation of autophagic vacuole assembly (GO:2000785)2.83689390
98regulation of meiosis (GO:0040020)2.81835797
99female gamete generation (GO:0007292)2.81095241
100protein K63-linked deubiquitination (GO:0070536)2.80294838
101adult walking behavior (GO:0007628)2.80210917
102heme transport (GO:0015886)2.79514829
103response to lipoprotein particle (GO:0055094)2.79226656
104establishment of spindle localization (GO:0051293)2.78361319
105negative regulation of cAMP-mediated signaling (GO:0043951)2.76282179
106microtubule anchoring (GO:0034453)2.76232538
107neuron cell-cell adhesion (GO:0007158)2.75713105
108long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.75477846
109organ growth (GO:0035265)2.75020455
110amyloid precursor protein catabolic process (GO:0042987)2.74970225
111protein K48-linked deubiquitination (GO:0071108)2.73068954
112positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.73040415
113histone H3-K9 demethylation (GO:0033169)2.72233296
114negative regulation of B cell proliferation (GO:0030889)2.71872636
115regulation of lipoprotein metabolic process (GO:0050746)2.71809371
116oogenesis (GO:0048477)2.71019481
117phosphatidylinositol acyl-chain remodeling (GO:0036149)2.70367841
118Golgi to endosome transport (GO:0006895)2.70111933
119limb bud formation (GO:0060174)2.69736362
120iron coordination entity transport (GO:1901678)2.68900791
121regulation of fibroblast apoptotic process (GO:2000269)2.67922148
122centrosome localization (GO:0051642)2.67288885
123erythrocyte maturation (GO:0043249)2.67243962
124mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.67034041
125positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.67034041
126cullin deneddylation (GO:0010388)2.67004112
127response to insecticide (GO:0017085)2.66267858
128DNA methylation involved in gamete generation (GO:0043046)2.66017712
129negative regulation of reproductive process (GO:2000242)2.65556663
130regulation of steroid hormone secretion (GO:2000831)2.64507074
131protein deneddylation (GO:0000338)2.63417356
132mitochondrion degradation (GO:0000422)2.62850892
133regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.62288078
134regulation of spindle organization (GO:0090224)2.62119127
135neurotransmitter uptake (GO:0001504)2.60667256
136regulation of vacuole organization (GO:0044088)2.60626816
137oocyte maturation (GO:0001556)2.57841243
138anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.57203071
139peptidyl-tyrosine autophosphorylation (GO:0038083)2.56968807
140regulation of histone H3-K9 methylation (GO:0051570)2.54970458
141* myeloid cell development (GO:0061515)2.53649180
142protein K11-linked ubiquitination (GO:0070979)2.53432656
143establishment of spindle orientation (GO:0051294)2.52936902
144positive regulation of erythrocyte differentiation (GO:0045648)2.52768636
145proteasome assembly (GO:0043248)2.52084847
146nerve growth factor signaling pathway (GO:0038180)2.51879763
147gene silencing by RNA (GO:0031047)2.50773910
148porphyrin-containing compound metabolic process (GO:0006778)2.50344365
149negative regulation of inclusion body assembly (GO:0090084)2.49930426
150microglial cell activation (GO:0001774)2.49791658
151fertilization (GO:0009566)2.49326338
152regulation of platelet aggregation (GO:0090330)2.48815679
153long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.48376580
154peripheral nervous system development (GO:0007422)2.48216497
155CENP-A containing nucleosome assembly (GO:0034080)2.47946134
156presynaptic membrane assembly (GO:0097105)2.47847312
157purine-containing compound salvage (GO:0043101)2.47819059
158regulation of meiotic cell cycle (GO:0051445)2.47266960
159L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.47027033
160positive regulation of interleukin-1 beta secretion (GO:0050718)2.46976444
161organelle membrane fusion (GO:0090174)2.46611960
162vesicle fusion (GO:0006906)2.45397340
163cerebral cortex radially oriented cell migration (GO:0021799)2.45146438
164reproduction (GO:0000003)2.45145141
165regulation of dopamine metabolic process (GO:0042053)2.44574398
166regulation of catecholamine metabolic process (GO:0042069)2.44574398
167phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.43955272
168positive regulation of interleukin-8 secretion (GO:2000484)2.43664264
169neutrophil mediated immunity (GO:0002446)2.42619615
170intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)2.42238254
171negative regulation of signal transduction by p53 class mediator (GO:1901797)2.41086916
172regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.37472843
173spermatid nucleus differentiation (GO:0007289)2.36795600
174regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079)2.35612290
175male meiosis I (GO:0007141)2.35550518
176axon ensheathment in central nervous system (GO:0032291)10.4240947
177central nervous system myelination (GO:0022010)10.4240947

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.30823858
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.17135779
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.06897039
4GBX2_23144817_ChIP-Seq_PC3_Human2.74424909
5* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.40094506
6* GABP_17652178_ChIP-ChIP_JURKAT_Human2.15216294
7ELK1_19687146_ChIP-ChIP_HELA_Human2.10451131
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.09461875
9GATA1_26923725_Chip-Seq_HPCs_Mouse2.04727154
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.04468061
11VDR_22108803_ChIP-Seq_LS180_Human2.02334158
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.99716777
