BPHL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the serine protease family of hydrolytic enzymes which contain a serine in their active site. The encoded protein may play a role in activation of the antiviral prodrug valacyclovir. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.37526065
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.37526065
3L-phenylalanine metabolic process (GO:0006558)7.07426426
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.07426426
5aromatic amino acid family catabolic process (GO:0009074)6.73981677
6tryptophan catabolic process (GO:0006569)6.14294507
7indole-containing compound catabolic process (GO:0042436)6.14294507
8indolalkylamine catabolic process (GO:0046218)6.14294507
9glyoxylate metabolic process (GO:0046487)6.13022765
10tryptophan metabolic process (GO:0006568)5.81021910
11kynurenine metabolic process (GO:0070189)5.80219071
12cysteine metabolic process (GO:0006534)5.75588432
13bile acid biosynthetic process (GO:0006699)5.63817867
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.51321702
15sulfur amino acid catabolic process (GO:0000098)5.33440059
16lysine catabolic process (GO:0006554)5.26266841
17lysine metabolic process (GO:0006553)5.26266841
18alpha-linolenic acid metabolic process (GO:0036109)5.22655519
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.10670356
20serine family amino acid catabolic process (GO:0009071)5.05780814
21urea metabolic process (GO:0019627)5.00691928
22urea cycle (GO:0000050)5.00691928
23cellular ketone body metabolic process (GO:0046950)4.94070006
24aromatic amino acid family metabolic process (GO:0009072)4.88332283
25high-density lipoprotein particle remodeling (GO:0034375)4.87961202
26amino-acid betaine metabolic process (GO:0006577)4.83011236
27negative regulation of fibrinolysis (GO:0051918)4.81743413
28bile acid metabolic process (GO:0008206)4.74194935
29homocysteine metabolic process (GO:0050667)4.72646979
30protein carboxylation (GO:0018214)4.66765852
31peptidyl-glutamic acid carboxylation (GO:0017187)4.66765852
32nitrogen cycle metabolic process (GO:0071941)4.65879792
33alpha-amino acid catabolic process (GO:1901606)4.64495427
34regulation of fibrinolysis (GO:0051917)4.64422702
35tyrosine metabolic process (GO:0006570)4.52707921
36complement activation, alternative pathway (GO:0006957)4.51286617
37regulation of protein activation cascade (GO:2000257)4.48696807
38indolalkylamine metabolic process (GO:0006586)4.36107228
39cellular amino acid catabolic process (GO:0009063)4.35603744
40drug transmembrane transport (GO:0006855)4.35067271
41amine catabolic process (GO:0009310)4.32384065
42cellular biogenic amine catabolic process (GO:0042402)4.32384065
43regulation of cholesterol esterification (GO:0010872)4.31321304
44serine family amino acid metabolic process (GO:0009069)4.29104279
45urate metabolic process (GO:0046415)4.28672375
46cellular glucuronidation (GO:0052695)4.28052109
47ketone body metabolic process (GO:1902224)4.27777838
48glutamate metabolic process (GO:0006536)4.27558499
49reverse cholesterol transport (GO:0043691)4.27514602
50regulation of triglyceride catabolic process (GO:0010896)4.27099258
51benzene-containing compound metabolic process (GO:0042537)4.25068701
52drug catabolic process (GO:0042737)4.24534074
53plasma lipoprotein particle remodeling (GO:0034369)4.22564639
54protein-lipid complex remodeling (GO:0034368)4.22564639
55macromolecular complex remodeling (GO:0034367)4.22564639
56short-chain fatty acid metabolic process (GO:0046459)4.20843389
57acylglycerol homeostasis (GO:0055090)4.19127710
58triglyceride homeostasis (GO:0070328)4.19127710
59regulation of complement activation (GO:0030449)4.18114166
60aldehyde catabolic process (GO:0046185)4.14641563
61behavioral response to nicotine (GO:0035095)4.13444568
62coenzyme catabolic process (GO:0009109)4.12561526
63cellular modified amino acid catabolic process (GO:0042219)4.11290864
64negative regulation of sterol transport (GO:0032372)4.10070934
65negative regulation of cholesterol transport (GO:0032375)4.10070934
66serine family amino acid biosynthetic process (GO:0009070)4.05991190
67glycine metabolic process (GO:0006544)4.03180817
68imidazole-containing compound metabolic process (GO:0052803)3.98585716
69ethanol oxidation (GO:0006069)3.98422143
70phospholipid efflux (GO:0033700)3.96993057
71bile acid and bile salt transport (GO:0015721)3.95868622
72glucuronate metabolic process (GO:0019585)3.94708071
73uronic acid metabolic process (GO:0006063)3.94708071
74organic acid catabolic process (GO:0016054)3.92380634
75carboxylic acid catabolic process (GO:0046395)3.92380634
76aspartate family amino acid catabolic process (GO:0009068)3.87616650
77fatty acid beta-oxidation (GO:0006635)3.85873442
78fatty acid oxidation (GO:0019395)3.81968998
792-oxoglutarate metabolic process (GO:0006103)3.79679629
80carnitine metabolic process (GO:0009437)3.79496480
81dicarboxylic acid biosynthetic process (GO:0043650)3.79425463
82lipid oxidation (GO:0034440)3.74745534
83monocarboxylic acid catabolic process (GO:0072329)3.74693545
84plasma lipoprotein particle clearance (GO:0034381)3.73337131
85exogenous drug catabolic process (GO:0042738)3.72978737
86low-density lipoprotein particle remodeling (GO:0034374)3.72730317
87acetyl-CoA metabolic process (GO:0006084)3.70908071
88pyrimidine nucleobase catabolic process (GO:0006208)3.70316625
89flavonoid metabolic process (GO:0009812)3.69406067
90response to nitrosative stress (GO:0051409)3.69053786
91valine metabolic process (GO:0006573)3.67658153
92drug transport (GO:0015893)3.66053167
93fatty acid catabolic process (GO:0009062)3.64524980
94arginine metabolic process (GO:0006525)3.63426253
95cholesterol efflux (GO:0033344)3.56961337
96establishment of protein localization to mitochondrial membrane (GO:0090151)3.55434314
97chaperone-mediated protein transport (GO:0072321)3.55003481
98cofactor catabolic process (GO:0051187)3.54180415
99drug metabolic process (GO:0017144)3.52916369
