BPI

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antibacterial humoral response (GO:0019731)9.49249007
2sperm motility (GO:0030317)9.16914409
3fusion of sperm to egg plasma membrane (GO:0007342)9.05962174
4disruption of cells of other organism (GO:0044364)8.95075954
5killing of cells of other organism (GO:0031640)8.95075954
6antimicrobial humoral response (GO:0019730)8.82874586
7mucosal immune response (GO:0002385)8.60948022
8epithelial cilium movement (GO:0003351)8.36602210
9axonemal dynein complex assembly (GO:0070286)8.24180198
10organ or tissue specific immune response (GO:0002251)8.11305389
11proline biosynthetic process (GO:0006561)8.09955498
12cilium or flagellum-dependent cell motility (GO:0001539)7.98399705
13acrosome reaction (GO:0007340)7.78977481
14sperm-egg recognition (GO:0035036)7.72867338
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.70568529
16acrosome assembly (GO:0001675)7.70321358
17response to fungus (GO:0009620)7.59822235
18regulation of cilium movement (GO:0003352)7.54192121
19response to peptidoglycan (GO:0032494)7.40847633
20cell wall macromolecule metabolic process (GO:0044036)7.37656631
21cell wall macromolecule catabolic process (GO:0016998)7.37656631
22cellular extravasation (GO:0045123)7.25561367
23binding of sperm to zona pellucida (GO:0007339)7.09575386
24cell-cell recognition (GO:0009988)7.08189462
25spermatid development (GO:0007286)7.01691979
26seminiferous tubule development (GO:0072520)6.99043874
27multicellular organism reproduction (GO:0032504)6.98296393
28cilium movement (GO:0003341)6.95969716
29motile cilium assembly (GO:0044458)6.79865947
30plasma membrane fusion (GO:0045026)6.73557724
31detection of other organism (GO:0098543)6.68648143
32detection of bacterium (GO:0016045)6.65219512
33piRNA metabolic process (GO:0034587)6.60135537
34leukocyte migration involved in inflammatory response (GO:0002523)6.45970013
35negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)6.27111412
36sperm capacitation (GO:0048240)6.23002232
37single fertilization (GO:0007338)6.00261643
38proline metabolic process (GO:0006560)5.99240668
39neutrophil activation involved in immune response (GO:0002283)5.97326292
40killing of cells in other organism involved in symbiotic interaction (GO:0051883)5.96491496
41disruption of cells of other organism involved in symbiotic interaction (GO:0051818)5.96491496
42positive regulation of interleukin-8 biosynthetic process (GO:0045416)5.92222022
43synaptonemal complex organization (GO:0070193)5.85524499
44reproduction (GO:0000003)5.80573241
45male meiosis (GO:0007140)5.61986005
46neutrophil activation (GO:0042119)5.59053678
47transcription from mitochondrial promoter (GO:0006390)5.52992261
48fertilization (GO:0009566)5.51781979
49synaptonemal complex assembly (GO:0007130)5.44913235
50leukocyte aggregation (GO:0070486)5.41432549
51spermatogenesis (GO:0007283)5.08195503
52granulocyte activation (GO:0036230)5.08101108
53male gamete generation (GO:0048232)5.06340697
54defense response to Gram-positive bacterium (GO:0050830)5.03159748
55intracellular estrogen receptor signaling pathway (GO:0030520)4.91148362
56cell killing (GO:0001906)4.86434399
57DNA deamination (GO:0045006)4.84430203
58embryonic process involved in female pregnancy (GO:0060136)4.81654427
59oxygen transport (GO:0015671)4.80728626
60regulation of interleukin-8 biosynthetic process (GO:0045414)4.77934000
61replication fork processing (GO:0031297)4.72472047
62glycerol ether metabolic process (GO:0006662)4.72219637
63gamete generation (GO:0007276)4.69386602
64single strand break repair (GO:0000012)4.67784994
65response to host immune response (GO:0052572)4.67663798
66response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.67663798
67regulation of microtubule-based movement (GO:0060632)4.59491248
68establishment of apical/basal cell polarity (GO:0035089)4.59255209
69detection of external biotic stimulus (GO:0098581)4.57430312
70superoxide anion generation (GO:0042554)4.54541646
71negative regulation of inclusion body assembly (GO:0090084)4.53288378
72negative regulation of growth of symbiont involved in interaction with host (GO:0044146)4.46694569
73modulation of growth of symbiont involved in interaction with host (GO:0044144)4.46694569
74regulation of growth of symbiont in host (GO:0044126)4.46694569
75negative regulation of growth of symbiont in host (GO:0044130)4.46694569
76germ cell development (GO:0007281)4.37878005
77ether metabolic process (GO:0018904)4.33324639
78positive regulation of protein homooligomerization (GO:0032464)4.23240248
79detection of biotic stimulus (GO:0009595)4.21879789
80negative regulation of erythrocyte differentiation (GO:0045647)4.21857086
81respiratory burst (GO:0045730)4.21479082
82response to host (GO:0075136)4.20464971
83response to host defenses (GO:0052200)4.20464971
84response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.20464971
85protoporphyrinogen IX metabolic process (GO:0046501)4.20061544
86cellular process involved in reproduction in multicellular organism (GO:0022412)4.14320542
87oxidative demethylation (GO:0070989)4.11516449
88DNA strand renaturation (GO:0000733)4.09068698
89hemoglobin metabolic process (GO:0020027)4.04563814
90positive regulation of gamma-delta T cell activation (GO:0046645)4.04045830
91regulation of protein homooligomerization (GO:0032462)4.02004818
92protoporphyrinogen IX biosynthetic process (GO:0006782)4.01432902
93regulation of female gonad development (GO:2000194)4.00451477
94gas transport (GO:0015669)3.99612975
95organic cation transport (GO:0015695)3.98935538
96chromosome organization involved in meiosis (GO:0070192)3.97604398
97regulation of inclusion body assembly (GO:0090083)3.97060447
98establishment of monopolar cell polarity (GO:0061162)3.95907645
99establishment or maintenance of monopolar cell polarity (GO:0061339)3.95907645
100poly(A)+ mRNA export from nucleus (GO:0016973)3.90963954
101regulation of mast cell degranulation (GO:0043304)3.90114376
102DNA methylation involved in gamete generation (GO:0043046)3.89593100
103regulation of integrin activation (GO:0033623)3.86327794
104regulation of spindle checkpoint (GO:0090231)3.78948162
105positive regulation of toll-like receptor signaling pathway (GO:0034123)3.74166701
106microtubule depolymerization (GO:0007019)3.72867693
107male meiosis I (GO:0007141)3.71939754
108multicellular organismal reproductive process (GO:0048609)3.70409752
109neutrophil mediated immunity (GO:0002446)3.70236435
110meiotic nuclear division (GO:0007126)3.69343361
111protein polyglutamylation (GO:0018095)3.67467799
112maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.64427542
113regulation of myeloid leukocyte mediated immunity (GO:0002886)3.63798649