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.99578921
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97482314
15ELF1_17652178_ChIP-ChIP_JURKAT_Human1.93268825
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92986205
17NOTCH1_21737748_ChIP-Seq_TLL_Human1.88496130
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85770459
19BMI1_23680149_ChIP-Seq_NPCS_Mouse1.85683979
20JARID2_20064375_ChIP-Seq_MESCs_Mouse1.85662271
21GATA1_22025678_ChIP-Seq_K562_Human1.85583958
22STAT6_21828071_ChIP-Seq_BEAS2B_Human1.84230858
23BP1_19119308_ChIP-ChIP_Hs578T_Human1.81679206
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.80175252
25OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.78148805
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73765898
27TAF15_26573619_Chip-Seq_HEK293_Human1.71856565
28FUS_26573619_Chip-Seq_HEK293_Human1.67888699
29RNF2_27304074_Chip-Seq_NSC_Mouse1.67850137
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.66447248
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66422907
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.66277685
33AR_21572438_ChIP-Seq_LNCaP_Human1.65821201
34* VDR_23849224_ChIP-Seq_CD4+_Human1.64753403
35SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.64250010
36RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.63729728
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.63299749
38SALL4_22934838_ChIP-ChIP_CD34+_Human1.60800202
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.59116712
40EZH2_27294783_Chip-Seq_NPCs_Mouse1.58471463
41STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.58098472
42IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.57751965
43IGF1R_20145208_ChIP-Seq_DFB_Human1.57518044
44SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.57161628
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56691672
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.55098644
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55080070
48MTF2_20144788_ChIP-Seq_MESCs_Mouse1.54936781
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.54585431
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54521334
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.52761756
52EZH2_18974828_ChIP-Seq_MESCs_Mouse1.52335110
53RNF2_18974828_ChIP-Seq_MESCs_Mouse1.52335110
54SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.51172088
55ER_23166858_ChIP-Seq_MCF-7_Human1.49458729
56TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48850462
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.47678423
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.47225813
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46359338
60RNF2_27304074_Chip-Seq_ESCs_Mouse1.44119064
61HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.43618513
62FOXM1_23109430_ChIP-Seq_U2OS_Human1.43349129
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.42722580
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.40089699
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.39635950
66RUNX_20019798_ChIP-Seq_JUKART_Human1.39388746
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38548690
68* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.38339931
69PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.37171054
70IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37113023
71CBP_20019798_ChIP-Seq_JUKART_Human1.37113023
72WT1_19549856_ChIP-ChIP_CCG9911_Human1.36792404
73P53_22127205_ChIP-Seq_FIBROBLAST_Human1.36376696
74LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34797646
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34449377
76SUZ12_27294783_Chip-Seq_ESCs_Mouse1.33702100
77STAT3_23295773_ChIP-Seq_U87_Human1.32964734
78E2F4_17652178_ChIP-ChIP_JURKAT_Human1.31617769
79* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.31582298
80* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.31510067
81SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30571729
82IRF1_19129219_ChIP-ChIP_H3396_Human1.30369247
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30221030
84FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.30081526
85TAL1_26923725_Chip-Seq_HPCs_Mouse1.28031422
86EED_16625203_ChIP-ChIP_MESCs_Mouse1.27209379
87POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26555646
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25787839
89* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25759059
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.25227838
91SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25199009
92MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24992562
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24756088
94* GATA2_19941826_ChIP-Seq_K562_Human1.24691021
95ZNF274_21170338_ChIP-Seq_K562_Hela1.24358650
96FOXP3_21729870_ChIP-Seq_TREG_Human1.23405205
97PIAS1_25552417_ChIP-Seq_VCAP_Human1.21336604
98SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.19858075
99SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.19526358
100FOXM1_26456572_ChIP-Seq_MCF-7_Human1.19407063
101EOMES_21245162_ChIP-Seq_HESCs_Human1.19170199
102MYB_21317192_ChIP-Seq_ERMYB_Mouse1.19104074
103STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.18415097
104IRF8_21731497_ChIP-ChIP_J774_Mouse1.18267795
105PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16230685
106CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15652790
107PRDM14_20953172_ChIP-Seq_ESCs_Human1.15192108
108CDX2_22108803_ChIP-Seq_LS180_Human1.14182956
109MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.13645656