100water-soluble vitamin biosynthetic process (GO:0042364)3.50595852
101nicotinamide nucleotide biosynthetic process (GO:0019359)3.48043536
102pyridine nucleotide biosynthetic process (GO:0019363)3.48043536
103branched-chain amino acid catabolic process (GO:0009083)3.48024519
104NAD biosynthetic process (GO:0009435)3.47052360
105fibrinolysis (GO:0042730)3.46546810
106mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.41303909
107ATP synthesis coupled proton transport (GO:0015986)3.40127857
108energy coupled proton transport, down electrochemical gradient (GO:0015985)3.40127857
109mitochondrial respiratory chain complex I assembly (GO:0032981)3.31490216
110NADH dehydrogenase complex assembly (GO:0010257)3.31490216
111mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.31490216
112protein complex biogenesis (GO:0070271)3.30713562
113epithelial cilium movement (GO:0003351)3.24352241
114mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.18099111
115mitochondrial respiratory chain complex assembly (GO:0033108)3.17287110
116intraciliary transport (GO:0042073)3.17125350
117nucleobase catabolic process (GO:0046113)3.16858586
118nonmotile primary cilium assembly (GO:0035058)3.03104196
119regulation of cilium movement (GO:0003352)2.90184797
120oxidative demethylation (GO:0070989)2.83411533
121epoxygenase P450 pathway (GO:0019373)2.81056428
122epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.80820538
123electron transport chain (GO:0022900)2.72272386
124cilium movement (GO:0003341)2.71007247
125respiratory electron transport chain (GO:0022904)2.70411684
126ubiquinone metabolic process (GO:0006743)2.65442409
127L-serine metabolic process (GO:0006563)2.62573148
128quinone biosynthetic process (GO:1901663)2.59925363
129ubiquinone biosynthetic process (GO:0006744)2.58564278
130short-term memory (GO:0007614)2.54610745
131platelet dense granule organization (GO:0060155)2.50656326
132negative regulation of transcription regulatory region DNA binding (GO:2000678)2.50624251
133axoneme assembly (GO:0035082)2.48929787
134omega-hydroxylase P450 pathway (GO:0097267)2.47281028
135respiratory chain complex IV assembly (GO:0008535)2.46236535
136RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.45517865
137tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.45517865
138protein polyglutamylation (GO:0018095)2.44238672
139limb bud formation (GO:0060174)2.42740729
140ribosomal small subunit assembly (GO:0000028)2.40757863
141protein neddylation (GO:0045116)2.39545818
142detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.37445759
143phenylpropanoid metabolic process (GO:0009698)2.34632443
144vitamin biosynthetic process (GO:0009110)2.33937901
145quinone metabolic process (GO:1901661)2.33225373
146DNA damage response, detection of DNA damage (GO:0042769)2.32760989
147somite development (GO:0061053)2.31673245
148axonemal dynein complex assembly (GO:0070286)2.30455912
149cilium organization (GO:0044782)2.30422016
150cholesterol biosynthetic process (GO:0006695)2.29896923
151amino acid salvage (GO:0043102)2.29184901
152L-methionine salvage (GO:0071267)2.29184901
153L-methionine biosynthetic process (GO:0071265)2.29184901
154arginine catabolic process (GO:0006527)2.28945184
155cilium assembly (GO:0042384)2.28257490
156regulation of hexokinase activity (GO:1903299)2.27530390
157regulation of glucokinase activity (GO:0033131)2.27530390
158cilium morphogenesis (GO:0060271)2.27005289
159kidney morphogenesis (GO:0060993)2.26579821
160retinal ganglion cell axon guidance (GO:0031290)2.23931272
161cell proliferation in forebrain (GO:0021846)2.23010661
162protein localization to cilium (GO:0061512)2.22238871
163S-adenosylmethionine metabolic process (GO:0046500)2.21267549
164sulfation (GO:0051923)2.21142299
165regulation of mitochondrial translation (GO:0070129)2.19995244

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.10464532
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.92757845
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.66136524
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.18854728
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.31145577
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.99177029
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.88646083
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.09944334
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.68701270
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.29101788
11ZNF274_21170338_ChIP-Seq_K562_Hela3.11571118
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.88698599
13EZH2_22144423_ChIP-Seq_EOC_Human2.80615777
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.71054995
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.55854788
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.54496461
17IGF1R_20145208_ChIP-Seq_DFB_Human2.48107474
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.46665984
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.34275471
20VDR_22108803_ChIP-Seq_LS180_Human2.29550808
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.25246773
22GBX2_23144817_ChIP-Seq_PC3_Human2.14970282
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.12456204
24TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.09096233
25* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.3860275
26FUS_26573619_Chip-Seq_HEK293_Human1.95408979
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93960918
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81359390
29GATA1_22025678_ChIP-Seq_K562_Human1.78554833
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74346161
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74168038
32P300_19829295_ChIP-Seq_ESCs_Human1.72335992
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68822627
34EWS_26573619_Chip-Seq_HEK293_Human1.67225851
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64758107
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.62202383
37CLOCK_20551151_ChIP-Seq_293T_Human1.56142820
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.55965414
39JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.53423943
40RBPJ_22232070_ChIP-Seq_NCS_Mouse1.51249457
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.45614381
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44936878
43MYC_18940864_ChIP-ChIP_HL60_Human1.43858654
44STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.40935319
45* FOXA2_19822575_ChIP-Seq_HepG2_Human1.40439532
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38484324
47GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.36621169
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34774243
49* HNF4A_19822575_ChIP-Seq_HepG2_Human1.34294493
50HTT_18923047_ChIP-ChIP_STHdh_Human1.33461411
51POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31697246
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30125693
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28232511
54ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.28162861
55ER_23166858_ChIP-Seq_MCF-7_Human1.28018609
56ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.26537598
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.25822372
58ELK1_19687146_ChIP-ChIP_HELA_Human1.25392564
59CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.23233281
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22480603
61KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21889885
62RNF2_27304074_Chip-Seq_NSC_Mouse1.21140784
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20386890
64TP53_22573176_ChIP-Seq_HFKS_Human1.18063309
65REST_21632747_ChIP-Seq_MESCs_Mouse1.15945136
66IRF8_22096565_ChIP-ChIP_GC-B_Human1.13929379
67ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13732171
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12787964
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12282935
70RARG_19884340_ChIP-ChIP_MEFs_Mouse1.11993732
71ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11834672
72RXRA_24833708_ChIP-Seq_LIVER_Mouse1.11431700
73* SOX2_19829295_ChIP-Seq_ESCs_Human1.10386177
74* NANOG_19829295_ChIP-Seq_ESCs_Human1.10386177
75CBP_20019798_ChIP-Seq_JUKART_Human1.10075471
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10075471
77TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.09202317
78AR_25329375_ChIP-Seq_VCAP_Human1.08673072
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08024227
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08024227
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07428645
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.05422305
83TCF4_22108803_ChIP-Seq_LS180_Human1.04937175
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04904889
85PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.04433617
86PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04329792
87* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04117537
88FOXA1_25329375_ChIP-Seq_VCAP_Human1.02864079
89FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02864079
90SMAD4_21799915_ChIP-Seq_A2780_Human1.02235088
91SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01905258
92CREB1_15753290_ChIP-ChIP_HEK293T_Human1.01715088
93SOX2_16153702_ChIP-ChIP_HESCs_Human1.01378686
94EZH2_27304074_Chip-Seq_ESCs_Mouse1.00783597
95PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00653787
96NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.99912919
97THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99335482
98CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98949363
99FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96770528
100STAT3_23295773_ChIP-Seq_U87_Human0.95935418
101* CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.95681137
102VDR_23849224_ChIP-Seq_CD4+_Human0.95422618
103SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95392350
104NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94915893
105GATA4_25053715_ChIP-Seq_YYC3_Human0.94588753
106* GATA3_21878914_ChIP-Seq_MCF-7_Human0.94177530
107RUNX2_22187159_ChIP-Seq_PCA_Human0.93673986
108MYC_19829295_ChIP-Seq_ESCs_Human0.91553694
109NANOG_16153702_ChIP-ChIP_HESCs_Human0.91204811
110SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90368344
111CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90052051
112PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88650765
113* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.87853107
114EED_16625203_ChIP-ChIP_MESCs_Mouse0.87707406
115SMAD4_21741376_ChIP-Seq_EPCs_Human0.86367234
116KAP1_22055183_ChIP-Seq_ESCs_Mouse0.86099959
117* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84127460
118RAD21_21589869_ChIP-Seq_MESCs_Mouse0.77114559
119BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.76684370
120AR_20517297_ChIP-Seq_VCAP_Human0.76554741
121ESR1_15608294_ChIP-ChIP_MCF-7_Human0.76528407
122NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.73956631
123BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.73589981
124NRF2_20460467_ChIP-Seq_MEFs_Mouse0.73149880
125NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.73149880
126SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.72373493
127PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.71604120
128ESR1_21235772_ChIP-Seq_MCF-7_Human0.70453624
129AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.69275600
130FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.68284956
131Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.65966530
132CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.64727403
133ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.63896887
134RARA_24833708_ChIP-Seq_LIVER_Mouse0.63658657
135FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.62214801
136SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.61723150
137EGR1_19032775_ChIP-ChIP_M12_Human0.60877848
138ESR2_21235772_ChIP-Seq_MCF-7_Human0.60730836
139CEBPB_22108803_ChIP-Seq_LS180_Human0.60678158
140PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.60468435
141NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.60453737