114regulation of mast cell activation involved in immune response (GO:0033006)3.61767009
115regulation of leukocyte degranulation (GO:0043300)3.61583819
116* defense response to bacterium (GO:0042742)3.61465747
117ventricular system development (GO:0021591)3.61465314
118mitochondrial DNA metabolic process (GO:0032042)3.60752421
119neutrophil chemotaxis (GO:0030593)3.57356629
120production of molecular mediator involved in inflammatory response (GO:0002532)3.54829173
121imidazole-containing compound metabolic process (GO:0052803)3.53075500
122axoneme assembly (GO:0035082)3.52942971
123regulation of podosome assembly (GO:0071801)3.51831842
124positive regulation of steroid hormone secretion (GO:2000833)3.48964250
125regulation of mast cell activation (GO:0033003)3.48749672
126neutrophil migration (GO:1990266)3.48551846
127somatic hypermutation of immunoglobulin genes (GO:0016446)3.46095880
128somatic diversification of immune receptors via somatic mutation (GO:0002566)3.46095880
129cellular response to ATP (GO:0071318)3.45602117
130regulation of protein polyubiquitination (GO:1902914)3.45374472
131phagosome maturation (GO:0090382)3.43845817
132leukocyte degranulation (GO:0043299)3.41795610
133genitalia morphogenesis (GO:0035112)3.40922029
134response to muramyl dipeptide (GO:0032495)3.39784030
135activated T cell proliferation (GO:0050798)3.38916990
136myeloid cell development (GO:0061515)3.37095332
137regulation of natural killer cell differentiation (GO:0032823)3.33506762
138chromosome condensation (GO:0030261)3.32727644
139positive regulation of mast cell activation (GO:0033005)3.30472660
140response to methylmercury (GO:0051597)3.29703173
141regulation of RNA export from nucleus (GO:0046831)3.29152791
142establishment of protein localization to mitochondrial membrane (GO:0090151)3.27515187
143regulation of regulated secretory pathway (GO:1903305)3.26883283
144mRNA cleavage (GO:0006379)3.25136645
145cell recognition (GO:0008037)3.24943393
146positive regulation of mast cell degranulation (GO:0043306)3.24190579
147positive regulation of mast cell activation involved in immune response (GO:0033008)3.24190579
148* response to bacterium (GO:0009617)3.21862566
149granulocyte migration (GO:0097530)3.21571651
150positive regulation of osteoblast proliferation (GO:0033690)3.20171064
151meiotic cell cycle (GO:0051321)3.19393026
152negative regulation of fatty acid biosynthetic process (GO:0045717)3.18626957
153glutamine family amino acid biosynthetic process (GO:0009084)3.16692100
154leukotriene biosynthetic process (GO:0019370)3.12286237
155DNA packaging (GO:0006323)3.10841253
156mast cell activation (GO:0045576)3.10474584
157negative regulation of cell cycle arrest (GO:0071157)3.09862666
158left/right pattern formation (GO:0060972)3.09238164
159citrulline biosynthetic process (GO:0019240)3.09057020
160regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.08968790
161calcium ion-dependent exocytosis (GO:0017156)3.06136159
162negative regulation of JAK-STAT cascade (GO:0046426)3.04076998
163positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.02551305
164positive regulation of B cell differentiation (GO:0045579)2.99193831
165myeloid cell activation involved in immune response (GO:0002275)2.99129261
166sex differentiation (GO:0007548)2.98143849
167leukotriene metabolic process (GO:0006691)2.98130955
168negative regulation of protein oligomerization (GO:0032460)2.97979161
169viral mRNA export from host cell nucleus (GO:0046784)2.95283733
170negative regulation of interleukin-12 production (GO:0032695)2.95014972
171erythrocyte development (GO:0048821)2.94971490
172meiosis I (GO:0007127)2.94870726
173granulocyte chemotaxis (GO:0071621)2.93509036
174carnitine transport (GO:0015879)2.93304959
175amino-acid betaine transport (GO:0015838)2.93304959
176microtubule severing (GO:0051013)2.91170831
177meiotic cell cycle process (GO:1903046)2.90557692
178multicellular organismal development (GO:0007275)2.89479342
179myeloid leukocyte mediated immunity (GO:0002444)2.89464518
180positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.89363018
181positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.89363018
182positive regulation of mitotic sister chromatid separation (GO:1901970)2.89363018
183modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.89212509
184positive regulation by organism of defense response of other organism involved in symbiotic interact2.89212509
185modulation by symbiont of host immune response (GO:0052553)2.89212509
186positive regulation by symbiont of host defense response (GO:0052509)2.89212509
187modulation by symbiont of host defense response (GO:0052031)2.89212509
188modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.89212509
189modification of morphology or physiology of other organism (GO:0035821)2.88745744
190positive regulation of protein oligomerization (GO:0032461)2.88001653
191intraciliary transport (GO:0042073)2.87730775
192regulation of B cell receptor signaling pathway (GO:0050855)2.86076702
193regulation of gamma-delta T cell activation (GO:0046643)2.85015552
194porphyrin-containing compound biosynthetic process (GO:0006779)2.82918412
195chronic inflammatory response (GO:0002544)2.82642679
196positive regulation of regulated secretory pathway (GO:1903307)2.81070575
197erythrocyte maturation (GO:0043249)2.80016368
198defense response to fungus (GO:0050832)10.1689663
199innate immune response in mucosa (GO:0002227)10.1440544

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.41869965
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.86454232
3MECOM_23826213_ChIP-Seq_KASUMI_Mouse4.03833273
4VDR_24763502_ChIP-Seq_THP-1_Human3.77850313
5SCL_19346495_ChIP-Seq_HPC-7_Human3.63703069
6MYB_21317192_ChIP-Seq_ERMYB_Mouse3.60799929
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.46598035
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.33488653
9GATA1_22025678_ChIP-Seq_K562_Human3.24803363
10IRF8_27001747_Chip-Seq_BMDM_Mouse3.16987675
11IRF8_21731497_ChIP-ChIP_J774_Mouse3.13357412
12RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.11419994
13* SPI1_23547873_ChIP-Seq_NB4_Human2.96166423
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.91984921
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.88208076
16GATA1_19941826_ChIP-Seq_K562_Human2.81347861
17SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.80929850
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.76265573
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.60006378
20VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.51303469
21VDR_24787735_ChIP-Seq_THP-1_Human2.47322046
22BRD4_27068464_Chip-Seq_AML-cells_Mouse2.44968991
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.44904360
24SPI1_23127762_ChIP-Seq_K562_Human2.44472351