110NFE2_27457419_Chip-Seq_LIVER_Mouse1.13509756
111GATA1_19941826_ChIP-Seq_K562_Human1.13049707
112HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.13039218
113NANOG_18555785_Chip-Seq_ESCs_Mouse1.12544627
114SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.11874271
115JARID2_20075857_ChIP-Seq_MESCs_Mouse1.11681604
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11528566
117SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11439015
118SOX2_16153702_ChIP-ChIP_HESCs_Human1.11407840
119LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11235066
120SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.10253945
121CRX_20693478_ChIP-Seq_RETINA_Mouse1.10056109
122PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08560998
123TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06667220
124AR_25329375_ChIP-Seq_VCAP_Human1.06490513
125RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05396990
126PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05179425
127CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04319553
128FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.03908557
129SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03688813
130SMAD4_21799915_ChIP-Seq_A2780_Human1.03686320
131CMYC_18555785_Chip-Seq_ESCs_Mouse1.03640463
132SCL_19346495_ChIP-Seq_HPC-7_Human1.03569650
133KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03350276
134IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03245165
135P300_19829295_ChIP-Seq_ESCs_Human1.03239815
136TP53_16413492_ChIP-PET_HCT116_Human1.03206290
137TCF4_23295773_ChIP-Seq_U87_Human1.02493045
138* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.02152161
139FLI1_21867929_ChIP-Seq_TH2_Mouse1.02137478
140SMRT_27268052_Chip-Seq_Bcells_Human1.02122035
141AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01774629
142OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01611655
143EP300_21415370_ChIP-Seq_HL-1_Mouse1.00839274
144KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.00557736
145KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.00557736
146KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.00557736
147TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00519715
148E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00171518
149SMAD_19615063_ChIP-ChIP_OVARY_Human0.99793099
150* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.99170992
151PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99097569
152EWS_26573619_Chip-Seq_HEK293_Human0.98522518
153SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97846070
154* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96487571
155RARB_27405468_Chip-Seq_BRAIN_Mouse0.95840131
156RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95772280
157NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.95297558
158NANOG_19829295_ChIP-Seq_ESCs_Human0.94051424
159SOX2_19829295_ChIP-Seq_ESCs_Human0.94051424
160* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94002810
161EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.93448058
162VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93007033
163SMAD4_21741376_ChIP-Seq_EPCs_Human0.91534859
164EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91461177
165TBL1_22424771_ChIP-Seq_293T_Human0.90406290
166HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.90385780

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.03179450
2MP0000920_abnormal_myelination4.02119103
3MP0003950_abnormal_plasma_membrane3.93382851
4MP0004147_increased_porphyrin_level3.64162480
5MP0003718_maternal_effect3.59479917
6MP0001529_abnormal_vocalization3.51862597
7MP0003656_abnormal_erythrocyte_physiolo3.45773857
8MP0003880_abnormal_central_pattern3.14603745
9MP0005451_abnormal_body_composition3.06089368
10MP0004270_analgesia2.91259794
11MP0001905_abnormal_dopamine_level2.89556256
12MP0005083_abnormal_biliary_tract2.35065793
13MP0003221_abnormal_cardiomyocyte_apopto2.28393267
14MP0008058_abnormal_DNA_repair2.26910437
15MP0003329_amyloid_beta_deposits2.21680161
16MP0002653_abnormal_ependyma_morphology2.15699422
17MP0001485_abnormal_pinna_reflex2.15161531
18MP0003186_abnormal_redox_activity2.07224338
19MP0004742_abnormal_vestibular_system2.00474781
20MP0005410_abnormal_fertilization1.98682512
21MP0008057_abnormal_DNA_replication1.94788262
22MP0000778_abnormal_nervous_system1.94025280
23MP0003136_yellow_coat_color1.92537802
24MP0004885_abnormal_endolymph1.88574743
25MP0003828_pulmonary_edema1.86258118
26MP0001486_abnormal_startle_reflex1.83748261
27MP0004043_abnormal_pH_regulation1.83498646
28MP0003690_abnormal_glial_cell1.80886652
29MP0002272_abnormal_nervous_system1.79294963
30MP0004142_abnormal_muscle_tone1.72310551
31MP0005075_abnormal_melanosome_morpholog1.69098953
32MP0002734_abnormal_mechanical_nocicepti1.68708203
33MP0004883_abnormal_blood_vessel1.67444151
34MP0004859_abnormal_synaptic_plasticity1.67306786
35MP0003634_abnormal_glial_cell1.64956888
36MP0003787_abnormal_imprinting1.64467487
37MP0003632_abnormal_nervous_system1.63160959
38MP0004145_abnormal_muscle_electrophysio1.61466411
39MP0000462_abnormal_digestive_system1.61341997
40MP0002229_neurodegeneration1.59717108
41MP0006072_abnormal_retinal_apoptosis1.59464905
42MP0003937_abnormal_limbs/digits/tail_de1.57264852
43MP0008260_abnormal_autophagy1.55660808
44MP0005551_abnormal_eye_electrophysiolog1.55269175
45MP0009697_abnormal_copulation1.55083296
46MP0009785_altered_susceptibility_to1.53868660
47MP0008877_abnormal_DNA_methylation1.47205652