142CDX2_20551321_ChIP-Seq_CACO-2_Human0.60196502
143PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.59816385
144STAT1_17558387_ChIP-Seq_HELA_Human0.59579592
145TAF15_26573619_Chip-Seq_HEK293_Human0.58893818
146RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.58738709
147RARB_24833708_ChIP-Seq_LIVER_Mouse0.57876774
148SALL4_18804426_ChIP-ChIP_XEN_Mouse0.56490961
149ERG_20517297_ChIP-Seq_VCAP_Human0.55569190
150TAF2_19829295_ChIP-Seq_ESCs_Human0.54813320
151FOXA1_25552417_ChIP-Seq_VCAP_Human0.53856917
152MYC_19915707_ChIP-ChIP_AK7_Human0.52895027
153ZNF263_19887448_ChIP-Seq_K562_Human0.52423425
154BCAT_22108803_ChIP-Seq_LS180_Human0.51669319
155SOX2_20726797_ChIP-Seq_SW620_Human0.50628219
156SRF_21415370_ChIP-Seq_HL-1_Mouse0.50465886
157CBP_21632823_ChIP-Seq_H3396_Human0.50417701
158STAT3_1855785_ChIP-Seq_MESCs_Mouse0.50369041
159ESET_19884257_ChIP-Seq_ESCs_Mouse0.49947147
160LXR_22292898_ChIP-Seq_THP-1_Human0.49779546
161SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.49682794
162GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.49469326
163P53_21459846_ChIP-Seq_SAOS-2_Human0.49367110
164SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.48435556
165PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.48304497
166STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.47941202
167ESR1_20079471_ChIP-ChIP_T-47D_Human0.47534385
168CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.47410241
169PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.45250153
170* SOX2_22085726_ChIP-Seq_NPCs_Mouse0.45214860
171LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.44054669
172FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.43416734
173EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.43269520
174FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.43096247
175NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.41878071
176FOXH1_21741376_ChIP-Seq_EPCs_Human0.41789647
177SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.41157999
178SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.40940712
179IRF1_19129219_ChIP-ChIP_H3396_Human0.40863916
180PIAS1_25552417_ChIP-Seq_VCAP_Human0.40764645
181NCOR_22424771_ChIP-Seq_293T_Human0.40721508
182GATA1_19941827_ChIP-Seq_MEL_Mouse0.40057374
183GATA2_19941826_ChIP-Seq_K562_Human0.39772390
184CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.39612903

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.24963461
2MP0005360_urolithiasis7.66957189
3MP0005085_abnormal_gallbladder_physiolo5.99860922
4MP0005365_abnormal_bile_salt5.97610635
5MP0008875_abnormal_xenobiotic_pharmacok5.12152960
6MP0003806_abnormal_nucleotide_metabolis4.16182941
7MP0003252_abnormal_bile_duct3.71688354
8MP0010329_abnormal_lipoprotein_level3.33457269
9MP0005332_abnormal_amino_acid3.23142963
10MP0003195_calcinosis3.21071906
11MP0005083_abnormal_biliary_tract2.78016692
12MP0003136_yellow_coat_color2.69343842
13MP0006292_abnormal_olfactory_placode2.67075650
14MP0009840_abnormal_foam_cell2.63187285
15MP0004019_abnormal_vitamin_homeostasis2.55278838
16MP0001666_abnormal_nutrient_absorption2.49845936
17MP0003191_abnormal_cellular_cholesterol2.45318351
18MP0002138_abnormal_hepatobiliary_system2.12523954
19MP0002938_white_spotting2.10218507
20MP0001529_abnormal_vocalization2.06503145
21MP0002118_abnormal_lipid_homeostasis2.00632378
22MP0000609_abnormal_liver_physiology1.96082346
23MP0003880_abnormal_central_pattern1.93572064
24MP0008789_abnormal_olfactory_epithelium1.92567147
25MP0005319_abnormal_enzyme/_coenzyme1.88633796
26MP0002102_abnormal_ear_morphology1.86919682
27MP0002653_abnormal_ependyma_morphology1.85893549
28MP0005551_abnormal_eye_electrophysiolog1.83214867
29MP0002638_abnormal_pupillary_reflex1.81515935
30MP0001764_abnormal_homeostasis1.81463585
31MP0009643_abnormal_urine_homeostasis1.78820166
32MP0000566_synostosis1.72781726
33MP0003186_abnormal_redox_activity1.69821049
34MP0005584_abnormal_enzyme/coenzyme_acti1.67931313
35MP0008877_abnormal_DNA_methylation1.66719926
36MP0003122_maternal_imprinting1.64281516
37MP0003868_abnormal_feces_composition1.58824921
38MP0005499_abnormal_olfactory_system1.57490921
39MP0005394_taste/olfaction_phenotype1.57490921
40MP0006072_abnormal_retinal_apoptosis1.56069240
41MP0009697_abnormal_copulation1.55379880
42MP0003123_paternal_imprinting1.54601758
43MP0004133_heterotaxia1.54086015
44MP0001293_anophthalmia1.52945917
45MP0003787_abnormal_imprinting1.52861391
46MP0006276_abnormal_autonomic_nervous1.50898270
47MP0003890_abnormal_embryonic-extraembry1.46364062
48MP0005636_abnormal_mineral_homeostasis1.44807866
49MP0003121_genomic_imprinting1.42987346
50MP0002160_abnormal_reproductive_system1.40503674
51MP0003646_muscle_fatigue1.39750306
52MP0000778_abnormal_nervous_system1.39481744
53MP0010030_abnormal_orbit_morphology1.39121001
54MP0005451_abnormal_body_composition1.38473838
55MP0000372_irregular_coat_pigmentation1.35497619
56MP0005253_abnormal_eye_physiology1.34418714
57MP0002234_abnormal_pharynx_morphology1.25970785
58MP0002736_abnormal_nociception_after1.25332516
59MP0002876_abnormal_thyroid_physiology1.24506462
60MP0001485_abnormal_pinna_reflex1.24325848
61MP0004043_abnormal_pH_regulation1.22789471
62MP0000631_abnormal_neuroendocrine_gland1.22653388
63MP0004142_abnormal_muscle_tone1.20040994
64MP0009046_muscle_twitch1.19069106
65MP0006036_abnormal_mitochondrial_physio1.17818478
66MP0003011_delayed_dark_adaptation1.15903745
67MP0005084_abnormal_gallbladder_morpholo1.14906065
68MP0002233_abnormal_nose_morphology1.14822748
69MP0003119_abnormal_digestive_system1.14618430
70MP0001905_abnormal_dopamine_level1.10231068
71MP0002557_abnormal_social/conspecific_i1.09876226
72MP0001968_abnormal_touch/_nociception1.09867101
73MP0005647_abnormal_sex_gland1.09109689
74MP0003937_abnormal_limbs/digits/tail_de1.08439904
75MP0005195_abnormal_posterior_eye1.07972357
76MP0002163_abnormal_gland_morphology1.07743007
77MP0000598_abnormal_liver_morphology1.06436374
78MP0001756_abnormal_urination1.06135238
79MP0002272_abnormal_nervous_system1.05299395