25RUNX1_22412390_ChIP-Seq_EML_Mouse2.38846212
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.36421668
27TET1_21451524_ChIP-Seq_MESCs_Mouse2.23184250
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.18156575
29GATA1_19941827_ChIP-Seq_MEL_Mouse2.15381708
30MAF_26560356_Chip-Seq_TH1_Human2.13864517
31TCF7_22412390_ChIP-Seq_EML_Mouse2.13212401
32MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.11071575
33UTX_26944678_Chip-Seq_JUKART_Human2.09567824
34MYB_26560356_Chip-Seq_TH2_Human2.09248748
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.05657780
36Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.05538274
37ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.04282788
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.03997107
39RUNX_20019798_ChIP-Seq_JUKART_Human2.03886809
40NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.03503789
41TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.02644689
42SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98483804
43PU.1_20513432_ChIP-Seq_Bcells_Mouse1.97890890
44* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97683322
45FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.95724326
46GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.95668031
47FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.95612028
48GATA2_19941826_ChIP-Seq_K562_Human1.95328456
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.94435376
50PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.93635161
51VDR_22108803_ChIP-Seq_LS180_Human1.93351754
52RXRA_24833708_ChIP-Seq_LIVER_Mouse1.92509057
53E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.92288910
54MYC_22102868_ChIP-Seq_BL_Human1.91424248
55SPI1_26923725_Chip-Seq_HPCs_Mouse1.84781151
56SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.81896481
57LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.80162587
58LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.78016493
59EZH2_22144423_ChIP-Seq_EOC_Human1.77639352
60RARA_24833708_ChIP-Seq_LIVER_Mouse1.76056931
61CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.73990250
62MYB_26560356_Chip-Seq_TH1_Human1.73459894
63SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.73319639
64KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.71821959
65KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.71821959
66KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.71821959
67GATA1_22383799_ChIP-Seq_G1ME_Mouse1.70943363
68KDM2B_26808549_Chip-Seq_DND41_Human1.69576161
69RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.68757069
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.67140102
71POU5F1_16518401_ChIP-PET_MESCs_Mouse1.66869289
72KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.65725629
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.65620950
74LXR_22292898_ChIP-Seq_THP-1_Human1.64257886
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.62600921
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62325241
77KDM2B_26808549_Chip-Seq_SUP-B15_Human1.62156322
78EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61169346
79CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.60409574
80RARB_24833708_ChIP-Seq_LIVER_Mouse1.60045510
81RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.57426840
82ETS1_21867929_ChIP-Seq_TH2_Mouse1.56466885
83* BCOR_27268052_Chip-Seq_Bcells_Human1.55471613
84IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.54407390
85GATA2_22383799_ChIP-Seq_G1ME_Mouse1.52501186
86TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50548842
87FLI1_21867929_ChIP-Seq_CD8_Mouse1.48391063
88MYC_27129775_Chip-Seq_CORNEA_Mouse1.47197839
89KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.47055626
90RAD21_21589869_ChIP-Seq_MESCs_Mouse1.46443121
91PU_27001747_Chip-Seq_BMDM_Mouse1.46293145
92GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.45379437
93RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.45342990
94ELK4_26923725_Chip-Seq_MESODERM_Mouse1.42835234
95GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.41246003
96SOX2_22085726_ChIP-Seq_NPCs_Mouse1.41139567
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40980484
98KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.39122718
99PHF8_20622854_ChIP-Seq_HELA_Human1.38990151
100STAT1_20625510_ChIP-Seq_HELA_Human1.36311692
101PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34346651
102NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.33594455
103PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33519922
104MAF_26560356_Chip-Seq_TH2_Human1.33506336
105YY1_22570637_ChIP-Seq_MALME-3M_Human1.33140862
106SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.32336395
107E2F1_20622854_ChIP-Seq_HELA_Human1.31669028
108VDR_21846776_ChIP-Seq_THP-1_Human1.31402465
109SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31162245
110WDR5_24793694_ChIP-Seq_LNCAP_Human1.30656509
111CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29591650
112IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.29198361
113GATA3_27048872_Chip-Seq_THYMUS_Human1.29155184
114* BCL6_27268052_Chip-Seq_Bcells_Human1.28984273
115GATA3_26560356_Chip-Seq_TH2_Human1.28830677
116CTCF_27219007_Chip-Seq_Bcells_Human1.28073064
117ELF1_20517297_ChIP-Seq_JURKAT_Human1.27300318
118GATA1_26923725_Chip-Seq_HPCs_Mouse1.26877375
119ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26045495
120EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25395011
121ZNF263_19887448_ChIP-Seq_K562_Human1.22393411
122* CTCF_26484167_Chip-Seq_Bcells_Mouse1.21524977
123SMC4_20622854_ChIP-Seq_HELA_Human1.21218554
124SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19727256
125SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.18299798
126PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.17570731
127NCOR1_26117541_ChIP-Seq_K562_Human1.15491672
128SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14857446
129CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14463120
130STAT3_18555785_ChIP-Seq_MESCs_Mouse1.14460617
131ERG_21242973_ChIP-ChIP_JURKAT_Human1.14228818
132NANOG_21062744_ChIP-ChIP_HESCs_Human1.14047725
133PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.13007583
134FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11930575
135NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.11840504
136STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11415866
137GATA3_21867929_ChIP-Seq_TH1_Mouse1.09610239
138JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.09430281
139CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08844040
140CTCF_21964334_ChIP-Seq_BJAB-B_Human1.07856044
141DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07850954
142P68_20966046_ChIP-Seq_HELA_Human1.07713705
143PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06600531
144POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.06428583
145ELK3_25401928_ChIP-Seq_HUVEC_Human1.04181014
146NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.04037133
147SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03997446
148CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03724897
149CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02826982
150* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02534295
151TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01622685
152NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01514783
153ZNF274_21170338_ChIP-Seq_K562_Hela1.00872347
154SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.00810245
155NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00326858
156* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00214829
157NANOG_18692474_ChIP-Seq_MESCs_Mouse1.00059250
158* P300_27268052_Chip-Seq_Bcells_Human0.99650199
159OCT4_19829295_ChIP-Seq_ESCs_Human0.99492489
160TCF3_18692474_ChIP-Seq_MESCs_Mouse0.99412338
161LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.99203501
162KDM2B_26808549_Chip-Seq_JURKAT_Human0.98705555
163RAC3_21632823_ChIP-Seq_H3396_Human0.98157841
164TET1_21490601_ChIP-Seq_MESCs_Mouse0.97702914
165TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.97466413
166SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97398828
167KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97249440
168SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97091355
169NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96325184
170STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96269201
171SPI1_20517297_ChIP-Seq_HL60_Human0.95554659
172* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94911300
173* ESET_19884257_ChIP-Seq_ESCs_Mouse0.94823137
174REST_21632747_ChIP-Seq_MESCs_Mouse0.94670611
175SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.94017576
176SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.93996182
177* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92241879
178STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90178814
179STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88943210
180ELF1_17652178_ChIP-ChIP_JURKAT_Human0.88058897
181* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.82889723
182IKZF1_21737484_ChIP-ChIP_HCT116_Human0.81208855
183VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.81061532
184GATA1_19941827_ChIP-Seq_MEL86_Mouse0.80767185
185TFEB_21752829_ChIP-Seq_HELA_Human0.76209497

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.27438443
2MP0003303_peritoneal_inflammation4.80714817
3MP0003698_abnormal_male_reproductive4.27605305
4MP0008877_abnormal_DNA_methylation4.08406370
5MP0001929_abnormal_gametogenesis4.08309376
6MP0003436_decreased_susceptibility_to4.03064383
7MP0003656_abnormal_erythrocyte_physiolo3.87423026
8MP0009785_altered_susceptibility_to3.52707508
9MP0009278_abnormal_bone_marrow3.51483096
10MP0002419_abnormal_innate_immunity3.43753687
11MP0004233_abnormal_muscle_weight3.24202795
12MP0005025_abnormal_response_to3.17745110
13MP0002653_abnormal_ependyma_morphology3.09003854
14MP0003724_increased_susceptibility_to2.95363318
15MP0005171_absent_coat_pigmentation2.86157997
16MP0004147_increased_porphyrin_level2.82652549
17MP0001835_abnormal_antigen_presentation2.65663884
18MP0002210_abnormal_sex_determination2.64058754
19MP0005464_abnormal_platelet_physiology2.62769073
20MP0008995_early_reproductive_senescence2.54725815
21MP0002009_preneoplasia2.54172834
22MP0001145_abnormal_male_reproductive2.48331600
23MP0002161_abnormal_fertility/fecundity2.48011233
24MP0005000_abnormal_immune_tolerance2.30481102
25MP0002420_abnormal_adaptive_immunity2.22846825
26MP0001819_abnormal_immune_cell2.19345171
27MP0002138_abnormal_hepatobiliary_system2.16432526
28MP0002452_abnormal_antigen_presenting2.07914573
29MP0001790_abnormal_immune_system2.03884221
30MP0005387_immune_system_phenotype2.03884221
31MP0001800_abnormal_humoral_immune2.03815627
32MP0005410_abnormal_fertilization11.0115563
33MP0001533_abnormal_skeleton_physiology1.99989669
34MP0002148_abnormal_hypersensitivity_rea1.98635481
35MP0002723_abnormal_immune_serum1.98213261
36MP0000653_abnormal_sex_gland1.96662666
37MP0002282_abnormal_trachea_morphology1.94275155
38MP0008260_abnormal_autophagy1.90754795
39MP0002398_abnormal_bone_marrow1.87205929
40MP0003191_abnormal_cellular_cholesterol1.84692737
41MP0001545_abnormal_hematopoietic_system1.80627578
42MP0005397_hematopoietic_system_phenotyp1.80627578
43MP0010030_abnormal_orbit_morphology1.80103945
44MP0001851_eye_inflammation1.79836570
45MP0003300_gastrointestinal_ulcer1.76631210
46MP0001845_abnormal_inflammatory_respons1.74758139
47MP0000716_abnormal_immune_system1.67360326
48MP0004133_heterotaxia1.66049540
49MP0002722_abnormal_immune_system1.62453379
50MP0000465_gastrointestinal_hemorrhage1.59911980
51MP0003075_altered_response_to1.59685549
52MP0000689_abnormal_spleen_morphology1.59304779
53MP0003786_premature_aging1.58055199
54MP0010094_abnormal_chromosome_stability1.58044501
55MP0005083_abnormal_biliary_tract1.56698586
56MP0003890_abnormal_embryonic-extraembry1.55405408
57MP0005671_abnormal_response_to1.53655414
58MP0002166_altered_tumor_susceptibility1.50939694
59MP0002429_abnormal_blood_cell1.48748663
60MP0005174_abnormal_tail_pigmentation1.48330085
61MP0004808_abnormal_hematopoietic_stem1.48299384
62MP0006072_abnormal_retinal_apoptosis1.48141424
63MP0005647_abnormal_sex_gland1.47608613
64MP0002132_abnormal_respiratory_system1.45826790
65MP0004947_skin_inflammation1.45643666
66MP0009764_decreased_sensitivity_to1.45128808
67MP0002160_abnormal_reproductive_system1.43269362
68MP0003283_abnormal_digestive_organ1.40141205
69MP0008058_abnormal_DNA_repair1.38158488
70MP0005670_abnormal_white_adipose1.37916701
71MP0002396_abnormal_hematopoietic_system1.32313748
72MP0001293_anophthalmia1.26333217
73MP0000685_abnormal_immune_system1.22028242
74MP0010155_abnormal_intestine_physiology1.21853991
75MP0003763_abnormal_thymus_physiology1.17720161
76MP0008469_abnormal_protein_level1.15832849
77MP0002269_muscular_atrophy1.13989395
78MP0002249_abnormal_larynx_morphology1.13461316
79MP0000703_abnormal_thymus_morphology1.12236191
80MP0003119_abnormal_digestive_system1.11938446
81MP0003045_fibrosis1.09303524
82MP0004883_abnormal_blood_vessel1.08878271
83MP0009333_abnormal_splenocyte_physiolog1.06717454
84MP0005164_abnormal_response_to1.04022283
85MP0001853_heart_inflammation1.03092011
86MP0000579_abnormal_nail_morphology1.03087326
87MP0009115_abnormal_fat_cell1.01826173
88MP0005310_abnormal_salivary_gland1.01790490
89MP0000015_abnormal_ear_pigmentation1.01557888
90MP0002084_abnormal_developmental_patter1.00217636
91MP0002998_abnormal_bone_remodeling0.99932464