48MP0002138_abnormal_hepatobiliary_system1.47160640
49MP0003077_abnormal_cell_cycle1.46284935
50MP0000015_abnormal_ear_pigmentation1.42749448
51MP0002102_abnormal_ear_morphology1.41385958
52MP0002064_seizures1.41021477
53MP0003724_increased_susceptibility_to1.37542777
54MP0006276_abnormal_autonomic_nervous1.36395110
55MP0000383_abnormal_hair_follicle1.35859718
56MP0010678_abnormal_skin_adnexa1.34537028
57MP0005408_hypopigmentation1.33770419
58MP0010307_abnormal_tumor_latency1.32885316
59MP0003890_abnormal_embryonic-extraembry1.32016103
60MP0006054_spinal_hemorrhage1.31888535
61MP0005423_abnormal_somatic_nervous1.30086113
62MP0005164_abnormal_response_to1.30038880
63MP0001346_abnormal_lacrimal_gland1.29029892
64MP0005171_absent_coat_pigmentation1.28278906
65MP0001929_abnormal_gametogenesis1.26774434
66MP0005395_other_phenotype1.26376555
67MP0001545_abnormal_hematopoietic_system1.26340886
68MP0005397_hematopoietic_system_phenotyp1.26340886
69MP0002752_abnormal_somatic_nervous1.25204495
70MP0003806_abnormal_nucleotide_metabolis1.24662796
71MP0008995_early_reproductive_senescence1.24587536
72MP0002882_abnormal_neuron_morphology1.20833368
73MP0000955_abnormal_spinal_cord1.20809104
74MP0003121_genomic_imprinting1.20655649
75MP0005187_abnormal_penis_morphology1.19508923
76MP0002405_respiratory_system_inflammati1.19326967
77MP0002332_abnormal_exercise_endurance1.17752551
78MP0003786_premature_aging1.16548061
79MP0003635_abnormal_synaptic_transmissio1.16389091
80MP0006082_CNS_inflammation1.14740336
81MP0003699_abnormal_female_reproductive1.14425273
82MP0000566_synostosis1.13146069
83MP0000579_abnormal_nail_morphology1.12836325
84MP0005174_abnormal_tail_pigmentation1.12612716
85MP0005195_abnormal_posterior_eye1.12057012
86MP0001963_abnormal_hearing_physiology1.11362264
87MP0003303_peritoneal_inflammation1.10972432
88MP0003938_abnormal_ear_development1.10960654
89MP0001853_heart_inflammation1.10251324
90MP0002638_abnormal_pupillary_reflex1.08202227
91MP0004264_abnormal_extraembryonic_tissu1.07807018
92MP0002572_abnormal_emotion/affect_behav1.06750262
93MP0005310_abnormal_salivary_gland1.06395135
94MP0002163_abnormal_gland_morphology1.05766432
95MP0009765_abnormal_xenobiotic_induced1.05715641
96MP0002161_abnormal_fertility/fecundity1.04131474
97MP0001970_abnormal_pain_threshold1.04125927
98MP0000631_abnormal_neuroendocrine_gland1.03397116
99MP0009046_muscle_twitch1.02735603
100MP0009745_abnormal_behavioral_response1.01548473
101MP0005394_taste/olfaction_phenotype1.00350748
102MP0005499_abnormal_olfactory_system1.00350748
103MP0004924_abnormal_behavior0.99735359
104MP0005386_behavior/neurological_phenoty0.99735359
105MP0003631_nervous_system_phenotype0.98021645
106MP0003698_abnormal_male_reproductive0.97374632
107MP0002398_abnormal_bone_marrow0.97298778
108MP0002066_abnormal_motor_capabilities/c0.96625836
109MP0001440_abnormal_grooming_behavior0.96128493
110MP0002736_abnormal_nociception_after0.95196374
111MP0002067_abnormal_sensory_capabilities0.94767820
112MP0009764_decreased_sensitivity_to0.94645113
113MP0000653_abnormal_sex_gland0.93883697
114MP0003011_delayed_dark_adaptation0.93819064
115MP0002722_abnormal_immune_system0.93674621
116MP0001119_abnormal_female_reproductive0.93670442
117MP0002095_abnormal_skin_pigmentation0.93414320
118MP0000427_abnormal_hair_cycle0.93396920
119MP0002295_abnormal_pulmonary_circulatio0.93143778
120MP0002063_abnormal_learning/memory/cond0.93077331
121MP0000762_abnormal_tongue_morphology0.91113508
122MP0005253_abnormal_eye_physiology0.91090793
123MP0009250_abnormal_appendicular_skeleto0.88976894
124MP0002152_abnormal_brain_morphology0.88595589
125MP0000749_muscle_degeneration0.88332859
126MP0000689_abnormal_spleen_morphology0.87846132
127MP0000026_abnormal_inner_ear0.86801666
128MP0005389_reproductive_system_phenotype0.86620327
129MP0002733_abnormal_thermal_nociception0.86367540
130MP0003861_abnormal_nervous_system0.85519678
131MP0000372_irregular_coat_pigmentation0.84962357
132MP0003693_abnormal_embryo_hatching0.83840701
133MP0001984_abnormal_olfaction0.81920841
134MP0008789_abnormal_olfactory_epithelium0.81720304
135MP0001968_abnormal_touch/_nociception0.80112174
136MP0002210_abnormal_sex_determination0.79606176
137MP0005621_abnormal_cell_physiology0.78924281
138MP0000647_abnormal_sebaceous_gland0.78828602
139MP0002419_abnormal_innate_immunity0.78269770
140MP0004134_abnormal_chest_morphology0.78154629
141MP0006035_abnormal_mitochondrial_morpho0.77665851
142MP0004185_abnormal_adipocyte_glucose0.77647253
143MP0002420_abnormal_adaptive_immunity0.77194451
144MP0005376_homeostasis/metabolism_phenot0.76971826
145MP0001299_abnormal_eye_distance/0.76272204
146MP0005646_abnormal_pituitary_gland0.76166859
147MP0002723_abnormal_immune_serum0.75729607
148MP0001819_abnormal_immune_cell0.74627470
149MP0003183_abnormal_peptide_metabolism0.74330224
150MP0003315_abnormal_perineum_morphology0.73968025
151MP0005025_abnormal_response_to0.73339369
152MP0006292_abnormal_olfactory_placode0.72945578
153MP0005384_cellular_phenotype0.72471959
154MP0006036_abnormal_mitochondrial_physio0.71862273
155MP0000604_amyloidosis0.71160335
156MP0000685_abnormal_immune_system0.70888925
157MP0004381_abnormal_hair_follicle0.70033824
158MP0002090_abnormal_vision0.69427065
159MP0004036_abnormal_muscle_relaxation0.69164827
160MP0003111_abnormal_nucleus_morphology0.68293790
161MP0004484_altered_response_of0.67699804
162MP0001145_abnormal_male_reproductive0.67254294
163MP0004084_abnormal_cardiac_muscle0.65896044
164MP0003763_abnormal_thymus_physiology0.65626915