80MP0005646_abnormal_pituitary_gland1.05213788
81MP0003315_abnormal_perineum_morphology1.04113741
82MP0003656_abnormal_erythrocyte_physiolo1.02612441
83MP0009764_decreased_sensitivity_to1.01624913
84MP0005377_hearing/vestibular/ear_phenot1.00547091
85MP0003878_abnormal_ear_physiology1.00547091
86MP0009745_abnormal_behavioral_response0.99834938
87MP0000049_abnormal_middle_ear0.98574066
88MP0005408_hypopigmentation0.97899694
89MP0002909_abnormal_adrenal_gland0.96848164
90MP0000026_abnormal_inner_ear0.93827719
91MP0001324_abnormal_eye_pigmentation0.92865796
92MP0008058_abnormal_DNA_repair0.92633428
93MP0005187_abnormal_penis_morphology0.92486595
94MP0009642_abnormal_blood_homeostasis0.92386967
95MP0002752_abnormal_somatic_nervous0.92235080
96MP0000604_amyloidosis0.92033033
97MP0008469_abnormal_protein_level0.91997052
98MP0004145_abnormal_muscle_electrophysio0.91166294
99MP0002734_abnormal_mechanical_nocicepti0.90621433
100MP0005220_abnormal_exocrine_pancreas0.89468232
101MP0002254_reproductive_system_inflammat0.89357696
102MP0002751_abnormal_autonomic_nervous0.89204200
103MP0001286_abnormal_eye_development0.88929880
104MP0005391_vision/eye_phenotype0.88800202
105MP0009763_increased_sensitivity_to0.88480073
106MP0003938_abnormal_ear_development0.88345134
107MP0005379_endocrine/exocrine_gland_phen0.88010349
108MP0005645_abnormal_hypothalamus_physiol0.87305186
109MP0001486_abnormal_startle_reflex0.87300815
110MP0003567_abnormal_fetal_cardiomyocyte0.87285482
111MP0002078_abnormal_glucose_homeostasis0.86491465
112MP0005389_reproductive_system_phenotype0.86461849
113MP0002282_abnormal_trachea_morphology0.84777197
114MP0005535_abnormal_body_temperature0.83801341
115MP0001986_abnormal_taste_sensitivity0.83428665
116MP0002136_abnormal_kidney_physiology0.83274175
117MP0002572_abnormal_emotion/affect_behav0.82454551
118MP0000647_abnormal_sebaceous_gland0.80624393
119MP0002184_abnormal_innervation0.80604005
120MP0005376_homeostasis/metabolism_phenot0.80298936
121MP0001765_abnormal_ion_homeostasis0.80012517
122MP0002928_abnormal_bile_duct0.79478856
123MP0005670_abnormal_white_adipose0.78742642
124MP0009765_abnormal_xenobiotic_induced0.71489643
125MP0004782_abnormal_surfactant_physiolog0.69196256
126MP0002971_abnormal_brown_adipose0.66314840
127MP0002837_dystrophic_cardiac_calcinosis0.66309220
128MP0006035_abnormal_mitochondrial_morpho0.64754216
129MP0003329_amyloid_beta_deposits0.64024130
130MP0005266_abnormal_metabolism0.63172806
131MP0005334_abnormal_fat_pad0.62256250
132MP0003638_abnormal_response/metabolism_0.61755531
133MP0010368_abnormal_lymphatic_system0.60591328
134MP0004130_abnormal_muscle_cell0.58900201
135MP0001661_extended_life_span0.58191059
136MP0000230_abnormal_systemic_arterial0.54917489
137MP0003724_increased_susceptibility_to0.54108509
138MP0003953_abnormal_hormone_level0.49402145
139MP0003690_abnormal_glial_cell0.48941075
140MP0003705_abnormal_hypodermis_morpholog0.48384268
141MP0005448_abnormal_energy_balance0.47950904
142MP0000639_abnormal_adrenal_gland0.47504982
143MP0005395_other_phenotype0.47296707
144MP0000538_abnormal_urinary_bladder0.45481522
145MP0003075_altered_response_to0.44825863
146MP0008872_abnormal_physiological_respon0.44538470
147MP0008874_decreased_physiological_sensi0.44480865
148MP0005058_abnormal_lysosome_morphology0.43837269
149MP0005464_abnormal_platelet_physiology0.42705452
150MP0001853_heart_inflammation0.41233734
151MP0009053_abnormal_anal_canal0.40050649
152MP0002822_catalepsy0.38770094
153MP0002168_other_aberrant_phenotype0.38114526
154MP0008873_increased_physiological_sensi0.36996016
155MP0003718_maternal_effect0.36376874
156MP0002135_abnormal_kidney_morphology0.35952199
157MP0005166_decreased_susceptibility_to0.34382215
158MP0003959_abnormal_lean_body0.34022750
159MP0001944_abnormal_pancreas_morphology0.33349016
160MP0001845_abnormal_inflammatory_respons0.32867486
161MP0004264_abnormal_extraembryonic_tissu0.31010245
162MP0004147_increased_porphyrin_level0.28367682
163MP0009115_abnormal_fat_cell0.27915462
164MP0003436_decreased_susceptibility_to0.27169952
165MP0004381_abnormal_hair_follicle0.26890398
166MP0005666_abnormal_adipose_tissue0.26618430
167MP0001984_abnormal_olfaction0.26560021
168MP0005595_abnormal_vascular_smooth0.26027762
169MP0000249_abnormal_blood_vessel0.25268667
170MP0009379_abnormal_foot_pigmentation0.24906256
171MP0002970_abnormal_white_adipose0.23408234
172MP0002796_impaired_skin_barrier0.23375936

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.98458791
2Intrahepatic cholestasis (HP:0001406)6.35150035
3Deep venous thrombosis (HP:0002625)6.06567951
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.84312030
5Prolonged partial thromboplastin time (HP:0003645)5.62034857
6Xanthomatosis (HP:0000991)5.48261447
7Hypobetalipoproteinemia (HP:0003563)5.42435002
8Hyperlipoproteinemia (HP:0010980)4.77147897
9Hyperglycinuria (HP:0003108)4.72569984
10Hyperammonemia (HP:0001987)4.63852170
11Ketosis (HP:0001946)4.63773735
12Abnormality of glutamine family amino acid metabolism (HP:0010902)4.50106109
13Abnormality of glycine metabolism (HP:0010895)4.43197558
14Abnormality of serine family amino acid metabolism (HP:0010894)4.43197558
15Hyperglycinemia (HP:0002154)4.42277817
16Joint hemorrhage (HP:0005261)4.24819274
17Complement deficiency (HP:0004431)4.24676391
18Abnormality of aspartate family amino acid metabolism (HP:0010899)4.14342268
19Hypolipoproteinemia (HP:0010981)4.00112727
20Hypoglycemic coma (HP:0001325)3.99654358
21Abnormality of sulfur amino acid metabolism (HP:0004339)3.97729392
22Abnormality of fatty-acid metabolism (HP:0004359)3.90431327
23Ketoacidosis (HP:0001993)3.86255832
24Abnormality of the common coagulation pathway (HP:0010990)3.81200718
25Fat malabsorption (HP:0002630)3.75779395
26Abnormality of methionine metabolism (HP:0010901)3.74451142
27Gout (HP:0001997)3.69165461
28Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.66776286
29Epidermoid cyst (HP:0200040)3.62464278
30Conjugated hyperbilirubinemia (HP:0002908)3.50905648