92MP0000462_abnormal_digestive_system0.99846627
93MP0002796_impaired_skin_barrier0.99470580
94MP0005076_abnormal_cell_differentiation0.98539150
95MP0000343_altered_response_to0.96196857
96MP0004510_myositis0.95818144
97MP0005623_abnormal_meninges_morphology0.94680744
98MP0003172_abnormal_lysosome_physiology0.93299652
99MP0000470_abnormal_stomach_morphology0.91291108
100MP0001324_abnormal_eye_pigmentation0.90905319
101MP0009765_abnormal_xenobiotic_induced0.89986799
102MP0001697_abnormal_embryo_size0.88571538
103MP0002006_tumorigenesis0.87401798
104MP0005058_abnormal_lysosome_morphology0.86771001
105MP0009763_increased_sensitivity_to0.86576063
106MP0003566_abnormal_cell_adhesion0.86127267
107MP0001663_abnormal_digestive_system0.86070652
108MP0003221_abnormal_cardiomyocyte_apopto0.85380386
109MP0003453_abnormal_keratinocyte_physiol0.84954498
110MP0000858_altered_metastatic_potential0.84762553
111MP0005166_decreased_susceptibility_to0.84567426
112MP0005389_reproductive_system_phenotype0.84273107
113MP0002086_abnormal_extraembryonic_tissu0.82687971
114MP0001348_abnormal_lacrimal_gland0.82578154
115MP0002085_abnormal_embryonic_tissue0.81500857
116MP0004197_abnormal_fetal_growth/weight/0.80431636
117MP0005390_skeleton_phenotype0.79299420
118MP0001986_abnormal_taste_sensitivity0.78710055
119MP0000371_diluted_coat_color0.78062518
120MP0000639_abnormal_adrenal_gland0.77942118
121MP0004134_abnormal_chest_morphology0.77596997
122MP0000604_amyloidosis0.77337271
123MP0001340_abnormal_eyelid_morphology0.76198124
124MP0003795_abnormal_bone_structure0.75991729
125MP0004264_abnormal_extraembryonic_tissu0.74544759
126MP0000249_abnormal_blood_vessel0.74038849
127MP0003111_abnormal_nucleus_morphology0.73990584
128MP0003183_abnormal_peptide_metabolism0.73942988
129MP0000609_abnormal_liver_physiology0.73571692
130MP0008932_abnormal_embryonic_tissue0.73426267
131MP0005645_abnormal_hypothalamus_physiol0.72287563
132MP0004957_abnormal_blastocyst_morpholog0.71109898
133MP0008004_abnormal_stomach_pH0.70698904
134MP0009931_abnormal_skin_appearance0.70067323
135MP0002108_abnormal_muscle_morphology0.69501380
136MP0002932_abnormal_joint_morphology0.68602082
137MP0009840_abnormal_foam_cell0.68415345
138MP0002971_abnormal_brown_adipose0.67492118
139MP0005075_abnormal_melanosome_morpholog0.67410876
140MP0003448_altered_tumor_morphology0.67391906
141MP0006082_CNS_inflammation0.65456264
142MP0001672_abnormal_embryogenesis/_devel0.65329401
143MP0005380_embryogenesis_phenotype0.65329401
144MP0004185_abnormal_adipocyte_glucose0.63578187
145MP0004019_abnormal_vitamin_homeostasis0.63576066
146MP0002405_respiratory_system_inflammati0.63511746
147MP0005253_abnormal_eye_physiology0.63221829
148MP0002114_abnormal_axial_skeleton0.61271350
149MP0003690_abnormal_glial_cell0.60912278
150MP0001730_embryonic_growth_arrest0.60373902
151MP0005636_abnormal_mineral_homeostasis0.58169683
152MP0004130_abnormal_muscle_cell0.58111047
153MP0003866_abnormal_defecation0.57695148
154MP0005391_vision/eye_phenotype0.57221326
155MP0003699_abnormal_female_reproductive0.57074204
156MP0002877_abnormal_melanocyte_morpholog0.56512302
157MP0009046_muscle_twitch0.56265121
158MP0002095_abnormal_skin_pigmentation0.55854126
159MP0005319_abnormal_enzyme/_coenzyme0.55031035
160MP0004381_abnormal_hair_follicle0.54725154
161MP0005535_abnormal_body_temperature0.54049248
162MP0002970_abnormal_white_adipose0.53223830
163MP0002116_abnormal_craniofacial_bone0.48834320
164MP0000467_abnormal_esophagus_morphology0.48501630
165MP0003936_abnormal_reproductive_system0.47917537
166MP0005266_abnormal_metabolism0.47822347
167MP0001873_stomach_inflammation0.47030890
168MP0000432_abnormal_head_morphology0.45980120
169MP0002080_prenatal_lethality0.45631769
170MP0010352_gastrointestinal_tract_polyps0.45525006
171MP0010307_abnormal_tumor_latency0.45515781
172MP0005501_abnormal_skin_physiology0.44702444
173MP0000313_abnormal_cell_death0.43663484
174MP0002019_abnormal_tumor_incidence0.43352710
175MP0005365_abnormal_bile_salt0.42240096
176MP0002075_abnormal_coat/hair_pigmentati0.41969626
177MP0001764_abnormal_homeostasis0.41399220
178MP0003828_pulmonary_edema0.41315510
179MP0003115_abnormal_respiratory_system0.41249264
180MP0003984_embryonic_growth_retardation0.40265386
181MP0010630_abnormal_cardiac_muscle0.39378445
182MP0003861_abnormal_nervous_system0.39290453

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.86804715
2Absent/shortened dynein arms (HP:0200106)9.49709454
3Dynein arm defect of respiratory motile cilia (HP:0012255)9.49709454
4Abnormal respiratory epithelium morphology (HP:0012253)8.36135726
5Abnormal respiratory motile cilium morphology (HP:0005938)8.36135726
6Abnormality of the heme biosynthetic pathway (HP:0010472)6.99353042
7Abnormal respiratory motile cilium physiology (HP:0012261)6.99069649
8Infertility (HP:0000789)6.51174394
9Recurrent abscess formation (HP:0002722)6.12660185
10Eczematoid dermatitis (HP:0000976)6.06069788
11Recurrent bacterial skin infections (HP:0005406)5.93714548
12Rhinitis (HP:0012384)5.84405569
13Male infertility (HP:0003251)5.70916372
14Abnormal ciliary motility (HP:0012262)5.48870999
15Chronic bronchitis (HP:0004469)5.24382619
16Abnormality of macrophages (HP:0004311)5.23420316
17Recurrent gram-negative bacterial infections (HP:0005420)5.04138939
18Nasal polyposis (HP:0100582)4.85691700
19Hypochromic anemia (HP:0001931)4.79810259
20Stomatitis (HP:0010280)4.51433346
21Poikilocytosis (HP:0004447)4.37455563
22Obstructive lung disease (HP:0006536)4.15326891
23Chronic obstructive pulmonary disease (HP:0006510)4.15326891
24Prolonged bleeding time (HP:0003010)3.99739574
25Abnormality of the nasal mucosa (HP:0000433)3.94833936
26Microcytic anemia (HP:0001935)3.92372335
27Increased cerebral lipofuscin (HP:0011813)3.84606478
28Myositis (HP:0100614)3.81879580
29Recurrent skin infections (HP:0001581)3.72475431
30Recurrent fungal infections (HP:0002841)3.72140544
31Abnormal delayed hypersensitivity skin test (HP:0002963)3.69767579
32Bronchiectasis (HP:0002110)3.68397600
33Increased neuronal autofluorescent lipopigment (HP:0002074)3.64764465
34Mediastinal lymphadenopathy (HP:0100721)3.64036361
35Gingivitis (HP:0000230)3.55251198
36Urticaria (HP:0001025)3.31329089
37Systemic lupus erythematosus (HP:0002725)3.29277566
38Gastrointestinal infarctions (HP:0005244)3.28004779
39Concave nail (HP:0001598)3.24013300
40Epistaxis (HP:0000421)3.23964535
41Meningitis (HP:0001287)3.22243025
42Abnormality of liposaccharide metabolism (HP:0010968)3.21759297
43Abnormality of glycosphingolipid metabolism (HP:0004343)3.21759297
44Abnormality of glycolipid metabolism (HP:0010969)3.21759297
45Petechiae (HP:0000967)3.21353545
46Alopecia of scalp (HP:0002293)3.20126591
47Short humerus (HP:0005792)3.19025198