165MP0002452_abnormal_antigen_presenting0.65408641
166MP0002972_abnormal_cardiac_muscle0.64704416
167MP0002160_abnormal_reproductive_system0.64638127
168MP0000716_abnormal_immune_system0.64386728
169MP0000343_altered_response_to0.63045713
170MP0002019_abnormal_tumor_incidence0.62774557
171MP0005464_abnormal_platelet_physiology0.62277792
172MP0002148_abnormal_hypersensitivity_rea0.61546355

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.10232583
2Degeneration of the lateral corticospinal tracts (HP:0002314)6.10232583
3Microcytic anemia (HP:0001935)5.27835621
4Neurofibrillary tangles (HP:0002185)5.05947400
5Abnormality of the corticospinal tract (HP:0002492)4.67964860
6Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.56838837
7Hypochromic microcytic anemia (HP:0004840)4.50676648
8Sensory axonal neuropathy (HP:0003390)4.39157176
9Parakeratosis (HP:0001036)4.01064407
10Abnormality of the heme biosynthetic pathway (HP:0010472)4.00618085
11Cerebral hypomyelination (HP:0006808)3.73966122
12Cerebral inclusion bodies (HP:0100314)3.70147982
13Peripheral hypomyelination (HP:0007182)3.69621522
14Abnormality of glycolysis (HP:0004366)3.66450985
15Increased serum pyruvate (HP:0003542)3.66450985
16Thyroid carcinoma (HP:0002890)3.51661214
17T lymphocytopenia (HP:0005403)3.46450534
18Hypochromic anemia (HP:0001931)3.46097303
19Abnormality of T cell number (HP:0011839)3.44138122
20Abnormal auditory evoked potentials (HP:0006958)3.32195829
21Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.23003299
22Insidious onset (HP:0003587)3.21714979
23Termporal pattern (HP:0011008)3.21714979
24* Cholelithiasis (HP:0001081)3.14704261
25Supernumerary spleens (HP:0009799)3.14157061
26Onion bulb formation (HP:0003383)3.03158527
27Spastic gait (HP:0002064)2.95859049
28Retinal dysplasia (HP:0007973)2.91419191
29Anhidrosis (HP:0000970)2.90216682
30Adrenal hypoplasia (HP:0000835)2.85454764
31Supranuclear gaze palsy (HP:0000605)2.83199850
32Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.81459560
33Median cleft lip (HP:0000161)2.80931019
34* Abnormal gallbladder morphology (HP:0012437)2.80008951
35Poikilocytosis (HP:0004447)2.79800252
36Abnormal hemoglobin (HP:0011902)2.78363586
37Male infertility (HP:0003251)2.77349663
38Stomatitis (HP:0010280)2.77273692
39Conjunctival telangiectasia (HP:0000524)2.76650687
40Polycythemia (HP:0001901)2.75601317
41Pelvic girdle muscle weakness (HP:0003749)2.72024572
42Abnormality of the hip-girdle musculature (HP:0001445)2.71339114
43Abnormality of the musculature of the pelvis (HP:0001469)2.71339114
44Aplasia involving bones of the upper limbs (HP:0009823)2.70803752
45Aplasia of the phalanges of the hand (HP:0009802)2.70803752
46Aplasia involving bones of the extremities (HP:0009825)2.70803752
47Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.70394092
48Recurrent bacterial skin infections (HP:0005406)2.68378961
49Paralysis (HP:0003470)2.65182986
50Thickened helices (HP:0000391)2.62050006
51Osteomalacia (HP:0002749)2.61995948
52Morphological abnormality of the inner ear (HP:0011390)2.53459708
53Dysmetria (HP:0001310)2.52210547
54Abnormal hair whorl (HP:0010721)2.52148726
55Volvulus (HP:0002580)2.51875643
56Absent septum pellucidum (HP:0001331)2.47377345
57Ileus (HP:0002595)2.45721668
58Abnormal spermatogenesis (HP:0008669)2.45677531
59CNS hypomyelination (HP:0003429)2.44172746
60Acanthocytosis (HP:0001927)2.43369624
61Leukodystrophy (HP:0002415)2.43134344
62Hypoplastic pelvis (HP:0008839)2.42816363
63Diaphragmatic weakness (HP:0009113)2.41823258
64Toxemia of pregnancy (HP:0100603)2.38551693
65Vaginal atresia (HP:0000148)2.38299237
66Nausea (HP:0002018)2.38080910
67Abnormality of the vasculature of the conjunctiva (HP:0008054)2.37456985
68Pustule (HP:0200039)2.35825894
69Genital tract atresia (HP:0001827)2.33756910
70Intention tremor (HP:0002080)2.33399363
71Myokymia (HP:0002411)2.32550325
72Short tibia (HP:0005736)2.30346877
73Aplastic anemia (HP:0001915)2.29737951
74Anomalous pulmonary venous return (HP:0010772)2.26766677
75Oligodactyly (hands) (HP:0001180)2.26673713
76Premature skin wrinkling (HP:0100678)2.26462872
77Amyotrophic lateral sclerosis (HP:0007354)2.23675363
78Abnormality of the labia minora (HP:0012880)2.20615023
79Lip pit (HP:0100267)2.20047147
80Slow saccadic eye movements (HP:0000514)2.17818055
81Aplasia/Hypoplasia of the fovea (HP:0008060)2.16401966
82Hypoplasia of the fovea (HP:0007750)2.16401966
83Abnormality of the septum pellucidum (HP:0007375)2.14728637
84Ankle clonus (HP:0011448)2.14570548
85Orthostatic hypotension (HP:0001278)2.14064277
86Alacrima (HP:0000522)2.13793107
87Infantile muscular hypotonia (HP:0008947)2.13067716
88Leukocytosis (HP:0001974)2.12712497
89Abnormality of the fovea (HP:0000493)2.11950785
90Gastrointestinal infarctions (HP:0005244)2.11569399
91Autoamputation (HP:0001218)2.11002787
92Recurrent abscess formation (HP:0002722)2.10257821
93Autoimmune hemolytic anemia (HP:0001890)2.09963074
94Aplasia/Hypoplasia of the macula (HP:0008059)2.06606583
95Exertional dyspnea (HP:0002875)2.06457382
96Anteriorly placed anus (HP:0001545)2.05010803
97Spastic paraparesis (HP:0002313)2.04946329
98Muscle fiber splitting (HP:0003555)2.04187201
99Partial agenesis of the corpus callosum (HP:0001338)2.04116844
100Anterior segment dysgenesis (HP:0007700)2.02812341
101Periodontitis (HP:0000704)2.02502324
102Abnormality of the phalanges of the 2nd finger (HP:0009541)2.02249637
103Gait imbalance (HP:0002141)2.01536856
104Aplasia/Hypoplasia of the tongue (HP:0010295)2.00445366
105Atrophy/Degeneration involving motor neurons (HP:0007373)2.00351782