31Delayed CNS myelination (HP:0002188)3.46347506
32Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.44377783
33Abnormality of the intrinsic pathway (HP:0010989)3.44368595
34Hypoalphalipoproteinemia (HP:0003233)3.43973128
35Pancreatic fibrosis (HP:0100732)3.42036465
36Pancreatic cysts (HP:0001737)3.39937928
37Abnormality of pyrimidine metabolism (HP:0004353)3.38477869
38Molar tooth sign on MRI (HP:0002419)3.37180930
39Abnormality of midbrain morphology (HP:0002418)3.37180930
40Abnormality of nucleobase metabolism (HP:0010932)3.35177743
41Abnormality of purine metabolism (HP:0004352)3.33527681
42True hermaphroditism (HP:0010459)3.33210858
43Hyperbilirubinemia (HP:0002904)3.22745903
44Metabolic acidosis (HP:0001942)3.21145542
45Nephronophthisis (HP:0000090)3.19481958
46Dicarboxylic aciduria (HP:0003215)3.18851136
47Abnormality of dicarboxylic acid metabolism (HP:0010995)3.18851136
48Acute necrotizing encephalopathy (HP:0006965)3.13586229
49Medial flaring of the eyebrow (HP:0010747)3.11471979
50Generalized aminoaciduria (HP:0002909)3.10279213
51Abnormality of serum amino acid levels (HP:0003112)3.07466386
52Lethargy (HP:0001254)2.99005266
53Hypercholesterolemia (HP:0003124)2.98181944
54Abnormality of complement system (HP:0005339)2.97017304
55Steatorrhea (HP:0002570)2.88177049
56Cerebral edema (HP:0002181)2.88121692
57Mitochondrial inheritance (HP:0001427)2.82042311
58Proximal tubulopathy (HP:0000114)2.80527364
59Hepatocellular carcinoma (HP:0001402)2.76674282
60Gait imbalance (HP:0002141)2.75433266
61Alkalosis (HP:0001948)2.73564362
62Abnormal mitochondria in muscle tissue (HP:0008316)2.72400075
63Vascular calcification (HP:0004934)2.68875470
64Congenital primary aphakia (HP:0007707)2.66497865
65Increased CSF lactate (HP:0002490)2.63102975
66Abnormality of the renal medulla (HP:0100957)2.62426865
67Progressive macrocephaly (HP:0004481)2.57250342
68Glycosuria (HP:0003076)2.56326129
69Abnormality of urine glucose concentration (HP:0011016)2.56326129
70Increased purine levels (HP:0004368)2.55731391
71Hyperuricemia (HP:0002149)2.55731391
72Hepatocellular necrosis (HP:0001404)2.55303392
73Vomiting (HP:0002013)2.54589719
74Colon cancer (HP:0003003)2.52986293
75Spontaneous abortion (HP:0005268)2.52942620
76Nephrogenic diabetes insipidus (HP:0009806)2.52813955
77Lipid accumulation in hepatocytes (HP:0006561)2.50876444
78Enlarged kidneys (HP:0000105)2.45559039
79Hypoglycemic seizures (HP:0002173)2.43193908
80Vaginal atresia (HP:0000148)2.39223880
81Malnutrition (HP:0004395)2.37537571
82Genital tract atresia (HP:0001827)2.37282995
83Abnormality of the labia minora (HP:0012880)2.36705597
84Irritability (HP:0000737)2.36694650
85Cardiovascular calcification (HP:0011915)2.34204877
86Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.33553440
87Spastic diplegia (HP:0001264)2.32592847
88Late onset (HP:0003584)2.32067936
89Sclerocornea (HP:0000647)2.31171488
90Neonatal onset (HP:0003623)2.29091030
91Systemic lupus erythematosus (HP:0002725)2.27997182
92Cystic liver disease (HP:0006706)2.27799107
93Reticulocytopenia (HP:0001896)2.25506119
94Increased hepatocellular lipid droplets (HP:0006565)2.25154833
95Hydroxyprolinuria (HP:0003080)2.24147945
96Abnormality of proline metabolism (HP:0010907)2.24147945
97Pancreatitis (HP:0001733)2.23817400
98Anencephaly (HP:0002323)2.23678057
99Chronic hepatic failure (HP:0100626)2.23468256
100Anophthalmia (HP:0000528)2.22378846
101Congenital stationary night blindness (HP:0007642)2.22263914
102Myocardial infarction (HP:0001658)2.22032725
103Septo-optic dysplasia (HP:0100842)2.18396442
104Skin nodule (HP:0200036)2.18042245
105Sensorimotor neuropathy (HP:0007141)2.17330259
106Hypochromic microcytic anemia (HP:0004840)2.16214429
107Postaxial foot polydactyly (HP:0001830)2.16149064
108Renal cortical cysts (HP:0000803)2.14763216
109Methylmalonic acidemia (HP:0002912)2.14700391
110Pendular nystagmus (HP:0012043)2.11443438
111Type II lissencephaly (HP:0007260)2.09522284
112Brushfield spots (HP:0001088)2.09012562
113Abnormal gallbladder morphology (HP:0012437)2.08594722
114Abnormal respiratory motile cilium physiology (HP:0012261)2.08364169
115Opisthotonus (HP:0002179)2.08083149
116Male pseudohermaphroditism (HP:0000037)2.06126329
117Abnormal respiratory motile cilium morphology (HP:0005938)2.05716847
118Abnormal respiratory epithelium morphology (HP:0012253)2.05716847
119Aplasia/Hypoplasia of the tongue (HP:0010295)2.04268444
120Bile duct proliferation (HP:0001408)2.03905160
121Abnormal biliary tract physiology (HP:0012439)2.03905160
122Abnormal gallbladder physiology (HP:0012438)2.03068436
123Cholecystitis (HP:0001082)2.03068436
124Mitral stenosis (HP:0001718)2.02836989
125Hepatic necrosis (HP:0002605)2.01667238
126Abnormal ciliary motility (HP:0012262)2.01271999
127Abnormality of alanine metabolism (HP:0010916)2.01012567
128Hyperalaninemia (HP:0003348)2.01012567
129Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.01012567
130Occipital encephalocele (HP:0002085)2.00215747
131Cholelithiasis (HP:0001081)2.00006496
132Postaxial hand polydactyly (HP:0001162)1.98567649
133Renal Fanconi syndrome (HP:0001994)1.98561267
134Rickets (HP:0002748)1.98313005
135Hypothermia (HP:0002045)1.98271499
136Acute encephalopathy (HP:0006846)1.96887971
137Hyperinsulinemic hypoglycemia (HP:0000825)1.96270711
138Acanthocytosis (HP:0001927)1.96108684
139Abnormality of the renal cortex (HP:0011035)1.96080091
140Hepatoblastoma (HP:0002884)1.95544433
141Poor coordination (HP:0002370)1.93843456
142Menorrhagia (HP:0000132)1.93304367
143Optic disc pallor (HP:0000543)1.93178498
144Adrenal hypoplasia (HP:0000835)1.90712002
145Amyloidosis (HP:0011034)1.90488024
146Hyperphosphaturia (HP:0003109)1.88438158
147Hyperactive renin-angiotensin system (HP:0000841)1.88259835
148Recurrent gram-negative bacterial infections (HP:0005420)1.88245720
149Nausea (HP:0002018)1.87618326
150Tubular atrophy (HP:0000092)1.87119577
151Glomerulonephritis (HP:0000099)1.86992864
152Preaxial hand polydactyly (HP:0001177)1.86507984