48Abnormality of iron homeostasis (HP:0011031)3.17562647
49Recurrent cutaneous fungal infections (HP:0011370)3.16853792
50Chronic mucocutaneous candidiasis (HP:0002728)3.16853792
51Pustule (HP:0200039)3.12059311
52Bronchitis (HP:0012387)3.09950198
53Abnormality of the lower motor neuron (HP:0002366)3.09839550
54Rib fusion (HP:0000902)3.06711392
55Elevated erythrocyte sedimentation rate (HP:0003565)3.04963972
56Annular pancreas (HP:0001734)3.02370070
57Amyloidosis (HP:0011034)2.99406034
58Tongue fasciculations (HP:0001308)2.98228268
59Orchitis (HP:0100796)2.98158489
60Increased IgM level (HP:0003496)2.96449759
61Facial hemangioma (HP:0000329)2.95341213
62Aplasia/hypoplasia of the humerus (HP:0006507)2.94849280
63Optic neuritis (HP:0100653)2.94690391
64Retrobulbar optic neuritis (HP:0100654)2.94690391
65Poikiloderma (HP:0001029)2.94456824
66Cellulitis (HP:0100658)2.94391927
67Nephronophthisis (HP:0000090)2.92658138
68Toxemia of pregnancy (HP:0100603)2.92291212
69Rectal fistula (HP:0100590)2.92088182
70Rectovaginal fistula (HP:0000143)2.92088182
71Autoimmune thrombocytopenia (HP:0001973)2.88415381
72Osteomyelitis (HP:0002754)2.86005196
73Abnormal platelet volume (HP:0011876)2.83621472
74Paralysis (HP:0003470)2.80359446
75Gingival bleeding (HP:0000225)2.78285679
76Muscle fibrillation (HP:0010546)2.77096251
77Turricephaly (HP:0000262)2.75307313
78Recurrent otitis media (HP:0000403)2.69481475
79Granulocytopenia (HP:0001913)2.68219671
80Abnormality of transition element cation homeostasis (HP:0011030)2.68084882
81Keratoconjunctivitis sicca (HP:0001097)2.67436742
82Increased IgE level (HP:0003212)2.66882475
83Episodic fever (HP:0001954)2.65943767
84Cholelithiasis (HP:0001081)2.62417753
85Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.61852065
86Recurrent viral infections (HP:0004429)2.61686913
87Ulnar bowing (HP:0003031)2.61125380
88Anorexia (HP:0002039)2.56465551
89Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.54732984
90Leukocytosis (HP:0001974)2.53504779
91Intestinal fistula (HP:0100819)2.52448998
92Vaginal fistula (HP:0004320)2.51500886
93Clumsiness (HP:0002312)2.50573764
94Increased serum ferritin (HP:0003281)2.48179584
95Coronal craniosynostosis (HP:0004440)2.47073805
96Keratoconjunctivitis (HP:0001096)2.44498804
97Vasculitis (HP:0002633)2.44000735
98Hepatosplenomegaly (HP:0001433)2.43490849
99Choroideremia (HP:0001139)2.42102720
100Hemoptysis (HP:0002105)2.41281575
101Encephalitis (HP:0002383)2.37818811
102Abnormality of B cell number (HP:0010975)2.34180694
103Increased mean platelet volume (HP:0011877)2.34078728
104Abnormality of male internal genitalia (HP:0000022)2.33483880
105Pulmonary infiltrates (HP:0002113)2.32352365
106Abnormal gallbladder morphology (HP:0012437)2.31930761
107Bulbar palsy (HP:0001283)2.30974091
108Abnormality of the fingertips (HP:0001211)2.30893880
109Hypochromic microcytic anemia (HP:0004840)2.27004886
110Reticulocytosis (HP:0001923)2.26262463
111Gonadotropin excess (HP:0000837)2.26226176
112Spontaneous hematomas (HP:0007420)2.25180604
113Chest pain (HP:0100749)2.21528506
114Impulsivity (HP:0100710)2.20262820
115Squamous cell carcinoma (HP:0002860)2.18970635
116Intestinal atresia (HP:0011100)2.18416387
117Asymmetric septal hypertrophy (HP:0001670)2.15827663
118Abnormality of T cell physiology (HP:0011840)2.15301437
119Abnormality of the renal medulla (HP:0100957)2.15155261
120Purpura (HP:0000979)2.14374584
121Abnormality of pyrimidine metabolism (HP:0004353)2.12164840
122Median cleft lip (HP:0000161)2.11848442
123Recurrent sinusitis (HP:0011108)2.10469642
124Abnormal spermatogenesis (HP:0008669)2.09400534
125Selective tooth agenesis (HP:0001592)2.05433438
126Arterial thrombosis (HP:0004420)2.02425176
127Medial flaring of the eyebrow (HP:0010747)2.02024400
128Abnormal platelet function (HP:0011869)2.01955171
129Impaired platelet aggregation (HP:0003540)2.01955171
130Dysostosis multiplex (HP:0000943)2.01217819
131Vacuolated lymphocytes (HP:0001922)2.01052600
132Polygenic inheritance (HP:0010982)2.00090635
133Heterotopia (HP:0002282)1.99497805
134Eosinophilia (HP:0001880)1.99022150
135Disinhibition (HP:0000734)1.98919988
136Thrombophlebitis (HP:0004418)1.97770030
137B lymphocytopenia (HP:0010976)1.97483037
138Abnormal hemoglobin (HP:0011902)1.97441376
139Inflammation of the large intestine (HP:0002037)1.96917003
140Albinism (HP:0001022)1.96721959
141Orthostatic hypotension (HP:0001278)1.96466920
142Menorrhagia (HP:0000132)1.94451536
143Hypotelorism (HP:0000601)1.92510351
144Autoimmune hemolytic anemia (HP:0001890)1.90895264
145Short chin (HP:0000331)1.90109932
146Skin rash (HP:0000988)1.89828726
147Mucopolysacchariduria (HP:0008155)1.88145369
148Urinary glycosaminoglycan excretion (HP:0003541)1.88145369
149Growth hormone excess (HP:0000845)1.88108760
150Tubular atrophy (HP:0000092)1.87715565
151Colitis (HP:0002583)1.87122967
152Absent thumb (HP:0009777)1.86883239
153Skin ulcer (HP:0200042)1.85698500
154Diaphragmatic weakness (HP:0009113)1.83997581
155Gastrointestinal inflammation (HP:0004386)1.83776724
156Large for gestational age (HP:0001520)1.83344548
157Sepsis (HP:0100806)1.82988179
158Panhypogammaglobulinemia (HP:0003139)1.82863261
159Hypercortisolism (HP:0001578)1.81325341
160Broad alveolar ridges (HP:0000187)1.80893855
161Anteriorly placed anus (HP:0001545)1.80212599
162Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.79605112
163Absent radius (HP:0003974)1.78561552
164Alacrima (HP:0000522)1.77612515
165Hamartoma (HP:0010566)1.75137409
166Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.74623472
167Vertebral hypoplasia (HP:0008417)1.74623472
168Congenital hip dislocation (HP:0001374)1.73936263
169Postaxial foot polydactyly (HP:0001830)1.73087638
170Exercise-induced myalgia (HP:0003738)1.72509115
171Abnormality of the aortic arch (HP:0012303)1.71667200
172Hypotrichosis (HP:0001006)1.69243948
173Recurrent bronchitis (HP:0002837)1.66995250
174Aplasia involving forearm bones (HP:0009822)1.66632363
175Absent forearm bone (HP:0003953)1.66632363
176Abnormality of abdominal situs (HP:0011620)1.65170881
177Abdominal situs inversus (HP:0003363)1.65170881
178Hypoplasia of the radius (HP:0002984)1.65122710
179Type 2 muscle fiber atrophy (HP:0003554)1.61902124
180Abnormality of mucopolysaccharide metabolism (HP:0011020)1.60702621
181Abnormality of polysaccharide metabolism (HP:0011012)1.60702621
182Abnormality of glycosaminoglycan metabolism (HP:0004371)1.60702621
183Supernumerary spleens (HP:0009799)1.60502149
184Dysautonomia (HP:0002459)1.60463344
185Basal cell carcinoma (HP:0002671)1.59628904
186Tubulointerstitial fibrosis (HP:0005576)1.59085663
187Polycythemia (HP:0001901)1.58885996
188Abnormality of the neuromuscular junction (HP:0003398)1.58683424
189Fatigable weakness (HP:0003473)1.58683424