106Degeneration of anterior horn cells (HP:0002398)2.00254307
107Abnormality of the anterior horn cell (HP:0006802)2.00254307
108Albinism (HP:0001022)1.99359679
109Abnormal respiratory motile cilium physiology (HP:0012261)1.96195877
110Renal Fanconi syndrome (HP:0001994)1.95496890
111Cupped ear (HP:0000378)1.95162746
112Postural instability (HP:0002172)1.95024519
113Aplasia/Hypoplasia of the tibia (HP:0005772)1.93405302
114Gonadotropin excess (HP:0000837)1.92004106
115Autoimmune thrombocytopenia (HP:0001973)1.90861117
116Papilledema (HP:0001085)1.90514954
117Medial flaring of the eyebrow (HP:0010747)1.90150084
118Lower limb muscle weakness (HP:0007340)1.87829525
119Stridor (HP:0010307)1.87728252
120Abnormality of the pulmonary veins (HP:0011718)1.86859141
121Cutaneous photosensitivity (HP:0000992)1.85181020
122Abnormality of cochlea (HP:0000375)1.84360102
123Eosinophilia (HP:0001880)1.84330972
124Congenital ichthyosiform erythroderma (HP:0007431)1.83866472
125Scanning speech (HP:0002168)1.83009481
126* Abnormality of the gallbladder (HP:0005264)1.82682245
127Increased IgM level (HP:0003496)1.81727473
128Congenital primary aphakia (HP:0007707)1.81629171
129Retrobulbar optic neuritis (HP:0100654)1.81583051
130Optic neuritis (HP:0100653)1.81583051
131Aplasia/Hypoplasia affecting the retina (HP:0008061)1.81319255
132Abnormality of T cells (HP:0002843)1.80247531
133Delusions (HP:0000746)1.79404458
134Reticulocytosis (HP:0001923)1.79097056
135Akinesia (HP:0002304)1.78745724
136Oral leukoplakia (HP:0002745)1.77383347
137Urticaria (HP:0001025)1.77329695
138Dyschromatopsia (HP:0007641)1.75886252
139Papillary thyroid carcinoma (HP:0002895)1.75727935
140Spastic tetraparesis (HP:0001285)1.75721317
141Azoospermia (HP:0000027)1.75396907
142Cerebral hemorrhage (HP:0001342)1.75176116
143Abnormality of the middle phalanges of the toes (HP:0010183)1.74354464
144Abnormality of chromosome segregation (HP:0002916)1.74170122
145Type 2 muscle fiber atrophy (HP:0003554)1.73280714
146Megalencephaly (HP:0001355)1.73253197
147Clumsiness (HP:0002312)1.73237607
148Segmental peripheral demyelination/remyelination (HP:0003481)1.72857525
149Generalized aminoaciduria (HP:0002909)1.72523162
150Generalized myoclonic seizures (HP:0002123)1.72392316
151Biliary tract neoplasm (HP:0100574)1.72373469
152Gingival bleeding (HP:0000225)1.71403815
153Increased circulating renin level (HP:0000848)1.70314041
154Hematochezia (HP:0002573)1.69655303
155Chin dimple (HP:0010751)1.69229049
156Nonprogressive disorder (HP:0003680)1.69204407
157Abnormality of macrophages (HP:0004311)1.68454805
158Atelectasis (HP:0100750)1.67937469
159Septo-optic dysplasia (HP:0100842)1.66896803
160Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.66302938
161Posterior subcapsular cataract (HP:0007787)1.66135761
162Fair hair (HP:0002286)1.66000811
163Symphalangism affecting the phalanges of the hand (HP:0009773)1.65294579
164Capillary hemangiomas (HP:0005306)1.64860993
165Facial hemangioma (HP:0000329)1.64815971
1663-Methylglutaconic aciduria (HP:0003535)1.64799536
167Abnormality of eosinophils (HP:0001879)1.64768797
168Gowers sign (HP:0003391)1.64647290
169Hypophosphatemic rickets (HP:0004912)1.64220601
170Osteomyelitis (HP:0002754)1.64180486
171Duplicated collecting system (HP:0000081)1.64146848
172Partial duplication of thumb phalanx (HP:0009944)1.64095757
173Foot dorsiflexor weakness (HP:0009027)1.60476953
174Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.57839511
175Seborrheic dermatitis (HP:0001051)1.56566753
176Prominent occiput (HP:0000269)1.56522844
177Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.56353877
178Nephrogenic diabetes insipidus (HP:0009806)1.55348081
179Decreased motor nerve conduction velocity (HP:0003431)1.53852436
180Abnormal ciliary motility (HP:0012262)1.53543481
181Bowel incontinence (HP:0002607)1.53249595
182Poor speech (HP:0002465)1.53225462

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.18553706
2EIF2AK13.88052529
3NEK13.78420026
4OXSR13.71506331
5MOS2.99762310
6BMPR22.98633127
7TAOK32.55629037
8MAPKAPK52.49397910
9EPHB12.27786723
10GRK62.22534409
11PBK2.21109881
12TRIM282.16495297
13LATS12.07486137
14PLK32.07201829
15WNK42.06048288
16PKN11.97749011
17TXK1.95755311
18BCR1.92127994
19CDK191.91495936
20IKBKE1.87845013
21PTK2B1.82211592
22MAP3K61.81304553
23MAP3K31.77304247
24PIM11.76137434
25STK241.72825523
26DYRK21.71800573
27KSR11.67562629
28MAP3K51.66986634
29WNK11.65834613
30CSNK1G31.62623580
31NUAK11.59146589
32TYRO31.52404938
33MAP4K21.52033181
34TTK1.51814119
35DYRK31.47717109
36CSNK1G11.47659138
37TAOK21.44410831
38CSNK1A1L1.43078660
39PIK3CG1.40304631
40MAP2K31.39115138
41MUSK1.34969972
42PAK61.34814123
43CSNK1G21.32650842
44MET1.32397499
45ARAF1.32207631
46KSR21.32038285
47ERBB31.31405981
48ERBB41.29662036
49MARK31.29022028
50TAOK11.27334875
51LIMK11.27150646
52STK101.26753524
53SGK4941.25507413
54SGK2231.25507413
55PNCK1.23365926
56EIF2AK31.22695807
57LATS21.19219022
58FGFR21.16017813
59ROCK21.14822686
60MST41.13902927
61CCNB11.12068088
62TESK21.11573474
63BRAF1.11564384
64GRK51.09950153
65UHMK11.09249363
66NTRK11.08441716
67SRPK11.07534060
68CAMK2B1.06392325
69VRK21.06285243
70MAP3K91.03537574
71FGR1.01954880
72PLK41.00708944
73MAPK130.98688393
74NEK60.95071277
75BLK0.92912207
76TNIK0.90468109
77MARK20.89907506
78PLK10.89348737
79TGFBR20.88041286
80MAP3K120.87859691
81PRKD30.84895381
82SGK20.84277648
83CSK0.83890710
84MAP3K40.82118842
85EPHA40.81973044
86TLK10.81225897
87CAMK2D0.81092635
88CASK0.80810129
89MELK0.80579737