153Abnormal enzyme/coenzyme activity (HP:0012379)1.86412240
154Lissencephaly (HP:0001339)1.86409388
155Optic nerve hypoplasia (HP:0000609)1.86221594
156Elevated hepatic transaminases (HP:0002910)1.86125320
157Abolished electroretinogram (ERG) (HP:0000550)1.85484326
158Thrombophlebitis (HP:0004418)1.84129374
159Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.83906612
160Lactic acidosis (HP:0003128)1.83875782
161Confusion (HP:0001289)1.83128562
162Dynein arm defect of respiratory motile cilia (HP:0012255)1.82059472
163Absent/shortened dynein arms (HP:0200106)1.82059472
164Methylmalonic aciduria (HP:0012120)1.82039372
165Abnormality of vitamin metabolism (HP:0100508)1.81723641
166Intestinal atresia (HP:0011100)1.81448095
167Supernumerary spleens (HP:0009799)1.78678112
168Increased serum lactate (HP:0002151)1.76983466
169Bifid tongue (HP:0010297)1.74558001
170Cerebellar dysplasia (HP:0007033)1.74368970
171Aplasia/Hypoplasia of the tibia (HP:0005772)1.74053159
172Rib fusion (HP:0000902)1.72809773
173Congenital hepatic fibrosis (HP:0002612)1.72498009
174Rhinitis (HP:0012384)1.72268198
175CNS demyelination (HP:0007305)1.71360308
176Limb dystonia (HP:0002451)1.70982013
177Dandy-Walker malformation (HP:0001305)1.69246969
178Abnormal number of erythroid precursors (HP:0012131)1.63971838
179Short tibia (HP:0005736)1.63533669

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.61351107
2SIK13.94571580
3ERN13.66317077
4FGFR43.48518179
5MAPK153.20508326
6WNK32.85959035
7ZAK2.77454033
8TAOK32.53632058
9INSRR2.52581792
10PIK3CG2.38839386
11BMPR1B2.37805197
12WNK42.36860129
13MAP4K22.32410969
14CASK2.29347058
15FRK2.26231753
16DYRK22.15639838
17MAP2K72.08711883
18VRK22.06981758
19FLT31.97927129
20ERBB41.93122017
21NUAK11.92572349
22MST1R1.90436359
23TNIK1.86453435
24MAP2K41.85198984
25OXSR11.84049547
26ACVR1B1.81277485
27EPHA41.78185248
28MAP3K41.78078238
29MAPK131.68875638
30TRIM281.65047640
31STK38L1.63546577
32MAPK111.55226244
33VRK11.54636551
34TLK11.54242520
35CSNK1G21.52997251
36MARK11.52493806
37CSNK1G31.51241892
38PINK11.51029559
39NEK91.43388589
40PKN21.40965920
41KDR1.40097771
42MYLK1.37366301
43STK161.37053240
44ABL21.37048949
45MAP2K31.33012296
46BCR1.30803492
47MAP3K31.28421444
48CSNK1A1L1.28286496
49PTK61.25139292
50PBK1.24921973
51MKNK21.24433304
52TYK21.23121021
53DAPK21.18684835
54EPHB21.16017211
55NEK21.15872753
56DYRK31.13969954
57GRK61.13227011
58PAK31.12490700
59MAP3K71.10149065
60SRPK11.09663144
61NME11.08880429
62PLK31.07311711
63IRAK31.02102113
64PNCK1.01485906
65SGK20.98275971
66SGK2230.97037673
67SGK4940.97037673
68MAP3K110.96211388
69PRKAA20.95699748
70JAK20.95645032
71PIK3CA0.95429825
72WEE10.93556480
73MAP3K140.93540119
74TIE10.93353154
75PLK10.93212984
76MAPK40.91032066
77LIMK10.90480321
78PLK20.90313754
79MKNK10.89417619
80PHKG20.87746744
81PHKG10.87746744
82MAP3K120.86710804
83PLK40.82832754
84OBSCN0.82810743
85CDK190.81252410
86TBK10.80584193
87FGFR20.79843313
88NTRK30.75666714
89SGK30.74805352
90TGFBR20.74234597
91PRKCE0.72820117
92GSK3A0.72750861
93MAP2K60.72683474
94PRKCZ0.72602599
95TAF10.72502187
96CSNK1A10.72112730
97GRK10.71086613
98PDK30.70996191
99PDK40.70996191
100ADRBK10.70156719
101NTRK20.69132947
102IKBKE0.69002534
103CAMKK20.68975174
104PRKACG0.67598367
105TGFBR10.66190626
106MINK10.65760819
107CDC70.65576481
108TTK0.64854625
109DYRK1B0.64209193
110CAMK10.63248708
111TAOK20.60590427
112CAMK2G0.60521626
113MUSK0.58361357
114LATS10.57987563
115MAPK120.55472016
116TRIB30.55129220
117TEC0.54450374
118BRSK20.52089530
119ERBB30.52030361
120MST40.51583084
121CAMK1D0.51155948
122TSSK60.48832943
123JAK10.48570582
124RPS6KA50.46590421
125PRKAA10.46419019
126BTK0.45915887
127CSNK1E0.45000400
128ATR0.44707597
129CSNK2A10.43664191
130CAMK2A0.43212212
131PRKCI0.42668195
132RIPK10.42607323
133ERBB20.42022707
134NLK0.39971115
135CSNK2A20.39798346
136CAMK1G0.39492846
137PKN10.38351002
138DYRK1A0.38341506
139MAPK70.38208844
140AKT30.38134596
141PRKCG0.37902294
142KIT0.37507235
143CDK60.37058890
144MAP3K10.36771438
145PRKCQ0.32488566
146PRKCA0.31727840
147CSNK1G10.31535313
148STK390.30678602
149IRAK10.30517499
150PTK20.30038527
151PDPK10.29818003
152IGF1R0.29441532
153EPHB10.29204012
154PRKACA0.27578608
155MAP3K50.27421972
156CSK0.27370619
157DAPK10.27141422
158MAP3K100.25767955
159BMPR20.25728443
160MAP2K10.25558615
161GRK70.24603167
162NEK10.23735612
163CSF1R0.23337855
164MAP3K20.22093801
165MAP2K20.21982759
166LRRK20.20947982
167ADRBK20.19627330
168CAMK40.19447836
169PDK20.19117829
170PRKCD0.18928342
171MAPK30.17461289

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.07278036
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.44483697
3Nitrogen metabolism_Homo sapiens_hsa009102.97701618
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.96945434
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.77521820
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.69165888
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.68784423
8Tryptophan metabolism_Homo sapiens_hsa003802.68632302
9Arginine biosynthesis_Homo sapiens_hsa002202.67577990
10Fatty acid degradation_Homo sapiens_hsa000712.56632917
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.55582049
12Butanoate metabolism_Homo sapiens_hsa006502.50594105
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.45492581
14Propanoate metabolism_Homo sapiens_hsa006402.29473870
15Peroxisome_Homo sapiens_hsa041462.29040275
16Complement and coagulation cascades_Homo sapiens_hsa046102.26015539
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.19273592
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.15810326
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.94541767
20Chemical carcinogenesis_Homo sapiens_hsa052041.94287473
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.88201514
22Histidine metabolism_Homo sapiens_hsa003401.85861661
23Fatty acid metabolism_Homo sapiens_hsa012121.85566110
24Ribosome_Homo sapiens_hsa030101.83791390
25beta-Alanine metabolism_Homo sapiens_hsa004101.82485208