190Polydipsia (HP:0001959)1.56510470
191Abnormal drinking behavior (HP:0030082)1.56510470
192Muscle fiber atrophy (HP:0100295)1.55602554

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK7.14062338
2MAPK154.73463970
3PDK44.71297296
4PDK34.71297296
5MAP2K34.64607349
6RIPK44.63571396
7BLK4.15709213
8DDR23.58939410
9TESK13.46927849
10MAP3K63.36050966
11GRK63.34388248
12PINK13.06180425
13PDK22.99598061
14PRKD32.81683828
15TYRO32.78969431
16DYRK1B2.75989463
17IRAK42.43100003
18FES2.38714437
19MAP3K112.14663096
20ZAP702.09877377
21MAP3K32.06201753
22BTK2.03996449
23TEC2.01134702
24MATK1.98413224
25FGR1.94702630
26PIK3CG1.89054950
27SYK1.88856938
28TAOK21.78709308
29MAP4K11.76941053
30UHMK11.65372077
31CSK1.63607644
32TYK21.63277031
33DAPK11.57686561
34DYRK31.55430559
35YES11.54004271
36PIM21.51795588
37PRKD21.49158864
38BMX1.48990481
39ERN11.45330277
40PDGFRA1.41974777
41NEK21.40634722
42PIK3CA1.40590256
43MAP3K141.38950131
44HCK1.34241110
45STK381.31902474
46IRAK11.31092753
47PTK2B1.26125944
48JAK21.24576148
49MAP3K11.22675540
50STK391.18334279
51KSR21.16264103
52IRAK21.12646644
53MARK31.12416491
54WNK41.12332996
55MAP2K41.11017962
56MAP3K51.08288037
57EPHB11.07811238
58ITK1.06175938
59KIT1.03290633
60CDK61.02296661
61TXK0.98730576
62PIM10.98217391
63CDK70.97834379
64MAP3K130.97628967
65AKT30.94567284
66IKBKE0.91788746
67MAPK120.91742521
68CHEK20.90402266
69CAMK1D0.82901279
70LATS20.82617390
71CDC42BPA0.81936332
72TBK10.80305279
73BMPR20.80147505
74RPS6KC10.78202369
75RPS6KL10.78202369
76PDPK10.77310138
77GSK3A0.76972658
78LCK0.76903835
79MAPK70.76134027
80JAK30.75312361
81STK30.75246683
82RET0.75203048
83EPHA30.74360849
84IKBKB0.72338708
85MAP2K60.71380693
86DAPK20.70234449
87CDK120.70167858
88TRPM70.69616995
89PHKG10.66942863
90PHKG20.66942863
91RPS6KA60.66221547
92MTOR0.65604452
93MAP3K100.63563181
94JAK10.63500332
95CLK10.63237759
96PRKAA10.61631955
97SIK30.58743462
98MAP3K20.56539593
99SGK30.53358791
100CSF1R0.52840590
101MAPK110.51912293
102RPS6KA10.51861324
103TGFBR20.51478315
104PLK10.50013313
105TAOK30.49814410
106FYN0.49660047
107ATR0.47476024
108CAMK1G0.46834531
109PNCK0.45333588
110KSR10.45087825
111PRKCQ0.44730160
112STK110.44346591
113MAP3K70.43534396
114MAP2K20.41763743
115CAMKK20.40756877
116RPS6KA20.40686950
117MAPKAPK20.39679826
118RPS6KB10.39251846
119TNK20.38020587
120CHEK10.37869514
121SGK20.37120094
122NTRK20.37096838
123EGFR0.35074130
124ABL10.34557960
125PDGFRB0.33596068
126SIK20.33051248
127STK38L0.32699082
128HIPK20.32524446
129PDK10.32340206
130CSNK2A10.31900335
131ATM0.31557411
132PAK20.30892077
133TTK0.29934466
134CDK190.28620088
135CAMK40.28575743
136PAK10.27694041
137PRKCZ0.27370106
138CDK20.25669910
139MARK20.22927916
140CAMK2G0.21662074
141TESK20.20930580
142MAPK10.20534331
143STK100.20527332
144CAMK2B0.19961851
145INSR0.19328426
146CAMK2A0.19305819
147WNK10.18216747
148ERBB30.16880056
149MAPK100.16077840
150TRIB30.14917556
151AURKA0.14653281
152PRPF4B0.14042525
153CSNK2A20.13637362
154MAPK140.13317811
155PRKAA20.13217627
156PRKCD0.13038154
157CDC70.12845485
158CDK10.12740685
159GSK3B0.12681347
160LYN0.12404540
161RAF10.11973851
162MAPK30.11718224
163CDK150.11202594
164MAPK40.10901564
165CDK11A0.10658250
166PTK20.10063040
167PRKACG0.09649473
168WEE10.08426767
169RPS6KA30.08191063
170TAOK10.08088388

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000617.47620349
2Base excision repair_Homo sapiens_hsa034103.31779692
3Mismatch repair_Homo sapiens_hsa034302.98029351
4Osteoclast differentiation_Homo sapiens_hsa043802.85421247
5Asthma_Homo sapiens_hsa053102.71191880
6Staphylococcus aureus infection_Homo sapiens_hsa051502.69087320
7Malaria_Homo sapiens_hsa051442.68086438
8Leishmaniasis_Homo sapiens_hsa051402.67440882
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.29204328
10DNA replication_Homo sapiens_hsa030302.21912118
11Other glycan degradation_Homo sapiens_hsa005112.19298453
12Hedgehog signaling pathway_Homo sapiens_hsa043402.13360519
13Tuberculosis_Homo sapiens_hsa051522.12577341
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.12260408
15Fatty acid metabolism_Homo sapiens_hsa012122.11053092
16mRNA surveillance pathway_Homo sapiens_hsa030152.09966325
17Linoleic acid metabolism_Homo sapiens_hsa005912.08048094
18Fanconi anemia pathway_Homo sapiens_hsa034601.99199441
19Pyruvate metabolism_Homo sapiens_hsa006201.96764477
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.93928287
21Vitamin B6 metabolism_Homo sapiens_hsa007501.90360333
22Dorso-ventral axis formation_Homo sapiens_hsa043201.88775016
23Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.87950747
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.82959810
25African trypanosomiasis_Homo sapiens_hsa051431.81581325
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.78020917
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.74731781
28Hematopoietic cell lineage_Homo sapiens_hsa046401.69275755
29Glutathione metabolism_Homo sapiens_hsa004801.66811245
30Oocyte meiosis_Homo sapiens_hsa041141.62738590
31Biosynthesis of amino acids_Homo sapiens_hsa012301.61960656
32RNA transport_Homo sapiens_hsa030131.60352339
33Glucagon signaling pathway_Homo sapiens_hsa049221.58163801
34Non-small cell lung cancer_Homo sapiens_hsa052231.55302871
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.53276570
36Fructose and mannose metabolism_Homo sapiens_hsa000511.52848851
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.52403169
38Arginine and proline metabolism_Homo sapiens_hsa003301.45900382
39Glycerolipid metabolism_Homo sapiens_hsa005611.44265888
40Lysosome_Homo sapiens_hsa041421.36570644
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.36270113
42Platelet activation_Homo sapiens_hsa046111.35578047
43Selenocompound metabolism_Homo sapiens_hsa004501.34880370
44mTOR signaling pathway_Homo sapiens_hsa041501.34014848
45Phagosome_Homo sapiens_hsa041451.33724849
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.32490909
47Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32028947
48Circadian rhythm_Homo sapiens_hsa047101.31166866
49Chemokine signaling pathway_Homo sapiens_hsa040621.29596963
50Pertussis_Homo sapiens_hsa051331.28829394
51Hippo signaling pathway_Homo sapiens_hsa043901.28444572
52Longevity regulating pathway - mammal_Homo sapiens_hsa042111.26994183
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.24551952
54Propanoate metabolism_Homo sapiens_hsa006401.23428998
55Basal transcription factors_Homo sapiens_hsa030221.23282131
56Pancreatic cancer_Homo sapiens_hsa052121.20936807
57Arachidonic acid metabolism_Homo sapiens_hsa005901.18161022
58Toxoplasmosis_Homo sapiens_hsa051451.17718719
59Influenza A_Homo sapiens_hsa051641.17458928
60VEGF signaling pathway_Homo sapiens_hsa043701.16815931