90BRSK20.79738463
91NEK90.79462047
92CHEK20.79068925
93CLK10.77250155
94CAMK2A0.76566574
95BUB10.75490900
96CDK150.74421518
97DMPK0.73575317
98CDK140.71662415
99RPS6KA50.70663883
100CDK180.69845113
101MARK10.69407740
102STK38L0.68242986
103TEC0.68093598
104ICK0.66930851
105SYK0.65841942
106CDK11A0.64465925
107NTRK20.64142614
108PRKCQ0.63946103
109CAMK2G0.63618185
110PRPF4B0.62333734
111CDK120.61909582
112FES0.61847547
113TRPM70.60488415
114MAP3K130.60461034
115EGFR0.60144548
116JAK30.60017461
117PAK30.59750421
118STK40.59372020
119CDC70.58979885
120CSNK1D0.58003292
121CDK50.57624347
122STK30.57494953
123WNK30.56214567
124RAF10.55479003
125MATK0.53694903
126GRK10.50406361
127CHUK0.50101971
128DYRK1A0.49859132
129STK160.48813425
130AKT30.48730426
131PLK20.48617780
132AURKA0.48289281
133PRKD20.48078378
134CDK80.47996132
135PRKCI0.47441706
136BMPR1B0.47173584
137PAK10.45714204
138IKBKB0.45029648
139ACVR1B0.42750456
140PINK10.42307939
141PRKD10.42244015
142GRK70.41713358
143PHKG10.41372012
144PHKG20.41372012
145ERBB20.41000329
146SGK30.40822048
147CSNK1A10.38837346
148FRK0.38527397
149RIPK40.38521762
150LYN0.38481606
151MAP3K140.38458933
152VRK10.38259380
153CDK90.38196496
154ABL20.37719084
155TBK10.31984268
156IRAK30.31315132
157IRAK10.29723831

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.00405882
2Vitamin B6 metabolism_Homo sapiens_hsa007503.80312865
3Steroid biosynthesis_Homo sapiens_hsa001003.66899314
4Ether lipid metabolism_Homo sapiens_hsa005653.64925733
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.45212609
6Fatty acid elongation_Homo sapiens_hsa000623.26373086
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.96025081
8Proteasome_Homo sapiens_hsa030502.74928739
9Linoleic acid metabolism_Homo sapiens_hsa005912.50926224
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.43232142
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.39961774
12Ovarian steroidogenesis_Homo sapiens_hsa049132.17337626
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.05715171
14Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.86061491
15Protein export_Homo sapiens_hsa030601.79459703
16Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.79260363
17p53 signaling pathway_Homo sapiens_hsa041151.78109382
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.69629390
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.65088530
20Oxidative phosphorylation_Homo sapiens_hsa001901.59726542
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58698949
22Basal transcription factors_Homo sapiens_hsa030221.55494300
23Sulfur metabolism_Homo sapiens_hsa009201.54291750
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.52663792
25Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.49509048
26Mismatch repair_Homo sapiens_hsa034301.48251660
27Sphingolipid metabolism_Homo sapiens_hsa006001.48005772
28Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.44833945
29Nucleotide excision repair_Homo sapiens_hsa034201.41209079
30Legionellosis_Homo sapiens_hsa051341.40426887
31Axon guidance_Homo sapiens_hsa043601.39675507
32Serotonergic synapse_Homo sapiens_hsa047261.35824991
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.32876096
34FoxO signaling pathway_Homo sapiens_hsa040681.32120333
35Dorso-ventral axis formation_Homo sapiens_hsa043201.31236378
36Arachidonic acid metabolism_Homo sapiens_hsa005901.27569229
37Glutamatergic synapse_Homo sapiens_hsa047241.27386592
38Histidine metabolism_Homo sapiens_hsa003401.26732433
39NOD-like receptor signaling pathway_Homo sapiens_hsa046211.24368961
40Measles_Homo sapiens_hsa051621.23148957
41Long-term depression_Homo sapiens_hsa047301.21958840
42Hematopoietic cell lineage_Homo sapiens_hsa046401.21418891
43RNA transport_Homo sapiens_hsa030131.20823425
44GABAergic synapse_Homo sapiens_hsa047271.20022488
45Renal cell carcinoma_Homo sapiens_hsa052111.15632804
46Parkinsons disease_Homo sapiens_hsa050121.13462555
47Caffeine metabolism_Homo sapiens_hsa002321.12348379
48Alzheimers disease_Homo sapiens_hsa050101.10752260
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.10287894
50African trypanosomiasis_Homo sapiens_hsa051431.10020629
51Butanoate metabolism_Homo sapiens_hsa006501.09122425
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.07070471
53T cell receptor signaling pathway_Homo sapiens_hsa046601.06303611
54Non-small cell lung cancer_Homo sapiens_hsa052231.04317035
55Alcoholism_Homo sapiens_hsa050341.03824293
56Toll-like receptor signaling pathway_Homo sapiens_hsa046201.01667355
57Systemic lupus erythematosus_Homo sapiens_hsa053221.00854753
58Osteoclast differentiation_Homo sapiens_hsa043801.00152884
59Tight junction_Homo sapiens_hsa045300.99955017
60Folate biosynthesis_Homo sapiens_hsa007900.98036025
61Hepatitis B_Homo sapiens_hsa051610.97697364
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.96246150
63Base excision repair_Homo sapiens_hsa034100.96084511
64Collecting duct acid secretion_Homo sapiens_hsa049660.94075598
65TGF-beta signaling pathway_Homo sapiens_hsa043500.93228059
66Arginine and proline metabolism_Homo sapiens_hsa003300.93093227
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.92940590
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91719681
69Oocyte meiosis_Homo sapiens_hsa041140.91408831
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91001910
71Chemokine signaling pathway_Homo sapiens_hsa040620.90306820
72Apoptosis_Homo sapiens_hsa042100.89285199
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.88368399
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.87260875