26PPAR signaling pathway_Homo sapiens_hsa033201.80915840
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.75005299
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.72096126
29Sulfur metabolism_Homo sapiens_hsa009201.70612725
30Pyruvate metabolism_Homo sapiens_hsa006201.65001846
31Retinol metabolism_Homo sapiens_hsa008301.60913397
32RNA polymerase_Homo sapiens_hsa030201.60206880
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.57863965
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.56551893
35Selenocompound metabolism_Homo sapiens_hsa004501.52098801
36Phenylalanine metabolism_Homo sapiens_hsa003601.48769645
37Fatty acid elongation_Homo sapiens_hsa000621.46710499
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44431708
39Caffeine metabolism_Homo sapiens_hsa002321.44221816
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42461686
41Bile secretion_Homo sapiens_hsa049761.42346713
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.41734737
43Starch and sucrose metabolism_Homo sapiens_hsa005001.34896891
44Tyrosine metabolism_Homo sapiens_hsa003501.32174428
45Staphylococcus aureus infection_Homo sapiens_hsa051501.31712976
46Proteasome_Homo sapiens_hsa030501.28779345
47Carbon metabolism_Homo sapiens_hsa012001.27817650
48Folate biosynthesis_Homo sapiens_hsa007901.26857546
49Phototransduction_Homo sapiens_hsa047441.26857190
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.25625150
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.25585467
52Maturity onset diabetes of the young_Homo sapiens_hsa049501.15003040
53Biosynthesis of amino acids_Homo sapiens_hsa012301.14957471
54Homologous recombination_Homo sapiens_hsa034401.14097104
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13519144
56Sulfur relay system_Homo sapiens_hsa041221.13238193
57Cardiac muscle contraction_Homo sapiens_hsa042601.13046949
58ABC transporters_Homo sapiens_hsa020101.06587172
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05132867
60Arginine and proline metabolism_Homo sapiens_hsa003301.02935235
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02443513
62Vitamin digestion and absorption_Homo sapiens_hsa049770.97264996
63Glutathione metabolism_Homo sapiens_hsa004800.95966010
64Fat digestion and absorption_Homo sapiens_hsa049750.94353695
65Fanconi anemia pathway_Homo sapiens_hsa034600.92936287
66Basal transcription factors_Homo sapiens_hsa030220.89143918
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88324567
68Steroid biosynthesis_Homo sapiens_hsa001000.86581608
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79663356
70Mismatch repair_Homo sapiens_hsa034300.75834498
71Nicotine addiction_Homo sapiens_hsa050330.75209116
72Ether lipid metabolism_Homo sapiens_hsa005650.74737005
73Lysine degradation_Homo sapiens_hsa003100.71724244
74Vitamin B6 metabolism_Homo sapiens_hsa007500.71673809
75Glycerolipid metabolism_Homo sapiens_hsa005610.70857598
76Base excision repair_Homo sapiens_hsa034100.70200195
77Pyrimidine metabolism_Homo sapiens_hsa002400.65805296
78Purine metabolism_Homo sapiens_hsa002300.64042772
79RNA degradation_Homo sapiens_hsa030180.61535770
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60831023
81Pentose phosphate pathway_Homo sapiens_hsa000300.60476698
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60118816
83Basal cell carcinoma_Homo sapiens_hsa052170.57910796
84Non-homologous end-joining_Homo sapiens_hsa034500.57863566
85Metabolic pathways_Homo sapiens_hsa011000.57678007
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57198211
87One carbon pool by folate_Homo sapiens_hsa006700.56902124
88Hedgehog signaling pathway_Homo sapiens_hsa043400.55189549
89Nucleotide excision repair_Homo sapiens_hsa034200.48036459
90Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.43850507
91Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.42307232
92Fructose and mannose metabolism_Homo sapiens_hsa000510.38570398
93DNA replication_Homo sapiens_hsa030300.36473608
94Galactose metabolism_Homo sapiens_hsa000520.35782110
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28613888
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27440640
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24825840
98Fatty acid biosynthesis_Homo sapiens_hsa000610.24730213
99Oxidative phosphorylation_Homo sapiens_hsa001900.22654909
100Linoleic acid metabolism_Homo sapiens_hsa005910.20259711
101Insulin resistance_Homo sapiens_hsa049310.17932969
102Prion diseases_Homo sapiens_hsa050200.13330188
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.13243669
104Parkinsons disease_Homo sapiens_hsa050120.10094741
105Glucagon signaling pathway_Homo sapiens_hsa049220.07026725
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.05434469
107Arachidonic acid metabolism_Homo sapiens_hsa005900.05304048
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.05255755
109Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1778374
110Mineral absorption_Homo sapiens_hsa04978-0.1733780
111Insulin signaling pathway_Homo sapiens_hsa04910-0.1626096
112Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1602369
113Protein digestion and absorption_Homo sapiens_hsa04974-0.1539962
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1437327
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1179927
116Huntingtons disease_Homo sapiens_hsa05016-0.0998300
117Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0826980
118Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0709694
119Renin-angiotensin system_Homo sapiens_hsa04614-0.0704415
120Regulation of autophagy_Homo sapiens_hsa04140-0.0633503
121AMPK signaling pathway_Homo sapiens_hsa04152-0.0391856
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0387723
123Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0279013
124Other glycan degradation_Homo sapiens_hsa00511-0.0248060
125Protein export_Homo sapiens_hsa03060-0.0159227
126Alzheimers disease_Homo sapiens_hsa05010-0.0038810

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