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.16326799
62Amoebiasis_Homo sapiens_hsa051461.15934350
63TNF signaling pathway_Homo sapiens_hsa046681.15260910
64Jak-STAT signaling pathway_Homo sapiens_hsa046301.14642201
65Chronic myeloid leukemia_Homo sapiens_hsa052201.14355969
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.14331140
67Hepatitis B_Homo sapiens_hsa051611.12940377
68Measles_Homo sapiens_hsa051621.09699728
69T cell receptor signaling pathway_Homo sapiens_hsa046601.09400551
70Nucleotide excision repair_Homo sapiens_hsa034201.08569988
71Notch signaling pathway_Homo sapiens_hsa043301.07997597
72Fat digestion and absorption_Homo sapiens_hsa049751.07518949
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05190378
74Type II diabetes mellitus_Homo sapiens_hsa049301.03489419
75Wnt signaling pathway_Homo sapiens_hsa043101.02352943
76NF-kappa B signaling pathway_Homo sapiens_hsa040641.01590119
77Renal cell carcinoma_Homo sapiens_hsa052111.01055252
78Adherens junction_Homo sapiens_hsa045201.00306705
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.95466866
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.95458246
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.94306394
82Mineral absorption_Homo sapiens_hsa049780.93966160
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.93579809
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93574317
85Basal cell carcinoma_Homo sapiens_hsa052170.92987916
86Salmonella infection_Homo sapiens_hsa051320.92357970
87Homologous recombination_Homo sapiens_hsa034400.91803518
88Amphetamine addiction_Homo sapiens_hsa050310.91297387
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90680559
90Regulation of autophagy_Homo sapiens_hsa041400.86910192
91HIF-1 signaling pathway_Homo sapiens_hsa040660.86593737
92FoxO signaling pathway_Homo sapiens_hsa040680.85913576
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85115139
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.84889532
95p53 signaling pathway_Homo sapiens_hsa041150.84154806
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81514465
97Spliceosome_Homo sapiens_hsa030400.80506486
98Sulfur relay system_Homo sapiens_hsa041220.79867307
99Herpes simplex infection_Homo sapiens_hsa051680.78744526
100Prolactin signaling pathway_Homo sapiens_hsa049170.78737815
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77903029
102GnRH signaling pathway_Homo sapiens_hsa049120.76786211
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76650930
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76630631
105Hepatitis C_Homo sapiens_hsa051600.76003195
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.75852196
107Shigellosis_Homo sapiens_hsa051310.75532363
108Apoptosis_Homo sapiens_hsa042100.74684491
109Collecting duct acid secretion_Homo sapiens_hsa049660.73929261
110Rheumatoid arthritis_Homo sapiens_hsa053230.73502890
111PPAR signaling pathway_Homo sapiens_hsa033200.73500030
112Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72728881
113AMPK signaling pathway_Homo sapiens_hsa041520.72676173
114Cysteine and methionine metabolism_Homo sapiens_hsa002700.70999289
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70039331
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69269374
117Nitrogen metabolism_Homo sapiens_hsa009100.69086729
118Graft-versus-host disease_Homo sapiens_hsa053320.68500363
119Systemic lupus erythematosus_Homo sapiens_hsa053220.68316520
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66987925
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66931553
122Allograft rejection_Homo sapiens_hsa053300.66912568
123Endometrial cancer_Homo sapiens_hsa052130.66415097
124TGF-beta signaling pathway_Homo sapiens_hsa043500.64587285
125Legionellosis_Homo sapiens_hsa051340.64476282
126Inositol phosphate metabolism_Homo sapiens_hsa005620.63186875
127Pentose phosphate pathway_Homo sapiens_hsa000300.62543845
128Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.62506923
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.61859786
130Autoimmune thyroid disease_Homo sapiens_hsa053200.59709225
131Estrogen signaling pathway_Homo sapiens_hsa049150.59601589
132Intestinal immune network for IgA production_Homo sapiens_hsa046720.59055597
133Tight junction_Homo sapiens_hsa045300.58777797
134Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58653877
135Phospholipase D signaling pathway_Homo sapiens_hsa040720.57030558
136ABC transporters_Homo sapiens_hsa020100.55222450
137Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54701572
138Maturity onset diabetes of the young_Homo sapiens_hsa049500.53753923
139Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52513068
140Cell cycle_Homo sapiens_hsa041100.52113647
141Thyroid hormone synthesis_Homo sapiens_hsa049180.52101246
142Central carbon metabolism in cancer_Homo sapiens_hsa052300.51866535
143Glioma_Homo sapiens_hsa052140.51742050
144Prostate cancer_Homo sapiens_hsa052150.51595528
145Insulin resistance_Homo sapiens_hsa049310.49408070
146Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48566437
147Ether lipid metabolism_Homo sapiens_hsa005650.48563879
148Endocytosis_Homo sapiens_hsa041440.47114235
149Cardiac muscle contraction_Homo sapiens_hsa042600.44283370
150Huntingtons disease_Homo sapiens_hsa050160.43710433
151Complement and coagulation cascades_Homo sapiens_hsa046100.42560242
152Bladder cancer_Homo sapiens_hsa052190.41393878
153Colorectal cancer_Homo sapiens_hsa052100.40775316
154Carbon metabolism_Homo sapiens_hsa012000.39933729
155Lysine degradation_Homo sapiens_hsa003100.39818651
156Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38144327
157Arginine biosynthesis_Homo sapiens_hsa002200.33814301
158Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33604267
159Viral carcinogenesis_Homo sapiens_hsa052030.32310771
160Renin secretion_Homo sapiens_hsa049240.31725721
161Choline metabolism in cancer_Homo sapiens_hsa052310.31380632
162Antigen processing and presentation_Homo sapiens_hsa046120.30000195
163Insulin signaling pathway_Homo sapiens_hsa049100.27594515
164Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25927018
165Primary immunodeficiency_Homo sapiens_hsa053400.23194029
166Gap junction_Homo sapiens_hsa045400.22693566
167Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21763147
168Fatty acid degradation_Homo sapiens_hsa000710.21083010
169N-Glycan biosynthesis_Homo sapiens_hsa005100.20537047
170B cell receptor signaling pathway_Homo sapiens_hsa046620.19691630
171MAPK signaling pathway_Homo sapiens_hsa040100.18891412
172Acute myeloid leukemia_Homo sapiens_hsa052210.15782840
173Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.14937272
174ErbB signaling pathway_Homo sapiens_hsa040120.13437625

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