75Huntingtons disease_Homo sapiens_hsa050160.83954906
76Glutathione metabolism_Homo sapiens_hsa004800.83323785
77Morphine addiction_Homo sapiens_hsa050320.83096526
78Ras signaling pathway_Homo sapiens_hsa040140.83073128
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.81172072
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.80127911
81Non-homologous end-joining_Homo sapiens_hsa034500.79319113
82Choline metabolism in cancer_Homo sapiens_hsa052310.76818348
83TNF signaling pathway_Homo sapiens_hsa046680.76146573
84Fanconi anemia pathway_Homo sapiens_hsa034600.75436500
85Herpes simplex infection_Homo sapiens_hsa051680.74571787
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74189119
87Phagosome_Homo sapiens_hsa041450.73781457
88RNA degradation_Homo sapiens_hsa030180.73134554
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.72821088
90Influenza A_Homo sapiens_hsa051640.71840700
91Cardiac muscle contraction_Homo sapiens_hsa042600.71725674
92HIF-1 signaling pathway_Homo sapiens_hsa040660.70643056
93Small cell lung cancer_Homo sapiens_hsa052220.70638415
94Thyroid cancer_Homo sapiens_hsa052160.70290950
95Homologous recombination_Homo sapiens_hsa034400.68605002
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68569188
97Rheumatoid arthritis_Homo sapiens_hsa053230.68158916
98Tuberculosis_Homo sapiens_hsa051520.66222345
99Epstein-Barr virus infection_Homo sapiens_hsa051690.64519892
100Cell cycle_Homo sapiens_hsa041100.63711439
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62818358
102Inositol phosphate metabolism_Homo sapiens_hsa005620.61193737
103Viral carcinogenesis_Homo sapiens_hsa052030.60855571
104Shigellosis_Homo sapiens_hsa051310.60771109
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60613752
106Phototransduction_Homo sapiens_hsa047440.60468978
107Primary immunodeficiency_Homo sapiens_hsa053400.60055600
108RNA polymerase_Homo sapiens_hsa030200.58995332
109Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58485430
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57843964
111MicroRNAs in cancer_Homo sapiens_hsa052060.57580530
112Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57106447
113Endometrial cancer_Homo sapiens_hsa052130.55726190
114Dopaminergic synapse_Homo sapiens_hsa047280.55363588
115Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54996134
116Cocaine addiction_Homo sapiens_hsa050300.54666067
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52667935
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52292826
119Nicotine addiction_Homo sapiens_hsa050330.51212242
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51040920
121B cell receptor signaling pathway_Homo sapiens_hsa046620.50959562
122Hedgehog signaling pathway_Homo sapiens_hsa043400.50296495
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50219012
124HTLV-I infection_Homo sapiens_hsa051660.50182051
125Pyruvate metabolism_Homo sapiens_hsa006200.50020212
126GnRH signaling pathway_Homo sapiens_hsa049120.49963107
127* Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49941132
128ErbB signaling pathway_Homo sapiens_hsa040120.49862203
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.49295019
130Gap junction_Homo sapiens_hsa045400.49261419
131mRNA surveillance pathway_Homo sapiens_hsa030150.48888273
132Cysteine and methionine metabolism_Homo sapiens_hsa002700.48594064
133Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48446449
134Circadian rhythm_Homo sapiens_hsa047100.48443265
135Pancreatic cancer_Homo sapiens_hsa052120.48272987
136Salivary secretion_Homo sapiens_hsa049700.47661989
137Circadian entrainment_Homo sapiens_hsa047130.47365957
138Regulation of autophagy_Homo sapiens_hsa041400.47345343
139Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47155425
140Cholinergic synapse_Homo sapiens_hsa047250.46234677
141Vibrio cholerae infection_Homo sapiens_hsa051100.45700874
142Endocytosis_Homo sapiens_hsa041440.45572820
143Spliceosome_Homo sapiens_hsa030400.45539801
144Mineral absorption_Homo sapiens_hsa049780.45319458
145Salmonella infection_Homo sapiens_hsa051320.43465124
146Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42702102
147Taste transduction_Homo sapiens_hsa047420.42528181
148Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41780020
149Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41455119
150* Metabolic pathways_Homo sapiens_hsa011000.40607141
151Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39090263
152Gastric acid secretion_Homo sapiens_hsa049710.38730828
153Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38577821
154Propanoate metabolism_Homo sapiens_hsa006400.38067470
155Nitrogen metabolism_Homo sapiens_hsa009100.37782355
156Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37447199
157Olfactory transduction_Homo sapiens_hsa047400.36943292
158Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36072799
159Steroid hormone biosynthesis_Homo sapiens_hsa001400.35723182
160cAMP signaling pathway_Homo sapiens_hsa040240.35049355
161Leishmaniasis_Homo sapiens_hsa051400.34840295
162Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.33227043
163Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32837995
164Hippo signaling pathway_Homo sapiens_hsa043900.32069549
165Malaria_Homo sapiens_hsa051440.30685507
166MAPK signaling pathway_Homo sapiens_hsa040100.30426035
167Oxytocin signaling pathway_Homo sapiens_hsa049210.30271460

Most similar genes based on co-expression Upload to Enrichr

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